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Aliases for MAPKAPK3 Gene

Aliases for MAPKAPK3 Gene

  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 2 3
  • 3PK 3 4 6
  • MAPK-Activated Protein Kinase 3 3 4
  • Chromosome 3p Kinase 3 4
  • MAPKAP Kinase 3 3 4
  • EC 2.7.11.1 4 63
  • MAPKAP-K3 3 4
  • MAPKAPK-3 3 4
  • MAPKAP3 3 6
  • MK-3 3 4
  • MAP Kinase-Activated Protein Kinase 3 3
  • EC 2.7.11 63

External Ids for MAPKAPK3 Gene

Previous GeneCards Identifiers for MAPKAPK3 Gene

  • GC03M049300
  • GC03M049470
  • GC03P050509
  • GC03P050613
  • GC03P050624

Summaries for MAPKAPK3 Gene

Entrez Gene Summary for MAPKAPK3 Gene

  • This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

GeneCards Summary for MAPKAPK3 Gene

MAPKAPK3 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase kinase activity. An important paralog of this gene is MKNK2.

UniProtKB/Swiss-Prot for MAPKAPK3 Gene

  • Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.

Gene Wiki entry for MAPKAPK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPKAPK3 Gene

Genomics for MAPKAPK3 Gene

Regulatory Elements for MAPKAPK3 Gene

Genomic Location for MAPKAPK3 Gene

Start:
50,611,520 bp from pter
End:
50,649,297 bp from pter
Size:
37,778 bases
Orientation:
Plus strand

Genomic View for MAPKAPK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPKAPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPKAPK3 Gene

Proteins for MAPKAPK3 Gene

  • Protein details for MAPKAPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16644-MAPK3_HUMAN
    Recommended name:
    MAP kinase-activated protein kinase 3
    Protein Accession:
    Q16644
    Secondary Accessions:
    • B5BU67

    Protein attributes for MAPKAPK3 Gene

    Size:
    382 amino acids
    Molecular mass:
    42987 Da
    Quaternary structure:
    • Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex: molecules are positioned face to face so that the ATP-binding sites of both kinases are at the heterodimer interface (By similarity). Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4.

    Three dimensional structures from OCA and Proteopedia for MAPKAPK3 Gene

neXtProt entry for MAPKAPK3 Gene

Proteomics data for MAPKAPK3 Gene at MOPED

Selected DME Specific Peptides for MAPKAPK3 Gene

Post-translational modifications for MAPKAPK3 Gene

  • Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1. Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-201, Ser-251 and Thr-313 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPKAPK3 Gene

Domains for MAPKAPK3 Gene

Suggested Antigen Peptide Sequences for MAPKAPK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q16644

UniProtKB/Swiss-Prot:

MAPK3_HUMAN :
  • Q16644
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAPKAPK3: view

Function for MAPKAPK3 Gene

Molecular function for MAPKAPK3 Gene

GENATLAS Biochemistry: mitogen-associated protein kinase-activated protein kinase,on a chromosome 3p segment,frequency deleted in small cell lung cancer
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited by ligand 5B (2-[2-(1,3-benzodioxol-5-yl)pyrimidin-4-yl]-5,6-dihydrospiro[piperidine-4,7-pyrrolo[3,2-c]pyridin]- 4(1h)-one) and ligand P4O (2-[2-(2-fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro- 4h-pyrrolo[3,2-c]pyridin-4-one), 2 ATP-competitive inhibitors
UniProtKB/Swiss-Prot Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.

Enzyme Numbers (IUBMB) for MAPKAPK3 Gene

Gene Ontology (GO) - Molecular Function for MAPKAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 15850461
GO:0004683 calmodulin-dependent protein kinase activity IBA --
GO:0004708 MAP kinase kinase activity TAS 10781029
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with MAPKAPK3: view
genes like me logo Genes that share phenotypes with MAPKAPK3: view

Animal Models for MAPKAPK3 Gene

MGI Knock Outs for MAPKAPK3:

miRNA for MAPKAPK3 Gene

miRTarBase miRNAs that target MAPKAPK3

No data available for Transcription Factor Targeting and HOMER Transcription for MAPKAPK3 Gene

Localization for MAPKAPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPKAPK3 Gene

Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPKAPK3 Gene COMPARTMENTS Subcellular localization image for MAPKAPK3 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAPKAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10781029
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MAPKAPK3: view

Pathways for MAPKAPK3 Gene

genes like me logo Genes that share pathways with MAPKAPK3: view

Pathways by source for MAPKAPK3 Gene

Gene Ontology (GO) - Biological Process for MAPKAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IBA --
GO:0000187 activation of MAPK activity TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MAPKAPK3: view

Compounds for MAPKAPK3 Gene

(2) HMDB Compounds for MAPKAPK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(3) Novoseek inferred chemical compound relationships for MAPKAPK3 Gene

Compound -log(P) Hits PubMed IDs
sb 203580 67.9 1
mannitol 40.9 1
serine 29.2 2
genes like me logo Genes that share compounds with MAPKAPK3: view

Transcripts for MAPKAPK3 Gene

Unigene Clusters for MAPKAPK3 Gene

Mitogen-activated protein kinase-activated protein kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - -
SP2:
SP3: -
SP4: - - -
SP5: -
SP6:
SP7: - - -

Relevant External Links for MAPKAPK3 Gene

GeneLoc Exon Structure for
MAPKAPK3
ECgene alternative splicing isoforms for
MAPKAPK3

Expression for MAPKAPK3 Gene

mRNA expression in normal human tissues for MAPKAPK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPKAPK3 Gene

This gene is overexpressed in Heart - Left Ventricle (9.3), Muscle - Skeletal (6.8), and Whole Blood (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPKAPK3 Gene

SOURCE GeneReport for Unigene cluster for MAPKAPK3 Gene Hs.234521

mRNA Expression by UniProt/SwissProt for MAPKAPK3 Gene

Q16644-MAPK3_HUMAN
Tissue specificity: Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain.
genes like me logo Genes that share expressions with MAPKAPK3: view

Orthologs for MAPKAPK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPKAPK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPKAPK3 35
  • 99.56 (n)
  • 99.48 (a)
MAPKAPK3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPKAPK3 35
  • 91.36 (n)
  • 95.81 (a)
MAPKAPK3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPKAPK3 35
  • 90.24 (n)
  • 95.5 (a)
MAPKAPK3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapkapk3 35
  • 88.13 (n)
  • 92.93 (a)
Mapkapk3 16
Mapkapk3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPKAPK3 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPKAPK3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapkapk3 35
  • 89.01 (n)
  • 93.46 (a)
chicken
(Gallus gallus)
Aves MAPKAPK3 35
  • 79.05 (n)
  • 90.57 (a)
MAPKAPK3 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPKAPK3 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19914 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mapkapk3 35
  • 73.81 (n)
  • 81.43 (a)
Str.11839 35
zebrafish
(Danio rerio)
Actinopterygii mapkapk3 35
  • 73.01 (n)
  • 79.55 (a)
mapkapk3 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011890 35
  • 65.08 (n)
  • 66.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta MAPk-Ak2 35
  • 67.46 (n)
  • 65.38 (a)
MAPk-Ak2 36
  • 61 (a)
OneToMany
MAPk-Ak2 37
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea mak-1 36
  • 32 (a)
ManyToMany
mak-2 35
  • 57.41 (n)
  • 59.4 (a)
mak-2 36
  • 54 (a)
ManyToMany
C44C8.6a 37
  • 59 (a)
C44C8.6b 37
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 36
  • 20 (a)
ManyToMany
RCK2 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for MAPKAPK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPKAPK3 Gene

ENSEMBL:
Gene Tree for MAPKAPK3 (if available)
TreeFam:
Gene Tree for MAPKAPK3 (if available)

Paralogs for MAPKAPK3 Gene

genes like me logo Genes that share paralogs with MAPKAPK3: view

Variants for MAPKAPK3 Gene

Sequence variations from dbSNP and Humsavar for MAPKAPK3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs371645 -- 50,636,955(-) ATAGG(A/C/G)ACAGG intron-variant
rs375544 -- 50,620,395(+) GTGAT(A/G)TACTC intron-variant
rs388195 -- 50,632,334(-) AAATT(A/T)TAATT intron-variant
rs396302 -- 50,637,037(-) CCACT(A/G)AGTCC intron-variant
rs399766 -- 50,622,381(-) gagaa(A/G)aaatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPKAPK3 Gene

Variant ID Type Subtype PubMed ID
nsv460533 CNV Loss 19166990
nsv508919 CNV Insertion 20534489
esv259700 OTHER Complex 20981092
esv990051 CNV Insertion 20482838
esv1531131 CNV Insertion 17803354
nsv3815 CNV Insertion 18451855

Relevant External Links for MAPKAPK3 Gene

HapMap Linkage Disequilibrium report
MAPKAPK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKAPK3 Gene

Disorders for MAPKAPK3 Gene

(3) Novoseek inferred disease relationships for MAPKAPK3 Gene

Disease -log(P) Hits PubMed IDs
shock 45.4 3
necrosis 19.3 1
tumors 0 1

Relevant External Links for MAPKAPK3

Genetic Association Database (GAD)
MAPKAPK3
Human Genome Epidemiology (HuGE) Navigator
MAPKAPK3
genes like me logo Genes that share disorders with MAPKAPK3: view

No data available for UniProtKB/Swiss-Prot for MAPKAPK3 Gene

Publications for MAPKAPK3 Gene

  1. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region. (PMID: 8622688) Sithanandam G. … Allikmets R. (Mol. Cell. Biol. 1996) 2 3 4 23
  2. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. (PMID: 8626550) McLaughlin M.M. … Young P.R. (J. Biol. Chem. 1996) 2 3 4 23
  3. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. (PMID: 8774846) Clifton A.D. … Cohen P. (FEBS Lett. 1996) 3 4 23
  4. Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. (PMID: 10781029) Neufeld B. … Rapp U.R. (J. Biol. Chem. 2000) 3 4 23
  5. A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C. (PMID: 19208361) Tsukada H. … Chayama K. (Gastroenterology 2009) 3 23 48

Products for MAPKAPK3 Gene

Sources for MAPKAPK3 Gene

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