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Aliases for MAPKAPK3 Gene

Aliases for MAPKAPK3 Gene

  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 2 3 5
  • MAPK-Activated Protein Kinase 3 3 4
  • Chromosome 3p Kinase 3 4
  • MAPKAP Kinase 3 3 4
  • EC 2.7.11.1 4 61
  • MAPKAP-K3 3 4
  • MAPKAPK-3 3 4
  • MK-3 3 4
  • 3PK 3 4
  • MAP Kinase-Activated Protein Kinase 3 3
  • EC 2.7.11 61
  • MAPKAP3 3
  • MDPT3 3

External Ids for MAPKAPK3 Gene

Previous GeneCards Identifiers for MAPKAPK3 Gene

  • GC03M049300
  • GC03M049470
  • GC03P050509
  • GC03P050613
  • GC03P050624

Summaries for MAPKAPK3 Gene

Entrez Gene Summary for MAPKAPK3 Gene

  • This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

GeneCards Summary for MAPKAPK3 Gene

MAPKAPK3 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3) is a Protein Coding gene. Diseases associated with MAPKAPK3 include Patterned Macular Dystrophy 3 and Interstitial Myocarditis. Among its related pathways are Type I Interferon Signaling Pathways and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPKAPK2.

UniProtKB/Swiss-Prot for MAPKAPK3 Gene

  • Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.

Gene Wiki entry for MAPKAPK3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPKAPK3 Gene

Genomics for MAPKAPK3 Gene

Regulatory Elements for MAPKAPK3 Gene

Enhancers for MAPKAPK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G050616 2 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +13.5 13480 18.0 HDGF PKNOX1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 DOCK3 HEMK1 MAPKAPK3 C3orf18 RAD54L2 MANF GNAI2 LSMEM2 HYAL1 RASSF1
GH03G050566 2.1 FANTOM5 Ensembl ENCODE dbSUPER 14.2 -39.6 -39617 10.0 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 CISH RAD54L2 SEMA3F-AS1 MAPKAPK3 TMEM115 HEMK1 DOCK3 NAT6 TRAIP RASSF1
GH03G050581 1.1 ENCODE dbSUPER 12.8 -27.4 -27366 5.8 HDGF ZSCAN4 RAD21 YY1 RELB IKZF2 CREM CEBPB JUNB TBX21 CISH MAPKAPK3 PIR34243 C3orf18
GH03G050598 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 5 -5.0 -5034 15.0 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 TMEM115 HEMK1 RAD54L2 C3orf18 SEMA3F-AS1 DOCK3 MANF GMPPB NAT6 TRAIP
GH03G050577 1 ENCODE dbSUPER 12.5 -34.0 -33981 0.9 CTCF ZSCAN4 ZNF766 SCRT2 NFE2 IKZF2 EGR2 ZBTB11 MNT DPF2 CISH MAPKAPK3 HEMK1 C3orf18 PIR34243
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAPKAPK3 on UCSC Golden Path with GeneCards custom track

Promoters for MAPKAPK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152388 280 1601 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 FOS

Genomic Location for MAPKAPK3 Gene

Chromosome:
3
Start:
50,611,520 bp from pter
End:
50,649,297 bp from pter
Size:
37,778 bases
Orientation:
Plus strand

Genomic View for MAPKAPK3 Gene

Genes around MAPKAPK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPKAPK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPKAPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPKAPK3 Gene

Proteins for MAPKAPK3 Gene

  • Protein details for MAPKAPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16644-MAPK3_HUMAN
    Recommended name:
    MAP kinase-activated protein kinase 3
    Protein Accession:
    Q16644
    Secondary Accessions:
    • B5BU67

    Protein attributes for MAPKAPK3 Gene

    Size:
    382 amino acids
    Molecular mass:
    42987 Da
    Quaternary structure:
    • Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex: molecules are positioned face to face so that the ATP-binding sites of both kinases are at the heterodimer interface (By similarity). Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4.

    Three dimensional structures from OCA and Proteopedia for MAPKAPK3 Gene

neXtProt entry for MAPKAPK3 Gene

Selected DME Specific Peptides for MAPKAPK3 Gene

Q16644:
  • AISPGMK
  • NIAHRDVKPENLLYTSK
  • YVAPEVL
  • AFTEREA
  • TDFGFAK
  • PEWSEVSE
  • TPYYVAP

Post-translational modifications for MAPKAPK3 Gene

  • Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1. Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-201, Ser-251 and Thr-313 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPKAPK3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPKAPK3 (MAPKAPK3)
  • Cloud-Clone Corp. Antibodies for MAPKAPK3

Protein Products

  • Cloud-Clone Corp. Proteins for MAPKAPK3

Domains & Families for MAPKAPK3 Gene

Suggested Antigen Peptide Sequences for MAPKAPK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q16644

UniProtKB/Swiss-Prot:

MAPK3_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAPKAPK3: view

Function for MAPKAPK3 Gene

Molecular function for MAPKAPK3 Gene

GENATLAS Biochemistry:
mitogen-associated protein kinase-activated protein kinase,on a chromosome 3p segment,frequency deleted in small cell lung cancer
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited by ligand 5B (2-[2-(1,3-benzodioxol-5-yl)pyrimidin-4-yl]-5,6-dihydrospiro[piperidine-4,7-pyrrolo[3,2-c]pyridin]- 4(1h)-one) and ligand P4O (2-[2-(2-fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro- 4h-pyrrolo[3,2-c]pyridin-4-one), 2 ATP-competitive inhibitors.
UniProtKB/Swiss-Prot Function:
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.

Enzyme Numbers (IUBMB) for MAPKAPK3 Gene

Gene Ontology (GO) - Molecular Function for MAPKAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity EXP,IDA 8774846
GO:0004683 calmodulin-dependent protein kinase activity IBA --
GO:0004708 MAP kinase kinase activity TAS 10781029
genes like me logo Genes that share ontologies with MAPKAPK3: view
genes like me logo Genes that share phenotypes with MAPKAPK3: view

Animal Models for MAPKAPK3 Gene

MGI Knock Outs for MAPKAPK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPKAPK3

CRISPR Products

miRNA for MAPKAPK3 Gene

miRTarBase miRNAs that target MAPKAPK3

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPKAPK3 Gene

Localization for MAPKAPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPKAPK3 Gene

Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPKAPK3 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAPKAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10781029
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPKAPK3: view

Pathways & Interactions for MAPKAPK3 Gene

genes like me logo Genes that share pathways with MAPKAPK3: view

SIGNOR curated interactions for MAPKAPK3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAPKAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0002224 toll-like receptor signaling pathway ISS --
GO:0006468 protein phosphorylation IEA --
GO:0006950 response to stress TAS 8626550
genes like me logo Genes that share ontologies with MAPKAPK3: view

Drugs & Compounds for MAPKAPK3 Gene

(6) Drugs for MAPKAPK3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE Experimental Pharma Target 0
2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE Experimental Pharma Target 0

(1) Additional Compounds for MAPKAPK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAPKAPK3: view

Transcripts for MAPKAPK3 Gene

Unigene Clusters for MAPKAPK3 Gene

Mitogen-activated protein kinase-activated protein kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - -
SP2:
SP3: -
SP4: - - -
SP5: -
SP6:
SP7: - - -

Relevant External Links for MAPKAPK3 Gene

GeneLoc Exon Structure for
MAPKAPK3
ECgene alternative splicing isoforms for
MAPKAPK3

Expression for MAPKAPK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPKAPK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPKAPK3 Gene

This gene is overexpressed in Heart - Left Ventricle (x9.3), Muscle - Skeletal (x6.8), and Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for MAPKAPK3 Gene

This gene is overexpressed in Heart (33.3) and Peripheral blood mononuclear cells (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPKAPK3 Gene



NURSA nuclear receptor signaling pathways regulating expression of MAPKAPK3 Gene:

MAPKAPK3

SOURCE GeneReport for Unigene cluster for MAPKAPK3 Gene:

Hs.234521

mRNA Expression by UniProt/SwissProt for MAPKAPK3 Gene:

Q16644-MAPK3_HUMAN
Tissue specificity: Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. Expressed in the retinal pigment epithelium (PubMed:26744326).

Evidence on tissue expression from TISSUES for MAPKAPK3 Gene

  • Heart(4.5)
  • Intestine(4.3)
  • Skin(4.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with MAPKAPK3: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPKAPK3 Gene

Orthologs for MAPKAPK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPKAPK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPKAPK3 34 35
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia MAPKAPK3 35 34
  • 91.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAPKAPK3 35 34
  • 90.24 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapkapk3 34
  • 89.01 (n)
mouse
(Mus musculus)
Mammalia Mapkapk3 16 35 34
  • 88.13 (n)
oppossum
(Monodelphis domestica)
Mammalia MAPKAPK3 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPKAPK3 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPKAPK3 34 35
  • 79.05 (n)
lizard
(Anolis carolinensis)
Reptilia MAPKAPK3 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapkapk3 34
  • 73.81 (n)
Str.11839 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19914 34
zebrafish
(Danio rerio)
Actinopterygii mapkapk3 34 35
  • 73.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta MAPk-Ak2 36 34 35
  • 67.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011890 34
  • 65.08 (n)
worm
(Caenorhabditis elegans)
Secernentea C44C8.6a 36
  • 59 (a)
C44C8.6b 36
  • 59 (a)
mak-2 34 35
  • 57.41 (n)
mak-1 35
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 35
  • 20 (a)
ManyToMany
RCK2 35
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToMany
Species where no ortholog for MAPKAPK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPKAPK3 Gene

ENSEMBL:
Gene Tree for MAPKAPK3 (if available)
TreeFam:
Gene Tree for MAPKAPK3 (if available)

Paralogs for MAPKAPK3 Gene

Variants for MAPKAPK3 Gene

Sequence variations from dbSNP and Humsavar for MAPKAPK3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_040755 A glioblastoma multiforme sample
VAR_077085 Macular dystrophy, patterned, 3 (MDPT3) [MIM:617111]
rs886037913 Pathogenic 50,644,422(+) CCTAC(C/T)CTACA intron-variant, reference, missense
rs414171 other 50,612,068(-) ACCGC(A/T)CGGCT upstream-variant-2KB, utr-variant-5-prime
rs1000030132 -- 50,618,742(+) TGGAG(G/T)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPKAPK3 Gene

Variant ID Type Subtype PubMed ID
esv1531131 CNV insertion 17803354
esv3302726 CNV tandem duplication 20981092
esv3584502 CNV gain 24956385
esv990051 CNV insertion 20482838
nsv3815 CNV insertion 18451855
nsv460533 CNV loss 19166990
nsv508919 CNV insertion 20534489
nsv590273 CNV loss 21841781

Variation tolerance for MAPKAPK3 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPKAPK3 Gene

Human Gene Mutation Database (HGMD)
MAPKAPK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPKAPK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKAPK3 Gene

Disorders for MAPKAPK3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for MAPKAPK3 Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
patterned macular dystrophy 3
  • martinique crinkled retinal pigment epitheliopathy
interstitial myocarditis
immature cataract
  • incipient cataract
endemic typhus
  • cat flea rickettsiosis
patterned macular dystrophy
  • patterned dystrophy of retinal pigment epithelium
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MAPK3_HUMAN
  • Macular dystrophy, patterned, 3 (MDPT3) [MIM:617111]: A form of retinal patterned dystrophy, characterized by retinal pigment epithelium and Bruchs membrane changes resembling a dry desert land. It begins around the age of 30 and progresses to retinitis pigmentosa. MDPT3 inheritance is autosomal dominant. {ECO:0000269 PubMed:26744326}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MAPKAPK3

Genetic Association Database (GAD)
MAPKAPK3
Human Genome Epidemiology (HuGE) Navigator
MAPKAPK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPKAPK3
genes like me logo Genes that share disorders with MAPKAPK3: view

No data available for Genatlas for MAPKAPK3 Gene

Publications for MAPKAPK3 Gene

  1. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region. (PMID: 8622688) Sithanandam G. … Allikmets R. (Mol. Cell. Biol. 1996) 2 3 4 22 64
  2. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. (PMID: 8626550) McLaughlin M.M. … Young P.R. (J. Biol. Chem. 1996) 2 3 4 22 64
  3. A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C. (PMID: 19208361) Tsukada H. … Chayama K. (Gastroenterology 2009) 3 22 46 64
  4. Mitogen-activated 3p kinase is active in the nucleus. (PMID: 15302577) Zakowski V. … Ludwig S. (Exp. Cell Res. 2004) 3 4 22 64
  5. Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. (PMID: 10781029) Neufeld B. … Rapp U.R. (J. Biol. Chem. 2000) 3 4 22 64

Products for MAPKAPK3 Gene

Sources for MAPKAPK3 Gene

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