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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPKAPK3 Gene

protein-coding   GIFtS: 65
GCID: GC03P050648

mitogen-activated protein kinase-activated protein kinase...
 Explore 10 diseases affiliated with
MAPKAPK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAPKAPK3    

Aliases
for MAPKAPK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase-Activated Protein Kinase 31 2     MK-32 3
3PK1 2 5     MAPK-Activated Protein Kinase 32 3
MAPKAP31 2 5     MAPKAP Kinase 32 3
3pK1 3     EC 2.7.11.13 8
Chromosome 3p Kinase2 3     MAP Kinase-Activated Protein Kinase 32
MAPKAP-K32 3     EC 2.7.118
MAPKAPK-32 3     

External Ids:    HGNC: 68881   Entrez Gene: 78672   Ensembl: ENSG000001147387   OMIM: 6021305   UniProtKB: Q166443   

Export aliases for MAPKAPK3 gene to outside databases

Previous GC identifers: GC03M049300 GC03M049470 GC03P050509 GC03P050613 GC03P050624


Summaries
for MAPKAPK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPKAPK3:
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein
kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases
(ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth
inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal
kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an
integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with,
phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be
involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in
multiple transcript variants that encode the same protein. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644
Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell
migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated
by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide
sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and
substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2.
Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1
in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and
impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in
inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by
phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and
translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF,
promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent
degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells:
required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of
Polycomb-mediated repression

Gene Wiki entry for MAPKAPK3


Genomic Views
for MAPKAPK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPKAPK3 gene promoter:
         STAT5B   GR   NRSF form 1   GR-beta   STAT5A   NRSF form 2   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAPKAPK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPKAPK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPKAPK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.3

MAPKAPK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPKAPK3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050648:  view genomic region     (about GC identifiers)

Start:
 50,648,951 bp from pter      End:
 50,686,720 bp from pter
Size:
 37,770 bases      Orientation:
 plus strand

Proteins
for MAPKAPK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644 (See protein sequence)
Recommended Name: MAP kinase-activated protein kinase 3  
Size: 382 amino acids; 42987 Da
Subunit: Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex: molecules are
positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer interface (By
similarity). Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to
the cytoplasm
4 PDB 3D structures from and Proteopedia for MAPKAPK3:
3FHR (3D)        3FXW (3D)        3R1N (3D)        3SHE (3D)    
Secondary accessions: B5BU67

Explore the universe of human proteins at neXtProt for MAPKAPK3: NX_Q16644

Post-translational modifications:

  • Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1. Phosphorylated and activated by MAP kinase p38-alpha/MAPK14
    • at Thr-201, Ser-251 and Thr-313 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16644

    • 4/7 DME Specific Peptides for MAPKAPK3 (Q16644) (see all 7)
     TPYYVAP  AISPGMK  AFTEREA  TDFGFAK 

    MAPKAPK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230854.1  NP_001230855.1  NP_004626.1  

    ENSEMBL proteins: 
     ENSP00000396467   ENSP00000410970   ENSP00000350639   ENSP00000402045   ENSP00000394894  
    Reactome Protein details: Q16644
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAPKAPK3 Protein
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    Enzo Life Sciences proteins for MAPKAPK3
    OriGene Purified Protein: MAPKAPK3
    OriGene Protein Over-expression Lysate: MAPKAPK3
    OriGene Custom Protein Services for MAPKAPK3 
    GenScript Custom Purified and Recombinant Proteins Services for MAPKAPK3
    Novus Biologicals MAPKAPK3 Proteins
    Novus Biologicals MAPKAPK3 Lysate
    Sino Biological Recombinant Protein for MAPKAPK3
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAPKAPK3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10781029
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--


    MAPKAPK3 for ontologies           About GeneDecksing



    MAPKAPK3 Antibody Products: 
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    Novus Biologicals MAPKAPK3 Antibodies
    Search for Antibodies for MAPKAPK3 at Abcam  
    Uscn Antibodies for MAPKAPK3
    ThermoFisher Antibodies for MAPKAPK3

    Assay Products for MAPKAPK3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript MAPKAPK3-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAPKAPK3

    Protein Domains /
    Families
    for MAPKAPK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPKAPK3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q16644

    ProtoNet protein and cluster: Q16644

    UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Function
    for MAPKAPK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644
    Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell
    migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated
    by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide
    sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and
    substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2.
    Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1
    in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and
    impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in
    inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by
    phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and
    translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF,
    promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent
    degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells:
    required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of
    Polycomb-mediated repression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited by
    ligand 5B (2'-[2-(1,3-benzodioxol-5-yl)pyrimidin-4-yl]-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]-
    4'(1'h)-one) and ligand P4O (2-[2-(2-fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro- 4h-pyrrolo[3,2-c]pyridin-4-one), 2
    ATP-competitive inhibitors

         Genatlas biochemistry entry for MAPKAPK3:
    mitogen-associated protein kinase-activated protein kinase,on a chromosome 3p segment,frequency deleted in small cell
    lung cancer

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MAPKAPK3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPKAPK3
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPKAPK3 (see all 12):
    hsa-miR-3140-3p hsa-miR-3065-3p hsa-miR-27a hsa-miR-128 hsa-miR-3065-5p hsa-miR-3681* hsa-miR-4299 hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmid: MAPKAPK3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPKAPK3 (see all 7)
    OriGene shRNA RFP: MAPKAPK3
    OriGene siRNA: MAPKAPK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPKAPK3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPKAPK3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK3 (see all 3)
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    Sino Biological Human cDNA Clone for MAPKAPK3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAPK3 

    Cell Line
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    Search LifeMap BioReagents cell lines for MAPKAPK3

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAPK3

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IDA15850461
    GO:0004708MAP kinase kinase activity TAS10781029
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----


    MAPKAPK3 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for MAPKAPK3:
     Decreased focal adhesion (FA)   Decreased nuclei size in G2M  Decreased substrate adherent c  Increased colony dispersion (i 

    Animal Models:
         Mouse knock-out Mapkapk3tm1.1Lex for MAPKAPK3
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mapkapk3):
     embryogenesis  immune system  mortality/aging  no phenotypic analysis 

    MAPKAPK3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPKAPK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2Signalling to RAS
    		Signalling to RAS1.00
    		p38MAPK events0.48
    		Signalling to ERKs0.73
    3Immune System
    		Immune System1.00
    		Innate Immune System0.46
    4Signaling by FGFR
    		NGF signalling via TRKA from the plasma membrane0.70
    		Signalling by NGF0.52
    5MAP Kinase Signaling
    		MAP Kinase Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPKAPK3
        VEGF Pathway
    p38 Signaling
    Signaling Involved in Cardiac Hypertrophy
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPKAPK3
        MAP Kinase Signaling

    3 BioSystems Pathways for MAPKAPK3 
        FAS pathway and Stress induction of HSP regulation
    Signaling mediated by p38-alpha and p38-beta
    p38 signaling mediated by MAPKAP kinases

    5/28        Reactome Pathways for MAPKAPK3 (see all 28)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 7/8 (TLR7/8) Cascade


    2         Kegg Pathways  (Kegg details for MAPKAPK3):
        MAPK signaling pathway
    VEGF signaling pathway


    MAPKAPK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPKAPK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/23 Interacting proteins for MAPKAPK3 (Q166441, 2, 3 ENSP000003506394) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZH2Q159102, 3, ENSP000003201474MINT-8262742 I2D: score=2 STRING: ENSP00000320147
    HSPB1P047921, 3, ENSP000002485534EBI-1384657,EBI-352682 I2D: score=2 STRING: ENSP00000248553
    COPS6Q7L5N12, 3MINT-8262731 I2D: score=2 
    SMSP527882, 3MINT-8262775 I2D: score=2 
    SUMO3P558542, 3MINT-8262786 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006950response to stress IDA8774846


    MAPKAPK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPKAPK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPKAPK3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for MAPKAPK3

    Browse Tocris compounds for MAPKAPK3

    2 HMDB Compounds for MAPKAPK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for MAPKAPK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE-- --target--10592235
    2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE-- --target--10592235

    3 Novoseek chemical compound relationships for MAPKAPK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 67.9 2 8626550 (1)
    mannitol 40.9 2 8626550 (1)
    serine 29.2 2 8774846 (1), 10383393 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPKAPK3 / MAPK3 

    Transcripts
    for MAPKAPK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPKAPK3 gene (3 alternative transcripts): 
    NM_001243925.1  NM_001243926.1  NM_004635.4  

    Unigene Cluster for MAPKAPK3:

    Mitogen-activated protein kinase-activated protein kinase 3
    Hs.234521  [show with all ESTs]
    Unigene Representative Sequence: NM_001243926
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486712 ENST00000446044(uc003day.2 uc010hlr.2) ENST00000497283
    ENST00000430409 ENST00000357955(uc003daz.2 uc003dba.2) ENST00000457064
    ENST00000451680

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPKAPK3 (see all 12):
    hsa-miR-3140-3p hsa-miR-3065-3p hsa-miR-27a hsa-miR-128 hsa-miR-3065-5p hsa-miR-3681* hsa-miR-4299 hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmid: MAPKAPK3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPKAPK3 (see all 7)
    OriGene shRNA RFP: MAPKAPK3
    OriGene siRNA: MAPKAPK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPKAPK3
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAPKAPK3 (NM_004635)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPKAPK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAPK3 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPKAPK3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPKAPK3

    Additional cDNA sequence: 

    AB451303.1 AB451434.1 AK290969.1 AK313565.1 BC001662.2 BC007591.1 BC010407.2 BC068497.1 
    U09578.1 U43784.1 

    7 DOTS entries:

    DT.97785686  DT.416016  DT.101970480  DT.100784697  DT.100784698  DT.100784695  DT.95369019 

    24/331 AceView cDNA sequences (see all 331):

    BI031167 BU527991 BU854733 AW615650 BF933053 BG742083 BU167764 BE274382 
    CR606251 BM904934 BM848086 NM_004635 BM792490 BE745755 BU146286 CB158502 
    BU146508 BM694280 BU844643 U43784 CA307066 CF132384 AA356809 BU148701 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
    SP1:                                                                                                        -     -                     
    SP2:                                                                                                                                    
    SP3:                                                              -                                                                     
    SP4:        -     -     -                                                                                                               
    SP5:                    -                                                                                                               


    ECgene alternative splicing isoforms for MAPKAPK3

    Expression
    for MAPKAPK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPKAPK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGATAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPKAPK3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAPKAPK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPKAPK3

    SOURCE GeneReport for Unigene cluster: Hs.234521

    UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644
    Tissue specificity: Widely expressed, with a higher expression level observed in heart and skeletal muscle. No
    expression in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPKAPK3: 
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for MAPKAPK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAPKAPK3 gene from 6/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAPKAPK31 mitogen-activated protein kinase-activated protein more 76.09(n)
    85.08(a)    		   415917  XM_414262.3  XP_414262.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPKAPK36
    		 --
    		 91(a)
    		 1 ↔ 1
    		 2(151606103-151723509)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.199142 Xenopus laevis transcribed sequence with moderate similarity more 79.57(n)    CD328653.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mapkapk31 mitogen-activated protein kinase-activated protein more 71.35(n)
    77.03(a)    		   790934  NM_001080079.1  NP_001073548.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MAPk-Ak21 , 3 protein amino acid phosphorylation protein
    kinase3
    MAP kinase activated protein-kinase-21    		 65(a)3
    67.46(n)1
    65.38(a)1    		   1 5C13
    445731  NM_001201618.11  NP_001188547.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea C44C8.6b3
    mak-21    		 Protein MAK-21 59(a)
    (best of 2)3
    57.73(n)1
    59.64(a)1    		   IV(884915-889900)3
    1769141  NM_067604.41  NP_500005.11 


    ENSEMBL Gene Tree for MAPKAPK3 (if available)
    TreeFam Gene Tree for MAPKAPK3 (if available) 

    Paralogs
    for MAPKAPK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPKAPK3 gene
    MAPKAPK52  MAPKAPK22  MKNK12  MKNK22  
    18/49 SIMAP similar genes for MAPKAPK3 using alignment to 5 protein entries:     MAPK3_HUMAN (see all proteins) (see all similar genes):
    MAPKAPK2    MARK4    MAPKAPK5    STK33    PNCK    RPS6KA1
    RPS6KA6    CAMK1    CAMKV    CAMK1D    DCLK3    RPS6KA2
    TRIB2    CAMK1G    CASK    NUAK1    RPS6KA5    STK17A

    MAPKAPK3 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPKAPK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/501 NCBI SNPs in MAPKAPK3 are shown (see all 501)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1450757481,2
    		--50651284(+) AGTAAC/TGGTTT 1 -- ut510--------
    rs7437531,2
    		C,F,A,H,--50651395(+) GCCCCC/TAGGCC 1 -- ut51 ese319Minor allele frequency- T:0.24NA EA NS WA 3784
    rs757017661,2
    		F,--50651396(+) CCCCCA/GGGCCT 1 -- ut511Minor allele frequency- G:0.04WA 118
    rs1509549731,2
    		--50651400(+) CAGGCC/TTGTCC 1 -- ut510--------
    rs1407937211,2
    		--50651455(+) GTCAGG/TGATTA 1 -- int10--------
    rs1504494251,2
    		--50651464(+) TATGCA/GGTCTA 1 -- int10--------
    rs1453630221,2
    		--50651615(+) CTCTGA/GCCAAC 1 -- int10--------
    rs1492086481,2
    		--50651665(+) CCCTGG/TCTCTG 1 -- int10--------
    rs1451682811,2
    		--50651707(+) CCCCCA/TCTCAT 1 -- int10--------
    rs8739851,2
    		C,F,H,--50651751(+) CTTCTA/GGGATA 1 -- int120Minor allele frequency- G:0.06NS EA NA 2414

    HapMap Linkage Disequilibrium report for MAPKAPK3 (50648951 - 50686720 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAPKAPK3: --

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    Disorders / Diseases
    for MAPKAPK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPKAPK3 for disorders           About GeneDecksing

    OMIM gene information: 602130    OMIM disorders: --

    10 diseases for MAPKAPK3:    About MalaCards
    saethre-chotzen syndrome    hepatitis c    melanoma    lung cancer
    ischemia    hepatitis    schizophrenia    pancreatitis
    malaria    alcoholism

    3 Novoseek disease relationships for MAPKAPK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 45.4 3 9048659 (1), 12826286 (1), 9393975 (1)
    necrosis 19.3 1 8774846 (1)
    tumors 0 2 16367997 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAPKAPK3 (5 documents)

    Export disorders for MAPKAPK3 gene to outside databases

    Publications
    for MAPKAPK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPKAPK3 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with MAPKAPK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. (PubMed id 8626550)1, 2, 3, 9 McLaughlin M.M.... Young P.R. (1996)
    2. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region. (PubMed id 8622688)1, 2, 3, 9 Sithanandam G....Shrestha S. (1996)
    3. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. (PubMed id 8774846)1, 2, 9 Clifton A.D....Cohen P. (1996)
    4. Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. (PubMed id 10781029)1, 2, 9 Neufeld B.... Rapp U.R. (2000)
    5. Mitogen-activated 3p kinase is active in the nucleus. (PubMed id 15302577)1, 2, 9 Zakowski V.... Ludwig S. (2004)
    6. High-resolution crystal structure of human Mapkap kin ase 3 in complex with a high affinity ligand. (PubMed id 19937655)1, 2 Cheng R....Hesterkamp T. (2010)
    7. MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. (PubMed id 15563468)1, 2 Voncken J.W.... Rapp U.R. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. 3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways. (PubMed id 8943323)1, 9 Ludwig S....Rapp U.R. (1996)
    10. A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C. (PubMed id 19208361)1, 9 Tsukada H....Chayama K. (2009)

    External Searches for MAPKAPK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAPKAPK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7867 HGNC: 6888 AceView: MAPKAPK3 Ensembl:ENSG00000114738 euGenes: HUgn7867
    ECgene: MAPKAPK3 Kegg: 7867 H-InvDB: MAPKAPK3

    Other Databases showing MAPKAPK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAPKAPK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPKAPK3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAPKAPK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPKAPK3 gene:
    Search GeneIP for patents involving MAPKAPK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MAPKAPK3 gene

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