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MAPKAPK3 Gene

protein-coding   GIFtS: 70
GCID: GC03P050648

Mitogen-Activated Protein Kinase-Activated Protein Kinase...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase-Activated Protein Kinase 31 2     EC 2.7.11.13 8
Chromosome 3p Kinase2 3     3PK2 5
MAPKAP-K32 3     MAPKAP32 5
MAPKAPK-32 3     MAP Kinase-Activated Protein Kinase 32
MK-32 3     3pK3
MAPK-Activated Protein Kinase 32 3     EC 2.7.118
MAPKAP Kinase 32 3     

External Ids:    HGNC: 68881   Entrez Gene: 78672   Ensembl: ENSG000001147387   OMIM: 6021305   UniProtKB: Q166443   

Export aliases for MAPKAPK3 gene to outside databases

Previous GC identifers: GC03M049300 GC03M049470 GC03P050509 GC03P050613 GC03P050624


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPKAPK3 Gene:
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated
protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular
signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was
shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK,
p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested
the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase
was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix
transcription factor known to be involved in the regulation of tissue-specific gene expression and cell
differentiation. Alternate splicing results in multiple transcript variants that encode the same protein.
(provided by RefSeq, Sep 2011)

GeneCards Summary for MAPKAPK3 Gene:
MAPKAPK3 (mitogen-activated protein kinase-activated protein kinase 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase kinase activity. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644
Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell
migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and
activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the
peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same
function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower
compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates
phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small
heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against
oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6
production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as
TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36,
a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA
affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like
receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by
phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression

Gene Wiki entry for MAPKAPK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPKAPK3 gene promoter:
         STAT5B   GR   NRSF form 1   GR-beta   STAT5A   NRSF form 2   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPKAPK3 promoter sequence
   Search Chromatin IP Primers for MAPKAPK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPKAPK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.3

MAPKAPK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPKAPK3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050648:  view genomic region     (about GC identifiers)

Start:
50,648,951 bp from pter      End:
50,686,720 bp from pter
Size:
37,770 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644 (See protein sequence)
Recommended Name: MAP kinase-activated protein kinase 3  
Size: 382 amino acids; 42987 Da
Subunit: Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex:
molecules are positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer
interface (By similarity). Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4
4 PDB 3D structures from and Proteopedia for MAPKAPK3:
3FHR (3D)        3FXW (3D)        3R1N (3D)        3SHE (3D)    
Secondary accessions: B5BU67

Explore the universe of human proteins at neXtProt for MAPKAPK3: NX_Q16644

Explore proteomics data for MAPKAPK3 at MOPED

Post-translational modifications: 

  • Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1. Phosphorylated and activated by MAP kinase
    p38-alpha/MAPK14 at Thr-201, Ser-251 and Thr-313 (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPKAPK3 (Q16644) (see all 7)
     TPYYVAP  AISPGMK  AFTEREA  TDFGFAK 


    See MAPKAPK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230854.1  NP_001230855.1  NP_004626.1  

    ENSEMBL proteins: 
     ENSP00000396467   ENSP00000410970   ENSP00000350639   ENSP00000402045   ENSP00000394894  
    Reactome Protein details: Q16644

    MAPKAPK3 Human Recombinant Protein Products:

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    Novus Biologicals MAPKAPK3 Proteins
    Novus Biologicals MAPKAPK3 Lysate
    Sino Biological Recombinant Protein for MAPKAPK3
    Sino Biological Cell Lysate for MAPKAPK3
    ProSpec Recombinant Protein for MAPKAPK3
    Cloud-Clone Corp. Proteins for MAPKAPK3

     
    Search eBioscience for Proteins for MAPKAPK3 

     
    antibodies-online proteins for MAPKAPK3 (6 products) 

     
    antibodies-online peptides for MAPKAPK3

    MAPKAPK3 Antibody Products:

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    antibodies-online antibodies for MAPKAPK3 (35 products) 

    MAPKAPK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPKAPK3
    Cloud-Clone Corp. CLIAs for MAPKAPK3
    Search eBioscience for ELISAs for MAPKAPK3 
    antibodies-online kits for MAPKAPK3 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase-activated protein kinase 3
    MAPKAPK subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q16644

    ProtoNet protein and cluster: Q16644

    UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAPKAPK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAPK3_HUMAN, Q16644
    Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell
    migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and
    activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the
    peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same
    function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower
    compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates
    phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small
    heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against
    oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6
    production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as
    TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36,
    a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA
    affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like
    receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by
    phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited
    by ligand 5B
    (2'-[2-(1,3-benzodioxol-5-yl)pyrimidin-4-yl]-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]-
    4'(1'h)-one) and ligand P4O (2-[2-(2-fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro-
    4h-pyrrolo[3,2-c]pyridin-4-one), 2 ATP-competitive inhibitors

         Genatlas biochemistry entry for MAPKAPK3:
    mitogen-associated protein kinase-activated protein kinase,on a chromosome 3p segment,frequency deleted in small
    cell lung cancer

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15850461
    GO:0004708MAP kinase kinase activity TAS10781029
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with MAPKAPK3           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for MAPKAPK3:
     Decreased focal adhesion (FA)   Decreased nuclei size in G2M  Decreased substrate adherent c  Increased colony dispersion (i 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mapkapk3):
     embryogenesis  immune system  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with MAPKAPK3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mapkapk3tm1.1Lex for MAPKAPK3

       genOway: Develop your customized and physiologically relevant rodent model for MAPKAPK3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPKAPK3:
    hsa-mir-124-3p (MIRT022623)

    Block miRNA regulation of human, mouse, rat MAPKAPK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPKAPK3 (see all 12):
    hsa-miR-3140-3p hsa-miR-3065-3p hsa-miR-27a hsa-miR-128 hsa-miR-3065-5p hsa-miR-3681* hsa-miR-4299 hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmidMAPKAPK3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPKAPK3
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    Addgene plasmids for MAPKAPK3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAPK3_HUMAN, Q16644: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it
    translocates to the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10781029
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0016020membrane ----

    Find genes that share ontologies with MAPKAPK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPKAPK3 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    MAP kinase activation in TLR cascade0.61
    activated TAK1 mediates p38 MAPK activation0.00
    MAP Kinase Signaling0.31
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    4Signalling to ERKs
    Signalling to ERKs0.73
    p38MAPK events0.00
    Signalling to RAS0.73
    5Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71


    Find genes that share SuperPaths with MAPKAPK3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPKAPK3
        VEGF Pathway
    p38 Signaling
    Signaling Involved in Cardiac Hypertrophy
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPKAPK3
        MAP Kinase Signaling

    3 BioSystems Pathways for MAPKAPK3
        FAS pathway and Stress induction of HSP regulation
    Signaling mediated by p38-alpha and p38-beta
    p38 signaling mediated by MAPKAP kinases

    1 Sino Biological Pathway for MAPKAPK3
        VEGF Signaling

    3 Reactome Pathways for MAPKAPK3
        Oxidative Stress Induced Senescence
    activated TAK1 mediates p38 MAPK activation
    p38MAPK events


    2 Kegg Pathways  (Kegg details for MAPKAPK3):
        MAPK signaling pathway
    VEGF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPKAPK3: 
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPKAPK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPKAPK3 (Q166441, 2, 3 ENSP000003506394) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZH2Q159102, 3, ENSP000003201474MINT-8262742 I2D: score=2 STRING: ENSP00000320147
    HSPB1P047921, 3, ENSP000002485534EBI-1384657,EBI-352682 I2D: score=2 STRING: ENSP00000248553
    COPS6Q7L5N12, 3MINT-8262731 I2D: score=2 
    SMSP527882, 3MINT-8262775 I2D: score=2 
    SUMO3P558542, 3MINT-8262786 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with MAPKAPK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MAPKAPK3
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPKAPK3 (MAPK3)

    2 HMDB Compounds for MAPKAPK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for MAPKAPK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE-- --target--10592235
    2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE-- --target--10592235

    3 Novoseek inferred chemical compound relationships for MAPKAPK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 67.9 2 8626550 (1)
    mannitol 40.9 2 8626550 (1)
    serine 29.2 2 8774846 (1), 10383393 (1)



    Find genes that share compounds with MAPKAPK3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAPKAPK3 gene (3 alternative transcripts): 
    NM_001243925.1  NM_001243926.1  NM_004635.4  

    Unigene Cluster for MAPKAPK3:

    Mitogen-activated protein kinase-activated protein kinase 3
    Hs.234521  [show with all ESTs]
    Unigene Representative Sequence: NM_001243926
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486712 ENST00000446044(uc003day.2 uc010hlr.2) ENST00000497283
    ENST00000430409 ENST00000357955(uc003daz.2 uc003dba.2) ENST00000457064
    ENST00000451680
    miRNA
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    Additional mRNA sequence: 

    AB451303.1 AB451434.1 AK290969.1 AK313565.1 BC001662.2 BC007591.1 BC010407.2 BC068497.1 
    U09578.1 U43784.1 

    7 DOTS entries:

    DT.97785686  DT.416016  DT.101970480  DT.100784697  DT.100784698  DT.100784695  DT.95369019 

    Selected AceView cDNA sequences (see all 331):

    BI031167 BU183682 AW615650 CB158502 BU146286 BU527991 BU844643 BU854733 
    BM792490 BQ719796 BU146508 BM848086 U43784 CF132384 BM694280 BE745755 
    BE274382 NM_004635 BM904934 BQ933501 BM763538 BU148701 AA356809 BM908923 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
    SP1:                                                                                                        -     -                     
    SP2:                                                                                                                                    
    SP3:                                                              -                                                                     
    SP4:        -     -     -                                                                                                               
    SP5:                    -                                                                                                               


    ECgene alternative splicing isoforms for MAPKAPK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPKAPK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGATAGGA
    MAPKAPK3 Expression
    About this image


    MAPKAPK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Heart (Cardiovascular System)
     
     Thyroid (Endocrine System)
    MAPKAPK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPKAPK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.234521

    UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644
    Tissue specificity: Widely expressed, with a higher expression level observed in heart and skeletal muscle. No
    expression in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPKAPK3: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAPKAPK3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapkapk31 , 5 mitogen-activated protein kinase-activated protein more1, 5 88.13(n)1
    92.93(a)1
      9 (57.98 cM)5
    1026261  NM_178907.31  NP_849238.11 
     1072549275 
    chicken
    (Gallus gallus)
    Aves MAPKAPK31 mitogen-activated protein kinase-activated protein more 79.05(n)
    90.57(a)
      415917  XM_414262.4  XP_414262.3 
    lizard
    (Anolis carolinensis)
    Reptilia MAPKAPK36
    mitogen-activated protein kinase-activated protein...
    84(a)
    1 ↔ 1
    2(151606274-151726809)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.199142 Xenopus laevis transcribed sequence with moderate similarity more 79.57(n)    CD328653.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapkapk31 mitogen-activated protein kinase-activated protein more 73.01(n)
    79.55(a)
      790934  NM_001080079.1  NP_001073548.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MAPk-Ak21 , 3 protein amino acid phosphorylation
    protein kinase3
    MAP kinase activated protein-kinase-21
    65(a)3
    67.46(n)1
    65.38(a)1
      1 5C13
    445731  NM_001201618.11  NP_001188547.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C44C8.6b3
    mak-21
    mak-21 59(a)
    (best of 2)3
    57.41(n)1
    59.4(a)1
      IV(884915-889900)3
    1769141  NM_067604.51  NP_500005.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RCK16
    RCK26
    Protein kinase involved in the response to oxidati...
    Protein kinase involved in the response to oxidati...
    20(a)
    17(a)
    many ↔ many
    many ↔ many
    VII(207033-208571) YGL158W
    XII(634252-636084) YLR248W


    ENSEMBL Gene Tree for MAPKAPK3 (if available)
    TreeFam Gene Tree for MAPKAPK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPKAPK3 gene
    RPS6KA62  MAPKAPK52  RPS6KA12  RPS6KA52  MAPKAPK22  RPS6KA42  MKNK12  MKNK22  
    RPS6KA32  RPS6KA22  
    Selected SIMAP similar genes for MAPKAPK3 using alignment to 5 protein entries:     MAPK3_HUMAN (see all proteins) (see all similar genes):
    MAPKAPK2    MARK4    MAPKAPK5    STK33    PNCK    RPS6KA1
    RPS6KA6    CAMK1    CAMKV    CAMK1D    DCLK3    RPS6KA2
    TRIB2    CAMK1G    CASK    NUAK1    RPS6KA5    STK17A

    Find genes that share paralogs with MAPKAPK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPKAPK3 (see all 619)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407554
    A glioblastoma multiforme sample4--see VAR_0407552 P S mis40--------
    rs1450757481,2
    --50651284(+) AGTAAC/TGGTTT 1 -- ut510--------
    rs7437531,2
    C,F,A,H--50651395(+) GCCCCC/TAGGCC 1 -- ut51 ese319Minor allele frequency- T:0.24NA EA NS WA 3784
    rs757017661,2
    F--50651396(+) CCCCCA/GGGCCT 1 -- ut511Minor allele frequency- G:0.04WA 118
    rs1509549731,2
    --50651400(+) CAGGCC/TTGTCC 1 -- ut510--------
    rs1407937211,2
    --50651455(+) GTCAGG/TGATTA 1 -- int10--------
    rs1504494251,2
    --50651464(+) TATGCA/GGTCTA 1 -- int10--------
    rs1453630221,2
    --50651615(+) CTCTGA/GCCAAC 1 -- int10--------
    rs1492086481,2
    C--50651665(+) CCCTGG/TCTCTG 1 -- int10--------
    rs1451682811,2
    --50651707(+) CCCCCA/TCTCAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MAPKAPK3 (50648951 - 50686720 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MAPKAPK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv990051CNV Insertion20482838
    nsv3815CNV Insertion18451855
    nsv508919CNV Insertion20534489
    esv1531131CNV Insertion17803354
    nsv460533CNV Loss19166990
    esv259700OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MAPKAPK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602130    OMIM disorders: --


    Find genes that share disorders with MAPKAPK3           About GenesLikeMe

    3 Novoseek inferred disease relationships for MAPKAPK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 45.4 3 9048659 (1), 12826286 (1), 9393975 (1)
    necrosis 19.3 1 8774846 (1)
    tumors 0 2 16367997 (1)

    Genetic Association Database (GAD): MAPKAPK3
    Human Genome Epidemiology (HuGE) Navigator: MAPKAPK3 (5 documents)

    Export disorders for MAPKAPK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPKAPK3 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with MAPKAPK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. (PubMed id 8626550)1, 2, 3, 9 McLaughlin M.M.... Young P.R. (J. Biol. Chem. 1996)
    2. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region. (PubMed id 8622688)1, 2, 3, 9 Sithanandam G.... Allikmets R. (Mol. Cell. Biol. 1996)
    3. A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C. (PubMed id 19208361)1, 4, 9 Tsukada H....Chayama K. (Gastroenterology 2009)
    4. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. (PubMed id 8774846)1, 2, 9 Clifton A.D.... Cohen P. (FEBS Lett. 1996)
    5. Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. (PubMed id 10781029)1, 2, 9 Neufeld B.... Rapp U.R. (J. Biol. Chem. 2000)
    6. Mitogen-activated 3p kinase is active in the nucleus. (PubMed id 15302577)1, 2, 9 Zakowski V.... Ludwig S. (Exp. Cell Res. 2004)
    7. High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand. (PubMed id 19937655)1, 2 Cheng R.... Hesterkamp T. (Protein Sci. 2010)
    8. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. (PubMed id 15563468)1, 2 Voncken J.W.... Rapp U.R. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7867 HGNC: 6888 AceView: MAPKAPK3 Ensembl:ENSG00000114738 euGenes: HUgn7867
    ECgene: MAPKAPK3 Kegg: 7867 H-InvDB: MAPKAPK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPKAPK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPKAPK3 gene:
    Search GeneIP for patents involving MAPKAPK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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