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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPKAPK3 Gene

protein-coding   GIFtS: 70
GCID: GC03P050648

Mitogen-Activated Protein Kinase-Activated Protein Kinase...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase-Activated Protein Kinase 31 2     EC 2.7.11.13 8
Chromosome 3p Kinase2 3     3PK2 5
MAPKAP-K32 3     MAPKAP32 5
MAPKAPK-32 3     MAP Kinase-Activated Protein Kinase 32
MK-32 3     3pK3
MAPK-Activated Protein Kinase 32 3     EC 2.7.118
MAPKAP Kinase 32 3     

External Ids:    HGNC: 68881   Entrez Gene: 78672   Ensembl: ENSG000001147387   OMIM: 6021305   UniProtKB: Q166443   

Export aliases for MAPKAPK3 gene to outside databases

Previous GC identifers: GC03M049300 GC03M049470 GC03P050509 GC03P050613 GC03P050624


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPKAPK3 Gene:
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated
protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular
signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was
shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK,
p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested
the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase
was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix
transcription factor known to be involved in the regulation of tissue-specific gene expression and cell
differentiation. Alternate splicing results in multiple transcript variants that encode the same protein.
(provided by RefSeq, Sep 2011)

GeneCards Summary for MAPKAPK3 Gene: 
MAPKAPK3 (mitogen-activated protein kinase-activated protein kinase 3) is a protein-coding gene. Diseases associated with MAPKAPK3 include saethre-chotzen syndrome, and hepatitis c, and among its related super-pathways are MAP kinase activation in TLR cascade and Signalling to RAS. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase kinase activity. An important paralog of this gene is MAPKAPK5.

UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644
Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell
migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and
activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the
peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same
function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower
compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates
phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small
heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against
oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6
production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as
TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36,
a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA
affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like
receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by
phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression

Gene Wiki entry for MAPKAPK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPKAPK3 gene promoter:
         STAT5B   GR   NRSF form 1   GR-beta   STAT5A   NRSF form 2   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPKAPK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPKAPK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPKAPK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.3

MAPKAPK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPKAPK3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P050648:  view genomic region     (about GC identifiers)

Start:
50,648,951 bp from pter      End:
50,686,720 bp from pter
Size:
37,770 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644 (See protein sequence)
Recommended Name: MAP kinase-activated protein kinase 3  
Size: 382 amino acids; 42987 Da
Subunit: Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex:
molecules are positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer
interface (By similarity). Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it
translocates to the cytoplasm
4 PDB 3D structures from and Proteopedia for MAPKAPK3:
3FHR (3D)        3FXW (3D)        3R1N (3D)        3SHE (3D)    
Secondary accessions: B5BU67

Explore the universe of human proteins at neXtProt for MAPKAPK3: NX_Q16644

Explore proteomics data for MAPKAPK3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1. Phosphorylated and activated by MAP kinase
    p38-alpha/MAPK14 at Thr-201, Ser-251 and Thr-313 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16644

  • 4/7 DME Specific Peptides for MAPKAPK3 (Q16644) (see all 7)
     TPYYVAP  AISPGMK  AFTEREA  TDFGFAK 

    MAPKAPK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAPKAPK3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001230854.1  NP_001230855.1  NP_004626.1  

    ENSEMBL proteins: 
     ENSP00000396467   ENSP00000410970   ENSP00000350639   ENSP00000402045   ENSP00000394894  
    Reactome Protein details: Q16644
    Human Recombinant Protein Products for MAPKAPK3: 
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    Novus Biologicals MAPKAPK3 Proteins
    Novus Biologicals MAPKAPK3 Lysate
    Sino Biological Recombinant Protein for MAPKAPK3
    Sino Biological Cell Lysate for MAPKAPK3 
    ProSpec Recombinant Protein for MAPKAPK3
    Cloud-Clone Corp. Proteins for MAPKAPK3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10781029
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0016020membrane ----

    MAPKAPK3 for ontologies           About GeneDecksing



    MAPKAPK3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPKAPK3
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    LSBio Antibodies in human, mouse, rat for MAPKAPK3 

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPKAPK3 
    Cloud-Clone Corp. CLIAs for MAPKAPK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase-activated protein kinase 3 
    MAPKAPK subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q16644

    ProtoNet protein and cluster: Q16644

    UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    MAPKAPK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAPK3_HUMAN, Q16644
    Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell
    migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and
    activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the
    peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same
    function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower
    compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates
    phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small
    heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against
    oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6
    production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as
    TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36,
    a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA
    affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like
    receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by
    phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited
    by ligand 5B
    (2'-[2-(1,3-benzodioxol-5-yl)pyrimidin-4-yl]-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]-
    4'(1'h)-one) and ligand P4O (2-[2-(2-fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro-
    4h-pyrrolo[3,2-c]pyridin-4-one), 2 ATP-competitive inhibitors

         Genatlas biochemistry entry for MAPKAPK3:
    mitogen-associated protein kinase-activated protein kinase,on a chromosome 3p segment,frequency deleted in small
    cell lung cancer

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15850461
    GO:0004708MAP kinase kinase activity TAS10781029
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    MAPKAPK3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MAPKAPK3:
     Decreased focal adhesion (FA)   Decreased nuclei size in G2M  Decreased substrate adherent c  Increased colony dispersion (i 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mapkapk3):
     embryogenesis  immune system  mortality/aging  no phenotypic analysis 

    MAPKAPK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mapkapk3tm1.1Lex for MAPKAPK3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAPKAPK3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAPKAPK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPKAPK3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPKAPK3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPKAPK3
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPKAPK3 (see all 12):
    hsa-miR-3140-3p hsa-miR-3065-3p hsa-miR-27a hsa-miR-128 hsa-miR-3065-5p hsa-miR-3681* hsa-miR-4299 hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmidMAPKAPK3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MAPKAPK3 (NM_004635)
    Sino Biological Human cDNA Clone for MAPKAPK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPKAPK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAPK3
    Sirion Biotech Customized lentivirus for stable overexpression of MAPKAPK3 
                         Customized lentivirus expression plasmids for stable overexpression of MAPKAPK3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAPK3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAPKAPK3 About   (see all 17)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 5 (TLR5) Cascade0.93
    MyD88-independent cascade 0.87
    MyD88 cascade initiated on plasma membrane0.93
    Toll Like Receptor 3 (TLR3) Cascade0.87
    Toll Like Receptor 10 (TLR10) Cascade0.93
    Toll Like Receptor 4 (TLR4) Cascade0.87
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll-Like Receptors Cascades0.87
    2Signalling to RAS
    Signalling to RAS0.73
    p38MAPK events0.48
    Signalling to ERKs0.73
    3Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    5VEGF Family Ligands and Receptor Interactions
    VEGF Pathway0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPKAPK3
        VEGF Pathway
    p38 Signaling
    Signaling Involved in Cardiac Hypertrophy
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPKAPK3
        MAP Kinase Signaling

    3 BioSystems Pathways for MAPKAPK3
        FAS pathway and Stress induction of HSP regulation
    Signaling mediated by p38-alpha and p38-beta
    p38 signaling mediated by MAPKAP kinases

    1 Sino Biological Pathway for MAPKAPK3 
        VEGF Signaling

    5/28        Reactome Pathways for MAPKAPK3 (see all 28)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 7/8 (TLR7/8) Cascade


    2         Kegg Pathways  (Kegg details for MAPKAPK3):
        MAPK signaling pathway
    VEGF signaling pathway


    MAPKAPK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPKAPK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/23 Interacting proteins for MAPKAPK3 (Q166441, 2, 3 ENSP000003506394) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZH2Q159102, 3, ENSP000003201474MINT-8262742 I2D: score=2 STRING: ENSP00000320147
    HSPB1P047921, 3, ENSP000002485534EBI-1384657,EBI-352682 I2D: score=2 STRING: ENSP00000248553
    COPS6Q7L5N12, 3MINT-8262731 I2D: score=2 
    SMSP527882, 3MINT-8262775 I2D: score=2 
    SUMO3P558542, 3MINT-8262786 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----

    MAPKAPK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPKAPK3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for MAPKAPK3

    Browse Tocris compounds for MAPKAPK3 (MAPK3)

    2 HMDB Compounds for MAPKAPK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for MAPKAPK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE-- --target--10592235
    2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE-- --target--10592235

    3 Novoseek inferred chemical compound relationships for MAPKAPK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 67.9 2 8626550 (1)
    mannitol 40.9 2 8626550 (1)
    serine 29.2 2 8774846 (1), 10383393 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPKAPK3 / MAPK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAPKAPK3 gene (3 alternative transcripts): 
    NM_001243925.1  NM_001243926.1  NM_004635.4  

    Unigene Cluster for MAPKAPK3:

    Mitogen-activated protein kinase-activated protein kinase 3
    Hs.234521  [show with all ESTs]
    Unigene Representative Sequence: NM_001243926
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486712 ENST00000446044(uc003day.2 uc010hlr.2) ENST00000497283
    ENST00000430409 ENST00000357955(uc003daz.2 uc003dba.2) ENST00000457064
    ENST00000451680
    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPKAPK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAPK3
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    Additional mRNA sequence: 

    AB451303.1 AB451434.1 AK290969.1 AK313565.1 BC001662.2 BC007591.1 BC010407.2 BC068497.1 
    U09578.1 U43784.1 

    7 DOTS entries:

    DT.97785686  DT.416016  DT.101970480  DT.100784697  DT.100784698  DT.100784695  DT.95369019 

    24/331 AceView cDNA sequences (see all 331):

    BU527991 AW732130 CA307066 BM904934 BM848086 BM792490 BU844643 AW615650 
    NM_004635 BG742083 BM908923 BM763538 BU854733 CR606251 BU146286 BU148701 
    U43784 CB158502 BQ719796 AA356809 BM694280 BU183682 BU167764 BQ957845 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
    SP1:                                                                                                        -     -                     
    SP2:                                                                                                                                    
    SP3:                                                              -                                                                     
    SP4:        -     -     -                                                                                                               
    SP5:                    -                                                                                                               


    ECgene alternative splicing isoforms for MAPKAPK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPKAPK3 expression in normal human tissues (normalized intensities)      MAPKAPK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGATAGGA
    MAPKAPK3 Expression
    About this image


    MAPKAPK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Thyroid (Endocrine System)
     
     Heart (Cardiovascular System)
     
     Blood (Hematopoietic System)

    See MAPKAPK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPKAPK3

    SOURCE GeneReport for Unigene cluster: Hs.234521

    UniProtKB/Swiss-Prot: MAPK3_HUMAN, Q16644
    Tissue specificity: Widely expressed, with a higher expression level observed in heart and skeletal muscle. No
    expression in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPKAPK3: 
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAPKAPK3 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapkapk31 , 5 mitogen-activated protein kinase-activated protein more1, 5 90.14(n)1
    94.76(a)1
      9 (57.98 cM)5
    1026261  NM_178907.31  NP_849238.11 
     1072549275 
    chicken
    (Gallus gallus)
    Aves MAPKAPK31 mitogen-activated protein kinase-activated protein more 76.09(n)
    85.08(a)
      415917  XM_414262.3  XP_414262.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAPKAPK36
    mitogen-activated protein kinase-activated protein...
    84(a)
    1 ↔ 1
    2(151606274-151726809)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.199142 Xenopus laevis transcribed sequence with moderate similarity more 79.57(n)    CD328653.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapkapk31 mitogen-activated protein kinase-activated protein more 71.35(n)
    77.03(a)
      790934  NM_001080079.1  NP_001073548.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MAPk-Ak21 , 3 protein amino acid phosphorylation
    protein kinase3
    MAP kinase activated protein-kinase-21
    65(a)3
    67.46(n)1
    65.38(a)1
      1 5C13
    445731  NM_001201618.11  NP_001188547.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C44C8.6b3
    mak-21
    Protein MAK-21 59(a)
    (best of 2)3
    57.73(n)1
    59.64(a)1
      IV(884915-889900)3
    1769141  NM_067604.41  NP_500005.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RCK16
    RCK26
    Protein kinase involved in the response to oxidati...
    Protein kinase involved in the response to oxidati...
    17(a)
    14(a)
    many ↔ many
    many ↔ many
    VII(207033-208571)
    XII(634252-636084)


    ENSEMBL Gene Tree for MAPKAPK3 (if available)
    TreeFam Gene Tree for MAPKAPK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPKAPK3 gene
    MAPKAPK52  MAPKAPK22  MKNK12  MKNK22  
    18/46 SIMAP similar genes for MAPKAPK3 using alignment to 5 protein entries:     MAPK3_HUMAN (see all proteins) (see all similar genes):
    MAPKAPK2    MARK4    MAPKAPK5    STK33    PNCK    RPS6KA1
    RPS6KA6    CAMK1    CAMKV    CAMK1D    DCLK3    RPS6KA2
    TRIB2    CAMK1G    CASK    NUAK1    RPS6KA5    STK17A

    MAPKAPK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/619 SNPs in MAPKAPK3 are shown (see all 619)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407554
    A glioblastoma multiforme sample4--see VAR_0407552 P S mis40--------
    VAR_0407564
    ----see VAR_0407562 E A mis40--------
    rs1450757481,2
    --50651284(+) AGTAAC/TGGTTT 1 -- ut510--------
    rs7437531,2
    C,F,A,H--50651395(+) GCCCCC/TAGGCC 1 -- ut51 ese319Minor allele frequency- T:0.24NA EA NS WA 3784
    rs757017661,2
    F--50651396(+) CCCCCA/GGGCCT 1 -- ut511Minor allele frequency- G:0.04WA 118
    rs1509549731,2
    --50651400(+) CAGGCC/TTGTCC 1 -- ut510--------
    rs1407937211,2
    --50651455(+) GTCAGG/TGATTA 1 -- int10--------
    rs1504494251,2
    --50651464(+) TATGCA/GGTCTA 1 -- int10--------
    rs1453630221,2
    --50651615(+) CTCTGA/GCCAAC 1 -- int10--------
    rs1492086481,2
    C--50651665(+) CCCTGG/TCTCTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MAPKAPK3 (50648951 - 50686720 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MAPKAPK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv990051CNV Insertion20482838
    nsv3815CNV Insertion18451855
    nsv508919CNV Insertion20534489
    esv1531131CNV Insertion17803354
    nsv460533CNV Loss19166990
    esv259700OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602130    OMIM disorders: --

    11 diseases for MAPKAPK3:    About MalaCards
    saethre-chotzen syndrome    hepatitis c    ischemia    lung cancer
    schizophrenia    alcoholism    endotheliitis    hepatitis
    melanoma    gastric cancer    pancreatitis


    MAPKAPK3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MAPKAPK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 45.4 3 9048659 (1), 12826286 (1), 9393975 (1)
    necrosis 19.3 1 8774846 (1)
    tumors 0 2 16367997 (1)

    Genetic Association Database (GAD): MAPKAPK3
    Human Genome Epidemiology (HuGE) Navigator: MAPKAPK3 (5 documents)

    Export disorders for MAPKAPK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPKAPK3 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with MAPKAPK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. (PubMed id 8626550)1, 2, 3, 9 McLaughlin M.M.... Young P.R. (1996)
    2. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region. (PubMed id 8622688)1, 2, 3, 9 Sithanandam G....Shrestha S. (1996)
    3. A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C. (PubMed id 19208361)1, 4, 9 Tsukada H....Chayama K. (2009)
    4. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. (PubMed id 8774846)1, 2, 9 Clifton A.D....Cohen P. (1996)
    5. Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. (PubMed id 10781029)1, 2, 9 Neufeld B.... Rapp U.R. (2000)
    6. Mitogen-activated 3p kinase is active in the nucleus. (PubMed id 15302577)1, 2, 9 Zakowski V.... Ludwig S. (2004)
    7. High-resolution crystal structure of human Mapkap kin ase 3 in complex with a high affinity ligand. (PubMed id 19937655)1, 2 Cheng R....Hesterkamp T. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (2009)
    10. MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. (PubMed id 15563468)1, 2 Voncken J.W.... Rapp U.R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7867 HGNC: 6888 AceView: MAPKAPK3 Ensembl:ENSG00000114738 euGenes: HUgn7867
    ECgene: MAPKAPK3 Kegg: 7867 H-InvDB: MAPKAPK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPKAPK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAPKAPK3 gene:
    Search GeneIP for patents involving MAPKAPK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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