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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPKAPK2 Gene

protein-coding   GIFtS: 69
GCID: GC01P206858

mitogen-activated protein kinase-activated protein kinase...
 Explore 22 diseases affiliated with
MAPKAPK2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAPKAPK2    

Aliases
for MAPKAPK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase-Activated Protein Kinase 21 2     MAPKAP Kinase 22 3
MAPKAP-K22 3     EC 2.7.11.13 8
MK-22 3     MAP Kinase-Activated Protein Kinase 22
MK22 3     MAPKAPK-23
MAPK-Activated Protein Kinase 22 3     EC 2.7.118

External Ids:    HGNC: 68871   Entrez Gene: 92612   Ensembl: ENSG000001628897   OMIM: 6020065   UniProtKB: P491373   

Export aliases for MAPKAPK2 gene to outside databases

Previous GC identifers: GC01P205518 GC01P202568 GC01P203501 GC01P203941 GC01P203246 GC01P204924 GC01P177556


Summaries
for MAPKAPK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPKAPK2:
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct
phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many
cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell
proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript
variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137
Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis,
reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and
transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14,
leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is
a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20,
LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in
response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair
their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory
response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating
AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and
translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF,
promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent
degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process
of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and
phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway
(TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3

Gene Wiki entry for MAPKAPK2


Genomic Views
for MAPKAPK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPKAPK2 gene promoter:
         CREB   AP-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAPKAPK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPKAPK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPKAPK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

MAPKAPK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPKAPK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206858:  view genomic region     (about GC identifiers)

Start:
 206,858,289 bp from pter      End:
 206,907,628 bp from pter
Size:
 49,340 bases      Orientation:
 plus strand

Proteins
for MAPKAPK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137 (See protein sequence)
Recommended Name: MAP kinase-activated protein kinase 2  
Size: 400 amino acids; 45568 Da
Subunit: Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex: molecules are
positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer interface. Interacts
with PHC2
Subcellular location: Cytoplasm. Nucleus. Note=Phosphorylation and subsequent activation releases the autoinhibitory
helix, resulting in the export from the nucleus into the cytoplasm
6/23 PDB 3D structures from and Proteopedia for MAPKAPK2 (see all 23):
1KWP (3D)        1NXK (3D)        1NY3 (3D)        2JBO (3D)        2JBP (3D)        2OKR (3D)    
Secondary accessions: Q5SY30 Q5SY41 Q8IYD6
Alternative splicing: 2 isoforms:  P49137-1   P49137-2   (Has a nuclear localization signal)

Explore the universe of human proteins at neXtProt for MAPKAPK2: NX_P49137

Post-translational modifications:

  • Sumoylation inhibits the protein kinase activity1
  • Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-222, Ser-272 and Thr-3341
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49137

    • 4/9 DME Specific Peptides for MAPKAPK2 (P49137) (see all 9)
     TDFGFAK  YVAPEVL  AISPGMK  TPYYVAP 

    MAPKAPK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004750.1  NP_116584.2  

    ENSEMBL proteins: 
     ENSP00000294981   ENSP00000356070  
    Reactome Protein details: P49137
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAPKAPK2 Protein
    R&D Systems Recombinant & Natural Proteins for MAPKAPK2
    Enzo Life Sciences proteins for MAPKAPK2
    OriGene Purified Protein: MAPKAPK2
    OriGene Protein Over-expression Lysate (see all 2): MAPKAPK2
    OriGene Custom Protein Services for MAPKAPK2 
    GenScript Custom Purified and Recombinant Proteins Services for MAPKAPK2
    Novus Biologicals MAPKAPK2 Proteins
    Novus Biologicals MAPKAPK2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAPKAPK2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--


    MAPKAPK2 for ontologies           About GeneDecksing



    MAPKAPK2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPKAPK2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MAPKAPK2 
    OriGene Antibodies (see all 2): MAPKAPK2
    OriGene Custom Antibody Services for MAPKAPK2 
    GenScript Custom Superior Antibodies Services for MAPKAPK2
    Novus Biologicals MAPKAPK2 Antibodies
    Abcam antibodies for MAPKAPK2 
    Uscn Antibodies for MAPKAPK2
    ThermoFisher Antibodies for MAPKAPK2

    Assay Products for MAPKAPK2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAPKAPK2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAPKAPK2

    Protein Domains /
    Families
    for MAPKAPK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPKAPK2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P49137

    ProtoNet protein and cluster: P49137

    UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Function
    for MAPKAPK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137
    Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis,
    reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and
    transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14,
    leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is
    a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20,
    LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in
    response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair
    their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory
    response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating
    AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and
    translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF,
    promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent
    degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process
    of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and
    phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway
    (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited
    following sumoylation. Specifically inhibited by pyrrolopyridine inhibitors

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): MAPKAPK2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPKAPK2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPKAPK2 (see all 18):
    hsa-miR-125a-5p hsa-miR-137 hsa-miR-485-3p hsa-miR-3692 hsa-miR-483-3p hsa-miR-9 hsa-miR-125b hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmid: MAPKAPK2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPKAPK2 (see all 7)
    OriGene shRNA RFP: MAPKAPK2
    OriGene siRNA: MAPKAPK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPKAPK2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPKAPK2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MAPKAPK2 (NM_004759)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPKAPK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAPK2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAPKAPK2
    Search LifeMap BioReagents cell lines for MAPKAPK2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAPK2

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS8179591
    GO:0004674protein serine/threonine kinase activity IDA--
    GO:0004871signal transducer activity TAS8179591
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    MAPKAPK2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MAPKAPK2:
     Decreased substrate adherent c  Decreased viability with TRAIL  Increased colony dispersion (i 

    Animal Models:
         Mouse knock-outs for MAPKAPK2: Mapkapk2tm1Mgl Mapkapk2tm1Lex
         10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mapkapk2):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle  normal 

    MAPKAPK2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPKAPK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/39 super-pathways (see all 39) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2Signalling to RAS
    		Signalling to RAS1.00
    		p38MAPK events0.48
    		Signalling to ERKs0.73
    3Cell cycle_Role of 14-3-3 proteins in cell cycle regulation
    		Cell cycle_Role of 14-3-3 proteins in cell cycle regulation1.00
    		Cell cycle Role of 14-3-3 proteins in cell cycle regulation1.00
    4Development FGFR signaling pathway
    		Development FGFR signaling pathway1.00
    		Development_FGFR signaling pathway0.98
    5Immune System
    		Immune System1.00
    		Innate Immune System0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for MAPKAPK2
        Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Development FGFR signaling pathway

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPKAPK2 (see all 6)
        MAPK Signaling
    VEGF Pathway
    IL-10 Pathway
    p38 Signaling
    Signaling Involved in Cardiac Hypertrophy

    1 Cell Signaling Technology (CST) Pathway for MAPKAPK2
        MAP Kinase Signaling

    3 GeneGo (Thomson Reuters) Pathways for MAPKAPK2
        Development VEGF signaling via VEGFR2 - generic cascades
    Development FGFR signaling pathway
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    5/13 BioSystems Pathways for MAPKAPK2 (see all 13) 
        Serotonin Receptor 4/6/7 and NR3C Signaling
    p38 MAPK Signaling Pathway
    MAPK signaling pathway
    Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
    FAS pathway and Stress induction of HSP regulation

    5/41        Reactome Pathways for MAPKAPK2 (see all 41)
        CREB phosphorylation
    Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    p38MAPK events
    Toll Like Receptor 3 (TLR3) Cascade


    3         Kegg Pathways  (Kegg details for MAPKAPK2):
        MAPK signaling pathway
    VEGF signaling pathway
    Neurotrophin signaling pathway


    MAPKAPK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPKAPK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for MAPKAPK2 (P491371, 2, 3 ENSP000003560704) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPB1P047921, 3, ENSP000002485534EBI-993299,EBI-352682 I2D: score=3 STRING: ENSP00000248553
    LIMK1P536672, 3, ENSP000003367404MINT-2833388 I2D: score=1 STRING: ENSP00000336740
    HSF1Q006131, 3EBI-993299,EBI-719620 I2D: score=2 
    MAPK14Q165391, 3, ENSP000002297944EBI-993299,EBI-73946 I2D: score=11 STRING: ENSP00000229794
    SHC1P293533, ENSP000004013034I2D: score=3 STRING: ENSP00000401303
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS8179591
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--


    MAPKAPK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPKAPK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPKAPK2 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPKAPK2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for MAPKAPK2

    Compounds for MAPKAPK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 3644022Potent MK-2 inhibitor[1276121-88-0]

    2 HMDB Compounds for MAPKAPK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 DrugBank Compounds for MAPKAPK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Staurosporine-- 62996-74-1target--17139284 17016423
    (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one-- --target--10592235
    (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one-- --target--10592235
    (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE-- --target--10592235
    2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE-- --target--10592235
    2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE-- --target--10592235
    3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione-- --target--10592235

    10/30 Novoseek chemical compound relationships for MAPKAPK2 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 82.7 19 11490018 (2), 18440775 (2), 9733787 (1), 12847121 (1) (see all 15)
    anisomycin 81.6 8 7487926 (1), 10347227 (1), 8805335 (1), 9933636 (1) (see all 8)
    lsp 1 64.8 5 8995217 (3), 17481585 (1)
    pd 169316 60.2 1 16876988 (1)
    sodium arsenite 58.2 1 12749847 (1)
    pd 98,059 50.7 1 10625698 (1)
    genistein 43.1 6 16772519 (5), 9815094 (1)
    threonine 42.7 7 7592979 (2), 8280084 (1), 9155018 (1), 7869766 (1)
    serine 41.9 8 8142647 (3), 8280084 (1), 7869766 (1), 8774846 (1) (see all 5)
    tyrosine 41.8 17 7744073 (4), 7901013 (2), 9753620 (2), 9374719 (2) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about MAPKAPK2 / MAPK2 

    Transcripts
    for MAPKAPK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPKAPK2 gene (2 alternative transcripts): 
    NM_004759.4  NM_032960.3  

    Unigene Cluster for MAPKAPK2:

    Mitogen-activated protein kinase-activated protein kinase 2
    Hs.643566  [show with all ESTs]
    Unigene Representative Sequence: NM_004759
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294981 ENST00000367103(uc001hel.2 uc001hem.2) ENST00000493447
    ENST00000479009

    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPKAPK2 (see all 18):
    hsa-miR-125a-5p hsa-miR-137 hsa-miR-485-3p hsa-miR-3692 hsa-miR-483-3p hsa-miR-9 hsa-miR-125b hsa-miR-3662
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK307499.1 BC036060.1 BC052584.1 X75346.1 

    15 DOTS entries:

    DT.454006  DT.100811676  DT.95312985  DT.87009494  DT.97816225  DT.102829833  DT.91950988  DT.92446830 
    DT.95246242  DT.95312986  DT.120656671  DT.87017080  DT.92446833  DT.95203380  DT.95312990 

    24/402 AceView cDNA sequences (see all 402):

    BU739585 AA446240 AA928556 BX401858 T16693 BQ425897 AI566320 AI285245 
    BM917012 BG255177 AA515688 CA335517 AA400246 CB529093 AI129958 BQ001766 
    BM713558 AI565403 BG422525 BU689030 AA910451 BU689472 CB321638 AA968718 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11
    SP1:                                                        -           -                                       
    SP2:                                                        -           -           -     -     -     -         
    SP3:                          -     -     -     -     -     -     -     -     -     -                           
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for MAPKAPK2

    Expression
    for MAPKAPK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPKAPK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCCCCCACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MAPKAPK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPKAPK2

    SOURCE GeneReport for Unigene cluster: Hs.643566

    UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137
    Tissue specificity: Expressed in all tissues examined

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPKAPK2: 
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for MAPKAPK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAPKAPK2 gene from 6/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAPKAPK21 mitogen-activated protein kinase-activated protein kinase 2 less 81.58(n)
    91.67(a)    		   419847  XM_417976.3  XP_417976.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPKAPK26
    		 --
    		 93(a)
    		 1 ↔ 1
    		 GL343228.1(1796740-1811248)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.135602 Xenopus laevis transcribed sequence with moderate similarity to protein spP49137 (H.sapiens) MKK2_HUMAN MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) less 76.36(n)    CA986314.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mapkapk22 mitogen-activated protein kinase-activated protein kinase 2 less 78.72(n)   327321  BC054572.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MAPk-Ak23 protein amino acid phosphorylation protein
    kinase less    		 63(a)   1 5C1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea C44C8.6b3   -- 56(a)
    (best of 2)    		   IV(884915-889900)   --


    ENSEMBL Gene Tree for MAPKAPK2 (if available)
    TreeFam Gene Tree for MAPKAPK2 (if available) 

    Paralogs
    for MAPKAPK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPKAPK2 gene
    MAPKAPK52  MAPKAPK32  MKNK12  MKNK22  
    18/28 SIMAP similar genes for MAPKAPK2 using alignment to 1 protein entry:     MAPK2_HUMAN(see all similar genes):
    MAPKAPK3    MAPKAPK5    RPS6KA5    CAMK1    MGC45428    RPS6KA1
    RPS6KA6    CAMK1D    CAMK4    PNCK    RPS6KA3    CAMK2G
    CDK4    DCLK2    RPS6KA2    STK33    MKNK1    PSKH2

    MAPKAPK2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAPKAPK2
    PGOHUM00000239844


    Genomic Variants
    for MAPKAPK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/820 NCBI SNPs in MAPKAPK2 are shown (see all 820)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs170141651,2
    		C,F,H,--177554761(+) AGACTC/TCAGAG 2 -- us2k119Minor allele frequency- T:0.05NA NS EA WA 2332
    rs170141761,2
    		C,F,H,--177554895(+) TGAAGA/GTGTTT 2 -- us2k1 tfbs318Minor allele frequency- G:0.08NA NS EA WA 2082
    rs801692491,2
    		F,--177554901(+) TGTTTT/CCCTAT 2 -- us2k11Minor allele frequency- C:0.03NA 120
    rs757151801,2
    		F,--177555042(+) TCGGGC/TTCCTA 2 -- us2k11Minor allele frequency- T:0.13WA 118
    rs741471541,2
    		C,--177555117(+) TCCACC/TGCTGC 2 -- us2k12Minor allele frequency- T:0.10WA 120
    rs178382741,2
    		C,F,H,--177555191(+) TGTGTC/TGGGGG 2 -- us2k113Minor allele frequency- T:0.06NA NS WA 1716
    rs730829041,2
    		C,--177555797(+) GTCTCG/TCTGTT 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs618156071,2
    		C,--177558417(+) AAGGCC/ATNNNN 2 -- int13Minor allele frequency- A:0.03NA EA 242
    rs741471551,2
    		C,--177558443(+) GCTCTC/TATACT 2 -- int12Minor allele frequency- T:0.03WA 120
    rs120927921,2
    		C,F,H,--177559086(+) GCTCCC/TAGATC 2 -- int16Minor allele frequency- T:0.05NS EA WA CSA 422

    HapMap Linkage Disequilibrium report for MAPKAPK2 (206858289 - 206907628 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for MAPKAPK2
         3 CNVs: 30450 71062 2091
    Human Gene Mutation Database (HGMD): MAPKAPK2

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    Disorders / Diseases
    for MAPKAPK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPKAPK2 for disorders           About GeneDecksing

    OMIM gene information: 602006    OMIM disorders: --

    20/22 diseases for MAPKAPK2 (see all 22):    About MalaCards
    monocytic leukemia    conjunctivitis    rheumatoid arthritis    tuberous sclerosis
    pheochromocytoma    multiple myeloma    pancreatic cancer    arthritis
    prostate cancer    breast cancer    ischemia    myeloma
    leukemia    alzheimer's disease    pancreatitis    breast carcinoma
    prostatitis    cerebritis    carcinoma    malaria

    10/13 Novoseek disease relationships for MAPKAPK2 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 57 37 1332886 (4), 7759569 (4), 8142647 (2), 8995217 (2) (see all 17)
    monocytic leukemia 39.7 1 7869766 (1)
    necrosis 18.6 5 8774846 (1), 10788429 (1), 7759569 (1), 11741878 (1) (see all 5)
    mimicry 13.8 1 11383510 (1)
    leukemia 0 1 8142647 (1)
    ischemia 0 3 9815094 (2), 8386729 (1)
    inflammation 0 3 17132859 (1), 12861023 (1), 19850376 (1)
    breast cancer 0 2 18469532 (1), 11857399 (1)
    pheochromocytoma 0 2 15389839 (1), 9753620 (1)
    rheumatoid arthritis 0 1 17480064 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAPKAPK2 (1 document)

    Export disorders for MAPKAPK2 gene to outside databases

    Publications
    for MAPKAPK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPKAPK2 gene, integrated from 9 sources (see all 243):
    (articles sorted by number of sources associating them with MAPKAPK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The primary structure of a human MAP kinase activated protein kinase 2. (PubMed id 8179591)1, 2, 3, 9 Zu Y.-L.... Huang C.K. (1994)
    2. The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. (PubMed id 8280084)1, 2, 3, 9 Stokoe D.... Cohen P. (1993)
    3. MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. (PubMed id 15629715)1, 2, 9 Manke I.A....Yaffe M.B. (2005)
    4. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. (PubMed id 8774846)1, 2, 9 Clifton A.D....Cohen P. (1996)
    5. Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export. (PubMed id 12171911)1, 2, 9 Meng W....Lippke J.A. (2002)
    6. Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. (PubMed id 8846784)1, 2, 9 Ben-Levy R....Cohen P. (1995)
    7. P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity. (PubMed id 15094067)1, 2, 9 Yannoni Y.M.... Lin L.L. (2004)
    8. MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization. (PubMed id 17481585)1, 2, 9 Wu Y....Madri J.A. (2007)
    9. Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. (PubMed id 17255097)1, 2, 9 ter Haar E....Lepre C. (2007)
    10. MK2 SUMOylation regulates actin filament remodeling a nd subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation. (PubMed id 21131586)1, 2 Chang E....Abe J. (2011)

    External Searches for MAPKAPK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAPKAPK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9261 HGNC: 6887 AceView: MAPKAPK2 Ensembl:ENSG00000162889 euGenes: HUgn9261
    ECgene: MAPKAPK2 Kegg: 9261 H-InvDB: MAPKAPK2

    Other Databases showing MAPKAPK2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAPKAPK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPKAPK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPKAPK2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAPKAPK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPKAPK2 gene:
    Search GeneIP for patents involving MAPKAPK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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