Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAPKAPK2 Gene

Aliases for MAPKAPK2 Gene

  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 2 3 5
  • MAPK-Activated Protein Kinase 2 3 4
  • MAPKAP Kinase 2 3 4
  • EC 2.7.11.1 4 58
  • MAPKAP-K2 3 4
  • MK-2 3 4
  • MK2 3 4
  • MAP Kinase-Activated Protein Kinase 2 3
  • MAPKAPK-2 4
  • EC 2.7.11 58

External Ids for MAPKAPK2 Gene

Previous GeneCards Identifiers for MAPKAPK2 Gene

  • GC01P205518
  • GC01P202568
  • GC01P203501
  • GC01P203941
  • GC01P203246
  • GC01P204924
  • GC01P206858
  • GC01P177556

Summaries for MAPKAPK2 Gene

Entrez Gene Summary for MAPKAPK2 Gene

  • This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPKAPK2 Gene

MAPKAPK2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2) is a Protein Coding gene. Among its related pathways are Activated TLR4 signalling and p38MAPK events. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPKAPK3.

UniProtKB/Swiss-Prot for MAPKAPK2 Gene

  • Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

Tocris Summary for MAPKAPK2 Gene

  • Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2, or MK2) is a kinase belonging to the MAPKAPK family, a group of kinases activated by MAPK signaling. MK2 is activated by p38alpha and regulates the production of inflammatory cytokines, such as TNF-alpha.

Gene Wiki entry for MAPKAPK2 Gene

Additional gene information for MAPKAPK2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPKAPK2 Gene

Genomics for MAPKAPK2 Gene

Regulatory Elements for MAPKAPK2 Gene

Enhancers for MAPKAPK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H206917 1.9 FANTOM5 Ensembl ENCODE dbSUPER 25.6 +238.2 238159 11 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 CDCA4P4 EIF2D MAPKAPK2 ENSG00000271680 CD46 PIGR FCAMR RPL7AP20 IL20 IL19
GH01H206573 2 FANTOM5 Ensembl ENCODE dbSUPER 21 -106.2 -106151 11 HDGF PKNOX1 ATF1 ARNT ZNF2 YY1 ZNF766 GATA2 ELK1 ZNF207 RASSF5 EIF2D MAPKAPK2 IKBKE ELK4 C1orf147 DYRK3 IL19 FCMR PIR41610
GH01H206722 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +38.8 38776 2 TBP SIN3A BRCA1 RAD21 RFX5 YY1 RCOR1 FOS DEK EGR2 MAPKAPK2 IL19 IL10 FCMR PIGR IL24 IL20 DYRK3 RASSF5 GC01M206749
GH01H207048 1.7 Ensembl ENCODE dbSUPER 14.8 +368.0 368032 9 HDGF FOXA2 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 CDCA4P4 EIF2D MAPKAPK2 C1orf116 CR1 RPL7AP20 PFKFB2 YOD1
GH01H206586 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -95.6 -95636 6 CTCF ATF1 ARNT JUN RAD21 FOSL1 ZNF664 CC2D1A CTBP1 POLR2A RASSF5 EIF2D MAPKAPK2 C1orf147 IKBKE PIR41610 ENSG00000279946
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAPKAPK2 on UCSC Golden Path with GeneCards custom track

Promoters for MAPKAPK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019020 688 2401 HDGF ATF1 ARID4B SIN3A BRCA1 ZNF766 GLIS2 ELK1 ZNF207 ATF7

Transcription factor binding sites by QIAGEN in the MAPKAPK2 gene promoter:

Genomic Location for MAPKAPK2 Gene

Chromosome:
1
Start:
206,684,912 bp from pter
End:
206,734,285 bp from pter
Size:
49,374 bases
Orientation:
Plus strand

Genomic View for MAPKAPK2 Gene

Genes around MAPKAPK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPKAPK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPKAPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPKAPK2 Gene

Proteins for MAPKAPK2 Gene

  • Protein details for MAPKAPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49137-MAPK2_HUMAN
    Recommended name:
    MAP kinase-activated protein kinase 2
    Protein Accession:
    P49137
    Secondary Accessions:
    • Q5SY30
    • Q5SY41
    • Q8IYD6

    Protein attributes for MAPKAPK2 Gene

    Size:
    400 amino acids
    Molecular mass:
    45568 Da
    Quaternary structure:
    • Heterodimer with p38-alpha/MAPK14; this heterodimer forms a stable complex: molecules are positioned face to face so that the ATP-binding sites of both kinases are at the heterodimer interface (PubMed:12171911, PubMed:17576063, PubMed:17255097, PubMed:17480064, PubMed:17449059, PubMed:17395714). Interacts with PHC2 (PubMed:15094067). Interacts with HSF1 (PubMed:16278218).

    Three dimensional structures from OCA and Proteopedia for MAPKAPK2 Gene

    Alternative splice isoforms for MAPKAPK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPKAPK2 Gene

Selected DME Specific Peptides for MAPKAPK2 Gene

P49137:
  • CLLIVMEC
  • AISPGMK
  • NIAHRDVKPENLLYTSK
  • YVAPEVL
  • AFTEREA
  • TDFGFAK
  • PEWSEVSE
  • TPYYVAP
  • MTITEFMNHPWIMQSTKVPQTPLHTSR

Post-translational modifications for MAPKAPK2 Gene

  • Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-222, Ser-272 and Thr-334.
  • Sumoylation inhibits the protein kinase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPKAPK2 Gene

Domains & Families for MAPKAPK2 Gene

Gene Families for MAPKAPK2 Gene

Suggested Antigen Peptide Sequences for MAPKAPK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49137

UniProtKB/Swiss-Prot:

MAPK2_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAPKAPK2: view

Function for MAPKAPK2 Gene

Molecular function for MAPKAPK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited following sumoylation. Specifically inhibited by pyrrolopyridine inhibitors.
UniProtKB/Swiss-Prot Function:
Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

Enzyme Numbers (IUBMB) for MAPKAPK2 Gene

Phenotypes From GWAS Catalog for MAPKAPK2 Gene

Gene Ontology (GO) - Molecular Function for MAPKAPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity TAS 8179591
GO:0004674 protein serine/threonine kinase activity EXP,TAS --
GO:0004683 calmodulin-dependent protein kinase activity IBA --
GO:0004871 signal transducer activity TAS 8179591
genes like me logo Genes that share ontologies with MAPKAPK2: view
genes like me logo Genes that share phenotypes with MAPKAPK2: view

Animal Models for MAPKAPK2 Gene

MGI Knock Outs for MAPKAPK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPKAPK2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAPKAPK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPKAPK2 Gene

Localization for MAPKAPK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPKAPK2 Gene

Cytoplasm. Nucleus. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPKAPK2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAPKAPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 20932473
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 20932473
GO:0005813 centrosome IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPKAPK2: view

Pathways & Interactions for MAPKAPK2 Gene

SuperPathways for MAPKAPK2 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 RET signaling
3 CDK-mediated phosphorylation and removal of Cdc6
4 Cellular Senescence (REACTOME)
5 Nuclear Events (kinase and transcription factor activation)
genes like me logo Genes that share pathways with MAPKAPK2: view

SIGNOR curated interactions for MAPKAPK2 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPKAPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS 8179591
GO:0000187 activation of MAPK activity TAS --
GO:0002224 toll-like receptor signaling pathway IEA,ISS --
GO:0006468 protein phosphorylation TAS 8179591
GO:0006691 leukotriene metabolic process TAS --
genes like me logo Genes that share ontologies with MAPKAPK2: view

Drugs & Compounds for MAPKAPK2 Gene

(29) Drugs for MAPKAPK2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one Experimental Pharma Target 0
(3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one Experimental Pharma Target 0
(4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE Experimental Pharma Target 0
2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE Experimental Pharma Target 0
2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE Experimental Pharma Target 0

(11) Additional Compounds for MAPKAPK2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) Tocris Compounds for MAPKAPK2 Gene

Compound Action Cas Number
PF 3644022 Potent MK2 inhibitor 1276121-88-0

(2) ApexBio Compounds for MAPKAPK2 Gene

Compound Action Cas Number
Chk1 and MK2 Inhibitors set Chk1- and MK2 inhibitors
PF-3644022 Potent and Selective MK2 inhibitor 1276121-88-0
genes like me logo Genes that share compounds with MAPKAPK2: view

Drug Products

Transcripts for MAPKAPK2 Gene

Unigene Clusters for MAPKAPK2 Gene

Mitogen-activated protein kinase-activated protein kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAPKAPK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11
SP1: - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4:

Relevant External Links for MAPKAPK2 Gene

GeneLoc Exon Structure for
MAPKAPK2
ECgene alternative splicing isoforms for
MAPKAPK2

Expression for MAPKAPK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPKAPK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPKAPK2 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for MAPKAPK2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.8), Spleen (7.3), and Stomach (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPKAPK2 Gene



Protein tissue co-expression partners for MAPKAPK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAPKAPK2 Gene:

MAPKAPK2

SOURCE GeneReport for Unigene cluster for MAPKAPK2 Gene:

Hs.643566

mRNA Expression by UniProt/SwissProt for MAPKAPK2 Gene:

P49137-MAPK2_HUMAN
Tissue specificity: Expressed in all tissues examined.

Evidence on tissue expression from TISSUES for MAPKAPK2 Gene

  • Skin(4.4)
  • Liver(4.3)
  • Heart(3.1)
  • Muscle(3.1)
  • Lung(2.9)
  • Bone marrow(2.3)
  • Nervous system(2.3)
  • Kidney(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with MAPKAPK2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPKAPK2 Gene

Orthologs for MAPKAPK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPKAPK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPKAPK2 33 34
  • 99.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAPKAPK2 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPKAPK2 33 34
  • 91.9 (n)
dog
(Canis familiaris)
Mammalia MAPKAPK2 33 34
  • 91.27 (n)
rat
(Rattus norvegicus)
Mammalia Mapkapk2 33
  • 90.08 (n)
mouse
(Mus musculus)
Mammalia Mapkapk2 33 16 34
  • 89.9 (n)
oppossum
(Monodelphis domestica)
Mammalia MAPKAPK2 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPKAPK2 33 34
  • 82.65 (n)
lizard
(Anolis carolinensis)
Reptilia MAPKAPK2 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapkapk2 33
  • 77.1 (n)
Str.1027 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13560 33
zebrafish
(Danio rerio)
Actinopterygii mapkapk2a 33 34
  • 77.52 (n)
mapkapk2b 34
  • 67 (a)
OneToMany
mapkapk2 33
fruit fly
(Drosophila melanogaster)
Insecta MAPk-Ak2 35 34
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea C44C8.6a 35
  • 56 (a)
C44C8.6b 35
  • 56 (a)
mak-2 34
  • 54 (a)
ManyToMany
mak-1 34
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 34
  • 20 (a)
ManyToMany
RCK2 34
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6967 33
Species where no ortholog for MAPKAPK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPKAPK2 Gene

ENSEMBL:
Gene Tree for MAPKAPK2 (if available)
TreeFam:
Gene Tree for MAPKAPK2 (if available)

Paralogs for MAPKAPK2 Gene

Paralogs for MAPKAPK2 Gene

genes like me logo Genes that share paralogs with MAPKAPK2: view

Variants for MAPKAPK2 Gene

Sequence variations from dbSNP and Humsavar for MAPKAPK2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000030915 -- 206,712,056(+) AATGT(G/T)AAGTA intron-variant
rs1000183881 -- 206,707,928(+) TCTTT(A/G)ATTCC intron-variant
rs1000344518 -- 206,701,878(+) TGAGG(A/T)CTACA intron-variant
rs1000628383 -- 206,703,039(+) GCTCC(C/T)TGCGG intron-variant
rs1000698161 -- 206,701,648(+) GAGCA(A/G)CATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPKAPK2 Gene

Variant ID Type Subtype PubMed ID
esv21658 CNV loss 19812545
nsv1068832 CNV deletion 25765185
nsv549069 CNV loss 21841781
nsv8713 CNV gain 18304495
nsv946616 CNV duplication 23825009
nsv952651 CNV deletion 24416366

Variation tolerance for MAPKAPK2 Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.49; 95.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPKAPK2 Gene

Human Gene Mutation Database (HGMD)
MAPKAPK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPKAPK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKAPK2 Gene

Disorders for MAPKAPK2 Gene

Relevant External Links for MAPKAPK2

Genetic Association Database (GAD)
MAPKAPK2
Human Genome Epidemiology (HuGE) Navigator
MAPKAPK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPKAPK2

No disorders were found for MAPKAPK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPKAPK2 Gene

Publications for MAPKAPK2 Gene

  1. The primary structure of a human MAP kinase activated protein kinase 2. (PMID: 8179591) Zu YL … Huang CK (Biochemical and biophysical research communications 1994) 2 3 4 22 60
  2. The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. (PMID: 8280084) Stokoe D … Cohen P (The Biochemical journal 1993) 2 3 4 22 60
  3. MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization. (PMID: 17481585) Wu Y … Madri JA (Biochemical and biophysical research communications 2007) 3 4 22 60
  4. Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. (PMID: 17255097) ter Haar E … Lepre C (The Journal of biological chemistry 2007) 3 4 22 60
  5. MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. (PMID: 15629715) Manke IA … Yaffe MB (Molecular cell 2005) 3 4 22 60

Products for MAPKAPK2 Gene

Sources for MAPKAPK2 Gene

Content
Loading form....