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MAPKAPK2 Gene

protein-coding   GIFtS: 72
GCID: GC01P206858

Mitogen-Activated Protein Kinase-Activated Protein Kinase...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase-Activated Protein Kinase 21 2     MAPKAP Kinase 22 3
MK22 3 5     EC 2.7.11.13 8
MAPKAP-K22 3     MAP Kinase-Activated Protein Kinase 22
MK-22 3     MAPKAPK-23
MAPK-Activated Protein Kinase 22 3     EC 2.7.118

External Ids:    HGNC: 68871   Entrez Gene: 92612   Ensembl: ENSG000001628897   OMIM: 6020065   UniProtKB: P491373   

Export aliases for MAPKAPK2 gene to outside databases

Previous GC identifers: GC01P205518 GC01P202568 GC01P203501 GC01P203941 GC01P203246 GC01P204924 GC01P177556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPKAPK2 Gene:
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct
phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in
many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation
and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo.
Two transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for MAPKAPK2 Gene:
MAPKAPK2 (mitogen-activated protein kinase-activated protein kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is RPS6KA6.

UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137
Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis,
reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response
and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase
p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence,
Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0,
HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates
phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small
heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against
oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6
production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1,
HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs.
Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3
proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing
transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional
mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and
PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic
cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3

Gene Wiki entry for MAPKAPK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPKAPK2 gene promoter:
         CREB   AP-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPKAPK2 promoter sequence
   Search Chromatin IP Primers for MAPKAPK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPKAPK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

MAPKAPK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPKAPK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206858:  view genomic region     (about GC identifiers)

Start:
206,858,289 bp from pter      End:
206,907,628 bp from pter
Size:
49,340 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137 (See protein sequence)
Recommended Name: MAP kinase-activated protein kinase 2  
Size: 400 amino acids; 45568 Da
Subunit: Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex:
molecules are positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer
interface. Interacts with PHC2
Selected PDB 3D structures from and Proteopedia for MAPKAPK2 (see all 24):
1KWP (3D)        1NXK (3D)        1NY3 (3D)        2JBO (3D)        2JBP (3D)        2OKR (3D)    
Secondary accessions: Q5SY30 Q5SY41 Q8IYD6
Alternative splicing: 2 isoforms:  P49137-1   P49137-2   (Has a nuclear localization signal)

Explore the universe of human proteins at neXtProt for MAPKAPK2: NX_P49137

Explore proteomics data for MAPKAPK2 at MOPED

Post-translational modifications: 

  • Sumoylation inhibits the protein kinase activity1
  • Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-222, Ser-272 and Thr-3341
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPKAPK2 (P49137) (see all 9)
     TDFGFAK  YVAPEVL  AISPGMK  TPYYVAP 


    See MAPKAPK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004750.1  NP_116584.2  

    ENSEMBL proteins: 
     ENSP00000294981   ENSP00000356070  
    Reactome Protein details: P49137

    MAPKAPK2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MAPKAPK2
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    Novus Biologicals MAPKAPK2 Proteins
    Novus Biologicals MAPKAPK2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAPKAPK2

     
    Search eBioscience for Proteins for MAPKAPK2 

     
    antibodies-online proteins for MAPKAPK2 (9 products) 

     
    antibodies-online peptides for MAPKAPK2

    MAPKAPK2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPKAPK2
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    antibodies-online antibodies for MAPKAPK2 (204 products) 

    MAPKAPK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPKAPK2
    Cloud-Clone Corp. CLIAs for MAPKAPK2
    Search eBioscience for ELISAs for MAPKAPK2 
    antibodies-online kits for MAPKAPK2 (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase-activated protein kinase 2
    MAPKAPK subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P49137

    ProtoNet protein and cluster: P49137

    UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAPKAPK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAPK2_HUMAN, P49137
    Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis,
    reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response
    and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase
    p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence,
    Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0,
    HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates
    phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small
    heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against
    oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6
    production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1,
    HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs.
    Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3
    proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing
    transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional
    mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and
    PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic
    cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited
    following sumoylation. Specifically inhibited by pyrrolopyridine inhibitors

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS8179591
    GO:0004674protein serine/threonine kinase activity IDA14517288
    GO:0004713protein tyrosine kinase activity ----
    GO:0004871signal transducer activity TAS8179591
    GO:0005515protein binding IPI14517288
         
    Find genes that share ontologies with MAPKAPK2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAPKAPK2:
     Decreased substrate adherent c  Decreased viability with TRAIL  Increased colony dispersion (i 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mapkapk2):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle  normal 
     tumorigenesis 

    Find genes that share phenotypes with MAPKAPK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mapkapk2tm1Mgl for MAPKAPK2

       genOway: Develop your customized and physiologically relevant rodent model for MAPKAPK2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPKAPK2:
    hsa-mir-615-3p (MIRT040005), hsa-mir-1229-3p (MIRT036373), hsa-mir-124-3p (MIRT022202), hsa-mir-324-5p (MIRT043144), hsa-mir-193b-3p (MIRT041511)

    Block miRNA regulation of human, mouse, rat MAPKAPK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPKAPK2 (see all 18):
    hsa-miR-125a-5p hsa-miR-137 hsa-miR-485-3p hsa-miR-3692 hsa-miR-483-3p hsa-miR-9 hsa-miR-125b hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidMAPKAPK2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAPKAPK2

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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPKAPK2
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    Addgene plasmids for MAPKAPK2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAPK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAPK2_HUMAN, P49137: Cytoplasm. Nucleus. Note=Phosphorylation and subsequent activation releases the
    autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    Find genes that share ontologies with MAPKAPK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPKAPK2 About   (see all 34)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP Kinase Signaling0.31
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    activated TAK1 mediates p38 MAPK activation0.00
    MAP kinase activation in TLR cascade0.61
    CREB phosphorylation0.00
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Immune response Fc epsilon RI pathway
    VEGF signaling pathway0.39
    VEGF - VEGF R2 Signaling Pathways0.35
    4Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    5Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81


    Find genes that share SuperPaths with MAPKAPK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MAPKAPK2
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPKAPK2 (see all 6)
        MAPK Signaling
    VEGF Pathway
    IL-10 Pathway
    p38 Signaling
    Signaling Involved in Cardiac Hypertrophy

    1 Cell Signaling Technology (CST) Pathway for MAPKAPK2
        MAP Kinase Signaling

    3 GeneGo (Thomson Reuters) Pathways for MAPKAPK2
        Development VEGF signaling via VEGFR2 - generic cascades
    Development FGFR signaling pathway
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    Selected BioSystems Pathways for MAPKAPK2 (see all 13)
        MAPK signaling pathway
    Serotonin Receptor 4/6/7 and NR3C Signaling
    FAS pathway and Stress induction of HSP regulation
    Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
    p38 MAPK Signaling Pathway

    Selected Reactome Pathways for MAPKAPK2 (see all 8)
        activated TAK1 mediates p38 MAPK activation
    Oxidative Stress Induced Senescence
    CREB phosphorylation
    Tristetraprolin (TTP) destabilizes mRNA
    p38MAPK events


    4 Kegg Pathways  (Kegg details for MAPKAPK2):
        MAPK signaling pathway
    VEGF signaling pathway
    Neurotrophin signaling pathway
    Viral carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPKAPK2: 
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPKAPK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPKAPK2 (P491371, 2, 3 ENSP000003560704) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSF1Q006131, 3EBI-993299,EBI-719620 I2D: score=2 
    MAPK14Q165391, 3, ENSP000002297944EBI-993299,EBI-73946 I2D: score=11 STRING: ENSP00000229794
    HSPB1P047921, 3, ENSP000002485534EBI-993299,EBI-352682 I2D: score=3 STRING: ENSP00000248553
    LIMK1P536672, 3, ENSP000003367404MINT-2833388 I2D: score=1 STRING: ENSP00000336740
    SHC1P293533, ENSP000004013034I2D: score=3 STRING: ENSP00000401303
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 41):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS8179591
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    Find genes that share ontologies with MAPKAPK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MAPKAPK2
      Browse compounds at ApexBio 

    Compounds for MAPKAPK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 3644022Potent MK2 inhibitor[1276121-88-0]
    NQDI 1Inhibitor of apoptosis signal-regulating kinase 1 (ASK1)[175026-96-7]
    HI TOPK 032Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor[487020-03-1]

    2 HMDB Compounds for MAPKAPK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 DrugBank Compounds for MAPKAPK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Staurosporine-- 62996-74-1target--17139284 17016423
    (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one-- --target--10592235
    (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one-- --target--10592235
    (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE-- --target--10592235
    2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE-- --target--10592235
    2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE-- --target--10592235
    3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for MAPKAPK2 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 82.7 19 11490018 (2), 18440775 (2), 9733787 (1), 12847121 (1) (see all 15)
    anisomycin 81.6 8 7487926 (1), 10347227 (1), 8805335 (1), 9933636 (1) (see all 8)
    lsp 1 64.8 5 8995217 (3), 17481585 (1)
    pd 169316 60.2 1 16876988 (1)
    sodium arsenite 58.2 1 12749847 (1)
    pd 98,059 50.7 1 10625698 (1)
    genistein 43.1 6 16772519 (5), 9815094 (1)
    threonine 42.7 7 7592979 (2), 8280084 (1), 9155018 (1), 7869766 (1)
    serine 41.9 8 8142647 (3), 8280084 (1), 7869766 (1), 8774846 (1) (see all 5)
    tyrosine 41.8 17 7744073 (4), 7901013 (2), 9753620 (2), 9374719 (2) (see all 8)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAPKAPK2 gene (2 alternative transcripts): 
    NM_004759.4  NM_032960.3  

    Unigene Cluster for MAPKAPK2:

    Mitogen-activated protein kinase-activated protein kinase 2
    Hs.643566  [show with all ESTs]
    Unigene Representative Sequence: NM_004759
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294981 ENST00000367103(uc001hel.2 uc001hem.2) ENST00000493447
    ENST00000479009
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    hsa-miR-125a-5p hsa-miR-137 hsa-miR-485-3p hsa-miR-3692 hsa-miR-483-3p hsa-miR-9 hsa-miR-125b hsa-miR-3662
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    Additional mRNA sequence: 

    AK307499.1 BC036060.1 BC052584.1 X75346.1 

    15 DOTS entries:

    DT.454006  DT.100811676  DT.95312985  DT.87009494  DT.97816225  DT.102829833  DT.91950988  DT.92446830 
    DT.95246242  DT.95312986  DT.120656671  DT.87017080  DT.92446833  DT.95203380  DT.95312990 

    Selected AceView cDNA sequences (see all 402):

    AA968718 BU681156 AI288550 BU689030 AA232461 CA445097 BC052584 CK724950 
    CN479985 BE378442 BM468011 BM678604 BU621325 AA910451 AA446240 AW272374 
    AA400246 AI565403 BQ069490 BE907084 BM683161 BU527041 AI566320 AA505747 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11
    SP1:                                                        -           -                                       
    SP2:                                                        -           -           -     -     -     -         
    SP3:                          -     -     -     -     -     -     -     -     -     -                           
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for MAPKAPK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPKAPK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCCCACT
    MAPKAPK2 Expression
    About this image


    MAPKAPK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gall Bladder (Hepatobiliary System)
    MAPKAPK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPKAPK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643566

    UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137
    Tissue specificity: Expressed in all tissues examined

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPKAPK2: 
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              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAPKAPK2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapkapk21 , 5 MAP kinase-activated protein kinase 21, 5 89.9(n)1
    97.73(a)1
      1 (56.89 cM)5
    171641  NM_008551.11  NP_032577.11 
     1310537045 
    chicken
    (Gallus gallus)
    Aves MAPKAPK21 mitogen-activated protein kinase-activated protein kinase 2 less 82.65(n)
    93.02(a)
      419847  XM_417976.4  XP_417976.4 
    lizard
    (Anolis carolinensis)
    Reptilia MAPKAPK26
    mitogen-activated protein kinase-activated protein...
    87(a)
    1 ↔ 1
    GL343228.1(1708353-1811248)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135602 Xenopus laevis transcribed sequence with moderate similarity to protein spP49137 (H.sapiens) MKK2_HUMAN MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) less 76.36(n)    CA986314.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapkapk22 mitogen-activated protein kinase-activated protein kinase 2 less 78.72(n)   327321  BC054572.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MAPk-Ak23 protein amino acid phosphorylation
    protein kinase less
    63(a)   1 5C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea C44C8.6b3   -- 56(a)
    (best of 2)
      IV(884915-889900)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RCK16
    RCK26
    Protein kinase involved in the response to oxidati...
    Protein kinase involved in the response to oxidati...
    20(a)
    18(a)
    many ↔ many
    many ↔ many
    VII(207033-208571) YGL158W
    XII(634252-636084) YLR248W


    ENSEMBL Gene Tree for MAPKAPK2 (if available)
    TreeFam Gene Tree for MAPKAPK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPKAPK2 gene
    RPS6KA62  MAPKAPK32  MAPKAPK52  RPS6KA12  RPS6KA52  RPS6KA42  MKNK12  MKNK22  
    RPS6KA32  RPS6KA22  
    Selected SIMAP similar genes for MAPKAPK2 using alignment to 1 protein entry:     MAPK2_HUMAN(see all similar genes):
    MAPKAPK3    MAPKAPK5    RPS6KA5    CAMK1    MGC45428    RPS6KA1
    RPS6KA6    CAMK1D    CAMK4    PNCK    RPS6KA3    CAMK2G
    CDK4    DCLK2    RPS6KA2    STK33    MKNK1    PSKH2

    Find genes that share paralogs with MAPKAPK2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MAPKAPK2
    PGOHUM00000239844


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPKAPK2 (see all 1000)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs800084201,2
    C--177604969(+) GTGTGC/TGCACA 2 -- ut310--------
    rs583988051,2
    C--206864409(+) AGCAA-/CCCACA 2 -- int10--------
    rs359066351,2
    C--206865556(+) TGTGT-/GGCTGG 2 -- int10--------
    rs593683061,2
    C--206873306(+) TCTCT-/CTCT  
            
    TCTTT
    2 -- int10--------
    rs711524841,2
    C--206879496(+) TATTT-/ATT   
       TATTT
    ATTTA
    4 -- int11Minor allele frequency- ATTTATTT:0.00NA 2
    rs583799671,2
    C--206886350(+) CACAC-/ACAC/ACACACA
    C
    /ACACACACACAC
    TAATA
    8 -- int1 cds11NA 2
    rs711524851,2
    C--206888110(+) AAAAA-/AGAAGT 2 -- int11Minor allele frequency- A:0.00NA 2
    rs347555281,2
    C--206888974(+) TTTTTT/-GAGAT 2 -- int12Minor allele frequency- -:0.25NA 4
    rs359624181,2
    C--206891215(+) AAGAA-/AAAAAA 2 -- int11Minor allele frequency- A:0.50NA 2
    rs114317191,2
    C--206895411(+) CAAAAA/-AAAAA 2 -- int1 trp31Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for MAPKAPK2 (206858289 - 206907628 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MAPKAPK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv21658CNV Loss19812545
    nsv8713CNV Gain18304495
    nsv873128CNV Gain21882294

    Human Gene Mutation Database (HGMD): MAPKAPK2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPKAPK2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPKAPK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602006    OMIM disorders: --


    Find genes that share disorders with MAPKAPK2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MAPKAPK2 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 57 37 1332886 (4), 7759569 (4), 8142647 (2), 8995217 (2) (see all 17)
    monocytic leukemia 39.7 1 7869766 (1)
    necrosis 18.6 5 8774846 (1), 10788429 (1), 7759569 (1), 11741878 (1) (see all 5)
    mimicry 13.8 1 11383510 (1)
    leukemia 0 1 8142647 (1)
    ischemia 0 3 9815094 (2), 8386729 (1)
    inflammation 0 3 17132859 (1), 12861023 (1), 19850376 (1)
    breast cancer 0 2 18469532 (1), 11857399 (1)
    pheochromocytoma 0 2 15389839 (1), 9753620 (1)
    rheumatoid arthritis 0 1 17480064 (1)

    Genetic Association Database (GAD): MAPKAPK2
    Human Genome Epidemiology (HuGE) Navigator: MAPKAPK2 (1 document)

    Export disorders for MAPKAPK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPKAPK2 gene, integrated from 10 sources (see all 258):
    (articles sorted by number of sources associating them with MAPKAPK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The primary structure of a human MAP kinase activated protein kinase 2. (PubMed id 8179591)1, 2, 3, 9 Zu Y.-L.... Huang C.K. (Biochem. Biophys. Res. Commun. 1994)
    2. The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. (PubMed id 8280084)1, 2, 3, 9 Stokoe D.... Cohen P. (Biochem. J. 1993)
    3. MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. (PubMed id 15629715)1, 2, 9 Manke I.A.... Yaffe M.B. (Mol. Cell 2005)
    4. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. (PubMed id 8774846)1, 2, 9 Clifton A.D.... Cohen P. (FEBS Lett. 1996)
    5. Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export. (PubMed id 12171911)1, 2, 9 Meng W.... Lippke J.A. (J. Biol. Chem. 2002)
    6. Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. (PubMed id 8846784)1, 2, 9 Ben-Levy R.... Cohen P. (EMBO J. 1995)
    7. P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity. (PubMed id 15094067)1, 2, 9 Yannoni Y.M.... Lin L.L. (FEBS Lett. 2004)
    8. MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization. (PubMed id 17481585)1, 2, 9 Wu Y....Madri J.A. (Biochem. Biophys. Res. Commun. 2007)
    9. MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration. (PubMed id 16456544)1, 2, 9 Kobayashi M.... Mizuno K. (EMBO J. 2006)
    10. Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. (PubMed id 17255097)1, 2, 9 ter Haar E.... Lepre C. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9261 HGNC: 6887 AceView: MAPKAPK2 Ensembl:ENSG00000162889 euGenes: HUgn9261
    ECgene: MAPKAPK2 Kegg: 9261 H-InvDB: MAPKAPK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAPKAPK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPKAPK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPKAPK2 gene:
    Search GeneIP for patents involving MAPKAPK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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