MAPKAPK2 Gene
protein-coding GIFtS: 69
GCID: GC01P206858
|
|
mitogen-activated protein kinase-activated protein kinase...
| |
Aliases
for MAPKAPK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitogen-Activated Protein Kinase-Activated Protein Kinase 21 2 | | MAPKAP Kinase 22 3 | | MAPKAP-K22 3 | | EC 2.7.11.13 8 | | MK-22 3 | | MAP Kinase-Activated Protein Kinase 22 | | MK22 3 | | MAPKAPK-23 | | MAPK-Activated Protein Kinase 22 3 | | EC 2.7.118 |
Export aliases for MAPKAPK2 gene to outside databasesPrevious GC identifers: GC01P205518 GC01P202568 GC01P203501 GC01P203941 GC01P203246 GC01P204924 GC01P177556 |
Summaries
for MAPKAPK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAPKAPK2:
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through directphosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in manycellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cellproliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcriptvariants encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis,reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response andtranscriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14,leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd isa large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20,LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 inresponse to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairtheir chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatoryresponse by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylatingAU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability andtranslation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF,promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependentdegradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a processof post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm andphosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway(TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3
Gene Wiki entry for MAPKAPK2
|
Genomic Views
for MAPKAPK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAPKAPK2 gene promoter:
CREB AP-1 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAPKAPK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPKAPK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32MAPKAPK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P206858: view genomic region
(about GC identifiers)
Start:
|
206,858,289 bp from pter |
End:
|
206,907,628 bp from pter |
Size:
|
49,340 bases |
Orientation:
|
plus strand |
|
Proteins
for MAPKAPK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137 (See
protein sequence)Recommended Name: MAP kinase-activated protein kinase 2 Size: 400 amino acids; 45568 Da
Subunit: Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex: molecules arepositioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer interface. Interactswith PHC2
Subcellular location: Cytoplasm. Nucleus. Note=Phosphorylation and subsequent activation releases the autoinhibitoryhelix, resulting in the export from the nucleus into the cytoplasm
6/23 PDB 3D structures from  and Proteopedia  for MAPKAPK2 (see all 23):1KWP (3D)
1NXK (3D)
1NY3 (3D)
2JBO (3D)
2JBP (3D)
2OKR (3D)
Secondary accessions: Q5SY30 Q5SY41 Q8IYD6Alternative splicing: 2 isoforms: P49137-1 P49137-2 (Has a nuclear localization signal)Explore the universe of human proteins at neXtProt for MAPKAPK2: NX_P49137
Post-translational modifications:
Sumoylation inhibits the protein kinase activity1
Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-222, Ser-272 and Thr-3341
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49137
4/9 DME Specific Peptides for MAPKAPK2 (P49137) (see all 9)
MAPKAPK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004750.1 NP_116584.2
ENSEMBL proteins: ENSP00000294981 ENSP00000356070 Reactome Protein details: P49137
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MAPKAPK2 for ontologies About GeneDecksing
MAPKAPK2 Antibody Products:
Assay Products for MAPKAPK2: |
Protein
Domains /
Families
for MAPKAPK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAPKAPK2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P49137ProtoNet protein and cluster: P49137 UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for MAPKAPK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis,reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response andtranscriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14,leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd isa large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20,LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 inresponse to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairtheir chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatoryresponse by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylatingAU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability andtranslation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF,promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependentdegradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a processof post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm andphosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway(TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibitedfollowing sumoylation. Specifically inhibited by pyrrolopyridine inhibitorsEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK2 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MAPKAPK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAPK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAPK2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
MAPKAPK2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for MAPKAPK2:
Animal Models:
Mouse knock-outs for MAPKAPK2: Mapkapk2tm1Mgl Mapkapk2tm1Lex
10 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Mapkapk2):
MAPKAPK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAPKAPK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/39 super-pathways (see all 39) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | Signalling to RAS | | | 3 | Cell cycle_Role of 14-3-3 proteins in cell cycle regulation | | | 4 | Development FGFR signaling pathway | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for MAPKAPK2
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPKAPK2 (see all 6)
1 
Cell Signaling Technology (CST) Pathway for MAPKAPK2
3  GeneGo (Thomson Reuters) Pathways for MAPKAPK2
5/13  BioSystems Pathways for MAPKAPK2 (see all 13)
5/41 
Reactome Pathways for MAPKAPK2 (see all 41)
3 
Kegg Pathways (Kegg details for MAPKAPK2):
MAPKAPK2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPKAPK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/61 Interacting proteins for MAPKAPK2 (P491371, 2, 3 ENSP000003560704) via UniProtKB, MINT, STRING, and/or I2D (see all 61)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| HSPB1 | P047921, 3, ENSP000002485534 | EBI-993299,EBI-352682 I2D:
score=3 STRING: ENSP00000248553 | | LIMK1 | P536672, 3, ENSP000003367404 | MINT-2833388 I2D:
score=1 STRING: ENSP00000336740 | | HSF1 | Q006131, 3 | EBI-993299,EBI-719620 I2D:
score=2 | | MAPK14 | Q165391, 3, ENSP000002297944 | EBI-993299,EBI-73946 I2D:
score=11 STRING: ENSP00000229794 | | SHC1 | P293533, ENSP000004013034 | I2D:
score=3 STRING: ENSP00000401303 |
About this table
Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000165 | MAPK cascade |
TAS | 8179591 | | GO:0000187 | activation of MAPK activity |
TAS | -- | | GO:0002224 | toll-like receptor signaling pathway |
TAS | -- | | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
TAS | -- | | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- |
MAPKAPK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAPKAPK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MAPKAPK2 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for MAPKAPK2 |
 Compounds for MAPKAPK2 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| PF 3644022 | Potent MK-2 inhibitor | [1276121-88-0] |
2 HMDB Compounds for MAPKAPK2 About this table
8 DrugBank Compounds for MAPKAPK2 About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| Adenosine-5'-Diphosphate | -- | 20398-34-9 | target | -- | 17139284 17016423 | | Staurosporine | -- | 62996-74-1 | target | -- | 17139284 17016423 | | (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one | -- | -- | target | -- | 10592235 | | (3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one | -- | -- | target | -- | 10592235 | | (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE | -- | -- | target | -- | 10592235 | | 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | -- | -- | target | -- | 10592235 | | 2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE | -- | -- | target | -- | 10592235 | | 3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione | -- | -- | target | -- | 10592235 |
10/30 Novoseek chemical compound relationships for MAPKAPK2 gene (see all 30) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sb 203580 |
82.7 |
19 |
11490018 (2), 18440775 (2), 9733787 (1), 12847121 (1) (see all 15) |
| anisomycin |
81.6 |
8 |
7487926 (1), 10347227 (1), 8805335 (1), 9933636 (1) (see all 8) |
| lsp 1 |
64.8 |
5 |
8995217 (3), 17481585 (1) |
| pd 169316 |
60.2 |
1 |
16876988 (1) |
| sodium arsenite |
58.2 |
1 |
12749847 (1) |
| pd 98,059 |
50.7 |
1 |
10625698 (1) |
| genistein |
43.1 |
6 |
16772519 (5), 9815094 (1) |
| threonine |
42.7 |
7 |
7592979 (2), 8280084 (1), 9155018 (1), 7869766 (1) |
| serine |
41.9 |
8 |
8142647 (3), 8280084 (1), 7869766 (1), 8774846 (1) (see all 5) |
| tyrosine |
41.8 |
17 |
7744073 (4), 7901013 (2), 9753620 (2), 9374719 (2) (see all 8) |
Search CenterWatch for drugs/clinical trials and news about MAPKAPK2 / MAPK2
|
Transcripts
for MAPKAPK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAPKAPK2 gene (2 alternative transcripts): NM_004759.4 NM_032960.3 Unigene Cluster for MAPKAPK2: Mitogen-activated protein kinase-activated protein kinase 2 Hs.643566 [show with all ESTs]Unigene Representative Sequence: NM_0047594 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000294981 ENST00000367103(uc001hel.2 uc001hem.2) ENST00000493447
ENST00000479009
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK2 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MAPKAPK2 (NM_004759) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAPKAPK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAPK2 |
Additional cDNA sequence: AK307499.1 BC036060.1 BC052584.1 X75346.1 15 DOTS entries: DT.454006 DT.100811676 DT.95312985 DT.87009494 DT.97816225 DT.102829833 DT.91950988 DT.92446830 DT.95246242 DT.95312986 DT.120656671 DT.87017080 DT.92446833 DT.95203380 DT.95312990 24/402 AceView cDNA sequences (see all 402): BU739585 AA446240 AA928556 BX401858 T16693 BQ425897 AI566320 AI285245 BM917012 BG255177 AA515688 CA335517 AA400246 CB529093 AI129958 BQ001766 BM713558 AI565403 BG422525 BU689030 AA910451 BU689472 CB321638 AA968718
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | - | | - | | - | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAPKAPK2
|
Expression
for MAPKAPK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAPKAPK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCCCACT
About this image
See MAPKAPK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAPKAPK2
SOURCE GeneReport for Unigene cluster: Hs.643566
UniProtKB/Swiss-Prot: MAPK2_HUMAN, P49137Tissue specificity: Expressed in all tissues examined
SABiosciences Expression via Pathway-Focused PCR Arrays including MAPKAPK2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPKAPK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPKAPK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPKAPK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPKAPK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAPK2 |
Orthologs
for MAPKAPK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAPKAPK2 gene from 6/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MAPKAPK21 |
mitogen-activated protein kinase-activated protein more |
81.58(n)
91.67(a) |
|
419847 XM_417976.3 XP_417976.3 |
lizard
(Anolis carolinensis) |
Reptilia |
MAPKAPK26 |
-- |
93(a) |
1 ↔ 1 |
GL343228.1(1796740-1811248) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.135602 |
Xenopus laevis transcribed sequence with moderate similarity more |
76.36(n) |
|
CA986314.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
mapkapk22 |
mitogen-activated protein kinase-activated protein more |
78.72(n) |
|
327321 BC054572.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAPk-Ak23 |
protein amino acid phosphorylation protein
kinase |
63(a) |
|
1 5C1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
C44C8.6b3 |
-- |
56(a)
(best of 2) |
|
IV(884915-889900) -- |
ENSEMBL Gene Tree for MAPKAPK2 (if available)
TreeFam Gene Tree for MAPKAPK2 (if available) |
Paralogs
for MAPKAPK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAPKAPK2 gene
- MAPKAPK52 MAPKAPK32 MKNK12 MKNK22
18/28 SIMAP similar genes for MAPKAPK2 using alignment to 1 protein entry: MAPK2_HUMAN(see all similar genes):MAPKAPK3 MAPKAPK5 RPS6KA5 CAMK1 MGC45428 RPS6KA1
RPS6KA6 CAMK1D CAMK4 PNCK RPS6KA3 CAMK2G
CDK4 DCLK2 RPS6KA2 STK33 MKNK1 PSKH2
MAPKAPK2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MAPKAPK2
PGOHUM00000239844
|
Genomic Variants
for MAPKAPK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAPKAPK2 (206858289 - 206907628 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MAPKAPK2
3 CNVs: 30450 71062 2091
Human Gene Mutation Database (HGMD): MAPKAPK2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPKAPK2 |
|
Disorders
/ Diseases
for MAPKAPK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAPKAPK2 for disorders About GeneDecksing
OMIM gene information: 602006
OMIM disorders: --
20/22  diseases for MAPKAPK2 (see all 22): About MalaCardsmonocytic leukemia conjunctivitis rheumatoid arthritis tuberous sclerosis
pheochromocytoma multiple myeloma pancreatic cancer arthritis
prostate cancer breast cancer ischemia myeloma
leukemia alzheimer's disease pancreatitis breast carcinoma
prostatitis cerebritis carcinoma malaria
10/13 Novoseek disease relationships for MAPKAPK2 gene (see all 13) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| shock |
57 |
37 |
1332886 (4), 7759569 (4), 8142647 (2), 8995217 (2) (see all 17) |
| monocytic leukemia |
39.7 |
1 |
7869766 (1) |
| necrosis |
18.6 |
5 |
8774846 (1), 10788429 (1), 7759569 (1), 11741878 (1) (see all 5) |
| mimicry |
13.8 |
1 |
11383510 (1) |
| leukemia |
0 |
1 |
8142647 (1) |
| ischemia |
0 |
3 |
9815094 (2), 8386729 (1) |
| inflammation |
0 |
3 |
17132859 (1), 12861023 (1), 19850376 (1) |
| breast cancer |
0 |
2 |
18469532 (1), 11857399 (1) |
| pheochromocytoma |
0 |
2 |
15389839 (1), 9753620 (1) |
| rheumatoid arthritis |
0 |
1 |
17480064 (1) |
Human Genome Epidemiology (HuGE) Navigator: MAPKAPK2 (1 document)
Export disorders for MAPKAPK2 gene to outside databases
|
Publications
for MAPKAPK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAPKAPK2 gene, integrated from 9 sources (see all 243):
(articles sorted by number of sources associating them with MAPKAPK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The primary structure of a human MAP kinase activated protein kinase 2. (PubMed id 8179591)1, 2, 3, 9 Zu Y.-L.... Huang C.K. (1994)
- The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. (PubMed id 8280084)1, 2, 3, 9 Stokoe D.... Cohen P. (1993)
- MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. (PubMed id 15629715)1, 2, 9 Manke I.A....Yaffe M.B. (2005)
- A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. (PubMed id 8774846)1, 2, 9 Clifton A.D....Cohen P. (1996)
- Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export. (PubMed id 12171911)1, 2, 9 Meng W....Lippke J.A. (2002)
- Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. (PubMed id 8846784)1, 2, 9 Ben-Levy R....Cohen P. (1995)
- P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity. (PubMed id 15094067)1, 2, 9 Yannoni Y.M.... Lin L.L. (2004)
- MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization. (PubMed id 17481585)1, 2, 9 Wu Y....Madri J.A. (2007)
- Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. (PubMed id 17255097)1, 2, 9 ter Haar E....Lepre C. (2007)
- MK2 SUMOylation regulates actin filament remodeling a nd subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation. (PubMed id 21131586)1, 2 Chang E....Abe J. (2011)
|
External Searches for MAPKAPK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAPKAPK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAPKAPK2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAPKAPK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAPKAPK2 gene:
Search GeneIP for patents involving MAPKAPK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAPKAPK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MAPKAPK2 | | OriGene shRNA RFP for MAPKAPK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPKAPK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPKAPK2 | | | OriGene Protein Over-expression Lysate for MAPKAPK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAPKAPK2 | | OriGene 3'-UTR Clone for MAPKAPK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAPK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MAPKAPK2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAPKAPK2 | | OriGene Custom Protein Services for MAPKAPK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAPKAPK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPKAPK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPKAPK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPKAPK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPKAPK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPKAPK2 |
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 | | | MAPKAPK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAPK2 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAPK2 |
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