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Aliases for MAPKAPK2 Gene

Aliases for MAPKAPK2 Gene

  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 2 3
  • MK2 3 4 6
  • MAPK-Activated Protein Kinase 2 3 4
  • MAPKAP Kinase 2 3 4
  • EC 2.7.11.1 4 63
  • MAPKAP-K2 3 4
  • MK-2 3 4
  • MAP Kinase-Activated Protein Kinase 2 3
  • MAPKAPK-2 4
  • EC 2.7.11 63

External Ids for MAPKAPK2 Gene

Previous GeneCards Identifiers for MAPKAPK2 Gene

  • GC01P205518
  • GC01P202568
  • GC01P203501
  • GC01P203941
  • GC01P203246
  • GC01P204924
  • GC01P206858
  • GC01P177556

Summaries for MAPKAPK2 Gene

Entrez Gene Summary for MAPKAPK2 Gene

  • This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPKAPK2 Gene

MAPKAPK2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is MKNK2.

UniProtKB/Swiss-Prot for MAPKAPK2 Gene

  • Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

Tocris Summary for MAPKAPK2 Gene

Gene Wiki entry for MAPKAPK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPKAPK2 Gene

Genomics for MAPKAPK2 Gene

Regulatory Elements for MAPKAPK2 Gene

Transcription factor binding sites by QIAGEN in the MAPKAPK2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAPKAPK2 Gene

Start:
206,684,944 bp from pter
End:
206,734,285 bp from pter
Size:
49,342 bases
Orientation:
Plus strand

Genomic View for MAPKAPK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPKAPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPKAPK2 Gene

Proteins for MAPKAPK2 Gene

  • Protein details for MAPKAPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49137-MAPK2_HUMAN
    Recommended name:
    MAP kinase-activated protein kinase 2
    Protein Accession:
    P49137
    Secondary Accessions:
    • Q5SY30
    • Q5SY41
    • Q8IYD6

    Protein attributes for MAPKAPK2 Gene

    Size:
    400 amino acids
    Molecular mass:
    45568 Da
    Quaternary structure:
    • Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex: molecules are positioned face to face so that the ATP-binding sites of both kinases are at the heterodimer interface. Interacts with PHC2.

    Three dimensional structures from OCA and Proteopedia for MAPKAPK2 Gene

    Alternative splice isoforms for MAPKAPK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPKAPK2 Gene

Proteomics data for MAPKAPK2 Gene at MOPED

Post-translational modifications for MAPKAPK2 Gene

  • Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-222, Ser-272 and Thr-334.
  • Sumoylation inhibits the protein kinase activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPKAPK2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPKAPK2 (MAPKAPK2)

Domains for MAPKAPK2 Gene

Suggested Antigen Peptide Sequences for MAPKAPK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49137

UniProtKB/Swiss-Prot:

MAPK2_HUMAN :
  • P49137
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with MAPKAPK2: view

Function for MAPKAPK2 Gene

Molecular function for MAPKAPK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited following sumoylation. Specifically inhibited by pyrrolopyridine inhibitors
UniProtKB/Swiss-Prot Function: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

Enzyme Numbers (IUBMB) for MAPKAPK2 Gene

Gene Ontology (GO) - Molecular Function for MAPKAPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 8179591
GO:0004674 protein serine/threonine kinase activity IDA 14517288
GO:0004683 calmodulin-dependent protein kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0004871 signal transducer activity TAS 8179591
genes like me logo Genes that share ontologies with MAPKAPK2: view
genes like me logo Genes that share phenotypes with MAPKAPK2: view

Animal Models for MAPKAPK2 Gene

MGI Knock Outs for MAPKAPK2:

Animal Model Products

CRISPR Products

miRNA for MAPKAPK2 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for MAPKAPK2 Gene

Localization for MAPKAPK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPKAPK2 Gene

Cytoplasm. Nucleus. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPKAPK2 Gene COMPARTMENTS Subcellular localization image for MAPKAPK2 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MAPKAPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20932473
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 20932473
GO:0005813 centrosome IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPKAPK2: view

Pathways for MAPKAPK2 Gene

genes like me logo Genes that share pathways with MAPKAPK2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MAPKAPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS 8179591
GO:0000187 activation of MAPK activity TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MAPKAPK2: view

Compounds for MAPKAPK2 Gene

(4) Tocris Compounds for MAPKAPK2 Gene

Compound Action Cas Number
HI TOPK 032 Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor [487020-03-1]
NQDI 1 Inhibitor of apoptosis signal-regulating kinase 1 (ASK1) [175026-96-7]
PF 3644022 Potent MK2 inhibitor [1276121-88-0]
PHA 767491 hydrochloride Dual cdc7/cdk9 inhibitor. Also inhibits MK2 [942425-68-5]

(2) HMDB Compounds for MAPKAPK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(30) Novoseek inferred chemical compound relationships for MAPKAPK2 Gene

Compound -log(P) Hits PubMed IDs
sb 203580 82.7 17
anisomycin 81.6 8
lsp 1 64.8 4
pd 169316 60.2 1
sodium arsenite 58.2 1
genes like me logo Genes that share compounds with MAPKAPK2: view

Transcripts for MAPKAPK2 Gene

Unigene Clusters for MAPKAPK2 Gene

Mitogen-activated protein kinase-activated protein kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPKAPK2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAPK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11
SP1: - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4:

Relevant External Links for MAPKAPK2 Gene

GeneLoc Exon Structure for
MAPKAPK2
ECgene alternative splicing isoforms for
MAPKAPK2

Expression for MAPKAPK2 Gene

mRNA expression in normal human tissues for MAPKAPK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPKAPK2 Gene

This gene is overexpressed in Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPKAPK2 Gene

SOURCE GeneReport for Unigene cluster for MAPKAPK2 Gene Hs.643566

mRNA Expression by UniProt/SwissProt for MAPKAPK2 Gene

P49137-MAPK2_HUMAN
Tissue specificity: Expressed in all tissues examined
genes like me logo Genes that share expressions with MAPKAPK2: view

In Situ Assay Products

Orthologs for MAPKAPK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPKAPK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPKAPK2 35
  • 99.75 (n)
  • 99.75 (a)
MAPKAPK2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPKAPK2 35
  • 91.9 (n)
  • 98.59 (a)
MAPKAPK2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPKAPK2 35
  • 91.27 (n)
  • 97.16 (a)
MAPKAPK2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapkapk2 35
  • 89.9 (n)
  • 97.73 (a)
Mapkapk2 16
Mapkapk2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPKAPK2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPKAPK2 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapkapk2 35
  • 90.08 (n)
  • 97.45 (a)
chicken
(Gallus gallus)
Aves MAPKAPK2 35
  • 82.65 (n)
  • 93.02 (a)
MAPKAPK2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPKAPK2 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13560 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mapkapk2 35
  • 77.1 (n)
  • 90.06 (a)
Str.1027 35
zebrafish
(Danio rerio)
Actinopterygii mapkapk2 35
mapkapk2a 35
  • 77.52 (n)
  • 89.15 (a)
mapkapk2a 36
  • 83 (a)
OneToMany
mapkapk2b 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta MAPk-Ak2 36
  • 62 (a)
OneToMany
MAPk-Ak2 37
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea mak-1 36
  • 31 (a)
ManyToMany
mak-2 36
  • 54 (a)
ManyToMany
C44C8.6a 37
  • 56 (a)
C44C8.6b 37
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCK1 36
  • 20 (a)
ManyToMany
RCK2 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6967 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for MAPKAPK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPKAPK2 Gene

ENSEMBL:
Gene Tree for MAPKAPK2 (if available)
TreeFam:
Gene Tree for MAPKAPK2 (if available)

Paralogs for MAPKAPK2 Gene

Selected SIMAP similar genes for MAPKAPK2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MAPKAPK2 Gene

genes like me logo Genes that share paralogs with MAPKAPK2: view

Variants for MAPKAPK2 Gene

Sequence variations from dbSNP and Humsavar for MAPKAPK2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7868 -- 206,734,137(-) TGGGC(A/G)CCCCT utr-variant-3-prime
rs1130514 -- 206,733,129(+) CATCT(G/T)CCCTC utr-variant-3-prime
rs1130528 -- 206,734,043(+) GCTGT(C/T)TGTGC utr-variant-3-prime
rs3189432 -- 206,732,630(+) CAAGA(A/T)AAAAG utr-variant-3-prime, missense, reference
rs3189439 -- 206,733,400(+) TGCTG(A/G)GGCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAPKAPK2 Gene

Variant ID Type Subtype PubMed ID
nsv873128 CNV Gain 21882294
nsv8713 CNV Gain 18304495
esv21658 CNV Loss 19812545

Relevant External Links for MAPKAPK2 Gene

HapMap Linkage Disequilibrium report
MAPKAPK2
Human Gene Mutation Database (HGMD)
MAPKAPK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPKAPK2 Gene

Disorders for MAPKAPK2 Gene

(13) Novoseek inferred disease relationships for MAPKAPK2 Gene

Disease -log(P) Hits PubMed IDs
shock 57 27
monocytic leukemia 39.7 1
necrosis 18.6 5
mimicry 13.8 1
leukemia 0 1

Relevant External Links for MAPKAPK2

Genetic Association Database (GAD)
MAPKAPK2
Human Genome Epidemiology (HuGE) Navigator
MAPKAPK2
genes like me logo Genes that share disorders with MAPKAPK2: view

No data available for UniProtKB/Swiss-Prot for MAPKAPK2 Gene

Publications for MAPKAPK2 Gene

  1. The primary structure of a human MAP kinase activated protein kinase 2. (PMID: 8179591) Zu Y.-L. … Huang C.K. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23
  2. The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. (PMID: 8280084) Stokoe D. … Cohen P. (Biochem. J. 1993) 2 3 4 23
  3. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. (PMID: 8774846) Clifton A.D. … Cohen P. (FEBS Lett. 1996) 3 4 23
  4. Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. (PMID: 8846784) Ben-Levy R. … Cohen P. (EMBO J. 1995) 3 4 23
  5. Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export. (PMID: 12171911) Meng W. … Lippke J.A. (J. Biol. Chem. 2002) 3 4 23

Products for MAPKAPK2 Gene

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