MAPKAP1 Gene
protein-coding GIFtS: 56
GCID: GC09M128199
|
|
mitogen-activated protein kinase associated protein 1
| |
Aliases
for MAPKAP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitogen-Activated Protein Kinase Associated Protein 11 2 | | JC3102 | | MIP11 2 3 | | SIN1b2 | | SIN11 2 3 | | SIN1g2 | | Mitogen-Activated Protein Kinase 2-Associated Protein 12 3 | | MEKK2-Interacting Protein 12 | | Stress-Activated Map Kinase-Interacting Protein 12 3 | | Ras Inhibitor MGC27452 | | MSIN11 | | Stress-Activated Map Kinase Interacting Protein 12 | | SAPK-Interacting Protein 12 3 | | Stress-Activated Protein Kinase-Interacting 12 | | TORC2 Subunit MAPKAP12 3 | | Target Of Rapamycin Complex 2 Subunit MAPKAP12 | | MGC27451 | | |
Export aliases for MAPKAP1 gene to outside databasesPrevious GC identifers: GC09M119314 GC09M119846 GC09M121653 GC09M123576 GC09M125280 GC09M127239 GC09M097812 |
Summaries
for MAPKAP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAPKAP1:
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase.Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylationsites as well as alternate 3' UTRs have been identified for transcripts of this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 isactivated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to functionupstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guaninenucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays acritical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop ofAKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required forcomplex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization andautophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 andATF2-mediated transcription
Gene Wiki entry for MAPKAP1
|
Genomic Views
for MAPKAP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAPKAP1 gene promoter:
ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAPKAP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPKAP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q33.3 Ensembl cytogenetic band: 9q33.3 HGNC cytogenetic band: 9q34.11MAPKAP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M128199: view genomic region
(about GC identifiers)
Start:
|
128,199,672 bp from pter |
End:
|
128,469,513 bp from pter |
Size:
|
269,842 bases |
Orientation:
|
minus strand |
|
Proteins
for MAPKAP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7 (See
protein sequence)Recommended Name: Target of rapamycin complex 2 subunit MAPKAP1 Size: 522 amino acids; 59123 Da
Subunit: Interacts with IFNAR2 (By similarity). All isoforms except isoform 4 can be incorporated into the mammaliantarget of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary tomTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8.Interacts with GTP-bound HRAS and KRAS. Interacts with SGK1 (By similarity)
Subcellular location: Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus
1 PDB 3D structure from  and Proteopedia  for MAPKAP1:3VOQ (3D)
Secondary accessions: A8K1Z5 B1AMA4 B7Z309 Q00426 Q5JSV5 Q5JSV6 Q5JSV9 Q658R0 Q699U1 Q699U2 Q699U3Q699U4 Q6GVJ0 Q6GVJ1 Q6GVJ2Alternative splicing: 6 isoforms: Q9BPZ7-1 Q9BPZ7-2 Q9BPZ7-3 Q9BPZ7-4 Q9BPZ7-5 Q9BPZ7-6 (Not involved in a TORC2 complex)Explore the universe of human proteins at neXtProt for MAPKAP1: NX_Q9BPZ7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BPZ7
MAPKAP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001006618.1 NP_001006619.1 NP_001006620.1 NP_001006621.1 NP_001006622.1 NP_077022.1
ENSEMBL proteins: ENSP00000362610 ENSP00000265961 ENSP00000362602 ENSP00000362597 ENSP00000412485 ENSP00000418607 ENSP00000400182 ENSP00000377624 ENSP00000408359 ENSP00000417766 ENSP00000362595 ENSP00000390024 ENSP00000265960 ENSP00000377627 ENSP00000362596 Reactome Protein details: Q9BPZ7
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MAPKAP1 for ontologies About GeneDecksing
MAPKAP1 Antibody Products:
Assay Products for MAPKAP1: |
Protein
Domains /
Families
for MAPKAP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAPKAP1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BPZ7ProtoNet protein and cluster: Q9BPZ7 1 Blocks protein family: IPB008828 Stress-activated map kinase interacting 1
UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7Similarity: Belongs to the SIN1 family |
Function
for MAPKAP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 isactivated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to functionupstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guaninenucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays acritical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop ofAKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required forcomplex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization andautophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 andATF2-mediated transcription
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAP1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAP1 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): MAPKAP1 (NM_001006620) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAPKAP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAP1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MAPKAP1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MAPKAP1:
Animal Models:
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Mapkap1):
MAPKAP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAPKAP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | PIP3 activates AKT signaling | | | 3 | Immune System | | | 4 | CD28 co-stimulation | | | 5 | Signaling by the B Cell Receptor (BCR) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6  BioSystems Pathways for MAPKAP1 (see all 6)
5/32 
Reactome Pathways for MAPKAP1 (see all 32)
MAPKAP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPKAP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/37 Interacting proteins for MAPKAP1 (Q9BPZ72, 3 ENSP000002659604) via UniProtKB, MINT, STRING, and/or I2D (see all 37)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006950 | response to stress |
IEA | -- | | GO:0007173 | epidermal growth factor receptor signaling pathway |
TAS | -- | | GO:0008150 | biological_process |
ND | -- | | GO:0008543 | fibroblast growth factor receptor signaling pathway |
TAS | -- | | GO:0031295 | T cell costimulation |
TAS | -- |
MAPKAP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAPKAP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MAPKAP1 for compounds About GeneDecksing
 Browse Tocris compounds for MAPKAP1
1 HMDB Compound for MAPKAP1 About this table
2 Novoseek chemical compound relationships for MAPKAP1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sin-1 |
87.9 |
32 |
17303383 (7), 18687895 (7), 15363842 (2) |
| rantes |
62.5 |
1 |
10940894 (1) |
Search CenterWatch for drugs/clinical trials and news about MAPKAP1 / SIN1
|
Transcripts
for MAPKAP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAPKAP1 gene (6 alternative transcripts): NM_001006617.1 NM_001006618.1 NM_001006619.1 NM_001006620.1 NM_001006621.1 NM_024117.3 Unigene Cluster for MAPKAP1: Mitogen-activated protein kinase associated protein 1 Hs.495138 [show with all ESTs]Unigene Representative Sequence: NM_00100661718/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000373511 ENST00000350766 ENST00000373503 ENST00000373498 ENST00000483937
ENST00000444226 ENST00000497932 ENST00000496658 ENST00000496063 ENST00000420643
ENST00000473837(uc010mxb.1) ENST00000394060(uc004bqa.3) ENST00000427078(uc010mxc.1)
ENST00000437973 ENST00000468896 ENST00000448439 ENST00000373496 ENST00000433483
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAP1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAP1 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): MAPKAP1 (NM_001006620) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAPKAP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAP1 |
Additional cDNA sequence: AK290060.1 AK295364.1 AK298841.1 AK309507.1 AK310361.1 AK316149.1 AL833042.1 AY425957.1 AY524429.1 AY524430.1 AY524431.1 AY524432.1 AY633624.1 AY633625.1 AY633626.1 BC002326.2 BC003044.1 BC035236.1 M37191.1 24 DOTS entries: DT.452044 DT.95263279 DT.97787260 DT.100823123 DT.92444889 DT.121146878 DT.100823130 DT.100823131 DT.121146949 DT.97862546 DT.100823129 DT.100823125 DT.101984665 DT.121146985 DT.99942775 DT.206813 DT.92444870 DT.95226049 DT.121146900 DT.121146914 DT.91747111 DT.92444866 DT.92444879 DT.100753399 24/478 AceView cDNA sequences (see all 478): BM745870 BM717650 BC035236 BF739907 CA312318 AW852183 CA445702 BI754253 BM915367 BQ635959 AI277355 AI289599 BM469959 AY524430 AW377520 BE280180 BC002326 BQ215660 BI523605 BI334265 BM800437 AY524431 BX096366 AA291156
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAP1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAPKAP1
|
Expression
for MAPKAP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAPKAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGATGAATT
About this image
See MAPKAP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAPKAP1
SOURCE GeneReport for Unigene cluster: Hs.495138
UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7Tissue specificity: Ubiquitously expressed, with highest levels in heart and skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including MAPKAP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPKAP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPKAP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPKAP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPKAP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAP1 |
Orthologs
for MAPKAP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAPKAP1 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for MAPKAP1 (if available)
TreeFam Gene Tree for MAPKAP1 (if available) |
Paralogs
for MAPKAP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MAPKAP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAPKAP1 (128199672 - 128449672 bp, first 250kb of MAPKAP1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAPKAP1: -- | 2 SABiosciences Cancer Mutation PCR Assays for MAPKAP1: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPKAP1 |
|
Disorders
/ Diseases
for MAPKAP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAPKAP1 for disorders About GeneDecksing
OMIM gene information: 610558
OMIM disorders: --
17  diseases for MAPKAP1: About MalaCardscoffin-lowry syndrome bronchiolitis obliterans organizing pneumonia bronchiolitis obliterans bronchiolitis
osteolysis renal cell carcinoma multiple myeloma polymyositis
rheumatoid arthritis myeloma hematopoiesis pneumonia
arthritis fibrosis carcinoma hepatitis
sepsis
1 disease from the University of Copenhagen DISEASES database for MAPKAP1:Coffin-Lowry syndrome 2 Novoseek disease relationships for MAPKAP1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
23.6 |
1 |
9042178 (1) |
| tumors |
0 |
1 |
9042178 (1) |
Human Genome Epidemiology (HuGE) Navigator: MAPKAP1 (8 documents)
Export disorders for MAPKAP1 gene to outside databases
|
Publications
for MAPKAP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAPKAP1 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with MAPKAP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene. (PubMed id 15363842)1, 2, 3, 9 Schroder W.... Sculley T. (2004)
- Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. (PubMed id 17303383)1, 2, 9 Schroder W.A.... Bushell G. (2007)
- Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation. (PubMed id 15988011)1, 2, 9 Cheng J.... Su B. (2005)
- Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway. (PubMed id 17054722)1, 2 Makino C.... Ishii S. (2006)
- SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. (PubMed id 16962653)1, 2 Jacinto E....Su B. (2006)
- Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. (PubMed id 17043309)1, 2 Yang Q....Guan K.L. (2006)
- mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. (PubMed id 16919458)1, 2 Frias M.A.... Sabatini D.M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. (PubMed id 1849280)1, 2 Colicelli J....Wigler M. (1991)
- A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress. (PubMed id 18687895)1, 9 Ghosh D....Roberts R.M. (2008)
|
External Searches for MAPKAP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAPKAP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAPKAP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAPKAP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAPKAP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MAPKAP1 gene:
Search GeneIP for patents involving MAPKAP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAPKAP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MAPKAP1 | | OriGene shRNA RFP for MAPKAP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPKAP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPKAP1 | | | OriGene Protein Over-expression Lysate for MAPKAP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAPKAP1 | | OriGene 3'-UTR Clone for MAPKAP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPKAP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAPKAP1 | | OriGene Custom Protein Services for MAPKAP1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAPKAP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPKAP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPKAP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPKAP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPKAP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPKAP1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MAPKAP1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MAPKAP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAP1 |
|  |  |  | | | | ThermoFisher Antibodies for MAPKAP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAP1 |
|
|
|
|
