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MAPKAP1 Gene

protein-coding   GIFtS: 63
GCID: GC09M128199

Mitogen-Activated Protein Kinase Associated Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Associated Protein 11 2     TORC2 Subunit MAPKAP12 3
MIP12 3 5     JC3102 5
SIN12 3 5     SIN1b2
Stress-Activated Protein Kinase-Interacting 11 2     SIN1g2
Mitogen-Activated Protein Kinase 2-Associated Protein 12 3     MEKK2-Interacting Protein 12
Stress-Activated Map Kinase-Interacting Protein 12 3     Ras Inhibitor MGC27452
mSIN12 3     Stress-Activated Map Kinase Interacting Protein 12
SAPK-Interacting Protein 12 3     Target Of Rapamycin Complex 2 Subunit MAPKAP12

External Ids:    HGNC: 187521   Entrez Gene: 791092   Ensembl: ENSG000001194877   OMIM: 6105585   UniProtKB: Q9BPZ73   

Export aliases for MAPKAP1 gene to outside databases

Previous GC identifers: GC09M119314 GC09M119846 GC09M121653 GC09M123576 GC09M125280 GC09M127239 GC09M097812


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPKAP1 Gene:
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase.
Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate
polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for MAPKAP1 Gene:
MAPKAP1 (mitogen-activated protein kinase associated protein 1) is a protein-coding gene. Diseases associated with MAPKAP1 include bronchiolitis obliterans organizing pneumonia, and coffin-lowry syndrome. GO annotations related to this gene include phosphatidylinositol-3,4-bisphosphate binding and phosphatidylinositol-4,5-bisphosphate binding.

UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7
Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is
activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to
function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type
guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.
mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the
activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the
phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within
mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by
preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic
stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia
length through its interaction with CCDC28B independently of mTORC2 complex

Gene Wiki entry for MAPKAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPKAP1 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAPKAP1 promoter sequence
   Search Chromatin IP Primers for MAPKAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPKAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q34.11

MAPKAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPKAP1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M128199:  view genomic region     (about GC identifiers)

Start:
128,199,672 bp from pter      End:
128,469,513 bp from pter
Size:
269,842 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7 (See protein sequence)
Recommended Name: Target of rapamycin complex 2 subunit MAPKAP1  
Size: 522 amino acids; 59123 Da
Subunit: All isoforms except isoform 4 can be incorporated into the mammalian target of rapamycin complex 2
(mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind
to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts with GTP-bound HRAS
and KRAS. Interacts with IFNAR2 and SGK1. Isoform 2 interacts with NBN. Isoform 1 interacts with CCDC28B
1 PDB 3D structure from and Proteopedia for MAPKAP1:
3VOQ (3D)    
Secondary accessions: A8K1Z5 B1AMA4 B7Z309 Q00426 Q5JSV5 Q5JSV6 Q5JSV9 Q658R0 Q699U1 Q699U2
Q699U3 Q699U4 Q6GVJ0 Q6GVJ1 Q6GVJ2
Alternative splicing: 6 isoforms:  Q9BPZ7-1   Q9BPZ7-2   Q9BPZ7-3   Q9BPZ7-4   Q9BPZ7-5   Q9BPZ7-6   (Not involved in a TORC2 complex)

Explore the universe of human proteins at neXtProt for MAPKAP1: NX_Q9BPZ7

Explore proteomics data for MAPKAP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAPKAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001006618.1  NP_001006619.1  NP_001006620.1  NP_001006621.1  NP_001006622.1  NP_077022.1  

    ENSEMBL proteins: 
     ENSP00000362610   ENSP00000362597   ENSP00000265961   ENSP00000362602   ENSP00000412485  
     ENSP00000418607   ENSP00000400182   ENSP00000377624   ENSP00000408359   ENSP00000417766  
     ENSP00000362595   ENSP00000390024   ENSP00000265960   ENSP00000377627   ENSP00000362596  
    Reactome Protein details: Q9BPZ7

    MAPKAP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MAPKAP1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAPKAP1
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    Novus Biologicals MAPKAP1 Proteins
    Novus Biologicals MAPKAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAPKAP1

    MAPKAP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPKAP1
    R&D Systems Antibodies for MAPKAP1 (Sin1/MAPKAP1)
    Cell Signaling Technology (CST) Antibodies for MAPKAP1  (Sin1)
    OriGene Antibodies for MAPKAP1
    OriGene Custom Antibody Services for MAPKAP1
    Novus Biologicals MAPKAP1 Antibodies
    Abcam antibodies for MAPKAP1
    Cloud-Clone Corp. Antibodies for MAPKAP1
    ThermoFisher Antibodies for MAPKAP1
    LSBio Antibodies in human, mouse, rat for MAPKAP1

    MAPKAP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAPKAP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAPKAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPKAP1
    Cloud-Clone Corp. CLIAs for MAPKAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008828 SIN1

    Graphical View of Domain Structure for InterPro Entry Q9BPZ7

    ProtoNet protein and cluster: Q9BPZ7

    1 Blocks protein domain: IPB008828 Stress-activated map kinase interacting 1

    UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7
    Similarity: Belongs to the SIN1 family


    MAPKAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIN1_HUMAN, Q9BPZ7
    Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is
    activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to
    function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type
    guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.
    mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the
    activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the
    phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within
    mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by
    preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic
    stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia
    length through its interaction with CCDC28B independently of mTORC2 complex

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IDA17303383
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA17303383
    GO:0016301kinase activity ----
    GO:0017016Ras GTPase binding IDA17303383
         
    MAPKAP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MAPKAP1:
     Decreased viability 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mapkap1):
     cellular  mortality/aging 

    MAPKAP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPKAP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPKAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPKAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPKAP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPKAP1:
    hsa-mir-375 (MIRT019887), hsa-mir-26b-5p (MIRT029925)

    Block miRNA regulation of human, mouse, rat MAPKAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPKAP1 (see all 28):
    hsa-miR-607 hsa-miR-16-2* hsa-miR-605 hsa-miR-132 hsa-miR-520a-5p hsa-miR-759 hsa-miR-1273d hsa-miR-214*
    SwitchGear 3'UTR luciferase reporter plasmidMAPKAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPKAP1
    Predesigned siRNA for gene silencing in human, mouse, rat MAPKAP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPKAP1

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPKAP1 (see all 34)
    OriGene ORF clones in mouse, rat for MAPKAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): MAPKAP1 (NM_001006620)
    Sino Biological Human cDNA Clone for MAPKAP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPKAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAP1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPKAP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPKAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIN1_HUMAN, Q9BPZ7: Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus5
    plasma membrane5
    cytosol4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005794Golgi apparatus IDA17303383
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA17303383
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    MAPKAP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPKAP1 About   (see all 15)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    2Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    3CD28 co-stimulation
    CD28 co-stimulation0.66
    Costimulation by the CD28 family0.44
    CD28 dependent PI3K/Akt signaling0.66
    4Downstream Signaling Events Of B Cell Receptor (BCR)
    Downstream Signaling Events Of B Cell Receptor (BCR)0.79
    Signaling by the B Cell Receptor (BCR)0.79
    5Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MAPKAP1
        PI3K / Akt Signaling

    Selected BioSystems Pathways for MAPKAP1 (see all 7)
        TOR signaling
    Interferon type I
    mTOR signaling pathway
    Class I PI3K signaling events mediated by Akt
    CXCR3-mediated signaling events


    3 Reactome Pathways for MAPKAP1
        Constitutive PI3K/AKT Signaling in Cancer
    PIP3 activates AKT signaling
    CD28 dependent PI3K/Akt signaling



    MAPKAP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MAPKAP1: 
              mTOR Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPKAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPKAP1 (Q9BPZ72, 3 ENSP000002659604) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RICTORQ6R3272, 3, ENSP000003499594MINT-7556061 MINT-6948596 MINT-7556024 MINT-8088269 MINT-8088291 MINT-6948610 MINT-7556076 MINT-8150419 I2D: score=4 STRING: ENSP00000349959
    MTORP423452, 3, ENSP000003545584MINT-7556061 MINT-6948596 MINT-7556024 MINT-8088269 MINT-8088291 MINT-6948610 MINT-7556076 MINT-8150419 I2D: score=4 STRING: ENSP00000354558
    RPTORQ8N1222, 3, ENSP000003072724MINT-7556024 MINT-8150419 I2D: score=1 STRING: ENSP00000307272
    CDC42EP1Q005872, 3, ENSP000002490144MINT-67645 I2D: score=6 STRING: ENSP00000249014
    SFNP319472, 3MINT-3975485 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0021762substantia nigra development IEP--
    GO:0031295T cell costimulation TAS--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--

    MAPKAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPKAP1 (SIN1)

    1 HMDB Compound for MAPKAP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for MAPKAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sin-1 87.9 32 17303383 (7), 18687895 (7), 15363842 (2)
    rantes 62.5 1 10940894 (1)



    MAPKAP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAPKAP1 gene (6 alternative transcripts): 
    NM_001006617.1  NM_001006618.1  NM_001006619.1  NM_001006620.1  NM_001006621.1  NM_024117.3  

    Unigene Cluster for MAPKAP1:

    Mitogen-activated protein kinase associated protein 1
    Hs.495138  [show with all ESTs]
    Unigene Representative Sequence: NM_001006617
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000373511 ENST00000373498 ENST00000350766 ENST00000373503 ENST00000483937
    ENST00000444226 ENST00000497932 ENST00000496658 ENST00000496063 ENST00000420643
    ENST00000473837(uc010mxb.1) ENST00000394060(uc004bqa.3) ENST00000427078(uc010mxc.1)
    ENST00000437973 ENST00000468896 ENST00000448439 ENST00000373496 ENST00000433483


    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAPKAP1 (see all 28):
    hsa-miR-607 hsa-miR-16-2* hsa-miR-605 hsa-miR-132 hsa-miR-520a-5p hsa-miR-759 hsa-miR-1273d hsa-miR-214*
    SwitchGear 3'UTR luciferase reporter plasmidMAPKAP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAPKAP1
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    GenScript: all cDNA clones in your preferred vector (see all 6): MAPKAP1 (NM_001006620)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPKAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPKAP1
    Primer
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    OriGene qPCR primer pairs and template standards for MAPKAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPKAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPKAP1
      QuantiTect SYBR Green Assays in human, mouse, rat MAPKAP1
      QuantiFast Probe-based Assays in human, mouse, rat MAPKAP1

    Additional mRNA sequence: 

    AK290060.1 AK295364.1 AK298841.1 AK309507.1 AK310361.1 AK316149.1 AL833042.1 AY425957.1 
    AY524429.1 AY524430.1 AY524431.1 AY524432.1 AY633624.1 AY633625.1 AY633626.1 BC002326.2 
    BC003044.1 BC035236.1 M37191.1 

    24 DOTS entries:

    DT.452044  DT.95263279  DT.97787260  DT.100823123  DT.92444889  DT.121146878  DT.100823130  DT.100823131 
    DT.121146949  DT.97862546  DT.100823129  DT.100823125  DT.101984665  DT.121146985  DT.99942775  DT.206813 
    DT.92444870  DT.95226049  DT.121146900  DT.121146914  DT.91747111  DT.92444866  DT.92444879  DT.100753399 

    Selected AceView cDNA sequences (see all 478):

    CA445702 AY524432 BU156975 BM800437 AA291156 BX096366 BF939919 BU630149 
    BM142305 CB988955 AW853074 CA312318 AI652937 BE257465 AI139264 AW014028 
    AY524431 AA832463 BM469959 BM915367 AA319137 AA419114 BQ639077 BC035236 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAP1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                                                
    SP2:                                                        -     -                                 
    SP3:                                                        -     -     -                           
    SP4:                                                  -     -     -                                 


    ECgene alternative splicing isoforms for MAPKAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPKAP1 expression in normal human tissues (normalized intensities)      MAPKAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGATGAATT
    MAPKAP1 Expression
    About this image


    MAPKAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    MAPKAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPKAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495138

    UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7
    Tissue specificity: Ubiquitously expressed, with highest levels in heart and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including MAPKAP1: 
              mTOR Signaling in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAPKAP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapkap11 , 5 mitogen-activated protein kinase associated protein more1, 5 92.46(n)1
    97.13(a)1
      2 (22.84 cM)5
    2277431  NM_177345.31  NP_796319.11 
     344067715 
    chicken
    (Gallus gallus)
    Aves MAPKAP11 mitogen-activated protein kinase associated protein more 82.76(n)
    89.85(a)
      395627  NM_204826.1  NP_990157.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPKAP16
    mitogen-activated protein kinase associated protei...
    83(a)
    1 ↔ 1
    GL343535.1(269412-450507)
    African clawed frog
    (Xenopus laevis)
    Amphibia mapkap1-prov2 mitogen-activated protein kinase associated protein more 77.76(n)    BC043789.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005371961 target of rapamycin complex 2 subunit MAPKAP1-like 74.81(n)
    82.88(a)
      100537196  XM_003198574.2  XP_003198622.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sin11 SAPK-interacting protein 1 44.78(n)
    34.34(a)
      36604  NM_137119.3  NP_610963.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sinh-16
    Protein SINH-1 (sinh-1) mRNA, complete cds
    19(a)
    1 ↔ 1
    II(12228319-12236575) WBGene00013261


    ENSEMBL Gene Tree for MAPKAP1 (if available)
    TreeFam Gene Tree for MAPKAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPKAP1 (see all 4871)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1137792701,2
    C,F--128199229(+) AGCCCG/ATGCCG 5 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1509310821,2
    --128199233(+) CGTGCC/TGGGGA 5 -- ds50010--------
    rs2020702941,2
    C--128199300(+) TAGGG-/GGGGGA 5 -- ds50010--------
    rs1407438931,2
    --128199510(+) GAGGGC/TCAGCC 5 -- ds50010--------
    rs605891841,2
    C,F--128199542(+) GGCCCC/TGGTGC 5 -- ds50012Minor allele frequency- T:0.08WA 120
    rs1808635511,2
    --128199591(+) TGCCAA/CCACCC 5 -- ds50010--------
    rs1162355741,2
    F--128199655(+) AAACTC/AAACAC 5 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1501624391,2
    C--128199716(+) TATCGA/CATATG 5 -- ut310--------
    rs1467640141,2
    C--128199797(+) TCAAAC/TACAGA 5 -- ut310--------
    rs1851554221,2
    --128199837(+) TGGGTA/GGGGGG 5 -- ut310--------

    HapMap Linkage Disequilibrium report for MAPKAP1 (128199672 - 128449672 bp, first 250kb of MAPKAP1)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MAPKAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665863CNV Deletion23128226
    esv2659060CNV Deletion23128226
    esv2662785CNV Deletion23128226
    nsv6714CNV Insertion18451855
    esv1597155CNV Insertion17803354
    nsv515979CNV Loss19592680
    nsv466560CNV Loss19166990
    nsv831722CNV Gain17160897
    nsv825077CNV Gain20364138

    Human Gene Mutation Database (HGMD): MAPKAP1
    2 Site Specific Mutation Identification with PCR Assays for MAPKAP1:
    Cosmic IdAA Change
    75362p.D376G
    71566p.R81T
    SeqTarget long-range PCR primers for resequencing MAPKAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPKAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610558    OMIM disorders: --

    20 diseases for MAPKAP1:    About MalaCards
    bronchiolitis obliterans organizing pneumonia    coffin-lowry syndrome    bronchiolitis obliterans    bronchiolitis
    nephrogenic systemic fibrosis    polymyositis    pneumonia    cleft lip
    sepsis    myeloma    multiple myeloma    parkinson's disease
    renal cell carcinoma    rheumatoid arthritis    arthritis    hypertension
    hepatocellular carcinoma    hepatitis    neuronitis    malaria

    1 disease from the University of Copenhagen DISEASES database for MAPKAP1:
    Coffin-Lowry syndrome

    MAPKAP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for MAPKAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 23.6 1 9042178 (1)
    tumors 0 1 9042178 (1)

    Genetic Association Database (GAD): MAPKAP1
    Human Genome Epidemiology (HuGE) Navigator: MAPKAP1 (8 documents)

    Export disorders for MAPKAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPKAP1 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with MAPKAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene. (PubMed id 15363842)1, 2, 3, 9 Schroder W.... Sculley T. (Gene 2004)
    2. Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. (PubMed id 17303383)1, 2, 9 Schroder W.A.... Bushell G. (Cell. Signal. 2007)
    3. Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation. (PubMed id 15988011)1, 2, 9 Cheng J.... Su B. (Mol. Cell. Biol. 2005)
    4. Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. (PubMed id 23762398)1, 2 Wang J.Q....Wu K.J. (PLoS ONE 2013)
    5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    6. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway. (PubMed id 17054722)1, 2 Makino C.... Ishii S. (Genes Cells 2006)
    10. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. (PubMed id 16962653)1, 2 Jacinto E.... Su B. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79109 HGNC: 18752 AceView: MAPKAP1 Ensembl:ENSG00000119487 euGenes: HUgn79109
    ECgene: MAPKAP1 H-InvDB: MAPKAP1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPKAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPKAP1 gene:
    Search GeneIP for patents involving MAPKAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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