Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK9 Gene

protein-coding   GIFtS: 75
GCID: GC05M179595

Mitogen-Activated Protein Kinase 9


(Previous symbol: PRKM9)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase 91 2     EC 2.7.11.243 8
PRKM91 2 3 5     JNK2A2
JNK22 3 5     JNK2ALPHA2
Jun Kinase1 2     JNK2B2
Stress-Activated Protein Kinase 1a2 3     JNK2BETA2
Stress-Activated Protein Kinase JNK22 3     SAPK2
JNK-552 3     C-Jun Kinase 22
SAPK1a2 3     p54a2
C-Jun N-Terminal Kinase 22 3     p54aSAPK2
MAP Kinase 92 3     SAPK1A3
MAPK 92 3     EC 2.7.118

External Ids:    HGNC: 68861   Entrez Gene: 56012   Ensembl: ENSG000000507487   OMIM: 6028965   UniProtKB: P459843   

Export aliases for MAPK9 gene to outside databases

Previous GC identifers: GC05M179777 GC05M180640 GC05M179772 GC05M174385


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPK9 Gene:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. This kinase targets specific transcription factors,
and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related
to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome
c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks
the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells.
Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively
spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Sep 2008)

GeneCards Summary for MAPK9 Gene: 
MAPK9 (mitogen-activated protein kinase 9) is a protein-coding gene. Diseases associated with MAPK9 include skin cancer, and acute liver failure, and among its related super-pathways are MAPK Cascade and RANK Signaling in Osteoclasts. GO annotations related to this gene include transcription factor binding and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is MAPK12.

UniProtKB/Swiss-Prot: MK09_HUMAN, P45984
Function: Serine/threonine-protein kinase involved in various processes such as cell proliferation,
differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as
proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal
kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7
phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors,
primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response
to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA
polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating
key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized
differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1,
BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic
stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation
and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons
Function: MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN,
whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation,
which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and
JUND binds only weakly to it

summary for MAPK9 Gene:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK9 (Mitogen-activated protein kinase 9) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK9 gene promoter:
         TBP   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPK9 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

MAPK9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK9 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M179595:  view genomic region     (about GC identifiers)

Start:
179,660,143 bp from pter      End:
179,719,099 bp from pter
Size:
58,957 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MK09_HUMAN, P45984 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 9  
Size: 424 amino acids; 48139 Da
Cofactor: Magnesium
Subunit: Interacts with MECOM and DCLK2 (By similarity). Binds to at least four scaffolding proteins,
MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other
components of the JNK signaling pathway. Interacts with NFATC4. Interacts with ATF7; the interaction does not
phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN. Interacts with BCL10.
Interacts with CTNNB1 and GSK3B
Subcellular location: Cytoplasm. Nucleus
2 PDB 3D structures from and Proteopedia for MAPK9:
3E7O (3D)        3NPC (3D)    
Secondary accessions: A8K0S3 B5BU66 B5M0B4 D3DWQ8 D3DWQ9 Q15708 Q15710 Q15711 Q8N5C5
Alternative splicing: 5 isoforms:  P45984-1   P45984-2   P45984-3   P45984-4   P45984-5   

Explore the universe of human proteins at neXtProt for MAPK9: NX_P45984

Explore proteomics data for MAPK9 at MOPED 

Post-translational modifications:

  • UniProtKB: Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated
    in vitro
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P45984

  • 4/27 DME Specific Peptides for MAPK9 (P45984) (see all 27)
     KELIYKE  ILDFGLA  LDFGLAR  LLSKMLV 

    MAPK9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAPK9 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001128516.1  NP_002743.3  NP_620707.1  NP_620708.1  NP_620709.1  

    ENSEMBL proteins: 
     ENSP00000394560   ENSP00000377028   ENSP00000389338   ENSP00000345524   ENSP00000321410  
     ENSP00000377029   ENSP00000397422   ENSP00000430608   ENSP00000443149   ENSP00000380262  
    Reactome Protein details: P45984
    Human Recombinant Protein Products for MAPK9: 
    EMD Millipore Purified and/or Recombinant MAPK9 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MAPK9
    OriGene Protein Over-expression Lysate for MAPK9
    OriGene MassSpec for MAPK9 
    OriGene Custom Protein Services for MAPK9
    GenScript Purified and Recombinant Proteins for MAPK9
    Novus Biologicals MAPK9 Proteins
    Novus Biologicals MAPK9 Lysates
    Sino Biological Recombinant Protein for MAPK9
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MAPK9
    Cloud-Clone Corp. Proteins for MAPK9 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    MAPK9 for ontologies           About GeneDecksing



    MAPK9 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK9
    R&D Systems Antibodies for MAPK9 (JNK2)
    Cell Signaling Technology (CST) Antibodies for MAPK9  (JNK2)
    OriGene Antibodies for MAPK9
    OriGene Custom Antibody Services for MAPK9
    GenScript Custom Superior Antibodies Services for MAPK9
    Novus Biologicals MAPK9 Antibodies
    Abcam antibodies for MAPK9
    Cloud-Clone Corp. Antibodies for MAPK9 
    ThermoFisher Antibody for MAPK9
    LSBio Antibodies in human, mouse, rat for MAPK9 

    Assay Products for MAPK9: 
    EMD Millipore Kits and Assays for the Analysis of MAPK9
    OriGene Custom Assay Services for MAPK9
    R&D Systems ELISAs for MAPK9 (JNK2)         (see all)
    GenScript Custom Assay Services for MAPK9
    Enzo Life Sciences assays for MAPK9
    Cloud-Clone Corp. ELISAs for MAPK9 
    Cloud-Clone Corp. CLIAs for MAPK9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 9 
    JNK subfamily
    Mitogen-activated protein kinases

    5/6 InterPro protein domains (see all 6):
     IPR008351 MAPK_JNK
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR003527 MAP_kinase_CS

    Graphical View of Domain Structure for InterPro Entry P45984

    ProtoNet protein and cluster: P45984

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008351 JNK MAP kinase signature


    UniProtKB/Swiss-Prot: MK09_HUMAN, P45984
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK09_HUMAN, P45984
    Function: Serine/threonine-protein kinase involved in various processes such as cell proliferation,
    differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as
    proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal
    kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7
    phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors,
    primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response
    to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA
    polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating
    key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized
    differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1,
    BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic
    stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation
    and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons
    Function: MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN,
    whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation,
    which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and
    JUND binds only weakly to it
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases,
    MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183
    preferentially. Inhibited by dual specificity phosphatases, such as DUSP1

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004672protein kinase activity ----
    GO:0004705JUN kinase activity IDA8654373
    GO:0004707MAP kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
         
    MAPK9 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAPK9:
     Increased cell death in breast  Increased mitotic index 

         15/20 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mapk9) (see all 20):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    MAPK9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mapk9tm1Flv for MAPK9

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAPK9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAPK9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK9 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPK9:
    hsa-mir-106b (MIRT005864), hsa-mir-20a (MIRT005856), hsa-mir-93 (MIRT003240), hsa-mir-17 (MIRT004359), hsa-mir-199a-3p (MIRT003982)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK9
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK9 (see all 61):
    hsa-let-7d hsa-miR-429 hsa-miR-106a hsa-miR-218-1* hsa-miR-138-2* hsa-miR-764 hsa-miR-29b-1* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidMAPK9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAPK9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK9
    Sirion Biotech Customized adenovirus for overexpression of MAPK9

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAPK9 (see all 30)
    OriGene ORF clones in mouse, rat for MAPK9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): MAPK9 (NM_002752)
    Sino Biological Human cDNA Clone for MAPK9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK9
    Sirion Biotech Customized lentivirus for stable overexpression of MAPK9 
                         Customized lentivirus expression plasmids for stable overexpression of MAPK9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK9
    Search LifeMap BioReagents cell lines for MAPK9
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAPK9 About   (see all 142)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1G-protein signaling Ras family GTPases in kinase cascades (scheme)
    G-protein signaling Ras family GTPases in kinase cascades (scheme)0.44
    Activation of the AP-1 family of transcription factors0.33
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Rapid glucocorticoid signaling0.31
    Oncostatin M Signaling Pathway0.37
    2BAFF in B-Cell Signaling
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANKL/RANK Signaling Pathway0.31
    RANK Signaling in Osteoclasts0.45
    3TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    Apoptosis through Death Receptors0.42
    Apoptotic Pathways Triggered By HIV10.42
    TWEAK Signaling Pathway0.31
    4Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    5Focal Adhesion
    Focal Adhesion0.64
    HGF Pathway0.34
    Focal adhesion0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/32 EMD Millipore Pathways for MAPK9 (see all 32)
        Apoptosis and survival FAS signaling cascades
    Immune response MIF in innate immunity response
    Cytoskeleton remodeling Keratin filaments
    Immune response IL-1 signaling pathway
    Signal transduction JNK pathway

    5/6 R&D Systems Pathways for MAPK9 (see all 6)
        NOD-like Receptor Signaling Pathways
    Wnt Signaling Pathway
    Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/108 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK9 (see all 108)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPK9
        MAP Kinase Signaling

    5 Tocris Bioscience Pathways for MAPK9
        Akt Pathway
    Insulin Pathway
    Toll-like Receptor Pathway
    VEGF Pathway
    MAPK Pathway

    5/33 GeneGo (Thomson Reuters) Pathways for MAPK9 (see all 33)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Development Endothelin-1/EDNRA signaling

    5/42 BioSystems Pathways for MAPK9 (see all 42)
        MAPK signaling pathway
    Focal Adhesion
    TGF Beta Signaling Pathway
    Wnt Signaling Pathway
    DNA damage response (only ATM dependent)

    5 Sino Biological Pathways for MAPK9 
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    p53 Pathway
    Death Receptor Signaling
    TGF-beta Signaling Pathway

    5/26        Reactome Pathways for MAPK9 (see all 26)
        FCERI mediated MAPK activation
    Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines

    1 PharmGKB Pathway for MAPK9
        VEGF Signaling Pathway

    5/37         Kegg Pathways  (Kegg details for MAPK9) (see all 37):
        MAPK signaling pathway
    ErbB signaling pathway
    Protein processing in endoplasmic reticulum
    Wnt signaling pathway
    Osteoclast differentiation


    MAPK9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/137 Interacting proteins for MAPK9 (P459841, 2, 3 ENSP000003214104) via UniProtKB, MINT, STRING, and/or I2D (see all 137)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K4P459852, 3, ENSP000002624454MINT-8259844 I2D: score=5 STRING: ENSP00000262445
    WDR62O433792, 3, ENSP000003847924MINT-68376 I2D: score=5 STRING: ENSP00000384792
    ACP5P136862, 3, ENSP000002187584MINT-64907 I2D: score=4 STRING: ENSP00000218758
    XPO7Q9UIA92, 3, ENSP000004048534MINT-64910 I2D: score=3 STRING: ENSP00000404853
    DUSP1P285622, 3, ENSP000002392234MINT-8217423 I2D: score=2 STRING: ENSP00000239223
    About this table

    Gene Ontology (GO): 5/52 biological process terms (GO ID links to tree view) (see all 52):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    MAPK9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK9 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK9:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for MAPK9

    Compounds for MAPK9 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS JNK 6oSelective JNK inhibitor[894804-07-0]
    SP 600125Novel and selective JNK inhibitor[129-56-6]
    TCS JNK 5aSelective inhibitor of JNK2 and JNK3[312917-14-9]
    SU 3327Selective JNK inhibitor[40045-50-9]
    BI 78D3 Selective, competitive JNK inhibitor [883065-90-5]

    3 HMDB Compounds for MAPK9    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for MAPK9    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide-- --target--10592235

    10/31 Novoseek inferred chemical compound relationships for MAPK9 gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp 600125 85 17 18565136 (1), 20200402 (1), 18336852 (1), 12898508 (1) (see all 14)
    pd 98,059 58.4 2 9837893 (1), 9731042 (1)
    helenalin 55.6 1 18336852 (1), 20167866 (1)
    olomoucine 46.1 1 9792443 (1)
    tyrosine 45.5 6 16619289 (2), 11775830 (1), 12393636 (1), 9501008 (1) (see all 5)
    threonine 43.2 1 10648385 (1)
    sb 203580 38.8 1 9731042 (1)
    n acetylcysteine 36.5 1 20188821 (1)
    wortmannin 32 2 16619289 (1), 16257269 (1)
    serine 28.4 2 15228592 (1), 10648385 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK9 / MK09

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAPK9 gene (5 alternative transcripts): 
    NM_001135044.1  NM_002752.4  NM_139068.2  NM_139069.2  NM_139070.2  

    Unigene Cluster for MAPK9:

    Mitogen-activated protein kinase 9
    Hs.484371  [show with all ESTs]
    Unigene Representative Sequence: NM_139069
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452135(uc003mls.4 uc003mlt.4) ENST00000393360(uc021yjk.1)
    ENST00000455781(uc010jlc.3 uc021yjj.1) ENST00000343111(uc003mlv.4)
    ENST00000347470 ENST00000520212 ENST00000393362 ENST00000524170 ENST00000425491(uc021yjl.1 uc011dgx.2)
    ENST00000523135 ENST00000523583 ENST00000539014 ENST00000397072(uc021yji.1)


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK9
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK9 (see all 61):
    hsa-let-7d hsa-miR-429 hsa-miR-106a hsa-miR-218-1* hsa-miR-138-2* hsa-miR-764 hsa-miR-29b-1* hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidMAPK9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAPK9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK9
    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK9 (see all 30)
    OriGene ORF clones in mouse, rat for MAPK9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): MAPK9 (NM_002752)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK9
    Sirion Biotech Customized lentivirus for stable overexpression of MAPK9 
                         Customized lentivirus expression plasmids for stable overexpression of MAPK9 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAPK9
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPK9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK9

    Additional mRNA sequence: 

    AB451302.1 AB451355.1 AB451433.1 AK289638.1 BC032539.1 CR536580.1 EU927388.1 HM036706.1 
    HM036707.1 HM036708.1 HM036709.1 L31951.1 U09759.1 U34821.1 U35002.1 U35003.1 

    13 DOTS entries:

    DT.447229  DT.75108965  DT.75119000  DT.95167728  DT.95167726  DT.95218885  DT.100023600  DT.91968163 
    DT.92430382  DT.40123550  DT.120848971  DT.121378762  DT.87015975 

    24/305 AceView cDNA sequences (see all 305):

    AW026710 AA857225 AI417833 BX643243 Z41496 BQ064649 AA862471 AI379420 
    BQ022913 AL525991 BI765324 AW771297 AI889961 CK300221 CA428635 BQ185526 
    CR536580 BX383056 AA468704 BU685854 U34821 BQ187463 AA449984 BM725392 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK9 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
    SP1:                    -                                   -           -                                                   
    SP2:                    -                                   -           -                                                   
    SP3:                    -                                         -     -                                                   
    SP4:                    -                                         -     -                                                   
    SP5:                                                        -                                                               


    ECgene alternative splicing isoforms for MAPK9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK9 expression in normal human tissues (normalized intensities)      MAPK9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACCACAAA
    MAPK9 Expression
    About this image


    MAPK9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             cerebellum   
     
     Liver (Hepatobiliary System)
             Hepatoblasts Liver Bud

    See MAPK9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK9

    SOURCE GeneReport for Unigene cluster: Hs.484371
        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK9 (see all 9): 
              Parkinson's Disease in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Insulin Resistance in human mouse rat
              Th1/Th2 Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAPK9
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPK9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK9 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk91 , 5 mitogen-activated protein kinase 91, 5 89.52(n)1
    96.93(a)1
      11 (29.96 cM)5
    264201  NM_001163671.11  NP_001157143.11 
     498467535 
    chicken
    (Gallus gallus)
    Aves MAPK91 mitogen-activated protein kinase 9 84.53(n)
    98.94(a)
      395983  NM_205095.1  NP_990426.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK96
    Uncharacterized protein
    97(a)
    1 ↔ 1
    2(141216262-141258529)
    zebrafish
    (Danio rerio)
    Actinopterygii mapk91 mitogen-activated protein kinase 9 73.33(n)
    85.78(a)
      100149273  XM_001919653.2  XP_001919688.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bsk3 JNK cascade protein serine/threonine
    kinase
    75(a)   2 31B3   --
    worm
    (Caenorhabditis elegans)
    Secernentea jnk-13 MAP kinase 69(a)
    (best of 5)
      IV(6957865-6963780)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HOG16
    Mitogen-activated protein kinase involved in osmor...
    33(a)
    1 → many
    XII(371620-372927)
    wheat
    (Triticum aestivum)
    Liliopsida BE444612.12   -- 70.65(n)    BE444612.1 


    ENSEMBL Gene Tree for MAPK9 (if available)
    TreeFam Gene Tree for MAPK9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK9 gene
    MAPK122  MAPK132  MAPK112  MAPK142  MAPK82  MAPK102  
    18/45 SIMAP similar genes for MAPK9 using alignment to 9 protein entries:     MK09_HUMAN (see all proteins) (see all similar genes):
    MAPK8    MAPK10    MAPK14    MAPK11    MAPK13    MAPK12
    MAPK4    TXK    DKFZp686O0215    MAPK7    DYRK4    MAPK3
    MAPK1    STK25    NLK    DKFZp686M02159    CDK7    STK11

    MAPK9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1341 SNPs in MAPK9 are shown (see all 1341)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0422604
    A colorectal adenocarcinoma sample4--see VAR_0422602 V M mis40--------
    VAR_0422614
    A head & Neck squamous cell carcinoma sample4--see VAR_0422612 K N mis40--------
    rs1139174651,2
    C,F--179665019(+) GTAATC/TCCACC 4 -- int11Minor allele frequency- T:0.50NA 2
    rs350818781,2
    C--179676518(+) TCATGCTCT/-  
            
    CTGTC
    5 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs675659711,2
    C--179676519(+) CATGC-/CTCT  
            
    TGTCA
    5 -- int10--------
    rs348646901,2
    C,F--179676520(-) CTGAC-/AG    
       
    /AGAG
    AGCAT
    5 -- int15NS 190
    rs345621451,2
    C,F--179677985(-) TACTC-/TTTTGA 5 -- int15Minor allele frequency- T:0.02NS 190
    rs347152821,2
    C,F--179680897(-) TGGGT-/GTCTCTT 5 -- int15Minor allele frequency- GT:0.47NS 190
    rs666226461,2
    C--179680963(+) TCTCT-/T/T   
       T
    /TTT
    TTTTT
    10 -- int1 cds10--------
    rs355329101,2
    C--179686034(+) GTTTC-/AAAAAA 5 -- int12Minor allele frequency- A:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for MAPK9 (179660143 - 179719099 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MAPK9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678619CNV Deletion23128226
    esv2731323CNV Deletion23290073
    nsv883290CNV Loss21882294
    nsv830563CNV Loss17160897
    nsv823363CNV Loss20364138
    nsv10787CNV Gain18304495
    dgv1881e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK9
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602896    OMIM disorders: --

    20/58 diseases for MAPK9 (see all 58):    About MalaCards
    skin cancer    acute liver failure    multiple endocrine neoplasia    essential thrombocythemia
    williams syndrome    shigellosis    trypanosomiasis    cystitis
    chagas disease    toxoplasmosis    sporadic breast cancer    endocarditis
    pheochromocytoma    acute promyelocytic leukemia    brain disease    pertussis
    non-small cell lung carcinoma    hyperglycemia    chronic myeloid leukemia    glioblastoma


    MAPK9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/21 Novoseek inferred disease relationships for MAPK9 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 38.5 5 12417721 (2), 12143039 (1), 8702671 (1), 12610149 (1)
    tumors 29.2 10 12417721 (2), 12538493 (1), 9162025 (1), 12143039 (1) (see all 9)
    glioma 24.1 2 17637567 (1), 14673001 (1)
    myeloid leukemia chronic 22.1 2 17949234 (2)
    glioblastoma 19.5 1 17047065 (1)
    pheochromocytoma 18.8 3 10470855 (1), 9589393 (1), 14673001 (1)
    multiple endocrine neoplasia 17.1 1 9393766 (1)
    cancer 13.9 3 15217928 (1), 11825878 (1), 12860462 (1)
    leukemia 9.55 1 8524841 (1)
    skin cancer 4.47 1 19204086 (1)

    Genetic Association Database (GAD): MAPK9
    Human Genome Epidemiology (HuGE) Navigator: MAPK9 (5 documents)

    Export disorders for MAPK9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK9 gene, integrated from 9 sources (see all 428):
    (articles sorted by number of sources associating them with MAPK9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. (PubMed id 8001819)1, 2, 3, 9 Kallunki T.... Karin M. (1994)
    2. The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. (PubMed id 17189706)1, 2, 9 Blonska M....Lin X. (2007)
    3. The crystal structure of JNK2 reveals conformational flexibility in the MAP kinase insert and indicates its involvement in the regulation of catalytic activity. (PubMed id 18801372)1, 2, 9 Shaw D....Kuglstatter A. (2008)
    4. Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. (PubMed id 15693750)1, 2, 9 Jagadish N.... Suri A. (2005)
    5. Role of the ATFa/JNK2 complex in Jun activation. (PubMed id 10376527)1, 2, 9 De Graeve F....Chatton B. (1999)
    6. Selective interaction of JNK protein kinase isoforms with transcription factors. (PubMed id 8654373)1, 2, 9 Gupta S....Davis R.J. (1996)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Molecular cloning and characterization of novel human JNK2 (MAPK9) transcript variants that show different stimulation activities on AP-1. (PubMed id 21110917)1, 2 Wang P....Ma D. (2010)
    9. JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. (PubMed id 21364637)1, 2 Tomlinson V....Basu S. (2010)
    10. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5601 HGNC: 6886 AceView: MAPK9 Ensembl:ENSG00000050748 euGenes: HUgn5601
    ECgene: MAPK9 Kegg: 5601 H-InvDB: MAPK9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK9 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mapk9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAPK9 gene:
    Search GeneIP for patents involving MAPK9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for MAPK9
     EMD Millipore Kits and Assays for the Analysis of MAPK9
     EMD Millipore Purified and/or Recombinant MAPK9 Protein
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK9
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for MAPK9 (JNK2)   Browse Cell Culture Products  
     ELISAs for MAPK9 (JNK2)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for MAPK9 (JNK2)  
     OriGene Antibodies for MAPK9   OriGene RNAi products in human, mouse, rat for MAPK9  
     OriGene qPCR primer pairs and template standards for MAPK9   OriGene Protein Over-expression Lysate for MAPK9  
     OriGene MassSpec something-or-other for MAPK9   OriGene clones in human, mouse for MAPK9  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAPK9   OriGene Purified Protein for MAPK9  
     OriGene ORF clones in mouse, rat for MAPK9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAPK9   OriGene Custom Protein Services for MAPK9  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAPK9
     QIAGEN SeqTarget long-range PCR primers for resequencing MAPK9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK9
     GenScript Purified and Recombinant Proteins for MAPK9 GenScript cDNA clones with any tag delivered in your preferred vector for MAPK9
     GenScript Custom Assay Services for MAPK9 GenScript Custom Superior Antibodies Services for MAPK9
     GenScript Custom overexpressing Cell Line Services for MAPK9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for MAPK9  (JNK2)

     Regulatory tfbs in MAPK9 promoter
     Search Chromatin IP Primers for MAPK9
     RT2 qPCR Primer Assay in human, mouse, rat MAPK9
     GNC Network for MAPK9
     SABiosciences PCR Arrays including human, mouse, rat MAPK9
     Tocris compounds for MAPK9
     Proteins and Antibodies for MAPK9
     Browse Sino Biological Cell Lysates
     cDNA Clones for MAPK9
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Drugs for MAPK9
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MAPK9 antibodies
     MAPK9 proteins
     MAPK9 lysates
     Antibodies for MAPK9
     See all of Abcam's Antibodies, Kits and Proteins for MAPK9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MAPK9




     Proteins for MAPK9
     Antibodies for MAPK9
     ELISAs for MAPK9
     CLIAs for MAPK9
     Search LifeMap BioReagents cell lines for MAPK9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK9
     SwitchGear 3'UTR luciferase reporter plasmids for MAPK9
     SwitchGear Promoter luciferase reporter plasmids for MAPK9
     ThermoFisher Antibody for MAPK9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK9
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MAPK9
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAPK9
    Customized:
     lentivirus for stable overexpression of MAPK9
     lentivirus expression plasmids for stable overexpression of MAPK9
     adenovirus for overexpression of MAPK9
     LSBio Antibodies in human, mouse, rat for MAPK9
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAPK9 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4