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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK8IP3 Gene

protein-coding   GIFtS: 57
GCID: GC16P001756

mitogen-activated protein kinase 8 interacting protein 3
 Explore 3 diseases affiliated with
MAPK8IP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAPK8IP3    

Aliases
for MAPK8IP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase 8 Interacting Protein 31 2     JNK-Interacting Protein 32 3
JIP31 2 3     SYD22
JSAP11 2     C-Jun-Amino-Terminal Kinase Interacting Protein 32
Syd1     C-Jun-Amino-Terminal Kinase-Interacting Protein 32
KIAA10661 3     Homolog Of Drosophila Sunday Driver 22
Mitogen-Activated Protein Kinase 8-Interacting Protein 32 3     JNK/SAPK-Associated Protein-12
JIP-32 3     JNK/Stress-Activated Protein Kinase-Associated Protein 12
JNK MAP Kinase Scaffold Protein 32 3     

External Ids:    HGNC: 68841   Entrez Gene: 231622   Ensembl: ENSG000001388347   OMIM: 6054315   UniProtKB: Q9UPT63   

Export aliases for MAPK8IP3 gene to outside databases

Previous GC identifers: GC16P001773 GC16P001696


Summaries
for MAPK8IP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPK8IP3:
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional
interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may
interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function
as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle
transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript
variants of this gene have been described, but the full-length nature of some of these variants has not been
determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: JIP3_HUMAN, Q9UPT6
Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a
regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By
similarity)

Gene Wiki entry for MAPK8IP3


Genomic Views
for MAPK8IP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK8IP3 gene promoter:
         HEN1   Nkx2-2   ZIC2/Zic2   Nkx2-5   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAPK8IP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK8IP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK8IP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

MAPK8IP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK8IP3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P001756:  view genomic region     (about GC identifiers)

Start:
 1,756,184 bp from pter      End:
 1,820,318 bp from pter
Size:
 64,135 bases      Orientation:
 plus strand

Proteins
for MAPK8IP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: JIP3_HUMAN, Q9UPT6 (See protein sequence)
Recommended Name: C-Jun-amino-terminal kinase-interacting protein 3  
Size: 1336 amino acids; 147457 Da
Subunit: Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal of
MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8/JNK1, MAPK9/JNK2 and
MAPK10/JNK3 to the N-terminal region, MAP2K4/MKK4 and MAP2K7/MKK7 to the central region and MAP3K11 to the C-terminal
region. Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding
complexes are then transported as a cargo of kinesin, to the required subcellular location (By similarity). Interacts
with ROCK1 and this interaction is enhanced by ultraviolet-B (UVB) radiation
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAK61290.1; Type=Erroneous gene model prediction; Sequence=BAA83018.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=BAB15727.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened; Sequence=CAB72318.1; Type=Erroneous gene model prediction;
Secondary accessions: A2A2B3 A7E2B3 Q96RY4 Q9H4I4 Q9H7P1 Q9NUG0
Alternative splicing: 2 isoforms:  Q9UPT6-1   Q9UPT6-2   

Explore the universe of human proteins at neXtProt for MAPK8IP3: NX_Q9UPT6

Post-translational modifications:

  • Phosphorylation by ROCK1 is crucial for the recruitment of JNK1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UPT6

    • MAPK8IP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035529.1  NP_055948.2  

    ENSEMBL proteins: 
     ENSP00000250894   ENSP00000348290   ENSP00000454739  

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    Uscn Proteins for MAPK8IP3

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ISS--
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm ----
    GO:0005790smooth endoplasmic reticulum IEA--
    GO:0005886plasma membrane ----


    MAPK8IP3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MAPK8IP3

    Protein Domains /
    Families
    for MAPK8IP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPK8IP3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR019143 JNK/Rab-associated_protein-1_N
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UPT6

    ProtoNet protein and cluster: Q9UPT6

    UniProtKB/Swiss-Prot: JIP3_HUMAN, Q9UPT6
    Similarity: Belongs to the JIP scaffold family


    Function
    for MAPK8IP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: JIP3_HUMAN, Q9UPT6
    Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
    aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a
    regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By
    similarity)

    miRNA
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    hsa-miR-128 hsa-miR-218 hsa-miR-650 hsa-miR-4314 hsa-miR-3150b-3p hsa-miR-556-3p hsa-miR-4293 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK8IP3 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: MAPK8IP3
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005078MAP-kinase scaffold activity ISS--
    GO:0005515protein binding ----
    GO:0008432JUN kinase binding IEA--
    GO:0019894kinesin binding ISS--
    GO:0019901protein kinase binding ISS--


    MAPK8IP3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MAPK8IP3:
     Decreased viability 

    Animal Models:
         Mouse knock-outs for MAPK8IP3: Mapk8ip3tm1Rjd Mapk8ip3tm1.1Ysok Mapk8ip3tm1Plhn
         8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Mapk8ip3):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  nervous system 
     normal  respiratory system  vision/eye 

    MAPK8IP3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPK8IP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    2Reelin Pathway (Cajal-Retzius cells)
    		Reelin Pathway (Cajal-Retzius cells)1.00
    3Signaling events mediated by focal adhesion kinase
    		Signaling events mediated by focal adhesion kinase1.00
    4Arf6 trafficking events
    		Arf6 trafficking events1.00
    5Rho Family GTPases
    		MAPK Signaling0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK8IP3
        MAPK Signaling
    Reelin Pathway (Cajal-Retzius cells)
    JNK Pathway

    3 BioSystems Pathways for MAPK8IP3 
        MAPK signaling pathway
    Arf6 trafficking events
    Signaling events mediated by focal adhesion kinase


    1         Kegg Pathway  (Kegg details for MAPK8IP3):
        MAPK signaling pathway


    MAPK8IP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK8IP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for MAPK8IP3 (Q9UPT62, 3 ENSP000002508944) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL4DP497032, 3MINT-63796 I2D: score=5 
    RIC8AQ9NPQ82, 3MINT-65787 I2D: score=5 
    MAPK9P459843, ENSP000003214104I2D: score=6 STRING: ENSP00000321410
    MAPK10P537793, ENSP000003521574I2D: score=5 STRING: ENSP00000352157
    MAPK8IP2Q133873, ENSP000003305724I2D: score=5 STRING: ENSP00000330572
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0007254JNK cascade ----
    GO:0007257activation of JUN kinase activity IEA--
    GO:0007411axon guidance IEA--
    GO:0007585respiratory gaseous exchange IEA--


    MAPK8IP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPK8IP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK8IP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MAPK8IP3
    1 Novoseek chemical compound relationship for MAPK8IP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 0 5 15911620 (3), 17029735 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK8IP3 / JIP3 

    Transcripts
    for MAPK8IP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPK8IP3 gene (2 alternative transcripts): 
    NM_001040439.1  NM_015133.3  

    Unigene Cluster for MAPK8IP3:

    Mitogen-activated protein kinase 8 interacting protein 3
    Hs.207763  [show with all ESTs]
    Unigene Representative Sequence: NM_015133
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250894(uc002cmk.3 uc002cml.3 uc021tah.1 uc010uvl.2)
    ENST00000356010 ENST00000564098(uc002cmi.1 uc002cmj.1) ENST00000561765
    ENST00000568271 ENST00000568774 ENST00000567849 ENST00000566589 ENST00000570131
    ENST00000561949 ENST00000567352 ENST00000562042 ENST00000564868 ENST00000566064
    ENST00000563868

    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK8IP3 (see all 39):
    hsa-miR-128 hsa-miR-218 hsa-miR-650 hsa-miR-4314 hsa-miR-3150b-3p hsa-miR-556-3p hsa-miR-4293 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK8IP3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK8IP3 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK8IP3
    Clone
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    Additional cDNA sequence: 

    AB028989.2 AB621811.1 AK024437.1 BC087861.1 BC137123.1 BC137124.1 BC144486.1 BC150266.1 
    CR749696.1 

    19 DOTS entries:

    DT.210921  DT.100782593  DT.95305108  DT.40198683  DT.100782588  DT.120722427  DT.100782591  DT.120722516 
    DT.99992086  DT.102844178  DT.95113577  DT.100742615  DT.100782587  DT.120722451  DT.120722515  DT.40229965 
    DT.75121383  DT.120722435  DT.120722445 

    24/207 AceView cDNA sequences (see all 207):

    BM791368 BM920459 CA425168 BE465709 CD365632 BQ639864 AK024437 BM013485 
    BX395549 BM694998 BF000537 NM_015133 CR624644 AI672597 BI767677 BM854594 
    Z41843 AW135253 CR749696 BQ706804 BM313084 AI921110 BQ083050 BQ024640 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8IP3 (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                                                                                -                             -                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                          -                                                                                                   
    SP4:                                                                                                                              
    SP5:                                                                                            -                                 


    ECgene alternative splicing isoforms for MAPK8IP3

    Expression
    for MAPK8IP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK8IP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGCAGGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPK8IP3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAPK8IP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK8IP3

    SOURCE GeneReport for Unigene cluster: Hs.207763
        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK8IP3: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    Orthologs
    for MAPK8IP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAPK8IP3 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAPK8IP31 mitogen-activated protein kinase 8 interacting protein more 80.26(n)
    88.61(a)    		   426986  XM_424591.3  XP_424591.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPK8IP36
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343649.1(177844-263715)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.140222 Xenopus laevis transcribed sequence with moderate similarity more 78.41(n)    CD329192.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mapk8ip31 mitogen-activated protein kinase 8 interacting protein more 70.82(n)
    74.17(a)    		   100318355  XM_002661119.1  XP_002661165.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta syd3 axon cargo transport kinesin binding 46(a)   66A20   --
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-163 Coiled coil protein 31(a)   III(9618429-9627831)   --


    ENSEMBL Gene Tree for MAPK8IP3 (if available)
    TreeFam Gene Tree for MAPK8IP3 (if available) 

    Paralogs
    for MAPK8IP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK8IP3 gene
    ECT22  ARHGEF102  SPAG92  ARHGEF172  ARHGEF10L2  
    3 SIMAP similar genes for MAPK8IP3 using alignment to 5 protein entries:     JIP3_HUMAN (see all proteins):
    DKFZp762N1113    HLC4    SPAG9

    MAPK8IP3 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPK8IP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1177 NCBI SNPs in MAPK8IP3 are shown (see all 1177)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1119349051,2
    		C,--1712946(+) TGACCG/ATCCGT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1437380961,2
    		--1754221(+) ATAGAG/TCCTGG 2 -- us2k10--------
    rs1419804631,2
    		--1754548(+) TGTTTC/TGGTGC 2 -- us2k10--------
    rs1473216001,2
    		--1754950(+) GAAGTA/GTAAGA 2 -- us2k10--------
    rs286898491,2
    		C--1755334(+) ACCCAC/GTGGAT 2 -- us2k10--------
    rs1390857901,2
    		--1755368(+) TGAAAA/GGTAAC 2 -- us2k10--------
    rs80578181,2
    		C,F,A,--1755416(+) tcccaA/Gcactc 2 -- us2k15Minor allele frequency- G:0.44NA CSA 9
    rs1875046481,2
    		--1755547(+) CGGAGA/GCTGAG 2 -- us2k10--------
    rs1925202861,2
    		--1755661(+) AAAAAA/GAAAAA 2 -- us2k10--------
    rs727611581,2
    		--1755667(+) AAAAAA/GAAAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPK8IP3 (1756184 - 1820318 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for MAPK8IP3
         7 CNVs: 49667 72420 49665 29999 5329 49668 49666

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    Disorders / Diseases
    for MAPK8IP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPK8IP3 for disorders           About GeneDecksing

    OMIM gene information: 605431    OMIM disorders: --

    3 diseases for MAPK8IP3:    About MalaCards
    fibrous histiocytoma    neuronitis    histiocytoma

    1 disease from the University of Copenhagen DISEASES database for MAPK8IP3:
    Fibrous histiocytoma

    Export disorders for MAPK8IP3 gene to outside databases

    Publications
    for MAPK8IP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK8IP3 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with MAPK8IP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. (PubMed id 19036714)1, 2 Ongusaha P.P....Lee S.W. (2008)
    2. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    3. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. (PubMed id 12189133)1, 2 Matsuura H....Ichijo H. (2002)
    4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
    5. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. (PubMed id 10629060)1, 3 Kelkar N....Davis R.J. (2000)
    6. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (2000)
    7. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    8. JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. (PubMed id 10523642)1, 3 Ito M....Yamamoto K.I. (1999)
    9. JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration. (PubMed id 16141199)1, 9 Takino T....Sato H. (2005)
    10. A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways. (PubMed id 11044439)1, 9 Kuboki Y....Yoshioka K. (2000)

    External Searches for MAPK8IP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAPK8IP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23162 HGNC: 6884 AceView: MAPK8IP3 Ensembl:ENSG00000138834 euGenes: HUgn23162
    ECgene: MAPK8IP3 Kegg: 23162 H-InvDB: MAPK8IP3

    Other Databases showing MAPK8IP3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1066

    Specialized Databases showing MAPK8IP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK8IP3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAPK8IP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPK8IP3 gene:
    Search GeneIP for patents involving MAPK8IP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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