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MAPK8IP3 Gene

protein-coding   GIFtS: 60
GCID: GC16P001756

Mitogen-Activated Protein Kinase 8 Interacting Protein 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 8 Interacting Protein 31 2     SYD22
Homolog Of Drosophila Sunday Driver 21 2     C-Jun-Amino-Terminal Kinase Interacting Protein 32
Mitogen-Activated Protein Kinase 8-Interacting Protein 32 3     C-Jun-Amino-Terminal Kinase-Interacting Protein 32
JIP-32 3     JNK/SAPK-Associated Protein-12
JIP32 3     JNK/Stress-Activated Protein Kinase-Associated Protein 12
JNK MAP Kinase Scaffold Protein 32 3     syd2
JNK-Interacting Protein 32 3     KIAA10663
JSAP12     

External Ids:    HGNC: 68841   Entrez Gene: 231622   Ensembl: ENSG000001388347   OMIM: 6054315   UniProtKB: Q9UPT63   

Export aliases for MAPK8IP3 gene to outside databases

Previous GC identifers: GC16P001773 GC16P001696


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK8IP3 Gene:
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the
functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this
protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway,
and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to
regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several
alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of
these variants has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPK8IP3 Gene:
MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3) is a protein-coding gene. GO annotations related to this gene include protein kinase binding and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is SPAG9.

UniProtKB/Swiss-Prot: JIP3_HUMAN, Q9UPT6
Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a
regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By
similarity)

Gene Wiki entry for MAPK8IP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK8IP3 gene promoter:
         HEN1   Nkx2-2   ZIC2/Zic2   Nkx2-5   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPK8IP3 promoter sequence
   Search Chromatin IP Primers for MAPK8IP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK8IP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

MAPK8IP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK8IP3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P001756:  view genomic region     (about GC identifiers)

Start:
1,756,184 bp from pter      End:
1,820,318 bp from pter
Size:
64,135 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JIP3_HUMAN, Q9UPT6 (See protein sequence)
Recommended Name: C-Jun-amino-terminal kinase-interacting protein 3  
Size: 1336 amino acids; 147457 Da
Subunit: Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal
of MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8/JNK1,
MAPK9/JNK2 and MAPK10/JNK3 to the N-terminal region, MAP2K4/MKK4 and MAP2K7/MKK7 to the central region and
MAP3K11 to the C-terminal region. Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1.
Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required
subcellular location (By similarity). Interacts with ROCK1 and this interaction is enhanced by ultraviolet-B
(UVB) radiation
Sequence caution: Sequence=AAK61290.1; Type=Erroneous gene model prediction; Sequence=BAA83018.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=BAB15727.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=CAB72318.1; Type=Erroneous gene model prediction;
Secondary accessions: A2A2B3 A7E2B3 Q96RY4 Q9H4I4 Q9H7P1 Q9NUG0
Alternative splicing: 2 isoforms:  Q9UPT6-1   Q9UPT6-2   

Explore the universe of human proteins at neXtProt for MAPK8IP3: NX_Q9UPT6

Explore proteomics data for MAPK8IP3 at MOPED

Post-translational modifications: 

  • Phosphorylation by ROCK1 is crucial for the recruitment of JNK1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAPK8IP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035529.1  NP_055948.2  

    ENSEMBL proteins: 
     ENSP00000250894   ENSP00000348290   ENSP00000454739  

    MAPK8IP3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR019143 JNK/Rab-associated_protein-1_N
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UPT6

    ProtoNet protein and cluster: Q9UPT6

    UniProtKB/Swiss-Prot: JIP3_HUMAN, Q9UPT6
    Similarity: Belongs to the JIP scaffold family


    Find genes that share domains with MAPK8IP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JIP3_HUMAN, Q9UPT6
    Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
    aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a
    regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005078MAP-kinase scaffold activity ISS--
    GO:0005515protein binding ----
    GO:0008432JUN kinase binding IEA--
    GO:0019894kinesin binding ISS--
    GO:0019901protein kinase binding ISS--
         
    Find genes that share ontologies with MAPK8IP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MAPK8IP3:
     Decreased viability 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mapk8ip3):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  nervous system 
     normal  respiratory system  vision/eye 

    Find genes that share phenotypes with MAPK8IP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MAPK8IP3: Mapk8ip3tm1Rjd Mapk8ip3tm1.1Ysok Mapk8ip3tm1Plhn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK8IP3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK8IP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK8IP3

    miRNA
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    miRTarBase miRNAs that target MAPK8IP3:
    hsa-mir-320a (MIRT044821)

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    Selected qRT-PCR Assays for microRNAs that regulate MAPK8IP3 (see all 39):
    hsa-miR-128 hsa-miR-218 hsa-miR-650 hsa-miR-4314 hsa-miR-3150b-3p hsa-miR-556-3p hsa-miR-4293 hsa-miR-3612
    SwitchGear 3'UTR luciferase reporter plasmidMAPK8IP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAPK8IP3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JIP3_HUMAN, Q9UPT6: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    cytosol3
    nucleus3
    endoplasmic reticulum2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ISS--
    GO:0005737cytoplasm ----
    GO:0005790smooth endoplasmic reticulum IEA--
    GO:0005886plasma membrane ----
    GO:0030425dendrite IEA--

    Find genes that share ontologies with MAPK8IP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK8IP3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2ERK Signaling
    MAPK Signaling0.58
    3TGF-Beta Pathway
    JNK Pathway0.51
    4Signaling events mediated by focal adhesion kinase
    Signaling events mediated by focal adhesion kinase
    5Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)


    Find genes that share SuperPaths with MAPK8IP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK8IP3
        MAPK Signaling
    Reelin Pathway (Cajal-Retzius cells)
    JNK Pathway

    3 BioSystems Pathways for MAPK8IP3
        MAPK signaling pathway
    Arf6 trafficking events
    Signaling events mediated by focal adhesion kinase


    1 Kegg Pathway  (Kegg details for MAPK8IP3):
        MAPK signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK8IP3: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK8IP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK8IP3 (Q9UPT62, 3 ENSP000002508944) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL4DP497032, 3MINT-63796 I2D: score=5 
    RIC8AQ9NPQ82, 3MINT-65787 I2D: score=5 
    MAPK9P459843, ENSP000003214104I2D: score=6 STRING: ENSP00000321410
    MAPK10P537793, ENSP000003521574I2D: score=5 STRING: ENSP00000352157
    MAPK8IP2Q133873, ENSP000003305724I2D: score=5 STRING: ENSP00000330572
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0007254JNK cascade ----
    GO:0007257activation of JUN kinase activity IEA--
    GO:0007411axon guidance IEA--
    GO:0007585respiratory gaseous exchange IEA--

    Find genes that share ontologies with MAPK8IP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    6 ApexBio Compounds for MAPK8IP3     About this table
    CompoundAction CAS #
    AS 602801novel, orally active, Jun Kinase Inhibitor[848344-36-5]
    CC-401 hydrochloridesecond generation ATP-competitive anthrapyrazolone JNK inhibitor[1438391-30-0]
    CC-930selective JNK inhibitor[899805-25-5]
    JNK-IN-7relatively selective JNK inhibitor[1408064-71-0]
    JNK-IN-8highly selective JNK inhibitor[1410880-22-6]
    SP 600125Selective, reversible, and ATP-competitive JNK1/2/3 inhibitor[129-56-6]

    Browse Tocris compounds for MAPK8IP3 (JIP3)

    1 Novoseek inferred chemical compound relationship for MAPK8IP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 0 5 15911620 (3), 17029735 (1)



    Find genes that share compounds with MAPK8IP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAPK8IP3 gene (2 alternative transcripts): 
    NM_001040439.1  NM_015133.3  

    Unigene Cluster for MAPK8IP3:

    Mitogen-activated protein kinase 8 interacting protein 3
    Hs.207763  [show with all ESTs]
    Unigene Representative Sequence: NM_015133
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250894(uc002cmk.3 uc002cml.3 uc021tah.1 uc010uvl.2)
    ENST00000356010 ENST00000564098(uc002cmi.1 uc002cmj.1) ENST00000561765
    ENST00000568271 ENST00000568774 ENST00000567849 ENST00000566589 ENST00000570131
    ENST00000561949 ENST00000567352 ENST00000562042 ENST00000564868 ENST00000566064
    ENST00000563868
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    hsa-miR-128 hsa-miR-218 hsa-miR-650 hsa-miR-4314 hsa-miR-3150b-3p hsa-miR-556-3p hsa-miR-4293 hsa-miR-3612
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    Additional mRNA sequence: 

    AB028989.2 AB621811.1 AK024437.1 BC087861.1 BC137123.1 BC137124.1 BC144486.1 BC150266.1 
    CR749696.1 

    19 DOTS entries:

    DT.210921  DT.100782593  DT.95305108  DT.40198683  DT.100782588  DT.120722427  DT.100782591  DT.120722516 
    DT.99992086  DT.102844178  DT.95113577  DT.100742615  DT.100782587  DT.120722451  DT.120722515  DT.40229965 
    DT.75121383  DT.120722435  DT.120722445 

    Selected AceView cDNA sequences (see all 207):

    BI042761 BI767677 BM803227 AK024437 Z41843 BM791368 BF000537 CD365632 
    BM920459 BX395549 BM854594 AA504284 AI921110 BQ639864 BQ083050 BE465709 
    AW135253 BM013485 CR624644 CA425168 AI672597 CR749696 BM313084 BQ706804 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8IP3 (see all 18)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                                                                                -                             -                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                          -                                                                                                   
    SP4:                                                                                                                              
    SP5:                                                                                            -                                 


    ECgene alternative splicing isoforms for MAPK8IP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPK8IP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGCAGGCT
    MAPK8IP3 Expression
    About this image


    MAPK8IP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    MAPK8IP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK8IP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.207763
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK8IP3: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAPK8IP3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk8ip31 , 5 mitogen-activated protein kinase 8 interacting protein more1, 5 86.38(n)1
    93.79(a)1
      17 (12.53 cM)5
    309571  NM_013931.41  NP_038959.21 
     248921535 
    chicken
    (Gallus gallus)
    Aves MAPK8IP31 mitogen-activated protein kinase 8 interacting protein more 80.26(n)
    88.61(a)
      426986  XM_424591.4  XP_424591.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK8IP36
    mitogen-activated protein kinase 8 interacting pro...
    85(a)
    1 ↔ 1
    GL343649.1(177805-263715)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.140222 Xenopus laevis transcribed sequence with moderate similarity more 78.41(n)    CD329192.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapk8ip31 mitogen-activated protein kinase 8 interacting protein more 70.78(n)
    74.18(a)
      100318355  XM_002661119.2  XP_002661165.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta syd3 axon cargo transport kinesin binding 46(a)   66A20   --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-163 Coiled coil protein 31(a)   III(9618429-9627831)   --


    ENSEMBL Gene Tree for MAPK8IP3 (if available)
    TreeFam Gene Tree for MAPK8IP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK8IP3 gene
    SPAG92  ARHGEF102  ARHGEF172  ARHGEF10L2  
    3 SIMAP similar genes for MAPK8IP3 using alignment to 5 protein entries:     JIP3_HUMAN (see all proteins):
    DKFZp762N1113    HLC4    SPAG9

    Find genes that share paralogs with MAPK8IP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPK8IP3 (see all 1676)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437380961,2
    --1754221(+) ATAGAG/TCCTGG 2 -- us2k10--------
    rs1419804631,2
    C--1754548(+) TGTTTC/TGGTGC 2 -- us2k10--------
    rs1473216001,2
    --1754950(+) GAAGTA/GTAAGA 2 -- us2k10--------
    rs347608751,2
    C--1755300(+) AAAAA-/A/AA  
            
    TCGGT
    2 -- us2k11CSA 2
    rs286898491,2
    C--1755334(+) ACCCAC/GTGGAT 2 -- us2k10--------
    rs1390857901,2
    --1755368(+) TGAAAA/GGTAAC 2 -- us2k10--------
    rs80578181,2
    C,F,A--1755416(+) tcccaA/Gcactc 2 -- us2k15Minor allele frequency- G:0.44NA CSA 9
    rs1875046481,2
    --1755547(+) CGGAGA/GCTGAG 2 -- us2k10--------
    rs1925202861,2
    --1755661(+) AAAAAA/GAAAAA 2 -- us2k10--------
    rs727611581,2
    --1755667(+) AAAAAA/GAAAAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPK8IP3 (1756184 - 1820318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAPK8IP3 (see all 42):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750357CNV Deletion23290073
    esv2750367CNV Deletion23290073
    esv2750360CNV Deletion23290073
    esv2750358CNV Deletion23290073
    esv2750365CNV Deletion23290073
    esv2750361CNV Deletion23290073
    esv2750353CNV Deletion23290073
    esv2750355CNV Deletion23290073
    esv2750350CNV Deletion23290073
    esv2667640CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605431    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for MAPK8IP3:
    Fibrous histiocytoma

    Find genes that share disorders with MAPK8IP3           About GenesLikeMe


    Export disorders for MAPK8IP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK8IP3 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with MAPK8IP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. (PubMed id 19036714)1, 2 Ongusaha P.P.... Lee S.W. (Sci. Signal. 2008)
    2. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    3. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1- JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. (PubMed id 12189133)1, 2 Matsuura H.... Ichijo H. (J. Biol. Chem. 2002)
    4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    5. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. (PubMed id 10629060)1, 3 Kelkar N....Davis R.J. (Mol. Cell. Biol. 2000)
    6. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (DNA Res. 2000)
    7. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    8. JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. (PubMed id 10523642)1, 3 Ito M....Yamamoto K.I. (Mol. Cell. Biol. 1999)
    9. JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration. (PubMed id 16141199)1, 9 Takino T....Sato H. (J. Biol. Chem. 2005)
    10. A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways. (PubMed id 11044439)1, 9 Kuboki Y....Yoshioka K. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23162 HGNC: 6884 AceView: MAPK8IP3 Ensembl:ENSG00000138834 euGenes: HUgn23162
    ECgene: MAPK8IP3 Kegg: 23162 H-InvDB: MAPK8IP3

    (According to HUGE)
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    HUGE: KIAA1066

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPK8IP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPK8IP3 gene:
    Search GeneIP for patents involving MAPK8IP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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