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Aliases for MAPK8IP3 Gene

Aliases for MAPK8IP3 Gene

  • Mitogen-Activated Protein Kinase 8 Interacting Protein 3 2 3 5
  • Homolog Of Drosophila Sunday Driver 2 2 3
  • JNK MAP Kinase Scaffold Protein 3 3 4
  • JNK-Interacting Protein 3 3 4
  • JIP-3 3 4
  • JIP3 3 4
  • JNK/Stress-Activated Protein Kinase-Associated Protein 1 3
  • Mitogen-Activated Protein Kinase 8-Interacting Protein 3 4
  • C-Jun-Amino-Terminal Kinase-Interacting Protein 3 3
  • C-Jun-Amino-Terminal Kinase Interacting Protein 3 3
  • JNK/SAPK-Associated Protein-1 3
  • KIAA1066 4
  • JSAP1 3
  • SYD2 3
  • Syd 3

External Ids for MAPK8IP3 Gene

Previous GeneCards Identifiers for MAPK8IP3 Gene

  • GC16P001773
  • GC16P001696
  • GC16P001756

Summaries for MAPK8IP3 Gene

Entrez Gene Summary for MAPK8IP3 Gene

  • The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK8IP3 Gene

MAPK8IP3 (Mitogen-Activated Protein Kinase 8 Interacting Protein 3) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Arf6 trafficking events. GO annotations related to this gene include kinesin binding and receptor signaling complex scaffold activity. An important paralog of this gene is SPAG9.

UniProtKB/Swiss-Prot for MAPK8IP3 Gene

  • The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).

Gene Wiki entry for MAPK8IP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK8IP3 Gene

Genomics for MAPK8IP3 Gene

Regulatory Elements for MAPK8IP3 Gene

Enhancers for MAPK8IP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G001645 1.5 FANTOM5 Ensembl ENCODE 11.9 -58.8 -58771 4.0 HDGF PKNOX1 ATF1 FOXA2 SIN3A ZNF121 ZNF766 FOS ZNF592 ZNF579 JPT2 ENSG00000226890 CRAMP1 IFT140 MAPK8IP3 TMEM204 CCDC154 TELO2 CLCN7 GC16P001635
GH16G001677 1.3 ENCODE dbSUPER 11.9 -26.6 -26567 4.3 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 JPT2 FAHD1 TELO2 ERVK13-1 EME2 MAPK8IP3 ENSG00000260051 PTX4 CLCN7 RPS3AP2
GH16G001825 1.4 ENCODE dbSUPER 10.6 +122.4 122433 6.9 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 FAHD1 HAGH JPT2 ENSG00000261505 ENSG00000261123 IFT140 ENSG00000260646 SNORA64 ENSG00000260954 ENSG00000255513
GH16G001308 1.4 ENCODE dbSUPER 10.1 -395.4 -395429 5.2 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MCM3 JPT2 ENSG00000261505 ENSG00000260051 RHOT2 JMJD8 ENSG00000260646 ENSG00000260954 SNORA64 ENSG00000255513 NME3
GH16G001832 1.3 ENCODE dbSUPER 10.4 +127.3 127261 1.7 FOXA2 PKNOX1 MLX ARNT ARID4B ZNF766 KLF13 SP5 ZHX2 SMARCB1 FAHD1 HAGH IGFALS MEIOB MAPK8IP3 JPT2 GC16M001829 PIR46763 GC16M001827
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAPK8IP3 on UCSC Golden Path with GeneCards custom track

Promoters for MAPK8IP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082374 117 2601 HDGF PKNOX1 MLX ARNT CREB3L1 AGO1 ARID4B SIN3A ZNF2 ZBTB7B

Genomic Location for MAPK8IP3 Gene

Chromosome:
16
Start:
1,706,183 bp from pter
End:
1,770,317 bp from pter
Size:
64,135 bases
Orientation:
Plus strand

Genomic View for MAPK8IP3 Gene

Genes around MAPK8IP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK8IP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK8IP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK8IP3 Gene

Proteins for MAPK8IP3 Gene

  • Protein details for MAPK8IP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPT6-JIP3_HUMAN
    Recommended name:
    C-Jun-amino-terminal kinase-interacting protein 3
    Protein Accession:
    Q9UPT6
    Secondary Accessions:
    • A2A2B3
    • A7E2B3
    • Q96RY4
    • Q9H4I4
    • Q9H7P1
    • Q9NUG0

    Protein attributes for MAPK8IP3 Gene

    Size:
    1336 amino acids
    Molecular mass:
    147457 Da
    Quaternary structure:
    • Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal of MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 to the N-terminal region, MAP2K4/MKK4 and MAP2K7/MKK7 to the central region and MAP3K11 to the C-terminal region. Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (By similarity). Interacts with ROCK1 and this interaction is enhanced by ultraviolet-B (UVB) radiation.
    SequenceCaution:
    • Sequence=AAK61290.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA83018.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15727.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB72318.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAPK8IP3 Gene

    Alternative splice isoforms for MAPK8IP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK8IP3 Gene

Post-translational modifications for MAPK8IP3 Gene

  • Phosphorylation by ROCK1 is crucial for the recruitment of JNK.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAPK8IP3 Gene

Domains & Families for MAPK8IP3 Gene

Suggested Antigen Peptide Sequences for MAPK8IP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPT6

UniProtKB/Swiss-Prot:

JIP3_HUMAN :
  • Belongs to the JIP scaffold family.
Family:
  • Belongs to the JIP scaffold family.
genes like me logo Genes that share domains with MAPK8IP3: view

No data available for Gene Families for MAPK8IP3 Gene

Function for MAPK8IP3 Gene

Molecular function for MAPK8IP3 Gene

UniProtKB/Swiss-Prot Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).

Gene Ontology (GO) - Molecular Function for MAPK8IP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005078 MAP-kinase scaffold activity IEA,ISS --
GO:0005515 protein binding IPI 27107012
GO:0008432 JUN kinase binding IEA,IBA --
GO:0019894 kinesin binding IEA,ISS --
GO:0030159 receptor signaling complex scaffold activity IBA --
genes like me logo Genes that share ontologies with MAPK8IP3: view
genes like me logo Genes that share phenotypes with MAPK8IP3: view

Animal Models for MAPK8IP3 Gene

MGI Knock Outs for MAPK8IP3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK8IP3 Gene

Localization for MAPK8IP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK8IP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK8IP3 gene
Compartment Confidence
golgi apparatus 4
nucleus 3
cytosol 3
cytoskeleton 2
endosome 1

Gene Ontology (GO) - Cellular Components for MAPK8IP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane ISS --
GO:0005737 cytoplasm IEA,IBA --
GO:0005790 smooth endoplasmic reticulum IEA --
GO:0005886 plasma membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with MAPK8IP3: view

Pathways & Interactions for MAPK8IP3 Gene

genes like me logo Genes that share pathways with MAPK8IP3: view

Pathways by source for MAPK8IP3 Gene

SIGNOR curated interactions for MAPK8IP3 Gene

Gene Ontology (GO) - Biological Process for MAPK8IP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0007254 JNK cascade IEA --
GO:0007257 activation of JUN kinase activity IEA,IBA --
GO:0007411 axon guidance IEA --
GO:0007585 respiratory gaseous exchange IEA --
genes like me logo Genes that share ontologies with MAPK8IP3: view

Drugs & Compounds for MAPK8IP3 Gene

(1) Drugs for MAPK8IP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MAPK8IP3: view

Transcripts for MAPK8IP3 Gene

Unigene Clusters for MAPK8IP3 Gene

Mitogen-activated protein kinase 8 interacting protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8IP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - -
SP17:
SP18:

ExUns: 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for MAPK8IP3 Gene

GeneLoc Exon Structure for
MAPK8IP3
ECgene alternative splicing isoforms for
MAPK8IP3

Expression for MAPK8IP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPK8IP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPK8IP3 Gene

This gene is overexpressed in Brain (28.8), Frontal cortex (10.7), and Prostate (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPK8IP3 Gene



Protein tissue co-expression partners for MAPK8IP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAPK8IP3 Gene:

MAPK8IP3

SOURCE GeneReport for Unigene cluster for MAPK8IP3 Gene:

Hs.207763

Evidence on tissue expression from TISSUES for MAPK8IP3 Gene

  • Nervous system(4.8)
  • Spleen(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK8IP3 Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Organs:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with MAPK8IP3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAPK8IP3 Gene

Orthologs for MAPK8IP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK8IP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK8IP3 35 34
  • 99.03 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPK8IP3 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK8IP3 35 34
  • 89.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK8IP3 35 34
  • 89.09 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK8IP3 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk8ip3 34
  • 86.4 (n)
mouse
(Mus musculus)
Mammalia Mapk8ip3 16 35 34
  • 86.38 (n)
chicken
(Gallus gallus)
Aves MAPK8IP3 34 35
  • 80.26 (n)
lizard
(Anolis carolinensis)
Reptilia MAPK8IP3 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk8ip3 34
  • 77.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14022 34
zebrafish
(Danio rerio)
Actinopterygii mapk8ip3 35 34
  • 70.78 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta syd 36 35
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-16 36 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
Species where no ortholog for MAPK8IP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK8IP3 Gene

ENSEMBL:
Gene Tree for MAPK8IP3 (if available)
TreeFam:
Gene Tree for MAPK8IP3 (if available)

Paralogs for MAPK8IP3 Gene

Paralogs for MAPK8IP3 Gene

(3) SIMAP similar genes for MAPK8IP3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MAPK8IP3: view

Variants for MAPK8IP3 Gene

Sequence variations from dbSNP and Humsavar for MAPK8IP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000005360 -- 1,741,098(+) CAGTC(A/G)GACCT intron-variant
rs1000060130 -- 1,732,816(+) AACTA(C/T)GCCAG intron-variant
rs1000080954 -- 1,770,394(+) GGCTG(C/G)GCACC downstream-variant-500B, utr-variant-3-prime
rs1000086819 -- 1,748,727(+) TAAGC(A/G)CAAGC intron-variant
rs1000098190 -- 1,740,990(+) GTCAC(A/C)GACGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK8IP3 Gene

Variant ID Type Subtype PubMed ID
dgv4856n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv2667640 CNV deletion 23128226
esv2750350 CNV deletion 23290073
esv2750352 CNV deletion 23290073
esv2750353 CNV deletion 23290073
esv2750354 CNV deletion 23290073
esv2750355 CNV deletion 23290073
esv2750356 CNV deletion 23290073
esv2750357 CNV deletion 23290073
esv2750358 CNV deletion 23290073
esv2750359 CNV deletion 23290073
esv2750360 CNV deletion 23290073
esv2750361 CNV deletion 23290073
esv2750364 CNV deletion 23290073
esv2750365 CNV deletion 23290073
esv2750366 CNV deletion 23290073
esv2750367 CNV deletion 23290073
esv2750368 CNV deletion 23290073
esv2750369 CNV deletion 23290073
esv27589 CNV loss 19812545
esv3323889 CNV duplication 20981092
esv3368378 CNV duplication 20981092
esv3637623 CNV loss 21293372
esv3892756 CNV loss 25118596
nsv1051692 CNV loss 25217958
nsv1075908 CNV duplication 25765185
nsv1116104 CNV deletion 24896259
nsv1160328 CNV deletion 26073780
nsv428317 CNV gain 18775914
nsv457335 CNV loss 19166990
nsv457336 CNV loss 19166990
nsv471069 CNV loss 18288195
nsv517196 CNV gain+loss 19592680
nsv518641 CNV loss 19592680
nsv571169 CNV loss 21841781
nsv571170 CNV loss 21841781
nsv571171 CNV gain+loss 21841781
nsv571172 CNV loss 21841781
nsv571173 CNV loss 21841781
nsv827499 CNV gain 20364138
nsv827500 CNV gain 20364138
nsv833118 CNV loss 17160897
nsv952900 CNV deletion 24416366

Variation tolerance for MAPK8IP3 Gene

Residual Variation Intolerance Score: 0.355% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK8IP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK8IP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK8IP3 Gene

Disorders for MAPK8IP3 Gene

Relevant External Links for MAPK8IP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK8IP3

No disorders were found for MAPK8IP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPK8IP3 Gene

Publications for MAPK8IP3 Gene

  1. Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cells. (PMID: 19574423) Desai L.P. … Waters C.M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 3 22 64
  2. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. (PMID: 19036714) Ongusaha P.P. … Lee S.W. (Sci. Signal. 2008) 3 4 64
  3. Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. (PMID: 15911620) Song J.J. … Lee Y.J. (J. Biol. Chem. 2005) 3 22 64
  4. JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration. (PMID: 16141199) Takino T. … Sato H. (J. Biol. Chem. 2005) 3 22 64
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64

Products for MAPK8IP3 Gene

Sources for MAPK8IP3 Gene

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