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Aliases for MAPK8IP3 Gene

Aliases for MAPK8IP3 Gene

  • Mitogen-Activated Protein Kinase 8 Interacting Protein 3 2 3 5
  • Mitogen-Activated Protein Kinase 8-Interacting Protein 3 3 4
  • Homolog Of Drosophila Sunday Driver 2 2 3
  • JNK MAP Kinase Scaffold Protein 3 3 4
  • JNK-Interacting Protein 3 3 4
  • JIP-3 3 4
  • JIP3 3 4
  • JNK/Stress-Activated Protein Kinase-Associated Protein 1 3
  • C-Jun-Amino-Terminal Kinase Interacting Protein 3 3
  • JNK/SAPK-Associated Protein-1 3
  • KIAA1066 4
  • JSAP1 3
  • SYD2 3
  • Syd 3

External Ids for MAPK8IP3 Gene

Previous GeneCards Identifiers for MAPK8IP3 Gene

  • GC16P001773
  • GC16P001696
  • GC16P001756

Summaries for MAPK8IP3 Gene

Entrez Gene Summary for MAPK8IP3 Gene

  • The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK8IP3 Gene

MAPK8IP3 (Mitogen-Activated Protein Kinase 8 Interacting Protein 3) is a Protein Coding gene. Among its related pathways are ERK Signaling and Arf6 trafficking events. GO annotations related to this gene include kinesin binding and receptor signaling complex scaffold activity. An important paralog of this gene is ARHGEF10L.

UniProtKB/Swiss-Prot for MAPK8IP3 Gene

  • The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).

Gene Wiki entry for MAPK8IP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK8IP3 Gene

Genomics for MAPK8IP3 Gene

Regulatory Elements for MAPK8IP3 Gene

Promoters for MAPK8IP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAPK8IP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAPK8IP3 Gene

Chromosome:
16
Start:
1,706,183 bp from pter
End:
1,770,317 bp from pter
Size:
64,135 bases
Orientation:
Plus strand

Genomic View for MAPK8IP3 Gene

Genes around MAPK8IP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK8IP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK8IP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK8IP3 Gene

Proteins for MAPK8IP3 Gene

  • Protein details for MAPK8IP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPT6-JIP3_HUMAN
    Recommended name:
    C-Jun-amino-terminal kinase-interacting protein 3
    Protein Accession:
    Q9UPT6
    Secondary Accessions:
    • A2A2B3
    • A7E2B3
    • Q96RY4
    • Q9H4I4
    • Q9H7P1
    • Q9NUG0

    Protein attributes for MAPK8IP3 Gene

    Size:
    1336 amino acids
    Molecular mass:
    147457 Da
    Quaternary structure:
    • Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal of MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 to the N-terminal region, MAP2K4/MKK4 and MAP2K7/MKK7 to the central region and MAP3K11 to the C-terminal region. Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (By similarity). Interacts with ROCK1 and this interaction is enhanced by ultraviolet-B (UVB) radiation.
    SequenceCaution:
    • Sequence=AAK61290.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA83018.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB15727.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAB72318.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAPK8IP3 Gene

    Alternative splice isoforms for MAPK8IP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK8IP3 Gene

Proteomics data for MAPK8IP3 Gene at MOPED

Post-translational modifications for MAPK8IP3 Gene

  • Phosphorylation by ROCK1 is crucial for the recruitment of JNK.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK8IP3 Gene

Antibody Products

No data available for DME Specific Peptides for MAPK8IP3 Gene

Domains & Families for MAPK8IP3 Gene

Protein Domains for MAPK8IP3 Gene

Suggested Antigen Peptide Sequences for MAPK8IP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPT6

UniProtKB/Swiss-Prot:

JIP3_HUMAN :
  • Contains 1 RH1 domain.
  • Belongs to the JIP scaffold family.
Domain:
  • Contains 1 RH1 domain.
  • Contains 1 RH2 domain.
Family:
  • Belongs to the JIP scaffold family.
genes like me logo Genes that share domains with MAPK8IP3: view

No data available for Gene Families for MAPK8IP3 Gene

Function for MAPK8IP3 Gene

Molecular function for MAPK8IP3 Gene

UniProtKB/Swiss-Prot Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).
genes like me logo Genes that share phenotypes with MAPK8IP3: view

Human Phenotype Ontology for MAPK8IP3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAPK8IP3 Gene

MGI Knock Outs for MAPK8IP3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for MAPK8IP3 Gene

Localization for MAPK8IP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK8IP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK8IP3 Gene COMPARTMENTS Subcellular localization image for MAPK8IP3 gene
Compartment Confidence
golgi apparatus 4
cytosol 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
plasma membrane 2
endosome 1

Gene Ontology (GO) - Cellular Components for MAPK8IP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with MAPK8IP3: view

Pathways & Interactions for MAPK8IP3 Gene

genes like me logo Genes that share pathways with MAPK8IP3: view

Pathways by source for MAPK8IP3 Gene

SIGNOR curated interactions for MAPK8IP3 Gene

Gene Ontology (GO) - Biological Process for MAPK8IP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007254 JNK cascade IEA --
GO:0007411 axon guidance IEA --
GO:0009791 post-embryonic development IEA --
GO:0030900 forebrain development IEA --
GO:0043507 positive regulation of JUN kinase activity IEA --
genes like me logo Genes that share ontologies with MAPK8IP3: view

Drugs & Compounds for MAPK8IP3 Gene

(1) Additional Compounds for MAPK8IP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAPK8IP3: view

Transcripts for MAPK8IP3 Gene

Unigene Clusters for MAPK8IP3 Gene

Mitogen-activated protein kinase 8 interacting protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8IP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - -
SP17:
SP18:

ExUns: 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b
SP1:
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for MAPK8IP3 Gene

GeneLoc Exon Structure for
MAPK8IP3
ECgene alternative splicing isoforms for
MAPK8IP3

Expression for MAPK8IP3 Gene

mRNA expression in normal human tissues for MAPK8IP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPK8IP3 Gene

This gene is overexpressed in Brain (28.8), Frontal cortex (10.7), and Prostate (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK8IP3 Gene



SOURCE GeneReport for Unigene cluster for MAPK8IP3 Gene Hs.207763

genes like me logo Genes that share expression patterns with MAPK8IP3: view

Protein tissue co-expression partners for MAPK8IP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAPK8IP3 Gene

Orthologs for MAPK8IP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK8IP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK8IP3 36
  • 100 (a)
OneToOne
MAPK8IP3 35
  • 99.03 (n)
  • 99.48 (a)
cow
(Bos Taurus)
Mammalia MAPK8IP3 36
  • 94 (a)
OneToOne
MAPK8IP3 35
  • 89.96 (n)
  • 93.75 (a)
dog
(Canis familiaris)
Mammalia MAPK8IP3 35
  • 89.09 (n)
  • 93.33 (a)
MAPK8IP3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk8ip3 36
  • 94 (a)
OneToOne
Mapk8ip3 16
Mapk8ip3 35
  • 86.38 (n)
  • 93.79 (a)
oppossum
(Monodelphis domestica)
Mammalia MAPK8IP3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK8IP3 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk8ip3 35
  • 86.4 (n)
  • 94.1 (a)
chicken
(Gallus gallus)
Aves MAPK8IP3 35
  • 80.26 (n)
  • 88.61 (a)
MAPK8IP3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK8IP3 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14022 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk8ip3 35
  • 77.03 (n)
  • 86.77 (a)
zebrafish
(Danio rerio)
Actinopterygii mapk8ip3 36
  • 72 (a)
OneToOne
mapk8ip3 35
  • 70.78 (n)
  • 74.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta syd 37
  • 46 (a)
syd 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea unc-16 36
  • 40 (a)
OneToOne
unc-16 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for MAPK8IP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK8IP3 Gene

ENSEMBL:
Gene Tree for MAPK8IP3 (if available)
TreeFam:
Gene Tree for MAPK8IP3 (if available)

Paralogs for MAPK8IP3 Gene

Paralogs for MAPK8IP3 Gene

(3) SIMAP similar genes for MAPK8IP3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MAPK8IP3: view

Variants for MAPK8IP3 Gene

Sequence variations from dbSNP and Humsavar for MAPK8IP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2294619 - 1,764,439(+) CCCAC(A/G)CGTCT reference, missense
rs747254 -- 1,752,517(-) gatcc(C/T)cctgc intron-variant
rs2143284 -- 1,768,137(+) CTCAC(A/G)GGAGC intron-variant
rs2076428 -- 1,767,767(+) TGGGG(G/T)GCTCA intron-variant
rs2294620 -- 1,764,785(+) CTTGG(A/G)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK8IP3 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904954 CNV Loss 21882294
nsv905017 CNV Loss 21882294
nsv428317 CNV Gain 18775914
nsv833118 CNV Loss 17160897
nsv518641 CNV Loss 19592680
esv2667640 CNV Deletion 23128226
esv2750350 CNV Deletion 23290073
esv2750352 CNV Deletion 23290073
nsv457335 CNV Loss 19166990
dgv2538n71 CNV Loss 21882294
nsv517196 CNV Gain+Loss 19592680
nsv905023 CNV Gain 21882294
esv27589 CNV Loss 19812545
esv2750353 CNV Deletion 23290073
esv2750354 CNV Deletion 23290073
esv2750355 CNV Deletion 23290073
esv2750356 CNV Deletion 23290073
esv2750357 CNV Deletion 23290073
esv2750358 CNV Deletion 23290073
esv2750359 CNV Deletion 23290073
esv2750360 CNV Deletion 23290073
esv2750361 CNV Deletion 23290073
esv2750364 CNV Deletion 23290073
esv2750365 CNV Deletion 23290073
dgv2539n71 CNV Loss 21882294
dgv2540n71 CNV Loss 21882294
esv2750366 CNV Deletion 23290073
esv2750367 CNV Deletion 23290073
esv2750368 CNV Deletion 23290073
esv2750369 CNV Deletion 23290073
nsv457336 CNV Loss 19166990
nsv827499 CNV Gain 20364138
nsv905030 CNV Loss 21882294
nsv471069 CNV Loss 18288195
dgv2541n71 CNV Loss 21882294
nsv905031 CNV Gain+Loss 21882294
dgv2542n71 CNV Loss 21882294
nsv905034 CNV Loss 21882294
nsv827500 CNV Gain 20364138
dgv2543n71 CNV Loss 21882294
nsv905039 CNV Loss 21882294

Variation tolerance for MAPK8IP3 Gene

Residual Variation Intolerance Score: 0.355% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK8IP3 Gene

HapMap Linkage Disequilibrium report
MAPK8IP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK8IP3 Gene

Disorders for MAPK8IP3 Gene

Relevant External Links for MAPK8IP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK8IP3

No disorders were found for MAPK8IP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPK8IP3 Gene

Publications for MAPK8IP3 Gene

  1. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. (PMID: 19036714) Ongusaha P.P. … Lee S.W. (Sci. Signal. 2008) 3 4 67
  2. Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cells. (PMID: 19574423) Desai L.P. … Waters C.M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 3 23
  3. Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. (PMID: 15911620) Song J.J. … Lee Y.J. (J. Biol. Chem. 2005) 3 23
  4. JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration. (PMID: 16141199) Takino T. … Sato H. (J. Biol. Chem. 2005) 3 23
  5. A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated. (PMID: 12226752) Takino T. … Sato H. (Oncogene 2002) 3 23

Products for MAPK8IP3 Gene

Sources for MAPK8IP3 Gene

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