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Aliases for MAPK8IP2 Gene

Aliases for MAPK8IP2 Gene

  • Mitogen-Activated Protein Kinase 8 Interacting Protein 2 2 3
  • JNK-Interacting Protein 2 2 3 4
  • JIP2 3 4 6
  • IB2 3 4 6
  • JNK MAP Kinase Scaffold Protein 2 3 4
  • Islet-Brain 2 2 3
  • PRKM8IPL 3 4
  • IB-2 3 4
  • Mitogen-Activated Protein Kinase 8-Interacting Protein 2 4
  • C-Jun-Amino-Terminal Kinase-Interacting Protein 2 3
  • JNK MAP Kinase Scaffold Protein JIP2 3
  • PRKM8 Interacting Protein-Like 2
  • Homologous To Mouse JIP-1 3
  • Islet-Brain-2 4
  • JIP-2 4

External Ids for MAPK8IP2 Gene

Previous HGNC Symbols for MAPK8IP2 Gene

  • PRKM8IPL

Previous GeneCards Identifiers for MAPK8IP2 Gene

  • GC22P047543
  • GC22P049171
  • GC22P049329
  • GC22P049385
  • GC22P051039
  • GC22P033930

Summaries for MAPK8IP2 Gene

Entrez Gene Summary for MAPK8IP2 Gene

  • The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. [provided by RefSeq, Feb 2014]

GeneCards Summary for MAPK8IP2 Gene

MAPK8IP2 (Mitogen-Activated Protein Kinase 8 Interacting Protein 2) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Akt Signaling. GO annotations related to this gene include protein kinase binding and beta-amyloid binding. An important paralog of this gene is MAPK8IP1.

UniProtKB/Swiss-Prot for MAPK8IP2 Gene

  • The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).

Gene Wiki entry for MAPK8IP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK8IP2 Gene

Genomics for MAPK8IP2 Gene

Regulatory Elements for MAPK8IP2 Gene

Genomic Location for MAPK8IP2 Gene

Start:
50,600,685 bp from pter
End:
50,613,981 bp from pter
Size:
13,297 bases
Orientation:
Plus strand

Genomic View for MAPK8IP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPK8IP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK8IP2 Gene

Proteins for MAPK8IP2 Gene

  • Protein details for MAPK8IP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13387-JIP2_HUMAN
    Recommended name:
    C-Jun-amino-terminal kinase-interacting protein 2
    Protein Accession:
    Q13387
    Secondary Accessions:
    • Q96G62
    • Q99771
    • Q9NZ59
    • Q9UKQ4

    Protein attributes for MAPK8IP2 Gene

    Size:
    824 amino acids
    Molecular mass:
    87975 Da
    Quaternary structure:
    • Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely JNK1, JNK2, JNK3, MAP2K7, MAP3K10, MAP3K11, MAP3K12 and MAPK13. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of kinesin light chain, Klc1, pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location (By similarity). Interacts with the cytoplasmic domain of APP (By similarity). Interacts with DCLK2. Interacts with TIAM1 and TIAM2 (By similarity). Interacts with FGF13; enables the interaction with MAPK13 and may regulate the MAPK8IP2 scaffolding activity.
    SequenceCaution:
    • Sequence=CAA16714.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAPK8IP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK8IP2 Gene

Proteomics data for MAPK8IP2 Gene at MOPED

Post-translational modifications for MAPK8IP2 Gene

  • Ubiquitination at Lys668
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPK8IP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAPK8IP2 Gene

Domains for MAPK8IP2 Gene

Protein Domains for MAPK8IP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13387

UniProtKB/Swiss-Prot:

JIP2_HUMAN :
  • Q13387
Domain:
  • Contains 1 PID domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the JIP scaffold family.
genes like me logo Genes that share domains with MAPK8IP2: view

No data available for Gene Families for MAPK8IP2 Gene

Function for MAPK8IP2 Gene

Molecular function for MAPK8IP2 Gene

GENATLAS Biochemistry: mitogen-activated protein kinase 8 interacting protein 2,,homolog to mus musculus JIR1 gene
UniProtKB/Swiss-Prot Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).

Gene Ontology (GO) - Molecular Function for MAPK8IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding NAS 12023290
GO:0005078 MAP-kinase scaffold activity NAS 10490659
GO:0005198 structural molecule activity TAS 10490659
GO:0005515 protein binding IPI 16273093
GO:0019894 kinesin binding ISS --
genes like me logo Genes that share ontologies with MAPK8IP2: view
genes like me logo Genes that share phenotypes with MAPK8IP2: view

Animal Models for MAPK8IP2 Gene

MGI Knock Outs for MAPK8IP2:

miRNA for MAPK8IP2 Gene

miRTarBase miRNAs that target MAPK8IP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MAPK8IP2 Gene

Localization for MAPK8IP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK8IP2 Gene

Cytoplasm. Note=Accumulates in cell surface projections.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK8IP2 Gene COMPARTMENTS Subcellular localization image for MAPK8IP2 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for MAPK8IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10490659
GO:0043025 neuronal cell body IEA --
GO:0043234 protein complex IEA --
GO:0097481 neuronal postsynaptic density ISS --
genes like me logo Genes that share ontologies with MAPK8IP2: view

Pathways for MAPK8IP2 Gene

genes like me logo Genes that share pathways with MAPK8IP2: view

Pathways by source for MAPK8IP2 Gene

Gene Ontology (GO) - Biological Process for MAPK8IP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IDA 12244047
GO:0001662 behavioral fear response ISS --
GO:0007172 signal complex assembly TAS 10490659
GO:0007254 JNK cascade IEA --
GO:0007617 mating behavior IEA --
genes like me logo Genes that share ontologies with MAPK8IP2: view

Transcripts for MAPK8IP2 Gene

mRNA/cDNA for MAPK8IP2 Gene

Unigene Clusters for MAPK8IP2 Gene

Mitogen-activated protein kinase 8 interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8IP2 Gene

No ASD Table

Relevant External Links for MAPK8IP2 Gene

GeneLoc Exon Structure for
MAPK8IP2
ECgene alternative splicing isoforms for
MAPK8IP2

Expression for MAPK8IP2 Gene

mRNA expression in normal human tissues for MAPK8IP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK8IP2 Gene

This gene is overexpressed in Brain - Cortex (5.7), Brain - Cerebellum (5.5), Brain - Amygdala (5.1), Brain - Anterior cingulate cortex (BA24) (5.0), Brain - Cerebellar Hemisphere (4.8), Brain - Frontal Cortex (BA9) (4.8), and Brain - Hippocampus (4.4).

SOURCE GeneReport for Unigene cluster for MAPK8IP2 Gene Hs.558180

mRNA Expression by UniProt/SwissProt for MAPK8IP2 Gene

Q13387-JIP2_HUMAN
Tissue specificity: Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland
genes like me logo Genes that share expressions with MAPK8IP2: view

No data available for Protein expression for MAPK8IP2 Gene

Orthologs for MAPK8IP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK8IP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK8IP2 35
  • 99.15 (n)
  • 99.51 (a)
MAPK8IP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK8IP2 35
  • 86.86 (n)
  • 89.07 (a)
MAPK8IP2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK8IP2 35
  • 87.28 (n)
  • 88.59 (a)
MAPK8IP2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk8ip2 35
  • 82.76 (n)
  • 87.93 (a)
Mapk8ip2 16
Mapk8ip2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPK8IP2 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK8IP2 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk8ip2 35
  • 82.52 (n)
  • 86.62 (a)
chicken
(Gallus gallus)
Aves MAPK8IP2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk8ip2 35
  • 61.13 (n)
  • 63 (a)
zebrafish
(Danio rerio)
Actinopterygii mapk8ip2 35
  • 62.01 (n)
  • 62.63 (a)
mapk8ip2 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Aplip1 36
  • 25 (a)
OneToMany
Aplip1 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea jip-1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for MAPK8IP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK8IP2 Gene

ENSEMBL:
Gene Tree for MAPK8IP2 (if available)
TreeFam:
Gene Tree for MAPK8IP2 (if available)

Paralogs for MAPK8IP2 Gene

Paralogs for MAPK8IP2 Gene

Selected SIMAP similar genes for MAPK8IP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MAPK8IP2: view

Variants for MAPK8IP2 Gene

Sequence variations from dbSNP and Humsavar for MAPK8IP2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs14136 -- 50,610,293(+) AGGCC(A/G)GTGGC synonymous-codon, reference
rs131733 -- 50,609,505(-) GACAG(C/T)GTGTG intron-variant
rs131734 -- 50,607,388(-) GCCTA(C/T)ATAGC intron-variant
rs131735 -- 50,607,052(-) GGGGG(C/T)GGTTG intron-variant
rs131736 -- 50,607,005(-) GGGAC(A/G)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK8IP2 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
nsv914542 CNV Loss 21882294
nsv914543 CNV Loss 21882294
nsv834239 CNV Loss 17160897
dgv5066n71 CNV Loss 21882294
nsv829340 CNV Gain 20364138
dgv5067n71 CNV Loss 21882294
nsv914559 CNV Loss 21882294
dgv5068n71 CNV Loss 21882294
nsv829342 CNV Loss 20364138
dgv5069n71 CNV Loss 21882294
nsv914566 CNV Loss 21882294
nsv829343 CNV Gain 20364138

Relevant External Links for MAPK8IP2 Gene

HapMap Linkage Disequilibrium report
MAPK8IP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK8IP2 Gene

Disorders for MAPK8IP2 Gene

No disorders were found for MAPK8IP2 Gene.

No data available for UniProtKB/Swiss-Prot for MAPK8IP2 Gene

Publications for MAPK8IP2 Gene

  1. The JIP group of mitogen-activated protein kinase scaffold proteins. (PMID: 10490659) Yasuda J. … Davis R.J. (Mol. Cell. Biol. 1999) 2 3 4 23
  2. cDNA cloning and mapping of a novel islet-brain/JNK interacting protein. (PMID: 10756100) Negri S. … Bonny C. (Genomics 2000) 3 4 23
  3. Fibroblast growth factor homologous factors are intracellular signaling proteins. (PMID: 11378392) Schoorlemmer J. … Goldfarb M. (Curr. Biol. 2001) 3 4 23
  4. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3 4

Products for MAPK8IP2 Gene

Sources for MAPK8IP2 Gene

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