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MAPK8IP2 Gene

protein-coding   GIFtS: 60
GCID: GC22P051039

Mitogen-Activated Protein Kinase 8 Interacting Protein 2

(Previous name: PRKM8 interacting protein-like)
(Previous symbol: PRKM8IPL)
  See MAPK8IP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 8 Interacting Protein 21 2     PRKM8 Interacting Protein-Like1
PRKM8IPL1 2 3     C-Jun-Amino-Terminal Kinase-Interacting Protein 22
JNK-Interacting Protein 21 2 3     Homologous To Mouse JIP-12
IB22 3 5     JNK MAP Kinase Scaffold Protein JIP22
JIP22 3 5     Islet-brain-23
Islet-Brain 21 2     JIP-23
IB-22 3     Mitogen-Activated Protein Kinase 8-Interacting Protein 23
JNK MAP Kinase Scaffold Protein 22 3     

External Ids:    HGNC: 68831   Entrez Gene: 235422   Ensembl: ENSG000000087357   OMIM: 6077555   UniProtKB: Q133873   

Export aliases for MAPK8IP2 gene to outside databases

Previous GC identifers: GC22P047543 GC22P049171 GC22P049329 GC22P049385 GC22P033930


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK8IP2 Gene:
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in
the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It
has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein
thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and
pancreatic beta-cells. (provided by RefSeq, Feb 2014)

GeneCards Summary for MAPK8IP2 Gene:
MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2) is a protein-coding gene. Diseases associated with MAPK8IP2 include ameloblastic carcinoma. GO annotations related to this gene include beta-amyloid binding and protein kinase binding. An important paralog of this gene is MAPK8IP1.

UniProtKB/Swiss-Prot: JIP2_HUMAN, Q13387
Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1
beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through
interactions with the JNK-signaling components and motor proteins (By similarity)

Gene Wiki entry for MAPK8IP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011526.8  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK8IP2 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAPK8IP2 promoter sequence
   Search Chromatin IP Primers for MAPK8IP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK8IP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

MAPK8IP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK8IP2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P051039:  view genomic region     (about GC identifiers)

Start:
51,039,114 bp from pter      End:
51,052,409 bp from pter
Size:
13,296 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: JIP2_HUMAN, Q13387 (See protein sequence)
Recommended Name: C-Jun-amino-terminal kinase-interacting protein 2  
Size: 824 amino acids; 87975 Da
Subunit: Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely
JNK1, JNK2, JNK3, MAP2K7, MAP3K10, MAP3K11, MAP3K12 and MAPK13. Also binds the proline-rich domain-containing
splice variant of apolipoprotein E receptor 2 (ApoER2). Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin).
Binds the TPR motif-containing C-terminal of kinesin light chain, Klc1, pre-assembled MAPK8IP1 scaffolding
complexes are then transported as a cargo of kinesin, to the required subcellular location (By similarity).
Interacts with the cytoplasmic domain of APP (By similarity). Interacts with DCLK2. Interacts with TIAM1 and
TIAM2 (By similarity). Interacts with FGF13; enables the interaction with MAPK13 and may regulate the MAPK8IP2
scaffolding activity
Sequence caution: Sequence=CAA16714.1; Type=Erroneous initiation;
Secondary accessions: Q96G62 Q99771 Q9NZ59 Q9UKQ4
Alternative splicing: 4 isoforms:  Q13387-1   Q13387-2   Q13387-3   Q13387-4   (Might be artifactual as it is only predicted from a genomic sequence)

Explore the universe of human proteins at neXtProt for MAPK8IP2: NX_Q13387

Explore proteomics data for MAPK8IP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys668
  • Modification sites at PhosphoSitePlus

  • See MAPK8IP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_036456.1  NP_057515.1  

    ENSEMBL proteins: 
     ENSP00000382796   ENSP00000382792   ENSP00000330572   ENSP00000404914   ENSP00000340015  
     ENSP00000008876  

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    antibodies-online proteins for MAPK8IP2 (6 products) 

     
    antibodies-online peptides for MAPK8IP2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR006020 PTB/PI_dom

    Graphical View of Domain Structure for InterPro Entry Q13387

    ProtoNet protein and cluster: Q13387

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: JIP2_HUMAN, Q13387
    Similarity: Belongs to the JIP scaffold family
    Similarity: Contains 1 PID domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with MAPK8IP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JIP2_HUMAN, Q13387
    Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
    aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1
    beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through
    interactions with the JNK-signaling components and motor proteins (By similarity)

         Genatlas biochemistry entry for MAPK8IP2:
    mitogen-activated protein kinase 8 interacting protein 2,,homolog to mus musculus JIR1 gene

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding NAS12023290
    GO:0005078MAP-kinase scaffold activity NAS10490659
    GO:0005198structural molecule activity TAS10490659
    GO:0005515protein binding IPI16273093
    GO:0019894kinesin binding ISS--
         
    Find genes that share ontologies with MAPK8IP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MAPK8IP2:
     Increased viability with 4OH t 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mapk8ip2):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  mortality/aging 
     nervous system  no phenotypic analysis  reproductive system  taste/olfaction  vision/eye 

    Find genes that share phenotypes with MAPK8IP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MAPK8IP2: Mapk8ip2tm1Rjd Mapk8ip2tm1.1Gol

       genOway: Develop your customized and physiologically relevant rodent model for MAPK8IP2

    miRNA
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    miRTarBase miRNAs that target MAPK8IP2:
    hsa-mir-296-3p (MIRT038432)

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    hsa-miR-623 hsa-miR-3163 hsa-miR-148b* hsa-miR-502-5p hsa-miR-188-5p hsa-miR-503 hsa-miR-4282 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidMAPK8IP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAPK8IP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JIP2_HUMAN, Q13387: Cytoplasm. Note=Accumulates in cell surface projections
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10490659
    GO:0014069postsynaptic density ----
    GO:0043025neuronal cell body ----
    GO:0043234protein complex ----
    GO:0097481neuronal postsynaptic density ISS--

    Find genes that share ontologies with MAPK8IP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK8IP2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Akt Signaling
    p38 Signaling0.60
    2ERK Signaling
    MAPK Signaling0.58
    3TGF-Beta Pathway
    JNK Pathway0.51
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    5Reelin Pathway (Cajal-Retzius cells)
    Reelin Pathway (Cajal-Retzius cells)


    Find genes that share SuperPaths with MAPK8IP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK8IP2
        MAPK Signaling
    Guidance Cues and Growth Cone Motility
    Reelin Pathway (Cajal-Retzius cells)
    JNK Pathway
    p38 Signaling


    1 Kegg Pathway  (Kegg details for MAPK8IP2):
        MAPK signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK8IP2: 
              Apoptosis 384HT in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK8IP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK8IP2 (Q133871, 2, 3 ENSP000003305724) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-722813,EBI-641062 MINT-74580 MINT-74581 MINT-74579 I2D: score=2 STRING: ENSP00000269571
    MAGED4Q96JG82, 3MINT-8262521 I2D: score=2 
    MAGED4BQ96JG82, 3MINT-8262521 I2D: score=2 
    PRSS23O950842, 3MINT-63250 I2D: score=5 
    AFG3L2Q9Y4W62, 3MINT-8262385 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IDA12244047
    GO:0001662behavioral fear response ISS--
    GO:0007172signal complex assembly TAS10490659
    GO:0007254JNK cascade ----
    GO:0007617mating behavior ----

    Find genes that share ontologies with MAPK8IP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPK8IP2 (JIP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAPK8IP2 gene (3 alternative transcripts): 
    NM_012324.4  NM_016431.3  NM_139124.1  

    Unigene Cluster for MAPK8IP2:

    Mitogen-activated protein kinase 8 interacting protein 2
    Hs.558180  [show with all ESTs]
    Unigene Representative Sequence: NM_012324
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399912(uc003bmx.3 uc011asc.2) ENST00000399908(uc003bmy.3)
    ENST00000329492 ENST00000442429 ENST00000341339 ENST00000008876
    miRNA
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    hsa-miR-623 hsa-miR-3163 hsa-miR-148b* hsa-miR-502-5p hsa-miR-188-5p hsa-miR-503 hsa-miR-4282 hsa-miR-340
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    Additional mRNA sequence: 

    AF136382.1 AF218778.1 AK293580.1 AK294265.1 AL021708.1 BC009940.2 BC037271.1 BC047527.1 
    U79261.1 

    4 DOTS entries:

    DT.92422219  DT.92422213  DT.447748  DT.100687205 

    Selected AceView cDNA sequences (see all 104):

    CA433394 BM704539 AF136382 BM054759 AI858973 AF218778 BQ270842 BU732443 
    BM709297 BM664062 CK904634 BC009940 CK904635 BM068796 NM_012324 U79261 
    BM671684 BX114580 NM_016431 NM_139124 BM672272 BU584829 AI377280 AI391732 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPK8IP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCAATAA
    MAPK8IP2 Expression
    About this image


    MAPK8IP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Long Bone
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Limb (Muscoskeletal System)
             Pelvic Girdle
    MAPK8IP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK8IP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558180

    UniProtKB/Swiss-Prot: JIP2_HUMAN, Q13387
    Tissue specificity: Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous
    system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also
    expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid
    gland and salivary gland

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK8IP2: 
              Apoptosis 384HT in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK8IP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAPK8IP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk8ip21 , 5 mitogen-activated protein kinase 8 interacting protein 2 less1, 5 82.76(n)1
    87.93(a)1
      15 (44.92 cM)5
    605971  NM_021921.31  NP_068740.31 
     894539135 
    chicken
    (Gallus gallus)
    Aves MAPK8IP26
    mitogen-activated protein kinase 8 interacting pro...
    70(a)
    1 ↔ 1
    AADN03019235.1(702-1855)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    61(a)
    52(a)
    many → 1
    many → 1
    GL344723.1(10142-19892)
    GL343837.1(42632-52712)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mapk8ip21 mitogen-activated protein kinase 8 interacting protein 2 less 61.13(n)
    63(a)
      100036643  NM_001097201.1  NP_001090670.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapk8ip21 mitogen-activated protein kinase 8 interacting protein 2 less 62.01(n)
    62.63(a)
      561262  XM_679994.6  XP_685086.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aplip13 regulation of JNK cascade kinesin
    binding
    40(a)   61F3   --
    worm
    (Caenorhabditis elegans)
    Secernentea jip-16
    Protein JIP-1, isoform a (jip-1) mRNA, complete cd...
    12(a)
    1 → many
    II(1326995-1350136) WBGene00002176


    ENSEMBL Gene Tree for MAPK8IP2 (if available)
    TreeFam Gene Tree for MAPK8IP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK8IP2 gene
    MAPK8IP12  
    1 SIMAP similar gene for MAPK8IP2 using alignment to 6 protein entries:     JIP2_HUMAN (see all proteins):
    MAPK8IP1

    Find genes that share paralogs with MAPK8IP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPK8IP2 (see all 350)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907069891,2
    --51037145(+) GTGACA/GCACCC 1 -- us2k10--------
    rs1817109451,2
    --51037229(+) AAAATA/GCTGTA 1 -- us2k10--------
    rs1389506541,2
    C--51037612(+) AGGCAC/TGAGAA 1 -- us2k10--------
    rs1126457071,2
    C,F--51037683(+) CTGGGC/GAACAG 1 -- us2k12Minor allele frequency- G:0.05WA NA 122
    rs1317381,2
    C,F,O--51037751(-) TTCTGT/CGGAAA 1 -- us2k14Minor allele frequency- C:0.29WA NA CSA 7
    rs734455561,2
    C,F--51037774(+) GAAATC/GTTAGG 1 -- us2k13Minor allele frequency- G:0.13WA NA 240
    rs1862722861,2
    --51037837(+) AGCCTC/TCTTCT 1 -- us2k10--------
    rs124841951,2
    H--51037868(+) tgctgG/Tggttc 1 -- us2k10--------
    rs60099351,2
    C--51038092(+) ctcagC/Tctccc 1 -- us2k10--------
    rs60099361,2
    C--51038095(+) agcctA/Cccaag 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPK8IP2 (51039114 - 51052409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAPK8IP2 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5069n71CNV Loss21882294
    nsv914559CNV Loss21882294
    nsv915495CNV Loss21882294
    nsv914566CNV Loss21882294
    dgv5068n71CNV Loss21882294
    nsv914543CNV Loss21882294
    nsv834239CNV Loss17160897
    dgv5066n71CNV Loss21882294
    nsv829342CNV Loss20364138
    dgv5067n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MAPK8IP2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK8IP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607755    OMIM disorders: --

    1 disease for MAPK8IP2:    
    About MalaCards
    ameloblastic carcinoma


    Find genes that share disorders with MAPK8IP2           About GenesLikeMe


    Export disorders for MAPK8IP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK8IP2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with MAPK8IP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The JIP group of mitogen-activated protein kinase scaffold proteins. (PubMed id 10490659)1, 2, 3, 9 Yasuda J.... Davis R.J. (Mol. Cell. Biol. 1999)
    2. cDNA cloning and mapping of a novel islet-brain/JNK interacting protein. (PubMed id 10756100)1, 2, 9 Negri S.... Bonny C. (Genomics 2000)
    3. Fibroblast growth factor homologous factors are intracellular signaling proteins. (PubMed id 11378392)1, 2, 9 Schoorlemmer J. and Goldfarb M. (Curr. Biol. 2001)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (Genome Res. 2003)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    7. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (Genome Res. 1997)
    8. Cerebellar and posterior fossa malformations in patients with autism-associated chromosome 22q13 terminal deletion. (PubMed id 23225497)1 Aldinger K.A....Dobyns W.B. (Am. J. Med. Genet. A 2013)
    9. Evaluation of PKM2 and MAPK8IP2 Polymorphism in Ameloblastic Carcinoma: A Retrospective Quantitative Study. (PubMed id 24551779)1 Khodayari A....Aghabozorg Afjeh S. (Int J Mol Cell Med 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23542 HGNC: 6883 AceView: MAPK8IP2 Ensembl:ENSG00000008735 euGenes: HUgn23542
    ECgene: MAPK8IP2 Kegg: 23542 H-InvDB: MAPK8IP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAPK8IP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPK8IP2 gene:
    Search GeneIP for patents involving MAPK8IP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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