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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAPK8IP1 Gene

protein-coding GIFtS: 64
GCID: GC11P045908

mitogen-activated protein kinase 8 interacting protein 1

(Previous symbol: PRKM8IP)

Explore 18 diseases affiliated with
MAPK8IP1 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase 8 Interacting Protein 1¹ ²		IB-1² ³
IB1¹ ² ³ ⁵		JNK MAP Kinase Scaffold Protein 1² ³
JIP-1¹ ² ³		JNK-Interacting Protein 1² ³
JIP1¹ ² ³		C-Jun-Amino-Terminal Kinase-Interacting Protein 1²
PRKM8IP¹ ² ³		PRKM8 Interacting Protein²
Islet-Brain 1² ³		Mitogen-Activated Protein Kinase 8-Interacting Protein 1³

External Ids:	HGNC: 6882¹	Entrez Gene: 9479²	Ensembl: ENSG00000121653⁷	OMIM: 604641⁵	UniProtKB: Q9UQF2³

Export aliases for MAPK8IP1 gene to outside databases

Previous GC identifers: GC11P047691 GC11P046596 GC11P045938 GC11P045871 GC11P045863 GC11P045614

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPK8IP1:

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein

known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated

activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in

pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2.

RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta

cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene

for type 2 diabetes. (provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: JIP1_HUMAN, Q9UQF2

Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by

aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK

activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by

retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific

reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a

role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport,

through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an

anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response

Gene Wiki entry for MAPK8IP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAPK8IP1 gene promoter:
ER-alpha Pbx1a p53 GATA-3 NRSF form 1 STAT5A LCR-F1 NRSF form 2 COMP1 ARP-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAPK8IP1 promoter sequence

Search SABiosciences Chromatin IP Primers for MAPK8IP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK8IP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2

MAPK8IP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK8IP1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P045908: view genomic region (about GC identifiers)

Start:	45,907,202 bp from pter	End:	45,928,016 bp from pter
Size:	20,815 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: JIP1_HUMAN, Q9UQF2 (See protein sequence)

Recommended Name: C-Jun-amino-terminal kinase-interacting protein 1

Size: 711 amino acids; 77524 Da

Subunit: Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely,

MAPK8, MAPK9, MAPK10, MAPKK7, MLK2, MLK3, MAP3K12 and MAP3K13. Also binds the proline-rich domain-containing splice

variant of apolipoprotein E receptor 2 (ApoER2). Interacts, via the PID domain, with ARHGEF28. Binds the cytoplasmic

tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of KNS2, then the pre-assembled MAPK8IP1

scaffolding complexes are transported as a cargo of kinesin, to the required subcellular location. Interacts with the

cytoplasmic domain of APP. Interacts with DCLK2 (By similarity). Interacts with MAP3K7. Interacts with isoform 1 and

isoform 2 of VRK2

Subcellular location: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Nucleus (By

similarity). Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections.

Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells,

detected in both the cytoplasm and nucleus (By similarity)

Miscellaneous: A chemically synthesized cell-permeable peptide of the minimal inhibitory domain decreases brain lesions

in both transient and permanent ischemia. The level of protection is still high when administered 6 or 12 hours after

ischemia

6/13 PDB 3D structures from and Proteopedia for MAPK8IP1 (see all 13):

2G01 (3D)

2GMX (3D)

2H96 (3D)

3OXI (3D)

3PTG (3D)

3VUD (3D)

Secondary accessions: D3DQP4 O43407

Explore the universe of human proteins at neXtProt for MAPK8IP1: NX_Q9UQF2

Post-translational modifications:

Phosphorylated by MAPK8, MAPK9 and MAPK10. Phosphorylation on Thr-103 is also necessary for the dissociation and

activation of MAP3K12. Phosphorylated by isoform 1 and isoform 2 of VRK2. Hyperphosphorylated during mitosis following

activation of stress-activated and MAP kinases¹

Ubiquitinated. Two preliminary events are required to prime for ubiquitination; phosphorylation and an increased in

intracellular calcium concentration. Then, the calcium influx initiates ubiquitination and degradation by the

ubiquitin-proteasome pathway¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UQF2

MAPK8IP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005447.1

ENSEMBL proteins:

ENSP00000241014 ENSP00000378991

Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MAPK8IP1 OriGene Custom Protein Services for MAPK8IP1
	GenScript Custom Purified and Recombinant Proteins Services for MAPK8IP1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAPK8IP1

Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	10574993
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005829	cytosol	IEA	--

MAPK8IP1 for ontologies About GeneDecksing

MAPK8IP1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for MAPK8IP1 (JIP1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for MAPK8IP1
	GenScript Superior Antibodies for MAPK8IP1
	Search for Antibodies for MAPK8IP1 at Abcam
	Uscn Antibodies for MAPK8IP1
	ThermoFisher Antibody for MAPK8IP1

Assay Products for MAPK8IP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MAPK8IP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MAPK8IP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAPK8IP1 for domains About GeneDecksing

3 InterPro domains/families:

IPR001452 SH3_domain

IPR011993 PH_like_dom

IPR006020 PTyr_interaction_dom

Graphical View of Domain Structure for InterPro Entry Q9UQF2

ProtoNet protein and cluster: Q9UQF2

2 Blocks protein families:

IPB001452 SH3 domain signature

IPB006020 Phosphotyrosine interaction domain

UniProtKB/Swiss-Prot: JIP1_HUMAN, Q9UQF2

Domain: The destruction boxes (D-box) may act as recognition signals for degradation via the ubiquitin-proteasome

pathway

Domain: A minimal inhibitory domain prevents pancreatic beta cell apoptosis in vitro, and prevents activation of c-jun

by MAPK8, MAPK9 and MAPK10

Domain: The SH3 domain mediates homodimerization (By similarity)

Similarity: Belongs to the JIP scaffold family

Similarity: Contains 1 PID domain

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: