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Aliases for MAPK8IP1 Gene

Aliases for MAPK8IP1 Gene

  • Mitogen-Activated Protein Kinase 8 Interacting Protein 1 2 3 5
  • JNK MAP Kinase Scaffold Protein 1 3 4
  • JNK-Interacting Protein 1 3 4
  • Islet-Brain 1 3 4
  • PRKM8IP 3 4
  • JIP-1 3 4
  • IB-1 3 4
  • JIP1 3 4
  • IB1 3 4
  • Mitogen-Activated Protein Kinase 8-Interacting Protein 1 4
  • PRKM8 Interacting Protein 3

External Ids for MAPK8IP1 Gene

Previous HGNC Symbols for MAPK8IP1 Gene

  • PRKM8IP

Previous GeneCards Identifiers for MAPK8IP1 Gene

  • GC11P047691
  • GC11P046596
  • GC11P045938
  • GC11P045871
  • GC11P045863
  • GC11P045614

Summaries for MAPK8IP1 Gene

Entrez Gene Summary for MAPK8IP1 Gene

  • This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

GeneCards Summary for MAPK8IP1 Gene

MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1) is a Protein Coding gene. Diseases associated with MAPK8IP1 include diabetes mellitus, noninsulin-dependent and cervix small cell carcinoma. Among its related pathways are ERK Signaling and Akt Signaling. GO annotations related to this gene include identical protein binding and kinesin binding. An important paralog of this gene is MAPK8IP2.

UniProtKB/Swiss-Prot for MAPK8IP1 Gene

  • The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.

Gene Wiki entry for MAPK8IP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK8IP1 Gene

Genomics for MAPK8IP1 Gene

Regulatory Elements for MAPK8IP1 Gene

Promoters for MAPK8IP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAPK8IP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAPK8IP1 Gene

Chromosome:
11
Start:
45,885,496 bp from pter
End:
45,906,465 bp from pter
Size:
20,970 bases
Orientation:
Plus strand

Genomic View for MAPK8IP1 Gene

Genes around MAPK8IP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK8IP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK8IP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK8IP1 Gene

Proteins for MAPK8IP1 Gene

  • Protein details for MAPK8IP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQF2-JIP1_HUMAN
    Recommended name:
    C-Jun-amino-terminal kinase-interacting protein 1
    Protein Accession:
    Q9UQF2
    Secondary Accessions:
    • D3DQP4
    • O43407

    Protein attributes for MAPK8IP1 Gene

    Size:
    711 amino acids
    Molecular mass:
    77524 Da
    Quaternary structure:
    • Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely, MAPK8, MAPK9, MAPK10, MAPKK7, MLK2, MLK3, MAP3K12 and MAP3K13. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2). Interacts, via the PID domain, with ARHGEF28. Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of KNS2, then the pre-assembled MAPK8IP1 scaffolding complexes are transported as a cargo of kinesin, to the required subcellular location. Interacts with the cytoplasmic domain of APP. Interacts with DCLK2 (By similarity). Interacts with MAP3K7. Interacts with isoform 1 and isoform 2 of VRK2.
    Miscellaneous:
    • A chemically synthesized cell-permeable peptide of the minimal inhibitory domain decreases brain lesions in both transient and permanent ischemia. The level of protection is still high when administered 6 or 12 hours after ischemia.

    Three dimensional structures from OCA and Proteopedia for MAPK8IP1 Gene

neXtProt entry for MAPK8IP1 Gene

Proteomics data for MAPK8IP1 Gene at MOPED

Post-translational modifications for MAPK8IP1 Gene

  • Phosphorylated by MAPK8, MAPK9 and MAPK10. Phosphorylation on Thr-103 is also necessary for the dissociation and activation of MAP3K12. Phosphorylated by isoform 1 and isoform 2 of VRK2. Hyperphosphorylated during mitosis following activation of stress-activated and MAP kinases.
  • Ubiquitinated. Two preliminary events are required to prime for ubiquitination; phosphorylation and an increased in intracellular calcium concentration. Then, the calcium influx initiates ubiquitination and degradation by the ubiquitin-proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK8IP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MAPK8IP1 Gene

Domains & Families for MAPK8IP1 Gene

Protein Domains for MAPK8IP1 Gene

Suggested Antigen Peptide Sequences for MAPK8IP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQF2

UniProtKB/Swiss-Prot:

JIP1_HUMAN :
  • The destruction boxes (D-box) may act as recognition signals for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the JIP scaffold family.
Domain:
  • The destruction boxes (D-box) may act as recognition signals for degradation via the ubiquitin-proteasome pathway.
  • A minimal inhibitory domain prevents pancreatic beta cell apoptosis in vitro, and prevents activation of c-jun by MAPK8, MAPK9 and MAPK10.
  • The SH3 domain mediates homodimerization.
  • Contains 1 PID domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the JIP scaffold family.
genes like me logo Genes that share domains with MAPK8IP1: view

No data available for Gene Families for MAPK8IP1 Gene

Function for MAPK8IP1 Gene

Molecular function for MAPK8IP1 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase 8 interacting protein,regulator of the stress activated protein kinase (MAPK8),also described as islet-brain 1,abundantly expressed in brain and in B cells of pancreas,regulator of glucose transporter GLUT2 gene expression
UniProtKB/Swiss-Prot Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.

Gene Ontology (GO) - Molecular Function for MAPK8IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 9933567
GO:0005078 MAP-kinase scaffold activity IEA,IPI 11238452
GO:0008432 JUN kinase binding IEA --
genes like me logo Genes that share ontologies with MAPK8IP1: view
genes like me logo Genes that share phenotypes with MAPK8IP1: view

Animal Models for MAPK8IP1 Gene

MGI Knock Outs for MAPK8IP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPK8IP1

CRISPR Products

miRNA for MAPK8IP1 Gene

miRTarBase miRNAs that target MAPK8IP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK8IP1 Gene

Localization for MAPK8IP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK8IP1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK8IP1 Gene COMPARTMENTS Subcellular localization image for MAPK8IP1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytosol 4
cytoskeleton 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAPK8IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0030425 dendrite IEA --
GO:0044294 dendritic growth cone IEA --
GO:0044302 dentate gyrus mossy fiber IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with MAPK8IP1: view

Pathways & Interactions for MAPK8IP1 Gene

genes like me logo Genes that share pathways with MAPK8IP1: view

Pathways by source for MAPK8IP1 Gene

2 BioSystems pathways for MAPK8IP1 Gene
1 KEGG pathway for MAPK8IP1 Gene

SIGNOR curated interactions for MAPK8IP1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAPK8IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0043508 negative regulation of JUN kinase activity IEA --
genes like me logo Genes that share ontologies with MAPK8IP1: view

Drugs & Compounds for MAPK8IP1 Gene

(11) Drugs for MAPK8IP1 Gene - From: Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One Experimental Pharma Target 0
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE Experimental Pharma Target 0
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE Experimental Pharma Target 0
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE Experimental Pharma Target 0
calcium Nutra 0

(2) Additional Compounds for MAPK8IP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAPK8IP1: view

Transcripts for MAPK8IP1 Gene

mRNA/cDNA for MAPK8IP1 Gene

Unigene Clusters for MAPK8IP1 Gene

Mitogen-activated protein kinase 8 interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8IP1 Gene

No ASD Table

Relevant External Links for MAPK8IP1 Gene

GeneLoc Exon Structure for
MAPK8IP1
ECgene alternative splicing isoforms for
MAPK8IP1

Expression for MAPK8IP1 Gene

mRNA expression in normal human tissues for MAPK8IP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK8IP1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.1), Brain - Hippocampus (x4.2), and Nerve - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for MAPK8IP1 Gene

This gene is overexpressed in CD8 Tcells (40.2), Brain (16.0), and Tlymphocyte (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAPK8IP1 Gene



SOURCE GeneReport for Unigene cluster for MAPK8IP1 Gene Hs.234249

mRNA Expression by UniProt/SwissProt for MAPK8IP1 Gene

Q9UQF2-JIP1_HUMAN
Tissue specificity: Highly expressed in brain. Expressed in neurons, localizing to neurite tips in differentiating cells. Also expressed in the pancreas, testis and prostate. Low levels in heart, ovary and small intestine. Decreased levels in pancreatic beta cells sensitize cells to IL-1-beta-induced apoptosis.
genes like me logo Genes that share expression patterns with MAPK8IP1: view

Protein tissue co-expression partners for MAPK8IP1 Gene

Primer Products

In Situ Assay Products

Orthologs for MAPK8IP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK8IP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK8IP1 36
  • 100 (a)
OneToOne
MAPK8IP1 35
  • 99.39 (n)
  • 99.72 (a)
cow
(Bos Taurus)
Mammalia MAPK8IP1 36
  • 95 (a)
OneToOne
MAPK8IP1 35
  • 90.79 (n)
  • 95.06 (a)
dog
(Canis familiaris)
Mammalia MAPK8IP1 35
  • 89.68 (n)
  • 94.34 (a)
MAPK8IP1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk8ip1 36
  • 93 (a)
OneToOne
Mapk8ip1 16
Mapk8ip1 35
  • 87.96 (n)
  • 93.34 (a)
oppossum
(Monodelphis domestica)
Mammalia MAPK8IP1 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk8ip1 35
  • 87.83 (n)
  • 93.62 (a)
chicken
(Gallus gallus)
Aves MAPK8IP1 35
  • 79.25 (n)
  • 81.35 (a)
MAPK8IP1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK8IP1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk8ip1 35
  • 68.37 (n)
  • 69.81 (a)
zebrafish
(Danio rerio)
Actinopterygii mapk8ip1 36
  • 44 (a)
OneToMany
MAPK8IP1 (1 of 2) 36
  • 50 (a)
OneToMany
LOC100333948 35
  • 62.06 (n)
  • 58.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aplip1 37
  • 43 (a)
Aplip1 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea jip-1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for MAPK8IP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK8IP1 Gene

ENSEMBL:
Gene Tree for MAPK8IP1 (if available)
TreeFam:
Gene Tree for MAPK8IP1 (if available)

Paralogs for MAPK8IP1 Gene

Paralogs for MAPK8IP1 Gene

(1) SIMAP similar genes for MAPK8IP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MAPK8IP1 Gene

genes like me logo Genes that share paralogs with MAPK8IP1: view

Variants for MAPK8IP1 Gene

Sequence variations from dbSNP and Humsavar for MAPK8IP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_012243 Diabetes mellitus, non-insulin-dependent (NIDDM)
rs34420676 - 45,902,732(-) GCCCT(A/G)CCGTG reference, missense
rs12295161 - 45,902,825(+) GTGGC(A/G)GGGGA reference, missense
rs1533614 -- 45,892,101(-) TACGG(A/G)GGTCA intron-variant
rs1467227 -- 45,892,970(-) GCCCT(C/T)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK8IP1 Gene

Variant ID Type Subtype PubMed ID
nsv897314 CNV Loss 21882294
nsv516442 CNV Loss 19592680
esv268491 CNV Insertion 20981092
esv272305 CNV Insertion 20981092

Variation tolerance for MAPK8IP1 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK8IP1 Gene

HapMap Linkage Disequilibrium report
MAPK8IP1
Human Gene Mutation Database (HGMD)
MAPK8IP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK8IP1 Gene

Disorders for MAPK8IP1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for MAPK8IP1 Gene - From: OMIM, ClinVar, Swiss-Prot, and DISEASES

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
cervix small cell carcinoma
  • small cell carcinoma of the cervix
sarcomatoid squamous cell skin carcinoma
  • spindle cell squamous cell carcinoma
hemometra
  • hematometra
fallopian tube adenocarcinoma
  • adenocarcinoma of the fallopian tube
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

JIP1_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:10700186}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Relevant External Links for MAPK8IP1

Genetic Association Database (GAD)
MAPK8IP1
Human Genome Epidemiology (HuGE) Navigator
MAPK8IP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK8IP1
genes like me logo Genes that share disorders with MAPK8IP1: view

No data available for Genatlas for MAPK8IP1 Gene

Publications for MAPK8IP1 Gene

  1. The gene, MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. (PMID: 10700186) Waeber G. … Froguel P. (Nat. Genet. 2000) 3 4 23 67
  2. Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes. (PMID: 19616077) Beeler N. … Abderrahmani A. (Brain Res. Bull. 2009) 3 23
  3. SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase. (PMID: 18055217) Miao T. … Richardson P.M. (Mol. Cell. Neurosci. 2008) 3 23
  4. Two binding partners cooperate to activate the molecular motor Kinesin-1. (PMID: 17200414) Blasius T.L. … Verhey K.J. (J. Cell Biol. 2007) 3 23
  5. The JNK interacting protein JIP-1 and insulin like growth factor II genes are co-expressed in human embryonic tumours. (PMID: 15868948) EngstrAPm W. … Grip S. (Anticancer Res. 2005) 3 23

Products for MAPK8IP1 Gene

Sources for MAPK8IP1 Gene

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