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MAPK8IP1 Gene

protein-coding   GIFtS: 63
GCID: GC11P045908

Mitogen-Activated Protein Kinase 8 Interacting Protein 1


(Previous symbol: PRKM8IP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 8 Interacting Protein 11 2     JIP12 3
PRKM8IP1 2 3     JNK MAP Kinase Scaffold Protein 12 3
IB12 3 5     JNK-Interacting Protein 12 3
Islet-Brain 12 3     C-Jun-Amino-Terminal Kinase-Interacting Protein 12
IB-12 3     PRKM8 Interacting Protein2
JIP-12 3     Mitogen-Activated Protein Kinase 8-Interacting Protein 13

External Ids:    HGNC: 68821   Entrez Gene: 94792   Ensembl: ENSG000001216537   OMIM: 6046415   UniProtKB: Q9UQF23   

Export aliases for MAPK8IP1 gene to outside databases

Previous GC identifers: GC11P047691 GC11P046596 GC11P045938 GC11P045871 GC11P045863 GC11P045614


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK8IP1 Gene:
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein
known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8
mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced
apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose
transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene
in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is
thought to be a susceptibility gene for type 2 diabetes. (provided by RefSeq, May 2011)

GeneCards Summary for MAPK8IP1 Gene:
MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1) is a protein-coding gene. Diseases associated with MAPK8IP1 include diabetes mellitus, noninsulin-dependent, and nephroblastoma. GO annotations related to this gene include protein kinase binding and kinesin binding. An important paralog of this gene is MAPK8IP2.

UniProtKB/Swiss-Prot: JIP1_HUMAN, Q9UQF2
Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK
activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by
retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in
ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell
function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a
regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By
similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or
survival response

Gene Wiki entry for MAPK8IP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK8IP1 gene promoter:
         ER-alpha   Pbx1a   p53   GATA-3   NRSF form 1   STAT5A   LCR-F1   NRSF form 2   COMP1   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPK8IP1 promoter sequence
   Search Chromatin IP Primers for MAPK8IP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK8IP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

MAPK8IP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK8IP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P045908:  view genomic region     (about GC identifiers)

Start:
45,907,047 bp from pter      End:
45,928,016 bp from pter
Size:
20,970 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JIP1_HUMAN, Q9UQF2 (See protein sequence)
Recommended Name: C-Jun-amino-terminal kinase-interacting protein 1  
Size: 711 amino acids; 77524 Da
Subunit: Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely,
MAPK8, MAPK9, MAPK10, MAPKK7, MLK2, MLK3, MAP3K12 and MAP3K13. Also binds the proline-rich domain-containing
splice variant of apolipoprotein E receptor 2 (ApoER2). Interacts, via the PID domain, with ARHGEF28. Binds the
cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of KNS2, then the
pre-assembled MAPK8IP1 scaffolding complexes are transported as a cargo of kinesin, to the required subcellular
location. Interacts with the cytoplasmic domain of APP. Interacts with DCLK2 (By similarity). Interacts with
MAP3K7. Interacts with isoform 1 and isoform 2 of VRK2
Miscellaneous: A chemically synthesized cell-permeable peptide of the minimal inhibitory domain decreases brain
lesions in both transient and permanent ischemia. The level of protection is still high when administered 6 or 12
hours after ischemia
Selected PDB 3D structures from and Proteopedia for MAPK8IP1 (see all 18):
2G01 (3D)        2GMX (3D)        2H96 (3D)        3OXI (3D)        3PTG (3D)        3VUD (3D)    
Secondary accessions: D3DQP4 O43407

Explore the universe of human proteins at neXtProt for MAPK8IP1: NX_Q9UQF2

Explore proteomics data for MAPK8IP1 at MOPED

Post-translational modifications: 

  • Phosphorylated by MAPK8, MAPK9 and MAPK10. Phosphorylation on Thr-103 is also necessary for the dissociation and
    activation of MAP3K12. Phosphorylated by isoform 1 and isoform 2 of VRK2. Hyperphosphorylated during mitosis
    following activation of stress-activated and MAP kinases1
  • Ubiquitinated. Two preliminary events are required to prime for ubiquitination; phosphorylation and an increased
    in intracellular calcium concentration. Then, the calcium influx initiates ubiquitination and degradation by the
    ubiquitin-proteasome pathway1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAPK8IP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005447.1  
    ENSEMBL proteins: 
     ENSP00000241014   ENSP00000378991  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR006020 PTB/PI_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQF2

    ProtoNet protein and cluster: Q9UQF2

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: JIP1_HUMAN, Q9UQF2
    Domain: The destruction boxes (D-box) may act as recognition signals for degradation via the ubiquitin-proteasome
    pathway
    Domain: A minimal inhibitory domain prevents pancreatic beta cell apoptosis in vitro, and prevents activation of
    c-jun by MAPK8, MAPK9 and MAPK10
    Domain: The SH3 domain mediates homodimerization (By similarity)
    Similarity: Belongs to the JIP scaffold family
    Similarity: Contains 1 PID domain
    Similarity: Contains 1 SH3 domain


    MAPK8IP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JIP1_HUMAN, Q9UQF2
    Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by
    aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK
    activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by
    retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in
    ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell
    function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a
    regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By
    similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or
    survival response

         Genatlas biochemistry entry for MAPK8IP1:
    mitogen-activated protein kinase 8 interacting protein,regulator of the stress activated protein kinase
    (MAPK8),also described as islet-brain 1,abundantly expressed in brain and in B cells of pancreas,regulator of
    glucose transporter GLUT2 gene expression

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860protein kinase inhibitor activity TAS9933567
    GO:0005078MAP-kinase scaffold activity IPI11238452
    GO:0005515protein binding IPI11517249
    GO:0008432JUN kinase binding IEA--
    GO:0019894kinesin binding IPI11238452
         
    MAPK8IP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAPK8IP1:
     Decreased viability  Increased cell number in S and 

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mapk8ip1):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     liver/biliary system  mortality/aging  nervous system  reproductive system 

    MAPK8IP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAPK8IP1: Mapk8ip1tm1Rjd Mapk8ip1tm1Wae Mapk8ip1tm1Plhn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK8IP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK8IP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK8IP1

    miRNA
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    hsa-mir-346 (MIRT004239), hsa-mir-191-3p (MIRT042394)

    Block miRNA regulation of human, mouse, rat MAPK8IP1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate MAPK8IP1:
    hsa-miR-633 hsa-miR-656 hsa-miR-338-5p hsa-miR-183 hsa-miR-3670
    SwitchGear 3'UTR luciferase reporter plasmidMAPK8IP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAPK8IP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK8IP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JIP1_HUMAN, Q9UQF2: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Nucleus (By
    similarity). Endoplasmic reticulum membrane. Mitochondrion membrane. Note=Accumulates in cell surface
    projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In
    insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    cytosol3
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA10574993
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005829cytosol IEA--
    GO:0016020membrane ----

    MAPK8IP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK8IP1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Akt Signaling
    Akt Signaling0.60
    2ERK Signaling
    MAPK Signaling0.58
    3TGF-Beta Pathway
    JNK Pathway0.51
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    5Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK8IP1
        MAPK Signaling
    Reelin Pathway (Cajal-Retzius cells)
    JNK Pathway
    Akt Signaling

    2 BioSystems Pathways for MAPK8IP1
        Wnt Signaling Pathway NetPath
    Reelin signaling pathway


    1 Kegg Pathway  (Kegg details for MAPK8IP1):
        MAPK signaling pathway


    MAPK8IP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAPK8IP1
    Interactions:

        GeneGlobe Interaction Network for MAPK8IP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK8IP1 (Q9UQF21, 2, 3 ENSP000002410144) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-78404,EBI-641062 MINT-74574 MINT-74575 MINT-74573 I2D: score=2 STRING: ENSP00000269571
    MAP2K7O147331, 2, 3, ENSP000003810664EBI-78404,EBI-492605 MINT-6629296 I2D: score=5 STRING: ENSP00000381066
    MAP3K7O433181, 2, 3, ENSP000003583354EBI-78404,EBI-358684 MINT-6629291 I2D: score=3 STRING: ENSP00000358335
    APPP050672, 3, ENSP000002849814MINT-14545 MINT-14546 MINT-14544 MINT-14547 I2D: score=8 STRING: ENSP00000284981
    RECQL5O947622, 3MINT-63239 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007165signal transduction ----
    GO:0007258JUN phosphorylation IEA--
    GO:0009967positive regulation of signal transduction IPI11238452
    GO:0016192vesicle-mediated transport ISS--

    MAPK8IP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPK8IP1 (JIP1)

    1 HMDB Compound for MAPK8IP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    4 DrugBank Compounds for MAPK8IP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One-- --target--10592235
    5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE-- --target--10592235
    6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE-- --target--10592235
    N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE-- --target--10592235

    8 Novoseek inferred chemical compound relationships for MAPK8IP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp 600125 64.7 2 15141161 (1), 15880419 (1)
    phosphotyrosine 46.9 2 10574993 (1), 10098834 (1)
    threonine 25.9 1 12783873 (1)
    leucine 18.1 1 14699111 (1)
    atp 10.8 1 18269248 (1)
    serine 10.2 1 12783873 (1)
    nitric oxide 0 1 10748095 (1)
    glucose 0 8 15998799 (2), 15911620 (2), 10700186 (1)



    MAPK8IP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAPK8IP1 gene: 
    NM_005456.3  

    Unigene Cluster for MAPK8IP1:

    Mitogen-activated protein kinase 8 interacting protein 1
    Hs.234249  [show with all ESTs]
    Unigene Representative Sequence: NM_005456
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000241014(uc001nbr.3) ENST00000395629(uc010rgp.1) ENST00000497090

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      QuantiTect SYBR Green Assays in human, mouse, rat MAPK8IP1
      QuantiFast Probe-based Assays in human, mouse, rat MAPK8IP1

    Additional mRNA sequence: 

    AB209720.1 AF007134.1 AF074091.1 AK293637.1 AK295942.1 BC035920.1 BC068470.1 

    8 DOTS entries:

    DT.455293  DT.86838644  DT.120742775  DT.101982333  DT.95277919  DT.120742776  DT.121008669  DT.95147259 

    Selected AceView cDNA sequences (see all 164):

    BQ639533 BM129304 CD674131 BM727045 Z45164 BF792532 CD109224 BE797338 
    CD242589 BC035920 AU142817 AF074091 BM702487 AI198984 BX098115 BI754774 
    NM_005456 CB156417 AA323331 BM129776 CR605837 T31232 AW205523 AF007134 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPK8IP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCTGTG
    MAPK8IP1 Expression
    About this image


    MAPK8IP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Eye (Sensory Organs)
             Retina
    MAPK8IP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK8IP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.234249

    UniProtKB/Swiss-Prot: JIP1_HUMAN, Q9UQF2
    Tissue specificity: Highly expressed in brain. Expressed in neurons, localizing to neurite tips in differentiating
    cells. Also expressed in the pancreas, testis and prostate. Low levels in heart, ovary and small intestine.
    Decreased levels in pancreatic beta cells sensitize cells to IL-1-beta-induced apoptosis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAPK8IP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk8ip11 , 5 mitogen-activated protein kinase 8 interacting protein more1, 5 87.96(n)1
    93.34(a)1
      2 (50.99 cM)5
    190991  NM_011162.51  NP_035292.21 
     923836765 
    chicken
    (Gallus gallus)
    Aves MAPK8IP11 mitogen-activated protein kinase 8 interacting protein more 79.25(n)
    81.35(a)
      423202  XM_421126.4  XP_421126.4 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK8IP16
    mitogen-activated protein kinase 8 interacting pro...
    71(a)
    1 ↔ 1
    1(47840635-47898899)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mapk8ip11 mitogen-activated protein kinase 8 interacting protein more 68.37(n)
    69.81(a)
      100496373  XM_002934093.2  XP_002934139.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003339481 c-Jun-amino-terminal kinase-interacting protein 1-like 62.06(n)
    58.41(a)
      100333948  XM_005172384.1  XP_005172441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aplip13 regulation of JNK cascade kinesin
    binding
    43(a)   61F3   --
    worm
    (Caenorhabditis elegans)
    Secernentea jip-16
    Protein JIP-1, isoform a (jip-1) mRNA, complete cd...
    12(a)
    1 → many
    II(1326995-1350136) WBGene00002176


    ENSEMBL Gene Tree for MAPK8IP1 (if available)
    TreeFam Gene Tree for MAPK8IP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK8IP1 gene
    MAPK8IP22  
    1 SIMAP similar gene for MAPK8IP1 using alignment to 3 protein entries:     JIP1_HUMAN (see all proteins):
    MAPK8IP2

    MAPK8IP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MAPK8IP1
    PGOHUM00000237091 PGOHUM00000237414


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPK8IP1 (see all 484)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0122434
    Diabetes mellitus, non-insulin-dependent (NIDDM)4--see VAR_0122432 S N mis40--------
    rs759732691,2
    C,F--45612160(+) CCTCTC/TTGTGC 1 -- us2k11Minor allele frequency- T:0.12EA 120
    rs559237411,2
    C,F--45612337(+) GTCTCA/GTTCTT 1 -- us2k16Minor allele frequency- G:0.17WA NA CSA EA 364
    rs1471735061,2
    C--45612404(+) TCCTTC/TTTGCC 1 -- us2k10--------
    rs38248721,2
    C,F,A,H--45612462(-) CAAAGT/GTATCT 1 -- us2k126Minor allele frequency- G:0.46NS EA NA WA CSA 2702
    rs1931673591,2
    --45612475(+) CTTGAA/GCAAAA 1 -- us2k10--------
    rs1844144981,2
    --45612522(+) CTGACC/TTGCTA 1 -- us2k10--------
    rs1874361531,2
    --45612551(+) GGCAGA/GTCTAC 1 -- us2k10--------
    rs578678431,2
    C,F--45612670(+) GATCAC/TGAAAG 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs1147517761,2
    C,F--45612881(+) AAATAG/AGACTC 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for MAPK8IP1 (45907047 - 45928016 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MAPK8IP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272305CNV Insertion20981092
    esv268491CNV Insertion20981092
    nsv897314CNV Loss21882294
    nsv516442CNV Loss19592680

    Human Gene Mutation Database (HGMD): MAPK8IP1
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604641   
    OMIM disorders: 125853  
    UniProtKB/Swiss-Prot: JIP1_HUMAN, Q9UQF2
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose
    homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese
    body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance,
    hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes,
    kidneys, nerves, and blood vessels. Note=The disease may be caused by mutations affecting the gene represented in
    this entry

  • Selected diseases for MAPK8IP1 (see all 23):    
    About MalaCards
    diabetes mellitus, noninsulin-dependent    nephroblastoma    insulin resistance    vaccinia
    pancreatitis    parkinson's disease    diabetes mellitus    alzheimer's disease
    ischemia    dementia    prostate cancer    hypoxia
    neuroblastoma    obesity    prostatitis    cerebritis
    thyroiditis    pancreatic cancer    hiv-1    neuronitis


    MAPK8IP1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for MAPK8IP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 32.6 1 19616077 (1)
    parkinson disease 4.15 1 11504916 (1)
    ischemia 0 2 15836924 (2)
    prostate cancer 0 2 15138488 (1)

    Genetic Association Database (GAD): MAPK8IP1
    Human Genome Epidemiology (HuGE) Navigator: MAPK8IP1 (2 documents)

    Export disorders for MAPK8IP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK8IP1 gene, integrated from 10 sources (see all 109):
    (articles sorted by number of sources associating them with MAPK8IP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene, MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. (PubMed id 10700186)1, 2, 9 Waeber G.... Froguel P. (Nat. Genet. 2000)
    2. Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/C-jun-amino-terminal kinase interacting protein-1 (JIP-1) gene. (PubMed id 9933567)1, 2, 9 Mooser V.... Waeber G. (Genomics 1999)
    3. Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation. (PubMed id 12756254)1, 2, 9 Nihalani D.... Holzman L.B. (J. Biol. Chem. 2003)
    4. Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. (PubMed id 10574993)1, 2, 9 Meyer D.... Margolis B. (J. Biol. Chem. 1999)
    5. Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease. (PubMed id 12740599)1, 4, 9 Helbecque N....Abderrhamani A. (Mol. Psychiatry 2003)
    6. Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. (PubMed id 11726277)1, 2, 9 Ikeda A.... Kawasaki T. (J. Biochem. 2001)
    7. Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1. (PubMed id 14507925)1, 2, 9 Allaman-Pillet N.... Bonny C. (J. Biol. Chem. 2003)
    8. Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. (PubMed id 18286207)1, 2 Blanco S.... Lazo P.A. (PLoS ONE 2008)
    9. Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. (PubMed id 17709393)1, 2 Blanco S.... Lazo P.A. (Mol. Cell. Biol. 2007)
    10. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. (PubMed id 12937412)1, 2 Borsello T.... Bonny C. (Nat. Med. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9479 HGNC: 6882 AceView: MAPK8IP1 Ensembl:ENSG00000121653 euGenes: HUgn9479
    ECgene: MAPK8IP1 Kegg: 9479 H-InvDB: MAPK8IP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAPK8IP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPK8IP1 gene:
    Search GeneIP for patents involving MAPK8IP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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