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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK8 Gene

protein-coding   GIFtS: 73
GCID: GC10P049514

mitogen-activated protein kinase 8


(Previous symbol: PRKM8)
 Explore 191 diseases affiliated with
MAPK8 via
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Biological research products
for MAPK8    

Aliases
for MAPK8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase 81 2     JNK1A22
JNK11 2 3 5     JNK21B1/22
PRKM81 2 3 5     JUN N-Terminal Kinase2
SAPK11 2 3 5     Mitogen-Activated Protein Kinase 8 Isoform JNK1 Alpha12
JNK1 2     Mitogen-Activated Protein Kinase 8 Isoform JNK1 Beta22
Stress-Activated Protein Kinase 1c2 3     Stress-Activated Protein Kinase 12
JNK-462 3     SAPK1C3
SAPK1c2 3     MAPK 83
C-Jun N-Terminal Kinase 12 3     Stress-Activated Protein Kinase JNK13
MAP Kinase 82 3     EC 2.7.118
EC 2.7.11.243 8     

External Ids:    HGNC: 68811   Entrez Gene: 55992   Ensembl: ENSG000001076437   OMIM: 6011585   UniProtKB: P459833   

Export aliases for MAPK8 gene to outside databases

Previous GC identifers: GC10P048468 GC10P049407 GC10P048954 GC10P049279 GC10P043874


Summaries
for MAPK8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPK8:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and
targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli.
The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced
apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom
c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key
role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding
distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MK08_HUMAN, P45983
Function: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation,
migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or
physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In
this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn,
MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2
and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the
interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates
the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key
regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for
polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by
phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2
phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence
regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through
its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration
from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the
deacetylase SIRT1, ELK1, or the E3 ligase ITCH
Function: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1,
alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation
between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms

summary for MAPK8:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK8


Genomic Views
for MAPK8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK8 gene promoter:
         AP-1   ATF-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAPK8 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.22   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11

MAPK8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P049514:  view genomic region     (about GC identifiers)

Start:
 49,514,698 bp from pter      End:
 49,647,403 bp from pter
Size:
 132,706 bases      Orientation:
 plus strand

Proteins
for MAPK8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MK08_HUMAN, P45983 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 8  
Size: 427 amino acids; 48296 Da
Cofactor: Magnesium
Subunit: Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and
SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and
WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and ARHGEF28 (By similarity). Interacts (phosphorylated form)
with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells (By similarity). Interacts with NFATC4.
Interacts with MECOM; regulates JNK signaling. Interacts with PIN1; this interaction mediates MAPK8 conformational
changes leading to the binding of MAPK8 to its substrates
Subcellular location: Cytoplasm. Nucleus
6/13 PDB 3D structures from and Proteopedia for MAPK8 (see all 13):
1UKH (3D)        1UKI (3D)        2G01 (3D)        2GMX (3D)        2H96 (3D)        2NO3 (3D)    
Secondary accessions: B5BTZ5 B7ZLV4 D3DX88 D3DX92 Q15709 Q15712 Q15713
Alternative splicing: 4 isoforms:  P45983-1   P45983-2   P45983-3   P45983-4   (Contains a phosphoserine at position 377)

Explore the universe of human proteins at neXtProt for MAPK8: NX_P45983

Post-translational modifications:

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by TAOK21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P45983

    • 4/27 DME Specific Peptides for MAPK8 (P45983) (see all 27)
     KELIYKE  ILDFGLA  LDFGLAR  LLSKMLV 

    MAPK8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_002741.1  NP_620634.1  NP_620635.1  NP_620637.1  

    ENSEMBL proteins: 
     ENSP00000387936   ENSP00000393223   ENSP00000363304   ENSP00000397729   ENSP00000363297  
     ENSP00000363294   ENSP00000363291   ENSP00000363289   ENSP00000353483   ENSP00000378974  
    Reactome Protein details: P45983
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAPK8 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MAPK8
    OriGene Purified Proteins (see all 3): MAPK8
    OriGene Protein Over-expression Lysate (see all 5): MAPK8
    OriGene Custom Protein Services for MAPK8 
    GenScript Custom Purified and Recombinant Proteins Services for MAPK8
    Novus Biologicals MAPK8 Proteins
    Novus Biologicals MAPK8 Lysates
    Sino Biological Recombinant Protein for MAPK8
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAPK8

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--


    MAPK8 for ontologies           About GeneDecksing



    MAPK8 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK8
    R&D Systems Antibodies for MAPK8 (JNK1)
    Cell Signaling Technology (CST) Antibodies for MAPK8  (JNK1)
    OriGene Antibodies (see all 7): MAPK8
    OriGene Custom Antibody Services for MAPK8 
    GenScript Superior Antibodies for MAPK8
    Novus Biologicals MAPK8 Antibodies
    Abcam antibodies for MAPK8 
    Uscn Antibodies for MAPK8
    ThermoFisher Antibody for MAPK8

    Assay Products for MAPK8: 
    EMD Millipore Kits and Assays for the Analysis of MAPK8
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for MAPK8 (JNK1)         (see all)
    GenScript Custom Assay Services for MAPK8
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK8 (JNK1)
    Enzo Life Sciences assays for MAPK8
    Uscn ELISAs and CLIAs for MAPK8

    Protein Domains /
    Families
    for MAPK8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPK8 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR008351 MAPK_JNK
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR003527 MAP_kinase_CS

    Graphical View of Domain Structure for InterPro Entry P45983

    ProtoNet protein and cluster: P45983

    2 Blocks protein families:
    IPB003527 MAP kinase
    IPB008351 JNK MAP kinase signature


    UniProtKB/Swiss-Prot: MK08_HUMAN, P45983
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAPK8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MK08_HUMAN, P45983
    Function: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation,
    migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or
    physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In
    this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn,
    MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2
    and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the
    interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates
    the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key
    regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for
    polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by
    phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2
    phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence
    regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through
    its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration
    from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the
    deacetylase SIRT1, ELK1, or the E3 ligase ITCH
    Function: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1,
    alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation
    between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases,
    MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially.
    Inhibited by dual specificity phosphatases, such as DUSP1

         Genatlas biochemistry entry for MAPK8:
    mitogen-activated protein kinase 8,with three alternatively spliced isoforms JNK1,JNK2,JNK3 (MAP kinase),activated by
    UV irradiation and H-RAS,phosphorylating JUN

    Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target MAPK8:
    hsa-mir-214 (MIRT005427)

    OriGene 3'-UTR Clone (see all 4): MAPK8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK8
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK8:
    hsa-miR-3168 hsa-miR-219-2-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK8 (see all 4)
    OriGene shRNA RFP: MAPK8
    OriGene siRNA: MAPK8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPK8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK8 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK8 (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK8 (NM_002750)
    Sino Biological Human cDNA Clone for MAPK8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK8 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAPK8
    Search LifeMap BioReagents cell lines for MAPK8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK8

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IDA14967141
    GO:0004705JUN kinase activity IDA--
    GO:0004707MAP kinase activity ----
    GO:0005515protein binding IPI10856240
    GO:0005524ATP binding IEA--


    MAPK8 for ontologies           About GeneDecksing


    9 GenomeRNAi human phenotypes for MAPK8:
     Decreased Hepatitis C virus re  Decreased focal adhesion (FA)   Increased S DNA content  Increased cell death HMECs cel 
     Increased cell death in breast  Increased circadian period len  Increased mitotic index  Increased telomerase activity 
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Mapk8tm1Flv for MAPK8
         15/21 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Mapk8) (see all 21):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  muscle 

    MAPK8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPK8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/167 super-pathways (see all 167) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2Development HGF signaling pathway
    8/17 pathways (see all 17)
    		Development HGF signaling pathway1.00
    		Development EGFR signaling via PIP30.26
    		Development_HGF signaling pathway0.78
    		Development_EGFR signaling via PIP30.26
    		Development_Neurotrophin family signaling0.45
    		Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR10.24
    		Development Neurotrophin family signaling0.45
    		Apoptosis and survival Anti-apoptotic action of membrane-bound ESR10.24
    3ErbB4 Pathway
    8/10 pathways (see all 10)
    		ErbB4 Pathway1.00
    		LPS Stimulated MAPK Signaling0.36
    		ErbB Family Pathway0.59
    		VEGF Signaling Pathway0.35
    		Prolactin Signaling0.54
    		TREM1 Pathway0.32
    		IL-2 Pathway0.46
    		HMGB1 Pathway0.32
    4TWEAK Pathway
    8/9 pathways (see all 9)
    		TNFR1 Pathway0.53
    		Apoptotic Pathways Triggered By HIV10.37
    		HIV-1 Nef- Negative effector of Fas and TNF-alpha0.42
    		Apoptosis through Death Receptors0.32
    		Apoptosis and survival_TNFR1 signaling pathway0.40
    		TWEAK Signaling Pathway0.31
    		Apoptosis and survival TNFR1 signaling pathway0.40
    		Fas Signaling0.29
    5G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    		G-protein signaling Ras family GTPases in kinase cascades (scheme)1.00
    		Activation of the AP-1 family of transcription factors0.33
    		G-protein signaling_Ras family GTPases in kinase cascades (scheme)1.00
    		Oncostatin M Signaling Pathway0.15
    		Immune response_Oncostatin M signaling via MAPK in human cells0.39
    		Rapid glucocorticoid signaling0.12
    		Immune response Oncostatin M signaling via MAPK in human cells0.39

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/37 EMD Millipore Pathways for MAPK8 (see all 37)
        Cytoskeleton remodeling FAK signaling
    Apoptosis and survival FAS signaling cascades
    Immune response MIF in innate immunity response
    Cytoskeleton remodeling Keratin filaments
    Immune response IL-1 signaling pathway

    4 R&D Systems Pathways for MAPK8
        Wnt Signaling Pathway
    Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways
    TGF-beta Signaling Pathways

    5/114 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK8 (see all 114)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPK8
        MAP Kinase Signaling

    5 Tocris Bioscience Pathways for MAPK8
        Akt Pathway
    Insulin Pathway
    Toll-like Receptor Pathway
    VEGF Pathway
    MAPK Pathway

    5/38 GeneGo (Thomson Reuters) Pathways for MAPK8 (see all 38)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Development Endothelin-1/EDNRA signaling

    5/73 BioSystems Pathways for MAPK8 (see all 73) 
        ErbB signaling pathway
    DNA damage response (only ATM dependent)
    Keap1-Nrf2 Pathway
    Oncostatin M Signaling Pathway
    FAS pathway and Stress induction of HSP regulation

    5/37        Reactome Pathways for MAPK8 (see all 37)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll Like Receptor 3 (TLR3) Cascade
    MyD88-independent cascade
    Intrinsic Pathway for Apoptosis

    3 PharmGKB Pathways for MAPK8
        EGFR Inhibitor Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/27         Kegg Pathways  (Kegg details for MAPK8) (see all 27):
        MAPK signaling pathway
    ErbB signaling pathway
    Protein processing in endoplasmic reticulum
    Wnt signaling pathway
    Osteoclast differentiation


    MAPK8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    180/210 Interacting proteins for MAPK8 (P459831, 2, 3 ENSP000003534834) via UniProtKB, MINT, STRING, and/or I2D (see all 210) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054121, 2, 3, ENSP000003602664EBI-288687,EBI-852823 MINT-7148314 I2D: score=11 STRING: ENSP00000360266
    TP53P046372, 3, ENSP000002693054MINT-61312 I2D: score=5 STRING: ENSP00000269305
    BCL2P104152, 3, ENSP000003296234MINT-56639 I2D: score=4 STRING: ENSP00000329623
    BCL2L1Q078172, 3, ENSP000003025644MINT-56640 I2D: score=4 STRING: ENSP00000302564
    CRKP461082, 3, ENSP000003005744MINT-7103547 I2D: score=4 STRING: ENSP00000300574
    HSPA8P111422, 3, ENSP000002273784MINT-8262319 I2D: score=2 STRING: ENSP00000227378
    PNRC1Q127962, 3, ENSP000003369314MINT-8262330 I2D: score=2 STRING: ENSP00000336931
    SCAND1P570862, 3, ENSP000003019954MINT-8262352 I2D: score=2 STRING: ENSP00000301995
    CRKLP461092, 3, ENSP000003463004MINT-7103692 I2D: score=1 STRING: ENSP00000346300
    PPP2CBP627142, 3, ENSP000002211384MINT-8287126 I2D: score=1 STRING: ENSP00000221138
    ZNF219Q9P2Y42, 3MINT-8262363 I2D: score=2 
    CBLP226812, 3, ENSP000002640334MINT-7103623 MINT-7103648 I2D: score=1 STRING: ENSP00000264033
    PIK3R1P279862, 3, ENSP000002743354MINT-7103616 MINT-7103638 I2D: score=3 STRING: ENSP00000274335
    MAPK8IP1Q9UQF22, 3, ENSP000002410144MINT-6629301 I2D: score=7 STRING: ENSP00000241014
    WWOXQ9NZC72, 3, ENSP000003861614MINT-61313 I2D: score=2 STRING: ENSP00000386161
    PPP2CAP677752, 3, ENSP000004184474MINT-8287100 I2D: score=1 STRING: ENSP00000418447
    FLNBO753692, 3, ENSP000002959564MINT-7288748 I2D: score=1 STRING: ENSP00000295956
    BMPR2Q138732, 3, ENSP000003637084MINT-8262275 I2D: score=2 STRING: ENSP00000363708
    CCDC88CQ9P2192, 3, ENSP000003745074MINT-8262286 I2D: score=2 STRING: ENSP00000374507
    RBM15Q96T372, 3, ENSP000003587994MINT-8262341 I2D: score=2 STRING: ENSP00000358799
    DUSP8Q132022, 3, ENSP000003295394MINT-8262297 I2D: score=2 STRING: ENSP00000329539
    FAM193BQ96PV72, 3, ENSP000004100984MINT-8262308 I2D: score=1 STRING: ENSP00000410098
    MAP2K4P459853, ENSP000002624454I2D: score=5 STRING: ENSP00000262445
    MAP3K7O433183, ENSP000003583354I2D: score=4 STRING: ENSP00000358335
    RELQ048643, ENSP000002950254I2D: score=4 STRING: ENSP00000295025
    CDKN1AP389363, ENSP000002447414I2D: score=3 STRING: ENSP00000244741
    DUSP1P285623, ENSP000002392234I2D: score=3 STRING: ENSP00000239223
    DUSP16Q9BY843, ENSP000002288624I2D: score=3 STRING: ENSP00000228862
    JUNBP172753, ENSP000003033154I2D: score=3 STRING: ENSP00000303315
    JUNDP175353, ENSP000002528184I2D: score=3 STRING: ENSP00000252818
    MAP3K2Q9Y2U53, ENSP000003434634I2D: score=3 STRING: ENSP00000343463
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    PRKDCP785273, ENSP000003134204I2D: score=3 STRING: ENSP00000313420
    DUSP22Q9NRW43, ENSP000003452814I2D: score=2 STRING: ENSP00000345281
    DUSP7Q168293, ENSP000002964834I2D: score=2 STRING: ENSP00000296483
    ELK3P419703, ENSP000002287414I2D: score=2 STRING: ENSP00000228741
    HSF4Q9ULV53, ENSP000002640094I2D: score=2 STRING: ENSP00000264009
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    MAPK3P273613, ENSP000002630254I2D: score=2 STRING: ENSP00000263025
    NFE2Q166213, ENSP000003124364I2D: score=2 STRING: ENSP00000312436
    NR3C1P041503, ENSP000002315094I2D: score=2 STRING: ENSP00000231509
    PRKD1Q151393, ENSP000003335684I2D: score=2 STRING: ENSP00000333568
    SMAD2Q157963, ENSP000002621604I2D: score=2 STRING: ENSP00000262160
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    SPAG9O602713, ENSP000002620134I2D: score=2 STRING: ENSP00000262013
    SPIBQ018923, ENSP000002706324I2D: score=2 STRING: ENSP00000270632
    XRCC6P129563, ENSP000003522574I2D: score=2 STRING: ENSP00000352257
    ARHGDIAP525653, ENSP000002693214I2D: score=1 STRING: ENSP00000269321
    BADQ929343, ENSP000003091034I2D: score=1 STRING: ENSP00000309103
    BCAR1P569453, ENSP000001623304I2D: score=1 STRING: ENSP00000162330
    BIDP559573, ENSP000003188224I2D: score=1 STRING: ENSP00000318822
    CASP10Q928513, ENSP000002861864I2D: score=1 STRING: ENSP00000286186
    CASP8Q147903, ENSP000003512734I2D: score=1 STRING: ENSP00000351273
    CDKN2AQ8N7263I2D: score=2 I2D: score=1 
    EEF2KO004183, ENSP000002630264I2D: score=1 STRING: ENSP00000263026
    FADDQ131583, ENSP000003018384I2D: score=1 STRING: ENSP00000301838
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    MAP1BP468213, ENSP000002967554I2D: score=1 STRING: ENSP00000296755
    MAP3K1Q132333, ENSP000003824234I2D: score=1 STRING: ENSP00000382423
    NFATC4Q149343, ENSP000003889104I2D: score=1 STRING: ENSP00000388910
    PDPK1O155303, ENSP000003442204I2D: score=1 STRING: ENSP00000344220
    RHOAP615863, ENSP000004001754I2D: score=1 STRING: ENSP00000400175
    RPS6KB1P234433, ENSP000002255774I2D: score=1 STRING: ENSP00000225577
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    SPI1P179473, ENSP000002271634I2D: score=1 STRING: ENSP00000227163
    TAB1Q157503, ENSP000002161604I2D: score=1 STRING: ENSP00000216160
    TFCP2Q128003, ENSP000002579154I2D: score=1 STRING: ENSP00000257915
    TNFRSF10BO147633, ENSP000002764314I2D: score=1 STRING: ENSP00000276431
    TNFRSF1AP194383, ENSP000001627494I2D: score=1 STRING: ENSP00000162749
    ATF2P153363, ENSP000002641104I2D: score=3 STRING: ENSP00000264110
    IRS1P355683, ENSP000003048954I2D: score=3 STRING: ENSP00000304895
    MAP2K7O147333, ENSP000003810664I2D: score=3 STRING: ENSP00000381066
    MAPK8IP3Q9UPT63, ENSP000002508944I2D: score=3 STRING: ENSP00000250894
    DUSP10Q9Y6W63, ENSP000003558664I2D: score=4 STRING: ENSP00000355866
    DUSP4Q131153, ENSP000002401004I2D: score=3 STRING: ENSP00000240100
    GSTP1P092113, ENSP000003816074I2D: score=3 STRING: ENSP00000381607
    HRASP011123, ENSP000003098454I2D: score=2 STRING: ENSP00000309845
    KRT8P057873, ENSP000002933084I2D: score=2 STRING: ENSP00000293308
    STAT3P407633, ENSP000002646574I2D: score=2 STRING: ENSP00000264657
    BMFQ96LC93, ENSP000003466974I2D: score=2 STRING: ENSP00000346697
    COPS2P612013, ENSP000002992594I2D: score=2 STRING: ENSP00000299259
    ELK1P194193, ENSP000002471614I2D: score=4 STRING: ENSP00000247161
    IKBKAPO951633, ENSP000003637794I2D: score=4 STRING: ENSP00000363779
    IL27RAQ6UWB13, ENSP000002633794I2D: score=2 STRING: ENSP00000263379
    JDP2Q8WYK23, ENSP000002675694I2D: score=1 STRING: ENSP00000267569
    JKAMPQ9P0553, ENSP000002612474I2D: score=1 STRING: ENSP00000261247
    MAPK14Q165393, ENSP000002297944I2D: score=2 STRING: ENSP00000229794
    NFATC2Q134693, ENSP000003793304I2D: score=1 STRING: ENSP00000379330
    NR4A1P227363, ENSP000002430504I2D: score=1 STRING: ENSP00000243050
    PAX2Q029623, ENSP000003550694I2D: score=2 STRING: ENSP00000355069
    PPARGP372313, ENSP000002878204I2D: score=1 STRING: ENSP00000287820
    PXNP490233, ENSP000002283074I2D: score=2 STRING: ENSP00000228307
    SH2D3AQ9BRG23, ENSP000002459084I2D: score=1 STRING: ENSP00000245908
    TNFSF11O147883, ENSP000002398494I2D: score=1 STRING: ENSP00000239849
    TP73O153503, ENSP000003675454I2D: score=1 STRING: ENSP00000367545
    HDAC9Q9UKV03, ENSP000004086174I2D: score=1 STRING: ENSP00000408617
    MAPK8IP2Q133873, ENSP000003305724I2D: score=2 STRING: ENSP00000330572
    RASSF1Q9NS233, ENSP000003495474I2D: score=1 STRING: ENSP00000349547
    RETP079493, ENSP000003479424I2D: score=1 STRING: ENSP00000347942
    SH3BP5O602393, ENSP000003733014I2D: score=7 STRING: ENSP00000373301
    SHC1P293533, ENSP000004013034I2D: score=1 STRING: ENSP00000401303
    SNCAP378403, ENSP000003383454I2D: score=2 STRING: ENSP00000338345
    SNCGO760703, ENSP000003610874I2D: score=4 STRING: ENSP00000361087
    YWHAZP631043, ENSP000003095034I2D: score=1 STRING: ENSP00000309503
    ETV1P505493, ENSP000003840854I2D: score=1 STRING: ENSP00000384085
    PIAS2O759283, ENSP000003816484I2D: score=1 STRING: ENSP00000381648
    EZRP153113, ENSP000003389344I2D: score=1 STRING: ENSP00000338934
    FASP254453, ENSP000003479794I2D: score=1 STRING: ENSP00000347979
    FASLGP480233, ENSP000003566944I2D: score=1 STRING: ENSP00000356694
    MSNP260383, ENSP000003534084I2D: score=1 STRING: ENSP00000353408
    BCL2L11O435213I2D: score=3 
    GATAD2BQ8WXI93I2D: score=2 
    HSF1Q006133I2D: score=2 
    MAPKBP1O603363I2D: score=2 
    AIMP1Q129043I2D: score=1 
    AKT2P317513I2D: score=1 
    ANO5Q75V663I2D: score=1 
    APPP050673I2D: score=1 
    CASP3P425743I2D: score=1 
    CDKN1CP499183I2D: score=1 
    CEBPAP497153I2D: score=1 
    CTNNB1P352223I2D: score=1 
    ELK4P283243I2D: score=1 
    FHOD1Q9Y6133I2D: score=1 
    GEMIN5Q8TEQ63I2D: score=1 
    GNB2L1P632443I2D: score=1 
    GRIA4P480583I2D: score=1 
    IRAK1P516173I2D: score=1 
    IRF3Q146533I2D: score=1 
    MAPKAP1Q9BPZ73I2D: score=1 
    MCL1Q078203I2D: score=1 
    MYT1Q015383I2D: score=1 
    RARAP102763I2D: score=1 
    SERPINB3P295083I2D: score=1 
    SERPINB4P485943I2D: score=1 
    SYT4Q9H2B23I2D: score=1 
    TRAF6Q9Y4K33I2D: score=1 
    WDR62O433793I2D: score=1 
    ARAFENSP000003662444STRING: ENSP00000366244
    BRAFENSP000002886024STRING: ENSP00000288602
    CARD9ENSP000003607974STRING: ENSP00000360797
    DUSP2ENSP000002889434STRING: ENSP00000288943
    DUSP3ENSP000002260044STRING: ENSP00000226004
    DUSP5ENSP000003585964STRING: ENSP00000358596
    DUSP6ENSP000002794884STRING: ENSP00000279488
    DUSP9ENSP000003458534STRING: ENSP00000345853
    FOSENSP000003062454STRING: ENSP00000306245
    FOSBENSP000002459194STRING: ENSP00000245919
    FOSL1ENSP000003101704STRING: ENSP00000310170
    FOSL2ENSP000002647164STRING: ENSP00000264716
    HSPA2ENSP000002472074STRING: ENSP00000247207
    HSPA6ENSP000003102194STRING: ENSP00000310219
    IRS2ENSP000003650164STRING: ENSP00000365016
    IRS4ENSP000003612024STRING: ENSP00000361202
    MAP2K1ENSP000003024864STRING: ENSP00000302486
    MECOMENSP000004178994STRING: ENSP00000417899
    PGRENSP000003251204STRING: ENSP00000325120
    PRKCQENSP000002631254STRING: ENSP00000263125
    PTPN5ENSP000003513424STRING: ENSP00000351342
    PTPN7ENSP000003562484STRING: ENSP00000356248
    PTPRRENSP000002832284STRING: ENSP00000283228
    RAC2ENSP000002490714STRING: ENSP00000249071
    RAC3ENSP000003042834STRING: ENSP00000304283
    RAP1AENSP000003487864STRING: ENSP00000348786
    RAP1BENSP000002505594STRING: ENSP00000250559
    RIPK2ENSP000002207514STRING: ENSP00000220751
    TAB2ENSP000002863324STRING: ENSP00000286332
    TAB3ENSP000002884224STRING: ENSP00000288422
    TRAF2ENSP000002476684STRING: ENSP00000247668
    CDT1ENSP000003010194STRING: ENSP00000301019
    FZR1ENSP000003785294STRING: ENSP00000378529
    ITCHENSP000003639984STRING: ENSP00000363998
    RB1ENSP000002671634STRING: ENSP00000267163
    CDC25BENSP000002459604STRING: ENSP00000245960
    NCOA3ENSP000003610664STRING: ENSP00000361066
    CPEB1ENSP000004141874STRING: ENSP00000414187
    EIF6ENSP000003635594STRING: ENSP00000363559
    RAD18ENSP000002649264STRING: ENSP00000264926
    VRK2ENSP000003423814STRING: ENSP00000342381
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----


    MAPK8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPK8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK8 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK8:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for MAPK8

    Compounds for MAPK8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS JNK 6oSelective JNK inhibitor[894804-07-0]
    SP 600125Novel and selective JNK inhibitor[129-56-6]
    SU 3327Selective JNK inhibitor[40045-50-9]
    BI 78D3 Selective, competitive JNK inhibitor [883065-90-5]
    AnisomycinProtein synthesis inhibitor[22862-76-6]

    3 HMDB Compounds for MAPK8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    6 DrugBank Compounds for MAPK8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One-- --target--10592235
    2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE-- --target--10592235
    2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide-- --target--10592235
    5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE-- --target--10592235
    6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE-- --target--10592235
    N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE-- --target--10592235

    10/130 Novoseek chemical compound relationships for MAPK8 gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp 600125 97.5 1060 15454338 (4), 17322004 (4), 14766793 (3), 15242986 (3) (see all 99)
    sb 203580 92.2 314 18655782 (4), 18222647 (3), 18718914 (2), 9598985 (2) (see all 99)
    pd 98,059 89.3 240 11164710 (2), 16480952 (2), 17191113 (2), 9603971 (1) (see all 99)
    anisomycin 81.1 110 17699104 (6), 8626428 (3), 12220537 (3), 16672691 (2) (see all 63)
    ly294002 74.7 76 10628325 (2), 16722795 (2), 9878764 (2), 12555073 (2) (see all 57)
    kt 7515 74.2 7 9631443 (2), 12376548 (1), 11279271 (1), 11756493 (1) (see all 6)
    n acetylcysteine 74 137 19176594 (3), 8824287 (2), 18038907 (2), 18679584 (2) (see all 84)
    phosphatidylinositol 72.9 135 9315636 (4), 10050043 (3), 16000309 (3), 17008315 (3) (see all 99)
    pd 169316 72.3 14 14724571 (1), 16440327 (1), 11141234 (1), 19605737 (1) (see all 12)
    tyrosine 71 223 12709432 (3), 10085098 (3), 11237388 (3), 18713649 (3) (see all 99)

    Search CenterWatch for drugs/clinical trials and news about MAPK8 / MK08 

    Transcripts
    for MAPK8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPK8 gene (4 alternative transcripts): 
    NM_002750.2  NM_139046.1  NM_139047.1  NM_139049.1  

    Unigene Cluster for MAPK8:

    Mitogen-activated protein kinase 8
    Hs.138211  [show with all ESTs]
    Unigene Representative Sequence: AK094000
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432379 ENST00000429041 ENST00000374189(uc001jgn.3 uc001jgp.3 uc001jgq.3 uc009xoa.3)
    ENST00000426557 ENST00000476134 ENST00000374182 ENST00000374179(uc001jgm.3 uc001jgo.3 uc021ppy.1 uc010qgk.2)
    ENST00000374176 ENST00000374174 ENST00000469879 ENST00000471272 ENST00000469110
    ENST00000482840 ENST00000459755 ENST00000360332 ENST00000395611

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): MAPK8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK8
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK8:
    hsa-miR-3168 hsa-miR-219-2-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK8 (see all 4)
    OriGene shRNA RFP: MAPK8
    OriGene siRNA: MAPK8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK8
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK8 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK8 (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK8 (NM_002750)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPK8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPK8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK8

    Additional cDNA sequence: 

    AB451231.1 AB451271.1 AB451354.1 AB451398.1 AK094000.1 AK292523.1 BC130570.1 BC130572.1 
    BC144063.1 DQ234352.1 L26318.1 U34822.1 U35004.1 U35005.1 

    10 DOTS entries:

    DT.40125643  DT.100746960  DT.121226927  DT.91754467  DT.454686  DT.100732619  DT.100746961  DT.100746962 
    DT.65287263  DT.75198831 

    24/122 AceView cDNA sequences (see all 122):

    AI379407 BM698011 U34822 BU686309 BM771576 CA443441 CD236761 BF591196 
    AA808177 NM_139046 CD364702 NM_139047 BX418803 L26318 AK125150 BU183270 
    AW005952 U35004 NM_002750 BX117775 AA452406 NM_139049 AA488157 AA452842 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e
    SP1:                                            -                 -                                                   
    SP2:                                      -                       -                                                   
    SP3:                                      -                       -                                                   
    SP4:                                            -                 -                                                   
    SP5:                                      -     -     -           -                                                   


    ECgene alternative splicing isoforms for MAPK8

    Expression
    for MAPK8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAATACAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPK8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAPK8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK8

    SOURCE GeneReport for Unigene cluster: Hs.138211
        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK8 (see all 23): 
              Antiviral Response in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              Breast Cancer in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for MAPK8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK8 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAPK81 mitogen-activated protein kinase 8 87.2(n)
    97.19(a)    		   423778  XM_001233168.2  XP_001233169.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPK86
    		 --
    		 93(a)
    		 1 ↔ 1
    		 GL343297.1(584085-625480)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3984992 hypothetical protein LOC398499 80.03(n)    BC061937.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mapk82 mitogen-activated protein kinase 8 75.5(n)   65236  AB030900.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta bsk1 , 3 JNK cascade protein serine/threonine kinase3
    basket1    		 77(a)3
    68.23(n)1
    77.96(a)1    		   2 31B33
    448011  NM_001169459.11  NP_001162930.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea jnk-11 , 3 MAP kinase3
    Protein JNK-11    		 70(a)
    (best of 5)3
    63.83(n)1
    70.54(a)1    		   IV(6957865-6963780)3
    1774601  NM_001026099.21  NP_001021270.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATMPK136
    MPK116
    (see all 20)    		 mitogen-activated protein kinase 11
    (see all 20)    		 39(a)
    39(a)
    (see all 20)    		 many ↔ many
    many ↔ many
    (see all 20)    		 1(2434030-2435763)
    1(202136-204335)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 16)    		 CGMC_MAPKCMGC_2_ERK.14 - CGMC includes CDA, MAPK, ...
    CGMC_MAPKCMGC_2_SLT2y_ERK.2 - CGMC includes CDA, M...
    (see all 16)    		 39(a)
    38(a)
    (see all 16)    		 many ↔ many
    many ↔ many
    (see all 16)    		 10(20684568-20688500)
    6(29397209-29401633)


    ENSEMBL Gene Tree for MAPK8 (if available)
    TreeFam Gene Tree for MAPK8 (if available) 

    Paralogs
    for MAPK8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK8 gene
    MAPK92  MAPK122  MAPK132  MAPK112  MAPK142  MAPK102  
    18/104 SIMAP similar genes for MAPK8 using alignment to 7 protein entries:     MK08_HUMAN (see all proteins) (see all similar genes):
    MAPK10    MAPK9    STK11    MAPK14    MAPK11    MYO3B
    MAPK13    OXSR1    CDK14    MAPK3    CAMKK2    CDK19
    EIF2AK3    MOK    NLK    CDKL2    MAP2K3    STK38L

    MAPK8 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPK8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/622 NCBI SNPs in MAPK8 are shown (see all 622)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs111013121,2
    		C,F,H,--43872560(+) NNNNGG/ATAACA 4 -- us2k117Minor allele frequency- A:0.05NS EA NA 1700
    rs733080001,2
    		C,--43872574(+) TATCAC/TCTCCT 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs727943741,2
    		C,--43872709(+) TTAACC/GTTCCC 4 -- us2k10--------
    rs176979721,2
    		C,F,--43872802(+) TCCCCC/TGCTGA 4 -- us2k16Minor allele frequency- T:0.03NA 266
    rs801615551,2
    		F,--43872979(+) GAGCAT/GTGTGT 4 -- us2k11Minor allele frequency- G:0.10WA 118
    rs1121463171,2
    		--43873465(+) GCCTAG/CTAGGC 4 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs785851441,2
    		F,--43873547(+) TAAAAC/TCACAA 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs176979781,2
    		C,F,H,--43873600(+) GGAGGC/TGAGGA 4 -- us2k121Minor allele frequency- T:0.04NA NS EA 2320
    rs122539261,2
    		C,F,H,--43873839(+) TCTCTC/GTCTCC 4 -- us2k1 trp39Minor allele frequency- G:0.06NS EA NA WA 662
    rs176980021,2
    		C,F,H,--43873988(+) ATGCTA/GGTCAA 4 -- us2k127Minor allele frequency- G:0.04NA NS EA 2824

    HapMap Linkage Disequilibrium report for MAPK8 (49514698 - 49647403 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAPK8: --

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    Disorders / Diseases
    for MAPK8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPK8 for disorders           About GeneDecksing

    OMIM gene information: 601158    OMIM disorders: --

    20/191 diseases for MAPK8 (see all 191):    About MalaCards
    neurodegeneration    frozen shoulder    familial adenomatous polyposis    non-small cell lung carcinoma
    spastic paraplegia    diastolic heart failure    hereditary spastic paraplegia    anaplastic large cell lymphoma
    waldenstrom macroglobulinemia    bile duct carcinoma    multiple endocrine neoplasia    restrictive cardiomyopathy
    myeloid leukemia    brain injury    ataxia telangiectasia    avian influenza
    amyotrophic lateral sclerosis    chronic obstructive pulmonary disease    lupus erythematosus    ureteral obstruction

    6 diseases from the University of Copenhagen DISEASES database for MAPK8:
    Cancer     Vascular disease     Toxic encephalopathy     Parkinson's disease
    Diabetes mellitus     Alzheimer's disease

    10/93 Novoseek disease relationships for MAPK8 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 74.2 205 14523009 (4), 16085647 (2), 16630028 (2), 17121845 (2) (see all 99)
    tumors 67.9 389 19445931 (6), 10037172 (6), 12734425 (5), 12629045 (4) (see all 99)
    cancer 59.7 103 19766599 (4), 20354187 (3), 18008069 (3), 19445931 (3) (see all 71)
    inflammation 58.4 55 18984670 (2), 18506470 (2), 19717791 (2), 9482836 (1) (see all 47)
    neurodegenerative diseases 47.6 17 14744254 (2), 16794604 (1), 14989595 (1), 12480174 (1) (see all 15)
    leukemia 46.9 33 19468286 (3), 15767555 (2), 12898508 (2), 18031783 (2) (see all 28)
    shock 46.1 95 10082520 (5), 11050083 (4), 11527157 (4), 18036352 (2) (see all 57)
    colon cancer 44.8 28 19352384 (3), 19243468 (2), 17591974 (2), 14722256 (1) (see all 23)
    insulin resistance 43 54 16085647 (2), 19063863 (2), 12554784 (2), 19277946 (2) (see all 35)
    prostate cancer 42.4 65 12902351 (4), 17671214 (4), 12853969 (3), 19010898 (2) (see all 44)

    Human Genome Epidemiology (HuGE) Navigator: MAPK8 (9 documents)

    Export disorders for MAPK8 gene to outside databases

    Publications
    for MAPK8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK8 gene, integrated from 9 sources (see all 3553):
    (articles sorted by number of sources associating them with MAPK8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Selective interaction of JNK protein kinase isoforms with transcription factors. (PubMed id 8654373)1, 2, 3, 9 Gupta S....Davis R.J. (1996)
    2. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. (PubMed id 8137421)1, 2, 3 Derijard B....Davis R.J. (1994)
    3. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PubMed id 7839144)1, 2, 9 Derijard B.... Davis R.J. (1995)
    4. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. (PubMed id 21856198)1, 2 Miotto B. and Struhl K. (2011)
    5. A critical step for JNK activation: isomerization by the prolyl isomerase Pin1. (PubMed id 21660049)1, 2 Park J.E.... Cho S. (2011)
    6. Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis. (PubMed id 21148294)1, 2 Wang J.... Zhang J. (2011)
    7. JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. (PubMed id 21364637)1, 2 Tomlinson V....Basu S. (2010)
    8. JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. (PubMed id 20027304)1, 2 Nasrin N....Bordone L. (2009)
    9. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. (PubMed id 18570871)1, 2 Wei Y....Levine B. (2008)
    10. Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing. (PubMed id 17158878)1, 2 Zihni C....Morris J.D. (2007)

    External Searches for MAPK8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAPK8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5599 HGNC: 6881 AceView: MAPK8 Ensembl:ENSG00000107643 euGenes: HUgn5599
    ECgene: MAPK8 Kegg: 5599 H-InvDB: MAPK8

    Other Databases showing MAPK8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAPK8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK8 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases

    Intellectual Property
    for MAPK8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPK8 gene:
    Search GeneIP for patents involving MAPK8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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