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MAPK8 Gene

protein-coding   GIFtS: 76
GCID: GC10P049514

Mitogen-Activated Protein Kinase 8


(Previous symbol: PRKM8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 81 2     JNK2
PRKM81 2 3 5     JNK1A22
JNK12 3 5     JNK21B1/22
SAPK12 3 5     Mitogen-Activated Protein Kinase 8 Isoform JNK1 Alpha12
JUN N-Terminal Kinase1 2     Mitogen-Activated Protein Kinase 8 Isoform JNK1 Beta22
Stress-Activated Protein Kinase 1c2 3     Stress-Activated Protein Kinase 12
JNK-462 3     SAPK1C3
SAPK1c2 3     MAPK 83
C-Jun N-Terminal Kinase 12 3     Stress-Activated Protein Kinase JNK13
MAP Kinase 82 3     EC 2.7.118
EC 2.7.11.243 8     

External Ids:    HGNC: 68811   Entrez Gene: 55992   Ensembl: ENSG000001076437   OMIM: 6011585   UniProtKB: P459833   

Export aliases for MAPK8 gene to outside databases

Previous GC identifers: GC10P048468 GC10P049407 GC10P048954 GC10P049279 GC10P043874


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK8 Gene:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and
targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell
stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for
TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to
be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested
that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively
spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Jun 2013)

GeneCards Summary for MAPK8 Gene:
MAPK8 (mitogen-activated protein kinase 8) is a protein-coding gene. Diseases associated with MAPK8 include frozen shoulder, and restrictive cardiomyopathy. GO annotations related to this gene include protein serine/threonine kinase activity and JUN kinase activity. An important paralog of this gene is MAPK9.

UniProtKB/Swiss-Prot: MK08_HUMAN, P45983
Function: Serine/threonine-protein kinase involved in various processes such as cell proliferation,
differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as
proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal
kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7
phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors,
primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity.
Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4
acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for
replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including
p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation
of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the
antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2
dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule
dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic
activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the
ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the
deacetylase SIRT1, ELK1, or the E3 ligase ITCH
Function: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1,
alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation
between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms

summary for MAPK8 Gene:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK8 gene promoter:
         AP-1   ATF-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPK8 promoter sequence
   Search Chromatin IP Primers for MAPK8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.22   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11

MAPK8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P049514:  view genomic region     (about GC identifiers)

Start:
49,514,698 bp from pter      End:
49,647,403 bp from pter
Size:
132,706 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MK08_HUMAN, P45983 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 8  
Size: 427 amino acids; 48296 Da
Cofactor: Magnesium
Subunit: Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and
SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53
and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and ARHGEF28 (By similarity). Interacts
(phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells (By similarity).
Interacts with NFATC4. Interacts with MECOM; regulates JNK signaling. Interacts with PIN1; this interaction
mediates MAPK8 conformational changes leading to the binding of MAPK8 to its substrates
Selected PDB 3D structures from and Proteopedia for MAPK8 (see all 27):
1UKH (3D)        1UKI (3D)        2G01 (3D)        2GMX (3D)        2H96 (3D)        2NO3 (3D)    
Secondary accessions: B5BTZ5 B7ZLV4 D3DX88 D3DX92 Q15709 Q15712 Q15713
Alternative splicing: 4 isoforms:  P45983-1   P45983-2   P45983-3   P45983-4   (Contains a phosphoserine at position 377)

Explore the universe of human proteins at neXtProt for MAPK8: NX_P45983

Explore proteomics data for MAPK8 at MOPED

Post-translational modifications: 

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by
    TAOK21
  • Ubiquitination2 at Lys166
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPK8 (P45983) (see all 27)
     KELIYKE  ILDFGLA  LDFGLAR  LLSKMLV 


    See MAPK8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265476.1  NP_001265477.1  NP_002741.1  NP_620634.1  NP_620637.1  

    ENSEMBL proteins: 
     ENSP00000387936   ENSP00000393223   ENSP00000363304   ENSP00000397729   ENSP00000363297  
     ENSP00000363294   ENSP00000363291   ENSP00000363289   ENSP00000353483   ENSP00000378974  
    Reactome Protein details: P45983

    MAPK8 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAPK8 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MAPK8
    OriGene Purified Proteins for MAPK8
    OriGene Protein Over-expression Lysate for MAPK8
    OriGene MassSpec for MAPK8
    OriGene Custom Protein Services for MAPK8
    GenScript Custom Purified and Recombinant Proteins Services for MAPK8
    Novus Biologicals MAPK8 Proteins
    Novus Biologicals MAPK8 Lysates
    Sino Biological Recombinant Protein for MAPK8
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAPK8

    MAPK8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK8
    R&D Systems Antibodies for MAPK8 (JNK1)
    Cell Signaling Technology (CST) Antibodies for MAPK8  (JNK1)
    OriGene Antibodies for MAPK8
    OriGene Custom Antibody Services for MAPK8
    Novus Biologicals MAPK8 Antibodies
    Abcam antibodies for MAPK8 (P45983, P53779, P45984)
    Cloud-Clone Corp. Antibodies for MAPK8
    ThermoFisher Antibody for MAPK8
    LSBio Antibodies in human, mouse, rat for MAPK8

    MAPK8 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of MAPK8
    OriGene Custom Assay Services for MAPK8
    R&D Systems ELISAs for MAPK8 (JNK1)         (see all)
    GenScript Custom Assay Services for MAPK8
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK8 (JNK1)
    Enzo Life Sciences assays for MAPK8
    Cloud-Clone Corp. ELISAs for MAPK8
    Cloud-Clone Corp. CLIAs for MAPK8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 8
    JNK subfamily
    Mitogen-activated protein kinases

    Selected InterPro protein domains (see all 6):
     IPR008351 MAPK_JNK
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR003527 MAP_kinase_CS

    Graphical View of Domain Structure for InterPro Entry P45983

    ProtoNet protein and cluster: P45983

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008351 JNK MAP kinase signature


    UniProtKB/Swiss-Prot: MK08_HUMAN, P45983
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK08_HUMAN, P45983
    Function: Serine/threonine-protein kinase involved in various processes such as cell proliferation,
    differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as
    proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal
    kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7
    phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors,
    primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity.
    Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4
    acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for
    replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including
    p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation
    of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the
    antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2
    dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule
    dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic
    activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the
    ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the
    deacetylase SIRT1, ELK1, or the E3 ligase ITCH
    Function: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1,
    alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation
    between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases,
    MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183
    preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by SERPINB3

         Genatlas biochemistry entry for MAPK8:
    mitogen-activated protein kinase 8,with three alternatively spliced isoforms JNK1,JNK2,JNK3 (MAP kinase),activated
    by UV irradiation and H-RAS,phosphorylating JUN

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14967141
    GO:0004705JUN kinase activity IDA--
    GO:0004707MAP kinase activity ----
         
    MAPK8 for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for MAPK8:
     Decreased Hepatitis C virus re  Decreased focal adhesion (FA)   Increased S DNA content  Increased cell death HMECs cel 
     Increased cell death in breast  Increased circadian period len  Increased mitotic index  Increased telomerase activity 
     Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mapk8) (see all 22):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 

    MAPK8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mapk8tm1Flv for MAPK8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPK8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK8

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPK8:
    hsa-mir-125a-5p (MIRT021289), hsa-mir-33a-5p (MIRT028235), hsa-mir-193b-3p (MIRT016510), hsa-mir-421 (MIRT016104), hsa-mir-10a-5p (MIRT025602), hsa-mir-140-3p (MIRT021678), hsa-mir-877-5p (MIRT037323), hsa-mir-214-3p (MIRT005427)

    Block miRNA regulation of human, mouse, rat MAPK8 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MAPK8:
    hsa-miR-3168 hsa-miR-219-2-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAPK8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPK8
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK8

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK8 (see all 23)
    OriGene ORF clones in mouse, rat for MAPK8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK8 (NM_002750)
    Sino Biological Human cDNA Clone for MAPK8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK8
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MK08_HUMAN, P45983: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular3
    mitochondrion3
    cytoskeleton2
    endoplasmic reticulum2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    MAPK8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK8 About   (see all 181)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TNFR1 Pathway0.56
    Apoptotic Pathways Triggered By HIV10.42
    TNF Signaling0.55
    Apoptosis through Death Receptors0.42
    Apoptosis and survival TNFR1 signaling pathway0.52
    Fas Signaling0.35
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    TWEAK Signaling Pathway0.31
    2Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Development EGFR signaling via PIP30.40
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Development PDGF signaling via MAPK cascades0.41
    Apoptosis and survival Anti apoptotic action of membrane bound ESR10.35
    3NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    4RANK Signaling in Osteoclasts
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANKL/RANK Signaling Pathway0.31
    RANK Signaling in Osteoclasts0.45
    5G protein signaling Ras family GTPases in kinase cascades scheme
    G protein signaling Ras family GTPases in kinase cascades scheme 0.44
    Oncostatin M Signaling Pathway0.37
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Activation of the AP-1 family of transcription factors0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for MAPK8 (see all 7)
        NOD-like Receptor Signaling Pathways
    Wnt Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK8 (see all 114)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPK8
        MAP Kinase Signaling

    5 Tocris Bioscience Pathways for MAPK8
        Akt Pathway
    Insulin Pathway
    Toll-like Receptor Pathway
    VEGF Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MAPK8 (see all 38)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Development Endothelin-1/EDNRA signaling

    Selected BioSystems Pathways for MAPK8 (see all 77)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Keap1-Nrf2 Pathway
    EBV LMP1 signaling

    4 Sino Biological Pathways for MAPK8
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    Death Receptor Signaling
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for MAPK8 (see all 9)
        NRIF signals cell death from the nucleus
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
    FCERI mediated MAPK activation
    Activation of BIM and translocation to mitochondria
    NRAGE signals death through JNK

    3 PharmGKB Pathways for MAPK8
        EGFR Inhibitor Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for MAPK8) (see all 40):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    FoxO signaling pathway
    Protein processing in endoplasmic reticulum


    MAPK8 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK8 (see all 23): 
              Antiviral Response in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              Breast Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK8 (P459831, 2, 3 ENSP000003534834) via UniProtKB, MINT, STRING, and/or I2D (see all 295)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054121, 2, 3, ENSP000003602664EBI-286483,EBI-852823 MINT-7148314 I2D: score=11 STRING: ENSP00000360266
    TP53P046372, 3, ENSP000002693054MINT-61312 I2D: score=5 STRING: ENSP00000269305
    BCL2P104152, 3, ENSP000003296234MINT-56639 I2D: score=4 STRING: ENSP00000329623
    BCL2L1Q078172, 3, ENSP000003025644MINT-56640 I2D: score=4 STRING: ENSP00000302564
    CRKP461082, 3, ENSP000003005744MINT-7103547 I2D: score=4 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 42):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----

    MAPK8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MAPK8
      Browse compounds at ApexBio 

    Compounds for MAPK8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS JNK 6oSelective JNK inhibitor[894804-07-0]
    SP 600125Novel and selective JNK inhibitor[129-56-6]
    TCS JNK 5aSelective inhibitor of JNK2 and JNK3[312917-14-9]
    SU 3327Selective JNK inhibitor[40045-50-9]
    BI 78D3 Selective, competitive JNK inhibitor [883065-90-5]

    3 HMDB Compounds for MAPK8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    6 DrugBank Compounds for MAPK8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One-- --target--10592235
    2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE-- --target--10592235
    2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide-- --target--10592235
    5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE-- --target--10592235
    6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE-- --target--10592235
    N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for MAPK8 gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp 600125 97.5 1060 15454338 (4), 17322004 (4), 14766793 (3), 15242986 (3) (see all 99)
    sb 203580 92.2 314 18655782 (4), 18222647 (3), 18718914 (2), 9598985 (2) (see all 99)
    pd 98,059 89.3 240 11164710 (2), 16480952 (2), 17191113 (2), 9603971 (1) (see all 99)
    anisomycin 81.1 110 17699104 (6), 8626428 (3), 12220537 (3), 16672691 (2) (see all 63)
    ly294002 74.7 76 10628325 (2), 16722795 (2), 9878764 (2), 12555073 (2) (see all 57)
    kt 7515 74.2 7 9631443 (2), 12376548 (1), 11279271 (1), 11756493 (1) (see all 6)
    n acetylcysteine 74 137 19176594 (3), 8824287 (2), 18038907 (2), 18679584 (2) (see all 84)
    phosphatidylinositol 72.9 135 9315636 (4), 10050043 (3), 16000309 (3), 17008315 (3) (see all 99)
    pd 169316 72.3 14 14724571 (1), 16440327 (1), 11141234 (1), 19605737 (1) (see all 12)
    tyrosine 71 223 12709432 (3), 10085098 (3), 11237388 (3), 18713649 (3) (see all 99)



    MAPK8 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for MAPK8 gene (5 alternative transcripts): 
    NM_001278547.1  NM_001278548.1  NM_002750.3  NM_139046.2  NM_139049.2  

    Unigene Cluster for MAPK8:

    Mitogen-activated protein kinase 8
    Hs.138211  [show with all ESTs]
    Unigene Representative Sequence: AK094000
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432379 ENST00000429041 ENST00000374189(uc001jgn.3 uc001jgp.3 uc001jgq.3 uc009xoa.3)
    ENST00000426557 ENST00000476134 ENST00000374182 ENST00000374179(uc001jgm.3 uc001jgo.3 uc021ppy.1 uc010qgk.2)
    ENST00000374176 ENST00000374174 ENST00000469879 ENST00000471272 ENST00000469110
    ENST00000482840 ENST00000459755 ENST00000360332 ENST00000395611
    miRNA
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    Block miRNA regulation of human, mouse, rat MAPK8 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MAPK8:
    hsa-miR-3168 hsa-miR-219-2-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAPK8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAPK8
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    OriGene ORF clones in mouse, rat for MAPK8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK8 (NM_002750)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK8
    Primer
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    OriGene qPCR primer pairs and template standards for MAPK8
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK8
      QuantiTect SYBR Green Assays in human, mouse, rat MAPK8
      QuantiFast Probe-based Assays in human, mouse, rat MAPK8

    Additional mRNA sequence: 

    AB451231.1 AB451271.1 AB451354.1 AB451398.1 AK094000.1 AK292523.1 BC130570.1 BC130572.1 
    BC144063.1 DQ234352.1 L26318.1 U34822.1 U35004.1 U35005.1 

    10 DOTS entries:

    DT.40125643  DT.100746960  DT.121226927  DT.91754467  DT.454686  DT.100732619  DT.100746961  DT.100746962 
    DT.65287263  DT.75198831 

    Selected AceView cDNA sequences (see all 122):

    AK125150 U34822 NM_002750 NM_139047 AA488157 U35005 BX418803 L26318 
    AI379407 AI961756 AA808177 BX117775 U35004 AA452842 NM_139049 CD364702 
    AA452406 CD236761 AW005952 BU183270 CA443441 BF591196 BM771576 BM698011 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e
    SP1:                                            -                 -                                                   
    SP2:                                      -                       -                                                   
    SP3:                                      -                       -                                                   
    SP4:                                            -                 -                                                   
    SP5:                                      -     -     -           -                                                   


    ECgene alternative splicing isoforms for MAPK8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPK8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAATACAT
    MAPK8 Expression
    About this image


    MAPK8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Neural Tube (Nervous System)
             Rhombencephalon
    MAPK8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.138211
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK8 (see all 23): 
              Antiviral Response in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              Breast Cancer in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK8
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    QuantiFast Probe-based Assays in human, mouse, rat MAPK8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAPK8 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk81 , 5 mitogen-activated protein kinase 81, 5 91.67(n)1
    97.63(a)1
      14 (20.22 cM)5
    264191  NM_016700.41  NP_057909.11 
     333778985 
    chicken
    (Gallus gallus)
    Aves MAPK81 mitogen-activated protein kinase 8 89.15(n)
    99.06(a)
      423778  XM_001233168.3  XP_001233169.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK86
    mitogen-activated protein kinase 8
    93(a)
    1 ↔ 1
    GL343297.1(576935-625480)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984992 hypothetical protein LOC398499 80.03(n)    BC061937.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapk82 mitogen-activated protein kinase 8 75.5(n)   65236  AB030900.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bsk1 , 3 JNK cascade protein serine/threonine
    kinase3
    basket1
    77(a)3
    68.6(n)1
    79.89(a)1
      2 31B33
    448011  NM_001169459.11  NP_001162930.11 
    worm
    (Caenorhabditis elegans)
    Secernentea jnk-11 , 3 MAP kinase3
    jnk-11
    70(a)
    (best of 5)3
    64.59(n)1
    71.67(a)1
      IV(6957865-6963780)3
    1774601  NM_001026099.31  NP_001021270.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HOG16
    Mitogen-activated protein kinase involved in osmor...
    34(a)
    1 → many
    XII(371620-372927) YLR113W


    ENSEMBL Gene Tree for MAPK8 (if available)
    TreeFam Gene Tree for MAPK8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK8 gene
    MAPK92  MAPK122  MAPK132  MAPK112  MAPK142  MAPK102  
    Selected SIMAP similar genes for MAPK8 using alignment to 7 protein entries:     MK08_HUMAN (see all proteins) (see all similar genes):
    MAPK10    MAPK9    STK11    MAPK14    MAPK11    MYO3B
    MAPK13    OXSR1    CDK14    MAPK3    CAMKK2    CDK19
    EIF2AK3    MOK    NLK    CDKL2    MAP2K3    STK38L

    MAPK8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPK8 (see all 766)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0422584
    A renal clear cell carcinoma sample4--see VAR_0422582 G S mis40--------
    VAR_0422594
    A glioblastoma multiforme sample4--see VAR_0422592 G R mis40--------
    rs1115404941,2
    C--43901865(+) TTTTTT/-GAGAC 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs30477641,2
    C--49612001(+) tgtgt-/GTG/  
      GTGTGT
    atttt
    8 -- cds11NA 2
    rs1112869211,2
    C,F--49612413(+) CCAGGC/ATGGTC 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs106570701,2
    C--49613149(+) TATAT-/AT    
       
    /ATAT
    CTACA
    4 -- int11NA 2
    rs800191611,2
    C--49621284(+) ATGAA-/TATGAA
            
    CATGG
    4 -- cds10--------
    rs1452826791,2
    C--49630051(+) TATTT-/ATTT  
            
    TTGAG
    4 -- int10--------
    rs111013121,2
    C,F,H--50000386(+) CTTTGG/ATAACA 4 -- us2k117Minor allele frequency- A:0.05NS EA NA 1700
    rs1432842001,2
    --50000391(+) GTAACA/TATATA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPK8 (49514698 - 49647403 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MAPK8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518744CNV Loss19592680
    nsv895365CNV Loss21882294
    nsv825373CNV Loss20364138
    nsv519701CNV Loss19592680
    nsv895372CNV Gain21882294
    nsv895371CNV Gain21882294
    nsv895369CNV Gain21882294
    nsv7203OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK8
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601158    OMIM disorders: --

    Selected diseases for MAPK8 (see all 161):    
    About MalaCards
    frozen shoulder    restrictive cardiomyopathy    diastolic heart failure    tauopathy
    avian influenza    keloids    ureteral obstruction    polyploidy
    memory impairment    waldenstrom macroglobulinemia    bile duct carcinoma    pulmonary fibrosis
    macroglobulinemia    acute liver failure    retinopathy of prematurity    agammaglobulinemia
    hiv/aids    colon adenocarcinoma    diabetic neuropathy    pterygium

    5 diseases from the University of Copenhagen DISEASES database for MAPK8:
    Cancer     Vascular disease     Toxic encephalopathy     Parkinson's disease
    Diabetes mellitus

    MAPK8 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MAPK8 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 74.2 205 14523009 (4), 16085647 (2), 16630028 (2), 17121845 (2) (see all 99)
    tumors 67.9 389 19445931 (6), 10037172 (6), 12734425 (5), 12629045 (4) (see all 99)
    cancer 59.7 103 19766599 (4), 20354187 (3), 18008069 (3), 19445931 (3) (see all 71)
    inflammation 58.4 55 18984670 (2), 18506470 (2), 19717791 (2), 9482836 (1) (see all 47)
    neurodegenerative diseases 47.6 17 14744254 (2), 16794604 (1), 14989595 (1), 12480174 (1) (see all 15)
    leukemia 46.9 33 19468286 (3), 15767555 (2), 12898508 (2), 18031783 (2) (see all 28)
    shock 46.1 95 10082520 (5), 11050083 (4), 11527157 (4), 18036352 (2) (see all 57)
    colon cancer 44.8 28 19352384 (3), 19243468 (2), 17591974 (2), 14722256 (1) (see all 23)
    insulin resistance 43 54 16085647 (2), 19063863 (2), 12554784 (2), 19277946 (2) (see all 35)
    prostate cancer 42.4 65 12902351 (4), 17671214 (4), 12853969 (3), 19010898 (2) (see all 44)

    Genetic Association Database (GAD): MAPK8
    Human Genome Epidemiology (HuGE) Navigator: MAPK8 (9 documents)

    Export disorders for MAPK8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for MAPK8 gene, integrated from 10 sources (see all 3596) (see top 10):
    (articles sorted by number of sources associating them with MAPK8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Selective interaction of JNK protein kinase isoforms with transcription factors. (PubMed id 8654373)1, 2, 3, 9 Gupta S.... Davis R.J. (EMBO J. 1996)
    2. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. (PubMed id 8137421)1, 2, 3 Derijard B....Davis R.J. (Cell 1994)
    3. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PubMed id 7839144)1, 2, 9 Derijard B.... Davis R.J. (Science 1995)
    4. A critical step for JNK activation: isomerization by the prolyl isomerase Pin1. (PubMed id 21660049)1, 2 Park J.E.... Cho S. (Cell Death Differ. 2012)
    5. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. (PubMed id 21856198)1, 2 Miotto B. and Struhl K. (Mol. Cell 2011)
    6. Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis. (PubMed id 21148294)1, 2 Wang J.... Zhang J. (Mol. Biol. Cell 2011)
    7. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. (PubMed id 21364637)1, 2 Tomlinson V....Basu S. (Cell Death Dis. 2010)
    10. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    11. JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. (PubMed id 20027304)1, 2 Nasrin N.... Bordone L. (PLoS ONE 2009)
    12. The G/G genotype of a single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binding of AP2alpha. (PubMed id 18036196)1, 4 Osawa H....Makino H. (Clin. Endocrinol. (Oxf) 2008)
    13. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. (PubMed id 18570871)1, 2 Wei Y.... Levine B. (Mol. Cell 2008)
    14. Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing. (PubMed id 17158878)1, 2 Zihni C....Morris J.D. (J. Biol. Chem. 2007)
    15. Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1. (PubMed id 17296730)1, 2 Zhang L.... Sharrocks A.D. (Mol. Cell. Biol. 2007)
    16. Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2- AP-1 induced cell transformation. (PubMed id 17875713)1, 2 Yao K.... Dong Z. (Cancer Res. 2007)
    17. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. (PubMed id 16581800)1, 2 Hu Y. and Mivechi N.F. (Mol. Cell. Biol. 2006)
    18. Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. (PubMed id 15693750)1, 2 Jagadish N.... Suri A. (Biochem. J. 2005)
    19. JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis. (PubMed id 12514174)1, 2 Chang N.-S.... Ensign A. (J. Biol. Chem. 2003)
    20. Synergistic activation of stress-activated protein kinase 1/c-Jun N- terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. (PubMed id 11062067)1, 2 Fleming Y....Cohen P. (Biochem. J. 2000)
    21. The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death. (PubMed id 10856240)1, 2 Kurokawa M.... Hirai H. (EMBO J. 2000)
    22. Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway. (PubMed id 16086581)1, 9 Adler V....Pincus M.R. (Biochemistry 2005)
    23. Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells. (PubMed id 19996270)1, 9 Cui J....Zhang J. (Mol. Cancer Ther. 2009)
    24. Reversing chemoresistance in cisplatin-resistant human ovarian cancer cells: a role of c-Jun NH2-terminal kinase 1. (PubMed id 16105650)1, 9 Li F....Ma D. (Biochem. Biophys. Res. Commun. 2005)
    25. Identification of a hydrogen peroxide-induced PP1-JNK1-Sp1 signaling pathway for gene regulation. (PubMed id 16815888)1, 9 Chu S. and Ferro T.J. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006)
    26. Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125. (PubMed id 15141161)2, 9 Heo Y.S.... Yang C.H. (EMBO J. 2004)
    27. Nitric oxide inhibits an interaction between JNK1 and c-Jun through nitrosylation. (PubMed id 17054907)1, 9 Park H.S....Choi E.J. (Biochem. Biophys. Res. Commun. 2006)
    28. Elevated JNK activation contributes to the pathogenesis of human brain tumors. (PubMed id 12140754)1, 9 Antonyak M.A....Wong A.J. (Oncogene 2002)
    29. Glutathione S-transferase pi regulates UV-induced JNK signaling in SH-SY5Y neuroblastoma cells. (PubMed id 19159663)1, 9 Castro-Caldas M....Gama M.J. (Neurosci. Lett. 2009)
    30. c-JUN N-terminal kinase-1 (JNK1) but not JNK2 or JNK3 is involved in UV signal transduction in human epidermis. (PubMed id 16824735)1, 9 Katagiri C....Hibino T. (J. Dermatol. Sci. 2006)
    31. JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. (PubMed id 16166642)1, 9 Kadoya T....Ronai Z. (Mol. Cell. Biol. 2005)
    32. JNK regulates HIPK3 expression and promotes resistance to Fas- mediated apoptosis in DU 145 prostate carcinoma cells. (PubMed id 14766760)1, 9 Curtin J.F. and Cotter T.G. (J. Biol. Chem. 2004)
    33. Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells. (PubMed id 14724588)1, 9 Mingo-Sion A.M....Van Den Berg C.L. (Oncogene 2004)
    34. Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation. (PubMed id 12756254)1, 9 Nihalani D.... Holzman L.B. (J. Biol. Chem. 2003)
    35. Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK. (PubMed id 13130464)1, 9 Sundarrajan M....Firestein G.S. (Arthritis Rheum. 2003)
    36. c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production. (PubMed id 12847227)1, 9 Utsugi M....Mori M. (J. Immunol. 2003)
    37. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. (PubMed id 12417588)1, 9 Lee Y.H....White M.F. (J. Biol. Chem. 2003)
    38. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. (PubMed id 10713157)1, 9 Cheng J.... Su B. (Mol. Cell. Biol. 2000)
    39. Sustained c-Jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation. (PubMed id 20145041)1, 9 Wang J....Cui X. (Mol. Cancer Res. 2010)
    40. JNK1, JNK2, and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells. (PubMed id 20525557)1, 9 Yan F....Ma Q.M. (amp 2010)
    41. TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation. (PubMed id 17074809)1, 9 Zhong S....Johnson D.L. (Mol. Cell. Biol. 2007)
    42. Dynamic positive feedback phosphorylation of mixed lineage kinase 3 by JNK reversibly regulates its distribution to Triton-soluble domains. (PubMed id 16687404)1, 9 Schachter K.A....Gallo K.A. (J. Biol. Chem. 2006)
    43. The c-Jun N-terminal kinase 1 activity is differentially regulated by specific mechanisms during apoptosis. (PubMed id 14514687)1, 9 Ham Y.M....Lee S.K. (J. Biol. Chem. 2003)
    44. gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes. (PubMed id 9045910)1, 9 Jabado N....Hivroz C. (Eur. J. Immunol. 1997)
    45. The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits. (PubMed id 19620725)1, 9 Zhong S. and Johnson D.L. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    46. Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death. (PubMed id 19864026)1, 9 Gancz D....Fishelson Z. (Mol. Immunol. 2009)
    47. Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. (PubMed id 17584736)1, 9 Zhong J. and Kyriakis J.M. (J. Biol. Chem. 2007)
    48. Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases. (PubMed id 16533805)1, 9 Ho D.T....Bardwell L. (J. Biol. Chem. 2006)
    49. Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK. (PubMed id 15979846)1, 9 Lo R.K....Wong Y.H. (Cell. Signal. 2006)
    50. Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells. (PubMed id 16328781)1, 9 Lee C.C....Shyu K.G. (J. Biomed. Sci. 2006)
    51. TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation. (PubMed id 15665513)1, 9 Ahn D.H....Kim Y.S. (Cell. Physiol. Biochem. 2005)
    52. Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis. (PubMed id 12206715)1, 9 Saeki K....Yuo A. (Biochem. J. 2002)
    53. Retinoblastoma protein interacts with ATF2 and JNK/p38 in stimulating the transforming growth factor-beta2 promoter. (PubMed id 11566021)1, 9 Li H. and Wicks W.D. (Arch. Biochem. Biophys. 2001)
    54. Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade. (PubMed id 10913135)1, 9 Fan M....Chambers T.C. (J. Biol. Chem. 2000)
    55. ASK1 is essential for JNK/SAPK activation by TRAF2. (PubMed id 9774977)1, 9 Nishitoh H.... Ichijo H. (Mol. Cell 1998)
    56. c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors. (PubMed id 9405416)1, 9 Fuchs S.Y....Ronai Z. (J. Biol. Chem. 1997)
    57. Mitogen-activated protein kinase kinase 7 is an activator of the c- Jun NH2-terminal kinase. (PubMed id 9207092)1, 9 Tournier C.... Davis R.J. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    58. c-Jun-NH2 terminal kinase (JNK)-mediates AP-1 activation by thioredoxin: phosphorylation of cJun, JunB, and Fra-1. (PubMed id 19859790)1, 9 Das K.C. and Muniyappa H. (Mol. Cell. Biochem. 2010)
    59. REDOX reaction at ASK1-Cys250 is essential for activation of JNK and induction of apoptosis. (PubMed id 19570911)1, 9 Nadeau P.J....Landry J. (Mol. Biol. Cell 2009)
    60. Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation. (PubMed id 19638579)1, 9 Uchida S....Yamashita K. (Cancer Res. 2009)
    61. Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide. (PubMed id 19748889)1, 9 Widenmaier S.B....McIntosh C.H. (J. Biol. Chem. 2009)
    62. c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer. (PubMed id 19204086)1, 9 Choi H.S....Dong Z. (Mol. Cell. Biol. 2009)
    63. Adrenomedullin promotes cell cycle transit and up-regulates cyclin D1 protein level in human glioblastoma cells through the activation of c-Jun/JNK/AP-1 signal transduction pathway. (PubMed id 19166930)1, 9 Ouafik L....Berthois Y. (Cell. Signal. 2009)
    64. DNA damage-dependent translocation of B23 and p19 ARF is regulated by the Jun N-terminal kinase pathway. (PubMed id 18316603)1, 9 Yogev O....Shaulian E. (Cancer Res. 2008)
    65. TNF-alpha represses connexin43 expression in HaCat keratinocytes via activation of JNK signaling. (PubMed id 18297686)1, 9 Tacheau C....Verrecchia F. (J. Cell. Physiol. 2008)
    66. TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. (PubMed id 18922473)1, 9 Yamashita M....Zhang Y.E. (Mol. Cell 2008)
    67. c-Jun NH2 terminal kinase activation and decreased expression of mitogen-activated protein kinase phosphatase-1 play important roles in invasion and angiogenesis of urothelial carcinomas. (PubMed id 17690186)1, 9 Shimada K....Konishi N. (Am. J. Pathol. 2007)
    68. Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5. (PubMed id 17541429)1, 9 Kim E.K....Choi E.J. (Cell Death Differ. 2007)
    69. Varicella-zoster virus infection of human fibroblast cells activates the c-Jun N-terminal kinase pathway. (PubMed id 17079291)1, 9 Zapata H.J....Moffat J.F. (J. Virol. 2007)
    70. The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. (PubMed id 17189706)1, 9 Blonska M.... Lin X. (Immunity 2007)
    71. Paclitaxel enhances thrombin-induced endothelial tissue factor expression via c-Jun terminal NH2 kinase activation. (PubMed id 16794185)1, 9 StAohli B.E....Tanner F.C. (Circ. Res. 2006)
    72. Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase. (PubMed id 17008315)1, 9 Liu A.M....Wong Y.H. (J. Biol. Chem. 2006)
    73. UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal. (PubMed id 15769735)1, 9 Charruyer A....JaffrAczou J.P. (J. Biol. Chem. 2005)
    74. Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells. (PubMed id 16176806)1, 9 Miyata Y....Ito A. (Biochem. Biophys. Res. Commun. 2005)
    75. Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. (PubMed id 15629131)1, 9 Hsu L.J....Chang N.S. (Biochem. Biophys. Res. Commun. 2005)
    76. Interaction of Neisseria meningitidis with human brain microvascular endothelial cells: role of MAP- and tyrosine kinases in invasion and inflammatory cytokine release. (PubMed id 15527495)1, 9 Sokolova O....Schubert-Unkmeir A. (Cell. Microbiol. 2004)
    77. C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma. (PubMed id 12538493)1, 9 Yang Y.M....Mercola D. (Clin. Cancer Res. 2003)
    78. A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. (PubMed id 12788955)1, 9 Ho D.T.... Bardwell L. (J. Biol. Chem. 2003)
    79. [Involvement of JNK and caspase-3 in human lymphoma cell apoptosis induced by Prunella vulgaris]. (PubMed id 20450729)1, 9 Liu X.K....Zhang M.Z. (Zhonghua Yi Xue Za Zhi 2010)
    80. IL-6 and high glucose synergistically upregulate MMP-1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun. (PubMed id 20225236)1, 9 Li Y....Huang Y. (J. Cell. Biochem. 2010)
    81. Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation. (PubMed id 20156194)1, 9 Nakagawa K....Nishina H. (Biochem. J. 2010)
    82. Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: involvement of ERK, JNK, AP-1, and NF-kappaB. (PubMed id 20432452)1, 9 Yang C.M....Hsiao L.D. (J. Cell. Physiol. 2010)
    83. Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. (PubMed id 19782079)1, 9 Kluwe J....Schwabe R.F. (Gastroenterology 2010)
    84. JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2. (PubMed id 19778898)1, 9 Gubern A....Claro E. (J. Biol. Chem. 2009)
    85. Lipopolysaccharide-induced apoptosis in transformed bovine brain endothelial cells and human dermal microvessel endothelial cells: the role of JNK. (PubMed id 19454725)1, 9 Karahashi H....Arditi M. (J. Immunol. 2009)
    86. The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. (PubMed id 19060920)1, 9 Li D.D....Zhu X.F. (Oncogene 2009)
    87. Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress- induced cell death by modulating JNK activation. (PubMed id 19604147)1, 9 Chen C.B.... Porter A.G. (Biosci. Rep. 2009)
    88. Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer. (PubMed id 19041150)1, 9 Chang Q....Chen F. (J. Hepatol. 2009)
    89. ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway. (PubMed id 19270716)1, 9 Jeon Y.J.... Chung C.H. (EMBO Rep. 2009)
    90. c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer. (PubMed id 19056926)1, 9 Wang J....Wong B.C. (Carcinogenesis 2009)
    91. Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases. (PubMed id 18713996)1, 9 Yoshizawa T....Firestein G.S. (J. Immunol. 2008)
    92. Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury. (PubMed id 18293403)1, 9 Katsura H....Noguchi K. (Glia 2008)
    93. JNK supports survival in melanoma cells by controlling cell cycle arrest and apoptosis. (PubMed id 18541008)1, 9 Alexaki V.I....Mauviel A. (amp 2008)
    94. Regulation of IGFBP6 gene and protein is mediated by the inverse expression and function of c-jun N-terminal kinase (JNK) and NFkappaB in a model of oral tumor cells. (PubMed id 18982452)1, 9 Cacalano N.A....Jewett A. (Apoptosis 2008)
    95. 15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53. (PubMed id 18718914)1, 9 Ho T.C....Tsao Y.P. (J. Biol. Chem. 2008)
    96. [Study on the mechanism of DDP-resistance mediated by phosphate JNK in gastric cancer]. (PubMed id 18344085)1, 9 Li D.W....Wu Q. (Zhonghua Wei Chang Wai Ke Za Zhi 2008)
    97. Expression and regulation of c-Jun N-terminal kinase (JNK) in endometrial cells in vivo and in vitro. (PubMed id 18506470)1, 9 Kizilay G....Kayisli U.A. (Histochem. Cell Biol. 2008)
    98. JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin. (PubMed id 18713649)1, 9 Huang Z....Ge B.X. (Cell. Signal. 2008)
    99. Distinct role of c-Jun N-terminal kinase isoforms in human neutrophil apoptosis regulated by tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor. (PubMed id 18439101)1, 9 Kato T....Kitagawa S. (amp 2008)
    100. Tumor necrosis factor-alpha-induced reactive oxygen species formation is mediated by JNK1-dependent ferritin degradation and elevation of labile iron pool. (PubMed id 17603935)1, 9 Antosiewicz J....Herman-Antosiewicz A. (amp 2007)
    101. Disulfide Bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1 regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosis. (PubMed id 17652454)1, 9 Nadeau P.J....Landry J. (Mol. Biol. Cell 2007)
    102. Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells. (PubMed id 17904874)1, 9 Miyamoto-Yamasaki Y....Yamada K. (Cell Biol. Int. 2007)
    103. Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs. (PubMed id 16569638)1, 9 Nelson K.K....Melendez J.A. (J. Biol. Chem. 2006)
    104. Regulation of JNK by MKK-7 in fibroblast-like synoviocytes. (PubMed id 16802349)1, 9 Inoue T....Firestein G.S. (Arthritis Rheum. 2006)
    105. Preheating accelerates mitogen-activated protein (MAP) kinase inactivation post-heat shock via a heat shock protein 70-mediated increase in phosphorylated MAP kinase phosphatase-1. (PubMed id 15677475)1, 9 Lee K.H....Yoo C.G. (J. Biol. Chem. 2005)
    106. Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun N-terminal kinase. (PubMed id 16038800)1, 9 Cadalbert L....Plevin R. (Cell. Signal. 2005)
    107. c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells. (PubMed id 15890690)1, 9 Gururajan M....Bondada S. (Blood 2005)
    108. Up-regulation of c-Jun-NH2-kinase pathway contributes to the induction of mitochondria-mediated apoptosis by alpha-tocopheryl succinate in human prostate cancer cells. (PubMed id 15657352)1, 9 Zu K....Ip C. (Mol. Cancer Ther. 2005)
    109. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. (PubMed id 15778501)1, 9 Tafolla E....Kapila Y.L. (J. Biol. Chem. 2005)
    110. Angiotensin II activates the human renin promoter in an in vitro model: the role of c-Jun-N-terminal kinase. (PubMed id 15238629)1, 9 Terebessy T....Mucsi I. (Nephrol. Dial. Transplant. 2004)
    111. Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1. (PubMed id 14561739)1, 9 Higuchi H....Gores G.J. (J. Biol. Chem. 2004)
    112. Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. (PubMed id 14504284)1, 9 Figueroa C.... Vojtek A.B. (J. Biol. Chem. 2003)
    113. Subdomain VIII is a specificity-determining region in MEKK1. (PubMed id 14500727)1, 9 Tu Z. and Lee F.S. (J. Biol. Chem. 2003)
    114. Uncoupling of protein kinase D from suppression of EGF-dependent c-Jun phosphorylation in cancer cells. (PubMed id 12646240)1, 9 Hurd C. and Rozengurt E. (Biochem. Biophys. Res. Commun. 2003)
    115. c-Jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells. (PubMed id 12707267)1, 9 Vivo C....Broaddus V.C. (J. Biol. Chem. 2003)
    116. IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition. (PubMed id 11865055)1, 9 Sanna M.G.... Ulevitch R.J. (Mol. Cell. Biol. 2002)
    117. TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. (PubMed id 12296995)1, 9 Lee S.W....Lee Z.H. (J. Biochem. Mol. Biol. 2002)
    118. Dominant negative MEKK1 inhibits survival of pancreatic cancer cells. (PubMed id 12185592)1, 9 Hirano T....Shirasawa H. (Oncogene 2002)
    119. Novel role for JNK as a stress-activated Bcl2 kinase. (PubMed id 11323415)1, 9 Deng X....May W.S. (J. Biol. Chem. 2001)
    120. Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis. (PubMed id 10799874)1, 9 Manna S.K. and Aggarwal B.B. (J. Immunol. 2000)
    121. c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity. (PubMed id 10747973)1, 9 Dai R....Mivechi N.F. (J. Biol. Chem. 2000)
    122. The JIP group of mitogen-activated protein kinase scaffold proteins. (PubMed id 10490659)1, 9 Yasuda J.... Davis R.J. (Mol. Cell. Biol. 1999)
    123. COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. (PubMed id 10585392)1, 9 Naumann M....Dubiel W. (J. Biol. Chem. 1999)
    124. Serine phosphorylation and negative regulation of Stat3 by JNK. (PubMed id 10521505)1, 9 Lim C.P. and Cao X. (J. Biol. Chem. 1999)
    125. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. (PubMed id 9808624)1, 9 Xia Y.... Karin M. (Genes Dev. 1998)
    126. Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. (PubMed id 9020136)1, 9 Janknecht R. and Hunter T. (J. Biol. Chem. 1997)
    127. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. (PubMed id 9162092)1, 9 Deacon K. and Blank J.L. (J. Biol. Chem. 1997)
    128. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. (PubMed id 8001819)1, 9 Kallunki T.... Karin M. (Genes Dev. 1994)
    129. ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells. (PubMed id 20512919)1, 9 Yang M....Liu X. (J. Cell. Biochem. 2010)
    130. JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter. (PubMed id 20116378)1, 9 Rong Y....Shen Y.H. (FEBS Lett. 2010)
    131. A novel c-Jun N-terminal kinase (JNK)-binding protein WDR62 is recruited to stress granules and mediates a nonclassical JNK activation. (PubMed id 19910486)1, 9 Wasserman T....Aronheim A. (Mol. Biol. Cell 2010)
    132. Mixed lineage kinase-3/JNK1 axis promotes migration of human gastric cancer cells following gastrin stimulation. (PubMed id 20150185)1, 9 Mishra P....Rana B. (Mol. Endocrinol. 2010)
    133. Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes. (PubMed id 20173753)1, 9 Manganaro L....Giacca M. (Nat. Med. 2010)
    134. Transforming growth factor-I^1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts. (PubMed id 20142324)1, 9 Jablonska E....Wygrecka M. (J. Biol. Chem. 2010)
    135. Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation. (PubMed id 20018857)1, 9 Desai L.P....Waters C.M. (J. Biol. Chem. 2010)
    136. Involvement of the JNK activation in terbinafine-induced p21 up-regulation and DNA synthesis inhibition in human vascular endothelial cells. (PubMed id 19693773)1, 9 Hsu S.P....Lee W.S. (J. Cell. Biochem. 2009)
    137. Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis. (PubMed id 19801633)1, 9 Ding J....Wang H. (J. Biol. Chem. 2009)
    138. Proteomics and pathway analysis identifies JNK signaling as critical for high linear energy transfer radiation-induced apoptosis in non-small lung cancer cells. (PubMed id 19168796)1, 9 StAYhl S....Viktorsson K. (amp 2009)
    139. Fas-induced apoptosis of renal cell carcinoma is mediated by apoptosis signal-regulating kinase 1 via mitochondrial damage-dependent caspase-8 activation. (PubMed id 19940360)1, 9 Hassan M....Grinstein E. (Cell. Oncol. 2009)
    140. Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines. (PubMed id 19352384)1, 9 Mahalingam D....Szegezdi E. (Br. J. Cancer 2009)
    141. AMP kinase signaling determines whether c-Jun N-terminal kinase promotes survival or apoptosis during glucose deprivation. (PubMed id 19037093)1, 9 Yun H....Ha J. (Carcinogenesis 2009)
    142. Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation. (PubMed id 19194824)1, 9 Li M....Yao Q. (Cancer Invest. 2009)
    143. c-Jun N-terminal kinase regulates apoptosis in endometrial cancer cells. (PubMed id 19424800)1, 9 Reno E.M....Bradford A.P. (Apoptosis 2009)
    144. The TAK1-JNK cascade is required for IRF3 function in the innate immune response. (PubMed id 19153595)1, 9 Zhang B....Wang C. (Cell Res. 2009)
    145. NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner. (PubMed id 19286999)1, 9 Cui Y.X....Turner S.D. (Blood 2009)
    146. Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB. (PubMed id 19074436)1, 9 Wang C....Ling C. (J. Biol. Chem. 2009)
    147. Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling. (PubMed id 19877043)1, 9 Svensson C.I....Firestein G.S. (Arthritis Rheum. 2009)
    148. JNK phosphorylates beta-catenin and regulates adherens junctions. (PubMed id 19667122)1, 9 Lee M.H....Andreadis S.T. (FASEB J. 2009)
    149. Activation of JNK and c-Jun is involved in glucose oxidase-mediated cell death of human lymphoma cells. (PubMed id 19937141)1, 9 Son Y.O....Lee J.C. (Mol. Cells 2009)
    150. Phloretin induces apoptosis in H-Ras MCF10A human breast tumor cells through the activation of p53 via JNK and p38 mitogen-activated protein kinase signaling. (PubMed id 19723092)1, 9 Kim M.S....Lee H.J. (Ann. N. Y. Acad. Sci. 2009)
    151. JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma. (PubMed id 19686584)1, 9 Chang Q....Chen F. (Mol. Cancer 2009)
    152. c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D. (PubMed id 19339050)1, 9 Chen-Deutsch X....Studzinski G.P. (Leuk. Res. 2009)
    153. Hypothermia attenuates ischemia/reperfusion-induced endothelial cell apoptosis via alterations in apoptotic pathways and JNK signaling. (PubMed id 19596001)1, 9 Yang D....Li H. (FEBS Lett. 2009)
    154. SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase. (PubMed id 18055217)1, 9 Miao T....Richardson P.M. (Mol. Cell. Neurosci. 2008)
    155. Sequential activation of protein kinase C delta and JNK is required for interferon-alpha-induced expression of IFIT4. (PubMed id 17933493)1, 9 Huang X....Wen F. (Cell. Signal. 2008)
    156. Expression of pokeweed antiviral protein in mammalian cells activates c-Jun NH2-terminal kinase without causing apoptosis. (PubMed id 18573678)1, 9 Chan Tung K.W....Hudak K.A. (amp 2008)
    157. SHP-1 inhibition by 4-hydroxynonenal activates Jun N-terminal kinase and glutamate cysteine ligase. (PubMed id 18276794)1, 9 Rinna A. and Forman H.J. (Am. J. Respir. Cell Mol. Biol. 2008)
    158. Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin. (PubMed id 17942603)1, 9 Panaretakis T....GrandAcr D. (Mol. Biol. Cell 2008)
    159. Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. (PubMed id 19033664)1, 9 Hui L....Wagner E.F. (J. Clin. Invest. 2008)
    160. Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. (PubMed id 18757369)1, 9 FromiguAc O....Marie P.J. (J. Biol. Chem. 2008)
    161. Low doses of paclitaxel potently induce apoptosis in human retinoblastoma Y79 cells by up-regulating E2F1. (PubMed id 18813780)1, 9 Drago-Ferrante R....Vento R. (Int. J. Oncol. 2008)
    162. Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway. (PubMed id 18815275)1, 9 Jeon Y.J....Chung C.H. (Mol. Biol. Cell 2008)
    163. The hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases. (PubMed id 18387958)1, 9 Kyosseva S.V....Weigel P.H. (J. Biol. Chem. 2008)
    164. Regulation of human beta-defensin-2 by Mycobacterium bovis bacillus Calmette-GuAcrin (BCG): involvement of PKC, JNK, and PI3K in human lung epithelial cell line (A549). (PubMed id 18603327)1, 9 MAcndez-Samperio P....Trejo A. (Peptides 2008)
    165. Active c-jun N-terminal kinase induces caspase cleavage of tau and additional phosphorylation by GSK-3beta is required for tau aggregation. (PubMed id 18540881)1, 9 Sahara N....Takashima A. (Eur. J. Neurosci. 2008)
    166. Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1. (PubMed id 18429822)1, 9 Kato T. Jr.... Ono Y. (Genes Cells 2008)
    167. JNK signaling pathway is required for bFGF-mediated surface cadherin downregulation on HUVEC. (PubMed id 18164704)1, 9 Wu J.C....Kao W.Y. (Exp. Cell Res. 2008)
    168. The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX. (PubMed id 18620777)1, 9 Aderca I....Roberts L.R. (J. Hepatol. 2008)
    169. M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion. (PubMed id 18636174)1, 9 Ono R....Matsushita M. (Int. J. Mol. Med. 2008)
    170. Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. (PubMed id 18286207)1, 9 Blanco S.... Lazo P.A. (PLoS ONE 2008)
    171. Involvement of endoplasmic reticulum stress in Docetaxel-induced JNK-dependent apoptosis of human melanoma. (PubMed id 18989785)1, 9 Mhaidat N.M....Hersey P. (Apoptosis 2008)
    172. p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. (PubMed id 18316600)1, 9 Choi B.H....Shin S.Y. (Cancer Res. 2008)
    173. Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1. (PubMed id 18307971)2, 9 Murata T.... Yokoyama K.K. (Anal. Biochem. 2008)
    174. PP2A regulates upstream members of the c-jun N-terminal kinase mitogen-activated protein kinase signaling pathway. (PubMed id 17693927)1, 9 Zhao B....Shanley T.P. (Shock 2008)
    175. The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. (PubMed id 18547751)1, 9 Hsin Y.H....Chueh P.J. (Toxicol. Lett. 2008)
    176. FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. (PubMed id 18524773)1, 9 Wang I.C....Lau L.F. (J. Biol. Chem. 2008)
    177. Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition. (PubMed id 17699782)1, 9 Wang Q....Evers B.M. (Cancer Res. 2007)
    178. The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt. (PubMed id 16912864)1, 9 Ogunwobi O.O. and Beales I.L. (Int J Colorectal Dis 2007)
    179. Dual targeting of IGF-1R and PDGFR inhibits proliferation in high-grade gliomas cells and induces radiosensitivity in JNK-1 expressing cells. (PubMed id 17568996)1, 9 Carapancea M....Dricu A. (J. Neurooncol. 2007)
    180. Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB. (PubMed id 17626013)1, 9 Suzuki S....Sakurai H. (J. Biol. Chem. 2007)
    181. Regulation of the orphan receptor TR3 nuclear functions by c-Jun N terminal kinase phosphorylation. (PubMed id 17023523)1, 9 Liu B....Wu Q. (Endocrinology 2007)
    182. Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. (PubMed id 17478078)1, 9 Grijelmo C....Gespach C. (Cell. Signal. 2007)
    183. Wiring the cell signaling circuitry by the NF-kappa B and JNK1 crosstalk and its applications in human diseases. (PubMed id 17496921)1, 9 Liu J. and Lin A. (Oncogene 2007)
    184. Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals. (PubMed id 16636664)1, 9 Wu Y....Yin Z. (Oncogene 2006)
    185. c-Jun N-terminal kinase is necessary for platelet-derived growth factor-mediated chemotaxis in primary fibroblasts. (PubMed id 16760468)1, 9 Amagasaki K....Lennartsson J. (J. Biol. Chem. 2006)
    186. Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis. (PubMed id 16972261)1, 9 Ramos A.M....Aller P. (J. Cell. Physiol. 2006)
    187. Decreased expression of phosphorylated JNK in breast infiltrating ductal carcinoma is associated with a better overall survival. (PubMed id 16381010)1, 9 Yeh Y.T....Yuan S.S. (Int. J. Cancer 2006)
    188. Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity. (PubMed id 16283431)1, 9 Huang H.S....Chuang C.H. (J. Biomed. Sci. 2006)
    189. The tyrosine kinase Syk regulates TPL2 activation signals. (PubMed id 16291755)1, 9 Eliopoulos A.G....Tsichlis P.N. (J. Biol. Chem. 2006)
    190. Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways. (PubMed id 16814421)1, 9 Song H. and Moon A. (Neurosci. Res. 2006)
    191. Activation of c-Jun NH2-terminal kinase is required for gemcitabine's cytotoxic effect in human lung cancer H1299 cells. (PubMed id 16307741)1, 9 Teraishi F....Fang B. (FEBS Lett. 2005)
    192. Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. (PubMed id 16260419)1, 9 Zhao K.W....Chen G.Q. (J. Biol. Chem. 2005)
    193. Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor. (PubMed id 15755722)1, 9 Zhang W....Min W. (J. Biol. Chem. 2005)
    194. Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop. (PubMed id 15998799)1, 9 Song J.J. and Lee Y.J. (J. Cell Biol. 2005)
    195. Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways. (PubMed id 14699155)1, 9 Arndt P.G....Worthen G.S. (J. Biol. Chem. 2004)
    196. Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity. (PubMed id 12659851)1, 9 Huang J....Lee F.S. (Biochem. Biophys. Res. Commun. 2003)
    197. Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase. (PubMed id 12902351)1, 9 Onuma M....Iwamoto Y. (J. Biol. Chem. 2003)
    198. Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1. (PubMed id 12917434)1, 9 Scheinfeld M.H....D'Adamio L. (J. Biol. Chem. 2003)
    199. Caspase-mediated cleavage of JNK during stress-induced apoptosis. (PubMed id 12821118)1, 9 Enomoto A....Hosoi Y. (Biochem. Biophys. Res. Commun. 2003)
    200. AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. (PubMed id 12697749)1, 9 Yuan Z.Q....Cheng J.Q. (J. Biol. Chem. 2003)
    201. Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. (PubMed id 12859962)1, 9 Ghosh J. (Biochem. Biophys. Res. Commun. 2003)
    202. ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. (PubMed id 12592382)1, 9 Wen-Sheng W. (Oncogene 2003)
    203. Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways. (PubMed id 12121974)1, 9 Pan Z.Z....Godwin A.K. (J. Biol. Chem. 2002)
    204. The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway. (PubMed id 12138158)1, 9 Chen A.J....Belmont J.W. (J. Biol. Chem. 2002)
    205. Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells: distinct involvement of c-Jun N-terminal kinase in LPS-induced CD44 expression. (PubMed id 12421945)1, 9 Gee K....Kumar A. (J. Immunol. 2002)
    206. A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling. (PubMed id 12058026)1, 9 Holmberg C....Kallunki T. (J. Biol. Chem. 2002)
    207. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1- JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. (PubMed id 12189133)1, 9 Matsuura H.... Ichijo H. (J. Biol. Chem. 2002)
    208. Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. (PubMed id 12023963)1, 9 Xu Y.C....Terada L.S. (J. Biol. Chem. 2002)
    209. Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation. (PubMed id 12351702)1, 9 Itoh M....Imai K. (Mol. Endocrinol. 2002)
    210. Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. (PubMed id 11707464)1, 9 Park H.S....Choi E.J. (J. Biol. Chem. 2002)
    211. SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. (PubMed id 12223491)1, 9 Rui H.L.... Lin S.C. (J. Biol. Chem. 2002)
    212. Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1- induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. (PubMed id 12242293)1, 9 Jiang Z.... Li X. (Mol. Cell. Biol. 2002)
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    214. NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway. (PubMed id 12376548)1, 9 Salehi A.H....Barker P.A. (J. Biol. Chem. 2002)
    215. Differential gene regulation by specific gain-of-function JNK1 proteins expressed in Swiss 3T3 fibroblasts. (PubMed id 12354774)1, 9 Han S.Y....Heasley L.E. (J. Biol. Chem. 2002)
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    217. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. (PubMed id 11283254)1, 9 Buschmann T....Ronai Z. (Mol. Cell. Biol. 2001)
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    219. HIV Tat activates c-Jun amino-terminal kinase through an oxidant-dependent mechanism. (PubMed id 11448159)1, 9 Gu Y....Terada L.S. (Virology 2001)
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    221. Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. (PubMed id 11279232)1, 9 Zhang Y....Dong Z. (J. Biol. Chem. 2001)
    222. HIV type 1 nef gene inhibits tumor necrosis factor alpha-induced apoptosis and promotes cell proliferation through the action of MAPK and JNK in human glial cells. (PubMed id 11153078)1, 9 Robichaud G.A. and Poulin L. (AIDS Res. Hum. Retroviruses 2000)
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    236. Alkylphosphocholines and curcumin induce programmed cell death in cutaneous T-cell lymphoma cell lines. (PubMed id 24225136)1 Yosifov D.Y....Konstantinov S.M. (Leuk. Res. 2014)
    237. Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. (PubMed id 24184208)1 Misheva M....Bogoyevitch M.A. (Biochim. Biophys. Acta 2014)
    238. c-Jun N-terminal kinase is upregulated in patients with hypospadias. (PubMed id 23273084)1 Li M....Wei G. (Urology 2013)
    239. Crosstalk between Fas and JNK determines lymphocyte apoptosis after ionizing radiation. (PubMed id 23662689)1 Praveen K. and Saxena N. (Radiat. Res. 2013)
    240. ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells. (PubMed id 23580093)1 Cai D.T....Qiu Y.H. (Mol. Cell. Biochem. 2013)
    241. Expression and proliferation profiles of PKC, JNK and p38MAPK in physiologically stretched human bladder smooth muscle cells. (PubMed id 23916702)1 Wazir R....Wang K.J. (Biochem. Biophys. Res. Commun. 2013)
    242. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    243. I^1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. (PubMed id 23359252)1 Goel H.L....Languino L.R. (J. Cell. Physiol. 2013)
    244. Hyperactivated JNK is a therapeutic target in pVHL-deficient renal cell carcinoma. (PubMed id 23393199)1 An J....Rettig M.B. (Cancer Res. 2013)
    245. SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase. (PubMed id 23861391)1 Takeshita Y....Matsuoka M. (J. Biol. Chem. 2013)
    246. Asymmetric dimethylarginine attenuates serum starvation-induced apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway. (PubMed id 24091673)1 Li H....Jia W. (amp 2013)
    247. Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway. (PubMed id 23906792)1 Lin C.H....Chen B.C. (Biochim. Biophys. Acta 2013)
    248. RNA interference-mediated FANCF silencing sensitizes OVCAR3 ovarian cancer cells to adriamycin through increased adriamycin-induced apoptosis dependent on JNK activation. (PubMed id 23440494)1 He M....Wei M.J. (Oncol. Rep. 2013)
    249. JNK1I^1 is phosphorylated during expression in E. coli and in vitro by MKK4 at three identical novel sites. (PubMed id 23416355)1 Owen G.R....Dirr H.W. (Biochem. Biophys. Res. Commun. 2013)
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    251. Enhanced redox factor 1 (REF1)-modulated p53 stabilization and JNK1 dissociation in response to selenomethionine. (PubMed id 24023291)1 Jung H.J....Seo Y.R. (Anticancer Res. 2013)
    252. MUC1 activates JNK1 and inhibits apoptosis under genotoxic stress. (PubMed id 24055030)1 Chen Q....Xiao Z.X. (Biochem. Biophys. Res. Commun. 2013)
    253. IL-4 inhibition of IL-1 induced Matrix metalloproteinase-3 (MMP-3) expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun N-terminal kinase (JNK). (PubMed id 23608488)1 Chambers M....Borghaei R.C. (Exp. Cell Res. 2013)
    254. Transglutaminase-2 induces N-cadherin expression in TGF-I^1-induced epithelial mesenchymal transition via c-Jun-N-terminal kinase activation by protein phosphatase 2A down-regulation. (PubMed id 23290789)1 Park M.K....Lee C.H. (Eur. J. Cancer 2013)
    255. Increased expression of p21Waf1/Cip1 and JNK with costimulation of prostate cancer cell activation by an siRNA Egr-1 inhibitor. (PubMed id 23715767)1 Parra E....Ferreira J. (Oncol. Rep. 2013)
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    257. JNK1/2 regulates ER-mitochondrial Ca2+ cross-talk during IL-1I^-mediated cell death in RINm5F and human primary I^-cells. (PubMed id 23615449)1 Verma G....Datta M. (Mol. Biol. Cell 2013)
    258. Differential roles of JNK, ERK1/2, and p38 mitogen-activated protein kinases on endothelial cell tissue repair functions in response to tumor necrosis factor-I+. (PubMed id 23258237)1 Kanaji N....Liu X. (J. Vasc. Res. 2013)
    259. The activation of HMGB1 as a progression factor on inflammation response in normal human bronchial epithelial cells through RAGE/JNK/NF-I_B pathway. (PubMed id 23712703)1 Wu X....Shang C. (Mol. Cell. Biochem. 2013)
    260. The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex. (PubMed id 23770673)1 van den Berg M.C....Burgering B.M. (J. Biol. Chem. 2013)
    261. Expression of NFkB1, GADD45A and JNK1 in salivary gland carcinomas of different histotypes. (PubMed id 23603344)1 Gobel G....Gombos K. (amp 2013)
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    280. Extracellular HIV-1 Tat induces human beta-defensin-2 production via NF-kappaB/AP-1 dependent pathways in human B cells. (PubMed id 22450687)1 Ju S.M....Park J. (Mol. Cells 2012)
    281. c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates PolI^ recruitment to stalled replication forks. (PubMed id 22456510)1 Barkley L.R....Vaziri C. (Mol. Biol. Cell 2012)
    282. PKCI+ inhibited apoptosis by decreasing the activity of JNK in MCF-7/ADR cells. (PubMed id 21106355)1 Wang N....Xie F. (Exp. Toxicol. Pathol. 2012)
    283. Attenuation of TNFSF10/TRAIL-induced apoptosis by an autophagic survival pathway involving TRAF2- and RIPK1/RIP1-mediated MAPK8/JNK activation. (PubMed id 23051914)1 He W....Lin Y. (Autophagy 2012)
    284. Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species. (PubMed id 23056263)1 Kim T.H....Wang R.S. (PLoS ONE 2012)
    285. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    286. BLyS expression and JNK activation may form a feedback loop to promote survival and proliferation of multiple myeloma cells. (PubMed id 22850273)1 Xu G....Ju S.Q. (Cytokine 2012)
    287. Stress-activated kinase pathway alteration is a frequent event in bladder cancer. (PubMed id 22154358)1 Otto K.B....Robinson V.L. (Urol. Oncol. 2012)
    288. Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the activation of the c-Jun N-terminal protein kinase signaling pathway. (PubMed id 23077074)1 Laviola L....Giorgino F. (Endocrinology 2012)
    289. Estrogen regulates JNK1 genomic localization to control gene expression and cell growth in breast cancer cells. (PubMed id 22446103)1 Sun M....Kraus W.L. (Mol. Endocrinol. 2012)
    290. Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway. (PubMed id 22729748)1 An J....Tang Y. (Biotechnol. Lett. 2012)
    291. Ganoderma lucidum polysaccharides prevent platelet-derived growth factor-stimulated smooth muscle cell proliferation in vitro and neointimal hyperplasia in the endothelial-denuded artery in vivo. (PubMed id 22021110)1 Wang S.H....Chen Y.L. (J. Cell. Physiol. 2012)
    292. Inhibition of JNK-1 by small interfering RNA induces apoptotic signaling in PC-3 prostate cancer cells. (PubMed id 22766602)1 Parra E. (Int. J. Mol. Med. 2012)
    293. Impact of JNK1, JNK2, and ligase Itch on reactive oxygen species formation and survival of prostate cancer cells treated with diallyl trisulfide. (PubMed id 21863240)1 Sielicka-Dudzin A....Antosiewicz J. (Eur J Nutr 2012)
    294. Role of JNK-1 regulation in the protection of contact-inhibited fibroblasts from oxidative stress. (PubMed id 21822690)1 Gaballah M....Hutter-Lobo D. (Mol. Cell. Biochem. 2012)
    295. JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27(Kip1) phosphorylation. (PubMed id 22014979)1 Kim H....Lee J.W. (Cancer Lett. 2012)
    296. Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef. (PubMed id 22844345)1 Saxena S.K....Nair M.P. (Future Virol 2012)
    297. Effect of HSP70 and 90 in modulation of JNK, ERK expression in preeclamptic placental endothelial cell. (PubMed id 22689214)1 Padmini E....Lavanya S. (Cell Biochem. Biophys. 2012)
    298. Activation of estrogen receptor I+ by raloxifene through an activating protein-1-dependent tethering mechanism in human cervical epithelial cancer cells: a role for c-Jun N-terminal kinase. (PubMed id 21964465)1 Fogarty E.A....Kraus W.L. (Mol. Cell. Endocrinol. 2012)
    299. Increased JNK1 signaling pathway is responsible for ABCG2-mediated multidrug resistance in human colon cancer. (PubMed id 22870247)1 Zhu M.M....Ran Z.H. (PLoS ONE 2012)
    300. Wnt5a activates THP-1 monocytic cells via a I^-catenin-independent pathway involving JNK and NF-I_B activation. (PubMed id 22763043)1 Kim J....Lee I. (Cytokine 2012)
    301. Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing. (PubMed id 22363806)1 Shi L....Wu X. (PLoS ONE 2012)
    302. c-Jun N-terminal kinase is required for thermotherapy-induced apoptosis in human gastric cancer cells. (PubMed id 23326144)1 Xiao F....Zhu Q.X. (World J. Gastroenterol. 2012)
    303. Enzyme kinetics and interaction studies for human JNK1I^1 and substrates activating transcription factor 2 (ATF2) and c-Jun N-terminal kinase (c-Jun). (PubMed id 22351776)1 Figuera-Losada M. and LoGrasso P.V. (J. Biol. Chem. 2012)
    304. Seven cysteine-deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1. (PubMed id 23020677)1 Nakaniwa T....Kinoshita T. (Biochemistry 2012)
    305. Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation. (PubMed id 22493283)1 Kwak D.... Ryu S.H. (J. Biol. Chem. 2012)
    306. [Effect of different concentrations of bortezomib on the expression of ERK, JNK and P38 in daunorubicin-resistant K562 cells]. (PubMed id 21729547)1 Fu B.B....Liu Z.G. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011)
    307. Crosstalk between JNK and SUMO signaling pathways: deSUMOylation is protective against H2O2-induced cell injury. (PubMed id 22164242)1 Feligioni M....Borsello T. (PLoS ONE 2011)
    308. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    309. NF-I_B, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and Ga88/M cell cycle arrest. (PubMed id 22005259)1 Yin Y....Zou G. (Food Chem. Toxicol. 2011)
    310. Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just AKT inhibition. (PubMed id 21775054)1 Sun H....Li J. (Cancer Lett. 2011)
    311. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    312. Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells. (PubMed id 21095239)2 Deng H.... Lin A. (Int. J. Biochem. Cell Biol. 2011)
    313. JNK1 is required for lentivirus entry and gene transfer. (PubMed id 21191018)1 Lee M.H....Andreadis S.T. (J. Virol. 2011)
    314. Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation. (PubMed id 21757743)1 Ben-Ami I....Seger R. (J. Biol. Chem. 2011)
    315. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    316. Role of FGD1, a Cdc42 guanine nucleotide exchange factor, in epidermal growth factor-stimulated c-Jun NH2-terminal kinase activation and cell migration. (PubMed id 21212517)1 Oshima T....Hayakawa M. (amp 2011)
    317. Mitochondrial c-Jun N-terminal kinase (JNK) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation. (PubMed id 21454558)1 Chambers J.W. and LoGrasso P.V. (J. Biol. Chem. 2011)
    318. [Hyperactivation of c-Jun NH(2)-terminal protein kinase contributes to the proliferation of B lymphoma cells]. (PubMed id 21362231)1 Guo Y.Y....Zhang J.Y. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011)
    319. Interaction of profilin-1 and F-actin via a I^-arrestin-1/JNK signaling pathway involved in prostaglandin E(2)-induced human mesenchymal stem cells migration and proliferation. (PubMed id 20717968)1 Yun S.P....Han H.J. (J. Cell. Physiol. 2011)
    320. GST pi modulates JNK activity through a direct interaction with JNK substrate, ATF2. (PubMed id 21384452)1 ThAcvenin A.F....Colman R.F. (Protein Sci. 2011)
    321. A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases. (PubMed id 21483469)1 Malik S....Seth P. (PLoS ONE 2011)
    322. Oscillatory shear stress induces mitochondrial superoxide production: implication of NADPH oxidase and c-Jun NH2-terminal kinase signaling. (PubMed id 20919940)1 Takabe W....Hsiai T.K. (amp 2011)
    323. Nox2-based NADPH oxidase mediates HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 and subsequent monocyte adhesion in human astrocytes. (PubMed id 21172429)1 Song H.Y....Park J. (amp 2011)
    324. Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells. (PubMed id 21817106)1 Shi Y....LA1scher T.F. (Arterioscler. Thromb. Vasc. Biol. 2011)
    325. Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor. (PubMed id 21930785)1 Chandrasekaran S....Cook J.G. (Mol. Cell. Biol. 2011)
    326. Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis. (PubMed id 21237154)1 Vaishnav M....Dickens M. (Exp. Cell Res. 2011)
    327. PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic I^-cell apoptosis via regulation of the BH3-only protein Bim. (PubMed id 21984578)1 Santin I....Eizirik D.L. (Diabetes 2011)
    328. Role of phosphorylation in the nuclear biology of HIV-1. (PubMed id 21651489)1 Francis A.C....Cereseto A. (Curr. Med. Chem. 2011)
    329. G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion. (PubMed id 22087220)1 Juneja J....Casey P.J. (PLoS ONE 2011)
    330. Peroxiredoxin II restrains DNA damage-induced death in cancer cells by positively regulating JNK-dependent DNA repair. (PubMed id 21148313)1 Lee K.W....Kang S.W. (J. Biol. Chem. 2011)
    331. Increased JNK1 activity contributes to the upregulation of ApoD in the apocrine secretory gland cells from axillary osmidrosis. (PubMed id 21526344)1 Chen H....Li X. (Mol. Cell. Biochem. 2011)
    332. Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-I_B inhibitors in ovarian cancer therapy. (PubMed id 21931671)1 Zerbini L.F....Libermann T.A. (PLoS ONE 2011)
    333. Inhibition of JNK1 expression decreases migration and invasion of mouse hepatocellular carcinoma cell line in vitro. (PubMed id 20490718)1 Zhang Y.H....Tang J.W. (Med. Oncol. 2011)
    334. Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. (PubMed id 21156789)1 Prasad S....Aggarwal B.B. (J. Biol. Chem. 2011)
    335. Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK/JNK-dependent activation of NF-I_B in THP-1 cells. (PubMed id 21752354)1 Lee S.M....Lee W.H. (Cell. Immunol. 2011)
    336. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    337. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    338. The MYND domain-containing protein BRAM1 inhibits lymphotoxin beta receptor-mediated signaling through affecting receptor oligomerization. (PubMed id 20732415)1 Liu H.P....Chang Y.S. (Cell. Signal. 2011)
    339. IL-17R activation of human periodontal ligament fibroblasts induces IL-23 p19 production: Differential involvement of NF-I_B versus JNK/AP-1 pathways. (PubMed id 21145111)1 Zhu L....Peng B. (Mol. Immunol. 2011)
    340. The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo. (PubMed id 22114267)1 Mazzitelli S....Tournier C. (J. Neurosci. 2011)
    341. Deactivation of STAT6 through serine 707 phosphorylation by JNK. (PubMed id 21123173)1 Shirakawa T....Uesugi M. (J. Biol. Chem. 2011)
    342. The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. (PubMed id 21524306)1 Reyes-Zurita F.J....LupiA!A+ez J.A. (BMC Cancer 2011)
    343. HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species. (PubMed id 21483669)1 Zhu D.M....Zheng D. (PLoS ONE 2011)
    344. Oxidized low density lipoprotein induces cyclin A synthesis. Involvement of ERK, JNK and NFkappaB. (PubMed id 21764057)1 MaziA"re C....MaziA"re J.C. (Atherosclerosis 2011)
    345. NF-I_B feedback control of JNK1 activation modulates TRPV1-induced increases in IL-6 and IL-8 release by human corneal epithelial cells. (PubMed id 22171160)1 Wang Z....Reinach P.S. (Mol. Vis. 2011)
    346. Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides. (PubMed id 21697181)1 Yue W.Y....Hansen M.R. (Neuro-oncology 2011)
    347. Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes. (PubMed id 21444723)1 Pillai V.B....Gupta M.P. (Mol. Cell. Biol. 2011)
    348. Breast cancer cells proliferation is regulated by tyrosine phosphatase SHP1 through c-jun N-terminal kinase and cooperative induction of RFX-1 and AP-4 transcription factors. (PubMed id 21719561)1 Amin S....Kozlowski M. (Mol. Cancer Res. 2011)
    349. Protective effect of kobophenol A on nitric oxide-induced cell apoptosis in human osteoblast-like MG-63 cells: involvement of JNK, NF-I_B and AP-1 pathways. (PubMed id 21511059)1 Lee S.R....Pyo S. (Int. Immunopharmacol. 2011)
    350. HIV-1 Tat-mediated induction of platelet-derived growth factor in astrocytes: role of early growth response gene 1. (PubMed id 21368226)1 Bethel-Brown C....Buch S. (J. Immunol. 2011)
    351. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    352. A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation. (PubMed id 21223552)1 Castro J....Benito A. (BMC Cancer 2011)
    353. PTH regulates myleoid ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway. (PubMed id 21465527)1 Kim B.G....Cho J.Y. (J. Cell. Biochem. 2011)
    354. c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells. (PubMed id 21943220)1 Sun T....Zhu X. (J Transl Med 2011)
    355. Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1. (PubMed id 21378396)1 Yu Y. and Richardson D.R. (J. Biol. Chem. 2011)
    356. Dyrk1A Positively Stimulates ASK1-JNK Signaling Pathway during Apoptotic Cell Death. (PubMed id 22110360)1 Choi H.K. and Chung K.C. (Exp Neurobiol 2011)
    357. Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells. (PubMed id 21504622)1 Chiu S.C....Pang C.Y. (BMC Cancer 2011)
    358. Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway. (PubMed id 21134350)1 Norlin M....Wikvall K. (Arch. Biochem. Biophys. 2011)
    359. Inhibition of c-Jun N-terminal kinase attenuates low shear stress-induced atherogenesis in apolipoprotein E-deficient mice. (PubMed id 21629969)1 Wang J....Zhang M.X. (Mol. Med. 2011)
    360. c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK. (PubMed id 21439937)1 Schreck I....Weiss C. (Biochem. Biophys. Res. Commun. 2011)
    361. MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation. (PubMed id 21152872)1 Sun B.K....Song J.J. (Oncol. Rep. 2011)
    362. Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis. (PubMed id 21768777)1 Bates D.J....Eastman A. (amp 2011)
    363. Targeting of tumor necrosis factor receptor 1 to low density plasma membrane domains in human endothelial cells. (PubMed id 20511226)1 D'Alessio A....Pober J.S. (J. Biol. Chem. 2010)
    364. c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis. (PubMed id 20056910)1 Chaudhury H....Evans P.C. (Arterioscler. Thromb. Vasc. Biol. 2010)
    365. p21(Cip1) up-regulated during histone deacetylase inhibitor-induced CD4(+) T-cell anergy selectively associates with mitogen-activated protein kinases. (PubMed id 20102411)1 Selma Dagtas A. and Gilbert K.M. (Immunology 2010)
    366. The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1. (PubMed id 20130137)1 Lu X....Zhou Y. (J. Gen. Virol. 2010)
    367. 8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK. (PubMed id 20632440)1 Yang X.H....Lv Y. (World J. Gastroenterol. 2010)
    368. High glucose induces apoptosis in AC16 human cardiomyocytes via macrophage migration inhibitory factor and c-Jun N-terminal kinase. (PubMed id 20573157)1 Liang J.L....Yu X.Y. (amp 2010)
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    370. Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation. (PubMed id 20510162)1 Kim G....Kim S. (Biochem. Biophys. Res. Commun. 2010)
    371. TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling. (PubMed id 20194509)1 Li M....Li L. (J. Biol. Chem. 2010)
    372. The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. (PubMed id 20647313)1 Gao D....Li J. (J. Biol. Chem. 2010)
    373. c-Jun regulates shear- and injury-inducible Egr-1 expression, vein graft stenosis after autologous end-to-side transplantation in rabbits, and intimal hyperplasia in human saphenous veins. (PubMed id 19940138)1 Ni J....Khachigian L.M. (J. Biol. Chem. 2010)
    374. Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation. (PubMed id 20060003)1 Han Y....Yan C. (J. Mol. Cell. Cardiol. 2010)
    375. DNA damage during mitosis invokes a JNK-mediated stress response that leads to cell death. (PubMed id 20512932)1 Ho C.Y. and Li H.Y. (J. Cell. Biochem. 2010)
    376. JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells. (PubMed id 20483637)1 Utsugi M....Mori M. (Cytokine 2010)
    377. c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL. (PubMed id 21172010)1 Fu L....Sun S.Y. (Mol. Cancer 2010)
    378. Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways. (PubMed id 19802005)1 van Amerongen R....Berns A. (Oncogene 2010)
    379. Oxidized low-density lipoprotein-activated c-Jun NH2-terminal kinase regulates manganese superoxide dismutase ubiquitination: implication for mitochondrial redox status and apoptosis. (PubMed id 20139358)1 Takabe W....Hsiai T.K. (Arterioscler. Thromb. Vasc. Biol. 2010)
    380. Interplay between Cdh1 and JNK activity during the cell cycle. (PubMed id 20581839)1 Gutierrez G.J....Ronai Z.A. (Nat. Cell Biol. 2010)
    381. Jun amino-terminal kinase 1 activation promotes cell survival in ErbB2-positive breast cancer. (PubMed id 20944115)1 Han J.S. and Crowe D.L. (Anticancer Res. 2010)
    382. Phosphorylated c-Jun NH2-terminal kinase is overexpressed in human papillary thyroid carcinomas and associates with lymph node metastasis. (PubMed id 20138424)1 Wang X....Li X. (Cancer Lett. 2010)
    383. Increase of RhoB in gamma-radiation-induced apoptosis is regulated by c-Jun N-terminal kinase in Jurkat T cells. (PubMed id 19995557)1 Kim C.H....Chung K.S. (Biochem. Biophys. Res. Commun. 2010)
    384. CRK adaptor protein expression is required for efficient replication of avian influenza A viruses and controls JNK-mediated apoptotic responses. (PubMed id 20088952)1 Hrincius E.R....Ehrhardt C. (Cell. Microbiol. 2010)
    385. Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation. (PubMed id 20457808)1 Wu R.F....Terada L.S. (Mol. Cell. Biol. 2010)
    386. Polymeric immunoglobulin receptor-mediated invasion of Streptococcus pneumoniae into host cells requires a coordinate signaling of SRC family of protein-tyrosine kinases, ERK, and c-Jun N-terminal kinase. (PubMed id 20829350)1 Agarwal V....Hammerschmidt S. (J. Biol. Chem. 2010)
    387. Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase. (PubMed id 20648623)1 Dasgupta J....Melendez J.A. (J. Cell. Physiol. 2010)
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    389. Control of TrkA-induced cell death by JNK activation and differential expression of TrkA upon DNA damage. (PubMed id 20680486)1 Jung E.J. and Kim D.R. (Mol. Cells 2010)
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    391. TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase. (PubMed id 20070945)1 Su L.T....Runnels L.W. (J. Mol. Biol. 2010)
    392. The PEA-15 protein regulates autophagy via activation of JNK. (PubMed id 20452983)1 BAPck B.C....Roth W. (J. Biol. Chem. 2010)
    393. The oncogenic and growth-suppressive functions of the integrin-linked kinase are distinguished by JNK1 expression in human cancer cells. (PubMed id 20495362)1 Durbin A.D....Malkin D. (Cell Cycle 2010)
    394. Chlamydia pneumoniae disturbs cholesterol homeostasis in human THP-1 macrophages via JNK-PPARI^ dependent signal transduction pathways. (PubMed id 20870032)1 Liu W....Wan J.J. (Microbes Infect. 2010)
    395. Inhibiting TRAF2-mediated activation of NF-kappaB facilitates induction of AP-1. (PubMed id 20133937)1 Manna S.K....Sureshkumar C. (J. Biol. Chem. 2010)
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    399. Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. (PubMed id 20103647)1 Puissant A....Auberger P. (Cancer Res. 2010)
    400. Betuletol 3-methyl ether induces G(2)-M phase arrest and activates the sphingomyelin and MAPK pathways in human leukemia cells. (PubMed id 19676104)1 Rubio S....EstAcvez F. (Mol. Carcinog. 2010)
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    404. Mechanisms of HIV envelope-induced T lymphocyte apoptosis. (PubMed id 20960177)1 Wan Z.T. and Chen X.L. (Virol Sin 2010)
    405. Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. (PubMed id 20086174)1 Romano D.... Kolch W. (Cancer Res. 2010)
    406. Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade. (PubMed id 20336759)1 Yang Y....Lu Y. (J. Med. Virol. 2010)
    407. Effects of UVA on TNF-alpha, IL-1beta, and IL-10 expression levels in human keratinocytes and intervention studies with an antioxidant and a JNK inhibitor. (PubMed id 20070836)1 An L....Liu Y. (amp 2010)
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    409. Livin abrogates apoptosis of SPC-A1 cell by regulating JNKI signaling pathway. (PubMed id 19690982)1 Chen Y.S....Lin L.F. (Mol. Biol. Rep. 2010)
    410. Induction of mitogen-activated protein kinases is proportional to the amount of pressure overload. (PubMed id 19901160)1 Esposito G....Chiariello M. (Hypertension 2010)
    411. DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. (PubMed id 20878914)1 Shao L....Weyand C.M. (EMBO Mol Med 2010)
    412. Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways. (PubMed id 20483734)1 Shan L....Gounni A.S. (J. Immunol. 2010)
    413. p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells. (PubMed id 21187925)1 Spallarossa P....Brunelli C. (PLoS ONE 2010)
    414. Regulation of multidrug resistance protein 1 by tumor necrosis factor alpha in cultured glial cells: involvement of nuclear factor-kappaB and c-Jun N-terminal kinase signaling pathways. (PubMed id 20051532)1 Ronaldson P.T....Bendayan R. (Mol. Pharmacol. 2010)
    415. JNK/ATF2 pathway is involved in iodinated contrast media-induced apoptosis. (PubMed id 19923798)1 Lee H.C....Chang J.G. (Am. J. Nephrol. 2010)
    416. GnRH I and II up-regulate MMP-26 expression through the JNK pathway in human cytotrophoblasts. (PubMed id 20074375)1 Liu J....Wang Y.L. (amp 2010)
    417. DUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt's lymphoma. (PubMed id 20551953)1 Lee S....Crook T. (Br. J. Cancer 2010)
    418. Protein kinase C activation stabilizes LDL receptor mRNA via the JNK pathway in HepG2 cells. (PubMed id 18936517)1 Vargas N.B....Wilson G.M. (J. Lipid Res. 2009)
    419. Dynasore, a dynamin inhibitor, induces PAI-1 expression in MeT-5A human pleural mesothelial cells. (PubMed id 18978303)1 Chung C.L....Hsiao G. (Am. J. Respir. Cell Mol. Biol. 2009)
    420. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (Mol. Cell. Proteomics 2009)
    421. c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists. (PubMed id 19567513)1 FernA!ndez-Veledo S....Lorenzo M. (J. Clin. Endocrinol. Metab. 2009)
    422. Up-regulation of SEPT9_v1 stabilizes c-Jun-N-terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells. (PubMed id 19071215)1 Gonzalez M.E....Petty E.M. (Cell. Signal. 2009)
    423. Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts. (PubMed id 19248119)1 Mun S.H....Choi W.S. (Arthritis Rheum. 2009)
    424. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    425. Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation. (PubMed id 18495129)1 Xia M....Ye Q. (Atherosclerosis 2009)
    426. SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. (PubMed id 18681908)1 Cao C....Wan Y. (J. Cell. Mol. Med. 2009)
    427. Involvement of c-Abl, p53 and the MAP kinase JNK in the cell death program initiated in A2E-laden ARPE-19 cells by exposure to blue light. (PubMed id 19052872)1 Westlund B.S....Sparrow J.R. (Apoptosis 2009)
    428. Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. (PubMed id 19815509)1 Liu J....Lin A. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    429. A selective small-molecule inhibitor of c-Jun N-terminal kinase 1. (PubMed id 19527717)1 Yao K....Dong Z. (FEBS Lett. 2009)
    430. Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode. (PubMed id 19418584)1 Lin R.Y....Richert L. (World J. Gastroenterol. 2009)
    431. FGF2 stimulates the proliferation of human mesenchymal stem cells through the transient activation of JNK signaling. (PubMed id 19664626)1 Ahn H.J....Kwon Y.D. (FEBS Lett. 2009)
    432. Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis. (PubMed id 19723627)1 Tang F....Xiang J. (J. Biol. Chem. 2009)
    433. Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation. (PubMed id 19154785)1 Li R....Hsiai T. (amp 2009)
    434. Enediyne lidamycin induces apoptosis in human multiple myeloma cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase. (PubMed id 19468799)1 Zhen Y.Z....Zhen Y.S. (Int. J. Hematol. 2009)
    435. Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cells. (PubMed id 19574423)1 Desai L.P....Waters C.M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009)
    436. IL-1 beta induces urokinase-plasminogen activator expression and cell migration through PKC alpha, JNK1/2, and NF-kappaB in A549 cells. (PubMed id 19097143)1 Cheng C.Y....Yang C.M. (J. Cell. Physiol. 2009)
    437. Mechanical force induces type I collagen expression in human periodontal ligament fibroblasts through activation of ERK/JNK and AP-1. (PubMed id 19206162)1 Kook S.H....Lee J.C. (J. Cell. Biochem. 2009)
    438. JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma. (PubMed id 19478459)1 Durbin A.D....Malkin D. (J. Clin. Invest. 2009)
    439. Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1/2) and JNK. (PubMed id 19822148)1 Goven D....Bonay M. (FEBS Lett. 2009)
    440. [JNK signaling in osteoblast differentiation]. (PubMed id 19803394)1 Matsuguchi T. (Seikagaku 2009)
    441. Basal cancer cell survival involves JNK2 suppression of a novel JNK1/c-Jun/Bcl-3 apoptotic network. (PubMed id 19806201)1 Ahmed S.U. and Milner J. (PLoS ONE 2009)
    442. Characterization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes. (PubMed id 19695707)1 Valle-Rios R....Ortiz-Navarrete V. (Mol. Immunol. 2009)
    443. Cocaine and human immunodeficiency virus type 1 gp120 mediate neurotoxicity through overlapping signaling pathways. (PubMed id 19319745)1 Yao H....Buch S. (J. Neurovirol. 2009)
    444. Heat shock protein 90 is important for Sp1 stability during mitosis. (PubMed id 19245816)1 Wang S.A....Hung J.J. (J. Mol. Biol. 2009)
    445. Basic fibroblast growth factor upregulates adrenomedullin expression in ovarian epithelial carcinoma cells via JNK-AP-1 pathway. (PubMed id 19616043)1 Zhang Y....Zhao Y. (Regul. Pept. 2009)
    446. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. (PubMed id 19234442)1 Cook P.J.... Rosenfeld M.G. (Nature 2009)
    447. Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation. (PubMed id 19862774)1 Wu W.L....Lai J.H. (Eur. J. Immunol. 2009)
    448. PKCeta confers protection against apoptosis by inhibiting the pro-apoptotic JNK activity in MCF-7 cells. (PubMed id 19523467)1 Rotem-Dai N....Livneh E. (Exp. Cell Res. 2009)
    449. HIV-1 Tat co-operates with IFN-gamma and TNF-alpha to increase CXCL10 in human astrocytes. (PubMed id 19479051)1 Williams R....Buch S.J. (PLoS ONE 2009)
    450. Crystal structure of SCCA1 and insight about the interaction with JNK1. (PubMed id 19166818)2 Zheng B.... Sugiyama M. (Biochem. Biophys. Res. Commun. 2009)
    451. Caveolin-1 acts as a tumor suppressor by down-regulating epidermal growth factor receptor-mitogen-activated protein kinase signaling pathway in pancreatic carcinoma cell lines. (PubMed id 19893453)1 Han F....Zhu H. (Pancreas 2009)
    452. Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body Insulin sensitivity. (PubMed id 19351724)1 BlA1her M....Rudich A. (J. Clin. Endocrinol. Metab. 2009)
    453. The role of c-Jun N-terminal kinases 1/2 in transforming growth factor beta(1)-induced expression of connective tissue growth factor and scar formation in the cornea. (PubMed id 19589256)1 Chang Y. and Wu X.Y. (J. Int. Med. Res. 2009)
    454. Extracellular HIV-1 Tat up-regulates expression of matrix metalloproteinase-9 via a MAPK-NF-kappaB dependent pathway in human astrocytes. (PubMed id 19287189)1 Ju S.M....Park J. (amp 2009)
    455. HIV-1 Vpr: a closer look at the multifunctional protein from the structural perspective. (PubMed id 19275580)1 Pandey R.C....Sawaya B.E. (Curr. HIV Res. 2009)
    456. Expression of the Bcl-2 protein BAD promotes prostate cancer growth. (PubMed id 19593445)1 Smith A.J....Kulik G. (PLoS ONE 2009)
    457. Control of p53 multimerization by Ubc13 is JNK-regulated. (PubMed id 19651615)1 Topisirovic I....Ronai Z.A. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    458. MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability. (PubMed id 19822666)1 Densham R.M....Olson M.F. (Mol. Cell. Biol. 2009)
    459. AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor- induced ASK1-JNK activation. (PubMed id 18292600)1 Min W....Chen H. (Circ. Res. 2008)
    460. Tie2-R849W mutant in venous malformations chronically activates a functional STAT1 to modulate gene expression. (PubMed id 18401423)1 Hu H.T....Wu L.W. (J. Invest. Dermatol. 2008)
    461. Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase. (PubMed id 18845538)1 Liu M....Zhou J. (J. Biol. Chem. 2008)
    462. Inhibition of MITF and tyrosinase by paeonol-stimulated JNK/SAPK to reduction of phosphorylated CREB. (PubMed id 18457359)1 Bu J....Li C.R. (Am. J. Chin. Med. 2008)
    463. Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis. (PubMed id 18723442)1 Zakkar M....Evans P.C. (Circ. Res. 2008)
    464. MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells. (PubMed id 18253836)1 Roduit R. and Schorderet D.F. (Apoptosis 2008)
    465. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. (PubMed id 19036714)1 Ongusaha P.P.... Lee S.W. (Sci. Signal. 2008)
    466. NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. (PubMed id 18219313)1 Tattoli I.... Girardin S.E. (EMBO Rep. 2008)
    467. Cross talk of signaling pathways in the regulation of the glucocorticoid receptor function. (PubMed id 18337589)1 Davies L....Krstic-Demonacos M. (Mol. Endocrinol. 2008)
    468. JNK modulates the effect of caspases and NF-kappaB in the TNF-alpha-induced down-regulation of Na+/K+ATPase in HepG2 cells. (PubMed id 18348163)1 Kassardjian A. and Kreydiyyeh S.I. (J. Cell. Physiol. 2008)
    469. C-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation. (PubMed id 18218857)1 Adhikary G....Pearlman E. (J. Leukoc. Biol. 2008)
    470. Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. (PubMed id 18082745)1 Puri P....Sanyal A.J. (Gastroenterology 2008)
    471. Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. (PubMed id 18212053)1 Endo Y....Rubin J.S. (Mol. Cell. Biol. 2008)
    472. The beta1 integrin activates JNK independent of CagA, and JNK activation is required for Helicobacter pylori CagA+-induced motility of gastric cancer cells. (PubMed id 18356158)1 Snider J.L....Cardelli J.A. (J. Biol. Chem. 2008)
    473. MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway. (PubMed id 18782768)1 Ha U.H....Li J.D. (J. Biol. Chem. 2008)
    474. Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1. (PubMed id 18957422)1 Higashimoto T....Zandi E. (J. Biol. Chem. 2008)
    475. JNK mediates UVB-induced apoptosis upstream lysosomal membrane permeabilization and Bcl-2 family proteins. (PubMed id 18651223)1 Bivik C. and Ollinger K. (Apoptosis 2008)
    476. Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin. (PubMed id 18667537)1 Kuo L.H....Liao Y.F. (Mol. Biol. Cell 2008)
    477. Histone-like DNA binding protein of Streptococcus intermedius induces the expression of pro-inflammatory cytokines in human monocytes via activation of ERK1/2 and JNK pathways. (PubMed id 17883418)1 Liu D....Miyake Y. (Cell. Microbiol. 2008)
    478. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    479. Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells. (PubMed id 18663379)1 Mao X....Li W.X. (Cell Res. 2008)
    480. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. (PubMed id 19054851)2 Goshima N.... Nomura N. (Nat. Methods 2008)
    481. Basal c-Jun N-terminal kinases promote mitotic progression through histone H3 phosphorylation. (PubMed id 18256527)1 Lee K. and Song K. (Cell Cycle 2008)
    482. JNK-mediated phosphorylation of paxillin in adhesion assembly and tension-induced cell death by the adenovirus death factor E4orf4. (PubMed id 18818208)1 Smadja-LamA"re N....Lavoie J.N. (J. Biol. Chem. 2008)
    483. CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK. (PubMed id 18087676)1 Huang J....Qiu X. (Cell. Mol. Life Sci. 2008)
    484. Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. (PubMed id 18769111)1 Wei Y....Levine B. (Autophagy 2008)
    485. Involvement of connexin 43 in angiotensin II-induced migration and proliferation of saphenous vein smooth muscle cells via the MAPK-AP-1 signaling pathway. (PubMed id 18405916)1 Jia G....Agrawal D.K. (J. Mol. Cell. Cardiol. 2008)
    486. [Changes of phospho-JNK expression during the skin burned wound healing]. (PubMed id 18979912)1 Xiong C.Y....Zhu B.L. (Fa Yi Xue Za Zhi 2008)
    487. Histamine induces Egr-1 expression in human aortic endothelial cells via the H1 receptor-mediated protein kinase Cdelta-dependent ERK activation pathway. (PubMed id 18682391)1 Hao F....Cui M.Z. (J. Biol. Chem. 2008)
    488. Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. (PubMed id 18199680)1 Chuang J.-Y....Hung J.-J. (Mol. Biol. Cell 2008)
    489. Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells. (PubMed id 18325654)1 Wang S.F....Lee H.C. (Toxicology 2008)
    490. The toxic effect of pyrrolizidine alkaloid clivorine on the human embryonic kidney 293 cells and its primary mechanism. (PubMed id 18249102)1 Ji L.L....Wang Z.T. (Exp. Toxicol. Pathol. 2008)
    491. Downregulation of cyclin D1-CDK4 protein in human embryonic lung fibroblasts (HELF) induced by silica is mediated through the ERK and JNK pathway. (PubMed id 18703151)1 Shen F....Shi X. (Cell Biol. Int. 2008)
    492. [Synergistic effect of thermotherapy in combination with chemotherapy on lung tumor A549 cells growth through activation of c-Jun N-terminal kinase and inhibition of heat shock protein70 expression]. (PubMed id 19069644)1 Gao S....Zhou F. (Wei Sheng Yan Jiu 2008)
    493. Protease-activated receptor (PAR)-induced interleukin-8 production in airway epithelial cells requires activation of MAP kinases p44/42 and JNK. (PubMed id 18086557)1 Ostrowska E. and Reiser G. (Biochem. Biophys. Res. Commun. 2008)
    494. Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. (PubMed id 18594007)1 Chen T.H....Teng C.M. (Clin. Cancer Res. 2008)
    495. Lack of the leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division. (PubMed id 18288129)1 Poggi A....Zocchi M.R. (Leukemia 2008)
    496. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    497. Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells. (PubMed id 18373696)1 Kim M.J....Lee S.J. (FEBS J. 2008)
    498. The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein-Barr virus. (PubMed id 17967471)1 Kutz H....Kieser A. (Virology 2008)
    499. Fas-mediated autophagy requires JNK activation in HeLa cells. (PubMed id 18996088)1 Zhang Y....Ikejima T. (Biochem. Biophys. Res. Commun. 2008)
    500. Both ERK and JNK are required for enhancement of MD-2 gene expression during differentiation of HL-60 cells. (PubMed id 18181766)1 Li C....Chang Z. (Biol. Cell 2008)
    501. The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells. (PubMed id 17255354)1 Colla S....Shaughnessy J.D. (Blood 2007)
    502. 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. (PubMed id 18003900)1 Hayashi T....Raz E. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    503. Intracellular JNK, p38 MAPK and NF-kappaB regulate IL-25 induced release of cytokines and chemokines from costimulated T helper lymphocytes. (PubMed id 17719653)1 Wong C.K....Lam C.W. (Immunol. Lett. 2007)
    504. Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination. (PubMed id 16983342)1 Trivedi A.K....Behre G. (Oncogene 2007)
    505. Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK. (PubMed id 17363973)1 Wu X. and Sun S.C. (EMBO Rep. 2007)
    506. Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells. (PubMed id 18025271)1 Le X.F....Bast R.C. (Mol. Cancer Ther. 2007)
    507. [Treatment outcome of multidrug resistance related mRNA expression and c-jun-N-terminal kinase activity in patients with acute myeloid leukemia]. (PubMed id 18094581)1 Do J.H....Lee E.Y. (Korean J Lab Med 2007)
    508. Effect of the alpha3beta1 integrin on the IL-1 stimulated activation of c-Jun N-terminal kinase (JNK) in CACO-2 cells. (PubMed id 17481915)1 Stulic M....McGee D.W. (Cytokine 2007)
    509. House dust mite induces expression of intercellular adhesion molecule-1 in EoL-1 human eosinophilic leukemic cells. (PubMed id 17982228)1 Kwon B.C....Shin M.H. (J. Korean Med. Sci. 2007)
    510. Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase. (PubMed id 17702750)1 Bruchas M.R....Chavkin C. (J. Biol. Chem. 2007)
    511. Activin receptor-like kinase 1 inhibits human microvascular endothelial cell migration: potential roles for JNK and ERK. (PubMed id 17620321)1 David L....Bailly S. (J. Cell. Physiol. 2007)
    512. Stabilization of IGFBP-1 mRNA by ethanol in hepatoma cells involves the JNK pathway. (PubMed id 17640761)1 Magne L....Garlatti M. (J. Hepatol. 2007)
    513. Mitogen-activated protein kinases, inhibitory-kappaB kinase, and insulin signaling in human omental versus subcutaneous adipose tissue in obesity. (PubMed id 17317777)1 Bashan N....Rudich A. (Endocrinology 2007)
    514. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1 Wissing J....Daub H. (amp 2007)
    515. Suppression of HIV-1 Tat-induced monocyte adhesiveness by a cell-permeable superoxide dismutase in astrocytes. (PubMed id 18160848)1 Song H.Y....Park J. (amp 2007)
    516. Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes: MAPK inhibitors prevent the increase of IL-1 beta protein levels during beta-endorphin stimulation. (PubMed id 17453826)1 Andjelkov N....Johansen O. (amp 2007)
    517. Involvement of the mitogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. (PubMed id 17785464)1 Kauskot A....Bryckaert M. (J. Biol. Chem. 2007)
    518. The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun. (PubMed id 17704768)1 Koyama-Nasu R....Tanese N. (Nat. Cell Biol. 2007)
    519. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    520. Inhibition of Jun NH2-terminal kinases suppresses the growth of experimental head and neck squamous cell carcinoma. (PubMed id 17908987)1 Gross N.D....Dannenberg A.J. (Clin. Cancer Res. 2007)
    521. Chlamydophilal antigens induce foam cell formation via c-Jun NH2-terminal kinase. (PubMed id 17913539)1 Kitazawa T....Ota Y. (Microbes Infect. 2007)
    522. T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. (PubMed id 17545598)1 Oh S.M....Dong Z. (Cancer Res. 2007)
    523. Involvement of MAPKs and NF-kappaB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells. (PubMed id 17303384)1 Lin W.N....Yang C.M. (Cell. Signal. 2007)
    524. DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress. (PubMed id 17703233)1 Eisenberg-Lerner A. and Kimchi A. (Cell Death Differ. 2007)
    525. Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt. (PubMed id 16412424)1 Biswas K.K....Maruyama I. (FEBS Lett. 2006)
    526. Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase. (PubMed id 16549498)1 Katagiri C....Hibino T. (J. Cell Biol. 2006)
    527. Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. (PubMed id 17178870)1 Shintani Y....Johnson K.R. (Cancer Res. 2006)
    528. Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. (PubMed id 16810318)1 Kitagawa D....Nishina H. (EMBO J. 2006)
    529. Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome drug candidate, blocks neuroinflammatory signalling by targeting the transactivator of transcription (Tat) protein. (PubMed id 16539678)1 Hui B....Geng M. (J. Neurochem. 2006)
    530. Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells. (PubMed id 17145805)1 Zykova T.A....Dong Z. (Clin. Cancer Res. 2006)
    531. Inhibition of JNK promotes differentiation of epidermal keratinocytes. (PubMed id 16648634)1 Gazel A....Blumenberg M. (J. Biol. Chem. 2006)
    532. The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. (PubMed id 16282329)1 Kawamori D....Yamasaki Y. (J. Biol. Chem. 2006)
    533. Tumor necrosis factor-alpha down-regulates human Cu/Zn superoxide dismutase 1 promoter via JNK/AP-1 signaling pathway. (PubMed id 16895791)1 Afonso V....Lomri A. (amp 2006)
    534. HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier. (PubMed id 16395283)1 Hayashi K....Toborek M. (J. Cereb. Blood Flow Metab. 2006)
    535. Neuroprotection by histone deacetylase-related protein. (PubMed id 16611996)1 Morrison B.E.... D'Mello S.R. (Mol. Cell. Biol. 2006)
    536. Helicobacter pylori encoding the pathogenicity island activates matrix metalloproteinase 1 in gastric epithelial cells via JNK and ERK. (PubMed id 16321971)1 Krueger S....Roessner A. (J. Biol. Chem. 2006)
    537. Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1. (PubMed id 16407310)1 Zihni C.... Morris J.D. (J. Biol. Chem. 2006)
    538. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    539. Pro-inflammatory signaling by Jun-N-terminal kinase in inflammatory bowel disease. (PubMed id 16465391)1 Mitsuyama K....Sata M. (Int. J. Mol. Med. 2006)
    540. COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation. (PubMed id 16740711)1 Zhu F....Dong Z. (Cancer Res. 2006)
    541. Effects of SDF-1alpha and gp120IIIB on apoptotic pathways in SK-N-SH neuroblastoma cells. (PubMed id 16481105)1 Geeraerts T....Tardieu M. (Neurosci. Lett. 2006)
    542. Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts. (PubMed id 16699726)1 Du H.J....Huang C.s. (Mol. Cell. Biochem. 2006)
    543. Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. (PubMed id 16446428)1 Gallagher E....Karin M. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    544. Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. (PubMed id 16434970)1 Han Y.H....Zhang X.K. (Oncogene 2006)
    545. Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells. (PubMed id 16927023)1 Ho T.C....Tsao Y.P. (Apoptosis 2006)
    546. Nef induces apoptosis by activating JNK signaling pathway and inhibits NF-kappaB-dependent immune responses in Drosophila. (PubMed id 15827086)1 Lee S.B....Chung J. (J. Cell. Sci. 2005)
    547. BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways. (PubMed id 15516492)1 Jeffery T.K....Morrell N.W. (Am. J. Physiol. Lung Cell Mol. Physiol. 2005)
    548. Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter. (PubMed id 15857981)1 Ylisastigui L....Margolis D. (J. Virol. 2005)
    549. Signaling via the angiotensin-converting enzyme enhances the expression of cyclooxygenase-2 in endothelial cells. (PubMed id 15569856)1 Kohlstedt K....Fleming I. (Hypertension 2005)
    550. The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38). (PubMed id 15733859)1 Kang C.B.... Yoon H.S. (FEBS Lett. 2005)
    551. Direct phosphorylation of proliferative and survival pathway proteins by RET. (PubMed id 16153436)1 Panta G.R....Kim L.T. (Surgery 2005)
    552. MEKK4 is an effector of the embryonic TRAF4 for JNK activation. (PubMed id 16157600)1 Abell A.N. and Johnson G.L. (J. Biol. Chem. 2005)
    553. TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK. (PubMed id 16339571)1 Han B....Liu M. (J. Immunol. 2005)
    554. The phosphorylation of CapZ-interacting protein (CapZIP) by stress- activated protein kinases triggers its dissociation from CapZ. (PubMed id 15850461)1 Eyers C.E.... Cohen P. (Biochem. J. 2005)
    555. The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins. (PubMed id 15722200)1 Schroder W....Sculley T. (Cell. Signal. 2005)
    556. PRAM-1 potentiates arsenic trioxide-induced JNK activation. (PubMed id 15637062)1 Denis F.M.... Lutz P.G. (J. Biol. Chem. 2005)
    557. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. (PubMed id 15696159)1 Yoshida K.... Miki Y. (Nat. Cell Biol. 2005)
    558. Menin represses JunD transcriptional activity in protein kinase C theta-mediated Nur77 expression. (PubMed id 16264271)1 Kim H....Youn H.D. (amp 2005)
    559. Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival. (PubMed id 15688026)1 Patrussi L....Baldari C.T. (Oncogene 2005)
    560. The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity. (PubMed id 16007099)1 Choi B.Y....Dong Z. (amp 2005)
    561. The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed. (PubMed id 15778365)1 Riol-Blanco L....RodrA-guez-FernA!ndez J.L. (J. Immunol. 2005)
    562. Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex. (PubMed id 15749833)1 Funakoshi-Tago M....Kasahara T. (J. Biochem. 2005)
    563. p75NTR--live or let die. (PubMed id 15721744)1 Nykjaer A....Petersen C.M. (Curr. Opin. Neurobiol. 2005)
    564. Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification. (PubMed id 15958389)1 Hofmann T.G....Will H. (J. Biol. Chem. 2005)
    565. Involvement of c-Jun N-terminal kinase in rF1 mediated activation of murine peritoneal macrophages in vitro. (PubMed id 15981086)1 Sharma R.K....Batra H.V. (J. Clin. Immunol. 2005)
    566. (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. (PubMed id 15860507)1 Kim M....Ohigashi H. (Carcinogenesis 2005)
    567. Regulation of apoptotic c-Jun N-terminal kinase signaling by a stabilization-based feed-forward loop. (PubMed id 16260609)1 Xu Z....Greene L.A. (Mol. Cell. Biol. 2005)
    568. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. (PubMed id 15659383)1 Gajate C. and Mollinedo F. (J. Biol. Chem. 2005)
    569. Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. (PubMed id 15590691)1 Singhirunnusorn P....Sakurai H. (J. Biol. Chem. 2005)
    570. Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages. (PubMed id 16243842)1 Varin A....Herbein G. (J. Biol. Chem. 2005)
    571. Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells. (PubMed id 15655348)1 CarA^n R.W....Dent P. (Cell Cycle 2005)
    572. Soluble fractalkine prevents monocyte chemoattractant protein-1-induced monocyte migration via inhibition of stress-activated protein kinase 2/p38 and matrix metalloproteinase activities. (PubMed id 14688370)1 Vitale S....Schmid-Antomarchi H. (J. Immunol. 2004)
    573. JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells. (PubMed id 14701702)1 Davison K....Miller W.H. (Blood 2004)
    574. B cell receptor-mediated apoptosis of human lymphocytes is associated with a new regulatory pathway of Bim isoform expression. (PubMed id 14764673)1 Mouhamad S....Vazquez A. (J. Immunol. 2004)
    575. The effect of C-terminal fragment of JNK2 on the stability of p53 and cell proliferation. (PubMed id 15538975)1 Yin Z.M....Jiang Y. (Cell Res. 2004)
    576. Phosphatidylinositol triphosphate kinase-dependent and c-jun NH2-terminal kinase-dependent induction of telomerase by calcium requires Pyk2. (PubMed id 14729602)1 Alfonso-De Matte M.Y. and Kruk P.A. (Cancer Res. 2004)
    577. Activation of mitogen activated protein kinases via complement receptor type 2. (PubMed id 15603708)1 Luo M.H....Dierich M.P. (Chin. Med. J. 2004)
    578. Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun. (PubMed id 15334056)1 Bitomsky N....Klempnauer K.H. (Oncogene 2004)
    579. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. (PubMed id 14967141)1 Yu C....Lin A. (Mol. Cell 2004)
    580. Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis. (PubMed id 14701799)1 Lewis J....Duckett C.S. (J. Biol. Chem. 2004)
    581. Germinal center kinase is required for optimal Jun N-terminal kinase activation by Toll-like receptor agonists and is regulated by the ubiquitin proteasome system and agonist-induced, TRAF6-dependent stabilization. (PubMed id 15456887)1 Zhong J. and Kyriakis J.M. (Mol. Cell. Biol. 2004)
    582. TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions. (PubMed id 15326485)1 Mori S....Okazaki K. (Oncogene 2004)
    583. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    584. Negative regulation of MEKK1-induced signaling by glutathione S-transferase Mu. (PubMed id 15299005)1 Ryoo K....Choi E.J. (J. Biol. Chem. 2004)
    585. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. (PubMed id 15013949)1 Fujii N....Goodyear L.J. (Am. J. Physiol., Cell Physiol. 2004)
    586. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    587. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    588. Phosphoproteomic analysis of the developing mouse brain. (PubMed id 15345747)1 Ballif B.A....Gygi S.P. (amp 2004)
    589. MD-2: the Toll 'gatekeeper' in endotoxin signalling. (PubMed id 15276183)1 Gangloff M. and Gay N.J. (Trends Biochem. Sci. 2004)
    590. Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. (PubMed id 15483136)1 Lee A.F....Miller F.D. (J. Neurosci. 2004)
    591. CD99 costimulation up-regulates T cell receptor-mediated activation of JNK and AP-1. (PubMed id 15528994)1 Yoon S.S....Kim T.J. (Mol. Cells 2004)
    592. Nuclear factor of activated T cells balances angiogenesis activation and inhibition. (PubMed id 15184502)1 Zaichuk T.A....Volpert O.V. (J. Exp. Med. 2004)
    593. Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression. (PubMed id 15542843)1 Wang W.H....Andrisani O.M. (Mol. Cell. Biol. 2004)
    594. Activation of c-Jun N-terminal kinase mediates gp120IIIB- and nucleoside analogue-induced sensory neuron toxicity. (PubMed id 15246824)1 Bodner A....Miller R.J. (Exp. Neurol. 2004)
    595. SAPKgamma/JNK1 and SAPKalpha/JNK2 mRNA transcripts are expressed in early gestation human placenta and mouse eggs, preimplantation embryos, and trophoblast stem cells. (PubMed id 15474087)1 Zhong W....Rappolee D.A. (Fertil. Steril. 2004)
    596. The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. (PubMed id 15169762)1 Li W. and Guan K.L. (J. Biol. Chem. 2004)
    597. Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. (PubMed id 15383283)1 Wu R.C....O'Malley B.W. (Mol. Cell 2004)
    598. Jun N-terminal kinase activity and early growth-response factor-1 gene expression are down-regulated in Fanconi anemia group A lymphoblasts. (PubMed id 12958075)1 Pipaon C....Fernandez-Luna J.L. (Blood 2004)
    599. The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria. (PubMed id 15225643)1 Tamura Y....Osada H. (FEBS Lett. 2004)
    600. Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein. (PubMed id 12874243)1 Jensen L.E. and Whitehead A.S. (J. Immunol. 2003)
    601. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. (PubMed id 12591950)1 Lei K. and Davis R.J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    602. The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling. (PubMed id 14557276)1 Han J....Tan T.H. (J. Biol. Chem. 2003)
    603. T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1). (PubMed id 14572659)1 Dadgostar H....Cheng G. (FEBS Lett. 2003)
    604. JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. (PubMed id 12818176)1 Putcha G.V....Johnson E.M. (Neuron 2003)
    605. Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. (PubMed id 12878610)1 Luo W....Lin S.C. (J. Biol. Chem. 2003)
    606. Fibronectin blocks p38 and jnk activation by cyclic strain in Caco-2 cells. (PubMed id 12810082)1 Zhang J....Basson M.D. (Biochem. Biophys. Res. Commun. 2003)
    607. JNK phosphorylates paxillin and regulates cell migration. (PubMed id 12853963)1 Huang C....Jacobson K. (Nature 2003)
    608. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. (PubMed id 14633987)1 Ishitani T....Matsumoto K. (EMBO J. 2003)
    609. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. (PubMed id 12734330)1 Takeda A....Yoshida H. (J. Immunol. 2003)
    610. Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis. (PubMed id 12576423)1 Dolled-Filhart M....Rimm D.L. (Clin. Cancer Res. 2003)
    611. HIV-1 Nef triggers Vav-mediated signaling pathway leading to functional and morphological differentiation of dendritic cells. (PubMed id 14597672)1 Quaranta M.G....Viora M. (FASEB J. 2003)
    612. A JNK-dependent pathway is required for TNFalpha-induced apoptosis. (PubMed id 14532003)1 Deng Y....Wu X. (Cell 2003)
    613. Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR). (PubMed id 12787561)1 Rabizadeh S. and Bredesen D.E. (amp 2003)
    614. Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism. (PubMed id 14551213)1 Lo R.K....Wong Y.H. (J. Biol. Chem. 2003)
    615. p57KIP2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein Kinase. (PubMed id 12963725)1 Chang T.S....Choi E.J. (J. Biol. Chem. 2003)
    616. The lectin jacalin induces phosphorylation of ERK and JNK in CD4+ T cells. (PubMed id 12714584)1 Tamma S.M....Modesto R.R. (J. Leukoc. Biol. 2003)
    617. Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi. (PubMed id 12646564)1 Elsby R....Park B.K. (J. Biol. Chem. 2003)
    618. HIV-1 gp120 chemokine receptor-mediated signaling in human macrophages. (PubMed id 12857973)1 Freedman B.D....Collman R.G. (Immunol. Res. 2003)
    619. Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. (PubMed id 12960231)1 Lee C....Collman R.G. (J. Leukoc. Biol. 2003)
    620. Inducible expression of RbAp46 activates c-Jun NH2-terminal kinase-dependent apoptosis and suppresses progressive growth of tumor xenografts in nude mice. (PubMed id 14981905)1 Zhang T.F....Wang Z.Y. (Anticancer Res. 2003)
    621. Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells. (PubMed id 14612408)1 Kolluri S.K....Zhang X.K. (Mol. Cell. Biol. 2003)
    622. Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells. (PubMed id 12478662)1 Kang H.J....Moon A. (Int. J. Cancer 2003)
    623. Pellino2 activates the mitogen activated protein kinase pathway. (PubMed id 12804775)1 Jensen L.E. and Whitehead A.S. (FEBS Lett. 2003)
    624. Inflammatory cytokine expression is independent of the c-Jun N-terminal kinase/AP-1 signaling cascade in human neutrophils. (PubMed id 14500675)1 Cloutier A....McDonald P.P. (J. Immunol. 2003)
    625. Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. (PubMed id 12763138)1 Wierenga A.T.... Vellenga E. (Exp. Hematol. 2003)
    626. Daxx silencing sensitizes cells to multiple apoptotic pathways. (PubMed id 14517282)1 Chen L.Y. and Chen J.D. (Mol. Cell. Biol. 2003)
    627. Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. (PubMed id 12775419)1 Galey D....Nath A. (J. Neurovirol. 2003)
    628. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. (PubMed id 12689591)1 Chang L....Karin M. (Dev. Cell 2003)
    629. Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation. (PubMed id 14637155)1 Kim Y.Y....Park S.I. (Biochem. Biophys. Res. Commun. 2003)
    630. Extracellular regulated kinase and c-Jun N-terminal kinase are activated in psoriatic involved epidermis. (PubMed id 12413764)1 Takahashi H....Iizuka H. (J. Dermatol. Sci. 2002)
    631. Induced proliferation of human MRC-5 cells by nitrogen oxides via direct and indirect activation of MEKK1, JNK, and p38 signals. (PubMed id 12079429)1 Chou F.P....Wang C.J. (Toxicol. Appl. Pharmacol. 2002)
    632. Unimpaired activation of c-Jun NH2-terminal kinase (JNK) 1 upon CD40 stimulation in B cells of patients with X-linked agammaglobulinemia. (PubMed id 12148599)1 Brunner C....Schuster V. (J. Clin. Immunol. 2002)
    633. A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria. (PubMed id 12167088)1 Wiltshire C.... May G.H. (Biochem. J. 2002)
    634. HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication. (PubMed id 12089333)1 Cicala C....Fauci A.S. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    635. Relationship of Mcl-1 isoforms, ratio p21WAF1/cyclin A, and Jun kinase phosphorylation to apoptosis in human breast carcinomas. (PubMed id 12359245)1 Rieber M....Strasberg-Rieber M. (Biochem. Biophys. Res. Commun. 2002)
    636. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. (PubMed id 12351658)1 Gao Z....Ye J. (J. Biol. Chem. 2002)
    637. Regulation of two JunD isoforms by Jun N-terminal kinases. (PubMed id 12052834)1 Yazgan O. and Pfarr C.M. (J. Biol. Chem. 2002)
    638. Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus. (PubMed id 11948398)1 Hurd C....Rozengurt E. (Oncogene 2002)
    639. Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase. (PubMed id 11988087)1 Dickinson R.J....Keyse S.M. (Biochem. J. 2002)
    640. Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins. (PubMed id 11912216)1 Parnell S.C....Calvet J.P. (J. Biol. Chem. 2002)
    641. Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation. (PubMed id 11700324)1 Cai Y....Dressler G.R. (J. Biol. Chem. 2002)
    642. Activation of extracellular signal-regulated kinase through B-cell antigen receptor in B-cell chronic lymphocytic leukemia. (PubMed id 12095152)1 Kawauchi K....Yasuyama M. (Int. J. Hematol. 2002)
    643. Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases. (PubMed id 12097334)1 Troy C.M....Friedman W.J. (J. Biol. Chem. 2002)
    644. Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation. (PubMed id 12228228)1 Gallagher E.D....Cobb M.H. (J. Biol. Chem. 2002)
    645. Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes. (PubMed id 12039864)1 Huang S.T. and Cidlowski J.A. (FASEB J. 2002)
    646. Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. (PubMed id 12171600)1 Knebel A....Cohen P. (Biochem. J. 2002)
    647. The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation. (PubMed id 12058028)1 Kim G.Y....Friedman E. (J. Biol. Chem. 2002)
    648. Role of Cbl in shear-activation of PI 3-kinase and JNK in endothelial cells. (PubMed id 11944898)1 Miao H....Chien S. (Biochem. Biophys. Res. Commun. 2002)
    649. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    650. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. (PubMed id 11931768)1 Zhang J.... Roeder R.G. (Mol. Cell 2002)
    651. Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. (PubMed id 11971973)1 Gabai V.L....Sherman M.Y. (Mol. Cell. Biol. 2002)
    652. Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2. (PubMed id 12225289)1 Katz S. and Aronheim A. (Biochem. J. 2002)
    653. JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. (PubMed id 12391307)1 Lee C.M.... Reddy E.P. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    654. Galpha13 induces preproET-1 gene expression via JNK. (PubMed id 12135322)1 Yamakaw K....Tomita K. (Hypertens. Res. 2002)
    655. Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation. (PubMed id 11788583)1 Ku N.O.... Omary M.B. (J. Biol. Chem. 2002)
    656. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. (PubMed id 11606564)1 Aguirre V....White M.F. (J. Biol. Chem. 2002)
    657. gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes. (PubMed id 12239168)1 Kinet S....Taylor N. (Blood 2002)
    658. The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase. (PubMed id 11781324)1 He T.... Eriksson J.E. (J. Biol. Chem. 2002)
    659. Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation. (PubMed id 11983683)1 She Q.B....Dong Z. (J. Biol. Chem. 2002)
    660. Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2. (PubMed id 11551945)1 Janknecht R. (J. Biol. Chem. 2001)
    661. Extracellular Tat activates c-fos promoter in low serum-starved CD4+ T cells. (PubMed id 11260070)1 Gibellini D....Zauli G. (Br. J. Haematol. 2001)
    662. The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase. (PubMed id 11602244)1 Katz S....Aronheim A. (FEBS Lett. 2001)
    663. A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation. (PubMed id 11432831)1 Girardin S.E. and Yaniv M. (EMBO J. 2001)
    664. Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. (PubMed id 11278799)1 Slack D.N.... Keyse S.M. (J. Biol. Chem. 2001)
    665. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. (PubMed id 11238452)1 Verhey K.J.... Margolis B. (J. Cell Biol. 2001)
    666. Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3. (PubMed id 11350938)1 Deb A....Williams B.R. (EMBO J. 2001)
    667. MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein. (PubMed id 11489891)1 Masuda K.... Kikuchi K. (J. Biol. Chem. 2001)
    668. HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway. (PubMed id 11468147)1 MissAc D....Veas F. (Blood 2001)
    669. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. (PubMed id 11279118)1 Chen Z. and Cobb M.H. (J. Biol. Chem. 2001)
    670. Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. (PubMed id 11279197)1 Wang T....Tew K.D. (J. Biol. Chem. 2001)
    671. Differences in patterns of activation of MAP kinases induced by oncogenic ras-p21 and insulin in oocytes. (PubMed id 11525649)1 Ranginwale M....Pincus M.R. (Exp. Cell Res. 2001)
    672. HIV envelope gp120 activates human arterial smooth muscle cells. (PubMed id 11504923)1 Schecter A.D....Taubman M.B. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    673. Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen-activated protein kinase ERK2. (PubMed id 11408587)1 Jesch S.A.... Linstedt A.D. (Mol. Biol. Cell 2001)
    674. Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically. (PubMed id 11387337)1 Chen P....Liu Y. (J. Biol. Chem. 2001)
    675. Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. (PubMed id 11479302)1 Tada K....Nakano H. (J. Biol. Chem. 2001)
    676. MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28. (PubMed id 11278789)1 Zhong S....Dong Z. (J. Biol. Chem. 2001)
    677. HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling. (PubMed id 11698270)1 Del Corno M....Collman R.G. (Blood 2001)
    678. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. (PubMed id 10629060)1 Kelkar N....Davis R.J. (Mol. Cell. Biol. 2000)
    679. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    680. The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades. (PubMed id 11042694)1 Ducret C....Wasylyk B. (Oncogene 2000)
    681. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. (PubMed id 10797012)1 Tournier C....Davis R.J. (Science 2000)
    682. Downregulation of p53 by sustained JNK activation during apoptosis. (PubMed id 11108663)1 Wang J. and Friedman E. (Mol. Carcinog. 2000)
    683. The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk. (PubMed id 10962563)1 Garcia-Guzman M....Vuori K. (Oncogene 2000)
    684. Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells. (PubMed id 10912793)1 Spector M....Gao B. (Exp. Cell Res. 2000)
    685. Signal transduction by the JNK group of MAP kinases. (PubMed id 11057897)1 Davis R.J. (Cell 2000)
    686. cDNA cloning and mapping of a novel islet-brain/JNK interacting protein. (PubMed id 10756100)1 Negri S.... Bonny C. (Genomics 2000)
    687. p38 MAPK signalling cascades: ancient roles and new functions. (PubMed id 10878576)1 MartA-n-Blanco E. (Bioessays 2000)
    688. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). (PubMed id 10722755)1 Aguirre V....White M.F. (J. Biol. Chem. 2000)
    689. Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm. (PubMed id 10419510)1 ZA_A+iga A....Pulido R. (J. Biol. Chem. 1999)
    690. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. (PubMed id 10391943)1 Tanoue T.... Nishida E. (J. Biol. Chem. 1999)
    691. Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases. (PubMed id 10383391)1 Adam-Stitah S....Rochette-Egly C. (J. Biol. Chem. 1999)
    692. Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase. (PubMed id 10551811)1 Noguchi K....Kuchino Y. (J. Biol. Chem. 1999)
    693. Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner. (PubMed id 10446219)1 Jain N....Cao X. (J. Biol. Chem. 1999)
    694. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway. (PubMed id 10187783)1 Lu Y.... Stewart T.A. (J. Biol. Chem. 1999)
    695. A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. (PubMed id 10393177)1 Kawasaki M....Matsumoto K. (EMBO J. 1999)
    696. Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. (PubMed id 10394361)1 Fackler O.T....Peterlin B.M. (Mol. Cell 1999)
    697. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. (PubMed id 10357815)1 Park J....Hemmings B.A. (EMBO J. 1999)
    698. Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. (PubMed id 10601313)1 Engel M.E....Moses H.L. (J. Biol. Chem. 1999)
    699. Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation. (PubMed id 9889198)1 Li B....Flavell R.A. (EMBO J. 1999)
    700. JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. (PubMed id 10523642)1 Ito M....Yamamoto K.I. (Mol. Cell. Biol. 1999)
    701. MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. (PubMed id 10597297)1 Theodosiou A.... Ashworth A. (Oncogene 1999)
    702. MyD88, an adapter protein involved in interleukin-1 signaling. (PubMed id 9575168)1 Burns K....Tschopp J. (J. Biol. Chem. 1998)
    703. Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. (PubMed id 9788880)1 Dowd S....Keyse S.M. (J. Cell. Sci. 1998)
    704. Defective T cell differentiation in the absence of Jnk1. (PubMed id 9851932)1 Dong C....Flavell R.A. (Science 1998)
    705. Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells. (PubMed id 9621077)1 Ganju R.K....Groopman J.E. (J. Virol. 1998)
    706. JNK targets p53 ubiquitination and degradation in nonstressed cells. (PubMed id 9732264)1 Fuchs S.Y....Ronai Z. (amp 1998)
    707. Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK). (PubMed id 9872331)1 Jain N....Cao X. (Oncogene 1998)
    708. The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2. (PubMed id 9692890)1 Gravestein L.A....Borst J. (Eur. J. Immunol. 1998)
    709. The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death. (PubMed id 9520479)1 Bazenet C.E....Rubin L.L. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    710. MEKK1/JNK signaling stabilizes and activates p53. (PubMed id 9724739)1 Fuchs S.Y....Ronai Z. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    711. Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor. (PubMed id 9199329)1 Krstic M.D....Garabedian M.J. (Mol. Cell. Biol. 1997)
    712. Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. (PubMed id 9030579)1 Adams M....Chatterjee V.K. (J. Biol. Chem. 1997)
    713. An RGD containing peptide from HIV-1 Tat-(65-80) modulates protooncogene expression in human bronchoalveolar carcinoma cell line, A549. (PubMed id 9129988)1 el-Solh A....Lwebuga-Mukasa J.S. (Immunol. Invest. 1997)
    714. MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. (PubMed id 9405400)1 Xu S. and Cobb M.H. (J. Biol. Chem. 1997)
    715. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. (PubMed id 9343414)1 Chung J....Blenis J. (Mol. Cell. Biol. 1997)
    716. JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases. (PubMed id 9393873)1 Hu M.C....Wang Y.P. (Oncogene 1997)
    717. Tat protein induces self-perpetuating permissivity for productive HIV-1 infection. (PubMed id 9223324)1 Li C.J....Pardee A.B. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    718. Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav- mediated c-Jun N-terminal kinase activation. (PubMed id 9399639)1 Bustelo X.R.... Barbacid M. (Oncogene 1997)
    719. A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion. (PubMed id 9195981)1 Mizukami Y....Yoshida K.i. (J. Biol. Chem. 1997)
    720. p38-2, a novel mitogen-activated protein kinase with distinct properties. (PubMed id 9235954)1 Stein B....Barbosa M.S. (J. Biol. Chem. 1997)
    721. Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. (PubMed id 9374537)1 Li S....Shyy J.Y. (J. Biol. Chem. 1997)
    722. Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells. (PubMed id 9211903)1 Liao J....Omary M.B. (J. Biol. Chem. 1997)
    723. Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. (PubMed id 8917518)1 Mendelson K.G....Paulson K.E. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    724. Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase. (PubMed id 7642542)1 Kharbanda S....Kyriakis J. (J. Biol. Chem. 1995)
    725. Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. (PubMed id 8846788)1 Cavigelli M....Karin M. (EMBO J. 1995)
    726. Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction. (PubMed id 8586671)1 Cano E....Mahadevan L.C. (J. Cell. Sci. 1995)
    727. ATF-2 contains a phosphorylation-dependent transcriptional activation domain. (PubMed id 7737129)1 Livingstone C....Jones N. (EMBO J. 1995)
    728. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. (PubMed id 7737130)1 van Dam H....Angel P. (EMBO J. 1995)
    729. The stress-activated protein kinase subfamily of c-Jun kinases. (PubMed id 8177321)1 Kyriakis J.M....Woodgett J.R. (Nature 1994)
    730. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. (PubMed id 8224842)1 Hibi M....Karin M. (amp 1993)
    731. A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression. (PubMed id 1748630)1 Seth A....Davis R.J. (J. Biol. Chem. 1991)
    732. The role of stress-activated protein kinase signaling in renal pathophysiology. (PubMed id 18982195)9 Ma F.Y....Nikolic-Paterson D.J. (Braz. J. Med. Biol. Res. 2009)
    733. Selective expression of JNK isoforms and stress-specific JNK activity in different neural cell lines. (PubMed id 10648896)9 Mielke K....Herdegen T. (Brain Res. Mol. Brain Res. 2000)
    734. Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases. (PubMed id 9430657)9 Tanaka S. and Hanafusa H. (J. Biol. Chem. 1998)
    735. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. (PubMed id 8557665)9 Chen Y.R....Tan T.H. (J. Biol. Chem. 1996)
    736. Role of JNK activation in pancreatic beta-cell death by streptozotocin. (PubMed id 20176078)9 Cheon H....Lee M.S. (Mol. Cell. Endocrinol. 2010)
    737. Sustained activation of c-jun-N-terminal kinase plays a critical role in arsenic trioxide-induced cell apoptosis in multiple myeloma cell lines. (PubMed id 16734734)9 Kajiguchi T....Naoe T. (Cancer Sci. 2006)
    738. Nitric oxide-mediated activation of extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK) during hypoxia in cerebral cortical nuclei of newborn piglets. (PubMed id 14667452)9 Mishra O.P....Ashraf Q.M. (Neuroscience 2004)
    739. Activation of JNK by TPA promotes apoptosis via PKC pathway in gastric cancer cells. (PubMed id 12439916)9 Chen Y....Su W.J. (World J. Gastroenterol. 2002)
    740. Conservation of the positions of metazoan introns from sponges to humans. (PubMed id 12354665)9 MA1ller W.E....Gamulin V. (Gene 2002)
    741. Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity. (PubMed id 10910949)9 Chuang S.M....Yang J.L. (Carcinogenesis 2000)
    742. All-trans-retinoic acid inhibits Jun N-terminal kinase by increasing dual-specificity phosphatase activity. (PubMed id 10022884)9 Lee H.Y....Kurie J.M. (Mol. Cell. Biol. 1999)
    743. Arachidonic acid activates Jun N-terminal kinase in vascular smooth muscle cells. (PubMed id 9467967)9 Madamanchi N.R....Rao G.N. (Oncogene 1998)
    744. Analysis of the interaction between c-Jun and c-Jun N-terminal kinase in vivo. (PubMed id 9837920)9 May G.H....Gillespie D.A. (J. Biol. Chem. 1998)
    745. Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals. (PubMed id 9514699)9 Liu B....Whisler R.L. (Cell. Immunol. 1997)
    746. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors. (PubMed id 9111305)9 Whitmarsh A.J....Davis R.J. (Mol. Cell. Biol. 1997)
    747. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. (PubMed id 8943238)9 Chen Y.R....Tan T.H. (J. Biol. Chem. 1996)
    748. Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure. (PubMed id 17185352)9 Henderson N.C....Simpson K.J. (Gut 2007)
    749. Role of the phosphatase PP4 in the activation of JNK-1 in prostate carcinoma cell lines PC-3 and LNCaP resulting in increased AP-1 and EGR-1 activity. (PubMed id 16238095)9 Inostroza J....Parra E. (Biol. Res. 2005)
    750. Reverse two-hybrid screening identifies residues of JNK required for interaction with the kinase interaction motif of JNK-interacting protein-1. (PubMed id 15271995)9 Barr R.K....Bogoyevitch M.A. (J. Biol. Chem. 2004)
    751. Short-term depletion of catalase suppresses cadmium-elicited c-Jun N-terminal kinase activation and apoptosis: role of protein phosphatases. (PubMed id 12538343)9 Chuang S.M....Yang J.L. (Carcinogenesis 2003)
    752. Activation and role of MAP kinase-dependent pathways in retinal pigment epithelium cells: JNK1, P38 kinase, and cell death. (PubMed id 12601065)9 Hecquet C....Mascarelli F. (amp 2003)
    753. Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. (PubMed id 12161751)9 Hess P....Davis R.J. (Nat. Genet. 2002)
    754. Insulin-like growth factor-I and Bcl-X(L) inhibit c-jun N-terminal kinase activation and rescue Schwann cells from apoptosis. (PubMed id 11158266)9 Cheng H.L....Feldman E.L. (J. Neurochem. 2001)
    755. The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells. (PubMed id 10022881)9 Bost F....Mercola D. (Mol. Cell. Biol. 1999)
    756. Thyrotropin regulates c-Jun N-terminal kinase (JNK) activity through two distinct signal pathways in human thyroid cells. (PubMed id 10098509)9 Hara T....Yamashita S. (Endocrinology 1999)
    757. c-Jun N-terminal kinase mediates apoptotic signaling induced by N-(4-hydroxyphenyl)retinamide. (PubMed id 10570055)9 Chen Y.R....Tan T.H. (Mol. Pharmacol. 1999)
    758. Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells. (PubMed id 19549704)9 Sahu R.P....Srivastava S.K. (Carcinogenesis 2009)
    759. Requirements for PKC-augmented JNK activation by MKK4/7. (PubMed id 18182317)9 Lopez-Bergami P. and Ronai Z. (amp 2008)
    760. JNK as a positive regulator of angiogenic potential in endothelial cells. (PubMed id 18455449)9 Uchida C....Haas T.L. (Cell Biol. Int. 2008)
    761. Stimulation-specific contribution of p38 and JNK to IFN-beta gene expression in human macrophages. (PubMed id 17892396)9 Reimer T....Jungi T.W. (amp 2007)
    762. JNK signalling: a possible target to prevent neurodegeneration. (PubMed id 17584114)9 Borsello T. and Forloni G. (Curr. Pharm. Des. 2007)
    763. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. (PubMed id 16571763)9 Zhuang Z.Y....Ji R.R. (J. Neurosci. 2006)
    764. [ERK and JNK/AP-1 pathways involved in benzo(a)pyrene induced cell cycle changes in human embryo lung fibroblasts]. (PubMed id 16600107)9 Gao A....Ye M. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2006)
    765. C-Jun N-terminal kinase (JNK) regulation of iNOS expression in glial cells: predominant role of JNK1 isoform. (PubMed id 16771680)9 Pawate S. and Bhat N.R. (amp 2006)
    766. Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons. (PubMed id 15932641)9 Etter P.D....Ramaswami M. (BMC Neurosci 2005)
    767. Ceramide promotes apoptosis in lung cancer-derived A549 cells by a mechanism involving c-Jun NH2-terminal kinase. (PubMed id 15520191)9 Kurinna S.M....Ruvolo P.P. (Cancer Res. 2004)
    768. The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK. (PubMed id 15208323)9 Barr R.K....Bogoyevitch M.A. (J. Biol. Chem. 2004)
    769. Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway. (PubMed id 15389886)9 Zhang X....Yu Q. (J. Cell. Biochem. 2004)
    770. Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death. (PubMed id 15192112)9 Cao J....Courtney M.J. (J. Biol. Chem. 2004)
    771. A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons. (PubMed id 12534344)9 Fogarty M.P....Campbell V. (Biochem. J. 2003)
    772. The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK. (PubMed id 12524447)9 Willoughby E.A....Whitmarsh A.J. (J. Biol. Chem. 2003)
    773. Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3. (PubMed id 12805110)9 Middlemas A....Fernyhough P. (Brain 2003)
    774. Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids. (PubMed id 14609950)9 Bruna A....Caelles C. (EMBO J. 2003)
    775. Cell line dependent involvement of ceramide in ultraviolet light-induced apoptosis. (PubMed id 11354249)9 Chatterjee M. and Wu S. (Mol. Cell. Biochem. 2001)
    776. Apoptosis and JNK activation are differentially regulated by Fas expression level in renal tubular epithelial cells. (PubMed id 11422737)9 Khan S....Schelling J.R. (Kidney Int. 2001)
    777. Differential regulation of JNK activation and MKP-1 expression by peroxovanadium complexes. (PubMed id 11137629)9 Rumora L....Maysinger D. (Neurochem. Int. 2001)
    778. Suppression of stress kinase JNK is involved in HSP72-mediated protection of myogenic cells from transient energy deprivation. HSP72 alleviates the stewss-induced inhibition of JNK dephosphorylation. (PubMed id 10978340)9 Gabai V.L....Sherman M.Y. (J. Biol. Chem. 2000)
    779. Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. (PubMed id 10874022)9 Chuang S.M....Yang J.L. (Carcinogenesis 2000)
    780. Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors. (PubMed id 10051431)9 Wylie P.G....Blank J.L. (Biochem. J. 1999)
    781. Signal transduction pathways regulated by arsenate and arsenite. (PubMed id 10618720)9 Porter A.C....Vaillancourt R.R. (Oncogene 1999)
    782. Thrombin activates two stress-activated protein kinases, c-Jun N-terminal kinase and p38, in HepG2 cells. (PubMed id 9581692)9 Mitsui H....Takuwa Y. (Hepatology 1998)
    783. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. (PubMed id 9430725)9 Chen Y.R....Tan T.H. (J. Biol. Chem. 1998)
    784. Neurotrophic factors prevent ceramide-induced apoptosis downstream of c-Jun N-terminal kinase activation in PC12 cells. (PubMed id 9648862)9 Hartfield P.J....Murray A.W. (J. Neurochem. 1998)
    785. Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction. (PubMed id 9278437)9 Wang W....Tan T.H. (J. Biol. Chem. 1997)
    786. NF-kappaB mediates MPP+-induced apoptotic cell death in neuroblastoma cells SH-EP1 through JNK and c-Jun/AP-1. (PubMed id 19778565)9 Yang H.J....Feng Z.W. (Neurochem. Int. 2010)
    787. Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet graft function. (PubMed id 18925829)9 Noguchi H....Levy M.F. (Hum. Gene Ther. 2009)
    788. Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells. (PubMed id 17698970)9 Lu G.D....Ong C.N. (Carcinogenesis 2007)
    789. Sustained JNK activation in response to tumor necrosis factor is mediated by caspases in a cell type-specific manner. (PubMed id 17121845)9 Wicovsky A....Wajant H. (J. Biol. Chem. 2007)
    790. c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells. (PubMed id 17057737)9 Khatlani T.S....Kurie J.M. (Oncogene 2007)
    791. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. (PubMed id 17591974)9 Tong C....Yang W. (Am. J. Pathol. 2007)
    792. JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. (PubMed id 16618812)9 Tararuk T....Coffey E.T. (J. Cell Biol. 2006)
    793. Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. (PubMed id 17060633)9 Liao G....Kuan C.Y. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    794. JNK and ROKalpha function in the noncanonical Wnt/RhoA signaling pathway to regulate Xenopus convergent extension movements. (PubMed id 15739222)9 Kim G.H. and Han J.K. (Dev. Dyn. 2005)
    795. c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia. (PubMed id 15604272)9 Comerford K.M....Taylor C.T. (Cancer Res. 2004)
    796. Cooperation between PKC-alpha and PKC-epsilon in the regulation of JNK activation in human lung cancer cells. (PubMed id 14709334)9 Lang W....Xiao L. (Cell. Signal. 2004)
    797. Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells. (PubMed id 15247770)9 Mizuno R....Murai M. (J. Urol. 2004)
    798. Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. (PubMed id 12629045)9 Kennedy N.J....Davis R.J. (amp 2003)
    799. Role of JNK in tumor development. (PubMed id 12734425)9 Kennedy N.J. and Davis R.J. (Cell Cycle 2003)
    800. C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP. (PubMed id 11850819)9 Engedal N....Saatcioglu F. (Oncogene 2002)
    801. Dual-specificity protein tyrosine phosphatase VHR down-regulates c-Jun N-terminal kinase (JNK). (PubMed id 11971192)9 Todd J.L....Denu J.M. (Oncogene 2002)
    802. Ultraviolet radiation-induced apoptosis is mediated by Daxx. (PubMed id 12407442)9 Wu S....Rehemtulla A. (Neoplasia 2002)
    803. Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells. (PubMed id 11678615)9 Chuang S.M. and Yang J.L. (Mol. Cell. Biochem. 2001)
    804. Downregulation of Jun kinase signaling in the amnioserosa is essential for dorsal closure of the Drosophila embryo. (PubMed id 11509232)9 Reed B.H....Lipshitz H.D. (Curr. Biol. 2001)
    805. NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B. (PubMed id 11466617)9 Javelaud D. and BesanAson F. (Oncogene 2001)
    806. Inactivation of JNK activity by mitogen-activated protein kinase phosphatase-2 in EAhy926 endothelial cells is dependent upon agonist-specific JNK translocation to the nucleus. (PubMed id 11257445)9 Robinson C.J....Plevin R. (Cell. Signal. 2001)
    807. Prolactin stimulates activation of c-jun N-terminal kinase (JNK). (PubMed id 11043575)9 Schwertfeger K.L....Anderson S.M. (Mol. Endocrinol. 2000)
    808. JNK and p38 are activated by erythropoietin (EPO) but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells. (PubMed id 10910907)9 Jacobs-Helber S.M....Sawyer S.T. (Blood 2000)
    809. Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons. (PubMed id 11027220)9 Coffey E.T....Courtney M.J. (J. Neurosci. 2000)
    810. Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C-terminus via a mechanism involving TRADD and TRAF2. (PubMed id 9882303)9 Eliopoulos A.G.... Young L.S. (J. Virol. 1999)
    811. Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. (PubMed id 10082520)9 Meriin A.B....Sherman M.Y. (Mol. Cell. Biol. 1999)
    812. The function of HSP72 in suppression of c-Jun N-terminal kinase activation can be dissociated from its role in prevention of protein damage. (PubMed id 10400639)9 Yaglom J.A....Sherman M.Y. (J. Biol. Chem. 1999)
    813. Atrial natriuretic peptide inhibits endothelin-1-induced activation of JNK in glomerular mesangial cells. (PubMed id 9573527)9 Isono M....Kikkawa R. (Kidney Int. 1998)
    814. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. (PubMed id 9674701)9 Chen Y.R. and Tan T.H. (Oncogene 1998)
    815. Differential regulation of extracellular signal-regulated protein kinase 1 and Jun N-terminal kinase 1 by Ca2+ and protein kinase C in endothelin-stimulated Rat-1 cells. (PubMed id 9032468)9 Cadwallader K....Cook S. (Biochem. J. 1997)
    816. Decreased ERK and JNK signaling contribute to gene overexpression in &quot;senescent&quot; CD4+CD28- T cells through epigenetic mechanisms. (PubMed id 19843577)9 Chen Y....Richardson B.C. (J. Leukoc. Biol. 2010)
    817. Jnk signaling pathway-mediated regulation of Stat3 activation is linked to the development of doxorubicin resistance in cancer cell lines. (PubMed id 19766599)9 Kim J.H....Yoon S. (Biochem. Pharmacol. 2010)
    818. Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation. (PubMed id 19654923)9 Chen L....Xia Y. (Environ. Health Perspect. 2009)
    819. c-Jun N-terminal kinase mediates disassembly of apical junctions in model intestinal epithelia. (PubMed id 19502798)9 Naydenov N.G....Ivanov A.I. (Cell Cycle 2009)
    820. Role of p38 and JNK in liver ischemia and reperfusion. (PubMed id 19680593)9 King L.A....Toledo-Pereyra L.H. (J Hepatobiliary Pancreat Surg 2009)
    821. The contribution of c-Jun N-terminal kinase activation and subsequent Bcl-2 phosphorylation to apoptosis induction in human B-cells is dependent on the mode of action of specific stresses. (PubMed id 18201741)9 Muscarella D.E. and Bloom S.E. (Toxicol. Appl. Pharmacol. 2008)
    822. Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function. (PubMed id 18434301)9 Uddin M.N....Puschett J.B. (J. Biol. Chem. 2008)
    823. Inhibition of c-Jun N-terminal kinase sensitizes tumor cells to flavonoid-induced apoptosis through down-regulation of JunD. (PubMed id 18078968)9 Kook S.H....Lee J.C. (Toxicol. Appl. Pharmacol. 2008)
    824. Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy. (PubMed id 17891170)9 Nieto-Miguel T....Mollinedo F. (Oncogene 2008)
    825. NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma. (PubMed id 17416736)9 Leventaki V....Rassidakis G.Z. (Blood 2007)
    826. Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway. (PubMed id 17525747)9 Oleinik N.V.... Krupenko S.A. (Oncogene 2007)
    827. Regulation of p21Waf1 expression and TNFalpha biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: involvement of JNK and ERK pathways. (PubMed id 17920036)9 Debbas V....Monteiro H.P. (Biochem. Biophys. Res. Commun. 2007)
    828. Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells. (PubMed id 16739127)9 Yuan X....Kong A.N. (Mol. Carcinog. 2006)
    829. Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients. (PubMed id 16890760)9 Loke T.K....Corrigan C.J. (J. Allergy Clin. Immunol. 2006)
    830. c-Jun N-terminal kinase negatively regulates dsRNA and RSV induction of tumor necrosis factor- alpha transcription in human epithelial cells. (PubMed id 16881863)9 Stewart M.J....Imani F. (amp 2006)
    831. Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy. (PubMed id 15723614)9 Kuan C.Y. and Burke R.E. (Curr Drug Targets CNS Neurol Disord 2005)
    832. JIP1 regulates neuronal apoptosis in response to stress. (PubMed id 15836924)9 Dong Z....Miller C.A. (Brain Res. Mol. Brain Res. 2005)
    833. [Expression and clinical significance of MAPK in non-small cell lung cancer]. (PubMed id 15854513)9 Zhang Z.F....Zhang L. (Zhonghua Yi Xue Za Zhi 2005)
    834. Human cells deficient in transcription-coupled repair show prolonged activation of the Jun N-terminal kinase and increased sensitivity following cisplatin treatment. (PubMed id 15841377)9 Bulmer J.T....Rainbow A.J. (Cancer Chemother. Pharmacol. 2005)
    835. Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB. (PubMed id 14713952)9 Habelhah H....Ronai Z. (EMBO J. 2004)
    836. Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets. (PubMed id 15242986)9 Aikin R....Rosenberg L. (Endocrinology 2004)
    837. [Induction of monocyte chemoattractant protein-1 expression in human mesangial cells by angiotensin II: role of c-Jun N-terminal kinase-c-Jun/activator protein-1 signal pathway]. (PubMed id 15634454)9 Zhang A.H....Chen R.H. (Zhonghua Bing Li Xue Za Zhi 2004)
    838. JNK: a key modulator of intracellular signaling. (PubMed id 15377263)9 Vlahopoulos S. and Zoumpourlis V.C. (Biochemistry Mosc. 2004)
    839. Extracellular signal-regulated kinase, Jun N-terminal kinase, p38, and c-Src are involved in gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone follicle-stimulating hormone beta-subunit promoter. (PubMed id 14736735)9 Bonfil D....Naor Z. (Endocrinology 2004)
    840. JNK is associated with Bcl-2 and PP1 in mitochondria: paclitaxel induces its activation and its association with the phosphorylated form of Bcl-2. (PubMed id 15467450)9 Brichese L....Valette A. (Cell Cycle 2004)
    841. Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells. (PubMed id 15256485)9 Zhang S....Shen H.M. (Carcinogenesis 2004)
    842. All-trans retinoic acid potentiates Taxotere-induced cell death mediated by Jun N-terminal kinase in breast cancer cells. (PubMed id 14724571)9 Wang Q. and Wieder R. (Oncogene 2004)
    843. The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. (PubMed id 15356200)9 Okuno S....Chan P.H. (J. Neurosci. 2004)
    844. Phosphorylation of JNK is involved in regulation of H(+)-induced c-Jun expression. (PubMed id 15093613)9 Shimokawa N....Koibuchi N. (Cell. Signal. 2004)
    845. Disruption of basal JNK activity differentially affects key fibroblast functions important for wound healing. (PubMed id 12730213)9 Javelaud D....Mauviel A. (J. Biol. Chem. 2003)
    846. Extracellular signal-regulated kinase and c-Src, but not Jun N-terminal kinase, are involved in basal and gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone alpha-subunit promoter. (PubMed id 12538624)9 Harris D....Naor Z. (Endocrinology 2003)
    847. Differential contribution of three mitogen-activated protein kinases to PDGF-BB-induced mesangial cell proliferation and gene expression. (PubMed id 12595493)9 Kawano H....Iwao H. (J. Am. Soc. Nephrol. 2003)
    848. Transient co-localization of c-Jun N-terminal kinase and c-Jun with heat shock protein 70 in pulp cells during apoptosis. (PubMed id 12562879)9 Kitamura C....Terashita M. (J. Dent. Res. 2003)
    849. Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models. (PubMed id 14654364)9 Liang Q. and Molkentin J.D. (J. Mol. Cell. Cardiol. 2003)
    850. Activation of the stress-activated JNK and p38 MAP kinases in human cells by Photofrin-mediated photodynamic therapy. (PubMed id 14705642)9 Tong Z....Rainbow A.J. (J. Photochem. Photobiol. B, Biol. 2003)
    851. Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation. (PubMed id 12738790)9 Hung C.C....Bonventre J.V. (J. Biol. Chem. 2003)
    852. Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways. (PubMed id 12374624)9 Lee K. and Esselman W.J. (amp 2002)
    853. Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells. (PubMed id 11856743)9 Mc Gee M.M....Zisterer D.M. (J. Biol. Chem. 2002)
    854. Inhibition of c-Jun N-terminal kinase ameliorates apoptosis induced by hydrogen peroxide in the kidney tubule epithelial cells (NRK-52E). (PubMed id 12021531)9 Wang L....Takeda M. (Nephron 2002)
    855. The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. (PubMed id 12417721)9 Reuther-Madrid J.Y....Baldwin Jr A.S. (Mol. Cell. Biol. 2002)
    856. Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis. (PubMed id 11948429)9 Hochedlinger K....Sabapathy K. (Oncogene 2002)
    857. Menadione biphasically controls JNK-linked cell death in leukemia Jurkat T cells. (PubMed id 12215205)9 Ma X....Nagase F. (amp 2002)
    858. Static stretch increases c-Jun NH2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle. (PubMed id 11208531)9 Boppart M.D....Goodyear L.J. (Am. J. Physiol., Cell Physiol. 2001)
    859. Interleukin-1beta stimulation of c-Jun NH(2)-terminal kinase activity in insulin-secreting cells: evidence for cytoplasmic restriction. (PubMed id 11723054)9 Major C.D. and Wolf B.A. (Diabetes 2001)
    860. Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. (PubMed id 11410534)9 Ciapponi L....Bohmann D. (amp 2001)
    861. Amantadine inhibits RANTES production by influenzavirus-infected human bronchial epithelial cells. (PubMed id 11181433)9 Asai Y....Horie T. (Br. J. Pharmacol. 2001)
    862. Natriuretic peptides suppress vascular endothelial cell growth factor signaling to angiogenesis. (PubMed id 11250939)9 Pedram A....Levin E.R. (Endocrinology 2001)
    863. Involvement of the extracellular signal-regulated protein kinase (ERK) pathway in the induction of apoptosis by cadmium chloride in CCRF-CEM cells. (PubMed id 11108803)9 Iryo Y....Igisu H. (Biochem. Pharmacol. 2000)
    864. 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity. (PubMed id 10807930)9 Zhou H....Chiu R. (J. Biol. Chem. 2000)
    865. Selective activation of the c-Jun N-terminal protein kinase pathway during 4-hydroxynonenal-induced apoptosis of PC12 cells. (PubMed id 10953046)9 Soh Y....Song B.J. (Mol. Pharmacol. 2000)
    866. Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades. (PubMed id 10329689)9 Blaukat A....Dikic I. (J. Biol. Chem. 1999)
    867. The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity. (PubMed id 10506143)9 Zheng C....Lin A. (J. Biol. Chem. 1999)
    868. Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance. (PubMed id 10037172)9 Johnston S.R....Benz C.C. (Clin. Cancer Res. 1999)
    869. Mitogen-activated protein kinase (p38-, JNK-, ERK-) activation pattern induced by extracellular and intracellular singlet oxygen and UVA. (PubMed id 10103024)9 Klotz L.O....Sies H. (Eur. J. Biochem. 1999)
    870. The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. (PubMed id 9860979)9 Dolfi F....Vuori K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    871. Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase. (PubMed id 9482836)9 Rogatsky I....Garabedian M.J. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    872. Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation. (PubMed id 9756915)9 Pedram A....Levin E.R. (J. Biol. Chem. 1998)
    873. Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation. (PubMed id 9731042)9 Nagata Y....Todokoro K. (Blood 1998)
    874. Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway. (PubMed id 9252389)9 Coso O.A....Gutkind J.S. (J. Biol. Chem. 1997)
    875. Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase. (PubMed id 8875991)9 Fuchs S.Y....Ronai Z. (Oncogene 1996)
    876. Galpha12 and Galpha13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells. (PubMed id 8702875)9 Voyno-Yasenetskaya T.A....Bourne H.R. (J. Biol. Chem. 1996)
    877. Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1. (PubMed id 8674048)9 Yu R....Kong A.N. (Cancer Res. 1996)
    878. Fibroblast growth factor-2 suppression of tumor necrosis factor alpha-mediated apoptosis requires Ras and the activation of mitogen-activated protein kinase. (PubMed id 8662985)9 Gardner A.M. and Johnson G.L. (J. Biol. Chem. 1996)
    879. Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts. (PubMed id 19772524)9 He S....Roberts M.S. (Br. J. Dermatol. 2010)
    880. Increased ERK and JNK activities correlate with disease activity in patients with systemic lupus erythematosus. (PubMed id 19158114)9 Molad Y....Rapoport M.J. (Ann. Rheum. Dis. 2010)
    881. Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes. (PubMed id 20074581)9 Huang H.S....Hong D.Y. (Toxicol. Appl. Pharmacol. 2010)
    882. Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress. (PubMed id 19270531)9 Dasmahapatra G....Grant S. (amp 2009)
    883. Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase. (PubMed id 19175673)9 Takeuchi K....Ito F. (FEBS J. 2009)
    884. Role of oxidation-triggered activation of JNK and p38 MAPK in black tea polyphenols induced apoptotic death of A375 cells. (PubMed id 19594545)9 Bhattacharya U....Giri A.K. (Cancer Sci. 2009)
    885. Constitutive activation of c-Jun N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas. (PubMed id 18246408)9 Li J.Y....Wang H. (J. Neurooncol. 2008)
    886. 4-Aryl-1,3,2-oxathiazolylium-5-olate: a novel GST inhibitor to release JNK and activate c-Jun for cancer therapy. (PubMed id 18008069)9 Cui H....Wang P.G. (Cancer Chemother. Pharmacol. 2008)
    887. Thymosin Beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation. (PubMed id 18094619)9 Zhang Y....Li M. (amp 2008)
    888. Induction of IL-8 in periodontal ligament cells by H(2)O (2). (PubMed id 18974961)9 Lee Y.S....Yoo Y.J. (J. Microbiol. 2008)
    889. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. (PubMed id 18270325)9 Chen C.L....Lin Y.S. (Blood 2008)
    890. Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor. (PubMed id 18552402)9 Alter J....Bengal E. (J. Biol. Chem. 2008)
    891. ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses. (PubMed id 18249159)9 Hamdi M....van Dam H. (DNA Repair (Amst.) 2008)
    892. Induction of G2/M arrest, endoreduplication, and apoptosis by actin depolymerization agent pextenotoxin-2 in human leukemia cells, involving activation of ERK and JNK. (PubMed id 18571148)9 Moon D.O....Kim G.Y. (Biochem. Pharmacol. 2008)
    893. Critical roles for JNK, c-Jun, and Fas/FasL-Signaling in vitamin E analog-induced apoptosis in human prostate cancer cells. (PubMed id 18196534)9 Jia L....Kline K. (Prostate 2008)
    894. SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes. (PubMed id 18655782)9 Henklova P....Dvorak Z. (Eur. J. Pharmacol. 2008)
    895. [Signal transduction in respiratory syncytial virus infection-induced thymic stromal lymphopoietin expression in human epithelial cells]. (PubMed id 17959543)9 Tu H.Y....Li J. (Nan Fang Yi Ke Da Xue Xue Bao 2007)
    896. Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. (PubMed id 17828457)9 SA!nchez A.M....DA-az-Laviada I. (Apoptosis 2007)
    897. Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling. (PubMed id 17673542)9 Meng D....Nanthakumar N.N. (Am. J. Physiol. Gastrointest. Liver Physiol. 2007)
    898. Dexamethasone suppresses interleukin-1beta-induced human beta-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-kappaB transcriptional factor in A549 cells. (PubMed id 17645739)9 Jang B.C....Suh S.I. (FEMS Immunol. Med. Microbiol. 2007)
    899. Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the Jun N-terminal kinase. (PubMed id 17322004)9 Korhonen R....Kleinert H. (Mol. Pharmacol. 2007)
    900. alpha-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner. (PubMed id 16839662)9 Zhao Y....Wu K. (Cancer Lett. 2007)
    901. Activation of MKK4 (SEK1), JNK, and c-Jun in labial salivary infiltrating T cells in patients with SjAPgren's syndrome. (PubMed id 17009014)9 Soejima K....Eguchi K. (Rheumatol. Int. 2007)
    902. Biphasic effect of arsenite on cell proliferation and apoptosis is associated with the activation of JNK and ERK1/2 in human embryo lung fibroblast cells. (PubMed id 17289100)9 He X.Q....Liu Q.Z. (Toxicol. Appl. Pharmacol. 2007)
    903. Apoptosis induced by the monomers HEMA and TEGDMA involves formation of ROS and differential activation of the MAP-kinases p38, JNK and ERK. (PubMed id 16430953)9 Samuelsen J.T....Becher R. (Dent Mater 2007)
    904. Regulation of TGF-beta1/MAPK-mediated PAI-1 gene expression by the actin cytoskeleton in human mesangial cells. (PubMed id 17328891)9 Yang C....Glass W.F. (Exp. Cell Res. 2007)
    905. C-jun N-terminal kinase activation is required for apoptotic cell death induced by TNF-related apoptosis-inducing ligand plus DNA-damaging agents in sarcoma cell lines. (PubMed id 16619517)9 Mikami T....Mizuguchi J. (Anticancer Res. 2006)
    906. The role of MAPKs in B cell receptor-induced down-regulation of Egr-1 in immature B lymphoma cells. (PubMed id 17065146)9 Ke J....Bondada S. (J. Biol. Chem. 2006)
    907. No evidence for an involvement of the p38 and JNK mitogen-activated protein in inflammatory bowel diseases. (PubMed id 16838116)9 Malamut G....Desreumaux P. (Dig. Dis. Sci. 2006)
    908. Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway. (PubMed id 17068110)9 Stagi M....Neumann H. (FASEB J. 2006)
    909. c-Jun NH2-terminal kinase/c-Jun signaling promotes survival and metastasis of B lymphocytes transformed by Theileria. (PubMed id 16778183)9 Lizundia R....Langsley G. (Cancer Res. 2006)
    910. Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. (PubMed id 17065531)9 Qin S....De Vries G.W. (amp 2006)
    911. Osmotic stress activates the TAK1-JNK pathway while blocking TAK1- mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. (PubMed id 16893890)9 Huangfu W.C.... Ninomiya-Tsuji J. (J. Biol. Chem. 2006)
    912. Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia. (PubMed id 16457791)9 Uesugi M....Kurihara T. (Brain Res. 2006)
    913. Histamine differentially interacts with tumor necrosis factor-alpha and thrombin in endothelial tissue factor induction: the role of c-Jun NH2-terminal kinase. (PubMed id 16938121)9 Steffel J....Tanner F.C. (J. Thromb. Haemost. 2006)
    914. Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. (PubMed id 16150723)9 Uhlirova M....Bohmann D. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    915. Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in beta-amyloid peptide-dependent cell death. (PubMed id 15784962)9 Costantini C....Della-Bianca V. (J. Mol. Neurosci. 2005)
    916. Integration of G protein signals by extracellular signal-regulated protein kinases in SK-N-MC neuroepithelioma cells. (PubMed id 15992362)9 Chan A.S....Wong Y.H. (J. Neurochem. 2005)
    917. Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes. (PubMed id 16258191)9 Nieminen R....Moilanen E. (Mediators Inflamm. 2005)
    918. ERK2 is required for FGF1-induced JNK1 phosphorylation in Xenopus oocyte expressing FGF receptor 1. (PubMed id 15777834)9 Browaeys-Poly E....Cailliau K. (Biochim. Biophys. Acta 2005)
    919. JNK activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis. (PubMed id 15917192)9 Handley M.E....Katz D.R. (amp 2005)
    920. Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells. (PubMed id 15001544)9 Andreozzi F....Sesti G. (Endocrinology 2004)
    921. Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand. (PubMed id 15585853)9 Singh R.A. and Zhang J.Z. (J. Immunol. 2004)
    922. Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells. (PubMed id 14720501)9 Yoshizumi M....Tamaki T. (Exp. Cell Res. 2004)
    923. Heat shock-induced matrix metalloproteinase (MMP)-1 and MMP-3 are mediated through ERK and JNK activation and via an autocrine interleukin-6 loop. (PubMed id 15610507)9 Park C.H....Chung J.H. (J. Invest. Dermatol. 2004)
    924. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. (PubMed id 15350216)9 Sabapathy K....Wagner E.F. (Mol. Cell 2004)
    925. Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK1/2) in an experimental model of cerulein-induced pancreatitis. (PubMed id 15454338)9 Minutoli L....Squadrito F. (Life Sci. 2004)
    926. c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK). (PubMed id 15378002)9 Sevilla A....Lazo P.A. (Oncogene 2004)
    927. MAP kinase pathways involved in glioblastoma response to erucylphosphocholine. (PubMed id 15547710)9 Kugler W....Lakomek M. (Int. J. Oncol. 2004)
    928. Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells. (PubMed id 12970086)9 Chen Y.N....Hsu S.L. (Br. J. Pharmacol. 2003)
    929. Jun N-terminal kinase pathway enhances signaling of monocytic differentiation of human leukemia cells induced by 1,25-dihydroxyvitamin D3. (PubMed id 12898508)9 Wang Q....Studzinski G.P. (J. Cell. Biochem. 2003)
    930. JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun. (PubMed id 12853483)9 Weiss C....Bohmann D. (EMBO J. 2003)
    931. Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. (PubMed id 12637505)9 Mansouri A....Claret F.X. (J. Biol. Chem. 2003)
    932. Regulation of necrosis of H9c2 myogenic cells upon transient energy deprivation. Rapid deenergization of mitochondria precedes necrosis and is controlled by reactive oxygen species, stress kinase JNK, HSP72 and ARC. (PubMed id 14523009)9 Yaglom J.A....Sherman M.Y. (J. Biol. Chem. 2003)
    933. Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway. (PubMed id 12968928)9 Tomita M....Sakai K. (Radiat. Res. 2003)
    934. Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1. (PubMed id 12723971)9 Song J.J. and Lee Y.J. (Biochem. J. 2003)
    935. Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK. (PubMed id 12555071)9 Antlsperger D.S....Vollmar A.M. (Oncogene 2003)
    936. Regulation of MAPK signaling pathways through immunophilin-ligand complex. (PubMed id 12871167)9 Matsuda S. and Koyasu S. (Curr Top Med Chem 2003)
    937. Involvement of c-jun N-terminal kinase activation in 15-deoxy-delta12,14-prostaglandin J2-and prostaglandin A1-induced apoptosis in AGS gastric epithelial cells. (PubMed id 12720296)9 Liu J.D....Liang Y.C. (Mol. Carcinog. 2003)
    938. Involvement of mitogen-activated protein kinases in Group B Streptococcus-induced macrophage apoptosis. (PubMed id 12644394)9 Fettucciari K....Marconi P. (Pharmacol. Res. 2003)
    939. Non-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to edelfosine-induced cell death and different cell line-specific responses to edelfosine treatment. (PubMed id 12851688)9 Shafer S.H. and Williams C.L. (Int. J. Oncol. 2003)
    940. The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. (PubMed id 12819185)9 Hu R....Kong A.N. (Carcinogenesis 2003)
    941. Inhibition by dexamethasone of interleukin 13 production via glucocorticoid receptor-mediated inhibition of c-Jun phosphorylation. (PubMed id 14623117)9 Hirasawa N....Ohuchi K. (FEBS Lett. 2003)
    942. Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. (PubMed id 12171915)9 Chen Y.R....Tan T.H. (J. Biol. Chem. 2002)
    943. Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis. (PubMed id 12018840)9 Koo M.S....Kim Y.M. (Mol. Cells 2002)
    944. Regulation of human airway epithelial cell IL-8 expression by MAP kinases. (PubMed id 12225945)9 Li J....Hershenson M.B. (Am. J. Physiol. Lung Cell Mol. Physiol. 2002)
    945. IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibroblasts through c-Jun NH2-terminal kinase-dependent pathway. (PubMed id 11398077)9 Hashimoto S....Horie T. (J. Allergy Clin. Immunol. 2001)
    946. Activation of MAPKs by angiotensin II in vascular smooth muscle cells. Metalloprotease-dependent EGF receptor activation is required for activation of ERK and p38 MAPK but not for JNK. (PubMed id 11116149)9 Eguchi S....Inagami T. (J. Biol. Chem. 2001)
    947. Implication of a small GTPase Rac1 in the activation of c-Jun N-terminal kinase and heat shock factor in response to heat shock. (PubMed id 11050083)9 Han S.I....Kang H.S. (J. Biol. Chem. 2001)
    948. Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway. (PubMed id 11641785)9 Lafarge S....Bignon Y.J. (Oncogene 2001)
    949. Insulin regulates MAP kinase phosphatase-1 induction in Hirc B cells via activation of both extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK). (PubMed id 11330828)9 Byon J.C....Kusari J. (Mol. Cell. Biochem. 2001)
    950. Apoptosis of PC12 cells by 4-hydroxy-2-nonenal is mediated through selective activation of the c-Jun N-terminal protein kinase pathway. (PubMed id 11306108)9 Song B.J....Jeong K. (Chem. Biol. Interact. 2001)
    951. Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells. (PubMed id 11160861)9 Shiah S.G....Kuo M.L. (Mol. Pharmacol. 2001)
    952. Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylation. (PubMed id 11425893)9 Figueroa-Masot X.A....Xia Z. (J. Neurosci. 2001)
    953. Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis. (PubMed id 11083274)9 Schett G....Steiner G. (Arthritis Rheum. 2000)
    954. Tensin can induce JNK and p38 activation. (PubMed id 10860821)9 Katz B.Z....Yamada K.M. (Biochem. Biophys. Res. Commun. 2000)
    955. Marathon running transiently increases c-Jun NH2-terminal kinase and p38 activities in human skeletal muscle. (PubMed id 10922016)9 Boppart M.D....Goodyear L.J. (J. Physiol. (Lond.) 2000)
    956. Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. (PubMed id 10734112)9 Yu R....Kong A.N. (J. Biol. Chem. 2000)
    957. p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells. (PubMed id 10706714)9 Kujime K....Horie T. (J. Immunol. 2000)
    958. The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses. (PubMed id 10924852)9 RincA^n M....Davis R.A. (amp 2000)
    959. Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways? (PubMed id 10762418)9 RincA^n M....Davis R.J. (Immunol. Cell Biol. 2000)
    960. Role of caspases in dexamethasone-induced apoptosis and activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase in human eosinophils. (PubMed id 11012613)9 Zhang J.P....Lam C.W. (Clin. Exp. Immunol. 2000)
    961. Activation of c-Jun N-terminal kinase and activator protein 1 by receptor activator of nuclear factor kappaB. (PubMed id 11093794)9 Lee Z.H....Kim H.H. (Mol. Pharmacol. 2000)
    962. c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells. (PubMed id 10825181)9 Potapova O....Holbrook N.J. (J. Biol. Chem. 2000)
    963. Cisplatin-induced response of c-jun N-terminal kinase 1 and extracellular signal--regulated protein kinases 1 and 2 in a series of cisplatin-resistant ovarian carcinoma cell lines. (PubMed id 11170260)9 Cui W....Persons D.L. (Mol. Carcinog. 2000)
    964. Induction of apoptosis by dexrazoxane (ICRF-187) through caspases in the absence of c-jun expression and c-Jun NH2-terminal kinase 1 (JNK1) activation in VM-26-resistant CEM cells. (PubMed id 10487526)9 KhAclifa T. and Beck W.T. (Biochem. Pharmacol. 1999)
    965. Expression of mitogen activated protein kinases in labial salivary glands of patients with SjAPgren's syndrome. (PubMed id 10340964)9 Nakamura H....Eguchi K. (Ann. Rheum. Dis. 1999)
    966. Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin. (PubMed id 10353733)9 Persons D.L....Pelling J.C. (Clin. Cancer Res. 1999)
    967. Association of apoptosis with the inhibition of extracellular signal-regulated protein kinase activity in the tumor necrosis factor alpha-resistant ovarian carcinoma cell line UCI 101. (PubMed id 10331740)9 Yazlovitskaya E.M....Persons D.L. (Mol. Carcinog. 1999)
    968. Requirement of Erk, but not JNK, for arsenite-induced cell transformation. (PubMed id 10329651)9 Huang C....Dong Z. (J. Biol. Chem. 1999)
    969. Regulation of the c-jun gene in p210 BCR-ABL transformed cells corresponds with activity of JNK, the c-jun N-terminal kinase. (PubMed id 9746785)9 Burgess G.S....Boswell H.S. (Blood 1998)
    970. Analysis of human breast adenocarcinoma MCF7 resistance to tumor necrosis factor-induced cell death. Lack of correlation between JNK activation and ceramide pathway. (PubMed id 9786905)9 Ameyar M....ChouaA^b S. (J. Biol. Chem. 1998)
    971. Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK). (PubMed id 9774447)9 Lee L.F....Ting J.P. (J. Biol. Chem. 1998)
    972. Activation of c-Jun NH2-terminal kinases by interleukin-1 beta in normal human osteoblastic and rat UMR-106 cells. (PubMed id 9513050)9 Chaudhary L.R. and Avioli L.V. (J. Cell. Biochem. 1998)
    973. Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells. (PubMed id 9488042)9 Watabe M....Nakaya K. (Oncogene 1998)
    974. The mitogen-activated protein kinase pathway inhibits ceramide-induced terminal differentiation of a human monoblastic leukemia cell line, U937. (PubMed id 9686602)9 Ragg S.J....Ochi A. (J. Immunol. 1998)
    975. Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts. (PubMed id 9188778)9 Klotz L.O....Sies H. (FEBS Lett. 1997)
    976. Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis. (PubMed id 9010448)9 Magi-Galluzzi C....Loda M. ( a journal of technical methods and pathology 1997)
    977. Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants. (PubMed id 9360968)9 Yu R....Kong A.N. (J. Biol. Chem. 1997)
    978. Selective inhibition of oncogenic ras-p21 in vivo by agents that block its interaction with jun-N-kinase (JNK) and jun proteins. Implications for the design of selective chemotherapeutic agents. (PubMed id 9443618)9 Amar S....Pincus M.R. (Cancer Chemother. Pharmacol. 1997)
    979. Low extracellular pH induces activation of ERK 2, JNK, and p38 in A431 and Swiss 3T3 cells. (PubMed id 9425256)9 Xue L. and Lucocq J.M. (Biochem. Biophys. Res. Commun. 1997)
    980. Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes. (PubMed id 8941662)9 Geng Y....Lotz M. (J. Clin. Invest. 1996)
    981. Differential activation of mitogen-activated protein kinases by nitric oxide-related species. (PubMed id 8702674)9 Lander H.M....Tauras J.M. (J. Biol. Chem. 1996)
    982. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. (PubMed id 8626452)9 Chu Y.... Kelly K. (J. Biol. Chem. 1996)
    983. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. (PubMed id 7929360)9 Westwick J.K....Brenner D.A. (J. Biol. Chem. 1994)
    984. TRAF2-MLK3 interaction is essential for TNF-alpha-induced MLK3 activation. (PubMed id 19918265)9 Sondarva G.... Rana A. (Cell Res. 2010)
    985. TGF-beta stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2. (PubMed id 20213272)9 Burch M.L....Little P.J. (Cell. Mol. Life Sci. 2010)
    986. SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition. (PubMed id 20062077)9 Kim J.A....Fotedar R. (Oncogene 2010)
    987. SIAH1 induced apoptosis by activation of the JNK pathway and inhibited invasion by inactivation of the ERK pathway in breast cancer cells. (PubMed id 19775288)9 Wen Y.Y....Wang E.H. (Cancer Sci. 2010)
    988. Tumor inhibition by sodium selenite is associated with activation of c-Jun NH2-terminal kinase 1 and suppression of beta-catenin signaling. (PubMed id 19904745)9 Fang W....Yang W. (Int. J. Cancer 2010)
    989. Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism. (PubMed id 20103766)9 Simard J.C.... Tessier P.A. (J. Leukoc. Biol. 2010)
    990. Intracellular chloride regulates cell proliferation through the activation of stress-activated protein kinases in MKN28 human gastric cancer cells. (PubMed id 20205250)9 Ohsawa R....Marunaka Y. (J. Cell. Physiol. 2010)
    991. Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling. (PubMed id 20158498)9 Liou G.Y....Gallo K.A. (Biochem. J. 2010)
    992. Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling. (PubMed id 19777565)9 Deng Y.T....Lin J.K. (Mol. Carcinog. 2010)
    993. C-jun N-terminal kinase-mediated signaling is essential for Staphylococcus aureus-induced U937 apoptosis. (PubMed id 19382420)9 Wang J.H....He P. (Chin. Med. Sci. J. 2009)
    994. Ricin A-chain requires c-Jun N-terminal kinase to induce apoptosis in nontransformed epithelial cells. (PubMed id 19695342)9 Jetzt A.E....Cohick W.S. (amp 2009)
    995. Mitogen activated protein kinases in renal fibrosis. (PubMed id 19482693)9 Ma F.Y....Nikolic-Paterson D.J. (Front Biosci (Schol Ed) 2009)
    996. Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation. (PubMed id 20501438)9 Singh R....Czaja M.J. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    997. [Gene profiling of MAPK pathway in human osteosarcoma]. (PubMed id 19799081)9 Li G.D....Zhang Q.L. (Zhonghua Zhong Liu Za Zhi 2009)
    998. Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L. (PubMed id 19321614)9 Zhang P....Samuel C.E. (J. Virol. 2009)
    999. Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis. (PubMed id 19427996)9 Chu R....Chambers T.C. (Biochem. Pharmacol. 2009)
    1000. Oncogenic ILK, tumor suppression and all that JNK. (PubMed id 19923885)9 Durbin A.D....Malkin D. (Cell Cycle 2009)
    1001. Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma. (PubMed id 19418558)9 Nagata H....Uemoto S. (Hepatology 2009)
    1002. Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer. (PubMed id 19048624)9 Yagi H....Miyamoto S. (Int. J. Cancer 2009)
    1003. c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells. (PubMed id 19706754)9 Lorin S....Djavaheri-Mergny M. (Cancer Res. 2009)
    1004. Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer. (PubMed id 19522739)9 Joo S.S. and Yoo Y.M. (J. Pineal Res. 2009)
    1005. A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK. (PubMed id 19888449)9 Geuking P....Leulier F. (PLoS ONE 2009)
    1006. Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. (PubMed id 19106158)9 Tanemura S....Nishina H. (J. Biochem. 2009)
    1007. (-)-Epigallocatechin-3-gallate induces up-regulation of Th1 and Th2 cytokine genes in Jurkat T cells. (PubMed id 19135025)9 Wu H....Nakamura Y. (Arch. Biochem. Biophys. 2009)
    1008. Constitutive and oxidative-stress-induced expression of VEGF in the RPE are differently regulated by different Mitogen-activated protein kinases. (PubMed id 19603178)9 Klettner A. and Roider J. (Graefes Arch. Clin. Exp. Ophthalmol. 2009)
    1009. N-acetyl cysteine mediates protection from 2-hydroxyethyl methacrylate induced apoptosis via nuclear factor kappa B-dependent and independent pathways: potential involvement of JNK. (PubMed id 19176594)9 Paranjpe A....Jewett A. (Toxicol. Sci. 2009)
    1010. Prolactin enhances basal and IL-17-induced CCL20 production by human keratinocytes. (PubMed id 19350575)9 Kanda N....Watanabe S. (Eur. J. Immunol. 2009)
    1011. Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney cancer cells by suppression of BAG3 expression. (PubMed id 19681889)9 Wang H.Q....Du Z.X. (Br. J. Pharmacol. 2009)
    1012. Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion. (PubMed id 19920350)9 Qi D....Young L.H. (J. Clin. Invest. 2009)
    1013. Cadmium stimulates the expression of vascular cell adhesion molecule-1 (VCAM-1) via p38 mitogen-activated protein kinase (MAPK) and JNK activation in cerebrovascular endothelial cells. (PubMed id 19609071)9 Park S.L....Jung Y.S. (J. Pharmacol. Sci. 2009)
    1014. Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. (PubMed id 19445931)9 Gao Y.J....Ji R.R. (Exp. Neurol. 2009)
    1015. Amyloid beta interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier. (PubMed id 19380826)9 Li M....Chen Y.H. (J. Immunol. 2009)
    1016. Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway. (PubMed id 19486902)9 Zhou C.H....Wu Y.Q. (Eur. J. Pharmacol. 2009)
    1017. Involvement of mitogen-activated protein kinase signaling in growth and rupture of human intracranial aneurysms. (PubMed id 18239167)9 Laaksamo E....Laakso A. ( a journal of cerebral circulation 2008)
    1018. Inhibition of the lipopolysaccharide-induced stimulation of the members of the MAPK family in human monocytes/macrophages by 4-hydroxynonenal, a product of oxidized omega-6 fatty acids. (PubMed id 18772336)9 Marantos C....Ferrante A. (Am. J. Pathol. 2008)
    1019. Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2. (PubMed id 18068334)9 Selimovic D....Hengge U.R. (Cell. Signal. 2008)
    1020. VEGF and thrombin induce MKP-1 through distinct signaling pathways: role for MKP-1 in endothelial cell migration. (PubMed id 18003751)9 Kinney C.M....DiCorleto P.E. (Am. J. Physiol., Cell Physiol. 2008)
    1021. Growth-arrest-dependent expression and phosphorylation of p27kip at serine10 is mediated by the JNK pathway in C6 glioma cells. (PubMed id 18513991)9 Mielke K. (Mol. Cell. Neurosci. 2008)
    1022. Minocycline protects melanocytes against H2O2-induced cell death via JNK and p38 MAPK pathways. (PubMed id 18575770)9 Song X....Wan Y. (Int. J. Mol. Med. 2008)
    1023. Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNK-dependent mechanism. (PubMed id 18234850)9 Crisostomo P.R....Meldrum D.R. (Am. J. Physiol., Cell Physiol. 2008)
    1024. Role of JNK-dependent serine phosphorylation of paxillin in migration of corneal epithelial cells during wound closure. (PubMed id 18172084)9 Kimura K....Nishida T. (amp 2008)
    1025. Amplification of the gamma-irradiation-induced cell death pathway by reactive oxygen species in human U937 cells. (PubMed id 18262755)9 Kim E.M....Um H.D. (Cell. Signal. 2008)
    1026. Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells. (PubMed id 18768478)9 Xiao D....Singh S.V. (J. Biol. Chem. 2008)
    1027. Dexamethasone-induced expression of endothelial mitogen-activated protein kinase phosphatase-1 involves activation of the transcription factors activator protein-1 and 3',5'-cyclic adenosine 5'-monophosphate response element-binding protein and the generation of reactive oxygen species. (PubMed id 18403484)9 FA1rst R....Vollmar A.M. (Endocrinology 2008)
    1028. Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism. (PubMed id 18222647)9 Muniyappa H. and Das K.C. (Cell. Signal. 2008)
    1029. Long-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death. (PubMed id 19967054)9 Seok J.H....Hur G.M. (amp 2008)
    1030. TNF alpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappa B-dependent pathways. (PubMed id 18061162)9 Rivas M.A....Schillaci R. (Exp. Cell Res. 2008)
    1031. TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation. (PubMed id 18228247)9 Vanden Bush T.J. and Bishop G.A. (Eur. J. Immunol. 2008)
    1032. Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway. (PubMed id 18541231)9 Yu J....Ouchi Y. (Eur. J. Pharmacol. 2008)
    1033. Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition. (PubMed id 18316219)9 Kim H.L....Im D.S. (amp 2008)
    1034. Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases. (PubMed id 18467203)9 Brechter A.B....Lerner U.H. (Bone 2008)
    1035. Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanism. (PubMed id 18374905)9 Lee S. and Das H.K. (Brain Res. 2008)
    1036. Dexamethasone suppresses monocyte chemoattractant protein-1 production via mitogen activated protein kinase phosphatase-1 dependent inhibition of Jun N-terminal kinase and p38 mitogen-activated protein kinase in activated rat microglia. (PubMed id 17403137)9 Zhou Y....Dheen S.T. (J. Neurochem. 2007)
    1037. Simvastatin induces apoptosis in human breast cancer cells: p53 and estrogen receptor independent pathway requiring signalling through JNK. (PubMed id 17125918)9 Koyuturk M....Altiok N. (Cancer Lett. 2007)
    1038. Static strain stimulates expression of matrix metalloproteinase-2 and VEGF in microvascular endothelium via JNK- and ERK-dependent pathways. (PubMed id 17031856)9 Milkiewicz M....Haas T.L. (J. Cell. Biochem. 2007)
    1039. Calcium-mediated activation of PI3K and p53 leads to apoptosis in thyroid carcinoma cells. (PubMed id 17514353)9 Liu Z.M....van Hasselt C.A. (Cell. Mol. Life Sci. 2007)
    1040. Triptolide suppresses interleukin-1beta-induced human beta-defensin-2 mRNA expression through inhibition of transcriptional activation of NF-kappaB in A549 cells. (PubMed id 17390080)9 Jang B.C....Suh S.I. (Int. J. Mol. Med. 2007)
    1041. [c-Jun NH2-terminal kinase and extracellular signal-regulated protein kinase signaling pathways in regulation of benzo(a)pyrene-induced c-Jun activation in human embryo lung fibroblasts]. (PubMed id 17908424)9 Jiao S....Jia X.W. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2007)
    1042. Involvement of c-Jun-JNK pathways in the regulation of programmed cell death of developing chick embryo spinal cord motoneurons. (PubMed id 17119319)9 Ribera J....Casas C. (Dev. Neurosci. 2007)
    1043. Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing. (PubMed id 17525369)9 Garin G....Berk B.C. (Circ. Res. 2007)
    1044. Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. (PubMed id 17673978)9 Hsu W.H....Kuo W.H. (Arch. Toxicol. 2007)
    1045. Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells. (PubMed id 17974980)9 Nieto-Miguel T....Mollinedo F. (Cancer Res. 2007)
    1046. c-Jun N-terminal kinase mediates constitutive human eosinophil apoptosis. (PubMed id 16934508)9 Hasala H....Kankaanranta H. (amp 2007)
    1047. Induction of apoptosis and activation of JNK and p38 MAPK pathways in deoxynivalenol-treated cell lines. (PubMed id 17411352)9 Baltriukiene D....Bukelskiene V. (Altern Lab Anim 2007)
    1048. Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. (PubMed id 17210646)9 Lan H.-C.... Chung B.-C. (Mol. Cell. Biol. 2007)
    1049. TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1. (PubMed id 16876162)9 Soond S.M....Riches D.W. (FEBS Lett. 2006)
    1050. Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells. (PubMed id 16497702)9 Collett G.P. and Campbell F.C. (Carcinogenesis 2006)
    1051. JNK and AP-1 mediate apoptosis induced by bortezomib in HepG2 cells via FasL/caspase-8 and mitochondria-dependent pathways. (PubMed id 16528474)9 Lauricella M....Tesoriere G. (Apoptosis 2006)
    1052. Inactivation of Id-1 in prostate cancer cells: A potential therapeutic target in inducing chemosensitization to taxol through activation of JNK pathway. (PubMed id 16287090)9 Zhang X....Wong Y.C. (Int. J. Cancer 2006)
    1053. Apoptosis induced by chemotherapeutic agents involves c-Jun N-terminal kinase activation in sarcoma cell lines. (PubMed id 16705697)9 Koyama T....Mizuguchi J. (J. Orthop. Res. 2006)
    1054. Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells. (PubMed id 16336951)9 Wu G....Li J. (Cardiovasc. Res. 2006)
    1055. Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases. (PubMed id 16310883)9 Conde de la Rosa L....Moshage H. (J. Hepatol. 2006)
    1056. Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells. (PubMed id 16964394)9 Yoshino Y....Ohno K. (Int. J. Oncol. 2006)
    1057. The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. (PubMed id 16630028)9 Assi K....Salh B. (Immunology 2006)
    1058. Paclitaxel (Taxol) upregulates expression of functional interleukin-6 in human ovarian cancer cells through multiple signaling pathways. (PubMed id 16547493)9 Wang T.H....Wang H.S. (Oncogene 2006)
    1059. Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1 signaling. (PubMed id 16322078)9 Kutuk O....Basaga H. (Toxicol. Sci. 2006)
    1060. The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2. (PubMed id 16601071)9 Baan B....Ouwens D.M. (Mol. Endocrinol. 2006)
    1061. Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. (PubMed id 16928811)9 Xu C....Kong A.N. (Mol. Cancer Ther. 2006)
    1062. Constitutive signalling pathway activity in trabecular meshwork cells from glaucomatous eyes. (PubMed id 16516195)9 Zhang X....Fini M.E. (Exp. Eye Res. 2006)
    1063. Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia. (PubMed id 16571868)9 Thobe B.M....Chaudry I.H. (Am. J. Physiol., Cell Physiol. 2006)
    1064. Altered glucocorticoid receptor signaling cascade in lymphocytes of bipolar disorder patients. (PubMed id 16621324)9 Spiliotaki M....Moutsatsou P. (Psychoneuroendocrinology 2006)
    1065. A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action. (PubMed id 16516830)9 Lin A. (Dev. Cell 2006)
    1066. ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells. (PubMed id 16272172)9 Xu C....Kong A.N. (Carcinogenesis 2006)
    1067. Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. (PubMed id 16921400)9 Oak M.H....Schini-Kerth V.B. (Br. J. Pharmacol. 2006)
    1068. (+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation. (PubMed id 16564553)9 Wu W.B....Hung C.F. (Life Sci. 2006)
    1069. Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistance. (PubMed id 16951204)9 Wang Z....Wu G.S. (Cancer Res. 2006)
    1070. [Effects of magnetic field on MAPK signaling pathways of human retinal pigment epithelial cells bound with beads in vitro]. (PubMed id 17415968)9 Hou X....Guo C.M. (Zhonghua Yan Ke Za Zhi 2006)
    1071. Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways. (PubMed id 15767555)9 Hahn M....Grant S. (Mol. Cancer Ther. 2005)
    1072. 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process. (PubMed id 15782127)9 Gao N....Grant S. (Oncogene 2005)
    1073. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. (PubMed id 16085647)9 Nguyen M.T....Olefsky J.M. (J. Biol. Chem. 2005)
    1074. Pramanicin induces apoptosis in Jurkat leukemia cells: a role for JNK, p38 and caspase activation. (PubMed id 15909121)9 Kutuk O....Basaga H. (Apoptosis 2005)
    1075. The nonsteroidal anti-inflammatory drug Exisulind selectively induces apoptosis via JNK in secondary acute myeloid leukemia after myelodysplastic syndrome. (PubMed id 15970671)9 Czibere A....Aivado M. (Cell Cycle 2005)
    1076. The conditional kinase DeltaMEKK1:ER* selectively activates the JNK pathway and protects against serum withdrawal-induced cell death. (PubMed id 15893455)9 Molton S.A....Cook S.J. (Cell. Signal. 2005)
    1077. Tumor necrosis factor-alpha induces differentiation of human peripheral blood mononuclear cells into osteoclasts through the induction of p21(WAF1/Cip1). (PubMed id 15823554)9 Kwak H.B....Lee Z.H. (Biochem. Biophys. Res. Commun. 2005)
    1078. Protein kinase p-JNK is correlated with the activation of AP-1 and its associated Jun family proteins in hepatocellular carcinoma. (PubMed id 15927205)9 Guo L....Shi X. (Life Sci. 2005)
    1079. [Hypoxia stimulates expression of connective tissue growth factor through p38 signaling pathway in human renal interstitial fibroblasts]. (PubMed id 16086056)9 Rong L.L....Li J.Z. (Beijing Da Xue Xue Bao 2005)
    1080. Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells. (PubMed id 16000309)9 Murakami T....Yoshimura N. (J. Biol. Chem. 2005)
    1081. DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways. (PubMed id 15735741)9 Xue L....Bjeldanes L.F. (Oncogene 2005)
    1082. DNA damage and G2/M arrest in Syrian hamster embryo cells during Malachite green exposure are associated with elevated phosphorylation of ERK1 and JNK1. (PubMed id 16297712)9 Bose B....Rao K.V. (Cancer Lett. 2005)
    1083. Involvement of c-Jun NH2 terminal kinase and p38MAPK in rapamycin-mediated inhibition of neointimal formation in rat carotid arteries. (PubMed id 16160607)9 Omura T....Yoshikawa J. (J. Cardiovasc. Pharmacol. 2005)
    1084. Ventilation-induced neutrophil infiltration and apoptosis depend on apoptosis signal-regulated kinase 1 pathway. (PubMed id 16148459)9 Li L.F....Quinn D.A. (Crit. Care Med. 2005)
    1085. Inflammatory pathway analysis using a high content screening platform. (PubMed id 15971988)9 Bertelsen M. and Sanfridson A. (Assay Drug Dev Technol 2005)
    1086. DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1. (PubMed id 16044158)9 Hamdi M....van Dam H. (Oncogene 2005)
    1087. Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. (PubMed id 16000872)9 Cho J.W....Suh S.I. (amp 2005)
    1088. Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells. (PubMed id 14976342)9 Newhouse K....Xia Z. (Toxicol. Sci. 2004)
    1089. Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines. (PubMed id 14500571)9 Mabuchi S....Murata Y. (Endocrinology 2004)
    1090. Restoration of G1/S arrest in E1A+c-Ha-ras-transformed cells by Bcl-2 overexpression. (PubMed id 15492506)9 Nelyudova A.M....Pospelova T.V. (Cell Cycle 2004)
    1091. Inhibitory effect of epigallocatechin 3-O-gallate on vascular smooth muscle cell hypertrophy induced by angiotensin II. (PubMed id 14716206)9 Zheng Y....Ahn H.Y. (J. Cardiovasc. Pharmacol. 2004)
    1092. Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner. (PubMed id 15117824)9 Zhang R....Min W. (Circ. Res. 2004)
    1093. JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). (PubMed id 15138488)9 Ikezoe T....Koeffler H.P. (Br. J. Cancer 2004)
    1094. JNK-dependent phosphorylation of c-Jun on serine 63 mediates nitric oxide-induced apoptosis of neuroblastoma cells. (PubMed id 14617628)9 Li L....Porter A.G. (J. Biol. Chem. 2004)
    1095. Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. (PubMed id 14615289)9 Kohlstedt K....Fleming I. (Circ. Res. 2004)
    1096. c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells. (PubMed id 15069708)9 Wu K....Yu W.P. (World J. Gastroenterol. 2004)
    1097. Role of mitogen-activated protein kinase in the regulation of transforming growth factor-beta-induced fibronectin accumulation in cultured renal interstitial fibroblasts. (PubMed id 15480895)9 Suzuki H....Nihei H. (Clin. Exp. Nephrol. 2004)
    1098. Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. (PubMed id 14661062)9 Woo J.H....Kwon T.K. (Oncogene 2004)
    1099. Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK. (PubMed id 15304089)9 BoislA"ve F....Pallardy M. (J. Invest. Dermatol. 2004)
    1100. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. (PubMed id 14766793)9 Schwabe R.F....Brenner D.A. (FASEB J. 2004)
    1101. JNK and p38 MAP kinases in CD4+ and CD8+ T cells. (PubMed id 12670401)9 RincA^n M. and Pedraza-Alva G. (Immunol. Rev. 2003)
    1102. Role of mitogen-activated protein kinases in influenza virus induction of prostaglandin E2 from arachidonic acid in bronchial epithelial cells. (PubMed id 12956746)9 Mizumura K....Horie T. (Clin. Exp. Allergy 2003)
    1103. Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation. (PubMed id 12709432)9 Xu Z....Ip N.Y. (J. Biol. Chem. 2003)
    1104. Phenyl N-tert-butylnitrone down-regulates interleukin-1 beta-stimulated matrix metalloproteinase-13 gene expression in human chondrocytes: suppression of c-Jun NH2-terminal kinase, p38-mitogen-activated protein kinase and activating protein-1. (PubMed id 12626640)9 Ahmed S....Haqqi T.M. (J. Pharmacol. Exp. Ther. 2003)
    1105. Epigallocatechin-3-gallate selectively inhibits interleukin-1beta-induced activation of mitogen activated protein kinase subgroup c-Jun N-terminal kinase in human osteoarthritis chondrocytes. (PubMed id 12507586)9 Singh R....Haqqi T.M. (J. Orthop. Res. 2003)
    1106. The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner. (PubMed id 12944913)9 ElsAosser A....Behre G. (Oncogene 2003)
    1107. The role of JNK and p38 MAPK activities in UVA-induced signaling pathways leading to AP-1 activation and c-Fos expression. (PubMed id 14511403)9 Silvers A.L....Bowden G.T. (Neoplasia 2003)
    1108. Nuclear factor-kappa B and mitogen-activated protein kinases mediate nitric oxide-enhanced transcriptional expression of interferon-beta. (PubMed id 12500976)9 Jacobs A.T. and Ignarro L.J. (J. Biol. Chem. 2003)
    1109. Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN delta domain induces apoptosis and affects a distinct set of interleukin-1-induced inflammatory genes. (PubMed id 12832416)9 Holzberg D....Kracht M. (J. Biol. Chem. 2003)
    1110. Oncogenic effect of delta deletion in v-Jun does not result from uncoupling Jun from JNK signaling. (PubMed id 12555063)9 Sprowles A. and Wisdom R. (Oncogene 2003)
    1111. Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process. (PubMed id 14562039)9 Dai Y....Grant S. (Oncogene 2003)
    1112. Constitutively active forms of c-Jun NH2-terminal kinase are expressed in primary glial tumors. (PubMed id 12517805)9 Tsuiki H....Wong A.J. (Cancer Res. 2003)
    1113. Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis. (PubMed id 14560924)9 Kim D.S....Park K.C. (Arch. Pharm. Res. 2003)
    1114. A central role for the JNK pathway in mediating the antagonistic activity of pro-inflammatory cytokines against transforming growth factor-beta-driven SMAD3/4-specific gene expression. (PubMed id 12426318)9 Verrecchia F....Mauviel A. (J. Biol. Chem. 2003)
    1115. Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways. (PubMed id 12853969)9 Park J.I....Chi S.G. (Oncogene 2003)
    1116. Requirement of c-jun for testosterone-induced sensitization to N-(4-hydroxyphenyl)retinamide-induced apoptosis. (PubMed id 12619033)9 Shimada K....Konishi N. (Mol. Carcinog. 2003)
    1117. Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways. (PubMed id 12456688)9 Witowsky J.A. and Johnson G.L. (J. Biol. Chem. 2003)
    1118. Pro-apoptotic tumor necrosis factor-alpha transduction pathway in normal prostate, benign prostatic hyperplasia and prostatic carcinoma. (PubMed id 12913698)9 Ricote M....Fraile B. (J. Urol. 2003)
    1119. C-jun N-terminal kinase (JNK) inhibitor, SP600125, blocks interleukin (IL)-6-induced vascular endothelial growth factor (VEGF) production: cyclosporine A partially mimics this inhibitory effect. (PubMed id 14627919)9 Naruishi K....Takashiba S. (Transplantation 2003)
    1120. Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation. (PubMed id 12372597)9 Hwang I.S....Kim E. (FEBS Lett. 2002)
    1121. 4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells. (PubMed id 12361807)9 Dickinson D.A....Forman H.J. (amp 2002)
    1122. Mitogen-activated protein kinases and activator protein 1 are required for proliferation and cardiomyocyte differentiation of P19 embryonal carcinoma cells. (PubMed id 11884386)9 Eriksson M. and LeppAo S. (J. Biol. Chem. 2002)
    1123. Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells. (PubMed id 12181446)9 Levresse V....Heasley L.E. (Mol. Pharmacol. 2002)
    1124. Green tea polyphenol blocks h(2)o(2)-induced interleukin-8 production from human alveolar epithelial cells. (PubMed id 12161102)9 Matsuoka K....Wada H. (Cytokine 2002)
    1125. Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage. (PubMed id 12091388)9 Ghahremani M.H....Park D.S. (J. Biol. Chem. 2002)
    1126. Transcriptional induction of mitogen-activated protein kinase phosphatase 1 by retinoids. Selective roles of nuclear receptors and contribution to the antiapoptotic effect. (PubMed id 12186877)9 Xu Q....Kitamura M. (J. Biol. Chem. 2002)
    1127. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. (PubMed id 11927626)9 Conze D....RincA^n M. (J. Exp. Med. 2002)
    1128. Protein phosphatase 4 is involved in tumor necrosis factor-alpha- induced activation of c-Jun N-terminal kinase. (PubMed id 11698396)9 Zhou G.... Tan T.H. (J. Biol. Chem. 2002)
    1129. Increased expression of phosphorylated c-Jun amino-terminal kinase and phosphorylated c-Jun in human cerebral aneurysms: role of the c-Jun amino-terminal kinase/c-Jun pathway in apoptosis of vascular walls. (PubMed id 12234410)9 Takagi Y....Hashimoto N. (Neurosurgery 2002)
    1130. Expression of mitogen-activated protein kinases in human renal dysplasia. (PubMed id 11849444)9 Omori S....Awazu M. (Kidney Int. 2002)
    1131. Complex functions of AP-1 transcription factors in differentiation and survival of PC12 cells. (PubMed id 11390664)9 LeppAo S....Bohmann D. (Mol. Cell. Biol. 2001)
    1132. Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. (PubMed id 11764091)9 Atzori C....Migheli A. (J. Neuropathol. Exp. Neurol. 2001)
    1133. Requirement of c-jun N-terminal kinase for apoptotic cell death induced by farnesyltransferase inhibitor, farnesylamine, in human pancreatic cancer cells. (PubMed id 11594773)9 Mizukami Y....Kohgo Y. (Biochem. Biophys. Res. Commun. 2001)
    1134. Inhibition of PI3-kinase sensitises HL60 human leukaemia cells to both chemotherapeutic drug- and Fas-induced apoptosis by a JNK independent pathway. (PubMed id 11489474)9 O'Gorman D.M....Cotter T.G. (Leuk. Res. 2001)
    1135. Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK. (PubMed id 11237388)9 Xu K. and Thornalley P.J. (Br. J. Cancer 2001)
    1136. Activation of c-Jun amino-terminal kinase is required for retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells. (PubMed id 11513861)9 Wang H....Tamura S. (FEBS Lett. 2001)
    1137. Activation of phosphatidylinositol 3-kinase and Akt by tert-butylhydroquinone is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells. (PubMed id 11306698)9 Kang K.W....Kim S.G. (Mol. Pharmacol. 2001)
    1138. Activation of