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MAPK8 Gene

protein-coding   GIFtS: 76
GCID: GC10P049514

Mitogen-Activated Protein Kinase 8


(Previous symbol: PRKM8)
  See MAPK8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 81 2     JNK2
PRKM81 2 3 5     JNK1A22
JNK12 3 5     JNK21B1/22
SAPK12 3 5     Mitogen-Activated Protein Kinase 8 Isoform JNK1 Alpha12
JUN N-Terminal Kinase1 2     Mitogen-Activated Protein Kinase 8 Isoform JNK1 Beta22
Stress-Activated Protein Kinase 1c2 3     Stress-Activated Protein Kinase 12
JNK-462 3     SAPK1C3
SAPK1c2 3     MAPK 83
C-Jun N-Terminal Kinase 12 3     Stress-Activated Protein Kinase JNK13
MAP Kinase 82 3     EC 2.7.118
EC 2.7.11.243 8     

External Ids:    HGNC: 68811   Entrez Gene: 55992   Ensembl: ENSG000001076437   OMIM: 6011585   UniProtKB: P459833   

Export aliases for MAPK8 gene to outside databases

Previous GC identifers: GC10P048468 GC10P049407 GC10P048954 GC10P049279 GC10P043874


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK8 Gene:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and
targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell
stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for
TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to
be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested
that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively
spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Jun 2013)

GeneCards Summary for MAPK8 Gene:
MAPK8 (mitogen-activated protein kinase 8) is a protein-coding gene. Diseases associated with MAPK8 include frozen shoulder, and restrictive cardiomyopathy. GO annotations related to this gene include protein serine/threonine kinase activity and JUN kinase activity. An important paralog of this gene is MAPK9.

UniProtKB/Swiss-Prot: MK08_HUMAN, P45983
Function: Serine/threonine-protein kinase involved in various processes such as cell proliferation,
differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as
proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal
kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7
phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors,
primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity.
Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4
acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for
replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including
p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation
of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the
antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2
dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule
dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic
activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the
ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the
deacetylase SIRT1, ELK1, or the E3 ligase ITCH
Function: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1,
alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation
between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms

summary for MAPK8 Gene:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK8 gene promoter:
         AP-1   ATF-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPK8 promoter sequence
   Search Chromatin IP Primers for MAPK8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.22   Ensembl cytogenetic band:  10q11.22   HGNC cytogenetic band: 10q11

MAPK8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P049514:  view genomic region     (about GC identifiers)

Start:
49,514,698 bp from pter      End:
49,647,403 bp from pter
Size:
132,706 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MK08_HUMAN, P45983 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 8  
Size: 427 amino acids; 48296 Da
Cofactor: Magnesium
Subunit: Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and
SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53
and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and ARHGEF28 (By similarity). Interacts
(phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells (By similarity).
Interacts with NFATC4. Interacts with MECOM; regulates JNK signaling. Interacts with PIN1; this interaction
mediates MAPK8 conformational changes leading to the binding of MAPK8 to its substrates
Selected PDB 3D structures from and Proteopedia for MAPK8 (see all 27):
1UKH (3D)        1UKI (3D)        2G01 (3D)        2GMX (3D)        2H96 (3D)        2NO3 (3D)    
Secondary accessions: B5BTZ5 B7ZLV4 D3DX88 D3DX92 Q15709 Q15712 Q15713
Alternative splicing: 4 isoforms:  P45983-1   P45983-2   P45983-3   P45983-4   (Contains a phosphoserine at position 377)

Explore the universe of human proteins at neXtProt for MAPK8: NX_P45983

Explore proteomics data for MAPK8 at MOPED

Post-translational modifications: 

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by
    TAOK21
  • Ubiquitination2 at Lys166
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPK8 (P45983) (see all 27)
     KELIYKE  ILDFGLA  LDFGLAR  LLSKMLV 


    See MAPK8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265476.1  NP_001265477.1  NP_002741.1  NP_620634.1  NP_620637.1  

    ENSEMBL proteins: 
     ENSP00000387936   ENSP00000393223   ENSP00000363304   ENSP00000397729   ENSP00000363297  
     ENSP00000363294   ENSP00000363291   ENSP00000363289   ENSP00000353483   ENSP00000378974  
    Reactome Protein details: P45983

    MAPK8 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAPK8 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MAPK8
    OriGene Purified Proteins for MAPK8
    OriGene Protein Over-expression Lysate for MAPK8
    OriGene MassSpec for MAPK8
    OriGene Custom Protein Services for MAPK8
    GenScript Custom Purified and Recombinant Proteins Services for MAPK8
    Novus Biologicals MAPK8 Proteins
    Novus Biologicals MAPK8 Lysates
    Sino Biological Recombinant Protein for MAPK8
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAPK8

     
    Search eBioscience for Proteins for MAPK8 

     
    antibodies-online proteins for MAPK8 (14 products) 

     
    antibodies-online peptides for MAPK8

    MAPK8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK8
    R&D Systems Antibodies for MAPK8 (JNK1)
    Cell Signaling Technology (CST) Antibodies for MAPK8  (JNK1)
    OriGene Antibodies for MAPK8
    OriGene Custom Antibody Services for MAPK8
    Novus Biologicals MAPK8 Antibodies
    Abcam antibodies for MAPK8 (P45983, P53779, P45984)
    Cloud-Clone Corp. Antibodies for MAPK8
    ThermoFisher Antibody for MAPK8
    antibodies-online antibodies for MAPK8 (255 products) 

    MAPK8 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of MAPK8
    OriGene Custom Assay Services for MAPK8
    R&D Systems ELISAs for MAPK8 (JNK1)         (see all)
    GenScript Custom Assay Services for MAPK8
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK8 (JNK1)
    Enzo Life Sciences assays for MAPK8
    Cloud-Clone Corp. ELISAs for MAPK8
    Cloud-Clone Corp. CLIAs for MAPK8
    eBioscience ELISAs for MAPK8: (see all 3
                        phospho-JNK 1/2/3 (Thr183/Tyr185) InstantOne ELISA 96 tests
    antibodies-online kits for MAPK8 (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 8
    JNK subfamily
    Mitogen-activated protein kinases

    Selected InterPro protein domains (see all 6):
     IPR008351 MAPK_JNK
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR003527 MAP_kinase_CS

    Graphical View of Domain Structure for InterPro Entry P45983

    ProtoNet protein and cluster: P45983

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008351 JNK MAP kinase signature


    UniProtKB/Swiss-Prot: MK08_HUMAN, P45983
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAPK8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK08_HUMAN, P45983
    Function: Serine/threonine-protein kinase involved in various processes such as cell proliferation,
    differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as
    proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal
    kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7
    phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors,
    primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity.
    Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4
    acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for
    replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including
    p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation
    of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the
    antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2
    dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule
    dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic
    activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the
    ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the
    deacetylase SIRT1, ELK1, or the E3 ligase ITCH
    Function: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1,
    alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation
    between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases,
    MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183
    preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by SERPINB3

         Genatlas biochemistry entry for MAPK8:
    mitogen-activated protein kinase 8,with three alternatively spliced isoforms JNK1,JNK2,JNK3 (MAP kinase),activated
    by UV irradiation and H-RAS,phosphorylating JUN

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14967141
    GO:0004705JUN kinase activity IDA--
    GO:0004707MAP kinase activity ----
         
    Find genes that share ontologies with MAPK8           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for MAPK8:
     Decreased Hepatitis C virus re  Decreased focal adhesion (FA)   Increased S DNA content  Increased cell death HMECs cel 
     Increased cell death in breast  Increased circadian period len  Increased mitotic index  Increased telomerase activity 
     Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mapk8) (see all 22):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with MAPK8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mapk8tm1Flv for MAPK8

       genOway: Develop your customized and physiologically relevant rodent model for MAPK8

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPK8:
    hsa-mir-125a-5p (MIRT021289), hsa-mir-33a-5p (MIRT028235), hsa-mir-193b-3p (MIRT016510), hsa-mir-421 (MIRT016104), hsa-mir-10a-5p (MIRT025602), hsa-mir-140-3p (MIRT021678), hsa-mir-877-5p (MIRT037323), hsa-mir-214-3p (MIRT005427)

    Block miRNA regulation of human, mouse, rat MAPK8 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MAPK8:
    hsa-miR-3168 hsa-miR-219-2-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAPK8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPK8
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK8

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK8 (see all 23)
    OriGene ORF clones in mouse, rat for MAPK8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK8 (NM_002750)
    Sino Biological Human cDNA Clone for MAPK8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK8
    Addgene plasmids for MAPK8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK8
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK8

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12236) for MAPK8 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MK08_HUMAN, P45983: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular3
    mitochondrion3
    cytoskeleton2
    endoplasmic reticulum2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with MAPK8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK8 About   (see all 181)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TNFR1 Pathway0.56
    Apoptotic Pathways Triggered By HIV10.42
    TNF Signaling0.55
    Apoptosis through Death Receptors0.42
    Apoptosis and survival TNFR1 signaling pathway0.52
    Fas Signaling0.35
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    TWEAK Signaling Pathway0.31
    2Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Development EGFR signaling via PIP30.40
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Development PDGF signaling via MAPK cascades0.41
    Apoptosis and survival Anti apoptotic action of membrane bound ESR10.35
    3NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    4RANK Signaling in Osteoclasts
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANKL/RANK Signaling Pathway0.31
    RANK Signaling in Osteoclasts0.45
    5G protein signaling Ras family GTPases in kinase cascades scheme
    G protein signaling Ras family GTPases in kinase cascades scheme 0.44
    Oncostatin M Signaling Pathway0.37
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Activation of the AP-1 family of transcription factors0.00


    Find genes that share SuperPaths with MAPK8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for MAPK8 (see all 7)
        NOD-like Receptor Signaling Pathways
    Wnt Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK8 (see all 114)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPK8
        MAP Kinase Signaling

    5 Tocris Bioscience Pathways for MAPK8
        Akt Pathway
    Insulin Pathway
    Toll-like Receptor Pathway
    VEGF Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MAPK8 (see all 38)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Development Endothelin-1/EDNRA signaling

    Selected BioSystems Pathways for MAPK8 (see all 77)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Keap1-Nrf2 Pathway
    EBV LMP1 signaling

    4 Sino Biological Pathways for MAPK8
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    Death Receptor Signaling
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for MAPK8 (see all 9)
        NRIF signals cell death from the nucleus
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
    FCERI mediated MAPK activation
    Activation of BIM and translocation to mitochondria
    NRAGE signals death through JNK

    3 PharmGKB Pathways for MAPK8
        EGFR Inhibitor Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for MAPK8) (see all 40):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    FoxO signaling pathway
    Protein processing in endoplasmic reticulum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK8 (see all 23): 
              Antiviral Response in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              Breast Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK8 (P459831, 2, 3 ENSP000003534834) via UniProtKB, MINT, STRING, and/or I2D (see all 295)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054121, 2, 3, ENSP000003602664EBI-286483,EBI-852823 MINT-7148314 I2D: score=11 STRING: ENSP00000360266
    TP53P046372, 3, ENSP000002693054MINT-61312 I2D: score=5 STRING: ENSP00000269305
    BCL2P104152, 3, ENSP000003296234MINT-56639 I2D: score=4 STRING: ENSP00000329623
    BCL2L1Q078172, 3, ENSP000003025644MINT-56640 I2D: score=4 STRING: ENSP00000302564
    CRKP461082, 3, ENSP000003005744MINT-7103547 I2D: score=4 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 42):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with MAPK8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MAPK8
      Browse compounds at ApexBio 

    Compounds for MAPK8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS JNK 6oSelective JNK inhibitor[894804-07-0]
    SP 600125Novel and selective JNK inhibitor[129-56-6]
    TCS JNK 5aSelective inhibitor of JNK2 and JNK3[312917-14-9]
    SU 3327Selective JNK inhibitor[40045-50-9]
    BI 78D3 Selective, competitive JNK inhibitor [883065-90-5]

    3 HMDB Compounds for MAPK8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    6 DrugBank Compounds for MAPK8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One-- --target--10592235
    2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE-- --target--10592235
    2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide-- --target--10592235
    5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE-- --target--10592235
    6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE-- --target--10592235
    N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for MAPK8 gene (see all 130)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp 600125 97.5 1060 15454338 (4), 17322004 (4), 14766793 (3), 15242986 (3) (see all 99)
    sb 203580 92.2 314 18655782 (4), 18222647 (3), 18718914 (2), 9598985 (2) (see all 99)
    pd 98,059 89.3 240 11164710 (2), 16480952 (2), 17191113 (2), 9603971 (1) (see all 99)
    anisomycin 81.1 110 17699104 (6), 8626428 (3), 12220537 (3), 16672691 (2) (see all 63)
    ly294002 74.7 76 10628325 (2), 16722795 (2), 9878764 (2), 12555073 (2) (see all 57)
    kt 7515 74.2 7 9631443 (2), 12376548 (1), 11279271 (1), 11756493 (1) (see all 6)
    n acetylcysteine 74 137 19176594 (3), 8824287 (2), 18038907 (2), 18679584 (2) (see all 84)
    phosphatidylinositol 72.9 135 9315636 (4), 10050043 (3), 16000309 (3), 17008315 (3) (see all 99)
    pd 169316 72.3 14 14724571 (1), 16440327 (1), 11141234 (1), 19605737 (1) (see all 12)
    tyrosine 71 223 12709432 (3), 10085098 (3), 11237388 (3), 18713649 (3) (see all 99)



    Find genes that share compounds with MAPK8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for MAPK8 gene (5 alternative transcripts): 
    NM_001278547.1  NM_001278548.1  NM_002750.3  NM_139046.2  NM_139049.2  

    Unigene Cluster for MAPK8:

    Mitogen-activated protein kinase 8
    Hs.138211  [show with all ESTs]
    Unigene Representative Sequence: AK094000
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432379 ENST00000429041 ENST00000374189(uc001jgn.3 uc001jgp.3 uc001jgq.3 uc009xoa.3)
    ENST00000426557 ENST00000476134 ENST00000374182 ENST00000374179(uc001jgm.3 uc001jgo.3 uc021ppy.1 uc010qgk.2)
    ENST00000374176 ENST00000374174 ENST00000469879 ENST00000471272 ENST00000469110
    ENST00000482840 ENST00000459755 ENST00000360332 ENST00000395611
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate MAPK8:
    hsa-miR-3168 hsa-miR-219-2-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAPK8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAPK8
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    OriGene ORF clones in mouse, rat for MAPK8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK8 (NM_002750)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK8
    Addgene plasmids for MAPK8 
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    OriGene qPCR primer pairs and template standards for MAPK8
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK8
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      QuantiFast Probe-based Assays in human, mouse, rat MAPK8
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12236) for MAPK8 

    Additional mRNA sequence: 

    AB451231.1 AB451271.1 AB451354.1 AB451398.1 AK094000.1 AK292523.1 BC130570.1 BC130572.1 
    BC144063.1 DQ234352.1 L26318.1 U34822.1 U35004.1 U35005.1 

    10 DOTS entries:

    DT.40125643  DT.100746960  DT.121226927  DT.91754467  DT.454686  DT.100732619  DT.100746961  DT.100746962 
    DT.65287263  DT.75198831 

    Selected AceView cDNA sequences (see all 122):

    AK125150 U34822 NM_002750 NM_139047 AA488157 U35005 BX418803 L26318 
    AI379407 AI961756 AA808177 BX117775 U35004 AA452842 NM_139049 CD364702 
    AA452406 CD236761 AW005952 BU183270 CA443441 BF591196 BM771576 BM698011 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e
    SP1:                                            -                 -                                                   
    SP2:                                      -                       -                                                   
    SP3:                                      -                       -                                                   
    SP4:                                            -                 -                                                   
    SP5:                                      -     -     -           -                                                   


    ECgene alternative splicing isoforms for MAPK8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAPK8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAATACAT
    MAPK8 Expression
    About this image


    MAPK8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Neural Tube (Nervous System)
             Rhombencephalon
    MAPK8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.138211
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK8 (see all 23): 
              Antiviral Response in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              Breast Cancer in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MAPK8
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK8
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    QuantiFast Probe-based Assays in human, mouse, rat MAPK8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAPK8 gene from 19 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia MAPK81 mitogen-activated protein kinase 8 99.61(n)
    99.77(a)
      450445  XM_001136927.1  XP_001136927.1 
    mouse
    (Mus musculus)
    Mammalia Mapk81 , 5 mitogen-activated protein kinase 81, 5 91.67(n)1
    97.63(a)1
      14 (20.22 cM)5
    264191  NM_016700.41  NP_057909.11 
     333778985 
    rat
    (Rattus norvegicus)
    Mammalia Mapk81 mitogen-activated protein kinase 8 91.18(n)
    97.42(a)
      116554  NM_053829.1  NP_446281.1 
    cow
    (Bos taurus)
    Mammalia MAPK81 mitogen-activated protein kinase 8 95.7(n)
    99.21(a)
      539941  NM_001192974.1  NP_001179903.1 
    dog
    (Canis familiaris)
    Mammalia MAPK81 mitogen-activated protein kinase 8 96.1(n)
    99.53(a)
      477746  XM_005637467.1  XP_005637524.1 
    oppossum
    (Monodelphis domestica)
    Mammalia mdo-mir-72556
    mdo-mir-7255
    96(a)
    1 ↔ 1
    1(67940467-68040298)
    platypus
    (Ornithorhynchus anatinus)
    Mammalia --
    --
    --
    95(a)
    89(a)
    1 ↔ many
    1 ↔ many
    3(58876408-58901968)
    3(58776315-58801979)
    chicken
    (Gallus gallus)
    Aves MAPK81 mitogen-activated protein kinase 8 89.15(n)
    99.06(a)
      423778  XM_001233168.3  XP_001233169.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK86
    mitogen-activated protein kinase 8
    93(a)
    1 ↔ 1
    GL343297.1(576935-625480)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984992 hypothetical protein LOC398499 80.03(n)    BC061937.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mapk81 mitogen-activated protein kinase 8 80.13(n)
    95.66(a)
      100170194  NM_001129943.1  NP_001123415.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapk82 mitogen-activated protein kinase 8 75.5(n)   65236  AB030900.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.68672 Oncorhynchus mykiss transcribed sequence with moderate more 77.95(n)    BX299065.1 
    sea squirt
    (Ciona intestinalis)
    Ascidiacea Cin.89002 Ciona intestinalis cDNA, clonecilv018o21, full insert more 75.1(n)    AK112797.1 
    sea squirt
    (Ciona savignyi)
    Ascidiacea --
    Uncharacterized protein
    59(a)
    1 → many
    reftig_26(710412-716462)
    fruit fly
    (Drosophila melanogaster)
    Insecta bsk1 , 3 JNK cascade protein serine/threonine
    kinase3
    basket1
    77(a)3
    68.6(n)1
    79.89(a)1
      2 31B33
    448011  NM_001169459.11  NP_001162930.11 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0094611 AgaP_AGAP009461 68.76(n)
    81.74(a)
      1271440  XM_310236.3  XP_310236.3 
    worm
    (Caenorhabditis elegans)
    Secernentea jnk-11 , 3 MAP kinase3
    jnk-11
    70(a)
    (best of 5)3
    64.59(n)1
    71.67(a)1
      IV(6957865-6963780)3
    1774601  NM_001026099.31  NP_001021270.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HOG16
    Mitogen-activated protein kinase involved in osmor...
    34(a)
    1 → many
    XII(371620-372927) YLR113W
            Species with no ortholog for MAPK8

    ENSEMBL Gene Tree for MAPK8 (if available)
    TreeFam Gene Tree for MAPK8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK8 gene
    MAPK92  MAPK122  MAPK132  MAPK112  MAPK142  MAPK102  
    Selected SIMAP similar genes for MAPK8 using alignment to 7 protein entries:     MK08_HUMAN (see all proteins) (see all similar genes):
    MAPK10    MAPK9    STK11    MAPK14    MAPK11    MYO3B
    MAPK13    OXSR1    CDK14    MAPK3    CAMKK2    CDK19
    EIF2AK3    MOK    NLK    CDKL2    MAP2K3    STK38L

    Find genes that share paralogs with MAPK8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPK8 (see all 766)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0422584
    A renal clear cell carcinoma sample4--see VAR_0422582 G S mis40--------
    VAR_0422594
    A glioblastoma multiforme sample4--see VAR_0422592 G R mis40--------
    rs1115404941,2
    C--43901865(+) TTTTTT/-GAGAC 4 -- int11Minor allele frequency- -:0.50CSA 2
    rs30477641,2
    C--49612001(+) tgtgt-/GTG/  
      GTGTGT
    atttt
    8 -- cds11NA 2
    rs1112869211,2
    C,F--49612413(+) CCAGGC/ATGGTC 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs106570701,2
    C--49613149(+) TATAT-/AT    
       
    /ATAT
    CTACA
    4 -- int11NA 2
    rs800191611,2
    C--49621284(+) ATGAA-/TATGAA
            
    CATGG
    4 -- cds10--------
    rs1452826791,2
    C--49630051(+) TATTT-/ATTT  
            
    TTGAG
    4 -- int10--------
    rs111013121,2
    C,F,H--50000386(+) CTTTGG/ATAACA 4 -- us2k117Minor allele frequency- A:0.05NS EA NA 1700
    rs1432842001,2
    --50000391(+) GTAACA/TATATA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPK8 (49514698 - 49647403 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MAPK8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518744CNV Loss19592680
    nsv895365CNV Loss21882294
    nsv825373CNV Loss20364138
    nsv519701CNV Loss19592680
    nsv895372CNV Gain21882294
    nsv895371CNV Gain21882294
    nsv895369CNV Gain21882294
    nsv7203OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK8
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601158    OMIM disorders: --

    3 diseases for MAPK8:    
    About MalaCards
    frozen shoulder    restrictive cardiomyopathy    diastolic heart failure

    5 diseases from the University of Copenhagen DISEASES database for MAPK8:
    Cancer     Vascular disease     Toxic encephalopathy     Parkinson's disease
    Diabetes mellitus

    Find genes that share disorders with MAPK8           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MAPK8 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 74.2 205 14523009 (4), 16085647 (2), 16630028 (2), 17121845 (2) (see all 99)
    tumors 67.9 389 19445931 (6), 10037172 (6), 12734425 (5), 12629045 (4) (see all 99)
    cancer 59.7 103 19766599 (4), 20354187 (3), 18008069 (3), 19445931 (3) (see all 71)
    inflammation 58.4 55 18984670 (2), 18506470 (2), 19717791 (2), 9482836 (1) (see all 47)
    neurodegenerative diseases 47.6 17 14744254 (2), 16794604 (1), 14989595 (1), 12480174 (1) (see all 15)
    leukemia 46.9 33 19468286 (3), 15767555 (2), 12898508 (2), 18031783 (2) (see all 28)
    shock 46.1 95 10082520 (5), 11050083 (4), 11527157 (4), 18036352 (2) (see all 57)
    colon cancer 44.8 28 19352384 (3), 19243468 (2), 17591974 (2), 14722256 (1) (see all 23)
    insulin resistance 43 54 16085647 (2), 19063863 (2), 12554784 (2), 19277946 (2) (see all 35)
    prostate cancer 42.4 65 12902351 (4), 17671214 (4), 12853969 (3), 19010898 (2) (see all 44)

    Genetic Association Database (GAD): MAPK8
    Human Genome Epidemiology (HuGE) Navigator: MAPK8 (9 documents)

    Export disorders for MAPK8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK8 gene, integrated from 10 sources (see all 3596):
    (articles sorted by number of sources associating them with MAPK8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Selective interaction of JNK protein kinase isoforms with transcription factors. (PubMed id 8654373)1, 2, 3, 9 Gupta S.... Davis R.J. (EMBO J. 1996)
    2. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. (PubMed id 8137421)1, 2, 3 Derijard B....Davis R.J. (Cell 1994)
    3. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PubMed id 7839144)1, 2, 9 Derijard B.... Davis R.J. (Science 1995)
    4. A critical step for JNK activation: isomerization by the prolyl isomerase Pin1. (PubMed id 21660049)1, 2 Park J.E.... Cho S. (Cell Death Differ. 2012)
    5. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. (PubMed id 21856198)1, 2 Miotto B. and Struhl K. (Mol. Cell 2011)
    6. Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis. (PubMed id 21148294)1, 2 Wang J.... Zhang J. (Mol. Biol. Cell 2011)
    7. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. (PubMed id 21364637)1, 2 Tomlinson V....Basu S. (Cell Death Dis. 2010)
    10. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5599 HGNC: 6881 AceView: MAPK8 Ensembl:ENSG00000107643 euGenes: HUgn5599
    ECgene: MAPK8 Kegg: 5599 H-InvDB: MAPK8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAPK8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK8 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAPK8 gene:
    Search GeneIP for patents involving MAPK8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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