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Aliases for MAPK8 Gene

Aliases for MAPK8 Gene

  • Mitogen-Activated Protein Kinase 8 2 3 5
  • Stress-Activated Protein Kinase 1c 3 4
  • C-Jun N-Terminal Kinase 1 3 4
  • JUN N-Terminal Kinase 2 3
  • MAP Kinase 8 3 4
  • EC 2.7.11.24 4 63
  • JNK-46 3 4
  • SAPK1c 3 4
  • PRKM8 3 4
  • SAPK1 3 4
  • JNK1 3 4
  • Mitogen-Activated Protein Kinase 8 Isoform JNK1 Alpha1 3
  • Mitogen-Activated Protein Kinase 8 Isoform JNK1 Beta2 3
  • Stress-Activated Protein Kinase JNK1 4
  • Stress-Activated Protein Kinase 1 3
  • JNK21B1/2 3
  • EC 2.7.11 63
  • JNK1A2 3
  • MAPK 8 4
  • JNK 3

External Ids for MAPK8 Gene

Previous HGNC Symbols for MAPK8 Gene

  • PRKM8

Previous GeneCards Identifiers for MAPK8 Gene

  • GC10P048468
  • GC10P049407
  • GC10P048954
  • GC10P049279
  • GC10P049514
  • GC10P043874

Summaries for MAPK8 Gene

Entrez Gene Summary for MAPK8 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

GeneCards Summary for MAPK8 Gene

MAPK8 (Mitogen-Activated Protein Kinase 8) is a Protein Coding gene. Diseases associated with MAPK8 include fatty liver disease and bile duct carcinoma. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK11.

UniProtKB/Swiss-Prot for MAPK8 Gene

  • Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).

  • JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Tocris Summary for MAPK8 Gene

  • JNKs (c-Jun N-terminal kinases) are a group of mitogen-activated protein kinases (MAPKs), originally called stress activated protein kinases (SAPKs), because they are activated by various environmental stresses. They can also be activated by cytokines and growth factors.

Gene Wiki entry for MAPK8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK8 Gene

Genomics for MAPK8 Gene

Regulatory Elements for MAPK8 Gene

Promoters for MAPK8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAPK8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MAPK8 gene promoter:

Genomic Location for MAPK8 Gene

Chromosome:
10
Start:
48,306,639 bp from pter
End:
48,439,360 bp from pter
Size:
132,722 bases
Orientation:
Plus strand

Genomic View for MAPK8 Gene

Genes around MAPK8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK8 Gene

Proteins for MAPK8 Gene

  • Protein details for MAPK8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45983-MK08_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 8
    Protein Accession:
    P45983
    Secondary Accessions:
    • B5BTZ5
    • B7ZLV4
    • D3DX88
    • D3DX92
    • Q15709
    • Q15712
    • Q15713
    • Q308M2

    Protein attributes for MAPK8 Gene

    Size:
    427 amino acids
    Molecular mass:
    48296 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and ARHGEF28 (By similarity). Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells (By similarity). Interacts with NFATC4. Interacts with MECOM; regulates JNK signaling. Interacts with PIN1; this interaction mediates MAPK8 conformational changes leading to the binding of MAPK8 to its substrates.

    Three dimensional structures from OCA and Proteopedia for MAPK8 Gene

    Alternative splice isoforms for MAPK8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK8 Gene

Proteomics data for MAPK8 Gene at MOPED

Post-translational modifications for MAPK8 Gene

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by TAOK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MAPK8 Gene

Graphical View of Domain Structure for InterPro Entry

P45983

UniProtKB/Swiss-Prot:

MK08_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK8: view

Function for MAPK8 Gene

Molecular function for MAPK8 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase 8,with three alternatively spliced isoforms JNK1,JNK2,JNK3 (MAP kinase),activated by UV irradiation and H-RAS,phosphorylating JUN
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by SERPINB3.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).
UniProtKB/Swiss-Prot Function:
JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Enzyme Numbers (IUBMB) for MAPK8 Gene

Gene Ontology (GO) - Molecular Function for MAPK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035033 histone deacetylase regulator activity IMP 20027304
genes like me logo Genes that share ontologies with MAPK8: view

Phenotypes for MAPK8 Gene

GenomeRNAi human phenotypes for MAPK8:
MGI mutant phenotypes for MAPK8:
inferred from 5 alleles
genes like me logo Genes that share phenotypes with MAPK8: view

Animal Models for MAPK8 Gene

MGI Knock Outs for MAPK8:

Animal Model Products

CRISPR Products

miRNA for MAPK8 Gene

miRTarBase miRNAs that target MAPK8

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK8 Gene

Localization for MAPK8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK8 Gene COMPARTMENTS Subcellular localization image for MAPK8 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 4
mitochondrion 4
endoplasmic reticulum 3
extracellular 3
plasma membrane 3
lysosome 2
vacuole 2
endosome 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MAPK8 Gene

Pathways & Interactions for MAPK8 Gene

SuperPathways for MAPK8 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 IL-2 Pathway
3 TWEAK Pathway
4 Toll-Like receptor Signaling Pathways
5 4-1BB Pathway
genes like me logo Genes that share pathways with MAPK8: view

Pathways by source for MAPK8 Gene

Gene Ontology (GO) - Biological Process for MAPK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006281 DNA repair TAS --
GO:0006302 double-strand break repair TAS --
genes like me logo Genes that share ontologies with MAPK8: view

Drugs & Compounds for MAPK8 Gene

(66) Drugs for MAPK8 Gene - From: HMDB, Novoseek, ApexBio, DrugBank, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
anisomycin Experimental Pharma JNK, SAPK and p38 activator 0
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE Experimental Pharma Target 0
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One Experimental Pharma Target 0
2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide Experimental Pharma Target 0

(83) Additional Compounds for MAPK8 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
AEG 3482
63735-71-7
c-JUN peptide
610273-01-3
JIP-1 (153-163)
438567-88-5
genes like me logo Genes that share compounds with MAPK8: view

Drug Products

Transcripts for MAPK8 Gene

Unigene Clusters for MAPK8 Gene

Mitogen-activated protein kinase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - - -
SP6:

Relevant External Links for MAPK8 Gene

GeneLoc Exon Structure for
MAPK8
ECgene alternative splicing isoforms for
MAPK8

Expression for MAPK8 Gene

mRNA expression in normal human tissues for MAPK8 Gene

Protein differential expression in normal tissues from HIPED for MAPK8 Gene

This gene is overexpressed in Lung (47.9) and Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK8 Gene



SOURCE GeneReport for Unigene cluster for MAPK8 Gene Hs.138211

genes like me logo Genes that share expression patterns with MAPK8: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MAPK8 Gene

Orthologs for MAPK8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPK8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK8 36
  • 100 (a)
OneToOne
MAPK8 35
  • 99.61 (n)
  • 99.77 (a)
cow
(Bos Taurus)
Mammalia MAPK8 36
  • 96 (a)
OneToOne
MAPK8 35
  • 95.7 (n)
  • 99.21 (a)
dog
(Canis familiaris)
Mammalia MAPK8 35
  • 96.1 (n)
  • 99.53 (a)
MAPK8 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk8 16
Mapk8 36
  • 99 (a)
OneToOne
Mapk8 35
  • 91.67 (n)
  • 97.63 (a)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-7255 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mapk8 35
  • 91.18 (n)
  • 97.42 (a)
chicken
(Gallus gallus)
Aves MAPK8 36
  • 97 (a)
OneToOne
MAPK8 35
  • 89.15 (n)
  • 99.06 (a)
lizard
(Anolis carolinensis)
Reptilia MAPK8 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398499 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk8 35
  • 80.13 (n)
  • 95.66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6867 35
zebrafish
(Danio rerio)
Actinopterygii mapk8 35
mapk8a 35
  • 76.89 (n)
  • 87.35 (a)
mapk8a 36
  • 88 (a)
OneToMany
mapk8b 36
  • 84 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009461 35
  • 68.76 (n)
  • 81.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta bsk 37
  • 77 (a)
bsk 36
  • 76 (a)
OneToMany
bsk 35
  • 68.6 (n)
  • 79.89 (a)
worm
(Caenorhabditis elegans)
Secernentea jnk-1 36
  • 55 (a)
OneToMany
jnk-1 35
  • 64.59 (n)
  • 71.67 (a)
C49C3.10a 37
  • 32 (a)
C49C3.10b 37
  • 33 (a)
F09C12.2 37
  • 35 (a)
jnk-1 37
  • 70 (a)
Y51B9A.9 37
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOG1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8900 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToMany
Species with no ortholog for MAPK8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK8 Gene

ENSEMBL:
Gene Tree for MAPK8 (if available)
TreeFam:
Gene Tree for MAPK8 (if available)

Paralogs for MAPK8 Gene

Paralogs for MAPK8 Gene

genes like me logo Genes that share paralogs with MAPK8: view

Variants for MAPK8 Gene

Sequence variations from dbSNP and Humsavar for MAPK8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_042258 A renal clear cell carcinoma sample
VAR_042259 A glioblastoma multiforme sample
VAR_050592 -
rs452561 -- 48,375,087(+) ACATA(C/T)GCAAA intron-variant
rs724124 -- 48,398,486(+) TCACA(C/T)GTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK8 Gene

Variant ID Type Subtype PubMed ID
nsv7203 OTHER Inversion 18451855
nsv895365 CNV Loss 21882294
nsv895369 CNV Gain 21882294
nsv895371 CNV Gain 21882294
nsv895372 CNV Gain 21882294
nsv825373 CNV Loss 20364138
nsv518744 CNV Loss 19592680
nsv519701 CNV Loss 19592680

Variation tolerance for MAPK8 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK8 Gene

HapMap Linkage Disequilibrium report
MAPK8
Human Gene Mutation Database (HGMD)
MAPK8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK8 Gene

Disorders for MAPK8 Gene

MalaCards: The human disease database

(27) MalaCards diseases for MAPK8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fatty liver disease
  • alcoholic fatty liver
bile duct carcinoma
  • carcinoma of extrahepatic bile duct
breast cancer
  • breast cancer, invasive ductal
hepatitis
  • hepatitis a
cisplatin toxicity
- elite association - COSMIC cancer census association via MalaCards
Search MAPK8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAPK8

Genetic Association Database (GAD)
MAPK8
Human Genome Epidemiology (HuGE) Navigator
MAPK8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK8
genes like me logo Genes that share disorders with MAPK8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK8 Gene

Publications for MAPK8 Gene

  1. Selective interaction of JNK protein kinase isoforms with transcription factors. (PMID: 8654373) Gupta S. … Davis R.J. (EMBO J. 1996) 2 3 4 67
  2. Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: involvement of ERK, JNK, AP-1, and NF-kappaB. (PMID: 20432452) Yang C.M. … Hsiao L.D. (J. Cell. Physiol. 2010) 3 23
  3. [Involvement of JNK and caspase-3 in human lymphoma cell apoptosis induced by Prunella vulgaris]. (PMID: 20450729) Liu X.K. … Zhang M.Z. (Zhonghua Yi Xue Za Zhi 2010) 3 23
  4. Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes. (PMID: 20173753) Manganaro L. … Giacca M. (Nat. Med. 2010) 3 23
  5. Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation. (PMID: 20156194) Nakagawa K. … Nishina H. (Biochem. J. 2010) 3 23

Products for MAPK8 Gene

Sources for MAPK8 Gene

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