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Aliases for MAPK8 Gene

Aliases for MAPK8 Gene

  • Mitogen-Activated Protein Kinase 8 2 3 5
  • Stress-Activated Protein Kinase 1c 3 4
  • C-Jun N-Terminal Kinase 1 3 4
  • JUN N-Terminal Kinase 2 3
  • MAP Kinase 8 3 4
  • EC 2.7.11.24 4 61
  • JNK-46 3 4
  • SAPK1c 3 4
  • PRKM8 3 4
  • SAPK1 3 4
  • JNK1 3 4
  • Mitogen-Activated Protein Kinase 8 Isoform JNK1 Alpha1 3
  • Mitogen-Activated Protein Kinase 8 Isoform JNK1 Beta2 3
  • Stress-Activated Protein Kinase JNK1 4
  • Stress-Activated Protein Kinase 1 3
  • JNK21B1/2 3
  • EC 2.7.11 61
  • JNK1A2 3
  • MAPK 8 4
  • JNK 3

External Ids for MAPK8 Gene

Previous HGNC Symbols for MAPK8 Gene

  • PRKM8

Previous GeneCards Identifiers for MAPK8 Gene

  • GC10P048468
  • GC10P049407
  • GC10P048954
  • GC10P049279
  • GC10P049514
  • GC10P043874

Summaries for MAPK8 Gene

Entrez Gene Summary for MAPK8 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

GeneCards Summary for MAPK8 Gene

MAPK8 (Mitogen-Activated Protein Kinase 8) is a Protein Coding gene. Diseases associated with MAPK8 include Fatty Liver Disease and Renal Fibrosis. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CCR5 Pathway in Macrophages. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK10.

UniProtKB/Swiss-Prot for MAPK8 Gene

  • Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973).

  • JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Tocris Summary for MAPK8 Gene

  • JNKs (c-Jun N-terminal kinases) are a group of mitogen-activated protein kinases (MAPKs), originally called stress activated protein kinases (SAPKs), because they are activated by various environmental stresses. They can also be activated by cytokines and growth factors.

Gene Wiki entry for MAPK8 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK8 Gene

Genomics for MAPK8 Gene

Regulatory Elements for MAPK8 Gene

Enhancers for MAPK8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G048431 0.8 dbSUPER 16.8 +125.6 125644 1.4 BRD4 LEF1 CBX3 ARNT NFRKB TAL1 TCF12 FOXM1 GATA2 NCOR1 MAPK8 ENSG00000279822
GH10G048363 1.1 Ensembl ENCODE 10.7 +57.2 57249 0.7 HDAC1 HDGF CBX3 TBL1XR1 ARNT RAD21 CHAMP1 ZNF143 FOS CREM ARHGAP22 MAPK8 ENSG00000279822
GH10G048364 1 Ensembl ENCODE 10.7 +58.6 58568 1.5 FEZF1 ZNF843 GABPA ZNF101 NFIC JUND PRDM6 POLR2A GATA2 SMARCA4 ARHGAP22 MAPK8 ENSG00000279822
GH10G048399 1.2 Ensembl ENCODE 7.8 +93.2 93186 1.6 PKNOX1 ARID4B SIN3A ZNF48 SLC30A9 GLIS2 ZNF766 GATA2 ELK1 ZNF143 MAPK8 ENSG00000279822
GH10G048199 0.8 Ensembl 11.3 -106.8 -106813 0.5 PKNOX1 RB1 ZFP64 ZBTB40 ZNF2 RAD21 ZNF366 ZNF143 DEK ZNF263 MAPK8 BMS1P7 PTPN20CP FRMPD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAPK8 on UCSC Golden Path with GeneCards custom track

Promoters for MAPK8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000027749 461 1801 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 KLF13

Transcription factor binding sites by QIAGEN in the MAPK8 gene promoter:

Genomic Location for MAPK8 Gene

Chromosome:
10
Start:
48,306,639 bp from pter
End:
48,439,360 bp from pter
Size:
132,722 bases
Orientation:
Plus strand

Genomic View for MAPK8 Gene

Genes around MAPK8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK8 Gene

Proteins for MAPK8 Gene

  • Protein details for MAPK8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45983-MK08_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 8
    Protein Accession:
    P45983
    Secondary Accessions:
    • B5BTZ5
    • B7ZLV4
    • D3DX88
    • D3DX92
    • Q15709
    • Q15712
    • Q15713
    • Q308M2

    Protein attributes for MAPK8 Gene

    Size:
    427 amino acids
    Molecular mass:
    48296 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and ARHGEF28 (By similarity). Interacts with HSF1 (via D domain and preferentially with hyperphosphorylated form); this interaction occurs under both normal growth conditions and immediately upon heat shock (PubMed:10747973). Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells (By similarity). Interacts with NFATC4. Interacts with MECOM; regulates JNK signaling. Interacts with PIN1; this interaction mediates MAPK8 conformational changes leading to the binding of MAPK8 to its substrates.

    Three dimensional structures from OCA and Proteopedia for MAPK8 Gene

    Alternative splice isoforms for MAPK8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK8 Gene

Selected DME Specific Peptides for MAPK8 Gene

P45983:
  • PIGSGAQGIVC
  • YVENRPKY
  • MTPYVVTRYYRAPEVI
  • IDQWNKV
  • DKQLDEREH
  • VNHKNII
  • KELIYKE
  • ILDFGLA
  • HSAGIIHRDLKPSN
  • LLNVFTPQK
  • KKLSRPFQ
  • LLSKMLVID
  • EFMKKLQPTVR
  • AKRAYRE
  • DSTFTVLKRYQ
  • LEEFQDVY
  • RDLLSKML
  • LLSKMLV
  • QARDLLS
  • VGCIMGE
  • SYLLYQMLCG
  • LDFGLAR
  • RISVDEAL
  • VMELMDANLC
  • YINVWYD
  • KNGVIRGQP
  • LKILDFGLAR

Post-translational modifications for MAPK8 Gene

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by TAOK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MAPK8 Gene

Graphical View of Domain Structure for InterPro Entry

P45983

UniProtKB/Swiss-Prot:

MK08_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK8: view

Function for MAPK8 Gene

Molecular function for MAPK8 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase 8,with three alternatively spliced isoforms JNK1,JNK2,JNK3 (MAP kinase),activated by UV irradiation and H-RAS,phosphorylating JUN
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by SERPINB3.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973).
UniProtKB/Swiss-Prot Function:
JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Enzyme Numbers (IUBMB) for MAPK8 Gene

Gene Ontology (GO) - Molecular Function for MAPK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 14967141
GO:0004705 JUN kinase activity TAS --
GO:0004707 MAP kinase activity IEA --
genes like me logo Genes that share ontologies with MAPK8: view

Phenotypes for MAPK8 Gene

MGI mutant phenotypes for MAPK8:
inferred from 5 alleles
GenomeRNAi human phenotypes for MAPK8:
genes like me logo Genes that share phenotypes with MAPK8: view

Animal Models for MAPK8 Gene

MGI Knock Outs for MAPK8:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPK8

CRISPR Products

miRNA for MAPK8 Gene

miRTarBase miRNAs that target MAPK8

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK8 Gene

Localization for MAPK8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK8 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
plasma membrane 3
extracellular 3
cytoskeleton 3
endoplasmic reticulum 3
peroxisome 2
lysosome 2
endosome 1

Gene Ontology (GO) - Cellular Components for MAPK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 20027304
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MAPK8: view

Pathways & Interactions for MAPK8 Gene

SuperPathways for MAPK8 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 IL-2 Pathway
3 TNFR1 Pathway
4 Toll-Like receptor Signaling Pathways
5 4-1BB Pathway
genes like me logo Genes that share pathways with MAPK8: view

Pathways by source for MAPK8 Gene

Gene Ontology (GO) - Biological Process for MAPK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IMP 22441692
GO:0006950 response to stress TAS 8137421
GO:0007254 JNK cascade TAS --
GO:0007258 JUN phosphorylation IDA 14967141
GO:0009411 response to UV IDA 14967141
genes like me logo Genes that share ontologies with MAPK8: view

Drugs & Compounds for MAPK8 Gene

(96) Drugs for MAPK8 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Anisomycin Experimental Pharma JNK agonist, potent and specific 0
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE Experimental Pharma Target 0
2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One Experimental Pharma Target 0
2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide Experimental Pharma Target 0

(68) Additional Compounds for MAPK8 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(5) Tocris Compounds for MAPK8 Gene

Compound Action Cas Number
BI 78D3 Selective, competitive JNK inhibitor 883065-90-5
CEP 1347 Inhibitor of JNK signaling 156177-65-0
SP 600125 Selective JNK inhibitor 129-56-6
SR 3576 Highly potent and selective JNK3 inhibitor 1164153-22-3
TCS JNK 6o Selective JNK inhibitor 894804-07-0

(22) ApexBio Compounds for MAPK8 Gene

Compound Action Cas Number
AEG 3482 inhibitor of Jun kinase (JNK)-dependent apoptosis 63735-71-7
Anisomycin JNK agonist, potent and specific 22862-76-6
AS 602801 Jun Kinase Inhibitor 848344-36-5
AS601245 c-Jun NH2-terminal protein kinase inhibitor 345987-15-7
BI 78D3 Competitive JNK inhibitor 883065-90-5
CC-401 JNK inhibitor,ATP-competitive 395104-30-0
CC-401 hydrochloride JNK inhibitor 1438391-30-0
CC-930 JNK inhibitor,potent and selective 899805-25-5
CEP 1347 JNK inhibitor 156177-65-0
c-JUN peptide 610273-01-3
DB07268 JNK1 inhibitor 929007-72-7
DTP3 inhibitor of GADD45β/MKK7 complex
IQ 3 312538-03-7
JIP-1 (153-163) 438567-88-5
JNK-IN-7 Selective JNK inhibitor 1408064-71-0
JNK-IN-8 JNK inhibitor, selective and irreversible 1410880-22-6
PF-03394197(Oclacitinib) Novel Janus kinase inhibitor 1208319-26-9
Piperine MAPK inhibitor 94-62-2
SP 600125 JNK1/2/3 inhibitor 129-56-6
SU 3327 40045-50-9
TCS JNK 6o JNK inhibitor 894804-07-0
YS-49 JNK/ROS inhibitor 132836-42-1
genes like me logo Genes that share compounds with MAPK8: view

Drug Products

Transcripts for MAPK8 Gene

Unigene Clusters for MAPK8 Gene

Mitogen-activated protein kinase 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - - -
SP6:

Relevant External Links for MAPK8 Gene

GeneLoc Exon Structure for
MAPK8
ECgene alternative splicing isoforms for
MAPK8

Expression for MAPK8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPK8 Gene

Protein differential expression in normal tissues from HIPED for MAPK8 Gene

This gene is overexpressed in Lung (47.9) and Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPK8 Gene



NURSA nuclear receptor signaling pathways regulating expression of MAPK8 Gene:

MAPK8

SOURCE GeneReport for Unigene cluster for MAPK8 Gene:

Hs.138211

Evidence on tissue expression from TISSUES for MAPK8 Gene

  • Nervous system(4.8)
  • Liver(3.3)
  • Blood(3.2)
  • Heart(3.2)
  • Lung(3.2)
  • Muscle(3.2)
  • Intestine(3.1)
  • Kidney(3)
  • Skin(2.9)
  • Pancreas(2.7)
  • Adrenal gland(2.6)
  • Bone marrow(2.6)
  • Spleen(2.6)
  • Eye(2.5)
  • Lymph node(2.5)
  • Stomach(2.4)
  • Bone(2.3)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with MAPK8: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK8 Gene

Orthologs for MAPK8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPK8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK8 35 34
  • 99.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK8 35 34
  • 96.1 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-7255 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK8 35 34
  • 95.7 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mapk8 35 16 34
  • 91.67 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk8 34
  • 91.18 (n)
chicken
(Gallus gallus)
Aves MAPK8 35 34
  • 89.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK8 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk8 34
  • 80.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398499 34
zebrafish
(Danio rerio)
Actinopterygii mapk8b 35
  • 84 (a)
OneToMany
mapk8a 35 34
  • 76.89 (n)
OneToMany
mapk8 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6867 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009461 34
  • 68.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta bsk 36 34 35
  • 68.6 (n)
worm
(Caenorhabditis elegans)
Secernentea jnk-1 36 34 35
  • 64.59 (n)
F09C12.2 36
  • 35 (a)
C49C3.10b 36
  • 33 (a)
Y51B9A.9 36
  • 33 (a)
C49C3.10a 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOG1 35
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 59 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8900 34
Species where no ortholog for MAPK8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK8 Gene

ENSEMBL:
Gene Tree for MAPK8 (if available)
TreeFam:
Gene Tree for MAPK8 (if available)

Paralogs for MAPK8 Gene

Paralogs for MAPK8 Gene

genes like me logo Genes that share paralogs with MAPK8: view

Variants for MAPK8 Gene

Sequence variations from dbSNP and Humsavar for MAPK8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_042258 A renal clear cell carcinoma sample
VAR_042259 A glioblastoma multiforme sample
rs1000001859 -- 48,348,954(+) GCAAA(A/G)AAAAA intron-variant
rs1000005083 -- 48,399,675(+) AGAAA(C/T)TCTGA intron-variant, upstream-variant-2KB
rs1000010300 -- 48,436,574(+) TGTGA(A/C)CAACA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAPK8 Gene

Variant ID Type Subtype PubMed ID
esv2666099 CNV deletion 23128226
esv3623153 CNV loss 21293372
esv3623154 CNV loss 21293372
nsv1039508 CNV gain 25217958
nsv1042677 CNV loss 25217958
nsv467190 CNV gain 19166990
nsv518744 CNV loss 19592680
nsv519701 CNV loss 19592680
nsv550811 CNV gain 21841781
nsv550812 CNV gain 21841781
nsv6587 CNV deletion 18451855
nsv825373 CNV loss 20364138

Variation tolerance for MAPK8 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK8 Gene

Human Gene Mutation Database (HGMD)
MAPK8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK8 Gene

Disorders for MAPK8 Gene

MalaCards: The human disease database

(23) MalaCards diseases for MAPK8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fatty liver disease
  • alcoholic fatty liver
renal fibrosis
small intestine neuroendocrine neoplasm
  • small intestine neuroendocrine tumor
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
hepatitis
  • hepatitis a
- elite association - COSMIC cancer census association via MalaCards
Search MAPK8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAPK8

Genetic Association Database (GAD)
MAPK8
Human Genome Epidemiology (HuGE) Navigator
MAPK8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK8
genes like me logo Genes that share disorders with MAPK8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK8 Gene

Publications for MAPK8 Gene

  1. Selective interaction of JNK protein kinase isoforms with transcription factors. (PMID: 8654373) Gupta S. … Davis R.J. (EMBO J. 1996) 2 3 4 64
  2. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. (PMID: 8137421) Derijard B. … Davis R.J. (Cell 1994) 2 3 4 64
  3. A critical step for JNK activation: isomerization by the prolyl isomerase Pin1. (PMID: 21660049) Park J.E. … Cho S. (Cell Death Differ. 2012) 3 4 64
  4. JNK regulates the photic response of the mammalian circadian clock. (PMID: 22441692) Yoshitane H. … Fukada Y. (EMBO Rep. 2012) 3 4 64
  5. Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells. (PMID: 21095239) Deng H. … Lin A. (Int. J. Biochem. Cell Biol. 2011) 3 4 64

Products for MAPK8 Gene

  • Addgene plasmids for MAPK8

Sources for MAPK8 Gene

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