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Aliases for MAPK8 Gene

Aliases for MAPK8 Gene

  • Mitogen-Activated Protein Kinase 8 2 3
  • PRKM8 3 4 6
  • SAPK1 3 4 6
  • JNK1 3 4 6
  • Stress-Activated Protein Kinase 1c 3 4
  • C-Jun N-Terminal Kinase 1 3 4
  • JUN N-Terminal Kinase 2 3
  • MAP Kinase 8 3 4
  • EC 2.7.11.24 4 63
  • JNK-46 3 4
  • SAPK1c 3 4
  • Mitogen-Activated Protein Kinase 8 Isoform JNK1 Alpha1 3
  • Mitogen-Activated Protein Kinase 8 Isoform JNK1 Beta2 3
  • Stress-Activated Protein Kinase JNK1 4
  • Stress-Activated Protein Kinase 1 3
  • JNK21B1/2 3
  • EC 2.7.11 63
  • JNK1A2 3
  • MAPK 8 4
  • JNK 3

External Ids for MAPK8 Gene

Previous Symbols for MAPK8 Gene

  • PRKM8

Summaries for MAPK8 Gene

Entrez Gene Summary for MAPK8 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]

GeneCards Summary for MAPK8 Gene

MAPK8 (Mitogen-Activated Protein Kinase 8) is a Protein Coding gene. Diseases associated with MAPK8 include frozen shoulder and cisplatin toxicity. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and JUN kinase activity. An important paralog of this gene is MAPK11.

UniProtKB/Swiss-Prot for MAPK8 Gene

  • Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).

  • JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms

Tocris Summary for MAPK8 Gene

  • MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases (ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7), ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and 2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38 MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and inflammation (p38).

Gene Wiki entry for MAPK8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK8 Gene

Genomics for MAPK8 Gene

Genomic Location for MAPK8 Gene

Start:
48,306,639 bp from pter
End:
48,439,360 bp from pter
Size:
132,722 bases
Orientation:
Plus strand

Genomic View for MAPK8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPK8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK8 Gene

Regulatory Elements for MAPK8 Gene

Transcription factor binding sites by QIAGEN in the MAPK8 gene promoter:

Proteins for MAPK8 Gene

  • Protein details for MAPK8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45983-MK08_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 8
    Protein Accession:
    P45983
    Secondary Accessions:
    • B5BTZ5
    • B7ZLV4
    • D3DX88
    • D3DX92
    • Q15709
    • Q15712
    • Q15713
    • Q308M2

    Protein attributes for MAPK8 Gene

    Size:
    427 amino acids
    Molecular mass:
    48296 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP. Forms a complex with MAPK8IP1 and ARHGEF28 (By similarity). Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells (By similarity). Interacts with NFATC4. Interacts with MECOM; regulates JNK signaling. Interacts with PIN1; this interaction mediates MAPK8 conformational changes leading to the binding of MAPK8 to its substrates.

    Three dimensional structures from OCA and Proteopedia for MAPK8 Gene

    Alternative splice isoforms for MAPK8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK8 Gene

Proteomics data for MAPK8 Gene at MOPED

Post-translational modifications for MAPK8 Gene

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by TAOK2.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys166

Domains for MAPK8 Gene

Gene Families for MAPK8 Gene

Graphical View of Domain Structure for InterPro Entry

P45983

UniProtKB/Swiss-Prot:

MK08_HUMAN
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases:
    • P45983
  • Contains 1 protein kinase domain.:
    • P45983
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.:
    • P45983
genes like me logo Genes that share domains with MAPK8: view

Function for MAPK8 Gene

Molecular function for MAPK8 Gene

GENATLAS Biochemistry: mitogen-activated protein kinase 8,with three alternatively spliced isoforms JNK1,JNK2,JNK3 (MAP kinase),activated by UV irradiation and H-RAS,phosphorylating JUN
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by SERPINB3.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).
UniProtKB/Swiss-Prot Function: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms

Enzyme Numbers (IUBMB) for MAPK8 Gene

Gene Ontology (GO) - Molecular Function for MAPK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 14967141
GO:0004705 JUN kinase activity IDA 21095239
GO:0004707 MAP kinase activity --
genes like me logo Genes that share ontologies with MAPK8: view
genes like me logo Genes that share phenotypes with MAPK8: view

Animal Models for MAPK8 Gene

MGI Knock Outs for MAPK8:

No data available for Transcription Factor Targeting and HOMER Transcription for MAPK8 Gene

Localization for MAPK8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK8 Gene COMPARTMENTS Subcellular localization image for MAPK8 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MAPK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20027304
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPK8: view

Pathways for MAPK8 Gene

genes like me logo Genes that share pathways with MAPK8: view

Pathways by source for MAPK8 Gene

Gene Ontology (GO) - Biological Process for MAPK8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade --
GO:0001503 ossification IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MAPK8: view

Compounds for MAPK8 Gene

(5) Tocris Compounds for MAPK8 Gene

Compound Action Cas Number
BI 78D3 Selective, competitive JNK inhibitor [883065-90-5]
SP 600125 Novel and selective JNK inhibitor [129-56-6]
SU 3327 Selective JNK inhibitor [40045-50-9]
TCS JNK 5a Selective inhibitor of JNK2 and JNK3 [312917-14-9]
TCS JNK 6o Selective JNK inhibitor [894804-07-0]

(3) HMDB Compounds for MAPK8 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(130) Novoseek inferred chemical compound relationships for MAPK8 Gene

Compound -log(P) Hits PubMed IDs
sp 600125 97.5 187
sb 203580 92.2 113
pd 98,059 89.3 102
anisomycin 81.1 86
ly294002 74.7 61
genes like me logo Genes that share compounds with MAPK8: view

Transcripts for MAPK8 Gene

Unigene Clusters for MAPK8 Gene

Mitogen-activated protein kinase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - - -
SP6:

Relevant External Links for MAPK8 Gene

GeneLoc Exon Structure for
MAPK8
ECgene alternative splicing isoforms for
MAPK8

Expression for MAPK8 Gene

mRNA expression in normal human tissues for MAPK8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK8 Gene

SOURCE GeneReport for Unigene cluster for MAPK8 Gene Hs.138211

genes like me logo Genes that share expressions with MAPK8: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAPK8 Gene

Orthologs for MAPK8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPK8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK8 35
  • 99.61 (n)
  • 99.77 (a)
MAPK8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK8 35
  • 95.7 (n)
  • 99.21 (a)
MAPK8 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK8 35
  • 96.1 (n)
  • 99.53 (a)
MAPK8 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk8 35
  • 91.67 (n)
  • 97.63 (a)
Mapk8 16
Mapk8 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-7255 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mapk8 35
  • 91.18 (n)
  • 97.42 (a)
chicken
(Gallus gallus)
Aves MAPK8 35
  • 89.15 (n)
  • 99.06 (a)
MAPK8 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK8 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398499 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk8 35
  • 80.13 (n)
  • 95.66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6867 35
zebrafish
(Danio rerio)
Actinopterygii mapk8 35
mapk8a 35
  • 76.89 (n)
  • 87.35 (a)
mapk8a 36
  • 88 (a)
OneToMany
mapk8b 36
  • 84 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009461 35
  • 68.76 (n)
  • 81.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta bsk 35
  • 68.6 (n)
  • 79.89 (a)
bsk 36
  • 76 (a)
OneToMany
bsk 37
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea jnk-1 35
  • 64.59 (n)
  • 71.67 (a)
jnk-1 36
  • 55 (a)
OneToMany
Y51B9A.9 37
  • 33 (a)
jnk-1 37
  • 70 (a)
C49C3.10a 37
  • 32 (a)
F09C12.2 37
  • 35 (a)
C49C3.10b 37
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOG1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8900 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToMany
Species with no ortholog for MAPK8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK8 Gene

ENSEMBL:
Gene Tree for MAPK8 (if available)
TreeFam:
Gene Tree for MAPK8 (if available)

Paralogs for MAPK8 Gene

Paralogs for MAPK8 Gene

genes like me logo Genes that share paralogs with MAPK8: view

Variants for MAPK8 Gene

Sequence variations from dbSNP and Humsavar for MAPK8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3110 -- 48,379,908(-) taaaa(C/T)gtgtg intron-variant
rs8428 -- 48,436,373(+) ATCTG(C/T)AGAAT utr-variant-3-prime
rs9284 -- 48,435,527(+) ATAAC(G/T)TGTAG utr-variant-3-prime
rs383674 -- 48,374,989(+) CCTCA(A/G)TAAAA intron-variant
rs452561 -- 48,375,087(+) ACATA(C/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK8 Gene

Variant ID Type Subtype PubMed ID
nsv7203 OTHER Inversion 18451855
nsv895365 CNV Loss 21882294
nsv895369 CNV Gain 21882294
nsv895371 CNV Gain 21882294
nsv895372 CNV Gain 21882294
nsv825373 CNV Loss 20364138
nsv518744 CNV Loss 19592680
nsv519701 CNV Loss 19592680

Relevant External Links for MAPK8 Gene

HapMap Linkage Disequilibrium report
MAPK8
Human Gene Mutation Database (HGMD)
MAPK8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK8 Gene

Disorders for MAPK8 Gene

(93) Novoseek inferred disease relationships for MAPK8 Gene

Disease -log(P) Hits PubMed IDs
necrosis 74.2 108
tumors 67.9 162
cancer 59.7 88
inflammation 58.4 50
neurodegenerative diseases 47.6 16

Relevant External Links for MAPK8

Genetic Association Database (GAD)
MAPK8
Human Genome Epidemiology (HuGE) Navigator
MAPK8
genes like me logo Genes that share disorders with MAPK8: view

No data available for UniProtKB/Swiss-Prot for MAPK8 Gene

Publications for MAPK8 Gene

  1. Selective interaction of JNK protein kinase isoforms with transcription factors. (PMID: 8654373) Gupta S. … Davis R.J. (EMBO J. 1996) 2 3 4
  2. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. (PMID: 8137421) Derijard B. … Davis R.J. (Cell 1994) 2 3 4
  3. Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation. (PMID: 20156194) Nakagawa K. … Nishina H. (Biochem. J. 2010) 3 23
  4. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PMID: 7839144) Derijard B. … Davis R.J. (Science 1995) 3 4
  5. Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: involvement of ERK, JNK, AP-1, and NF-kappaB. (PMID: 20432452) Yang C.M. … Hsiao L.D. (J. Cell. Physiol. 2010) 3 23

Products for MAPK8 Gene

  • Addgene plasmids for MAPK8

Sources for MAPK8 Gene

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