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MAPK8 Gene

protein-coding GIFtS: 71

GC10P049279

mitogen-activated protein kinase 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PRKM8)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.24 ^³
JNK ^¹, ²
JNK-46 ^³
JNK1 ^¹, ², ³, ⁵
JNK1A2 ^²
JNK21B1/2 ^²
OTTHUMP00000019552 ^²
OTTHUMP00000019555 ^²
OTTHUMP00000019556 ^²
OTTHUMP00000019558 ^²
PRKM8 ^², ³, ⁵
SAPK1 ^¹, ², ⁵

Descriptions
JNK1 alpha protein kinase ^²
JNK1 beta protein kinase ^²
JUN N-terminal kinase ^²
Stress-activated protein kinase JNK1 ^², ³
c-Jun N-terminal kinase 1 ^², ³
mitogen-activated protein kinase 8 ^²
mitogen-activated protein kinase 8 isoform JNK1 alpha1 ^²
mitogen-activated protein kinase 8 isoform JNK1 beta2 ^²
protein kinase JNK1 ^²

External Ids
HGNC: 6881¹
Entrez Gene: 5599²
UniProtKB: P45983³
Ensembl: ENSG00000107643⁷

Search outside databases for aliases for MAPK8 gene

Previous GC identifers: GC10P048468 GC10P049407 GC10P048954

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAPK8:

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an

integration point for multiple biochemical signals, and are involved in a wide variety of cellular

processes such as proliferation, differentiation, transcription regulation and development. This

kinase is activated by various cell stimuli, and targets specific transcription factors, and thus

mediates immediate-early gene expression in response to cell stimuli. The activation of this

kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced

apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be

related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene

suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.

Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

[provided by RefSeq]

UniProtKB/Swiss-Prot: MK08_HUMAN, P45983

Function: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun,

whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2.

However, there is no correlation between binding and phosphorylation, which is achieved at about

the same efficiency by all isoforms

Gene Wiki entry for MAPK8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAPK8 gene

Entrez Gene cytogenetic band: 10q11.22 Ensembl cytogenetic band: 10q11.22 HGNC cytogenetic band: 10q11

MAPK8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P049279: (about GC identifiers)

Start:	49,184,739 bp from pter
End:	49,317,409 bp from pter
Size:	132,671 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_017696.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MK08_HUMAN, P45983 (See protein sequence)

Recommended Name: Mitogen-activated protein kinase 8

Size: 427 amino acids; 48296 Da

Cofactor: Magnesium

Subunit: Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2,

MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the

JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP. Forms a complex with

MAPK8IP1 and RGNEF (By similarity). Interacts with NFATC4

PDB structures from and Proteopedia :

1UKH (3D)

1UKI (3D)

2G01 (3D)

2GMX (3D)

2H96 (3D)

2NO3 (3D)

3ELJ (3D)

Secondary accessions: Q15709 Q15712 Q15713

Alternative splicing: 4 isoforms: P45983-1 P45983-2 P45983-3 P45983-4

Post-translational modifications:

Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_002741.1 NP_620634.1 NP_620635.1 NP_620637.1

ENSEMBL proteins:

ENSP00000363289 ENSP00000363294 ENSP00000363297 ENSP00000363304 ENSP00000363291 ENSP00000353483

ENSP00000378974

Human Recombinant Proteins

	Invitrogen human recombinant proteins for MAPK8
	Millipore Purified and/or Recombinant MAPK8 Protein
	Sigma-Aldrich Proteins for MAPK8
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (JNK1, JNKI1, JNK1+JNK2, JNK1+JNK2+JNK3)
	Human Recombinant Proteins from Abnova (MAPK8)

OriGene Purified Recombinant Human Protein: MAPK8

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	EXP	9162092 12591950

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Antibodies for MAPK8:

	Invitrogen Antibodies for MAPK8
	Millipore Mono- and Polyclonal Antibodies for the study of MAPK8
	Sigma-Aldrich Antibody Arrays and Antibodies for MAPK8
	R&D Systems Antibodies for MAPK8 (JNK1)
	Cell Signaling Technology (CST) Antibodies for MAPK8 (JNK)
	Antibodies from Abcam (JNK1, JNKI1, JNK1+JNK2, JNK1+JNK2+JNK3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAPK8)
	Novus Biologicals Antibodies for MAPK8

Assays for MAPK8:

	Invitrogen Assays for MAPK8
	Millipore Kits and Assays for the Analysis of MAPK8
	R&D Systems ELISAs for MAPK8 (JNK1) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK8 (JNK)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P45983

ProtoNet protein and cluster: P45983

2 Blocks protein families:

IPB003527 MAP kinase

IPB008351 JNK MAP kinase signature

UniProtKB/Swiss-Prot: MK08_HUMAN, P45983

Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates

the MAP kinases

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP

kinase subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAPK8)
		Millipore RNAi Products for the Analysis of MAPK8 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (MAPK8)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_139046

Applied Biosystems Silencer® siRNAs for MAPK8

Sigma-Aldrich siRNA and siRNA Panels for MAPK8

Sigma-Aldrich shRNA Panels and shRNA for MAPK8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_002750
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_002750
untagged cDNA clones in CMV expression vector (see all 7): AK094000

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_139047

UniProtKB/Swiss-Prot: MK08_HUMAN, P45983

Function: Responds to activation by environmental stress and pro-inflammatory cytokines by

phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2

and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required

for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates

heat shock factor protein 4 (HSF4)

Function: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun,

whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2.

However, there is no correlation between binding and phosphorylation, which is achieved at about

the same efficiency by all isoforms

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated by threonine and tyrosine phosphorylation by either of two dual

specificity kinases, MAP2K4 and MAP2K7. Inhibited by dual specificity phosphatases, such as DUSP1

Enzyme Number (IUBMB): EC 2.7.11.24

Genatlas biochemistry entry for MAPK8:

mitogen-activated protein kinase 8,with three alternatively spliced isoforms JNK1,JNK2,JNK3 (MAP

kinase),activated by UV irradiation and H-RAS,phosphorylating JUN

15/20 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mapk8) (see all 20 ):

	adipose tissue	cellular	digestive/alimentary	embryogenesis
growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	liver/biliary system	muscle	nervous system	renal/urinary system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IDA	14967141
GO:0004705	JUN kinase activity	IDA	8654373
GO:0004707	MAP kinase activity	IEA	--
GO:0005515	protein binding	IPI	10490659 11238452 15334056

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/73 Sigma-Aldrich "Your Favorite Gene" Pathways for MAPK8 (Your Favorite Gene powered by Ingenuity) (see all 73 )

TGF-&beta
Cholecystokinin/Gastrin-mediated Signaling
MIF Regulation of Innate Immunity
IL-10 Signaling
T Cell Receptor Signaling

GeneDecks MAPK8 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MAPK8

5/408 Interacting proteins for MAPK8 (ENSP00000363291³ P45983^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 408 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATF2	P15336¹	STRING (score=.999) EBI-288687, EBI-1170906
MAP2K4	P45985¹	STRING (score=.999) EBI-286483, EBI-447868
BCL2	P10415²	STRING (score=.999) MINT-56639
BCL2L1	Q07817²	STRING (score=.933) MINT-56640
MAPK8IP1	Q9UQF2²	STRING (score=.999) MINT-6629301

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cell motion	TAS	10912793
GO:0006950	response to stress	TAS	8137421
GO:0007165	signal transduction	TAS	8137421
GO:0007258	JUN phosphorylation	IDA	14967141
GO:0008633	activation of pro-apoptotic gene products	EXP	14764673

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for MAPK8

Sigma-Aldrich Small Molecules for MAPK8:

Inhibitor

Compounds for MAPK8 available from Tocris Bioscience

Compound	Action	CAS number
SP 600125	Novel and selective JNK inhibitor	[129-56-6]
BI 78D3	Selective, competitive JNK inhibitor	[883065-90-5]
Anisomycin	Protein synthesis inhibitor	[22862-76-6]
AEG 3482	Inhibitor of JNK signaling	[63735-71-7]

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10/30 Novoseek chemical compound relationships for MAPK8 gene (see all 30 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sp 600125	97.32	896	15454338 (4), 17322004 (4), 14766793 (3), 15242986 (3) (see all 99)
pd 98,059	89.36	209	11164710 (2), 16480952 (2), 17191113 (2), 9603971 (1) (see all 99)
kt 7515	75.66	7	9631443 (2), 12376548 (1), 11279271 (1), 11756493 (1) (see all 6)
phosphatidylinositol	72.67	119	9315636 (4), 10050043 (3), 16000309 (3), 17008315 (3) (see all 94)
tyrosine	71.68	214	12709432 (3), 10085098 (3), 11237388 (3), 18713649 (3) (see all 99)
wortmannin	69.75	60	12968928 (4), 12439916 (2), 9315636 (2), 10022864 (2) (see all 44)
ceramide	67.42	138	9648862 (6), 15520191 (6), 11354249 (6), 9786905 (4) (see all 64)
tab-1	65.95	7	17205106 (2), 14673155 (1), 16843436 (1), 16382137 (1)
threonine	62.10	46	10506143 (2), 10637231 (1), 15598880 (1), 15805466 (1) (see all 42)
tab-2	60.69	5	16311020 (2), 10882101 (1), 17343912 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAPK8)
		Millipore RNAi Products for the Analysis of MAPK8 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (MAPK8)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_139046

Sigma-Aldrich siRNA and siRNA Panels for MAPK8

Sigma-Aldrich shRNA Panels and shRNA for MAPK8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002750 NM_139046 NM_139047 NM_139049

REFSEQ mRNAs for MAPK8 gene (4 alternative transcripts):

NM_002750.2 NM_139046.1 NM_139047.1 NM_139049.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002750 NM_139046 NM_139047 NM_139049

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_002750
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_002750
                                 untagged cDNA clones in CMV expression vector (see all 7): AK094000

Additional cDNA sequence:

AB451231.1 AB451271.1 AB451354.1 AB451398.1 AK094000.1 AK292523.1 BC130570.1 BC130572.1

BC144063.1 CR614448.1 DQ234352.1 L26318.1 U34822.1 U35004.1 U35005.1

11 DOTS entries:

DT.40125643 DT.100746960 DT.121226927 DT.91754467 DT.454686 DT.75198831 DT.91693170 DT.100732619

DT.100746961 DT.100746962 DT.65287263

24/122 AceView cDNA sequences (see all 122 ):

AK125150 AW005952 L26318 AA452406 U35004 NM_139047 BU183270 AA452842

BU686309 BM698011 BM667180 BF591196 AA808177 AA488157 U34822 U35005

NM_139049 AI379407 NM_139046 CD236761 AA452983 BX418803 CD364702 BX117775

highest scoring ESTs for MAPK8:

L26318 AI052039 AI681315 CF243190 T04992 T07671 T94169 U34822 U35004 U35005

Unigene Cluster for MAPK8:

Mitogen-activated protein kinase 8

Hs.138211 [show with all ESTs]

Unigene Representative Sequence: AK094000

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK8 (see all 6 )

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12a	·	12b	·	12c	·	12d	·	12e
SP1:															-						-
SP2:													-								-
SP3:													-								-
SP4:															-						-
SP5:													-		-		-				-

About this scheme

ECgene alternative splicing isoforms for MAPK8

7 Ensembl transcripts including schematic representations:

ENST00000374174 ENST00000374179 ENST00000374182 ENST00000374189 ENST00000374176 ENST00000360332

ENST00000395611

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAPK8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAPK8

¹ / ² / ³

18 probe-sets matching MAPK8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34006_s_at²^{, 3}	U95-A	1	1.00	1.00	0.54	1.02	L26318	1.00	1.00	1.00	1
49512_at²^{, 3}	U95-B	1	1.00	1.00	0.78	1.29	AI052039	0.80	1.00	0.91	1
2070_i_at²^{, 3}	U95-A	1	1.00	1.00	-0.22	0.53	L26318	1.00	1.00	1.00	1
2071_s_at²^{, 3}	U95-A	1	1.00	1.00	0.66	0.84	L26318	1.00	1.00	1.00	1
47790_at²^{, 3}	U95-B	1	1.00	1.00	0.64	1.45	AI379407	0.60	1.00	0.82	1
49510_at²^{, 3}	U95-B	1	1.00	1.00	0.90	1.17	AI681315	0.80	1.00	0.91	1
56901_at²^{, 3}	U95-C	1	0.94	1.00	0.78	0.72	AI480307	0.60	1.00	0.82	1
84382_at²^{, 3}	U95-E	1	0.44	1.00	0.69	0.56	AA830832	0.60	1.00	0.82	1
229664_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI379407	0.60	1.00	0.82	1
226046_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU152505	0.60	1.00	0.82	1
226048_at²^{, 3}	U133-B	1	1.00	1.00	--	--	N92719	0.60	1.00	0.82	1
210671_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U35004	0.80	1.00	0.91	1
210477_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U34822	0.80	1.00	0.91	1
229664_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226046_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226048_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210671_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210477_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MAPK8 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATAATACAT

SOURCE GeneReport for Unigene cluster: Hs.138211
Expression variation in blood from EXPOLDB for MAPK8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAPK8 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAPK8¹	--	mitogen-activated protein kinase 8	96.1(n) 99.53(a)	477746 XM_850730.1 XP_855823.1
chimpanzee (Pan troglodytes)	MAPK8¹	--	mitogen-activated protein kinase 8	97.42(n) 97.89(a)	450445 XM_507778.2 XP_507778.2
cow (Bos taurus)	MAPK8¹	--	mitogen-activated protein kinase 8	93.75(n) 97.42(a)	539941 XM_864667.2 XP_869760.1
rat (Rattus norvegicus)	Mapk8¹	--	mitogen-activated protein kinase 8	88.95(n) 94.41(a)	116554 XM_341399.3 XP_341400.3
mouse (Mus musculus)	Mapk8^{1, 5}	14⁵	mitogen-activated protein kinase 8^{1, 5}	91.82(n)¹ 97.89(a)¹	26419¹ NM_016700.3¹ NP_057909.1¹ AA426834⁵ AA645429⁵ (see all 26)

About this table Species with no ortholog for MAPK8

ENSEMBL Gene Tree for MAPK8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAPK8 gene

MAPK9² MAPK10²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/204 NCBI SNPs in MAPK8 are shown (see all 204 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 80)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs10857561^1,2	A,C,F,H	49278644(+)	`CCCAGG/AACATG`	4	--	ng5¹		9	NA EU EA WA	612
	rs1062225^1,2	C,F,H	49313232(+)	`TTTCAA/GGTGAT`	4	--	ng3¹ ese³		12	NS EU EA WA NA	666
	rs17698002^1,2	C,F,H	49279184(+)	`ATGCTA/GGTCAA`	4	--	ng5¹		13	NA EU EA WA	1096
	rs12253926^1,2	C,F,H	49279035(+)	`TCTCTC/GTCTCC`	4	--	ng5¹ trp³		8	EU EA NA	544
	rs3730154^1,2	C,F,H	49279584(+)	`CAGTAA/CGTAAA`	4	--	ng5¹		8	EU EA WA	1582
	rs11101312^1,2	C,F,H	49277756(+)	`CTTTGG/ATAACA`	4	--	ng5¹		8	EU EA WA	838
	rs17697978^1,2	C,F,H	49278796(+)	`GGAGGC/TGAGGA`	4	--	ng5¹		9	NA EU EA WA	620
	rs28395807^1,2	C,F	49279408(+)	`ATGTAT/CTAATA`	4	--	ng5¹		2	--	188
	rs28395810^1,2	C,F	49279464(+)	`TTTTAA/GAAAAA`	4	--	ng5¹		2	--	188
	rs28395809^1,2	F	49309280(+)	`AGAGAG/ACCAAG`	4	A/T	mis¹ ese³ trp³		1	--	32

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HapMap Linkage Disequilibrium images for MAPK8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601158

10/93 Novoseek disease relationships for MAPK8 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	73.15	189	14523009 (4), 16085647 (2), 16630028 (2), 17121845 (2) (see all 99)
tumors	66.36	350	10037172 (6), 12734425 (5), 12629045 (4), 18982452 (4) (see all 99)
cancer	56.26	75	18008069 (3), 15256485 (3), 18636174 (3), 17116751 (2) (see all 58)
inflammation	54.84	47	18984670 (2), 18506470 (2), 9482836 (1), 12354421 (1) (see all 40)
shock	46.48	93	10082520 (5), 11050083 (4), 11527157 (4), 18036352 (2) (see all 55)
neurodegenerative diseases	45.98	16	14744254 (2), 16794604 (1), 14989595 (1), 12480174 (1) (see all 14)
leukemia	45.72	26	15767555 (2), 12898508 (2), 18031783 (2), 11489474 (1) (see all 23)
leukemia promyelocytic acute	41.29	2	16972261 (1), 16818652 (1)
colon cancer	41.15	25	19352384 (3), 17591974 (2), 14722256 (1), 15256484 (1) (see all 21)
prostate cancer	40.62	62	12902351 (4), 17671214 (4), 12853969 (3), 19010898 (2) (see all 41)

About this table

Human Genome Epidemiology Navigator: MAPK8 (3 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/2543 PubMed articles for MAPK8 gene (see all 2543 ):

Selective interaction of JNK protein kinase isoforms with transcription factors. (PubMed id 8654373)^{1, 2, 3, 4} Gupta S....Davis R.J. (1996)
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. (PubMed id 8137421)^{2, 3, 4} Derijard B....Davis R.J. (1994)
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PubMed id 7839144)^{1, 3, 4} Derijard B.... Davis R.J. (1995)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. (PubMed id 16581800)^{3, 4} Hu Y. and Mivechi N.F. (2006)
Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. (PubMed id 15693750)^{3, 4} Jagadish N.... Suri A. (2005)
JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis. (PubMed id 12514174)^{3, 4} Chang N.-S.... Ensign A. (2003)
Synergistic activation of stress-activated protein kinase 1/c-Jun N- terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. (PubMed id 11062067)^{3, 4} Fleming Y....Cohen P. (2000)
Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway. (PubMed id 16086581)^{1, 3} Adler V....Pincus M.R. (2005)
Reversing chemoresistance in cisplatin-resistant human ovarian cancer cells: a role of c-Jun NH2-terminal kinase 1. (PubMed id 16105650)^{1, 3} Li F....Ma D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5599	HGNC: 6881	AceView: MAPK8	Ensembl:ENSG00000107643	euGenes: HUgn5599
ECgene: MAPK8	H-InvDB: MAPK8

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for MAPK8	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases

Licensable Technologies for MAPK8
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MAPK8:

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Antibodies & Assays for MAPK8 (JNK)

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MAPK8 Gene

protein-coding GIFtS: 71

Aliases &
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for MAPK8

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAPK8 (Gene Symbol)
EC 2.7.11.24
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
OTTHUMP00000019552
OTTHUMP00000019555
OTTHUMP00000019556
OTTHUMP00000019558
PRKM8
SAPK1
JNK1 alpha protein kinase
JNK1 beta protein kinase
JUN N-terminal kinase
Stress-activated protein kinase JNK1
c-Jun N-terminal kinase 1
mitogen-activated protein kinase 8
mitogen-activated protein kinase 8 isoform JNK1 alpha1
mitogen-activated protein kinase 8 isoform JNK1 beta2
protein kinase JNK1

MAPK8 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor MAPK8

Summariesfor MAPK8

Genomic Locationfor MAPK8

Proteinsfor MAPK8

Protein Domains/Familiesfor MAPK8

Gene Functionfor MAPK8

Pathways & Interactionsfor MAPK8

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Expression for MAPK8

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Medical Newsfor MAPK8

Publicationsfor MAPK8

Search for MAPK8

Genome Databases showing MAPK8

Other Databases showing MAPK8

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Licensable Technologiesfor MAPK8

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAPK8

Summaries
for MAPK8

Genomic Location
for MAPK8

Proteins
for MAPK8

Protein Domains/
Families
for MAPK8

Gene Function
for MAPK8

Pathways & Interactions
for MAPK8

Drugs & Compounds
for MAPK8

Transcripts
for MAPK8

Expression
for MAPK8

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for MAPK8

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for MAPK8

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for MAPK8

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for MAPK8

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for MAPK8

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for MAPK8

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