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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK7 Gene

protein-coding   GIFtS: 71
GCID: GC17P019281

mitogen-activated protein kinase 7


(Previous symbol: PRKM7)
 Explore 28 diseases affiliated with
MAPK7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAPK7    

Aliases
for MAPK7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase 71 2     MAP Kinase 72 3
ERK51 2 3 5     MAPK 72 3
PRKM71 2 3 5     EC 2.7.11.243 8
BMK11 2 3     ERK42
Big MAP Kinase 12 3     BMK1 Kinase2
Extracellular Signal-Regulated Kinase 52 3     Extracellular-Signal-Regulated Kinase 52
BMK-12 3     EC 2.7.118
ERK-52 3     

External Ids:    HGNC: 68801   Entrez Gene: 55982   Ensembl: ENSG000001664847   OMIM: 6025215   UniProtKB: Q131643   

Export aliases for MAPK7 gene to outside databases

Previous GC identifers: GC17P019413 GC17P020752 GC17P019185 GC17P019443 GC17P019221 GC17P018660


Summaries
for MAPK7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPK7:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated
protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor
molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this
kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different
transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have
been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MK07_HUMAN, Q13164
Function: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The
upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and
phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and
MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function
and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with
MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell
cycle progression

summary for MAPK7:
Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate
intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol
esters. They are expressed in all tissues, at varying levels. Upon activation by MEK, ERK1 and 2 translocate
to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as
p90 RSK.

Gene Wiki entry for MAPK7


Genomic Views
for MAPK7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK7 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAPK7 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

MAPK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P019281:  view genomic region     (about GC identifiers)

Start:
 19,281,034 bp from pter      End:
 19,286,857 bp from pter
Size:
 5,824 bases      Orientation:
 plus strand

Proteins
for MAPK7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MK07_HUMAN, Q13164 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 7  
Size: 816 amino acids; 88386 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with MAP2K5. Forms oligomers (By similarity). Interacts with MEF2A, MEF2C and MEF2D; the interaction
phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D (By similarity).
Interacts with SGK1
Subcellular location: Cytoplasm. Nucleus. Note=Translocates to the nucleus upon activation
Sequence caution: Sequence=AAA81381.1; Type=Frameshift; Positions=19, 32; Sequence=BAD92848.1; Type=Erroneous
initiation;
3 PDB 3D structures from and Proteopedia for MAPK7:
4B99 (3D)        4IC7 (3D)        4IC8 (3D)    
Secondary accessions: Q16634 Q59F50 Q6QLU7 Q7L4P4 Q969G1 Q96G51
Alternative splicing: 4 isoforms:  Q13164-1   Q13164-2   Q13164-3   Q13164-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAPK7: NX_Q13164

Post-translational modifications:

  • Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro
    • on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is
    absent1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13164

    • 4/14 DME Specific Peptides for MAPK7 (Q13164) (see all 14)
     LKIGDFG  VIHRDLK  YVATRWYR  NIIAIKDI 

    MAPK7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_002740.2  NP_620601.1  NP_620602.2  NP_620603.2  

    ENSEMBL proteins: 
     ENSP00000299612   ENSP00000378966   ENSP00000462819   ENSP00000412902   ENSP00000378968  
     ENSP00000458146   ENSP00000462804   ENSP00000311005  
    Reactome Protein details: Q13164
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAPK7 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MAPK7
    OriGene Protein Over-expression Lysate (see all 2): MAPK7
    OriGene Custom Protein Services for MAPK7 
    GenScript Custom Purified and Recombinant Proteins Services for MAPK7
    Novus Biologicals MAPK7 Proteins
    Novus Biologicals MAPK7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAPK7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--


    MAPK7 for ontologies           About GeneDecksing



    MAPK7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK7
    R&D Systems Antibodies for MAPK7 (ERK5/BMK1)
    Cell Signaling Technology (CST) Antibodies for MAPK7  (ERK5)
    OriGene Antibodies (see all 12): MAPK7
    OriGene Custom Antibody Services for MAPK7 
    GenScript Custom Superior Antibodies Services for MAPK7
    Novus Biologicals MAPK7 Antibodies
    Abcam antibodies for MAPK7 
    Uscn Antibodies for MAPK7
    ThermoFisher Antibody for MAPK7

    Assay Products for MAPK7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAPK7
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAPK7

    Protein Domains /
    Families
    for MAPK7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPK7 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR003527 MAP_kinase_CS

    Graphical View of Domain Structure for InterPro Entry Q13164

    ProtoNet protein and cluster: Q13164

    1 Blocks protein family: IPB003527 MAP kinase

    UniProtKB/Swiss-Prot: MK07_HUMAN, Q13164
    Domain: The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAPK7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MK07_HUMAN, Q13164
    Function: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The
    upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and
    phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and
    MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function
    and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with
    MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell
    cycle progression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by tyrosine and threonine phosphorylation (By similarity). Activated in response to
    hyperosmolarity, hydrogen peroxide, and epidermal growth factor (EGF)

         Genatlas biochemistry entry for MAPK7:
    mitogen-activated protein kinase 7,extracellular signal regulated kinase 5 with three alternatively spliced
    isoforms,abundantly expressed in heart,placenta,kidney,skeletal muscle,involved in signal transduction,deleted in
    Smith-Magenis syndrome,involved in the transcriptional activation of factors modulating expression of genes required
    for cell proliferation

    Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target MAPK7:
    hsa-mir-143 (MIRT003759)

    OriGene 3'-UTR Clone (see all 4): MAPK7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK7
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK7 (see all 10):
    hsa-miR-429 hsa-miR-4251 hsa-miR-513a-5p hsa-miR-124 hsa-miR-200c hsa-miR-143 hsa-miR-205* hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK7 (see all 4)
    OriGene shRNA RFP: MAPK7
    OriGene siRNA: MAPK7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPK7

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK7 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK7 (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK7 (NM_139032)
    Sino Biological Human cDNA Clone for MAPK7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK7 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAPK7
    Search LifeMap BioReagents cell lines for MAPK7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK7

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004707MAP kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    MAPK7 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for MAPK7:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability with TRAIL  Increased colony dispersion (i 
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for MAPK7: Mapk7tm1Jsca Mapk7tm1.1Jdl Mapk7tm1Kda Mapk7tm1Wnt
         13 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Mapk7):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  homeostasis/metabolism  integument  mortality/aging 
     muscle  nervous system  normal 

    MAPK7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPK7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/58 super-pathways (see all 58) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2ErbB4 Pathway
    8/9 pathways (see all 9)
    		ErbB4 Pathway1.00
    		Thrombopoietin Pathway0.43
    		ErbB Family Pathway0.59
    		VEGF Signaling Pathway0.35
    		Prolactin Signaling0.54
    		HMGB1 Pathway0.32
    		ErbB2-ErbB3 Heterodimers0.47
    		Growth Hormone Signaling0.32
    3ERK/MAPK targets
    		ERK/MAPK targets1.00
    		MAPK targets/ Nuclear events mediated by MAP kinases0.70
    		Nuclear Events (kinase and transcription factor activation)0.88
    		ERKs are inactivated0.57
    4GPCR Pathway
    		GPCR Pathway1.00
    		Breast Cancer Regulation by Stathmin10.58
    		Ras Pathway0.62
    		NFAT in Immune Response0.58
    5Apoptotic Pathways in Synovial Fibroblasts
    		ERK5 Signaling0.61
    		Glioma Invasiveness0.54
    		eIF2 Pathway0.60
    		Rap1 Pathway0.42

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for MAPK7
        Immune response Function of MEF2 in T lymphocytes
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK7 (see all 56)
        14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    eIF2 Pathway
    G12-G13 in Cellular Signaling

    2 Cell Signaling Technology (CST) Pathways for MAPK7
        MAP Kinase Signaling
    Neuroscience

    2 Tocris Bioscience Pathways for MAPK7
        Insulin Pathway
    Toll-like Receptor Pathway

    2 GeneGo (Thomson Reuters) Pathways for MAPK7
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes

    5/12 BioSystems Pathways for MAPK7 (see all 12) 
        MicroRNAs in cardiomyocyte hypertrophy
    EGFR1 Signaling Pathway
    Integrin-mediated cell adhesion
    MAPK signaling pathway
    Focal Adhesion

    5/31        Reactome Pathways for MAPK7 (see all 31)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 7/8 (TLR7/8) Cascade

    1 PharmGKB Pathway for MAPK7
        VEGF Signaling Pathway

    4         Kegg Pathways  (Kegg details for MAPK7):
        MAPK signaling pathway
    Gap junction
    Neurotrophin signaling pathway
    GnRH signaling pathway


    MAPK7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for MAPK7 (Q131641, 2, 3 ENSP000003110054) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PMLP295901, 3, ENSP000002680584EBI-1213983,EBI-870812 I2D: score=1 STRING: ENSP00000268058
    MAP2K5Q131631, 3, ENSP000001786404EBI-1213983,EBI-1965637 I2D: score=4 STRING: ENSP00000178640
    YWHABP319462, 3, ENSP000003001614MINT-8006540 I2D: score=3 STRING: ENSP00000300161
    GJA1P173023, ENSP000002825614I2D: score=3 STRING: ENSP00000282561
    GOLGB1Q147893, ENSP000003418484I2D: score=3 STRING: ENSP00000341848
    About this table

    Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----


    MAPK7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPK7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK7 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK7:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MAPK7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    XMD 8-92Selective ERK5/BMK1 inhibitor[1234480-50-2]

    3 HMDB Compounds for MAPK7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    10/12 Novoseek chemical compound relationships for MAPK7 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,3,4,6-tetrakisphosphate 80.4 3 16293229 (1), 12223481 (1)
    pd-184352 79.5 4 18071319 (1), 11478941 (1), 15381709 (1), 18358237 (1)
    pd 98,059 65.9 16 10473620 (1), 11160424 (1), 12637502 (1), 11782488 (1) (see all 11)
    pip2 53.6 2 8666584 (1), 16878701 (1)
    tyrosine 43.4 7 10473620 (2), 17573825 (1), 9089215 (1), 12755958 (1) (see all 6)
    phosphatidylinositol 35.7 12 17872495 (1), 19951917 (1), 7637540 (1), 2154447 (1) (see all 5)
    phosphoinositide 32.6 1 2154447 (1)
    wortmannin 23.3 2 11237712 (1)
    genistein 18 3 18761399 (1), 11278431 (1), 16758967 (1)
    serine 3.61 1 18322228 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK7 / MK07 

    Transcripts
    for MAPK7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPK7 gene (4 alternative transcripts): 
    NM_002749.3  NM_139032.2  NM_139033.2  NM_139034.2  

    Unigene Cluster for MAPK7:

    Mitogen-activated protein kinase 7
    Hs.150136  [show with all ESTs]
    Unigene Representative Sequence: NM_139033
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299612 ENST00000571657 ENST00000573417 ENST00000395602(uc002gvq.3)
    ENST00000579284 ENST00000443215 ENST00000395604(uc002gvp.3) ENST00000572968
    ENST00000573466 ENST00000482850 ENST00000581260 ENST00000570306 ENST00000486905
    ENST00000572853 ENST00000490660 ENST00000572716 ENST00000308406(uc002gvn.3 uc002gvo.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): MAPK7
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK7
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK7 (see all 10):
    hsa-miR-429 hsa-miR-4251 hsa-miR-513a-5p hsa-miR-124 hsa-miR-200c hsa-miR-143 hsa-miR-205* hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK7 (see all 4)
    OriGene shRNA RFP: MAPK7
    OriGene siRNA: MAPK7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK7
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK7 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK7 (see all 6)
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    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK7 (NM_139032)
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    Additional cDNA sequence: 

    AK295376.1 BC007404.2 BC007992.2 BC009963.2 BC030134.1 U25278.1 U29725.1 U29726.1 

    16 DOTS entries:

    DT.100824041  DT.91754809  DT.95364060  DT.95113377  DT.100770627  DT.100781325  DT.120954292  DT.100781332 
    DT.75185652  DT.100781330  DT.120954354  DT.91754814  DT.120954290  DT.95364050  DT.95364057  DT.99955532 

    24/184 AceView cDNA sequences (see all 184):

    CR604533 BQ707239 NM_139034 AI640451 AI090255 BX106209 BM672233 BE205869 
    BM680070 BC009963 NM_002749 BX396173 AL045025 BX383362 BC030134 BU158168 
    AY534741 U29726 U29725 BU178205 BC007992 BM845337 NM_139033 CD368156 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK7 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                          -     -     -     -     -                 -     -     -     -     -                                                               
    SP2:                                      -     -     -                 -     -     -     -     -                                                               
    SP3:                                      -     -     -                 -     -     -     -     -                                                               
    SP4:                                                  -                 -     -     -     -     -                                                               
    SP5:                                            -     -                 -     -     -                                                                           


    ECgene alternative splicing isoforms for MAPK7

    Expression
    for MAPK7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGGATCGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPK7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See MAPK7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK7

    SOURCE GeneReport for Unigene cluster: Hs.150136

    UniProtKB/Swiss-Prot: MK07_HUMAN, Q13164
    Tissue specificity: Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not
    detectable in liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK7: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat

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    In Situ
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    Orthologs
    for MAPK7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK7 gene from 6/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia MAPK76
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343220.1(1654548-1660932)
    zebrafish
    (Danio rerio)    		 Actinopterygii mapk71 mitogen-activated protein kinase 7 59.95(n)
    60.34(a)    		   541323  NM_001013451.2  NP_001013469.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea F09C12.23 Ser/Thr protein kinase 40(a)   II(5110015-5114112)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes KDX1(YKL161C)4
    SLT21    		 Protein kinase implicated in the Slt2p mitogen-activated more4
    Slt2p1    		 48.06(n)1
    43.94(a)1    		   11(150687-149386)4
    8564251  NP_011895.11  8536964 
     NP_012761.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MPK41 mitogen-activated protein kinase 4 54.49(n)
    54.79(a)    		   828151  NM_116367.2  NP_192046.1 
    rice
    (Oryza sativa)    		 Liliopsida AK111579.12   -- 75.12(n)    AK111579.1 


    ENSEMBL Gene Tree for MAPK7 (if available)
    TreeFam Gene Tree for MAPK7 (if available) 

    Paralogs
    for MAPK7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK7 gene
    MAPK42  MAPK32  NLK2  MAPK152  MAPK62  MAPK12  
    18/61 SIMAP similar genes for MAPK7 using alignment to 5 protein entries:     MK07_HUMAN (see all proteins) (see all similar genes):
    PHKG2    DKFZp686O0215    MAPK14    MAPK4    MAPK1    MAPK3
    MAPK11    DYRK4    CCRK    NDUFA9    MAPK13    TXK
    CDKL3    CDK3    CDK20    CDK7    MAP4K5    PNCK

    MAPK7 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPK7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/150 NCBI SNPs in MAPK7 are shown (see all 150)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1440116941,2
    		--19279094(+) GAAATC/TGGAAC 3 -- int1 us2k10--------
    rs1144986671,2
    		--19279129(+) TAAAAC/TGGTGC 3 -- int1 us2k10--------
    rs770338191,2
    		F,--19279224(+) GAAAAC/TATGTC 3 -- us2k1 int11Minor allele frequency- T:0.08EA 120
    rs1814670341,2
    		--19279302(+) CAAATA/GTTCAT 3 -- int1 us2k10--------
    rs1841137691,2
    		--19279363(+) GGCCAC/TAAAAA 3 -- us2k1 int10--------
    rs124495781,2
    		H--19279464(+) catccA/Ccaata 3 -- int1 us2k1 tfbs34Minor allele frequency- C:0.00NS EA 420
    rs99148611,2
    		C,F,H,--19279471(+) aatacG/Ccaagt 3 -- int1 us2k1 tfbs38Minor allele frequency- C:0.04NS EA NA WA 542
    rs728388161,2
    		--19279691(+) TATACC/TCCTCC 3 -- us2k1 int10--------
    rs1894364031,2
    		--19279695(+) CCCCTC/TCAACA 3 -- int1 us2k10--------
    rs1482541411,2
    		--19279840(+) CAGCAC/TTTTGG 5 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for MAPK7 (19281034 - 19286857 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAPK7: --

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    Disorders / Diseases
    for MAPK7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPK7 for disorders           About GeneDecksing

    OMIM gene information: 602521    OMIM disorders: --

    20/28 diseases for MAPK7 (see all 28):    About MalaCards
    smith-magenis syndrome    multiple endocrine neoplasia    oral squamous cell carcinoma    squamous cell carcinoma
    dilated cardiomyopathy    hodgkin's lymphoma    multiple myeloma    prostate cancer
    prostate cancer, progression of    synovitis    hepatitis c    cardiomyopathy
    hepatitis b    breast cancer    myeloma    medulloblastoma
    hepatocellular carcinoma    t-cell leukemia    prostatitis    ovarian cancer

    10/12 Novoseek disease relationships for MAPK7 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    men 2a 36.2 2 11237712 (2)
    multiple endocrine neoplasia 29.3 1 11237712 (1)
    hyperalgesia 8.04 4 17573825 (3)
    tumors 4.85 6 18071319 (1), 8663194 (1), 12219026 (1), 18472963 (1) (see all 5)
    leukemia 0 2 15608616 (2)
    necrosis 0 3 8663194 (1), 12219026 (1), 15367687 (1)
    inflammation 0 7 17573825 (5)
    breast cancer 0 4 17483331 (1), 17692050 (1)
    metastasis 0 3 18472963 (2), 18071319 (1)
    prostate cancer 0 8 18071319 (5), 19855844 (2), 17406359 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAPK7 (6 documents)

    Export disorders for MAPK7 gene to outside databases

    Publications
    for MAPK7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK7 gene, integrated from 9 sources (see all 209):
    (articles sorted by number of sources associating them with MAPK7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Components of a new human protein kinase signal transduction pathway. (PubMed id 7759517)1, 2, 3, 9 Zhou G.... Dixon J.E. (1995)
    2. Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival. (PubMed id 11278431)1, 2, 9 Dong F.... Larner A.C. (2001)
    3. Primary structure of BMK1: a new mammalian map kinase. (PubMed id 7646528)1, 2, 9 Lee J.-D.... Han J. (1995)
    4. Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. (PubMed id 9790194)1, 2, 9 Kato Y....Lee J.-D. (1998)
    5. Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant. (PubMed id 15716121)1, 2, 9 McCaw B.J.... Guy G.R. (2005)
    6. BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase. (PubMed id 11254654)1, 2 Hayashi M....Lee J.D. (2001)
    7. Assignment of big MAP kinase (PRKM7) to human chromosome 17 band p11.2 with somatic cell hybrids. (PubMed id 10072598)1, 3 Purandare S.M....Patel P.I. (1998)
    8. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. (PubMed id 9384584)1, 2 Kato Y....Lee J.-D. (1997)
    9. Activation of ERK5 in angiotensin II-induced hypertrophy of human aortic smooth muscle cells. (PubMed id 19011954)1, 9 Zhao Z....Kang W. (2009)
    10. ERK5 differentially regulates PDGF-induced proliferation and migration of hepatic stellate cells. (PubMed id 17998143)1, 9 Rovida E....Marra F. (2008)

    External Searches for MAPK7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAPK7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5598 HGNC: 6880 AceView: MAPK7 Ensembl:ENSG00000166484 euGenes: HUgn5598
    ECgene: MAPK7 Kegg: 5598 H-InvDB: MAPK7

    Other Databases showing MAPK7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAPK7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK7 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAPK7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPK7 gene:
    Search GeneIP for patents involving MAPK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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