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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK7 Gene

protein-coding   GIFtS: 73
GCID: GC17P019281

Mitogen-Activated Protein Kinase 7


(Previous symbol: PRKM7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase 71 2     BMK12 3
PRKM71 2 3 5     ERK-52 3
ERK52 3 5     MAP Kinase 72 3
BMK1 Kinase1 2     MAPK 72 3
Extracellular-Signal-Regulated Kinase 51 2     EC 2.7.11.243 8
Big MAP Kinase 12 3     ERK42
Extracellular Signal-Regulated Kinase 52 3     EC 2.7.118
BMK-12 3     

External Ids:    HGNC: 68801   Entrez Gene: 55982   Ensembl: ENSG000001664847   OMIM: 6025215   UniProtKB: Q131643   

Export aliases for MAPK7 gene to outside databases

Previous GC identifers: GC17P019413 GC17P020752 GC17P019185 GC17P019443 GC17P019221 GC17P018660


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPK7 Gene:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. This kinase is specifically activated by
mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of
various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to
extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by
phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants
of this gene encoding two distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPK7 Gene: 
MAPK7 (mitogen-activated protein kinase 7) is a protein-coding gene. Diseases associated with MAPK7 include hiv-1, resistance to, and hypertrophic scars, and among its related super-pathways are MAPK signaling pathway and Gap junction. GO annotations related to this gene include MAP kinase activity and mitogen-activated protein kinase binding. An important paralog of this gene is MAPK4.

UniProtKB/Swiss-Prot: MK07_HUMAN, Q13164
Function: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The
upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and
phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and
MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial
function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and
not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth
factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2
interaction

summary for MAPK7 Gene:
Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate
intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol
esters. They are expressed in all tissues, at varying levels. Upon activation byMEK, ERK1 and 2 translocate
to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as
p90 RSK.

Gene Wiki entry for MAPK7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK7 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAPK7 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

MAPK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P019281:  view genomic region     (about GC identifiers)

Start:
19,281,034 bp from pter      End:
19,286,857 bp from pter
Size:
5,824 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MK07_HUMAN, Q13164 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 7  
Size: 816 amino acids; 88386 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with MAP2K5. Forms oligomers (By similarity). Interacts with MEF2A, MEF2C and MEF2D; the
interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D (By
similarity). Interacts with SGK1. Preferentially interacts with PML isoform PML-4 but shows interaction also with
its other isoforms: isoform PML-1, isoform PML-2, isoform PML-3 and isoform PML-6
Subcellular location: Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation
Sequence caution: Sequence=AAA81381.1; Type=Frameshift; Positions=19, 32; Sequence=BAD92848.1; Type=Erroneous
initiation;
3 PDB 3D structures from and Proteopedia for MAPK7:
4B99 (3D)        4IC7 (3D)        4IC8 (3D)    
Secondary accessions: Q16634 Q59F50 Q6QLU7 Q7L4P4 Q969G1 Q96G51
Alternative splicing: 4 isoforms:  Q13164-1   Q13164-2   Q13164-3   Q13164-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAPK7: NX_Q13164

Explore proteomics data for MAPK7 at MOPED 

Post-translational modifications:

  • UniProtKB: Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in
    vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory
    role, is absent
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13164

  • 4/14 DME Specific Peptides for MAPK7 (Q13164) (see all 14)
     LKIGDFG  VIHRDLK  YVATRWYR  NIIAIKDI 

    MAPK7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAPK7 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_002740.2  NP_620601.1  NP_620602.2  NP_620603.2  

    ENSEMBL proteins: 
     ENSP00000299612   ENSP00000378966   ENSP00000462819   ENSP00000412902   ENSP00000378968  
     ENSP00000458146   ENSP00000462804   ENSP00000474397   ENSP00000311005  
    Reactome Protein details: Q13164
    Human Recombinant Protein Products for MAPK7: 
    EMD Millipore Purified and/or Recombinant MAPK7 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAPK7
    OriGene Protein Over-expression Lysate for MAPK7
    OriGene MassSpec for MAPK7 
    OriGene Custom Protein Services for MAPK7
    GenScript Custom Purified and Recombinant Proteins Services for MAPK7
    Novus Biologicals MAPK7 Proteins
    Novus Biologicals MAPK7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAPK7 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18588859
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0016020membrane ----

    MAPK7 for ontologies           About GeneDecksing



    MAPK7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK7
    R&D Systems Antibodies for MAPK7 (ERK5/BMK1)
    Cell Signaling Technology (CST) Antibodies for MAPK7  (ERK5)
    OriGene Antibodies for MAPK7
    OriGene Custom Antibody Services for MAPK7
    GenScript Custom Superior Antibodies Services for MAPK7
    Novus Biologicals MAPK7 Antibodies
    Abcam antibodies for MAPK7
    Cloud-Clone Corp. Antibodies for MAPK7 
    ThermoFisher Antibody for MAPK7
    LSBio Antibodies in human, mouse, rat for MAPK7 

    Assay Products for MAPK7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAPK7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAPK7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK7 
    Cloud-Clone Corp. CLIAs for MAPK7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 7 
    ERK subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR003527 MAP_kinase_CS

    Graphical View of Domain Structure for InterPro Entry Q13164

    ProtoNet protein and cluster: Q13164

    1 Blocks protein domain: IPB003527 MAP kinase

    UniProtKB/Swiss-Prot: MK07_HUMAN, Q13164
    Domain: The second proline-rich region may interact with actin targeting the kinase to a specific location in the
    cell
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK07_HUMAN, Q13164
    Function: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The
    upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and
    phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and
    MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial
    function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and
    not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth
    factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2
    interaction
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by tyrosine and threonine phosphorylation (By similarity). Activated in response to
    hyperosmolarity, hydrogen peroxide, and epidermal growth factor (EGF)

         Genatlas biochemistry entry for MAPK7:
    mitogen-activated protein kinase 7,extracellular signal regulated kinase 5 with three alternatively spliced
    isoforms,abundantly expressed in heart,placenta,kidney,skeletal muscle,involved in signal transduction,deleted in
    Smith-Magenis syndrome,involved in the transcriptional activation of factors modulating expression of genes
    required for cell proliferation

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004707MAP kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI18588859
         
    MAPK7 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAPK7:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability with TRAIL  Increased colony dispersion (i 
     Synthetic lethal with Ras 

         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Mapk7):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  homeostasis/metabolism  integument  mortality/aging 
     muscle  nervous system  normal 

    MAPK7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAPK7: Mapk7tm1Jsca Mapk7tm1.1Jdl Mapk7tm1Kda Mapk7tm1Wnt

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAPK7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAPK7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK7 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPK7:
    hsa-mir-143 (MIRT003759)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK7
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK7 (see all 10):
    hsa-miR-429 hsa-miR-4251 hsa-miR-513a-5p hsa-miR-124 hsa-miR-200c hsa-miR-143 hsa-miR-205* hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidMAPK7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAPK7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK7
    Sirion Biotech Customized adenovirus for overexpression of MAPK7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAPK7 (see all 23)
    OriGene ORF clones in mouse, rat for MAPK7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK7 (NM_139032)
    Sino Biological Human cDNA Clone for MAPK7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK7
    Sirion Biotech Customized lentivirus for stable overexpression of MAPK7 
                         Customized lentivirus expression plasmids for stable overexpression of MAPK7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK7
    Search LifeMap BioReagents cell lines for MAPK7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAPK7 About   (see all 59)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Signaling in Gap Junctions
    Signaling in Gap Junctions0.31
    Gap junction0.31
    3TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 5 (TLR5) Cascade0.93
    MyD88-independent cascade 0.87
    MyD88 cascade initiated on plasma membrane0.93
    Toll Like Receptor 3 (TLR3) Cascade0.87
    Toll Like Receptor 10 (TLR10) Cascade0.93
    Toll Like Receptor 4 (TLR4) Cascade0.87
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll-Like Receptors Cascades0.87
    4ErbB4 Pathway
    ErbB4 Pathway0.59
    ErbB2-ErbB3 Heterodimers0.49
    ErbB Family Pathway0.59
    IL-2 Pathway0.48
    Prolactin Signaling0.54
    HMGB1 Pathway0.36
    Thrombopoietin Pathway0.51
    PI3K Signaling in B-Lymphocyte0.35
    5ERK/MAPK targets
    ERK/MAPK targets0.88
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    Nuclear Events (kinase and transcription factor activation)0.88
    ERKs are inactivated0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for MAPK7
        Immune response Function of MEF2 in T lymphocytes
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK7 (see all 56)
        14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    eIF2 Pathway
    G12-G13 in Cellular Signaling

    2 Cell Signaling Technology (CST) Pathways for MAPK7
        MAP Kinase Signaling
    Neuroscience

    2 Tocris Bioscience Pathways for MAPK7
        Insulin Pathway
    Toll-like Receptor Pathway

    2 GeneGo (Thomson Reuters) Pathways for MAPK7
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes

    5/12 BioSystems Pathways for MAPK7 (see all 12)
        MAPK signaling pathway
    Focal Adhesion
    MicroRNAs in cardiomyocyte hypertrophy
    EGFR1 Signaling Pathway
    Insulin Signaling


    5/31        Reactome Pathways for MAPK7 (see all 31)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 7/8 (TLR7/8) Cascade

    1 PharmGKB Pathway for MAPK7
        VEGF Signaling Pathway

    5         Kegg Pathways  (Kegg details for MAPK7):
        MAPK signaling pathway
    Gap junction
    Neurotrophin signaling pathway
    GnRH signaling pathway
    MicroRNAs in cancer


    MAPK7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for MAPK7 (Q131641, 2, 3 ENSP000003110054) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PMLP295901, 3, ENSP000002680584EBI-1213983,EBI-295890 I2D: score=1 STRING: ENSP00000268058
    MAP2K5Q131631, 3, ENSP000001786404EBI-1213983,EBI-307294 I2D: score=4 STRING: ENSP00000178640
    YWHABP319462, 3, ENSP000003001614MINT-8006540 I2D: score=3 STRING: ENSP00000300161
    GJA1P173023, ENSP000002825614I2D: score=3 STRING: ENSP00000282561
    GOLGB1Q147893, ENSP000003418484I2D: score=3 STRING: ENSP00000341848
    About this table

    Gene Ontology (GO): 5/40 biological process terms (GO ID links to tree view) (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process IEA--

    MAPK7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK7 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK7:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MAPK7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    XMD 8-92Selective ERK5/BMK1 inhibitor[1234480-50-2]
    FR 180204Selective ERK inhibitor[865362-74-9]
    PluripotinDual ERK1/RasGAP inhibitor. Maintains ESC self-renewal[839707-37-8]
    TCS ERK 11ePotent and selective ERK2 inhibitor[896720-20-0]

    3 HMDB Compounds for MAPK7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    10/12 Novoseek inferred chemical compound relationships for MAPK7 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,3,4,6-tetrakisphosphate 80.4 3 16293229 (1), 12223481 (1)
    pd-184352 79.5 4 18071319 (1), 11478941 (1), 15381709 (1), 18358237 (1)
    pd 98,059 65.9 16 10473620 (1), 11160424 (1), 12637502 (1), 11782488 (1) (see all 11)
    pip2 53.6 2 8666584 (1), 16878701 (1)
    tyrosine 43.4 7 10473620 (2), 17573825 (1), 9089215 (1), 12755958 (1) (see all 6)
    phosphatidylinositol 35.7 12 17872495 (1), 19951917 (1), 7637540 (1), 2154447 (1) (see all 5)
    phosphoinositide 32.6 1 2154447 (1)
    wortmannin 23.3 2 11237712 (1)
    genistein 18 3 18761399 (1), 11278431 (1), 16758967 (1)
    serine 3.61 1 18322228 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK7 / MK07

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAPK7 gene (4 alternative transcripts): 
    NM_002749.3  NM_139032.2  NM_139033.2  NM_139034.2  

    Unigene Cluster for MAPK7:

    Mitogen-activated protein kinase 7
    Hs.150136  [show with all ESTs]
    Unigene Representative Sequence: NM_139033
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299612 ENST00000571657 ENST00000573417 ENST00000395602(uc002gvq.3)
    ENST00000579284 ENST00000443215 ENST00000395604(uc002gvp.3) ENST00000572968
    ENST00000573466 ENST00000482850 ENST00000581260 ENST00000570306 ENST00000486905
    ENST00000572853 ENST00000603493 ENST00000490660 ENST00000572716 ENST00000308406(uc002gvn.3 uc002gvo.3)

    miRNA
    Products:
         
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK7 (see all 10):
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    Additional mRNA sequence: 

    AK295376.1 BC007404.2 BC007992.2 BC009963.2 BC030134.1 U25278.1 U29725.1 U29726.1 

    16 DOTS entries:

    DT.100824041  DT.91754809  DT.95364060  DT.95113377  DT.100770627  DT.100781325  DT.120954292  DT.100781332 
    DT.75185652  DT.100781330  DT.120954354  DT.91754814  DT.120954290  DT.95364050  DT.95364057  DT.99955532 

    24/184 AceView cDNA sequences (see all 184):

    AI199627 U29726 BC007992 U29725 BQ949098 CR592256 BU682475 BX451533 
    CA418953 BC007404 BM845337 CR604533 AL045025 BC030134 NM_139032 BM844995 
    AY534741 BU178205 AI094886 BU151492 BM718594 T09243 AA503767 NM_139033 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK7 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                          -     -     -     -     -                 -     -     -     -     -                                                               
    SP2:                                      -     -     -                 -     -     -     -     -                                                               
    SP3:                                      -     -     -                 -     -     -     -     -                                                               
    SP4:                                                  -                 -     -     -     -     -                                                               
    SP5:                                            -     -                 -     -     -                                                                           


    ECgene alternative splicing isoforms for MAPK7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK7 expression in normal human tissues (normalized intensities)      MAPK7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGATCGG
    MAPK7 Expression
    About this image


    MAPK7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Liver (Hepatobiliary System)
             Liver Bud
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Thymus (Hematopoietic System)

    See MAPK7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK7

    SOURCE GeneReport for Unigene cluster: Hs.150136

    UniProtKB/Swiss-Prot: MK07_HUMAN, Q13164
    Tissue specificity: Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal
    muscle. Not detectable in liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK7: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK7 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk71 , 5 mitogen-activated protein kinase 71, 5 86.68(n)1
    93.05(a)1
      11 (37.96 cM)5
    239391  NM_011841.11  NP_035971.11 
     614888125 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK76
    Uncharacterized protein
    63(a)
    1 ↔ 1
    GL343220.1(1649808-1663437)
    zebrafish
    (Danio rerio)
    Actinopterygii mapk71 mitogen-activated protein kinase 7 59.95(n)
    60.34(a)
      541323  NM_001013451.2  NP_001013469.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F09C12.23 Ser/Thr protein kinase 40(a)   II(5110015-5114112)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KDX1(YKL161C)4
    SLT21
    Protein kinase implicated in the Slt2p mitogen-activated more4
    Slt2p1
    48.06(n)1
    43.94(a)1
      11(150687-149386)4
    8564251  NP_011895.11  8536964 
     NP_012761.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MPK41 mitogen-activated protein kinase 4 54.49(n)
    54.79(a)
      828151  NM_116367.2  NP_192046.1 
    rice
    (Oryza sativa)
    Liliopsida AK111579.12   -- 75.12(n)    AK111579.1 


    ENSEMBL Gene Tree for MAPK7 (if available)
    TreeFam Gene Tree for MAPK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK7 gene
    MAPK42  MAPK32  NLK2  MAPK152  MAPK62  MAPK12  
    18/60 SIMAP similar genes for MAPK7 using alignment to 5 protein entries:     MK07_HUMAN (see all proteins) (see all similar genes):
    PHKG2    DKFZp686O0215    MAPK4    MAPK1    MAPK3    MAPK14
    MAPK11    DYRK4    CCRK    NDUFA9    MAPK13    TXK
    CDKL3    CDK3    CDK20    CDK7    MAP4K5    PNCK

    MAPK7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/125 SNPs in MAPK7 are shown (see all 125)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0462254
    ----see VAR_0462252 R H mis40--------
    rs1877323921,2
    --19283581(+) GACAAG/TCCTGG 4 -- int10--------
    rs1180059371,2
    F--19283612(+) TCAAGC/ATGCCA 4 -- int11Minor allele frequency- A:0.01NA 120
    rs1496984871,2
    --19283750(+) AAGTCA/GTAGAG 4 -- int10--------
    rs1458006121,2
    --19283789(+) ACCATA/GCCGTC 4 -- int10--------
    rs1489892901,2
    C--19283802(+) CCCCTA/GTGGGG 4 -- int10--------
    rs1429689281,2
    --19283840(+) GAATCA/GGAAGG 4 -- int10--------
    rs2003048731,2
    C--19283875(+) CTGGAC/GTGTGA 4 -- int10--------
    rs1998004971,2
    --19284023(+) CTGCTA/GCGGGG 8 L syn10--------
    rs22330741,2
    C,F,H--19284071(+) GACCTG/CAAGCC 8 /L syn1 ese38Minor allele frequency- C:0.03EA NS CSA NA 6562

    HapMap Linkage Disequilibrium report for MAPK7 (19281034 - 19286857 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MAPK7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv907864CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602521    OMIM disorders: --

    20/31 diseases for MAPK7 (see all 31):    About MalaCards
    hiv-1, resistance to    hypertrophic scars    multiple endocrine neoplasia    prostate cancer, progression of
    smith magenis syndrome    synovitis    dilated cardiomyopathy    oral squamous cell carcinoma
    prostate cancer    medulloblastoma    multiple myeloma    myeloma
    endotheliitis    hepatitis c    t-cell leukemia    prostatitis
    hepatitis    hypoxia    hodgkin's lymphoma    squamous cell carcinoma


    MAPK7 for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for MAPK7 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    men 2a 36.2 2 11237712 (2)
    multiple endocrine neoplasia 29.3 1 11237712 (1)
    hyperalgesia 8.04 4 17573825 (3)
    tumors 4.85 6 18071319 (1), 8663194 (1), 12219026 (1), 18472963 (1) (see all 5)
    leukemia 0 2 15608616 (2)
    necrosis 0 3 8663194 (1), 12219026 (1), 15367687 (1)
    inflammation 0 7 17573825 (5)
    breast cancer 0 4 17483331 (1), 17692050 (1)
    metastasis 0 3 18472963 (2), 18071319 (1)
    prostate cancer 0 8 18071319 (5), 19855844 (2), 17406359 (1)

    Genetic Association Database (GAD): MAPK7
    Human Genome Epidemiology (HuGE) Navigator: MAPK7 (6 documents)

    Export disorders for MAPK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK7 gene, integrated from 9 sources (see all 218):
    (articles sorted by number of sources associating them with MAPK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Components of a new human protein kinase signal transduction pathway. (PubMed id 7759517)1, 2, 3, 9 Zhou G.... Dixon J.E. (1995)
    2. Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival. (PubMed id 11278431)1, 2, 9 Dong F.... Larner A.C. (2001)
    3. Primary structure of BMK1: a new mammalian map kinase. (PubMed id 7646528)1, 2, 9 Lee J.-D.... Han J. (1995)
    4. Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. (PubMed id 9790194)1, 2, 9 Kato Y....Lee J.-D. (1998)
    5. Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant. (PubMed id 15716121)1, 2, 9 McCaw B.J.... Guy G.R. (2005)
    6. BMK1 is involved in the regulation of p53 through disrupting the PML- MDM2 interaction. (PubMed id 22869143)1, 2 Yang Q....Lee J.D. (2012)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase. (PubMed id 11254654)1, 2 Hayashi M....Lee J.D. (2001)
    9. Assignment of big MAP kinase (PRKM7) to human chromosome 17 band p11.2 with somatic cell hybrids. (PubMed id 10072598)1, 3 Purandare S.M....Patel P.I. (1998)
    10. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. (PubMed id 9384584)1, 2 Kato Y....Lee J.-D. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5598 HGNC: 6880 AceView: MAPK7 Ensembl:ENSG00000166484 euGenes: HUgn5598
    ECgene: MAPK7 Kegg: 5598 H-InvDB: MAPK7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAPK7 gene:
    Search GeneIP for patents involving MAPK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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