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Aliases for MAPK7 Gene

Aliases for MAPK7 Gene

  • Mitogen-Activated Protein Kinase 7 2 3 5
  • Extracellular-Signal-Regulated Kinase 5 2 3
  • Extracellular Signal-Regulated Kinase 5 3 4
  • Big MAP Kinase 1 3 4
  • MAP Kinase 7 3 4
  • EC 2.7.11.24 4 63
  • BMK1 Kinase 2 3
  • MAPK 7 3 4
  • PRKM7 3 4
  • BMK-1 3 4
  • ERK-5 3 4
  • BMK1 3 4
  • ERK5 3 4
  • EC 2.7.11 63
  • ERK4 3

External Ids for MAPK7 Gene

Previous HGNC Symbols for MAPK7 Gene

  • PRKM7

Previous GeneCards Identifiers for MAPK7 Gene

  • GC17P019413
  • GC17P020752
  • GC17P019185
  • GC17P019443
  • GC17P019221
  • GC17P018660
  • GC17P019281

Summaries for MAPK7 Gene

Entrez Gene Summary for MAPK7 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK7 Gene

MAPK7 (Mitogen-Activated Protein Kinase 7) is a Protein Coding gene. Diseases associated with MAPK7 include caroli disease. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK1.

UniProtKB/Swiss-Prot for MAPK7 Gene

  • Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

Tocris Summary for MAPK7 Gene

  • Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.

Gene Wiki entry for MAPK7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK7 Gene

Genomics for MAPK7 Gene

Regulatory Elements for MAPK7 Gene

Promoters for MAPK7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAPK7 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MAPK7 gene promoter:

Genomic Location for MAPK7 Gene

Chromosome:
17
Start:
19,377,721 bp from pter
End:
19,383,544 bp from pter
Size:
5,824 bases
Orientation:
Plus strand

Genomic View for MAPK7 Gene

Genes around MAPK7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK7 Gene

Proteins for MAPK7 Gene

  • Protein details for MAPK7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13164-MK07_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 7
    Protein Accession:
    Q13164
    Secondary Accessions:
    • Q16634
    • Q59F50
    • Q6QLU7
    • Q7L4P4
    • Q969G1
    • Q96G51

    Protein attributes for MAPK7 Gene

    Size:
    816 amino acids
    Molecular mass:
    88386 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MAP2K5. Forms oligomers (By similarity). Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D (By similarity). Interacts with SGK1. Preferentially interacts with PML isoform PML-4 but shows interaction also with its other isoforms: isoform PML-1, isoform PML-2, isoform PML-3 and isoform PML-6.
    SequenceCaution:
    • Sequence=AAA81381.1; Type=Frameshift; Positions=19, 32; Evidence={ECO:0000305}; Sequence=BAD92848.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAPK7 Gene

    Alternative splice isoforms for MAPK7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK7 Gene

Proteomics data for MAPK7 Gene at MOPED

Post-translational modifications for MAPK7 Gene

  • Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPK7 (ERK5)
  • Cloud-Clone Corp. Antibodies for MAPK7

Domains & Families for MAPK7 Gene

Suggested Antigen Peptide Sequences for MAPK7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13164

UniProtKB/Swiss-Prot:

MK07_HUMAN :
  • The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell.
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK7: view

Function for MAPK7 Gene

Molecular function for MAPK7 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase 7,extracellular signal regulated kinase 5 with three alternatively spliced isoforms,abundantly expressed in heart,placenta,kidney,skeletal muscle,involved in signal transduction,deleted in Smith-Magenis syndrome,involved in the transcriptional activation of factors modulating expression of genes required for cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by tyrosine and threonine phosphorylation (By similarity). Activated in response to hyperosmolarity, hydrogen peroxide, and epidermal growth factor (EGF).
UniProtKB/Swiss-Prot Function:
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

Enzyme Numbers (IUBMB) for MAPK7 Gene

genes like me logo Genes that share phenotypes with MAPK7: view

Animal Models for MAPK7 Gene

MGI Knock Outs for MAPK7:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK7 Gene

Localization for MAPK7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK7 Gene

Cytoplasm. Nucleus. Nucleus, PML body. Note=Translocates to the nucleus upon activation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK7 Gene COMPARTMENTS Subcellular localization image for MAPK7 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAPK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0016605 PML body IDA 22869143
genes like me logo Genes that share ontologies with MAPK7: view

Pathways & Interactions for MAPK7 Gene

SuperPathways for MAPK7 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 IL-2 Pathway
3 GPCR Pathway
4 Apoptotic Pathways in Synovial Fibroblasts
5 MAPK targets/ Nuclear events mediated by MAP kinases
genes like me logo Genes that share pathways with MAPK7: view

SIGNOR curated interactions for MAPK7 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAPK7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS 7646528
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with MAPK7: view

Drugs & Compounds for MAPK7 Gene

(9) Drugs for MAPK7 Gene - From: HMDB, Novoseek, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
XMD8-92 Pharma BMK1/ERK5 inhibitor,highly selective, Selective ERK5/BMK1 inhibitor 0
Magnesium Nutra 0
FR 180204 Pharma ERK inhibitor, Selective ERK inhibitor 0

(11) Additional Compounds for MAPK7 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Pluripotin
839707-37-8
TCS ERK 11e
896720-20-0
TMCB
905105-89-7

(5) Tocris Compounds for MAPK7 Gene

Compound Action Cas Number
FR 180204 Selective ERK inhibitor 865362-74-9
Pluripotin Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal 839707-37-8
TCS ERK 11e Potent and selective ERK2 inhibitor 896720-20-0
TMCB Dual-kinase inhibitor; inhibits CK2 and ERK8 905105-89-7
XMD 8-92 Selective ERK5/BMK1 inhibitor 1234480-50-2

(1) ApexBio Compounds for MAPK7 Gene

Compound Action Cas Number
XMD8-92 BMK1/ERK5 inhibitor,highly selective 1234480-50-2
genes like me logo Genes that share compounds with MAPK7: view

Transcripts for MAPK7 Gene

Unigene Clusters for MAPK7 Gene

Mitogen-activated protein kinase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - - - - - - - - - -
SP8: - - - - -
SP9: -
SP10:
SP11: - - - - - - - - - - - -
SP12:
SP13:
SP14:

Relevant External Links for MAPK7 Gene

GeneLoc Exon Structure for
MAPK7
ECgene alternative splicing isoforms for
MAPK7

Expression for MAPK7 Gene

mRNA expression in normal human tissues for MAPK7 Gene

Protein differential expression in normal tissues from HIPED for MAPK7 Gene

This gene is overexpressed in Plasma (32.4) and Fetal ovary (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAPK7 Gene



SOURCE GeneReport for Unigene cluster for MAPK7 Gene Hs.150136

mRNA Expression by UniProt/SwissProt for MAPK7 Gene

Q13164-MK07_HUMAN
Tissue specificity: Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.
genes like me logo Genes that share expression patterns with MAPK7: view

Protein tissue co-expression partners for MAPK7 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAPK7 Gene

Orthologs for MAPK7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPK7 35
  • 89.62 (n)
  • 98.26 (a)
MAPK7 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK7 35
  • 90.72 (n)
  • 97.91 (a)
MAPK7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk7 35
  • 85.81 (n)
  • 91.94 (a)
Mapk7 16
Mapk7 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAPK7 35
  • 98.97 (n)
  • 98.74 (a)
MAPK7 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk7 35
  • 85.14 (n)
  • 91.36 (a)
oppossum
(Monodelphis domestica)
Mammalia MAPK7 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia MAPK7 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk7 35
  • 67.75 (n)
  • 71.94 (a)
zebrafish
(Danio rerio)
Actinopterygii mapk7 35
  • 65.83 (n)
  • 69.1 (a)
mapk7 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta p38c 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea F09C12.2 37
  • 40 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER232C 35
  • 54.42 (n)
  • 49.57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11902g 35
  • 52.56 (n)
  • 48.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLT2 35
  • 50.9 (n)
  • 49.29 (a)
FUS3 36
  • 47 (a)
ManyToMany
KSS1 36
  • 47 (a)
ManyToMany
KDX1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MPK4 35
  • 55.83 (n)
  • 57.19 (a)
soybean
(Glycine max)
eudicotyledons Gma.3675 35
barley
(Hordeum vulgare)
Liliopsida Hv.5234 35
rice
(Oryza sativa)
Liliopsida Os10g0533600 35
  • 57.22 (n)
  • 53.96 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7205 35
bread mold
(Neurospora crassa)
Ascomycetes NCU11376 35
  • 58.7 (n)
  • 51.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pmk1 35
  • 51.04 (n)
  • 50.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6704 36
  • 36 (a)
OneToOne
Species with no ortholog for MAPK7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MAPK7 Gene

ENSEMBL:
Gene Tree for MAPK7 (if available)
TreeFam:
Gene Tree for MAPK7 (if available)

Paralogs for MAPK7 Gene

Paralogs for MAPK7 Gene

genes like me logo Genes that share paralogs with MAPK7: view

Variants for MAPK7 Gene

Sequence variations from dbSNP and Humsavar for MAPK7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs56388327 - 19,381,949(+) CTCTG(C/G)GGGCC reference, missense
VAR_046225 -
rs1042855 -- 19,382,131(+) GCCCT(C/G)TAGCC reference, missense
rs2233074 -- 19,380,758(+) GACCT(A/C/G)AAGCC reference, synonymous-codon
rs2233075 -- 19,381,337(+) GAGCG(C/T)ATTAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MAPK7 Gene

Variant ID Type Subtype PubMed ID
nsv907864 CNV Loss 21882294

Variation tolerance for MAPK7 Gene

Residual Variation Intolerance Score: 4.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK7 Gene

HapMap Linkage Disequilibrium report
MAPK7
Human Gene Mutation Database (HGMD)
MAPK7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK7 Gene

Disorders for MAPK7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAPK7 Gene - From: GeneCards

Disorder Aliases PubMed IDs
caroli disease
  • caroli disease isolated
- elite association - COSMIC cancer census association via MalaCards
Search MAPK7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAPK7

Genetic Association Database (GAD)
MAPK7
Human Genome Epidemiology (HuGE) Navigator
MAPK7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK7
genes like me logo Genes that share disorders with MAPK7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK7 Gene

Publications for MAPK7 Gene

  1. Components of a new human protein kinase signal transduction pathway. (PMID: 7759517) Zhou G. … Dixon J.E. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. Lipopolysaccharide modifies amiloride-sensitive Na+ transport processes across human airway cells: role of mitogen-activated protein kinases ERK 1/2 and 5. (PMID: 19823867) Baines D.L. … Dockrell M.E. (Pflugers Arch. 2010) 3 23
  3. The ERK5 and ERK1/2 signaling pathways play opposing regulatory roles during chondrogenesis of adult human bone marrow-derived multipotent progenitor cells. (PMID: 20232315) Bobick B.E. … Tuan R.S. (J. Cell. Physiol. 2010) 3 23
  4. ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry. (PMID: 18973138) Zen K. … Yoshikawa T. (Genes Chromosomes Cancer 2009) 3 23
  5. Activation of ERK5 in angiotensin II-induced hypertrophy of human aortic smooth muscle cells. (PMID: 19011954) Zhao Z. … Kang W. (Mol. Cell. Biochem. 2009) 3 23

Products for MAPK7 Gene

Sources for MAPK7 Gene

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