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MAPK6 Gene

protein-coding   GIFtS: 67
GCID: GC15P052311

Mitogen-Activated Protein Kinase 6


(Previous symbol: PRKM6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mitogen-Activated Protein Kinase 61 2     p97-MAPK2 3
PRKM61 2 3     EC 2.7.11.243 8
Extracellular Signal-Regulated Kinase 32 3     HsT172502
ERK-32 3     Extracellular Signal-Regulated Kinase, P972
ERK32 3     p97MAPK2
MAP Kinase 62 3     Protein Kinase, Mitogen-Activated 52
MAP Kinase Isoform P972 3     Protein Kinase, Mitogen-Activated 62
MAPK 62 3     EC 2.7.118

External Ids:    HGNC: 68791   Entrez Gene: 55972   Ensembl: ENSG000000699567   OMIM: 6029045   UniProtKB: Q166593   
ORGUL members:         

Export aliases for MAPK6 gene to outside databases

Previous GC identifers: GC15P047869 GC15P045358 GC15P049890 GC15P050027 GC15P050098 GC15P029169


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK6 Gene:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to
mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases
(ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple
biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in
fibroblasts upon treatment with serum or phorbol esters. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPK6 Gene:
MAPK6 (mitogen-activated protein kinase 6) is a protein-coding gene. Diseases associated with MAPK6 include pulmonary immaturity, and acinar cell carcinoma. GO annotations related to this gene include protein kinase binding and protein heterodimerization activity. An important paralog of this gene is MAPK4.

UniProtKB/Swiss-Prot: MK06_HUMAN, Q16659
Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise
role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of
phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then
mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry
in the cell cycle (By similarity)

Gene Wiki entry for MAPK6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK6 gene promoter:
         Egr-3   ER-alpha   NF-AT   CREB   NF-AT4   NF-AT2   Sox9   NF-AT3   ARP-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPK6 promoter sequence
   Search Chromatin IP Primers for MAPK6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21

MAPK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK6 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P052311:  view genomic region     (about GC identifiers)

Start:
52,244,303 bp from pter      End:
52,358,462 bp from pter
Size:
114,160 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MK06_HUMAN, Q16659 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 6  
Size: 721 amino acids; 82681 Da
Cofactor: Magnesium (By similarity)
Subunit: Heterodimer with ERK4/MAPK4. Interacts with (via FRIEDE motif) MAPKAPK5 (By similarity). Interacts with
UBE3A; this interaction may be indirect and mediated by HERC2, possibly via HERC2 interaction with NEURL4
1 PDB 3D structure from and Proteopedia for MAPK6:
2I6L (3D)    
Secondary accessions: B2R945 B5BU65 Q68DH4 Q8IYN8

Explore the universe of human proteins at neXtProt for MAPK6: NX_Q16659

Explore proteomics data for MAPK6 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at
    other sites1
  • Ubiquitination at Met-1 leads to degradation by the proteasome pathway1
  • Ubiquitination2 at Lys4, Lys447, Lys471, Lys480, Lys517, Lys563, Lys631, Lys672, Lys691, Lys703
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPK6 (Q16659) (see all 18)
     LKYIHSA  RVAIKKI  VLHRDLK  LKIGDFG 


    See MAPK6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002739.1  
    ENSEMBL proteins: 
     ENSP00000261845  

    MAPK6 Human Recombinant Protein Products:

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    Novus Biologicals MAPK6 Proteins
    Novus Biologicals MAPK6 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAPK6

    MAPK6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK6
    R&D Systems Antibodies for MAPK6 (ERK3)
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    OriGene Antibodies for MAPK6
    OriGene Custom Antibody Services for MAPK6
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    LSBio Antibodies in human, mouse, rat for MAPK6

    MAPK6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAPK6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK6
    Cloud-Clone Corp. CLIAs for MAPK6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 6
    ERK subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q16659

    ProtoNet protein and cluster: Q16659

    1 Blocks protein domain: IPB008350 ERK3/4 MAP kinase signature

    UniProtKB/Swiss-Prot: MK06_HUMAN, Q16659
    Domain: In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif,
    whose phosphorylation activates the MAP kinases (By similarity)
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK06_HUMAN, Q16659
    Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise
    role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of
    phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then
    mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry
    in the cell cycle (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation at Ser-189

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS2032290
    GO:0004707MAP kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    MAPK6 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAPK6:
     Decreased substrate adherent c  Decreased viability  Increased mitotic index 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mapk6):
     behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism  integument 
     liver/biliary system  mortality/aging  respiratory system  skeleton 

    MAPK6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPK6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK6

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPK6:
    hsa-mir-100-5p (MIRT048392), hsa-mir-128-3p (MIRT021894), hsa-mir-15a-5p (MIRT051334), hsa-mir-99a-5p (MIRT048608)

    Block miRNA regulation of human, mouse, rat MAPK6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK6 (see all 67):
    hsa-miR-548j hsa-miR-128 hsa-miR-374a hsa-miR-632 hsa-miR-519a hsa-miR-548a-5p hsa-miR-3148 hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmidMAPK6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPK6
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK6

    Clone
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    OriGene clones in human, mouse for MAPK6 (see all 9)
    OriGene ORF clones in mouse, rat for MAPK6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK6 (NM_002748)
    Sino Biological Human cDNA Clone for MAPK6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK6

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MK06_HUMAN, Q16659: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates to the cytoplasm
    following interaction with MAPKAPK5 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    MAPK6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK6 About   (see all 41)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB4 Pathway
    ErbB4 Pathway0.59
    ErbB2-ErbB3 Heterodimers0.49
    ErbB Family Pathway0.59
    IL-2 Pathway0.48
    Prolactin Signaling0.54
    HMGB1 Pathway0.36
    Thrombopoietin Pathway0.51
    PI3K Signaling in B-Lymphocyte0.35
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    GPCR Pathway0.62
    NFAT in Immune Response0.58
    Pancreatic Adenocarcinoma0.59
    3Apoptotic Pathways in Synovial Fibroblasts
    Glioma Invasiveness0.64
    Rap1 Pathway0.57
    eIF2 Pathway0.60
    4Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    14-3-3 Induced Intracellular Signaling0.59
    5PEDF Induced Signaling
    IL-6 Pathway0.61
    Endothelin-1 Signaling Pathway0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK6 (see all 55)
        14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    eIF2 Pathway
    G12-G13 in Cellular Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK6
        MAP Kinase Signaling

    2 Tocris Bioscience Pathways for MAPK6
        Insulin Pathway
    Toll-like Receptor Pathway

    Selected BioSystems Pathways for MAPK6 (see all 6)
        MAPK signaling pathway
    Focal Adhesion
    Integrin-mediated cell adhesion
    Signal Transduction of S1P Receptor
    Insulin Signaling


    1 PharmGKB Pathway for MAPK6
        VEGF Signaling Pathway


    MAPK6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MAPK6: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK6 (Q166591, 2, 3 ENSP000002618454) via UniProtKB, MINT, STRING, and/or I2D (see all 295)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPKAPK5Q8IW411, 2, 3EBI-1384105,EBI-1201460 MINT-8261384 I2D: score=5 
    DDR1Q083452, 3MINT-8260966 I2D: score=2 
    ENSG00000137332Q083452, 3MINT-8260966 I2D: score=2 
    ENSG00000215522Q083452, 3MINT-8260966 I2D: score=2 
    ENSG00000230456Q083452, 3MINT-8260966 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0006468protein phosphorylation ISS--
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction TAS2032290

    MAPK6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPK6 (MK06)

    3 HMDB Compounds for MAPK6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for MAPK6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 38.6 2 12915405 (1), 12504858 (1)
    serine 24.5 2 12915405 (1), 12504858 (1)



    MAPK6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAPK6 gene: 
    NM_002748.3  

    Unigene Cluster for MAPK6:

    Mitogen-activated protein kinase 6
    Hs.411847  [show with all ESTs]
    Unigene Representative Sequence: NM_002748
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560802 ENST00000558063 ENST00000560254 ENST00000261845(uc002abp.3)
    ENST00000558100 ENST00000558841 ENST00000558891 ENST00000560774
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAPK6 (see all 67):
    hsa-miR-548j hsa-miR-128 hsa-miR-374a hsa-miR-632 hsa-miR-519a hsa-miR-548a-5p hsa-miR-3148 hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmidMAPK6 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: MAPK6 (NM_002748)
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    Primer
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    OriGene qPCR primer pairs and template standards for MAPK6
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK6
      QuantiTect SYBR Green Assays in human, mouse, rat MAPK6
      QuantiFast Probe-based Assays in human, mouse, rat MAPK6

    Additional mRNA sequence: 

    AB451301.1 AF420474.1 AJ251709.1 AK313633.1 BC035492.2 CR749401.1 L77964.1 X80692.1 

    10 DOTS entries:

    DT.100017169  DT.95069177  DT.121077095  DT.121077106  DT.121077161  DT.91762974  DT.95253212  DT.100680321 
    DT.121621644  DT.99960657 

    Selected AceView cDNA sequences (see all 264):

    BF062316 BI757105 AI696041 CA432548 BX474858 BQ212643 BC035492 AI251105 
    CA449987 AA251095 AW069490 AL704923 CK429196 BM479484 CA411718 T32837 
    BG493160 F12584 AA758456 N48784 BM472514 F10200 BG496241 BF002187 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK6    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9
    SP1:        -     -     -                                                   
    SP2:        -     -                                                         
    SP3:              -     -                                                   
    SP4:                    -                                                   


    ECgene alternative splicing isoforms for MAPK6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAPK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAPK6 Expression
    About this image


    MAPK6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Bud
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    MAPK6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.411847

    UniProtKB/Swiss-Prot: MK06_HUMAN, Q16659
    Tissue specificity: Highest expression in the skeletal muscle, followed by the brain. Also found in heart,
    placenta, lung, liver, pancreas, kidney and skin fibroblasts

        Pathway & Disease-focused RT2 Profiler PCR Array including MAPK6: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MAPK6
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK6
    QuantiTect SYBR Green Assays in human, mouse, rat MAPK6
    QuantiFast Probe-based Assays in human, mouse, rat MAPK6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAPK6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk61 , 5 mitogen-activated protein kinase 61, 5 88.13(n)1
    94.99(a)1
      9 (42.30 cM)5
    507721  NM_027418.21  NP_081694.11 
     753690625 
    chicken
    (Gallus gallus)
    Aves MAPK61 mitogen-activated protein kinase 6 87.41(n)
    93.06(a)
      415419  NM_001030549.1  NP_001025720.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK66
    mitogen-activated protein kinase 6
    91(a)
    1 ↔ 1
    GL343998.1(4633-14350)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.239312 Xenopus laevis transcribed sequence with moderate similarity more 81.91(n)    BJ060132.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapk61 mitogen-activated protein kinase 6 69.19(n)
    76.75(a)
      565830  NM_001045552.1  NP_001039017.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KSS16
    FUS36
    Mitogen-activated protein kinase (MAPK) involved i...
    Mitogen-activated serine/threonine protein kinase ...
    35(a)
    35(a)
    many ↔ many
    many ↔ many
    VII(575398-576504) YGR040W
    II(192451-193512) YBL016W


    ENSEMBL Gene Tree for MAPK6 (if available)
    TreeFam Gene Tree for MAPK6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK6 gene
    MAPK42  MAPK32  MAPK72  NLK2  MAPK152  MAPK12  
    9 SIMAP similar genes for MAPK6 using alignment to 1 protein entry:     MK06_HUMAN:
    MAPK4    MAPK14    MAPK13    CDK2    CDK6    CDK4
    CDK7    MAPK9    CDK9

    MAPK6 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for MAPK6 (see all 7)
    PGOHUM00000238785 PGOHUM00000248385 PGOHUM00000239050 PGOHUM00000243765 PGOHUM00000249323


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPK6 (see all 1122)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862501221,2
    --52309498(+) CAATGA/GTTTGG 1 -- us2k10--------
    rs1505310041,2
    C--52309605(+) AGGGTA/GGGGGA 1 -- us2k10--------
    rs20017411,2
    C,F--52309625(+) GTACAT/CTGATC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs757544661,2
    C,F--52310092(+) TGCGGT/CTGGAA 1 -- us2k12Minor allele frequency- C:0.02WA NA 238
    rs557147161,2
    C,F--52310118(+) TCTTGG/TTTTTT 1 -- us2k13Minor allele frequency- T:0.09WA EA 240
    rs1403092271,2
    C--52310167(+) GACGT-/TGTTTTA 1 -- us2k10--------
    rs783325221,2
    C,F--52310268(+) TTTCGC/GCCAGG 1 -- us2k13Minor allele frequency- G:0.09WA EA 240
    rs1165037301,2
    C,F--52310311(+) CAACCC/TCCCGC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs609159721,2
    C--52310423(+) CTTTC-/ACC   
      ATGTTG
    GCCAT
    1 -- us2k11Minor allele frequency- ACCATGTTG:0.00NA 2
    rs750392011,2
    C--52310423(+) CTTTCG/ACCATG 1 -- us2k12Minor allele frequency- A:0.33WA CSA 3

    HapMap Linkage Disequilibrium report for MAPK6 (52244303 - 52358462 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MAPK6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749691CNV Deletion23290073
    dgv340e201CNV Deletion23290073
    esv2351837CNV Deletion18987734
    nsv1536CNV Loss18451855
    nsv471244CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK6
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602904    OMIM disorders: --

    13 diseases for MAPK6:    
    About MalaCards
    pulmonary immaturity    acinar cell carcinoma    glioblastoma multiforme    oral squamous cell carcinoma
    squamous cell carcinoma    colorectal cancer    adenocarcinoma    pancreatitis
    cerebritis    leukemia    breast cancer    neuronitis
    endotheliitis


    MAPK6 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MAPK6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 3 15067337 (3)

    Genetic Association Database (GAD): MAPK6

    Export disorders for MAPK6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK6 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with MAPK6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure, expression and chromosomal locus of a human homolog of rat ERK3. (PubMed id 8875998)1, 2, 3, 9 Meloche S.... Pellerin J. (Oncogene 1996)
    2. N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. (PubMed id 15226418)1, 2, 9 Coulombe P....Meloche S. (Mol. Cell. Biol. 2004)
    3. Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. (PubMed id 22645313)1, 2 Martinez-Noel G.... Howley P.M. (Mol. Cell. Biol. 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3. (PubMed id 7969157)1, 2 Zhu A.X.... Flier J.S. (Mol. Cell. Biol. 1994)
    6. Regulation of ERK3/MAPK6 expression by BRAF. (PubMed id 16964379)1, 9 Hoeflich K.P....Seshagiri S. (Int. J. Oncol. 2006)
    7. Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation. (PubMed id 12808096)1, 9 Coulombe P....Meloche S. (Mol. Cell. Biol. 2003)
    8. Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression. (PubMed id 12915405)1, 9 Julien C....Meloche S. (J. Biol. Chem. 2003)
    9. Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo. (PubMed id 11741894)1, 9 Robinson M.J....Cobb M.H. (J. Biol. Chem. 2002)
    10. Proteasome- and p38-dependent regulation of ERK3 expression. (PubMed id 11148204)1, 9 Zimmermann J....Furst P. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5597 HGNC: 6879 AceView: MAPK6 Ensembl:ENSG00000069956 euGenes: HUgn5597
    ECgene: MAPK6 H-InvDB: MAPK6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAPK6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPK6 gene:
    Search GeneIP for patents involving MAPK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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