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Aliases for MAPK6 Gene

Aliases for MAPK6 Gene

  • Mitogen-Activated Protein Kinase 6 2 3 5
  • Extracellular Signal-Regulated Kinase 3 3 4
  • MAP Kinase Isoform P97 3 4
  • MAP Kinase 6 3 4
  • EC 2.7.11.24 4 63
  • P97-MAPK 3 4
  • MAPK 6 3 4
  • PRKM6 3 4
  • ERK-3 3 4
  • ERK3 3 4
  • Extracellular Signal-Regulated Kinase, P97 3
  • Protein Kinase, Mitogen-Activated 5 3
  • Protein Kinase, Mitogen-Activated 6 3
  • EC 2.7.11 63
  • HsT17250 3
  • P97MAPK 3

External Ids for MAPK6 Gene

Previous HGNC Symbols for MAPK6 Gene

  • PRKM6

Previous GeneCards Identifiers for MAPK6 Gene

  • GC15P047869
  • GC15P045358
  • GC15P049890
  • GC15P050027
  • GC15P050098
  • GC15P052311
  • GC15P029169

Summaries for MAPK6 Gene

Entrez Gene Summary for MAPK6 Gene

  • The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK6 Gene

MAPK6 (Mitogen-Activated Protein Kinase 6) is a Protein Coding gene. Diseases associated with MAPK6 include pulmonary immaturity. Among its related pathways are VEGF Signaling and MAP Kinase Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK1.

UniProtKB/Swiss-Prot for MAPK6 Gene

  • Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).

Gene Wiki entry for MAPK6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK6 Gene

Genomics for MAPK6 Gene

Regulatory Elements for MAPK6 Gene

Enhancers for MAPK6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAPK6 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAPK6 Gene

Chromosome:
15
Start:
51,952,106 bp from pter
End:
52,067,372 bp from pter
Size:
115,267 bases
Orientation:
Plus strand

Genomic View for MAPK6 Gene

Genes around MAPK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK6 Gene

Proteins for MAPK6 Gene

  • Protein details for MAPK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16659-MK06_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 6
    Protein Accession:
    Q16659
    Secondary Accessions:
    • B2R945
    • B5BU65
    • Q68DH4
    • Q8IYN8

    Protein attributes for MAPK6 Gene

    Size:
    721 amino acids
    Molecular mass:
    82681 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Heterodimer with ERK4/MAPK4. Interacts with (via FRIEDE motif) MAPKAPK5 (By similarity). Interacts with UBE3A; this interaction may be indirect and mediated by HERC2, possibly via HERC2 interaction with NEURL4.

    Three dimensional structures from OCA and Proteopedia for MAPK6 Gene

neXtProt entry for MAPK6 Gene

Proteomics data for MAPK6 Gene at MOPED

Post-translational modifications for MAPK6 Gene

  • Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.
  • Ubiquitination at Met-1 leads to degradation by the proteasome pathway.
  • Ubiquitination at Lys 447, Lys 471, Lys 480, Lys 517, Lys 563, Lys 631, Lys 672, Lys 691, and Lys 703
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPK6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPK6 (ERK3)

Domains & Families for MAPK6 Gene

Suggested Antigen Peptide Sequences for MAPK6 Gene

Graphical View of Domain Structure for InterPro Entry

Q16659

UniProtKB/Swiss-Prot:

MK06_HUMAN :
  • In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK6: view

Function for MAPK6 Gene

Molecular function for MAPK6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation at Ser-189.
UniProtKB/Swiss-Prot Function:
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).

Enzyme Numbers (IUBMB) for MAPK6 Gene

Gene Ontology (GO) - Molecular Function for MAPK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004707 MAP kinase activity IEA,ISS --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with MAPK6: view
genes like me logo Genes that share phenotypes with MAPK6: view

Animal Models for MAPK6 Gene

MGI Knock Outs for MAPK6:

Animal Model Products

miRNA for MAPK6 Gene

miRTarBase miRNAs that target MAPK6

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK6 Gene

Localization for MAPK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK6 Gene

Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK6 Gene COMPARTMENTS Subcellular localization image for MAPK6 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for MAPK6 Gene

Pathways & Interactions for MAPK6 Gene

genes like me logo Genes that share pathways with MAPK6: view

Pathways by source for MAPK6 Gene

SIGNOR curated interactions for MAPK6 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAPK6 Gene

None

Drugs & Compounds for MAPK6 Gene

(5) Drugs for MAPK6 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
FR 180204 Pharma ERK inhibitor, Selective ERK inhibitor 0
Magnesium Nutra 0

(1) Additional Compounds for MAPK6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for MAPK6 Gene

Compound Action Cas Number
FR 180204 ERK inhibitor 865362-74-9
genes like me logo Genes that share compounds with MAPK6: view

Transcripts for MAPK6 Gene

Unigene Clusters for MAPK6 Gene

Mitogen-activated protein kinase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for MAPK6 Gene

GeneLoc Exon Structure for
MAPK6
ECgene alternative splicing isoforms for
MAPK6

Expression for MAPK6 Gene

mRNA expression in normal human tissues for MAPK6 Gene

Protein differential expression in normal tissues from HIPED for MAPK6 Gene

This gene is overexpressed in Brain (37.6), Monocytes (18.1), and Heart (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK6 Gene



SOURCE GeneReport for Unigene cluster for MAPK6 Gene Hs.411847

mRNA Expression by UniProt/SwissProt for MAPK6 Gene

Q16659-MK06_HUMAN
Tissue specificity: Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
genes like me logo Genes that share expression patterns with MAPK6: view

Protein tissue co-expression partners for MAPK6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAPK6 Gene

Orthologs for MAPK6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPK6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPK6 35
  • 95.79 (n)
  • 97.78 (a)
MAPK6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK6 35
  • 96.35 (n)
  • 98.61 (a)
MAPK6 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk6 35
  • 88.13 (n)
  • 94.99 (a)
Mapk6 16
Mapk6 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAPK6 35
  • 99.82 (n)
  • 100 (a)
MAPK6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk6 35
  • 87.99 (n)
  • 94.16 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK6 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPK6 35
  • 87.41 (n)
  • 93.06 (a)
MAPK6 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK6 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk6 35
  • 80.57 (n)
  • 86.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23931 35
zebrafish
(Danio rerio)
Actinopterygii mapk6 35
  • 69.19 (n)
  • 76.75 (a)
mapk6 36
  • 75 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FUS3 36
  • 35 (a)
ManyToMany
KSS1 36
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7149 36
  • 22 (a)
OneToMany
Species with no ortholog for MAPK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAPK6 Gene

ENSEMBL:
Gene Tree for MAPK6 (if available)
TreeFam:
Gene Tree for MAPK6 (if available)

Paralogs for MAPK6 Gene

Paralogs for MAPK6 Gene

(9) SIMAP similar genes for MAPK6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAPK6: view

Variants for MAPK6 Gene

Sequence variations from dbSNP and Humsavar for MAPK6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs35697691 - 52,061,301(+) CAGCA(C/G)TGGAT reference, missense
rs3542 -- 52,065,355(+) TGAAA(A/G)TAGCT utr-variant-3-prime
rs11857263 -- 52,016,210(+) catgg(A/T)gaaac intron-variant
rs751560 -- 52,025,142(-) catct(C/T)agcct intron-variant
rs12101642 -- 52,004,326(+) AGCTT(C/T)TAAAA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MAPK6 Gene

Variant ID Type Subtype PubMed ID
nsv1536 CNV Loss 18451855
nsv471244 CNV Gain 18288195
esv2351837 CNV Deletion 18987734
dgv340e201 CNV Deletion 23290073
esv2749691 CNV Deletion 23290073

Variation tolerance for MAPK6 Gene

Residual Variation Intolerance Score: 9.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK6 Gene

HapMap Linkage Disequilibrium report
MAPK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK6 Gene

Disorders for MAPK6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAPK6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pulmonary immaturity
  • primary atelectasis of newborn
- elite association - COSMIC cancer census association via MalaCards
Search MAPK6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAPK6

Genetic Association Database (GAD)
MAPK6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK6
genes like me logo Genes that share disorders with MAPK6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK6 Gene

Publications for MAPK6 Gene

  1. Primary structure, expression and chromosomal locus of a human homolog of rat ERK3. (PMID: 8875998) Meloche S. … Pellerin J. (Oncogene 1996) 2 3 4 23 67
  2. Regulation of ERK3/MAPK6 expression by BRAF. (PMID: 16964379) Hoeflich K.P. … Seshagiri S. (Int. J. Oncol. 2006) 3 23
  3. N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. (PMID: 15226418) Coulombe P. … Meloche S. (Mol. Cell. Biol. 2004) 3 23
  4. Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation. (PMID: 12808096) Coulombe P. … Meloche S. (Mol. Cell. Biol. 2003) 3 23
  5. Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression. (PMID: 12915405) Julien C. … Meloche S. (J. Biol. Chem. 2003) 3 23

Products for MAPK6 Gene

Sources for MAPK6 Gene

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