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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK6 Gene

protein-coding   GIFtS: 62
GCID: GC15P052311

mitogen-activated protein kinase 6


(Previous symbol: PRKM6)
 Explore 11 diseases affiliated with
MAPK6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAPK6    

Aliases
for MAPK6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase 61 2     MAP Kinase Isoform P972 3
ERK31 2 3     MAPK 62 3
PRKM61 2 3     P97-MAPK1
HsT172501 2     EC 2.7.11.243 8
P97MAPK1     Extracellular Signal-Regulated Kinase, P972
Extracellular Signal-Regulated Kinase 32 3     Protein Kinase, Mitogen-Activated 52
ERK-32 3     Protein Kinase, Mitogen-Activated 62
MAP Kinase 62 3     EC 2.7.118

External Ids:    HGNC: 68791   Entrez Gene: 55972   Ensembl: ENSG000000699567   OMIM: 6029045   UniProtKB: Q166593   

Export aliases for MAPK6 gene to outside databases

Previous GC identifers: GC15P047869 GC15P045358 GC15P049890 GC15P050027 GC15P050098 GC15P029169


Summaries
for MAPK6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPK6:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to
mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases
(ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical
signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment
with serum or phorbol esters. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MK06_HUMAN, Q16659
Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role
of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events:
upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and
activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity)

Gene Wiki entry for MAPK6


Genomic Views
for MAPK6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK6 gene promoter:
         Egr-3   ER-alpha   NF-AT   CREB   NF-AT4   NF-AT2   Sox9   NF-AT3   ARP-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAPK6 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21

MAPK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK6 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P052311:  view genomic region     (about GC identifiers)

Start:
 52,244,303 bp from pter      End:
 52,358,462 bp from pter
Size:
 114,160 bases      Orientation:
 plus strand

Proteins
for MAPK6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MK06_HUMAN, Q16659 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 6  
Size: 721 amino acids; 82681 Da
Cofactor: Magnesium (By similarity)
Subunit: Heterodimer with ERK4/MAPK4. Interacts with (via FRIEDE motif) MAPKAPK5 (By similarity). Interacts with UBE3A;
this interaction may be indirect and mediated by HERC2, possibly via HERC2 interaction with NEURL4
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates to the cytoplasm following
interaction with MAPKAPK5 (By similarity)
1 PDB 3D structure from and Proteopedia for MAPK6:
2I6L (3D)    
Secondary accessions: Q68DH4 Q8IYN8

Explore the universe of human proteins at neXtProt for MAPK6: NX_Q16659

Post-translational modifications:

  • Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other
    • sites1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16659

    • 4/18 DME Specific Peptides for MAPK6 (Q16659) (see all 18)
     LKYIHSA  RVAIKKI  VLHRDLK  LKIGDFG 

    MAPK6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002739.1  
    ENSEMBL proteins: 
     ENSP00000261845  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAPK6 Protein
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    Novus Biologicals MAPK6 Proteins
    Novus Biologicals MAPK6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAPK6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--


    MAPK6 for ontologies           About GeneDecksing



    MAPK6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK6
    R&D Systems Antibodies for MAPK6 (ERK3)
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    Abcam antibodies for MAPK6 
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    ThermoFisher Antibody for MAPK6

    Assay Products for MAPK6: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for MAPK6
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAPK6

    Protein Domains /
    Families
    for MAPK6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPK6 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q16659

    ProtoNet protein and cluster: Q16659

    1 Blocks protein family: IPB008350 ERK3/4 MAP kinase signature

    UniProtKB/Swiss-Prot: MK06_HUMAN, Q16659
    Domain: In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose
    phosphorylation activates the MAP kinases (By similarity)
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAPK6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MK06_HUMAN, Q16659
    Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role
    of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events:
    upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and
    activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation at Ser-189

    Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK6
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK6 (see all 67):
    hsa-miR-548j hsa-miR-128 hsa-miR-374a hsa-miR-632 hsa-miR-519a hsa-miR-548a-5p hsa-miR-3148 hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK6 (see all 7)
    OriGene shRNA RFP: MAPK6
    OriGene siRNA: MAPK6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPK6

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK6 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK6

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity TAS2032290
    GO:0004707MAP kinase activity ISS--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0019901protein kinase binding IEA--


    MAPK6 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MAPK6:
     Decreased substrate adherent c  Decreased viability  Increased mitotic index 

    Animal Models:
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mapk6):
     behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism  integument 
     liver/biliary system  mortality/aging  respiratory system  skeleton 

    MAPK6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPK6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/41 super-pathways (see all 41) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ErbB4 Pathway
    8/9 pathways (see all 9)
    		ErbB4 Pathway1.00
    		Thrombopoietin Pathway0.43
    		ErbB Family Pathway0.59
    		VEGF Signaling Pathway0.35
    		Prolactin Signaling0.54
    		HMGB1 Pathway0.32
    		ErbB2-ErbB3 Heterodimers0.47
    		Growth Hormone Signaling0.32
    2GPCR Pathway
    		GPCR Pathway1.00
    		NFAT in Immune Response0.58
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    3Apoptotic Pathways in Synovial Fibroblasts
    		eIF2 Pathway0.60
    		Rap1 Pathway0.42
    		Glioma Invasiveness0.54
    4p70S6K Signaling
    		p70S6K Signaling1.00
    		mTOR Pathway0.54
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    		Neuropathic Pain-Signaling in Dorsal Horn Neurons1.00
    		Aldosterone Signaling in Epithelial Cells0.47

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK6 (see all 55)
        14-3-3 Induced Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    eIF2 Pathway
    G12-G13 in Cellular Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK6
        MAP Kinase Signaling

    2 Tocris Bioscience Pathways for MAPK6
        Insulin Pathway
    Toll-like Receptor Pathway

    5/6 BioSystems Pathways for MAPK6 (see all 6) 
        Signal Transduction of S1P Receptor
    Focal Adhesion
    MAPK signaling pathway
    Integrin-mediated cell adhesion
    Insulin Signaling

    1 PharmGKB Pathway for MAPK6
        VEGF Signaling Pathway


    MAPK6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/228 Interacting proteins for MAPK6 (Q166591, 2, 3 ENSP000002618454) via UniProtKB, MINT, STRING, and/or I2D (see all 228)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPKAPK5Q8IW412, 3, ENSP000002027884MINT-8261384 I2D: score=5 STRING: ENSP00000202788
    EIF3CQ996132, 3MINT-8261065 I2D: score=2 
    EIF3CLQ996132, 3MINT-8261065 I2D: score=2 
    NRXN2P584012, 3I2D: score=1 MINT-8261560 I2D: score=1 
    RANBP9Q96S592, 3MINT-8261835 I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0006468protein phosphorylation ISS--
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction TAS2032290


    MAPK6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPK6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK6 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK6:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAPK6

    3 HMDB Compounds for MAPK6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    2 Novoseek chemical compound relationships for MAPK6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 38.6 2 12915405 (1), 12504858 (1)
    serine 24.5 2 12915405 (1), 12504858 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK6 / MK06 

    Transcripts
    for MAPK6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPK6 gene: 
    NM_002748.3  

    Unigene Cluster for MAPK6:

    Mitogen-activated protein kinase 6
    Hs.411847  [show with all ESTs]
    Unigene Representative Sequence: NM_002748
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560802 ENST00000558063 ENST00000560254 ENST00000261845(uc002abp.3)
    ENST00000558100 ENST00000558841 ENST00000558891 ENST00000560774

    miRNA
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    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK6 (see all 67):
    hsa-miR-548j hsa-miR-128 hsa-miR-374a hsa-miR-632 hsa-miR-519a hsa-miR-548a-5p hsa-miR-3148 hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK6 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB451301.1 AF420474.1 AJ251709.1 AK313633.1 BC035492.2 CR749401.1 L77964.1 X80692.1 

    10 DOTS entries:

    DT.100017169  DT.95069177  DT.121077095  DT.121077106  DT.121077161  DT.91762974  DT.95253212  DT.100680321 
    DT.121621644  DT.99960657 

    24/264 AceView cDNA sequences (see all 264):

    BF002187 CA432548 BX474858 F12584 AI538791 CF140011 N48784 AW069490 
    AL704923 CK429196 CA411718 AA903315 AI333663 BX107742 AI696041 BG496241 
    AA426537 BF062316 CA412955 AA532540 BM479484 T32837 BG528318 BI757105 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK6    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9
    SP1:        -     -     -                                                   
    SP2:        -     -                                                         
    SP3:              -     -                                                   
    SP4:                    -                                                   


    ECgene alternative splicing isoforms for MAPK6

    Expression
    for MAPK6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPK6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAPK6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK6

    SOURCE GeneReport for Unigene cluster: Hs.411847

    UniProtKB/Swiss-Prot: MK06_HUMAN, Q16659
    Tissue specificity: Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta,
    lung, liver, pancreas, kidney and skin fibroblasts

        SABiosciences Expression via Pathway-Focused PCR Array including MAPK6: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK6

    Orthologs
    for MAPK6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MAPK6 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAPK61 mitogen-activated protein kinase 6 87.41(n)
    93.06(a)    		   415419  NM_001030549.1  NP_001025720.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPK66
    		 --
    		 91(a)
    		 1 ↔ 1
    		 GL343998.1(5273-10138)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.239312 Xenopus laevis transcribed sequence with moderate similarity more 81.91(n)    BJ060132.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mapk61 mitogen-activated protein kinase 6 69.14(n)
    76.75(a)    		   565830  NM_001045552.1  NP_001039017.1 


    ENSEMBL Gene Tree for MAPK6 (if available)
    TreeFam Gene Tree for MAPK6 (if available) 

    Paralogs
    for MAPK6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK6 gene
    MAPK42  MAPK32  MAPK72  NLK2  MAPK152  MAPK12  
    14 SIMAP similar genes for MAPK6 using alignment to 2 protein entries:     MK06_HUMAN (see all proteins):
    MAPK4    MAPK1    MAPK14    MAPK11    MAPK12    MAPK13
    CDK2    CDK6    CDK10    CDK3    CDK7    CDK4
    MAPK9    CDK9

    MAPK6 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for MAPK6 (see all 7)
    PGOHUM00000238785 PGOHUM00000248385 PGOHUM00000239050 PGOHUM00000243765 PGOHUM00000249323


    Genomic Variants
    for MAPK6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/913 NCBI SNPs in MAPK6 are shown (see all 913)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1862501221,2
    		--52309498(+) CAATGA/GTTTGG 1 -- us2k10--------
    rs1505310041,2
    		--52309605(+) AGGGTA/GGGGGA 1 -- us2k10--------
    rs20017411,2
    		--52309625(+) GTACAT/CTGATC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs757544661,2
    		F,--52310092(+) TGCGGT/CTGGAA 1 -- us2k12Minor allele frequency- C:0.02WA NA 238
    rs557147161,2
    		C,--52310118(+) TCTTGG/TTTTTT 1 -- us2k13Minor allele frequency- T:0.09WA EA 240
    rs1403092271,2
    		C,--52310167(+) GACGT-/TGTTTTA 1 -- us2k10--------
    rs783325221,2
    		C,--52310268(+) TTTCGC/GCCAGG 1 -- us2k13Minor allele frequency- G:0.09WA EA 240
    rs1165037301,2
    		F,--52310311(+) CAACCC/TCCCGC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs609159721,2
    		C,--52310423(+) CTTTC-/ACC   
      ATGTTG    GCCAT     		1 -- us2k11Minor allele frequency- ACCATGTTG:0.00NA 2
    rs750392011,2
    		C--52310423(+) CTTTCG/ACCATG 1 -- us2k12Minor allele frequency- A:0.33WA CSA 3

    HapMap Linkage Disequilibrium report for MAPK6 (52244303 - 52358462 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAPK6: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPK6
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK6

    Disorders / Diseases
    for MAPK6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPK6 for disorders           About GeneDecksing

    OMIM gene information: 602904    OMIM disorders: --

    11 diseases for MAPK6:    About MalaCards
    pulmonary immaturity    acinar cell carcinoma    oral squamous cell carcinoma    squamous cell carcinoma
    carcinoma    leukemia    colorectal cancer    glioblastoma
    breast cancer    adenocarcinoma    pancreatitis

    1 Novoseek disease relationship for MAPK6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 3 15067337 (3)


    Export disorders for MAPK6 gene to outside databases

    Publications
    for MAPK6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK6 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with MAPK6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure, expression and chromosomal locus of a human homolog of rat ERK3. (PubMed id 8875998)1, 2, 3, 9 Meloche S.... Pellerin J. (1996)
    2. Identification and proteomic analysis of distinct UBE3 A/E6AP protein complexes. (PubMed id 22645313)1, 2 Martinez-Noel G....Howley P.M. (2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3. (PubMed id 7969157)1, 2 Zhu A.X.... Flier J.S. (1994)
    5. N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. (PubMed id 15226418)1, 9 Coulombe P....Meloche S. (2004)
    6. Regulation of ERK3/MAPK6 expression by BRAF. (PubMed id 16964379)1, 9 Hoeflich K.P....Seshagiri S. (2006)
    7. Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation. (PubMed id 12808096)1, 9 Coulombe P....Meloche S. (2003)
    8. Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression. (PubMed id 12915405)1, 9 Julien C....Meloche S. (2003)
    9. Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo. (PubMed id 11741894)1, 9 Robinson M.J....Cobb M.H. (2002)
    10. Proteasome- and p38-dependent regulation of ERK3 expression. (PubMed id 11148204)1, 9 Zimmermann J....Furst P. (2001)

    External Searches for MAPK6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAPK6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5597 HGNC: 6879 AceView: MAPK6 Ensembl:ENSG00000069956 euGenes: HUgn5597
    ECgene: MAPK6 H-InvDB: MAPK6

    Other Databases showing MAPK6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAPK6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAPK6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPK6 gene:
    Search GeneIP for patents involving MAPK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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