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MAPK4 Gene

protein-coding   GIFtS: 65
GCID: GC18P048125

Mitogen-Activated Protein Kinase 4


(Previous symbol: PRKM4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 41 2     EC 2.7.11.243 8
PRKM41 2 3 5     ERK32 5
Extracellular Signal-Regulated Kinase 42 3     Erk3-related2
ERK-42 3     Erk42
MAP Kinase 42 3     p63MAPK2
MAP Kinase Isoform P632 3     ERK43
MAPK 42 3     EC 2.7.118
p63-MAPK2 3     

External Ids:    HGNC: 68781   Entrez Gene: 55962   Ensembl: ENSG000001416397   OMIM: 1769495   UniProtKB: P311523   

Export aliases for MAPK4 gene to outside databases

Previous GC identifers: GC18P048373 GC18P047974 GC18P046441 GC18P046340 GC18P044941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK4 Gene:
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase
growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where
it phosphorylates nuclear targets. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPK4 Gene:
MAPK4 (mitogen-activated protein kinase 4) is a protein-coding gene. Diseases associated with MAPK4 include pulmonary immaturity, and pancreatic cancer. GO annotations related to this gene include protein kinase binding and protein homodimerization activity. An important paralog of this gene is MAPK3.

UniProtKB/Swiss-Prot: MK04_HUMAN, P31152
Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise
role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of
phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then
mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry
in the cell cycle (By similarity)

Gene Wiki entry for MAPK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK4 gene promoter:
         HOXA9   SRF   NF-1/L   NF-1   AML1a   SRF (504 AA)   Pax-6   LCR-F1   HNF-4alpha1   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAPK4 promoter sequence
   Search Chromatin IP Primers for MAPK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

MAPK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK4 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P048125:  view genomic region     (about GC identifiers)

Start:
48,086,448 bp from pter      End:
48,258,196 bp from pter
Size:
171,749 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MK04_HUMAN, P31152 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 4  
Size: 587 amino acids; 65922 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5 (By similarity)
Sequence caution: Sequence=CAA42411.1; Type=Frameshift; Positions=Several;

Explore the universe of human proteins at neXtProt for MAPK4: NX_P31152

Explore proteomics data for MAPK4 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at
    other sites1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPK4 (P31152) (see all 14)
     GCILAEM  LKIGDFG  VLHRDLK  LKYIHSA 


    See MAPK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002738.2  
    ENSEMBL proteins: 
     ENSP00000383234   ENSP00000439231   ENSP00000466233   ENSP00000465661  

    MAPK4 Human Recombinant Protein Products:

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    OriGene Purified Protein for MAPK4
    OriGene Protein Over-expression Lysate for MAPK4
    OriGene MassSpec for MAPK4
    OriGene Custom Protein Services for MAPK4
    GenScript Custom Purified and Recombinant Proteins Services for MAPK4
    Novus Biologicals MAPK4 Protein
    Novus Biologicals MAPK4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAPK4

    MAPK4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MAPK4 (ERK4)
    OriGene Antibodies for MAPK4
    OriGene Custom Antibody Services for MAPK4
    Novus Biologicals MAPK4 Antibodies
    Abcam antibodies for MAPK4
    Cloud-Clone Corp. Antibodies for MAPK4
    ThermoFisher Antibody for MAPK4
    LSBio Antibodies in human, mouse, rat for MAPK4

    MAPK4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAPK4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAPK4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK4
    Cloud-Clone Corp. CLIAs for MAPK4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 4
    ERK subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P31152

    ProtoNet protein and cluster: P31152

    1 Blocks protein domain: IPB008350 ERK3/4 MAP kinase signature

    UniProtKB/Swiss-Prot: MK04_HUMAN, P31152
    Domain: The FRIEDE motif is required for docking MAPKAPK5 (By similarity)
    Domain: In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif,
    whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK04_HUMAN, P31152
    Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise
    role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of
    phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then
    mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry
    in the cell cycle (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation at Ser-186

         Genatlas biochemistry entry for MAPK4:
    mitogen-activated protein kinase 4 (p63),expressed in heart muscle,brain

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004707MAP kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    MAPK4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAPK4:
     Gemcitabine induced cell-death  Increased mitotic index 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK4

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPK4:
    hsa-mir-335-5p (MIRT016876)

    Block miRNA regulation of human, mouse, rat MAPK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK4 (see all 38):
    hsa-miR-106a hsa-miR-519a hsa-miR-124 hsa-miR-93 hsa-miR-3658 hsa-miR-506 hsa-miR-526b* hsa-miR-30c-2*
    SwitchGear 3'UTR luciferase reporter plasmidMAPK4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPK4
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK4

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK4 (see all 8)
    OriGene ORF clones in mouse, rat for MAPK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK4 (NM_002747)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK4
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MK04_HUMAN, P31152: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates to the cytoplasm
    following interaction with MAPKAPK5 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    MAPK4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK4 About   (see all 28)                                                                                              See pathways by source

    SuperPathContained pathways About
    1ErbB4 Pathway
    ErbB4 Pathway0.59
    HMGB1 Pathway0.36
    Prolactin Signaling0.54
    PI3K Signaling in B-Lymphocyte0.35
    Growth Hormone Signaling0.49
    2p70S6K Signaling
    p70S6K Signaling0.60
    mTOR Pathway0.54
    3EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Ephrin-Eph Signaling0.58
    4GPCR Pathway
    Breast Cancer Regulation by Stathmin10.58
    NFAT in Immune Response0.58
    5TGF-Beta Pathway
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK4 (see all 25)
        14-3-3 Induced Apoptosis
    Androgen Signaling
    Endothelin-1 Signaling Pathway
    Ephrin-Eph Signaling
    Aldosterone Signaling in Epithelial Cells

    2 Tocris Bioscience Pathways for MAPK4
        Insulin Pathway
    Toll-like Receptor Pathway

    Selected BioSystems Pathways for MAPK4 (see all 9)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Integrin-mediated cell adhesion
    Signal Transduction of S1P Receptor

    1 PharmGKB Pathway for MAPK4
        VEGF Signaling Pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAPK4
    Interactions:

        GeneGlobe Interaction Network for MAPK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK4 (P311521, 3 ENSP000003832344) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCND3P302813, ENSP000003620824I2D: score=1 STRING: ENSP00000362082
    GAB1Q134803, ENSP000002629954I2D: score=1 STRING: ENSP00000262995
    GAB2Q9UQC23I2D: score=1 
    MAPKAPK5Q8IW413I2D: score=1 
    HSP90AB1P082381EBI-3906061,EBI-352572
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS7969157
    GO:0006468protein phosphorylation TAS7969157
    GO:0007049cell cycle IEA--

    MAPK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPK4 (MK04)

    3 HMDB Compounds for MAPK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 Novoseek inferred chemical compound relationship for MAPK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 39.7 2 8662649 (1), 12504858 (1)



    MAPK4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAPK4 gene: 
    NM_002747.3  

    Unigene Cluster for MAPK4:

    Mitogen-activated protein kinase 4
    Hs.433728  [show with all ESTs]
    Unigene Representative Sequence: BC050299
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400384(uc002lev.3 uc010xdm.2 uc010doz.3) ENST00000540640
    ENST00000592595 ENST00000588540 ENST00000586735 ENST00000587823
    miRNA
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    Block miRNA regulation of human, mouse, rat MAPK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK4 (see all 38):
    hsa-miR-106a hsa-miR-519a hsa-miR-124 hsa-miR-93 hsa-miR-3658 hsa-miR-506 hsa-miR-526b* hsa-miR-30c-2*
    SwitchGear 3'UTR luciferase reporter plasmidMAPK4 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for MAPK4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK4 (NM_002747)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK4
    Primer
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    OriGene qPCR primer pairs and template standards for MAPK4
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK4
      QuantiTect SYBR Green Assays in human, mouse, rat MAPK4
      QuantiFast Probe-based Assays in human, mouse, rat MAPK4

    Additional mRNA sequence: 

    AK293818.1 AK295058.1 AK303601.1 BC040493.1 BC050299.1 BC117216.1 BC143769.1 BX648603.1 
    X59727.1 

    6 DOTS entries:

    DT.117085  DT.95223230  DT.70102859  DT.91752995  DT.95294418  DT.97772128 

    Selected AceView cDNA sequences (see all 74):

    F02578 AI088913 BM703187 AA931501 AA890356 AI168109 AI660544 N66350 
    T28761 N66376 AA868056 AI360134 AA400982 AA348840 AA771957 BM662063 
    BF953011 CF453525 AA370349 CK825007 BM700849 BM697439 BM661538 F04356 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPK4 expression in normal human tissues (normalized intensities)      MAPK4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCATTTTG
    MAPK4 Expression
    About this image


    MAPK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    MAPK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433728

    UniProtKB/Swiss-Prot: MK04_HUMAN, P31152
    Tissue specificity: High expression in heart and brain

        Custom PCR Arrays for MAPK4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK4
    QuantiTect SYBR Green Assays in human, mouse, rat MAPK4
    QuantiFast Probe-based Assays in human, mouse, rat MAPK4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAPK4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk41 , 5 mitogen-activated protein kinase 41, 5 88.05(n)1
    94.17(a)1
      18 (50.31 cM)5
    2257241  NM_172632.21  NP_766220.21 
     739284865 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK46
    mitogen-activated protein kinase 4
    81(a)
    1 ↔ 1
    GL343471.1(373626-408119)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004982021 mitogen-activated protein kinase 4-like 72.65(n)
    77.18(a)
      100498202  XM_004910358.1  XP_004910415.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044411.12   -- 78.62(n)    BC044411.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FUS36
    KSS16
    Mitogen-activated serine/threonine protein kinase ...
    Mitogen-activated protein kinase (MAPK) involved i...
    34(a)
    33(a)
    many ↔ many
    many ↔ many
    II(192451-193512) YBL016W
    VII(575398-576504) YGR040W


    ENSEMBL Gene Tree for MAPK4 (if available)
    TreeFam Gene Tree for MAPK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for MAPK4 gene
    MAPK32  MAPK72  NLK2  MAPK152  MAPK62  MAPK12  
    Selected SIMAP similar genes for MAPK4 using alignment to 6 protein entries:     MK04_HUMAN (see all proteins) (see all similar genes):
    PHKG2    MAPK6    MAPK7    CAMK1    MAPK3    DYRK4
    MAPK1    DKFZp686O0215    NEK9    MAPK14    MAPK13    MAPK9
    MOK    CDK16    STK25    MAPK11    FGFR1    MAPK12

    MAPK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPK4 (see all 3324)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs598573151,2
    C--45076412(+) AAAAA-/A/AAA 
            
    GATAG
    1 -- int11NA 2
    rs284144751,2
    C,F--48084518(+) AGCCCC/TAGACA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs169521491,2
    C,F,H--48084560(+) CGTACG/AGTAAT 1 -- us2k125Minor allele frequency- A:0.10NA NS EA WA CSA 2545
    rs560507501,2
    C,F--48084705(+) AGAGAT/GAAATT 1 -- us2k12Minor allele frequency- G:0.10WA NA 238
    rs129624471,2
    C,F,H--48084843(+) CTCTTC/TATTCG 1 -- us2k112Minor allele frequency- T:0.09NS EA NA WA CSA 669
    rs573519721,2
    C--48084903(+) TTGCC-/CTTCTG 1 -- us2k10--------
    rs169521521,2
    C,F,H--48084980(+) AAAAAT/GGAATA 1 -- us2k1 tfbs312Minor allele frequency- G:0.06NA NS EA WA CSA 663
    rs1114699601,2
    C,F--48085061(+) AGCAAG/AATGTT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1486741591,2
    --48085095(+) ACATTA/GGAATG 1 -- us2k10--------
    rs1422102801,2
    --48085168(+) CTGAGA/GTTAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPK4 (48086448 - 48258196 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MAPK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717094CNV Deletion23290073
    nsv2303CNV Insertion18451855
    nsv833651CNV Loss17160897
    esv34028CNV Loss18971310
    nsv130821CNV Loss16902084
    nsv9630CNV Loss18304495
    nsv909644CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK4
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176949    OMIM disorders: --

    9 diseases for MAPK4:    About MalaCards
    pulmonary immaturity    pancreatic cancer    tonsillitis    pancreatitis
    lung cancer    thyroiditis    breast cancer    cerebritis
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for MAPK4:
    Pulmonary immaturity

    MAPK4 for disorders           About GeneDecksing


    Export disorders for MAPK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK4 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with MAPK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. (PubMed id 21177870)1, 2 Deleris P.... Meloche S. (J. Biol. Chem. 2011)
    2. Genomic loci of human mitogen-activated protein kinases. (PubMed id 8290275)1, 3 Li L....Davis R.J. (Oncogene 1994)
    3. Heterogeneous expression of four MAP kinase isoforms in human tissues. (PubMed id 1319925)1, 2 Gonzalez F.A.... Davis R.J. (FEBS Lett. 1992)
    4. Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. (PubMed id 16973613)1, 9 Kant S....Gaestel M. (J. Biol. Chem. 2006)
    5. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. (PubMed id 18720373)1, 9 DAclAcris P....Meloche S. (J. Cell. Physiol. 2008)
    6. Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif. (PubMed id 19473979)1, 9 Aberg E....Seternes O.M. (J. Biol. Chem. 2009)
    7. Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFI+ production. (PubMed id 24020373)1 Menon M.B....Gaestel M. (Biochem. J. 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion. (PubMed id 22505454)1 Long W....O'Malley B.W. (J. Clin. Invest. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5596 HGNC: 6878 AceView: MAPK4 Ensembl:ENSG00000141639 euGenes: HUgn5596
    ECgene: MAPK4 H-InvDB: MAPK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPK4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPK4 gene:
    Search GeneIP for patents involving MAPK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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