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Aliases for MAPK4 Gene

Aliases for MAPK4 Gene

  • Mitogen-Activated Protein Kinase 4 2 3
  • PRKM4 3 4 6
  • Extracellular Signal-Regulated Kinase 4 3 4
  • MAP Kinase Isoform P63 3 4
  • EC 2.7.11.24 4 64
  • P63-MAPK 3 4
  • MAPK 4 3 4
  • ERK-4 3 4
  • ERK4 3 4
  • Erk3-Related 3
  • MAP Kinase 4 4
  • EC 2.7.11 64
  • P63MAPK 3
  • ERK3 6

External Ids for MAPK4 Gene

Previous Symbols for MAPK4 Gene

  • PRKM4

Summaries for MAPK4 Gene

Entrez Gene Summary for MAPK4 Gene

  • Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for MAPK4 Gene

MAPK4 (Mitogen-Activated Protein Kinase 4) is a Protein Coding gene. Diseases associated with MAPK4 include pulmonary immaturity. Among its related pathways are Regulation of actin cytoskeleton and TGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase binding. An important paralog of this gene is MAPK1.

UniProtKB/Swiss-Prot for MAPK4 Gene

  • Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).

Gene Wiki entry for MAPK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK4 Gene

Genomics for MAPK4 Gene

Genomic Location for MAPK4 Gene

Start:
50,560,078 bp from pter
End:
50,731,826 bp from pter
Size:
171,749 bases
Orientation:
Plus strand

Genomic View for MAPK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK4 Gene

Regulatory Elements for MAPK4 Gene

Proteins for MAPK4 Gene

  • Protein details for MAPK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31152-MK04_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 4
    Protein Accession:
    P31152
    Secondary Accessions:
    • A1A4C4
    • Q0VG04

    Protein attributes for MAPK4 Gene

    Size:
    587 amino acids
    Molecular mass:
    65922 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5 (By similarity).
    SequenceCaution:
    • Sequence=CAA42411.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for MAPK4 Gene

Proteomics data for MAPK4 Gene at MOPED

Post-translational modifications for MAPK4 Gene

  • Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK4 Gene

Domains for MAPK4 Gene

Gene Families for MAPK4 Gene

HGNC:
  • MAPK :Mitogen-activated protein kinase cascade / Kinases
IUPHAR :

UniProtKB/Swiss-Prot:

MK04_HUMAN
Domain:
  • The FRIEDE motif is required for docking MAPKAPK5.:
    • P31152
  • In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases:
    • P31152
  • Contains 1 protein kinase domain.:
    • P31152
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.:
    • P31152
genes like me logo Genes that share domains with MAPK4: view

Function for MAPK4 Gene

Molecular function for MAPK4 Gene

GENATLAS Biochemistry: mitogen-activated protein kinase 4 (p63),expressed in heart muscle,brain
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation at Ser-186
UniProtKB/Swiss-Prot Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).

Enzyme Numbers (IUBMB) for MAPK4 Gene

Gene Ontology (GO) - Molecular Function for MAPK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004707 MAP kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 22939624
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MAPK4: view

Phenotypes for MAPK4 Gene

GenomeRNAi human phenotypes for MAPK4:
genes like me logo Genes that share phenotypes with MAPK4: view

miRNA for MAPK4 Gene

miRTarBase miRNAs that target MAPK4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MAPK4 Gene

Localization for MAPK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK4 Gene

Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK4 Gene COMPARTMENTS Subcellular localization image for MAPK4 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAPK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with MAPK4: view

Pathways for MAPK4 Gene

genes like me logo Genes that share pathways with MAPK4: view

Pathways by source for MAPK4 Gene

Gene Ontology (GO) - Biological Process for MAPK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS 7969157
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with MAPK4: view

Compounds for MAPK4 Gene

(3) HMDB Compounds for MAPK4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(1) Novoseek inferred chemical compound relationships for MAPK4 Gene

Compound -log(P) Hits PubMed IDs
threonine 39.7 2
genes like me logo Genes that share compounds with MAPK4: view

Transcripts for MAPK4 Gene

Unigene Clusters for MAPK4 Gene

Mitogen-activated protein kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK4 Gene

No ASD Table

Relevant External Links for MAPK4 Gene

GeneLoc Exon Structure for
MAPK4
ECgene alternative splicing isoforms for
MAPK4

Expression for MAPK4 Gene

mRNA expression in normal human tissues for MAPK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (6.4), Brain - Caudate (basal ganglia) (6.2), and Brain - Putamen (basal ganglia) (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK4 Gene

SOURCE GeneReport for Unigene cluster for MAPK4 Gene Hs.433728

mRNA Expression by UniProt/SwissProt for MAPK4 Gene

P31152-MK04_HUMAN
Tissue specificity: High expression in heart and brain
genes like me logo Genes that share expressions with MAPK4: view

Orthologs for MAPK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK4 36
  • 99.43 (n)
  • 99.83 (a)
MAPK4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK4 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK4 36
  • 90.95 (n)
  • 93.81 (a)
MAPK4 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk4 36
  • 88.05 (n)
  • 94.17 (a)
Mapk4 16
Mapk4 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPK4 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK4 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk4 36
  • 87.42 (n)
  • 94.17 (a)
lizard
(Anolis carolinensis)
Reptilia MAPK4 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498202 36
  • 72.65 (n)
  • 77.18 (a)
zebrafish
(Danio rerio)
Actinopterygii mapk4 36
  • 65.44 (n)
  • 65.64 (a)
mapk4 37
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y106G6D.4 38
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FUS3 37
  • 34 (a)
ManyToMany
KSS1 37
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7149 37
  • 19 (a)
OneToMany
Species with no ortholog for MAPK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK4 Gene

ENSEMBL:
Gene Tree for MAPK4 (if available)
TreeFam:
Gene Tree for MAPK4 (if available)

Paralogs for MAPK4 Gene

Paralogs for MAPK4 Gene

genes like me logo Genes that share paralogs with MAPK4: view

Variants for MAPK4 Gene

Sequence variations from dbSNP and Humsavar for MAPK4 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs3288 -- 50,730,518(+) ATACT(C/T)TCCTG utr-variant-3-prime
rs8724 -- 50,731,609(+) TCTTT(A/G)AGAAA utr-variant-3-prime
rs716871 -- 50,586,350(+) AAATG(C/G)AAATT intron-variant
rs728682 -- 50,568,984(-) ctatg(C/T)tcatg intron-variant
rs736617 -- 50,590,846(+) GTAAA(G/T)CATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK4 Gene

Variant ID Type Subtype PubMed ID
esv34028 CNV Loss 18971310
nsv9630 CNV Loss 18304495
nsv833651 CNV Loss 17160897
nsv909644 CNV Gain 21882294
nsv2303 CNV Insertion 18451855
nsv130821 CNV Loss 16902084
esv2717094 CNV Deletion 23290073

Relevant External Links for MAPK4 Gene

HapMap Linkage Disequilibrium report
MAPK4

Disorders for MAPK4 Gene

(1) MalaCards Diseases for MAPK4 Gene

Search for MAPK4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for MAPK4 Gene

genes like me logo Genes that share disorders with MAPK4: view

No data available for UniProtKB/Swiss-Prot for MAPK4 Gene

Publications for MAPK4 Gene

  1. Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. (PMID: 16973613) Kant S. … Gaestel M. (J. Biol. Chem. 2006) 3 23
  2. Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. (PMID: 18720373) DAclAcris P. … Meloche S. (J. Cell. Physiol. 2008) 3 23
  3. Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif. (PMID: 19473979) Aberg E. … Seternes O.M. (J. Biol. Chem. 2009) 3 23
  4. Heterogeneous expression of four MAP kinase isoforms in human tissues. (PMID: 1319925) Gonzalez F.A. … Davis R.J. (FEBS Lett. 1992) 3 4
  5. Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. (PMID: 21177870) Deleris P. … Meloche S. (J. Biol. Chem. 2011) 3 4

Products for MAPK4 Gene

  • Addgene plasmids for MAPK4

Sources for MAPK4 Gene

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