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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAPK4 Gene

protein-coding GIFtS: 63
GCID: GC18P048125

mitogen-activated protein kinase 4

(Previous symbol: PRKM4)

Explore 2 diseases affiliated with
MAPK4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase 4¹ ²		MAPK 4² ³
PRKM4¹ ² ³ ⁵		P63-MAPK¹
Erk3-Related¹		EC 2.7.11.24³ ⁸
Erk4¹ ²		ERK3² ⁵
Extracellular Signal-Regulated Kinase 4² ³		P63MAPK¹
ERK-4² ³		ERK4³
MAP Kinase 4² ³		EC 2.7.11⁸
MAP Kinase Isoform P63² ³

External Ids:	HGNC: 6878¹	Entrez Gene: 5596²	Ensembl: ENSG00000141639⁷	OMIM: 176949⁵	UniProtKB: P31152³

Export aliases for MAPK4 gene to outside databases

Previous GC identifers: GC18P048373 GC18P047974 GC18P046441 GC18P046340 GC18P044941

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPK4:

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth

factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it

phosphorylates nuclear targets. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MK04_HUMAN, P31152

Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role

of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events:

upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and

activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity)

Gene Wiki entry for MAPK4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010966.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAPK4 gene promoter:
HOXA9 SRF NF-1/L NF-1 AML1a SRF (504 AA) Pax-6 LCR-F1 HNF-4alpha1 Msx-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAPK4 promoter sequence

Search SABiosciences Chromatin IP Primers for MAPK4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21.1

MAPK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK4 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P048125: view genomic region (about GC identifiers)

Start:	48,086,448 bp from pter	End:	48,258,196 bp from pter
Size:	171,749 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MK04_HUMAN, P31152 (See protein sequence)

Recommended Name: Mitogen-activated protein kinase 4

Size: 587 amino acids; 65922 Da

Cofactor: Magnesium (By similarity)

Subunit: Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5 (By similarity)

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates to the cytoplasm following

interaction with MAPKAPK5 (By similarity)

Sequence caution: Sequence=CAA42411.1; Type=Frameshift; Positions=Several;

Explore the universe of human proteins at neXtProt for MAPK4: NX_P31152

Post-translational modifications:

Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other

sites¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P31152

4/14 DME Specific Peptides for MAPK4 (P31152) (see all 14)

GCILAEM

LKIGDFG

VLHRDLK

LKYIHSA

MAPK4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002738.2

ENSEMBL proteins:

ENSP00000383234 ENSP00000439231 ENSP00000466233 ENSP00000465661

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant MAPK4 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MAPK4 OriGene Protein Over-expression Lysate: MAPK4 OriGene Custom Protein Services for MAPK4
	GenScript Custom Purified and Recombinant Proteins Services for MAPK4
	Novus Biologicals MAPK4 Protein Novus Biologicals MAPK4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAPK4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--

MAPK4 for ontologies About GeneDecksing

MAPK4 Antibody Products:

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	R&D Systems Antibodies for MAPK4 (ERK4)
	OriGene Antibodies (see all 3): MAPK4 OriGene Custom Antibody Services for MAPK4
	GenScript Custom Superior Antibodies Services for MAPK4
	Novus Biologicals MAPK4 Antibodies
	Search for Antibodies for MAPK4 at Abcam
	Uscn Antibodies for MAPK4
	ThermoFisher Antibody for MAPK4

Assay Products for MAPK4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MAPK4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MAPK4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAPK4 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry P31152

ProtoNet protein and cluster: P31152

1 Blocks protein family: IPB008350 ERK3/4 MAP kinase signature

UniProtKB/Swiss-Prot: MK04_HUMAN, P31152

Domain: The FRIEDE motif is required for docking MAPKAPK5 (By similarity)

Domain: In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose

phosphorylation activates the MAP kinases

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MK04_HUMAN, P31152

Function: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role

of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events:

upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and

activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated by phosphorylation at Ser-186

Genatlas biochemistry entry for MAPK4:

mitogen-activated protein kinase 4 (p63),expressed in heart muscle,brain

Enzyme Numbers (IUBMB): EC 2.7.11.24¹ ² EC 2.7.11²

miRNA Products:		OriGene 3'-UTR Clone: MAPK4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK4
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK4 (see all 38):
		hsa-miR-106a hsa-miR-519a hsa-miR-124 hsa-miR-93 hsa-miR-3658 hsa-miR-506 hsa-miR-526b* hsa-miR-30c-2*

		SwitchGear 3'UTR luciferase reporter plasmid: MAPK4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK4 (see all 4) OriGene shRNA RFP: MAPK4 OriGene siRNA: MAPK4
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MAPK4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: MAPK4 (NM_002747)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MAPK4
		Search LifeMap BioReagents cell lines for MAPK4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK4

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004707	MAP kinase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0019901	protein kinase binding	ISS	--
GO:0042803	protein homodimerization activity	ISS	--

MAPK4 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for MAPK4:

Gemcitabine induced cell-death

Increased mitotic index

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

ErbB4 Pathway

ErbB4 Pathway	1.00	HMGB1 Pathway	0.32
Prolactin Signaling	0.54	Growth Hormone Signaling	0.32
VEGF Signaling Pathway	0.35

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

p70S6K Signaling

p70S6K Signaling

1.00

mTOR Pathway

0.54

Focal Adhesion

Focal Adhesion

1.00

Integrin-mediated cell adhesion

0.38

EphB-EphrinB Signaling

EphB-EphrinB Signaling

1.00

Ephrin-Eph Signaling

0.58

Pathway sources
See GeneCards unified pathways
Show all pathways

5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK4 (see all 25)

	14-3-3 Induced Apoptosis
	Androgen Signaling
	Endothelin-1 Signaling Pathway
	Ephrin-Eph Signaling
	Aldosterone Signaling in Epithelial Cells

2 Tocris Bioscience Pathways for MAPK4

	Insulin Pathway
	Toll-like Receptor Pathway

5/10 BioSystems Pathways for MAPK4 (see all 10)

	MicroRNAs in cardiomyocyte hypertrophy
	Integrin-mediated cell adhesion
	Signal Transduction of S1P Receptor
	MAPK signaling pathway
	Focal Adhesion

1 PharmGKB Pathway for MAPK4

VEGF Signaling Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MAPK4

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/8 Interacting proteins for MAPK4 (P31152^{1, 3} ENSP00000383234⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCND3	P30281³, ENSP00000362082⁴	I2D: score=1 STRING: ENSP00000362082
MAPKAPK5	Q8IW41³, ENSP00000202788⁴	I2D: score=1 STRING: ENSP00000202788
GAB1	Q13480³, ENSP00000262995⁴	I2D: score=1 STRING: ENSP00000262995
GAB2	Q9UQC2³	I2D: score=1
HSP90AB1	P08238¹	EBI-3906061,EBI-352572

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	7969157
GO:0006468	protein phosphorylation	TAS	7969157
GO:0007049	cell cycle	IEA	--

MAPK4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MAPK4 for compounds About GeneDecksing

EMD Millipore small molecules for MAPK4:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAPK4

3 HMDB Compounds for MAPK4 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

1 Novoseek chemical compound relationship for MAPK4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	39.7	2	8662649 (1), 12504858 (1)

Search CenterWatch for drugs/clinical trials and news about MAPK4 / MK04

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAPK4 gene:

NM_002747.3

Unigene Cluster for MAPK4:

Mitogen-activated protein kinase 4

Hs.433728 [show with all ESTs]

Unigene Representative Sequence: BC050299

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000400384(uc002lev.3 uc010xdm.2 uc010doz.3) ENST00000540640

ENST00000592595 ENST00000588540 ENST00000586735 ENST00000587823

miRNA Products:		OriGene 3'-UTR Clone: MAPK4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK4
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK4 (see all 38):
		hsa-miR-106a hsa-miR-519a hsa-miR-124 hsa-miR-93 hsa-miR-3658 hsa-miR-506 hsa-miR-526b* hsa-miR-30c-2*

		SwitchGear 3'UTR luciferase reporter plasmid: MAPK4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK4 (see all 4) OriGene shRNA RFP: MAPK4 OriGene siRNA: MAPK4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK4 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MAPK4 (NM_002747)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPK4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MAPK4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK4

Additional cDNA sequence:

AK293818.1 AK295058.1 AK303601.1 BC040493.1 BC050299.1 BC117216.1 BC143769.1 BX648603.1

X59727.1

6 DOTS entries:

DT.117085 DT.95223230 DT.70102859 DT.91752995 DT.95294418 DT.97772128

24/74 AceView cDNA sequences (see all 74):

AI168109 BM697439 AA890356 BM703187 AA348840 F02578 N66350 AA771957

AA400982 AI088913 N66376 CK825007 BF953011 BM662063 T28761 CF453525

AA931501 AI660544 BM700849 BM661538 AA370349 AI360134 AA868056 AI740531

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAPK4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCATTTTG

About this image

MAPK4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MAPK4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAPK4

SOURCE GeneReport for Unigene cluster: Hs.433728

UniProtKB/Swiss-Prot: MK04_HUMAN, P31152

Tissue specificity: High expression in heart and brain

SABiosciences Custom PCR Arrays for MAPK4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPK4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MAPK4 gene from 2/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	MAPK4⁶	--	80(a)	1 ↔ 1	GL343471.1(374353-408119)
zebrafish (Danio rerio)	Actinopterygii	BC044411.1²	--	78.62(n)		BC044411.1

ENSEMBL Gene Tree for MAPK4 (if available)
TreeFam Gene Tree for MAPK4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MAPK4 gene

MAPK3² MAPK7² NLK² MAPK15² MAPK6² MAPK1²

18/48 SIMAP similar genes for MAPK4 using alignment to 6 protein entries: MK04_HUMAN (see all proteins) (see all similar genes):

PHKG2 MAPK6 MAPK7 CAMK1 MAPK3 DYRK4

DKFZp686O0215 NEK9 MAPK1 MAPK14 MAPK13 MAPK9

MOK CDK16 STK25 MAPK11 FGFR1 MAPK12

MAPK4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs57499603^1,2	C	--	44943444(+)	`AAAAA-/AAGACAC`	1	--	int¹		1		NA	2
rs28414475^1,2	F,	--	48084518(+)	`AGCCCC/TAGACA`	1	--	us2k¹		1		WA	118
rs16952149^1,2	C,F,H,	--	48084560(+)	`CGTACG/AGTAAT`	1	--	us2k¹		25		NA NS EA WA CSA	2545
rs56050750^1,2	C,F,	--	48084705(+)	`AGAGAT/GAAATT`	1	--	us2k¹		2		WA NA	238
rs12962447^1,2	C,F,H,	--	48084843(+)	`NNNNTC/TATTCG`	1	--	us2k¹		12		NS EA NA WA CSA	669
rs57351972^1,2	C,	--	48084903(+)	`TTGCC-/CTTCTG`	1	--	us2k¹		0	--	--	--	--
rs16952152^1,2	C,F,H,	--	48084980(+)	`AAAAAT/GGAATA`	1	--	us2k¹ tfbs³		12		NA NS EA WA CSA	663
rs111469960^1,2		--	48085061(+)	`AGCAAG/AATGTT`	1	--	us2k¹		1		CSA	2
rs148674159^1,2		--	48085095(+)	`ACATTA/GGAATG`	1	--	us2k¹		0	--	--	--	--
rs142210280^1,2		--	48085168(+)	`CTGAGA/GTTAAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MAPK4 (48086448 - 48258196 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MAPK4
2 CNVs: 32214 47955

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPK4

DNA2.0 Custom Variant and Variant Library Synthesis for MAPK4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAPK4 for disorders           About GeneDecksing

OMIM gene information: 176949    OMIM disorders: --

2 diseases for MAPK4:    About MalaCards

pulmonary immaturity breast cancer

1 disease from the University of Copenhagen DISEASES database for MAPK4:

Pulmonary immaturity

Export disorders for MAPK4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MAPK4 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with MAPK4)

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Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated prote in kinase 5 signaling pathway. (PubMed id 21177870)^{1, 2} DAclAcris P....Meloche S. (2011)
Genomic loci of human mitogen-activated protein kinases. (PubMed id 8290275)^{1, 3} Li L....Davis R.J. (1994)
Heterogeneous expression of four MAP kinase isoforms in human tissues. (PubMed id 1319925)^{1, 2} Gonzalez F.A.... Davis R.J. (1992)
Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. (PubMed id 16973613)^{1, 9} Kant S....Gaestel M. (2006)
Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. (PubMed id 18720373)^{1, 9} Deleris P....Meloche S. (2008)
Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ER K4 defines a novel MAPK interaction motif. (PubMed id 19473979)^{1, 9} Aberg E....Seternes O.M. (2009)
ERK3 signals through SRC-3 coactivator to promote huma n lung cancer cell invasion. (PubMed id 22505454)¹ Long W....O'Malley B.W. (2012)
Identification of the atypical MAPK Erk3 as a novel s ubstrate for p21-activated kinase (Pak) activity. (PubMed id 21317288)¹ De la Mota-Peynado A....Beeser A. (2011)
Monitoring protein-protein interactions in mammalian c ells by trans-SUMOylation. (PubMed id 21675959)¹ Srivastav R.K....Niedenthal R. (2011)
A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3. (PubMed id 18235225)¹ Hansen C.A....Jensen S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5596	HGNC: 6878	AceView: MAPK4	Ensembl:ENSG00000141639	euGenes: HUgn5596
ECgene: MAPK4	H-InvDB: MAPK4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MAPK4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MAPK4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MAPK4 gene
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Patent Information for MAPK4 gene:
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mitogen-activated protein kinase 4

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mitogen-activated protein kinase 4

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