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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK3 Gene

protein-coding   GIFtS: 76
GCID: GC16M030125

mitogen-activated protein kinase 3


(Previous symbol: PRKM3)
 Explore 154 diseases affiliated with
MAPK3 via
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Biological research products
for MAPK3    

Aliases
for MAPK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase 31 2     P44erk11
ERK11 2 3 5     P44mapk1
PRKM31 2 3 5     HS44KDAP2
Extracellular Signal-Regulated Kinase 12 3     HUMKER1A2
Insulin-Stimulated MAP2 Kinase2 3     P44ERK12
Microtubule-Associated Protein 2 Kinase2 3     P44MAPK2
ERK-12 3     Extracellular Signal-Related Kinase 12
ERT22 3     MAP Kinase 12
MAP Kinase 32 3     MAPK 12
MAP Kinase Isoform P442 3     Mitogen-Activated Protein Kinase 12
P44-ERK11     MAPK 33
P44-MAPK1     EC 2.7.118
EC 2.7.11.243 8     

External Ids:    HGNC: 68771   Entrez Gene: 55952   Ensembl: ENSG000001028827   OMIM: 6017955   UniProtKB: P273613   

Export aliases for MAPK3 gene to outside databases

Previous GC identifers: GC16P029026 GC16M030447 GC16M030123 GC16M030162 GC16M030032 GC16M027786


Summaries
for MAPK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPK3:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular
signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as
proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This
kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear
targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MK03_HUMAN, P27361
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also
in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK
cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the
regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in
initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a
number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates
are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However,
other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for
processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the
regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear
recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates
include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX,
CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or
PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2,
FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK,
MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4,
DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and
nuclear targets, thereby extending the specificity of the cascade

Gene Wiki entry for MAPK3


Genomic Views
for MAPK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK3 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAPK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

MAPK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030125:  view genomic region     (about GC identifiers)

Start:
 30,125,426 bp from pter      End:
 30,134,827 bp from pter
Size:
 9,402 bases      Orientation:
 minus strand

Proteins
for MAPK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MK03_HUMAN, P27361 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 3  
Size: 379 amino acids; 43136 Da
Cofactor: Magnesium (By similarity)
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes. Found in a complex with
at least BRAF, HRAS1, MAP2K1/MEK1, MAPK3 and RGS14 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This
interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARRB2, CANX, DAPK1 (via death domain), HSF4,
IER3, MAP2K1/MEK1, MORG1, NISCH, and SGK1. Interacts with PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding
prevents from dephosphorylation and inactivation (By similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization
1 PDB 3D structure from and Proteopedia for MAPK3:
2ZOQ (3D)    
Secondary accessions: A8CZ58 B0LPG3 Q8NHX1
Alternative splicing: 3 isoforms:  P27361-1   P27361-2   P27361-3   

Explore the universe of human proteins at neXtProt for MAPK3: NX_P27361

Post-translational modifications:

  • Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which
    • activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-2041
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P27361

    • 4/28 DME Specific Peptides for MAPK3 (P27361) (see all 28)
     LKYIHSA  RVAIKKI  GCILAEM  VLHRDLK 

    MAPK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035145.1  NP_001103361.1  NP_002737.2  

    ENSEMBL proteins: 
     ENSP00000263025   ENSP00000433746   ENSP00000432742   ENSP00000432479   ENSP00000436772  
     ENSP00000378626   ENSP00000378628   ENSP00000432292   ENSP00000378625   ENSP00000433639  
     ENSP00000327293   ENSP00000384895  
    Reactome Protein details: P27361
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAPK3 Protein
    R&D Systems Recombinant & Natural Proteins for MAPK3 (ERK1)
    Enzo Life Sciences proteins for MAPK3
    OriGene Purified Protein: MAPK3
    OriGene Protein Over-expression Lysate (see all 4): MAPK3
    OriGene Custom Protein Services for MAPK3 
    GenScript Custom Purified and Recombinant Proteins Services for MAPK3
    Novus Biologicals MAPK3 Proteins
    Novus Biologicals MAPK3 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MAPK3
    Uscn Proteins for MAPK3

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS19565474
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion TAS19565474


    MAPK3 for ontologies           About GeneDecksing



    MAPK3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK3
    R&D Systems Antibodies for MAPK3 (ERK1)
    Cell Signaling Technology (CST) Antibodies for MAPK3  (ERK1)
    OriGene Antibodies (see all 11): MAPK3
    OriGene Custom Antibody Services for MAPK3 
    GenScript Custom Superior Antibodies Services for MAPK3
    Novus Biologicals MAPK3 Antibodies
    Abcam antibodies for MAPK3 
    Uscn Antibodies for MAPK3
    ThermoFisher Antibody for MAPK3

    Assay Products for MAPK3: 
    EMD Millipore Kits and Assays for the Analysis of MAPK3
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for MAPK3 (ERK1)         (see all)
    GenScript MAPK3-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK3 (ERK1)
    Enzo Life Sciences assays for MAPK3
    Uscn ELISAs and CLIAs for MAPK3

    Protein Domains /
    Families
    for MAPK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPK3 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR003527 MAP_kinase_CS

    Graphical View of Domain Structure for InterPro Entry P27361

    ProtoNet protein and cluster: P27361

    2 Blocks protein families:
    IPB003527 MAP kinase
    IPB008349 ERK1/2 MAP kinase signature


    UniProtKB/Swiss-Prot: MK03_HUMAN, P27361
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAPK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MK03_HUMAN, P27361
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
    MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also
    in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK
    cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the
    regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in
    initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a
    number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates
    are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However,
    other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for
    processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the
    regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear
    recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates
    include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX,
    CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or
    PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2,
    FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK,
    MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4,
    DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and
    nuclear targets, thereby extending the specificity of the cascade
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-202 and Tyr-204 in response to external stimuli
    like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic
    conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates.
    Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9

         Genatlas biochemistry entry for MAPK3:
    mitogen-activated protein kinase 3 (MAP kinase) (p44),insulin activated map kinase,highly expressed in lung and in head
    and neck squamous cell carcinoma

    Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): MAPK3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK3
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK3 (see all 12):
    hsa-miR-1266 hsa-miR-206 hsa-miR-576-5p hsa-miR-4263 hsa-miR-1 hsa-miR-3672 hsa-miR-132 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK3 (see all 7)
    OriGene shRNA RFP: MAPK3
    OriGene siRNA: MAPK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPK3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MAPK3 (NM_002746)
    Sino Biological Human cDNA Clone for MAPK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAPK3
    Search LifeMap BioReagents cell lines for MAPK3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK3

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004707MAP kinase activity TAS--
    GO:0005515protein binding IPI19776015
    GO:0005524ATP binding NAS--


    MAPK3 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for MAPK3:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased telomerase activity  Decreased viability with pacli 
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for MAPK3: Mapk3tm1Gela Mapk3tm1Gpg
         12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mapk3):
     behavior/neurological  cardiovascular system  cellular  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  respiratory system 

    MAPK3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/239 super-pathways (see all 239) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_CNTF receptor signaling
    8/21 pathways (see all 21)
    		Development_CNTF receptor signaling1.00
    		Translation Regulation activity of EIF4F0.32
    		Development CNTF receptor signaling1.00
    		ErbB2/ErbB3 signaling events0.31
    		Transcription Receptor-mediated HIF regulation0.43
    		Immune response_IL-6 signaling pathway0.30
    		Transcription_Receptor-mediated HIF regulation0.43
    		Immune response IL-6 signaling pathway0.30
    2TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    3Development HGF signaling pathway
    8/17 pathways (see all 17)
    		Development HGF signaling pathway1.00
    		Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR10.24
    		Development_HGF signaling pathway0.78
    		Apoptosis and survival Anti-apoptotic action of membrane-bound ESR10.24
    		Development_Neurotrophin family signaling0.45
    		Apoptosis and survival_Role of CDK5 in neuronal death and survival0.24
    		Development Neurotrophin family signaling0.45
    		Apoptosis and survival Role of CDK5 in neuronal death and survival0.24
    4ErbB4 Pathway
    8/14 pathways (see all 14)
    		ErbB4 Pathway1.00
    		LPS Stimulated MAPK Signaling0.36
    		ErbB Family Pathway0.59
    		VEGF Signaling Pathway0.35
    		Prolactin Signaling0.54
    		TREM1 Pathway0.32
    		ErbB2-ErbB3 Heterodimers0.47
    		HMGB1 Pathway0.32
    5IL-9 Signaling Pathways
    8/14 pathways (see all 14)
    		IL-9 Signaling Pathways1.00
    		IL-9 Signaling Pathway0.42
    		IL-21 Signaling Pathways0.90
    		Immune response_IL-9 signaling pathway0.42
    		IL-7 Signaling Pathways0.90
    		Immune response IL-9 signaling pathway0.42
    		Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    		IL-7 Signaling Pathway0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/81 EMD Millipore Pathways for MAPK3 (see all 81)
        Chemotaxis CXCR4 signaling pathway
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling FAK signaling
    Immune response MIF-mediated glucocorticoid regulation

    5/9 R&D Systems Pathways for MAPK3 (see all 9)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways

    5/134 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK3 (see all 134)
        Molecular Mechanisms of Cancer
    eIF2 Pathway
    CDK5 Pathway
    NF-kappaB Activation by Viruses
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK3
        MAP Kinase Signaling

    5/6 Tocris Bioscience Pathways for MAPK3 (see all 6)
        Insulin Pathway
    Toll-like Receptor Pathway
    TGF-beta Pathway
    VEGF Pathway
    MAPK Pathway

    5/86 GeneGo (Thomson Reuters) Pathways for MAPK3 (see all 86)
        Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Immune response IL-9 signaling pathway

    5/89 BioSystems Pathways for MAPK3 (see all 89) 
        MicroRNAs in cardiomyocyte hypertrophy
    MAPK signaling pathway
    Serotonin Receptor 4/6/7 and NR3C Signaling
    Apoptosis Modulation and Signaling
    Oncostatin M Signaling Pathway

    5/107        Reactome Pathways for MAPK3 (see all 107)
        Toll Like Receptor 2 (TLR2) Cascade
    SHC-related events
    Toll Like Receptor TLR6:TLR2 Cascade
    Signal transduction by L1
    RNA Polymerase I Transcription

    5/7 PharmGKB Pathways for MAPK3 (see all 7)
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Diuretics Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics

    5/56         Kegg Pathways  (Kegg details for MAPK3) (see all 56):
        MAPK signaling pathway
    ErbB signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    mTOR signaling pathway


    MAPK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/540 Interacting proteins for MAPK3 (P273611, 2, 3 ENSP000002630254) via UniProtKB, MINT, STRING, and/or I2D (see all 540)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DUSP1P285622, 3, ENSP000002392234MINT-8217037 MINT-8291563 MINT-8291543 MINT-8238422 MINT-8288630 I2D: score=5 STRING: ENSP00000239223
    PPP2CAP677752, 3, ENSP000004184474MINT-8216525 MINT-8216535 I2D: score=4 STRING: ENSP00000418447
    DUSP6Q168282, 3, ENSP000002794884MINT-8216553 I2D: score=5 STRING: ENSP00000279488
    BTBD10Q9BSF82, 3, ENSP000002781744MINT-8260559 I2D: score=2 STRING: ENSP00000278174
    CASP8Q147902, 3, ENSP000003512734MINT-4329823 I2D: score=2 STRING: ENSP00000351273
    About this table

    Gene Ontology (GO): 5/58 biological process terms (GO ID links to tree view) (see all 58):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--
    GO:0000187activation of MAPK activity TAS--
    GO:0001934positive regulation of protein phosphorylation IMP19664780
    GO:0002224toll-like receptor signaling pathway TAS--


    MAPK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK3 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK3:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for MAPK3

    Browse Tocris compounds for MAPK3

    3 HMDB Compounds for MAPK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--
    SumatriptanImigran (see all 4)103628-46-2--

    4 DrugBank Compounds for MAPK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arsenic trioxideAcide Arsenieux [French] (see all 11)1327-53-3targetinducer12472888 14516795 15849723 14674888 17158527
    Sulindac-- 38194-50-2targetinhibitor11245463 12566304 16138927 15548677 16546990
    5-iodotubercidin-- 24386-93-4target--10592235
    Purvalanol-- --targetinhibitor11752352

    10/135 Novoseek chemical compound relationships for MAPK3 gene (see all 135)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 98,059 88.5 56 10234573 (2), 11483613 (2), 9159118 (1), 10037749 (1) (see all 50)
    tyrosine 76.2 153 9144515 (4), 9372245 (4), 10207014 (3), 11695994 (3) (see all 99)
    wortmannin 69 16 10698349 (1), 11994364 (1), 15563584 (1), 9531494 (1) (see all 13)
    phosphatidylinositol 69 29 15971170 (1), 10485875 (1), 15591621 (1), 15705788 (1) (see all 27)
    sb 203580 68.4 5 15971170 (1), 18288130 (1), 11910351 (1), 17054427 (1) (see all 5)
    pd-184352 65.5 3 14566055 (1), 15381709 (1)
    ly294002 64.8 15 11483613 (2), 15971170 (1), 15563584 (1), 11422447 (1) (see all 14)
    threonine 62 33 9254052 (2), 1540184 (1), 8631872 (1), 18433299 (1) (see all 27)
    ag 1478 61.5 2 12922939 (1), 10702246 (1)
    c5b-6 61.3 2 9476129 (1), 9127005 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK3 / MK03 

    Transcripts
    for MAPK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPK3 gene (3 alternative transcripts): 
    NM_001040056.1  NM_001109891.1  NM_002746.2  

    Unigene Cluster for MAPK3:

    Mitogen-activated protein kinase 3
    Hs.861  [show with all ESTs]
    Unigene Representative Sequence: BX537897
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263025 ENST00000466521 ENST00000484663(uc002dwr.3) ENST00000490298
    ENST00000485579 ENST00000461737 ENST00000494643 ENST00000473431 ENST00000395200
    ENST00000395202 ENST00000478356 ENST00000395199 ENST00000483869 ENST00000481230
    ENST00000322266(uc002dwv.4) ENST00000403394(uc002dws.3 uc002dwt.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): MAPK3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK3
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK3 (see all 12):
    hsa-miR-1266 hsa-miR-206 hsa-miR-576-5p hsa-miR-4263 hsa-miR-1 hsa-miR-3672 hsa-miR-132 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK3 (see all 7)
    OriGene shRNA RFP: MAPK3
    OriGene siRNA: MAPK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MAPK3 (NM_002746)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK3

    Additional cDNA sequence: 

    AK091009.1 AK307995.1 AY033607.1 AY033608.1 BC000205.1 BC013992.1 BX537897.1 DQ399291.1 
    M84490.1 X60188.1 Z11696.1 

    21 DOTS entries:

    DT.95267053  DT.100815232  DT.100815233  DT.102841994  DT.102841556  DT.120695495  DT.100038547  DT.120695060 
    DT.455934  DT.102842054  DT.92445473  DT.100711431  DT.100720885  DT.100815228  DT.100815231  DT.100815235 
    DT.100714917  DT.100815222  DT.100815225  DT.91787971  DT.95267057 

    24/477 AceView cDNA sequences (see all 477):

    AA351798 AI889567 AA357613 AA454819 BM701071 BM666645 AL515713 BX445446 
    BG163533 BQ066864 BQ890149 BU608224 BC002714 AL558763 AK026256 CR597147 
    CD515261 CA397310 BE700056 BG386083 AW138059 AA295845 CD519005 CA313705 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
    SP1:                          -     -     -                             -                                         -                     
    SP2:                                                                    -                                         -                     
    SP3:                          -     -     -                             -           -                                                   
    SP4:                          -     -     -                 -     -     -           -                             -                     
    SP5:                                      -                       -     -                                                               


    ECgene alternative splicing isoforms for MAPK3

    Expression
    for MAPK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGCCCCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPK3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbAutopod Synovial JointCentral Intermediate Lamina CellsCartilage
    LimbStylopod Synovial JointCentral Intermediate Lamina CellsCartilage
    LimbZeugopod Synovial JointCentral Intermediate Lamina CellsCartilage
    OvaryAntral FollicleCumulus CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAPK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK3

    SOURCE GeneReport for Unigene cluster: Hs.861
        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK3 (see all 16): 
              mTOR Signaling in human mouse rat
              Antiviral Response in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for MAPK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK3 gene from 7/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia MAPK36
    		 --
    		 86(a)
    		 1 ↔ 1
    		 GL343279.1(416338-421979)
    zebrafish
    (Danio rerio)    		 Actinopterygii AB030902.12   -- 79.44(n)    AB030902.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG187323   -- 87(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea mpk-13 serine/threonine kinase (CDC2/CDC28
    subfamily)    		 77(a)
    (best of 8)    		   III(4289194-4299892)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes FUS31 Fus3p 56.38(n)
    52.52(a)    		   852265   NP_009537.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MPK21 mitogen-activated protein kinase 2 55.62(n)
    50.45(a)    		   842248  NM_202320.1  NP_974049.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.4062 Oryza sativa mRNA for MAPK2 protein (mapk2 gene) 77.09(n)    AJ250311.1 


    ENSEMBL Gene Tree for MAPK3 (if available)
    TreeFam Gene Tree for MAPK3 (if available) 

    Paralogs
    for MAPK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK3 gene
    MAPK42  MAPK72  NLK2  MAPK152  MAPK62  MAPK12  
    18/84 SIMAP similar genes for MAPK3 using alignment to 10 protein entries:     MK03_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O0215    MAPK1    MAP3K3    DYRK4    MAPK7    MAPK14
    MAPK11    MAPK4    MAPK13    MAPK8    MAP4K1    NEK8
    PHKG2    MAPK15    TLK2    NLK    AKT2    DKFZp686M02159

    MAPK3 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/204 NCBI SNPs in MAPK3 are shown (see all 204)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs118652281,2
    		C,F,H,--27786791(+) TGAATG/AAGATG 3 -- ut313Minor allele frequency- A:0.04NS NA 98
    rs10424041,2
    		A--27786793(-) CTCATC/TTCATT 3 -- ut313Minor allele frequency- T:0.00MN NA 188
    rs76981,2
    		C,F,A,H,--27786931(-) TGCTGC/TGCCCT 3 -- ut31 ese313Minor allele frequency- T:0.20MN NS EA NA WA 1336
    rs37518671,2
    		C--27786983(-) CCCACA/GGGGCC 3 -- ut310--------
    rs412808601,2
    		C--27786988(+) CGTGGA/GGAGGG 3 -- ut310--------
    rs784215491,2
    		F,--27787178(+) GCAGGC/AAGAAG 3 -- int11Minor allele frequency- A:0.02WA 118
    rs617642241,2
    		C,F,--27787964(-) CAGCGC/GCCAGC 3 -- int15Minor allele frequency- G:0.07NS WA 212
    rs617642231,2
    		C,F,--27788446(-) TGGATC/TACAAG 3 -- int13Minor allele frequency- T:0.02NS WA 92
    rs617642221,2
    		C,F,--27788773(-) GGTCAC/TTCTGG 3 -- int13Minor allele frequency- T:0.04NS WA 212
    rs617642211,2
    		C,F,--27788917(-) TGGCTC/TATGCC 3 -- int12Minor allele frequency- T:0.02NS 94

    HapMap Linkage Disequilibrium report for MAPK3 (30125426 - 30134827 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for MAPK3
         4 CNVs: 4940 35383 4001 35384
    Human Gene Mutation Database (HGMD): MAPK3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPK3
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK3

    Disorders / Diseases
    for MAPK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPK3 for disorders           About GeneDecksing

    OMIM gene information: 601795    OMIM disorders: --

    20/154 diseases for MAPK3 (see all 154):    About MalaCards
    estrogen-receptor negative breast cancer    neurodegeneration    diffuse large b-cell lymphoma    cervical intraepithelial neoplasia
    retinol binding protein    supranuclear palsy    squamous cell carcinoma    progressive supranuclear palsy
    b-cell lymphomas    malignant pleural mesothelioma    familial medullary thyroid carcinoma    primitive neuroectodermal tumor
    severe acute respiratory syndrome    corticobasal degeneration    intractable epilepsy    barrett's esophagus
    laryngeal squamous cell carcinoma    neuroectodermal tumors    pleomorphic rhabdomyosarcoma    klebsiella

    2 diseases from the University of Copenhagen DISEASES database for MAPK3:
    Cancer     Vascular disease

    10/59 Novoseek disease relationships for MAPK3 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 37.9 52 15854513 (2), 14749472 (2), 9223425 (2), 16138005 (2) (see all 39)
    breast cancer 33.5 24 15928662 (2), 11464287 (1), 11933076 (1), 10481052 (1) (see all 20)
    necrosis 31.7 11 16641451 (1), 16489115 (1), 12183057 (1), 15240747 (1) (see all 10)
    colon carcinoma 27.3 2 15735687 (1), 18533112 (1)
    glioblastoma 26.4 5 12165859 (1), 16012865 (1), 11115541 (1), 11234878 (1) (see all 5)
    cancer 25.8 6 8635462 (1), 15826073 (1), 15655810 (1), 18951930 (1) (see all 6)
    leukemia 21.6 4 19363496 (1), 15826073 (1), 11372759 (1)
    carcinoma squamous cell 20.7 13 11520272 (3), 18004471 (2), 1939237 (1), 18472963 (1) (see all 8)
    shock 16.9 14 15364926 (2), 11463862 (1), 17113785 (1), 8940068 (1) (see all 10)
    retinoblastoma 13.7 1 19665013 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAPK3 (8 documents)

    Export disorders for MAPK3 gene to outside databases

    Publications
    for MAPK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK3 gene, integrated from 9 sources (see all 1844):
    (articles sorted by number of sources associating them with MAPK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PubMed id 10224087)1, 2, 9 Todd J.L....Denu J.M. (1999)
    2. Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1. (PubMed id 7687743)1, 2, 9 Charest D.L.... Mordret G. (1993)
    3. Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs. (PubMed id 1540184)1, 2, 9 Owaki H.... Geppert T.D. (1992)
    4. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. (PubMed id 9155018)1, 2, 9 Fukunaga R. and Hunter T. (1997)
    5. Heterogeneous expression of four MAP kinase isoforms in human tissues. (PubMed id 1319925)1, 2, 9 Gonzalez F.A.... Davis R.J. (1992)
    6. The ERK signaling cascade--views from different subcellular compartments. (PubMed id 19565474)1, 2 Yao Z. and Seger R. (2009)
    7. A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. (PubMed id 19060905)1, 2 Lorenz K....Lohse M.J. (2009)
    8. Protein kinase SGK1 enhances MEK/ERK complex formatio n through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration. (PubMed id 19447520)1, 2 Won M....Hur G.M. (2009)
    9. Tumor suppressor density-enhanced phosphatase-1 (DEP- 1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. (PubMed id 19494114)1, 2 Sacco F....Cesareni G. (2009)
    10. Crystal structure of human mono-phosphorylated ERK1 at Tyr204. (PubMed id 18983981)1, 2 Kinoshita T....Tada T. (2008)

    External Searches for MAPK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAPK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5595 HGNC: 6877 AceView: MAPK3andMGC4171 Ensembl:ENSG00000102882 euGenes: HUgn5595
    ECgene: MAPK3 Kegg: 5595 H-InvDB: MAPK3

    Other Databases showing MAPK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAPK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAPK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPK3 gene:
    Search GeneIP for patents involving MAPK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MAPK3 gene

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    Advanced Cell Diagnostics
    About This Section

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