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MAPK3 Gene

protein-coding   GIFtS: 77
GCID: GC16M030125

Mitogen-Activated Protein Kinase 3


(Previous symbol: PRKM3)
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Aliases
for MAPK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 31 2     EC 2.7.11.243 8
PRKM31 2 3 5     HS44KDAP2
ERK12 3 5     HUMKER1A2
Extracellular Signal-Regulated Kinase 12 3     P44ERK12
Insulin-Stimulated MAP2 Kinase2 3     P44MAPK2
Microtubule-Associated Protein 2 Kinase2 3     Extracellular Signal-Related Kinase 12
ERK-12 3     MAPK 12
ERT22 3     MAP Kinase 33
MAP Kinase Isoform P442 3     MAPK 33
p44-ERK12 3     EC 2.7.118
p44-MAPK2 3     

External Ids:    HGNC: 68771   Entrez Gene: 55952   Ensembl: ENSG000001028827   OMIM: 6017955   UniProtKB: P273613   

Export aliases for MAPK3 gene to outside databases

Previous GC identifers: GC16P029026 GC16M030447 GC16M030123 GC16M030162 GC16M030032 GC16M027786


Summaries
for MAPK3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK3 Gene:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular
signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as
proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals.
This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it
phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms
have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPK3 Gene:
MAPK3 (mitogen-activated protein kinase 3) is a protein-coding gene. Diseases associated with MAPK3 include pleomorphic rhabdomyosarcoma, and familial medullary thyroid carcinoma. GO annotations related to this gene include phosphatase binding and MAP kinase activity. An important paralog of this gene is MAPK4.

UniProtKB/Swiss-Prot: MK03_HUMAN, P27361
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They
participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular
context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and
differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK
cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in
differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been
discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the
regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in
other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis.
Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome
processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the
fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2,
BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or
STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation
(such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein
kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,
RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are
other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets,
thereby extending the specificity of the cascade

summary for MAPK3 Gene:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK3 Gene


Genomic Views
for MAPK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK3 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAPK3 promoter sequence
   Search Chromatin IP Primers for MAPK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

MAPK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030125:  view genomic region     (about GC identifiers)

Start:
 30,125,426 bp from pter      End:
 30,134,827 bp from pter
Size:
 9,402 bases      Orientation:
 minus strand

Proteins
for MAPK3 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MK03_HUMAN, P27361 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 3  
Size: 379 amino acids; 43136 Da
Cofactor: Magnesium (By similarity)
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes. Found in a complex
with at least BRAF, HRAS, MAP2K1/MEK1, MAPK3 and RGS14 (By similarity). Binds to HIV-1 Nef through its SH3
domain. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARRB2, CANX, DAPK1 (via
death domain), HSF4, IER3, MAP2K1/MEK1, MORG1, NISCH, and SGK1. Interacts with PEA15 and MKNK2 (By similarity).
MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with TPR
1 PDB 3D structure from and Proteopedia for MAPK3:
2ZOQ (3D)    
Secondary accessions: A8CZ58 B0LPG3 Q8NHX1
Alternative splicing: 3 isoforms:  P27361-1   P27361-2   P27361-3   

Explore the universe of human proteins at neXtProt for MAPK3: NX_P27361

Explore proteomics data for MAPK3 at MOPED

Post-translational modifications: 

  • Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which
    activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-2041
  • Ubiquitination2 at Lys72, Lys220, Lys317
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for MAPK3 (P27361) (see all 28)
     LKYIHSA  RVAIKKI  GCILAEM  VLHRDLK 


    See MAPK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035145.1  NP_001103361.1  NP_002737.2  

    ENSEMBL proteins: 
     ENSP00000263025   ENSP00000433746   ENSP00000432742   ENSP00000432479   ENSP00000436772  
     ENSP00000378626   ENSP00000378628   ENSP00000432292   ENSP00000378625   ENSP00000433639  
     ENSP00000327293   ENSP00000384895  
    Reactome Protein details: P27361

    MAPK3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for MAPK3 (ERK1)
    Enzo Life Sciences proteins for MAPK3
    OriGene Purified Protein for MAPK3
    OriGene Protein Over-expression Lysate for MAPK3
    OriGene MassSpec for MAPK3
    OriGene Custom Protein Services for MAPK3
    GenScript Custom Purified and Recombinant Proteins Services for MAPK3
    Novus Biologicals MAPK3 Proteins
    Novus Biologicals MAPK3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAPK3
    Browse Proteins at Cloud-Clone Corp.

    MAPK3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK3
    R&D Systems Antibodies for MAPK3 (ERK1)
    Cell Signaling Technology (CST) Antibodies for MAPK3  (ERK1)
    OriGene Antibodies for MAPK3
    OriGene Custom Antibody Services for MAPK3
    Novus Biologicals MAPK3 Antibodies
    Abcam antibodies for MAPK3 (P27361, P28482)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for MAPK3
    LSBio Antibodies in human, mouse, rat for MAPK3

    MAPK3 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of MAPK3
    OriGene Custom Assay Services for MAPK3
    R&D Systems ELISAs for MAPK3 (ERK1)         (see all)
    GenScript Custom Assay Services for MAPK3
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK3 (ERK1)
    Enzo Life Sciences assays for MAPK3
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.

    Domains /
    Families
    for MAPK3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 3
    ERK subfamily
    Mitogen-activated protein kinases

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR003527 MAP_kinase_CS

    Graphical View of Domain Structure for InterPro Entry P27361

    ProtoNet protein and cluster: P27361

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008349 ERK1/2 MAP kinase signature


    UniProtKB/Swiss-Prot: MK03_HUMAN, P27361
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK3 for domains           About GeneDecksing


    Function
    for MAPK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK03_HUMAN, P27361
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They
    participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular
    context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and
    differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK
    cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in
    differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been
    discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the
    regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in
    other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis.
    Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome
    processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the
    fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2,
    BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or
    STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation
    (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein
    kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,
    RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are
    other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets,
    thereby extending the specificity of the cascade
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-202 and Tyr-204 in response to external
    stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes
    dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates.
    Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9

         Genatlas biochemistry entry for MAPK3:
    mitogen-activated protein kinase 3 (MAP kinase) (p44),insulin activated map kinase,highly expressed in lung and in
    head and neck squamous cell carcinoma

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004707MAP kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10066421
         
    MAPK3 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAPK3:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased telomerase activity  Decreased viability with pacli 
     Increased gamma-H2AX phosphory 

         14 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mapk3):
     behavior/neurological  cardiovascular system  cellular  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  nervous system  respiratory system  tumorigenesis 

    MAPK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAPK3: Mapk3tm1Gela Mapk3tm1Gpg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK3

    miRNA
    Products:            		miRTarBase miRNAs that target MAPK3:
    hsa-mir-483-5p (MIRT006217), hsa-mir-320b (MIRT036229), hsa-mir-423-3p (MIRT042561), hsa-mir-34a-5p (MIRT047369)

    Block miRNA regulation of human, mouse, rat MAPK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK3 (see all 12):
    hsa-miR-1266 hsa-miR-206 hsa-miR-576-5p hsa-miR-4263 hsa-miR-1 hsa-miR-3672 hsa-miR-132 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK3 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for MAPK3
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPK3

    Clone
    Products:             		 OriGene clones in human, mouse for MAPK3 (see all 18)
    OriGene ORF clones in mouse, rat for MAPK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAPK3 (NM_002746)
    Sino Biological Human cDNA Clone for MAPK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK3

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAPK3
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK3 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK3


    Localization
    for MAPK3 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    MK03_HUMAN, P27361: Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endosome5
    golgi apparatus5
    mitochondrion5
    nucleus5
    plasma membrane5
    cytoskeleton4
    extracellular2
    endoplasmic reticulum1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS19565474
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion TAS19565474

    MAPK3 for ontologies           About GeneDecksing


    Pathways & Interactions
    for MAPK3 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK3 About   (see all 235)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    		Immune response Fc epsilon RI pathway0.43
    		VEGF signaling pathway0.39
    		Immune response BCR pathway0.43
    		VEGF - VEGF R2 Signaling Pathways0.35
    		Fc epsilon RI signaling pathway0.41
    		Fc-epsilon receptor I signaling in mast cells0.34
    2IL-9 Signaling Pathways
    		IL-9 Signaling Pathways0.90
    		IL-4 Signaling Pathways0.84
    		IL-7 Signaling Pathways0.90
    		IL-9 Signaling Pathway0.42
    		IL-21 Signaling Pathways0.90
    		Immune response IL 9 signaling pathway0.42
    		Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    		IL-7 Signaling Pathway0.40
    3Translation Insulin regulation of translation
    		Translation Insulin regulation of translation0.59
    		Cell adhesion PLAU signaling0.35
    		Regulation of lipid metabolism Insulin signaling generic cascades0.59
    		Transcription PPAR Pathway0.34
    		Transcription Receptor mediated HIF regulation0.51
    		mTOR signaling pathway0.34
    		Translation Regulation activity of EIF20.47
    		Insulin signaling pathway0.32
    4Development HGF signaling pathway
    		Development HGF signaling pathway0.45
    		Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    		Development Neurotrophin family signaling0.45
    		Neurotrophin signaling pathway0.36
    		Development EGFR signaling via small GTPases0.44
    		Signaling of Hepatocyte Growth Factor Receptor0.35
    		Development PDGF signaling via MAPK cascades0.41
    		Apoptosis and survival Anti apoptotic action of membrane bound ESR10.35
    5G protein signaling Ras family GTPases in kinase cascades scheme
    		G protein signaling Ras family GTPases in kinase cascades scheme 0.44
    		Oncostatin M Signaling Pathway0.37
    		MAPK Cascade0.44
    		Activation of the AP-1 family of transcription factors0.00
    		Immune response Oncostatin M signaling via MAPK in human cells0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for MAPK3 (see all 14)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-17 Family Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK3 (see all 134)
        Molecular Mechanisms of Cancer
    eIF2 Pathway
    CDK5 Pathway
    NF-kappaB Activation by Viruses
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK3
        MAP Kinase Signaling

    Selected Tocris Bioscience Pathways for MAPK3 (see all 6)
        Insulin Pathway
    Toll-like Receptor Pathway
    TGF-beta Pathway
    VEGF Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MAPK3 (see all 86)
        Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Immune response IL-9 signaling pathway

    Selected BioSystems Pathways for MAPK3 (see all 94)
        Osteopontin Signaling
    MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Signal Transduction of S1P Receptor
    Hypothetical Network for Drug Addiction

    3 Sino Biological Pathways for MAPK3
        TNF Signaling
    EGFR Signaling Pathway
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for MAPK3 (see all 21)
        Advanced glycosylation endproduct receptor signaling
    Regulation of HSF1-mediated heat shock response
    FCERI mediated MAPK activation
    Negative regulation of FGFR signaling
    Signal transduction by L1

    Selected PharmGKB Pathways for MAPK3 (see all 7)
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Diuretics Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for MAPK3) (see all 75):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway


    MAPK3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK3 (see all 16): 
              mTOR Signaling in human mouse rat
              Antiviral Response in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK3 (P273611, 2, 3 ENSP000002630254) via UniProtKB, MINT, STRING, and/or I2D (see all 856)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=1 STRING: ENSP00000406359
    ENSG00000235941P081073, ENSP000004045244I2D: score=1 STRING: ENSP00000404524
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 65):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--
    GO:0000187activation of MAPK activity TAS--
    GO:0001934positive regulation of protein phosphorylation IMP19664780
    GO:0002224toll-like receptor signaling pathway TAS--

    MAPK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MAPK3
      Browse compounds at ApexBio 

    Compounds for MAPK3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    XMD 8-92Selective ERK5/BMK1 inhibitor[1234480-50-2]
    FR 180204Selective ERK inhibitor[865362-74-9]
    PluripotinDual ERK1/RasGAP inhibitor. Maintains ESC self-renewal[839707-37-8]
    TCS ERK 11ePotent and selective ERK2 inhibitor[896720-20-0]

    3 HMDB Compounds for MAPK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--
    SumatriptanImigran (see all 4)103628-46-2--

    4 DrugBank Compounds for MAPK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arsenic trioxideAcide Arsenieux [French] (see all 11)1327-53-3targetinducer12472888 14516795 15849723 14674888 17158527
    Sulindac-- 38194-50-2targetinhibitor11245463 12566304 16138927 15548677 16546990
    5-iodotubercidin-- 24386-93-4target--10592235
    Purvalanol-- --targetinhibitor11752352

    Selected Novoseek inferred chemical compound relationships for MAPK3 gene (see all 135)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 98,059 88.5 56 10234573 (2), 11483613 (2), 9159118 (1), 10037749 (1) (see all 50)
    tyrosine 76.2 153 9144515 (4), 9372245 (4), 10207014 (3), 11695994 (3) (see all 99)
    wortmannin 69 16 10698349 (1), 11994364 (1), 15563584 (1), 9531494 (1) (see all 13)
    phosphatidylinositol 69 29 15971170 (1), 10485875 (1), 15591621 (1), 15705788 (1) (see all 27)
    sb 203580 68.4 5 15971170 (1), 18288130 (1), 11910351 (1), 17054427 (1) (see all 5)
    pd-184352 65.5 3 14566055 (1), 15381709 (1)
    ly294002 64.8 15 11483613 (2), 15971170 (1), 15563584 (1), 11422447 (1) (see all 14)
    threonine 62 33 9254052 (2), 1540184 (1), 8631872 (1), 18433299 (1) (see all 27)
    ag 1478 61.5 2 12922939 (1), 10702246 (1)
    c5b-6 61.3 2 9476129 (1), 9127005 (1)



    MAPK3 for compounds           About GeneDecksing



    Transcripts
    for MAPK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for MAPK3 gene (3 alternative transcripts): 
    NM_001040056.2  NM_001109891.1  NM_002746.2  

    Unigene Cluster for MAPK3:

    Mitogen-activated protein kinase 3
    Hs.861  [show with all ESTs]
    Unigene Representative Sequence: BX537897
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263025 ENST00000466521 ENST00000484663(uc002dwr.3) ENST00000490298
    ENST00000485579 ENST00000461737 ENST00000494643 ENST00000473431 ENST00000395200
    ENST00000395202 ENST00000478356 ENST00000395199 ENST00000483869 ENST00000481230
    ENST00000322266(uc002dwv.4) ENST00000403394(uc002dws.3 uc002dwt.3)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat MAPK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK3 (see all 12):
    hsa-miR-1266 hsa-miR-206 hsa-miR-576-5p hsa-miR-4263 hsa-miR-1 hsa-miR-3672 hsa-miR-132 hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAPK3
    Clone
    Products:             		 OriGene clones in human, mouse for MAPK3 (see all 18)
    OriGene ORF clones in mouse, rat for MAPK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAPK3 (NM_002746)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK3
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for MAPK3
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK3
      QuantiTect SYBR Green Assays in human, mouse, rat MAPK3
      QuantiFast Probe-based Assays in human, mouse, rat MAPK3

    Additional mRNA sequence: 

    AK091009.1 AK307995.1 AY033607.1 AY033608.1 BC000205.1 BC013992.1 BX537897.1 DQ399291.1 
    M84490.1 X60188.1 Z11696.1 

    21 DOTS entries:

    DT.95267053  DT.100815232  DT.100815233  DT.102841994  DT.102841556  DT.120695495  DT.100038547  DT.120695060 
    DT.455934  DT.102842054  DT.92445473  DT.100711431  DT.100720885  DT.100815228  DT.100815231  DT.100815235 
    DT.100714917  DT.100815222  DT.100815225  DT.91787971  DT.95267057 

    Selected AceView cDNA sequences (see all 477):

    BU740487 BQ030332 N91818 BU629086 BM703025 BI771684 BM041252 BU734399 
    BI829198 BI767377 CK430615 CR607536 H80909 BC002714 BQ639471 BQ068307 
    BU736402 BU729142 CR603463 BU726951 BC000205 BM666645 AA359549 BF115305 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPK3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
    SP1:                          -     -     -                             -                                         -                     
    SP2:                                                                    -                                         -                     
    SP3:                          -     -     -                             -           -                                                   
    SP4:                          -     -     -                 -     -     -           -                             -                     
    SP5:                                      -                       -     -                                                               


    ECgene alternative splicing isoforms for MAPK3

    Expression
    for MAPK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAPK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCCCCCC
    MAPK3 Expression
    About this image


    MAPK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Smooth Muscle (Muscoskeletal System)
             Contractile smooth muscle-like cells
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    MAPK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    MAPK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.861
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK3 (see all 16): 
              mTOR Signaling in human mouse rat
              Antiviral Response in human mouse rat
              Wound Healing in human mouse rat
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK3
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    QuantiFast Probe-based Assays in human, mouse, rat MAPK3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK3

    Orthologs
    for MAPK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK3 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mapk31 , 5 mitogen-activated protein kinase 31, 5 90.01(n)1
    97.28(a)1    		   7 (69.25 cM)5
    264171  NM_011952.21  NP_036082.11 
     1267596015 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPK36
    		 mitogen-activated protein kinase 3
    		 87(a)
    		 1 ↔ 1
    		 GL343279.1(412242-421979)
    zebrafish
    (Danio rerio)    		 Actinopterygii AB030902.12   -- 79.44(n)    AB030902.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG187323   -- 87(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea mpk-13 serine/threonine kinase (CDC2/CDC28
    subfamily)    		 77(a)
    (best of 8)    		   III(4289194-4299892)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes FUS31 FUS3 56.38(n)
    52.52(a)    		   852265   NP_009537.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MPK21 MPK2 55.62(n)
    50.45(a)    		   842248  NM_104651.4  NP_564746.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.4062 Oryza sativa mRNA for MAPK2 protein (mapk2 gene) 77.09(n)    AJ250311.1 


    ENSEMBL Gene Tree for MAPK3 (if available)
    TreeFam Gene Tree for MAPK3 (if available)

    Paralogs
    for MAPK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for MAPK3 gene
    MAPK42  MAPK72  NLK2  MAPK152  MAPK62  MAPK12  
    Selected SIMAP similar genes for MAPK3 using alignment to 10 protein entries:     MK03_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O0215    MAPK1    MAP3K3    DYRK4    MAPK7    MAPK14
    MAPK4    MAPK13    MAPK11    MAPK8    MAP4K1    NEK8
    PHKG2    MAPK15    NLK    SIK3    TLK2    AKT2

    MAPK3 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MAPK3 (see all 274)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs617642231,2
    		C,F--30127315(-) TGGATC/TACAAG 3 -- int13Minor allele frequency- T:0.02NS WA 92
    rs356663051,2
    		C--30130477(-) GTAGGT/-TTTTT 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs745869881,2
    		C,F--30135453(+) AGAGGT/AGGAGG 3 -- us2k12Minor allele frequency- A:0.50NA WA 4
    rs1459152391,2
    		--31024534(+) TTTCAC/GAGGAT 3 -- ds5001 int10--------
    rs1391480551,2
    		C--31024646(+) TGACCC/TCCTTC 3 -- ds5001 int10--------
    rs1836554281,2
    		--31024839(+) TTAGAC/TGGGTC 3 -- ut310--------
    rs118652281,2
    		C,F,H--31025037(+) TGAATG/AAGATG 3 -- ut313Minor allele frequency- A:0.04NS NA 98
    rs10424041,2
    		A--31025039(-) CTCATC/TTCATT 3 -- ut313Minor allele frequency- T:0.00MN NA 188
    rs785709151,2
    		C--31025084(+) CCCCCC/TACCCT 3 -- ut310--------
    rs76981,2
    		C,F,A,H--31025177(-) TGCTGC/TGCCCT 3 -- ut31 ese313Minor allele frequency- T:0.20MN NS EA NA WA 1336

    HapMap Linkage Disequilibrium report for MAPK3 (30125426 - 30134827 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MAPK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1781CNV Insertion18451855
    esv993894CNV Insertion20482838
    nsv833187CNV Loss17160897
    nsv905720CNV Loss21882294
    dgv846e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): MAPK3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK3
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK3

    Disorders / Diseases
    for MAPK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601795    OMIM disorders: --

    Selected diseases for MAPK3 (see all 152):    
    About MalaCards
    pleomorphic rhabdomyosarcoma    familial medullary thyroid carcinoma    corticobasal degeneration    brain ischemia
    cervical intraepithelial neoplasia    klebsiella    estrogen-receptor negative breast cancer    drug addiction
    cervical adenocarcinoma    hyperinsulinism    hiv/aids    prion disease
    breast adenocarcinoma    progressive supranuclear palsy    cervicitis    toxic encephalopathy
    lung squamous cell carcinoma    alcoholic hepatitis    mucoepidermoid carcinoma    adrenocortical carcinoma

    2 diseases from the University of Copenhagen DISEASES database for MAPK3:
    Cancer     Vascular disease

    MAPK3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for MAPK3 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 37.9 52 15854513 (2), 14749472 (2), 9223425 (2), 16138005 (2) (see all 39)
    breast cancer 33.5 24 15928662 (2), 11464287 (1), 11933076 (1), 10481052 (1) (see all 20)
    necrosis 31.7 11 16641451 (1), 16489115 (1), 12183057 (1), 15240747 (1) (see all 10)
    colon carcinoma 27.3 2 15735687 (1), 18533112 (1)
    glioblastoma 26.4 5 12165859 (1), 16012865 (1), 11115541 (1), 11234878 (1) (see all 5)
    cancer 25.8 6 8635462 (1), 15826073 (1), 15655810 (1), 18951930 (1) (see all 6)
    leukemia 21.6 4 19363496 (1), 15826073 (1), 11372759 (1)
    carcinoma squamous cell 20.7 13 11520272 (3), 18004471 (2), 1939237 (1), 18472963 (1) (see all 8)
    shock 16.9 14 15364926 (2), 11463862 (1), 17113785 (1), 8940068 (1) (see all 10)
    retinoblastoma 13.7 1 19665013 (1)

    Genetic Association Database (GAD): MAPK3
    Human Genome Epidemiology (HuGE) Navigator: MAPK3 (8 documents)

    Export disorders for MAPK3 gene to outside databases

    Publications
    for MAPK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for MAPK3 gene, integrated from 10 sources (see all 1923):
    (articles sorted by number of sources associating them with MAPK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PubMed id 10224087)1, 2, 9 Todd J.L.... Denu J.M. (J. Biol. Chem. 1999)
    2. Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1. (PubMed id 7687743)1, 2, 9 Charest D.L.... Mordret G. (Mol. Cell. Biol. 1993)
    3. Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs. (PubMed id 1540184)1, 2, 9 Owaki H.... Geppert T.D. (Biochem. Biophys. Res. Commun. 1992)
    4. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. (PubMed id 9155018)1, 2, 9 Fukunaga R. and Hunter T. (EMBO J. 1997)
    5. Heterogeneous expression of four MAP kinase isoforms in human tissues. (PubMed id 1319925)1, 2, 9 Gonzalez F.A.... Davis R.J. (FEBS Lett. 1992)
    6. Association and mutation analyses of 16p11.2 autism candidate genes. (PubMed id 19242545)1, 4 Kumar R.A....Christian S.L. (PLoS ONE 2009)
    7. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    8. The ERK signaling cascade--views from different subcellular compartments. (PubMed id 19565474)1, 2 Yao Z. and Seger R. (BioFactors 2009)
    9. A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. (PubMed id 19060905)1, 2 Lorenz K.... Lohse M.J. (Nat. Med. 2009)
    10. Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration. (PubMed id 19447520)1, 2 Won M....Hur G.M. (J. Hepatol. 2009)

    External Searches for MAPK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAPK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5595 HGNC: 6877 AceView: MAPK3andMGC4171 Ensembl:ENSG00000102882 euGenes: HUgn5595
    ECgene: MAPK3 Kegg: 5595 H-InvDB: MAPK3

    Other Databases showing MAPK3 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing MAPK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAPK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAPK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for MAPK3 gene:
    Search GeneIP for patents involving MAPK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MAPK3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     EMD Millipore Kits and Assays for the Analysis of MAPK3
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     QuantiFast Probe-based Assays in human, mouse, rat MAPK3 QuantiTect SYBR Green Assays in human, mouse, rat MAPK3
     PCR Arrays including human, mouse, rat MAPK3 Search Chromatin IP Primers for MAPK3
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     Antibodies & Assays for MAPK3  (ERK1)

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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK3
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK3
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