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MAPK3 Gene(Protein Coding)

Mitogen-Activated Protein Kinase 3

GCID:
GC16M030125
GIFtS:
73
Genes Participants
UDN Logo

Aliases for MAPK3 Gene

Aliases for MAPK3 Gene

  • Mitogen-Activated Protein Kinase 3 2 3 5
  • Extracellular Signal-Regulated Kinase 1 3 4
  • Microtubule-Associated Protein 2 Kinase 3 4
  • Insulin-Stimulated MAP2 Kinase 3 4
  • MAP Kinase Isoform P44 3 4
  • EC 2.7.11.24 4 61
  • P44-ERK1 3 4
  • P44-MAPK 3 4
  • PRKM3 3 4
  • ERK-1 3 4
  • ERK1 3 4
  • ERT2 3 4
  • Extracellular Signal-Related Kinase 1 3
  • MAP Kinase 3 4
  • EC 2.7.11 61
  • HS44KDAP 3
  • HUMKER1A 3
  • P44ERK1 3
  • P44MAPK 3
  • MAPK 1 3
  • MAPK 3 4

External Ids for MAPK3 Gene

Previous HGNC Symbols for MAPK3 Gene

  • PRKM3

Previous GeneCards Identifiers for MAPK3 Gene

  • GC16P029026
  • GC16M030447
  • GC16M030123
  • GC16M030162
  • GC16M030032
  • GC16M027786

Summaries for MAPK3 Gene

Entrez Gene Summary for MAPK3 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK3 Gene

MAPK3 (Mitogen-Activated Protein Kinase 3) is a Protein Coding gene. Diseases associated with MAPK3 include Small Intestine Neuroendocrine Neoplasm and Pilocytic Astrocytoma Of Cerebellum. Among its related pathways are CCR5 Pathway in Macrophages and Trk receptor signaling mediated by the MAPK pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK1.

UniProtKB/Swiss-Prot for MAPK3 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

Tocris Summary for MAPK3 Gene

  • Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.

Gene Wiki entry for MAPK3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK3 Gene

Genomics for MAPK3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MAPK3 Gene

Enhancers for MAPK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G030119 1.1 ENCODE 18 +1.3 1336 5.8 FOXA2 PKNOX1 MLX CREB3L1 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 MAPK3 YPEL3 CORO1A SLX1A-SULT1A3 BOLA2B SLX1A CD2BP2 GC16P030116
GH16G030130 0.9 ENCODE 21 -7.3 -7339 1.3 ELF3 PKNOX1 FOXA2 CBX3 MLX ARID4B ZNF48 ZSCAN9 RARA SLC30A9 MAPK3 YPEL3 CORO1A
GH16G030112 1.1 ENCODE 14.6 +8.7 8659 5.5 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 TBX6 MAPK3 CORO1A SLX1A SLX1A-SULT1A3 BOLA2B CD2BP2 DOC2A YPEL3 GC16P030116
GH16G030165 1.1 Ensembl ENCODE 10.9 -43.0 -42986 1.0 HDGF BMI1 ZNF335 ZNF766 CBX5 ETV6 RELB IKZF2 CREM EGR2 MAPK3 CORO1A
GH16G029644 1.3 Ensembl ENCODE 4.1 +478.3 478263 2.0 HDGF ATF1 MLX ARNT ARID4B DMAP1 ZNF48 YY1 ZNF766 ZNF207 SMG1P2 ENSG00000260853 NFATC2IP ENSG00000260367 ENSG00000198106 ZNF747 NPIPB13 ZNF764 RRN3P2 INO80E
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAPK3 on UCSC Golden Path with GeneCards custom track

Promoters for MAPK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085158 506 1601 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF766 GLIS2 ELK1 ZNF143 ZNF207

Transcription factor binding sites by QIAGEN in the MAPK3 gene promoter:

Genomic Location for MAPK3 Gene

Chromosome:
16
Start:
30,114,105 bp from pter
End:
30,123,506 bp from pter
Size:
9,402 bases
Orientation:
Minus strand

Genomic View for MAPK3 Gene

Genes around MAPK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAPK3 Gene

Proteins for MAPK3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27361-MK03_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 3
    Protein Accession:
    P27361
    Secondary Accessions:
    • A8CZ58
    • B0LPG3
    • Q8NHX1

    Protein attributes for MAPK3 Gene

    Size:
    379 amino acids
    Molecular mass:
    43136 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds both upstream activators and downstream substrates in multimolecular complexes. Found in a complex with at least BRAF, HRAS, MAP2K1/MEK1, MAPK3 and RGS14 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARRB2, CANX, DAPK1 (via death domain), HSF4, IER3, MAP2K1/MEK1, MORG1, NISCH, and SGK1. Interacts with PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with TPR. Interacts with CDKN2AIP. Interacts with HSF1 (via D domain and preferentially with hyperphosphorylated form); this interaction occurs upon heat shock (PubMed:10747973).

    Three dimensional structures from OCA and Proteopedia for MAPK3 Gene

    Alternative splice isoforms for MAPK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK3 Gene

Protein Expression for MAPK3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAPK3 Gene

P27361:
  • YVATRWYR
  • MELDDLPKE
  • GCILAEM
  • RVAIKKISPFEHQT
  • MRDVYIVQ
  • GLKYIHSA
  • DEPVAEE
  • FPGKHYLDQLN
  • YQILRGLKY
  • ILLRFRHEN
  • FDVGPRY
  • ALAHPYLEQYYDP
  • LKICDFG
  • HSANVLHRDL
  • LKYIHSA
  • TEYVATRWYRAPE
  • RVAIKKI
  • WSVGCILAE
  • YRAPEIML
  • VLHRDLK
  • DIWSVGCI
  • YIGEGAYGMV
  • TRWYRAPE
  • DVYIVQDLMETDLYKLLK
  • WSVGCIL
  • NHILGIL
  • LKICDFGLAR
  • ETARFQPG

Post-translational modifications for MAPK3 Gene

  • Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204.
  • Ubiquitination at posLast=317317
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MAPK3 Gene

Gene Families for MAPK3 Gene

HGNC:
IUPHAR :

Protein Domains for MAPK3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAPK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27361

UniProtKB/Swiss-Prot:

MK03_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK3: view

Function for MAPK3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for MAPK3 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase 3 (MAP kinase) (p44),insulin activated map kinase,highly expressed in lung and in head and neck squamous cell carcinoma
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-202 and Tyr-204 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

Enzyme Numbers (IUBMB) for MAPK3 Gene

Gene Ontology (GO) - Molecular Function for MAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001784 phosphotyrosine binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004707 MAP kinase activity TAS --
genes like me logo Genes that share ontologies with MAPK3: view
genes like me logo Genes that share phenotypes with MAPK3: view

Animal Models for MAPK3 Gene

MGI Knock Outs for MAPK3:

Animal Model Products

CRISPR Products

miRNA for MAPK3 Gene

miRTarBase miRNAs that target MAPK3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MAPK3

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK3 Gene

Localization for MAPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK3 Gene

Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5
golgi apparatus 5
endosome 5
peroxisome 2
endoplasmic reticulum 2
lysosome 2

Gene Ontology (GO) - Cellular Components for MAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus TAS 19565474
GO:0005635 nuclear envelope IDA 20455999
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MAPK3: view

Pathways & Interactions for MAPK3 Gene

SuperPathways for MAPK3 Gene

PathCards logo More details on SuperPathways for MAPK3
SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
NCAM signaling for neurite out-growth
.89
DAP12 interactions
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.56
2 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
3 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
Growth Hormone Signaling
.49
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
LPS Stimulated MAPK Signaling
.47
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
PACAP Signaling
.37
HMGB1 Pathway
.36
PI3K Signaling in B-Lymphocyte
.35
IL-4 Pathway
.34
4 Regulation of lipid metabolism Insulin signaling-generic cascades
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Transcription Receptor-mediated HIF regulation
.51
Translation Regulation of EIF2 activity
.47
Translation Regulation of EIF4F activity
.44
Development CNTF receptor signaling
.43
Cell adhesion PLAU signaling
.35
Insulin signaling pathway
.32
ErbB2/ErbB3 signaling events
.31
Signal attenuation
.01
5 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
IL-21 Signaling Pathways
.90
IL-7 Signaling Pathways
.90
IL-9 Signaling Pathways
.90
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.90
IL-15 Signaling Pathways
.88
IL-2 Signaling Pathways
.88
IL-4 Signaling Pathways
.84
Immune response IL-9 signaling pathway
.42
Development Thrombopoietin-regulated cell processes
.38
Adipokines and Insulin Signaling Pathways
.34
genes like me logo Genes that share pathways with MAPK3: view

Pathways by source for MAPK3 Gene

1 GeneTex pathway for MAPK3 Gene
1 Cell Signaling Technology pathway for MAPK3 Gene

SIGNOR curated interactions for MAPK3 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000189 MAPK import into nucleus IEA --
GO:0001934 positive regulation of protein phosphorylation IMP 19664780
GO:0002741 positive regulation of cytokine secretion involved in immune response IEA --
genes like me logo Genes that share ontologies with MAPK3: view

Drugs & Compounds for MAPK3 Gene

Products:

  1. Drug

(104) Drugs for MAPK3 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma inhibitor, Target, inducer 122
Sulindac Approved Pharma Target, inhibitor Anti-inflammatory agent;COX inhibitor 37
Trisenox Approved September 2000 Pharma 0
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 519
Sumatriptan Approved, Investigational Pharma Full agonist, Agonist 5-HT1 receptor agonist 101

(56) Additional Compounds for MAPK3 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
ERK5-IN-1
1435488-37-1
TCS ERK 11e
896720-20-0

(5) Tocris Compounds for MAPK3 Gene

Compound Action Cas Number
Eicosapentaenoic Acid Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation 10417-94-4
ERK5-IN-1 Potent and selective ERK5 inhibitor 1435488-37-1
FR 180204 Selective ERK inhibitor 865362-74-9
TCS ERK 11e Potent and selective ERK2 inhibitor 896720-20-0
XMD 8-92 ERK5/BMK1 inhibitor 1234480-50-2

(8) ApexBio Compounds for MAPK3 Gene

Compound Action Cas Number
DEL-22379 inhibitor of the dimerization of ERK 181223-80-3
FR 180204 ERK inhibitor 865362-74-9
Matrine Alkaloid found in Sophora plant 519-02-8
Piperine MAPK inhibitor 94-62-2
Pluripotin 839707-37-8
SCH772984 ERK1 and ERK2 inhibitor 942183-80-4
VRT752271 ERK1/ERK2 inhibitor 869886-67-9
VX-11e ERK inhibitor 896720-20-0
genes like me logo Genes that share compounds with MAPK3: view

Drug Products

Transcripts for MAPK3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MAPK3 Gene

(3) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(477) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAPK3 Gene

Mitogen-activated protein kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MAPK3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - -
SP3: - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: - - - - - -
SP7: - -
SP8: - -
SP9:

Relevant External Links for MAPK3 Gene

GeneLoc Exon Structure for
MAPK3
ECgene alternative splicing isoforms for
MAPK3

Expression for MAPK3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPK3 Gene

mRNA expression in normal human tissues for MAPK3 Gene
mRNA expression by BioGPS for MAPK3 GenemRNA expression by GTEx for MAPK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPK3 Gene

This gene is overexpressed in Brain (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPK3 Gene



Protein tissue co-expression partners for MAPK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAPK3 Gene:

MAPK3

SOURCE GeneReport for Unigene cluster for MAPK3 Gene:

Hs.861

Evidence on tissue expression from TISSUES for MAPK3 Gene

  • Nervous system(4.6)
  • Eye(3.7)
  • Muscle(3.6)
  • Heart(3.5)
  • Lung(3.4)
  • Intestine(3.1)
  • Kidney(3.1)
  • Adrenal gland(3)
  • Blood(3)
  • Skin(3)
  • Bone marrow(2.8)
  • Liver(2.7)
  • Lymph node(2.7)
  • Spleen(2.7)
  • Stomach(2.7)
  • Pancreas(2.6)
  • Thyroid gland(2.5)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with MAPK3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK3 Gene

Orthologs for MAPK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MAPK3 34 35
  • 97 (n)
oppossum
(Monodelphis domestica)
 Mammalia MAPK3 35
  • 94 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia MAPK3 34 35
  • 92.82 (n)
dog
(Canis familiaris)
 Mammalia LOC479790 34
  • 91.92 (n)
MAPK3 35
  • 90 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mapk3 34 16 35
  • 90.01 (n)
rat
(Rattus norvegicus)
 Mammalia Mapk3 34
  • 89.55 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 73 (a)
 OneToMany
-- 35
  • 71 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia MAPK3 35
  • 87 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii mapk3 34 35
  • 78.21 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG18732 36
  • 87 (a)
rl 36 35
  • 81 (a)
worm
(Caenorhabditis elegans)
 Secernentea mpk-1 36 35
  • 77 (a)
C05D10.2a 36
  • 41 (a)
C05D10.2c 36
  • 41 (a)
F09C12.2 36
  • 41 (a)
pmk-3 36
  • 39 (a)
Y51B9A.9 36
  • 34 (a)
H01G02.2 36
  • 32 (a)
C49C3.10b 36
  • 31 (a)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AFR019W 34
  • 59.9 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes FUS3 34 35
  • 56.38 (n)
KSS1 35
  • 46 (a)
 ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E10539g 34
  • 54.04 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons MPK2 34
  • 55.62 (n)
rice
(Oryza sativa)
 Liliopsida Os02g0148100 34
  • 55.26 (n)
Os.406 34
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.9711 35
  • 80 (a)
 OneToMany
bread mold
(Neurospora crassa)
 Ascomycetes NCU02393 34
  • 62.99 (n)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes spk1 34
  • 52.85 (n)
Species where no ortholog for MAPK3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAPK3 Gene

ENSEMBL:
Gene Tree for MAPK3 (if available)
TreeFam:
Gene Tree for MAPK3 (if available)

Paralogs for MAPK3 Gene

Paralogs for MAPK3 Gene

(86) SIMAP similar genes for MAPK3 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with MAPK3: view

Variants for MAPK3 Gene

Sequence variations from dbSNP and Humsavar for MAPK3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000319102 -- 30,122,938(+) GGGAC(A/G)CTCCG intron-variant
rs1000539202 -- 30,123,413(+) CCCTG(C/G)GGGCT upstream-variant-2KB
rs1000548119 -- 30,115,735(+) GGCCA(C/G/T)CAGTC intron-variant
rs1000906404 -- 30,118,001(+) GGCTT(C/T)CTGGG intron-variant
rs1000919414 -- 30,116,280(+) GTGAT(C/T)CACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK3 Gene

Variant ID Type Subtype PubMed ID
esv2758642 CNV gain 17122850
esv993894 CNV insertion 20482838
nsv1160384 CNV duplication 26073780
nsv1781 CNV insertion 18451855
nsv833187 CNV loss 17160897

Variation tolerance for MAPK3 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK3 Gene

Human Gene Mutation Database (HGMD)
MAPK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK3 Gene

Disorders for MAPK3 Gene

MalaCards: The human disease database

(18) MalaCards diseases for MAPK3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
small intestine neuroendocrine neoplasm
  • small intestine neuroendocrine tumor
pilocytic astrocytoma of cerebellum
  • cerebellar pilocytic astrocytoma
adrenal cortical adenocarcinoma
  • adrenocortical carcinoma
acromesomelic dysplasia, maroteaux type
  • acromesomelic dysplasia maroteaux type
squamous cell carcinoma
  • epidermoid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MAPK3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAPK3

Genetic Association Database (GAD)
MAPK3
Human Genome Epidemiology (HuGE) Navigator
MAPK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK3
genes like me logo Genes that share disorders with MAPK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK3 Gene

Publications for MAPK3 Gene

  1. Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1. (PMID: 7687743) Charest D.L. … Mordret G. (Mol. Cell. Biol. 1993) 3 4 22 64
  2. Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs. (PMID: 1540184) Owaki H. … Geppert T.D. (Biochem. Biophys. Res. Commun. 1992) 3 4 22 64
  3. Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. (PMID: 24825908) Cheung C.T. … Wadhwa R. (J. Biol. Chem. 2014) 3 4 64
  4. ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. (PMID: 20385094) Shin S. … Blenis J. (Mol. Cell 2010) 3 22 64
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64

Products for MAPK3 Gene