Aliases for MAPK3 Gene
Aliases for MAPK3 Gene
External Ids for MAPK3 Gene
- HGNC: 6877
- Entrez Gene: 5595
- Ensembl: ENSG00000102882
- OMIM: 601795
- UniProtKB: P27361
Previous HGNC Symbols for MAPK3 Gene
- PRKM3
Previous GeneCards Identifiers for MAPK3 Gene
- GC16P029026
- GC16M030447
- GC16M030123
- GC16M030162
- GC16M030032
- GC16M027786
Summaries for MAPK3 Gene
-
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAPK3 Gene
MAPK3 (Mitogen-Activated Protein Kinase 3) is a Protein Coding gene. Diseases associated with MAPK3 include Small Intestine Neuroendocrine Neoplasm and Pilocytic Astrocytoma Of Cerebellum. Among its related pathways are CCR5 Pathway in Macrophages and Trk receptor signaling mediated by the MAPK pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK1.
UniProtKB/Swiss-Prot for MAPK3 Gene
-
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
-
Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK3 Gene
Genomics for MAPK3 Gene
Regulatory Elements for MAPK3 Gene
Enhancers for MAPK3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH16G030119 | 1.1 | ENCODE | 18 | +1.3 | 1336 | 5.8 | FOXA2 PKNOX1 MLX CREB3L1 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 | MAPK3 YPEL3 CORO1A SLX1A-SULT1A3 SLX1A BOLA2B CD2BP2 GC16P030116 |
| GH16G030130 | 0.9 | ENCODE | 21 | -7.3 | -7339 | 1.3 | ELF3 PKNOX1 FOXA2 CBX3 MLX ARID4B ZNF48 ZSCAN9 RARA SLC30A9 | MAPK3 YPEL3 CORO1A |
| GH16G030112 | 1.1 | ENCODE | 14.6 | +8.7 | 8659 | 5.5 | HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 | TBX6 MAPK3 CORO1A BOLA2B SLX1A SLX1A-SULT1A3 CD2BP2 DOC2A YPEL3 GC16P030116 |
| GH16G030165 | 1.1 | Ensembl ENCODE | 10.9 | -43.0 | -42986 | 1.0 | HDGF BMI1 ZNF335 ZNF766 CBX5 ETV6 RELB IKZF2 CREM EGR2 | MAPK3 CORO1A |
| GH16G029644 | 1.3 | Ensembl ENCODE | 4.1 | +478.3 | 478263 | 2.0 | HDGF ATF1 MLX ARNT ARID4B DMAP1 ZNF48 YY1 ZNF766 ZNF207 | SMG1P2 ENSG00000260853 NFATC2IP ENSG00000260367 ENSG00000198106 ZNF747 NPIPB13 ZNF764 RRN3P2 INO80E |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MAPK3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MAPK3 gene promoter:
Regulatory Element Products
Genomic Location for MAPK3 Gene
- Chromosome:
- 16
- Start:
- 30,114,105 bp from pter
- End:
- 30,123,506 bp from pter
- Size:
- 9,402 bases
- Orientation:
- Minus strand
Genomic View for MAPK3 Gene
Genes around MAPK3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by Ensembl
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC
MAPK3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAPK3 Gene
Proteins for MAPK3 Gene
-
Protein details for MAPK3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P27361-MK03_HUMAN
- Recommended name:
- Mitogen-activated protein kinase 3
- Protein Accession:
- P27361
- A8CZ58
- B0LPG3
- Q8NHX1
Protein attributes for MAPK3 Gene
- Size:
- 379 amino acids
- Molecular mass:
- 43136 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Binds both upstream activators and downstream substrates in multimolecular complexes. Found in a complex with at least BRAF, HRAS, MAP2K1/MEK1, MAPK3 and RGS14 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARRB2, CANX, DAPK1 (via death domain), HSF4, IER3, MAP2K1/MEK1, MORG1, NISCH, and SGK1. Interacts with PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with TPR. Interacts with CDKN2AIP. Interacts with HSF1 (via D domain and preferentially with hyperphosphorylated form); this interaction occurs upon heat shock (PubMed:10747973).
Protein Expression for MAPK3 Gene
Selected DME Specific Peptides for MAPK3 Gene
- P27361:
-
- YVATRWYR
- MELDDLPKE
- GCILAEM
- RVAIKKISPFEHQT
- MRDVYIVQ
- GLKYIHSA
- DEPVAEE
- FPGKHYLDQLN
- YQILRGLKY
- ILLRFRHEN
- FDVGPRY
- ALAHPYLEQYYDP
- LKICDFG
- HSANVLHRDL
- LKYIHSA
- TEYVATRWYRAPE
- RVAIKKI
- WSVGCILAE
- YRAPEIML
- VLHRDLK
- DIWSVGCI
- YIGEGAYGMV
- TRWYRAPE
- DVYIVQDLMETDLYKLLK
- WSVGCIL
- NHILGIL
- LKICDFGLAR
- ETARFQPG
Post-translational modifications for MAPK3 Gene
- Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-204.
- Ubiquitination at posLast=317317
- Modification sites at PhosphoSitePlus
Other Protein References for MAPK3 Gene
Antibody Products
- R&D Systems Antibodies for MAPK3 (ERK1)
- Cell Signaling Technology (CST) Antibodies for MAPK3 (ERK1)
-
Custom Antibody ServicesOriGene Antibodies for MAPK3
- TA505700JM
- TA505700HM
- TA505700GM
- TA505700FM
- TA505700EM
- TA505700DM
- TA505700CM
- TA505700BM
- TA505700AM
- CF505700
- TA505700
- TA353804
- TA341170
- TA341094
- TA341093
- TA326229
- TA326220
- TA325660
- TA325659
- TA325658
- TA325657
- TA325656
- TA325139
- TA324941
- TA324783
- TA302659
- AP20886PU-N
- AP20727PU-N
- AP20726PU-N
- AP20379PU-N
- AP16365PU-T
- AP15539PU-S
- AP15539PU-N
- AP15539PU-M
- AP06107PU-N
- AP05182PU-N
- AP02498PU-S
- AP02498PU-N
- AM31819PU-N
- AM09379PU-S
- AM09379PU-N
- AM06672SU-N
- AM00084PU-N
- AM00084FC-N
- AM00084BT-N
- Novus Biologicals Antibodies for MAPK3
-
Abcam antibodies for MAPK3
-
Cloud-Clone Corp. Antibodies for MAPK3
- Invitrogen Antibodies for MAPK3
- antibodies-online Antibodies for MAPK3: See all 435
- GeneTex MAPK3 antibody for MAPK3
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAPK3
Protein Products
- R&D Systems Proteins and Enzymes for MAPK3 (ERK1)
-
OriGene Purified Proteins for MAPK3
- Search Origene for MassSpec and Protein Over-expression Lysates for MAPK3
- Origene Custom Protein Services for MAPK3
- ProSpec Recombinant Proteins for MAPK3
-
Cloud-Clone Corp. Proteins for MAPK3
- antibodies-online Proteins for MAPK3: See all 34
- Search antibodies-online for peptides
- GeneTex Proteins for MAPK3
-
Abcam proteins for MAPK3
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for MAPK3 (ERK1)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK3 (ERK1)
-
Cloud-Clone Corp Assay Kits for MAPK3
- antibodies-online Kits for MAPK3: See all 48
-
Abcam assays for MAPK3
Domains & Families for MAPK3 Gene
Gene Families for MAPK3 Gene
Protein Domains for MAPK3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAPK3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P27361UniProtKB/Swiss-Prot:
MK03_HUMAN :- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Domain:
-
- The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
- Family:
-
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Function for MAPK3 Gene
Molecular function for MAPK3 Gene
- GENATLAS Biochemistry:
- mitogen-activated protein kinase 3 (MAP kinase) (p44),insulin activated map kinase,highly expressed in lung and in head and neck squamous cell carcinoma
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-202 and Tyr-204 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9.
- UniProtKB/Swiss-Prot Function:
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
Enzyme Numbers (IUBMB) for MAPK3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0001784 | phosphotyrosine binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0004707 | MAP kinase activity | TAS | -- |
Phenotypes for MAPK3 Gene
- MGI mutant phenotypes for MAPK3:
-
inferred from 3 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for MAPK3:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased viability
- Decreased substrate adherent cell growth
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell migration
- Decreased telomerase activity
- Decreased viability with paclitaxel
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MAPK3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for MAPK3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK3 gene
- Search ViGene Biosciences for MAPK3
CRISPR Products
-
OriGene CRISPR knockouts for MAPK3
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK3
- GenScript: Design CRISPR guide RNA sequences for MAPK3
miRNA for MAPK3 Gene
- miRTarBase miRNAs that target MAPK3
miRNA Products
- Search ViGene Biosciences for MAPK3
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for MAPK3
- Browse OriGene Inhibitory RNA Products For MAPK3
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK3 gene
Clone Products
- Sino Biological Human cDNA Clone for MAPK3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MAPK3
- VectorBuilder custom plasmid, inducible vectors for MAPK3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MAPK3
-
ViGene Biosciences adenoviral particle packaged cDNA for MAPK3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MAPK3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK3 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK3 Gene
Localization for MAPK3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MAPK3 Gene
- Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | TAS | 19565474 |
| GO:0005635 | nuclear envelope | IDA | 20455999 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for MAPK3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Activated TLR4 signalling | ||
| 3 | IL-2 Pathway |
.59
.48
|
.43
.37
.36
.34
|
| 4 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
| 5 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways | ||
Pathways by source for MAPK3 Gene
11 Sino Biological pathways for MAPK3 Gene
1 GeneTex pathway for MAPK3 Gene
1 Cell Signaling Technology pathway for MAPK3 Gene
102 BioSystems pathways for MAPK3 Gene
134 Reactome pathways for MAPK3 Gene
94 KEGG pathways for MAPK3 Gene
86 GeneGo (Thomson Reuters) pathways for MAPK3 Gene
19 R&D Systems pathways for MAPK3 Gene
6 Tocris pathways for MAPK3 Gene
134 Qiagen pathways for MAPK3 Gene
Interacting Proteins for MAPK3 Gene
Selected Interacting proteins:
ENSP00000263025
P27361-MK03_HUMAN
for MAPK3 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for MAPK3 Gene
- Activates:
-
- ELK1
- FOS
- TH
- PLA2G4A
- RPS6KA1
- TAL1
- NCF1
- RPS6KA2
- MKNK1
- MKNK2
- RPS6KA4
- STAT5A
- SMAD2
- DUSP1
- GTF2I
- BCL2
- PTTG1
- SREBF1
- RPS6KA3
- PLCB1
- HSPB8
- RPS6KB1
- MAZ
- SP1
- ETS1
- RXRA
- ADAM17
- ATF2
- NCOA1
- JUN
- MED1
- RRN3
- PTK2
- SMAD4
- THRB
- TP53
- SPHK1
- STAT3
- NCKIPSD
- SYN3
- IL16
- E2F1
- MAPKAPK2
- SREBF2
- CAPN2
- PML
- GAB2
- RPS6KA5
- NFATC4
- CAD
- RPS3
- GRB10
- H3F3A
- RAF1
- MCL1
- CIITA
- SPHK2
- ESR1
- SP3
- NOS2
- ARHGEF2
- HIF1A
- MAPK3
- CEBPB
- RPTOR
- KARS
- BAZ1B
- RUNX2
- MAGEA11
- CTTN
- SOX9
- LRP6
- ABI1
- TWIST1
- JUND
- HDAC6
- Inactivates:
-
- EGFR
- MBP
- SOS1
- LIFR
- LCK
- MYB
- HSF1
- BCL6
- RAF1
- SMAD1
- SMAD2
- SMAD3
- ARRB1
- CALD1
- GRK2
- NFATC1
- PGR
- BCL2
- PDE4D
- CDKN1B
- HNRNPK
- UBTF
- TAL1
- TOB1
- NR3C1
- CASP9
- THRB
- POLR2A
- CEBPA
- PAK1
- IRS1
- ETV6
- LAT
- AMPH
- BCL2L11
- DUSP6
- PCYT1A
- GSK3B
- DUSP1
- PPP2R5C
- BRAF
- JAK2
- CIITA
- PPARG
- MKL1
- TSC2
- TFCP2
- FOXO3
- SULT4A1
- NUP50
- BAD
- NOXA1
- CIC
- KLC1
- POU5F1
- FGFR1
- CASP8
- Is activated by:
- Is inactivated by:
- Other effect:
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000187 | activation of MAPK activity | TAS | -- |
| GO:0000189 | MAPK import into nucleus | IEA | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IMP | 19664780 |
| GO:0002741 | positive regulation of cytokine secretion involved in immune response | IEA | -- |
Drugs & Compounds for MAPK3 Gene
(104) Drugs for MAPK3 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Arsenic trioxide | Approved, Investigational | Pharma | inhibitor, Target, inducer | 122 | ||
| Sulindac | Approved | Pharma | Target, inhibitor | Anti-inflammatory agent;COX inhibitor | 37 | |
| Trisenox | Approved September 2000 | Pharma | 0 | |||
| Simvastatin | Approved | Pharma | Competitive, Inhibitor | HMG-CoA reductase inhibitor | 519 | |
| Sumatriptan | Approved, Investigational | Pharma | Full agonist, Agonist | 5-HT1 receptor agonist | 101 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| ERK5-IN-1 |
|
1435488-37-1 |
|
|
||
| TCS ERK 11e |
|
896720-20-0 |
|
|
(5) Tocris Compounds for MAPK3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Eicosapentaenoic Acid | Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation | 10417-94-4 |
| ERK5-IN-1 | Potent and selective ERK5 inhibitor | 1435488-37-1 |
| FR 180204 | Selective ERK inhibitor | 865362-74-9 |
| TCS ERK 11e | Potent and selective ERK2 inhibitor | 896720-20-0 |
| XMD 8-92 | ERK5/BMK1 inhibitor | 1234480-50-2 |
(8) ApexBio Compounds for MAPK3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| DEL-22379 | inhibitor of the dimerization of ERK | 181223-80-3 |
| FR 180204 | ERK inhibitor | 865362-74-9 |
| Matrine | Alkaloid found in Sophora plant | 519-02-8 |
| Piperine | MAPK inhibitor | 94-62-2 |
| Pluripotin | 839707-37-8 | |
| SCH772984 | ERK1 and ERK2 inhibitor | 942183-80-4 |
| VRT752271 | ERK1/ERK2 inhibitor | 869886-67-9 |
| VX-11e | ERK inhibitor | 896720-20-0 |
Transcripts for MAPK3 Gene
mRNA/cDNA for MAPK3 Gene
- (3) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (477) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MAPK3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MAPK3
-
Santa Cruz Biotechnology (SCBT) CRISPR for MAPK3
- GenScript: Design CRISPR guide RNA sequences for MAPK3
miRNA Products
- Search ViGene Biosciences for MAPK3
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for MAPK3
- Browse OriGene Inhibitory RNA Products For MAPK3
-
ViGene Biosciences ready-to-package AAV shRNAs for MAPK3 gene
Clone Products
- Sino Biological Human cDNA Clone for MAPK3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for MAPK3
- VectorBuilder custom plasmid, inducible vectors for MAPK3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAPK3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for MAPK3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Smooth Muscle (Muscoskeletal System)
This gene is overexpressed in Brain (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPK3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MAPK3 Gene:
MAPK3SOURCE GeneReport for Unigene cluster for MAPK3 Gene:
Hs.861Evidence on tissue expression from TISSUES for MAPK3 Gene
- Nervous system(4.6)
- Eye(3.7)
- Muscle(3.6)
- Heart(3.5)
- Lung(3.4)
- Intestine(3.1)
- Kidney(3.1)
- Adrenal gland(3)
- Blood(3)
- Skin(3)
- Bone marrow(2.8)
- Liver(2.7)
- Lymph node(2.7)
- Spleen(2.7)
- Stomach(2.7)
- Pancreas(2.6)
- Thyroid gland(2.5)
- Bone(2.2)
Primer Products
-
OriGene qPCR primer pairs for MAPK3
-
OriGene qPCR primer pairs and template standards for MAPK3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK3 Gene
Orthologs for MAPK3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MAPK3 35 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | MAPK3 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MAPK3 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LOC479790 34 |
|
||
| MAPK3 35 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Mapk3 35 16 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mapk3 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | MAPK3 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | mapk3 35 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG18732 36 |
|
|
|
| rl 36 35 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | mpk-1 36 35 |
|
||
| C05D10.2a 36 |
|
|
|||
| C05D10.2c 36 |
|
|
|||
| F09C12.2 36 |
|
|
|||
| pmk-3 36 |
|
|
|||
| Y51B9A.9 36 |
|
|
|||
| H01G02.2 36 |
|
|
|||
| C49C3.10b 36 |
|
|
|||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR019W 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FUS3 34 35 |
|
||
| KSS1 35 |
|
ManyToMany | |||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E10539g 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | MPK2 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0148100 34 |
|
||
| Os.406 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9711 35 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU02393 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | spk1 34 |
|
- Species where no ortholog for MAPK3 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for MAPK3 Gene
(86) SIMAP similar genes for MAPK3 Gene using alignment to 10 proteins:
- DKFZp686O0215
- MAPK1
- MAP3K3
- DYRK4
- MAPK7
- MAPK14
- MAPK4
- MAPK13
- MAPK11
- MAPK8
- PHKG2
- NEK8
- MAP4K1
- MAPK15
- NLK
- TLK2
- SIK3
- DKFZp686M02159
- AKT2
- MAPK12
- MAPK10
- STK11
- NEK9
- PRKACA
- PKN1
- OBSCN
- MAPK9
- CCRK
- ERBB2
- EGFR
- MAP4K5
- CDK7
- MST094
- CDK20
- CSNK2A3
- CDK5
- CDK18
- CDK3
- STK25
- CDK14
- CDK16
- CDK12
- CDK11B
- ULK1
- CSNK2A1
- AURKB
- DKFZp564L2416
- DKFZp686D0638
- CDC2L1
- CDK1
- RPS6KA2
- MOK
- STK36
- TXK
- SGK494
- CDK11A
- CDC2L2
- FLT4
- MAK
- CDKL2
- CDK17
- GSK3A
- CDC2
- PCTK1
- CDKL1
- PCTK3
- WNK4
- DKFZp686L20222
- CDK10
- CDKL4
- FLT1
- CDK2
- CDK6
- CDKL3
- GSK3B
- FGFR1
- CDK4
- CSNK1D
- DAPK3
- CDK19
- NUAK1
- CDK15
- CDK9
- PRKD3
- HUNK
- CHEK1
Variants for MAPK3 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000319102 | -- | 30,122,938(+) | GGGAC(A/G)CTCCG | intron-variant | |
| rs1000539202 | -- | 30,123,413(+) | CCCTG(C/G)GGGCT | upstream-variant-2KB | |
| rs1000548119 | -- | 30,115,735(+) | GGCCA(C/G/T)CAGTC | intron-variant | |
| rs1000906404 | -- | 30,118,001(+) | GGCTT(C/T)CTGGG | intron-variant | |
| rs1000919414 | -- | 30,116,280(+) | GTGAT(C/T)CACTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758642 | CNV | gain | 17122850 |
| esv993894 | CNV | insertion | 20482838 |
| nsv1160384 | CNV | duplication | 26073780 |
| nsv1781 | CNV | insertion | 18451855 |
| nsv833187 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.66;
14.13% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MAPK3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK3 Gene
Disorders for MAPK3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| small intestine neuroendocrine neoplasm |
|
|
| pilocytic astrocytoma of cerebellum |
|
|
| adrenal cortical adenocarcinoma |
|
|
| acromesomelic dysplasia, maroteaux type |
|
|
| squamous cell carcinoma |
|
Search MAPK3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MAPK3
No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK3 Gene
Publications for MAPK3 Gene
- Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1. (PMID: 7687743) Charest D.L. … Mordret G. (Mol. Cell. Biol. 1993) 3 4 22 64
- Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs. (PMID: 1540184) Owaki H. … Geppert T.D. (Biochem. Biophys. Res. Commun. 1992) 3 4 22 64
- Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. (PMID: 24825908) Cheung C.T. … Wadhwa R. (J. Biol. Chem. 2014) 3 4 64
- ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. (PMID: 20385094) Shin S. … Blenis J. (Mol. Cell 2010) 3 22 64
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
Products for MAPK3 Gene
- R&D Systems Antibodies for MAPK3 (ERK1)
- R&D Systems Proteins and Enzymes for MAPK3 (ERK1)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for MAPK3 (ERK1)
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- AM00084BT-N
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- AM31819PU-N
- AP02498PU-N
- AP02498PU-S
- AP05182PU-N
- AP06107PU-N
- AP15539PU-M
- AP15539PU-N
- AP15539PU-S
- AP16365PU-T
- AP20379PU-N
- AP20726PU-N
- AP20727PU-N
- AP20886PU-N
- TA302659
- TA324783
- TA324941
- TA325139
- TA325656
- TA325657
- TA325658
- TA325659
- TA325660
- TA326220
- TA326229
- TA341093
- TA341094
- TA341170
- TA353804
- TA505700
- CF505700
- TA505700AM
- TA505700BM
- TA505700CM
- TA505700DM
- TA505700EM
- TA505700FM
- TA505700GM
- TA505700HM
- TA505700JM
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- OriGene qPCR primer pairs and template standards for MAPK3
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- OriGene CRISPR knockouts for MAPK3
- OriGene ORF clones in human for MAPK3
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- Cell Signaling Technology (CST) Antibodies for MAPK3 (ERK1)
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- Sino Biological Human cDNA Clone for MAPK3
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- Novus Biologicals Antibodies for MAPK3
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