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Aliases for MAPK1IP1L Gene

Aliases for MAPK1IP1L Gene

  • Mitogen-Activated Protein Kinase 1 Interacting Protein 1 Like 2 3 5
  • C14orf32 3 4
  • Mitogen-Activated Protein Kinase 1-Interacting Protein 1-Like 4
  • MAPK-Interacting And Spindle-Stabilizing Protein-Like 3
  • MAPK-Interacting And Spindle-Stabilizing Protein 3
  • Chromosome 14 Open Reading Frame 32 2
  • C14_5346 3
  • MISS 3

External Ids for MAPK1IP1L Gene

Previous HGNC Symbols for MAPK1IP1L Gene

  • C14orf32

Previous GeneCards Identifiers for MAPK1IP1L Gene

  • GC14P054589
  • GC14P055518
  • GC14P035680

Summaries for MAPK1IP1L Gene

GeneCards Summary for MAPK1IP1L Gene

MAPK1IP1L (Mitogen-Activated Protein Kinase 1 Interacting Protein 1 Like) is a Protein Coding gene.

Gene Wiki entry for MAPK1IP1L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK1IP1L Gene

Genomics for MAPK1IP1L Gene

Regulatory Elements for MAPK1IP1L Gene

Enhancers for MAPK1IP1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G055097 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.4 +51.8 51774 12.7 MLX DMAP1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D GLIS1 NBN LGALS3 LOC105370509 MAPK1IP1L GCH1 DLGAP5 FBXO34 ENSG00000259318 ATG14 GC14M055058 GC14M055059
GH14G055070 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +23.3 23265 8.6 HDGF PKNOX1 WRNIP1 BRCA1 ZNF121 GATA2 ZNF143 FOS JUNB TBX21 LGALS3 LOC105370509 MAPK1IP1L FBXO34 ATG14 GC14M055059 GC14M055058
GH14G055025 1.1 ENCODE 11.2 -24.5 -24505 3.5 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 LOC105370509 ENSG00000259318 MAPK1IP1L WDHD1
GH14G055079 0.9 ENCODE dbSUPER 12.1 +28.0 28047 0.1 MTA2 NR2F1 BACH1 TRIM22 BMI1 DPF2 TBX21 JUND ARID3A IKZF1 MAPK1IP1L GC14M055058 GC14M055059 LGALS3
GH14G055084 0.8 ENCODE dbSUPER 11.8 +33.7 33663 1.6 RFX1 HLF CUX1 ZNF652 SPI1 LOC105370509 MAPK1IP1L LGALS3 DLGAP5 GC14M055058 GC14M055059
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAPK1IP1L on UCSC Golden Path with GeneCards custom track

Promoters for MAPK1IP1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000068788 469 1801 HDGF HNRNPUL1 PKNOX1 MLX ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A

Genomic Location for MAPK1IP1L Gene

Chromosome:
14
Start:
55,051,631 bp from pter
End:
55,070,194 bp from pter
Size:
18,564 bases
Orientation:
Plus strand

Genomic View for MAPK1IP1L Gene

Genes around MAPK1IP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK1IP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK1IP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK1IP1L Gene

Proteins for MAPK1IP1L Gene

  • Protein details for MAPK1IP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDC0-MISSL_HUMAN
    Recommended name:
    MAPK-interacting and spindle-stabilizing protein-like
    Protein Accession:
    Q8NDC0
    Secondary Accessions:
    • B2RDD8
    • Q96BG5

    Protein attributes for MAPK1IP1L Gene

    Size:
    245 amino acids
    Molecular mass:
    24269 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAPK1IP1L Gene

Post-translational modifications for MAPK1IP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK1IP1L Gene

No data available for DME Specific Peptides for MAPK1IP1L Gene

Domains & Families for MAPK1IP1L Gene

Protein Domains for MAPK1IP1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAPK1IP1L Gene

Graphical View of Domain Structure for InterPro Entry

Q8NDC0

UniProtKB/Swiss-Prot:

MISSL_HUMAN :
  • Belongs to the MISS family.
Family:
  • Belongs to the MISS family.
genes like me logo Genes that share domains with MAPK1IP1L: view

No data available for Gene Families for MAPK1IP1L Gene

Function for MAPK1IP1L Gene

Gene Ontology (GO) - Molecular Function for MAPK1IP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MAPK1IP1L: view
genes like me logo Genes that share phenotypes with MAPK1IP1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAPK1IP1L Gene

Localization for MAPK1IP1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK1IP1L gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAPK1IP1L Gene

Pathways & Interactions for MAPK1IP1L Gene

SuperPathways for MAPK1IP1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAPK1IP1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAPK1IP1L Gene

Drugs & Compounds for MAPK1IP1L Gene

No Compound Related Data Available

Transcripts for MAPK1IP1L Gene

Unigene Clusters for MAPK1IP1L Gene

Mitogen-activated protein kinase 1 interacting protein 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK1IP1L Gene

No ASD Table

Relevant External Links for MAPK1IP1L Gene

GeneLoc Exon Structure for
MAPK1IP1L
ECgene alternative splicing isoforms for
MAPK1IP1L

Expression for MAPK1IP1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAPK1IP1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPK1IP1L Gene

This gene is overexpressed in NK cells (10.8), Bone marrow stromal cell (9.7), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPK1IP1L Gene



NURSA nuclear receptor signaling pathways regulating expression of MAPK1IP1L Gene:

MAPK1IP1L

SOURCE GeneReport for Unigene cluster for MAPK1IP1L Gene:

Hs.594338

Evidence on tissue expression from TISSUES for MAPK1IP1L Gene

  • Nervous system(4.3)
  • Kidney(3.4)
  • Lung(2.9)
  • Skin(2.9)
  • Eye(2.3)
genes like me logo Genes that share expression patterns with MAPK1IP1L: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAPK1IP1L Gene

Orthologs for MAPK1IP1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAPK1IP1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK1IP1L 35 34
  • 99.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK1IP1L 35 34
  • 93.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK1IP1L 35 34
  • 93.17 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPK1IP1L 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk1ip1l 35 16 34
  • 85.06 (n)
OneToMany
Mapk1ip1 35
  • 41 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mapk1ip1l 34
  • 85.01 (n)
chicken
(Gallus gallus)
Aves MAPK1IP1L 34
  • 74.46 (n)
lizard
(Anolis carolinensis)
Reptilia MAPK1IP1L 35
  • 68 (a)
OneToOne
Species where no ortholog for MAPK1IP1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAPK1IP1L Gene

ENSEMBL:
Gene Tree for MAPK1IP1L (if available)
TreeFam:
Gene Tree for MAPK1IP1L (if available)

Paralogs for MAPK1IP1L Gene

Pseudogenes.org Pseudogenes for MAPK1IP1L Gene

genes like me logo Genes that share paralogs with MAPK1IP1L: view

No data available for Paralogs for MAPK1IP1L Gene

Variants for MAPK1IP1L Gene

Sequence variations from dbSNP and Humsavar for MAPK1IP1L Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000195504 -- 55,053,163(+) CTAAT(A/G)TTTGT intron-variant
rs1000926357 -- 55,051,870(+) GCCCG(C/T)GGGCG intron-variant
rs1001051329 -- 55,068,125(+) ATATA(C/T)TGATT utr-variant-3-prime
rs1001069852 -- 55,052,109(+) GGGCG(C/T)GGGCC intron-variant
rs1001126252 -- 55,062,029(+) AGATA(A/G)TAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK1IP1L Gene

Variant ID Type Subtype PubMed ID
nsv977468 CNV duplication 23825009

Variation tolerance for MAPK1IP1L Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK1IP1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK1IP1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK1IP1L Gene

Disorders for MAPK1IP1L Gene

Relevant External Links for MAPK1IP1L

Genetic Association Database (GAD)
MAPK1IP1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK1IP1L

No disorders were found for MAPK1IP1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPK1IP1L Gene

Publications for MAPK1IP1L Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
  5. Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate. (PMID: 12011110) Lefebvre C. … Verlhac M.H. (J. Cell Biol. 2002) 2 3 64

Products for MAPK1IP1L Gene

Sources for MAPK1IP1L Gene

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