MAPK1IP1L Gene
protein-coding GIFtS: 43
GCID: GC14P055518
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mitogen-activated protein kinase 1 interacting protein 1-like(Previous names: chromosome 14 open reading frame 32, mitogen activated...)
(Previous symbol: C14orf32)
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Aliases
for MAPK1IP1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitogen-Activated Protein Kinase 1 Interacting Protein 1-Like1 2 | | MISS2 | | C14orf321 2 3 | | C14_53461 | | Mitogen Activated Protein Kinase 1 Interacting Protein 1-Like1 2 | | MAPK-Interacting And Spindle-Stabilizing Protein2 | | Mitogen-Activated Protein Kinase 1-Interacting Protein 1-Like2 3 | | MAPK-Interacting And Spindle-Stabilizing Protein-Like2 | | Chromosome 14 Open Reading Frame 321 | | |
Export aliases for MAPK1IP1L gene to outside databasesPrevious GC identifers: GC14P054589 GC14P035680 |
Summaries
for MAPK1IP1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for MAPK1IP1L (C14orf32)
|
Genomic Views
for MAPK1IP1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAPK1IP1L gene promoter:
c-Fos AP-1 JunB Fra-1 FosB GATA-1 AREB6 JunD Chx10 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAPK1IP1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK1IP1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q22.3 Ensembl cytogenetic band: 14q22.3 HGNC cytogenetic band: 14q22.1MAPK1IP1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P055518: view genomic region
(about GC identifiers)
Start:
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55,518,349 bp from pter |
End:
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55,536,912 bp from pter |
Size:
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18,564 bases |
Orientation:
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plus strand |
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Proteins
for MAPK1IP1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MISSL_HUMAN, Q8NDC0 (See
protein sequence)Recommended Name: MAPK-interacting and spindle-stabilizing protein-like Size: 245 amino acids; 24269 Da
Secondary accessions: B2RDD8 Q96BG5Explore the universe of human proteins at neXtProt for MAPK1IP1L: NX_Q8NDC0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NDC0
MAPK1IP1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653179.1
ENSEMBL proteins: ENSP00000378851
Human Recombinant Protein Products:
MAPK1IP1L Antibody Products:
Assay Products for MAPK1IP1L: |
Protein
Domains /
Families
for MAPK1IP1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8NDC0 UniProtKB/Swiss-Prot: MISSL_HUMAN, Q8NDC0Similarity: Belongs to the MISS family |
Function
for MAPK1IP1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK1IP1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK1IP1L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MAPK1IP1L (NM_144578) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAPK1IP1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK1IP1L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK1IP1L |
3 GenomeRNAi human phenotypes for MAPK1IP1L:
|
Pathways & Interactions
for MAPK1IP1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAPK1IP1L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/14 Interacting proteins for MAPK1IP1L (Q8NDC02, 3 ENSP000003788514) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
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Drugs & Compounds
for MAPK1IP1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAPK1IP1L
Search CenterWatch for drugs/clinical trials and news about MAPK1IP1L / MISSL
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Transcripts
for MAPK1IP1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAPK1IP1L gene: NM_144578.3 Unigene Cluster for MAPK1IP1L: Mitogen-activated protein kinase 1 interacting protein 1-like Hs.594338 [show with all ESTs]Unigene Representative Sequence: NM_1445784 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000395468(uc001xbq.1) ENST00000554364 ENST00000556515 ENST00000553976
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK1IP1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK1IP1L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAPK1IP1L (NM_144578) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAPK1IP1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK1IP1L |
Additional cDNA sequence: AK025580.1 AK054650.1 AK096674.1 AK315501.1 AL834285.1 U90909.1 24/28 DOTS entries (see all 28): DT.100826952 DT.97818769 DT.119314 DT.100664507 DT.95093104 DT.120786438 DT.414579 DT.100762699 DT.100826954 DT.120786462 DT.120786848 DT.120786439 DT.120786527 DT.91761020 DT.95154261 DT.100719550 DT.100722116 DT.100779896 DT.120786668 DT.100826948 DT.100826955 DT.100831181 DT.101969624 DT.120786511 24/543 AceView cDNA sequences (see all 543): AI141807 AA825747 CR605386 H93567 BM559227 CA446502 AI368128 AW014813 AW768460 AA523593 AA669823 AI206783 BQ184981 AI128308 AI350626 CB105403 BM016510 BQ005076 CR623367 H83999 CK431027 R06089 AI275036 BQ026558
GeneLoc Exon Structure
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Expression
for MAPK1IP1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAPK1IP1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGTTCTCT
About this image
See MAPK1IP1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAPK1IP1L
SOURCE GeneReport for Unigene cluster: Hs.594338
SABiosciences Custom PCR Arrays for MAPK1IP1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPK1IP1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPK1IP1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK1IP1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK1IP1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK1IP1L |
Orthologs
for MAPK1IP1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for MAPK1IP1L gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for MAPK1IP1L (if available)
TreeFam Gene Tree for MAPK1IP1L (if available) |
Paralogs
for MAPK1IP1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAPK1IP1L gene
- CPSF72 SF3B42 CPSF62
MAPK1IP1L for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MAPK1IP1L
PGOHUM00000243723
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Genomic Variants
for MAPK1IP1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MAPK1IP1L (55518349 - 55536912 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAPK1IP1L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPK1IP1L |
|
Disorders
/ Diseases
for MAPK1IP1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAPK1IP1L for disorders About GeneDecksing
3  diseases for MAPK1IP1L: About MalaCardswiskott-aldrich syndrome tuberculosis mycobacterium tuberculosis
Export disorders for MAPK1IP1L gene to outside databases
|
Publications
for MAPK1IP1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAPK1IP1L gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with MAPK1IP1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate. (PubMed id 12011110)1, 3 Lefebvre C....Verlhac M.H. (2002)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
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External Searches for MAPK1IP1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MAPK1IP1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAPK1IP1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAPK1IP1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAPK1IP1L | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MAPK1IP1L gene:
Search GeneIP for patents involving MAPK1IP1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAPK1IP1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK1IP1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPK1IP1L | | | OriGene Protein Over-expression Lysate for MAPK1IP1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAPK1IP1L | | OriGene 3'-UTR Clone for MAPK1IP1L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK1IP1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK1IP1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | MAPK1IP1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK1IP1L |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK1IP1L |
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