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Aliases for MAPK15 Gene

Aliases for MAPK15 Gene

  • Mitogen-Activated Protein Kinase 15 2 3
  • Extracellular Signal Regulated Kinase 8 2 3
  • Extracellular Signal-Regulated Kinase 7 3 4
  • Extracellular Signal-Regulated Kinase 8 3 4
  • MAP Kinase 15 3 4
  • EC 2.7.11.24 4 64
  • MAPK 15 3 4
  • ERK-7 3 4
  • ERK-8 3 4
  • ERK7 3 4
  • ERK8 3 4
  • Extracellular Regulated Kinase 8 Delta 3
  • EC 2.7.11 64

External Ids for MAPK15 Gene

Summaries for MAPK15 Gene

GeneCards Summary for MAPK15 Gene

MAPK15 (Mitogen-Activated Protein Kinase 15) is a Protein Coding gene. Among its related pathways are mTOR Pathway and TNF Signaling. GO annotations related to this gene include SH3 domain binding and MAP kinase activity. An important paralog of this gene is MAPK1.

UniProtKB/Swiss-Prot for MAPK15 Gene

  • In vitro, phosphorylates MBP.

Gene Wiki entry for MAPK15 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK15 Gene

Genomics for MAPK15 Gene

Genomic Location for MAPK15 Gene

Start:
143,716,259 bp from pter
End:
143,722,463 bp from pter
Size:
6,205 bases
Orientation:
Plus strand

Genomic View for MAPK15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK15 Gene

Regulatory Elements for MAPK15 Gene

Proteins for MAPK15 Gene

  • Protein details for MAPK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD08-MK15_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 15
    Protein Accession:
    Q8TD08
    Secondary Accessions:
    • Q2TCF9
    • Q8N362

    Protein attributes for MAPK15 Gene

    Size:
    544 amino acids
    Molecular mass:
    59832 Da
    Quaternary structure:
    • Interacts with CSK/c-Src, ABL1, RET and TGFB1I1.

    Alternative splice isoforms for MAPK15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK15 Gene

Proteomics data for MAPK15 Gene at MOPED

Selected DME Specific Peptides for MAPK15 Gene

Post-translational modifications for MAPK15 Gene

  • Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro.
  • Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MAPK15 Gene

Gene Families for MAPK15 Gene

HGNC:
  • MAPK :Mitogen-activated protein kinase cascade / Kinases
IUPHAR :

Protein Domains for MAPK15 Gene

UniProtKB/Swiss-Prot:

MK15_HUMAN
Domain:
  • The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation.:
    • Q8TD08
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases:
    • Q8TD08
  • Contains 1 protein kinase domain.:
    • Q8TD08
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.:
    • Q8TD08
genes like me logo Genes that share domains with MAPK15: view

Function for MAPK15 Gene

Molecular function for MAPK15 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity).
UniProtKB/Swiss-Prot Function: In vitro, phosphorylates MBP.

Enzyme Numbers (IUBMB) for MAPK15 Gene

Gene Ontology (GO) - Molecular Function for MAPK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004707 MAP kinase activity IDA 11875070
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MAPK15: view
genes like me logo Genes that share phenotypes with MAPK15: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAPK15 Gene

Localization for MAPK15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK15 Gene COMPARTMENTS Subcellular localization image for MAPK15 gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2
cytosol 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAPK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 11875070
GO:0005622 intracellular NAS 11875070
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MAPK15: view

Pathways for MAPK15 Gene

genes like me logo Genes that share pathways with MAPK15: view

Pathways by source for MAPK15 Gene

2 Tocris pathways for MAPK15 Gene
1 Sino Biological pathway for MAPK15 Gene

Gene Ontology (GO) - Biological Process for MAPK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000165 MAPK cascade IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006468 protein phosphorylation --
GO:0008156 negative regulation of DNA replication IEA --
genes like me logo Genes that share ontologies with MAPK15: view

Compounds for MAPK15 Gene

(2) HMDB Compounds for MAPK15 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with MAPK15: view

Transcripts for MAPK15 Gene

Unigene Clusters for MAPK15 Gene

Mitogen-activated protein kinase 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK15 Gene

No ASD Table

Relevant External Links for MAPK15 Gene

GeneLoc Exon Structure for
MAPK15
ECgene alternative splicing isoforms for
MAPK15

Expression for MAPK15 Gene

mRNA expression in normal human tissues for MAPK15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK15 Gene

This gene is overexpressed in Fallopian Tube (6.0), Testis (4.9), Cervix - Endocervix (4.4), and Thyroid (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK15 Gene

SOURCE GeneReport for Unigene cluster for MAPK15 Gene Hs.493169

mRNA Expression by UniProt/SwissProt for MAPK15 Gene

Q8TD08-MK15_HUMAN
Tissue specificity: Widely expressed with a maximal expression in lung and kidney.
genes like me logo Genes that share expressions with MAPK15: view

Orthologs for MAPK15 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK15 36
  • 97.79 (n)
  • 97.02 (a)
MAPK15 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK15 36
  • 78.38 (n)
  • 72.37 (a)
MAPK15 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK15 36
  • 79.2 (n)
  • 73.15 (a)
MAPK15 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk15 36
  • 76.36 (n)
  • 72.42 (a)
Mapk15 16
Mapk15 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPK15 37
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK15 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk15 36
  • 75.98 (n)
  • 72.05 (a)
chicken
(Gallus gallus)
Aves MAPK15 36
  • 57.16 (n)
  • 52.09 (a)
MAPK15 37
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK15 37
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk15 36
  • 57.12 (n)
  • 52.54 (a)
zebrafish
(Danio rerio)
Actinopterygii mapk15 36
  • 55.56 (n)
  • 53.65 (a)
mapk15 37
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Erk7 36
  • 55.02 (n)
  • 47.89 (a)
Erk7 37
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C05D10.2 36
  • 55.27 (n)
  • 58.62 (a)
C05D10.2 37
  • 46 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8827 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
OneToOne
Species with no ortholog for MAPK15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK15 Gene

ENSEMBL:
Gene Tree for MAPK15 (if available)
TreeFam:
Gene Tree for MAPK15 (if available)

Paralogs for MAPK15 Gene

Paralogs for MAPK15 Gene

Selected SIMAP similar genes for MAPK15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAPK15: view

Variants for MAPK15 Gene

Sequence variations from dbSNP and Humsavar for MAPK15 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4072747 -- 143,718,721(+) CCCCC(C/G)AGGTT intron-variant
rs4875044 -- 143,719,903(+) GAGGG(C/T)GGGGG intron-variant
rs5895782 -- 143,719,178(+) CCCAA(-/C)CCCCC intron-variant
rs5895783 -- 143,721,049(+) TGCGG(-/C)CCCGG frameshift-variant, reference, intron-variant
rs6420190 -- 143,720,565(+) CCTGC(A/C)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK15 Gene

Variant ID Type Subtype PubMed ID
dgv7935n71 CNV Loss 21882294
dgv7938n71 CNV Loss 21882294
dgv7939n71 CNV Loss 21882294
dgv7940n71 CNV Loss 21882294
nsv891747 CNV Loss 21882294
nsv466007 CNV Loss 19166990
nsv519816 CNV Loss 19592680
nsv891751 CNV Loss 21882294
dgv7941n71 CNV Loss 21882294
nsv6441 CNV Insertion 18451855
nsv824777 CNV Loss 20364138
dgv7942n71 CNV Loss 21882294

Relevant External Links for MAPK15 Gene

HapMap Linkage Disequilibrium report
MAPK15

Disorders for MAPK15 Gene

No disorders were found for MAPK15 Gene.

No data available for UniProtKB/Swiss-Prot for MAPK15 Gene

Publications for MAPK15 Gene

  1. ERK8, a new member of the mitogen-activated protein kinase family. (PMID: 11875070) Abe M.K. … Rosner M.R. (J. Biol. Chem. 2002) 2 3 4 23
  2. Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. (PMID: 16484222) Iavarone C. … Chiariello M. (J. Biol. Chem. 2006) 3 4 23
  3. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5. (PMID: 16624805) Saelzler M.P. … Abe M.K. (J. Biol. Chem. 2006) 3 4 23
  4. Regulation of the activity and expression of ERK8 by DNA damage. (PMID: 19166846) Klevernic I.V. … Cohen P. (FEBS Lett. 2009) 3 23
  5. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. (PMID: 20395206) Xu Y.M. … Dong Z. (Cancer Res. 2010) 3 23

Products for MAPK15 Gene

Sources for MAPK15 Gene

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