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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK15 Gene

protein-coding   GIFtS: 54
GCID: GC08P144798

mitogen-activated protein kinase 15
 Explore 2 diseases affiliated with
MAPK15 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAPK15    

Aliases
for MAPK15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase 151 2     MAP Kinase 152 3
ERK71 2 3     MAPK 152 3
ERK81 2 3     EC 2.7.11.243 8
Extracellular Signal-Regulated Kinase 72 3     Extracellular Regulated Kinase 8 Delta2
Extracellular Signal-Regulated Kinase 82 3     Extracellular Signal Regulated Kinase 82
ERK-72 3     EC 2.7.118
ERK-82 3     

External Ids:    HGNC: 246671   Entrez Gene: 2256892   Ensembl: ENSG000001810857   UniProtKB: Q8TD083   

Export aliases for MAPK15 gene to outside databases

Previous GC identifers: GC08P144871 GC08P140051


Summaries
for MAPK15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MK15_HUMAN, Q8TD08
Function: In vitro, phosphorylates MBP

Gene Wiki entry for MAPK15


Genomic Views
for MAPK15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK15 gene promoter:
         AP-1   ATF-2   Lmo2   RelA   E2F   AP-2beta   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAPK15 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

MAPK15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK15 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P144798:  view genomic region     (about GC identifiers)

Start:
 144,798,429 bp from pter      End:
 144,804,633 bp from pter
Size:
 6,205 bases      Orientation:
 plus strand

1 alternative location:
Chr8+,PATCHES 144,784,872-144,790,998     

Proteins
for MAPK15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MK15_HUMAN, Q8TD08 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 15  
Size: 544 amino acids; 59832 Da
Subunit: Interacts with CSK/c-Src, ABL1, RET and TGFB1I1
Secondary accessions: Q2TCF9 Q8N362
Alternative splicing: 3 isoforms:  Q8TD08-1   Q8TD08-2   Q8TD08-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAPK15: NX_Q8TD08

Post-translational modifications:

  • Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine
    • residues in vitro1
  • Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated
    • by a SCF E3 ligase (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TD08

    • 4 DME Specific Peptides for MAPK15 (Q8TD08)
     GRPLFPG  YVATRWYR  TRWYRAPE  TEYVATRWYRAPE 

    MAPK15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_620590.2  
    ENSEMBL proteins: 
     ENSP00000337691   ENSP00000378539   ENSP00000378540  

    Human Recombinant Protein Products: 
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    Novus Biologicals MAPK15 Proteins
    Novus Biologicals MAPK15 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAPK15

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11875070
    GO:0005622intracellular NAS11875070
    GO:0005634nucleus IEA--


    MAPK15 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MAPK15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPK15 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8TD08

    ProtoNet protein and cluster: Q8TD08

    1 Blocks protein family: IPB003527 MAP kinase

    UniProtKB/Swiss-Prot: MK15_HUMAN, Q8TD08
    Domain: The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal
    degradation (By similarity)
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAPK15 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MK15_HUMAN, Q8TD08
    Function: In vitro, phosphorylates MBP
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases,
    such as DUSP1 (By similarity)

    Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK15
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for MAPK15

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004707MAP kinase activity IDA11875070
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0017124SH3 domain binding NAS11875070
    GO:0030528transcription regulator activity ----


    MAPK15 for ontologies           About GeneDecksing


    7 GenomeRNAi human phenotypes for MAPK15:
     Decreased 12E8 and total tau p  Decreased telomerase activity  Increased apoptosis  Increased cell death HMECs cel 
     Increased cell number in G2M,   Upregulation of NF-kappaB path  Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for MAPK15 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Toll-like Receptor Pathway
    		Toll-like Receptor Pathway1.00
    2mTOR Pathway
    		Insulin Pathway0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Tocris Bioscience Pathways for MAPK15
        Insulin Pathway
    Toll-like Receptor Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for MAPK15 (Q8TD083 ENSP000003376914) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSKP412403, ENSP000002200034I2D: score=1 STRING: ENSP00000220003
    NR3C1P041503, ENSP000002315094I2D: score=1 STRING: ENSP00000231509
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    MBPP026863, ENSP000003482734I2D: score=1 STRING: ENSP00000348273
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000165MAPK cascade IDA11875070
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0006468protein phosphorylation ----
    GO:0008156negative regulation of DNA replication IEA--


    MAPK15 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPK15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for MAPK15:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAPK15

    2 HMDB Compounds for MAPK15    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Search CenterWatch for drugs/clinical trials and news about MAPK15 / MK15 

    Transcripts
    for MAPK15 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPK15 gene: 
    NM_139021.2  

    Unigene Cluster for MAPK15:

    Mitogen-activated protein kinase 15
    Hs.493169  [show with all ESTs]
    Unigene Representative Sequence: NM_139021
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338033(uc003yzj.3) ENST00000484654 ENST00000475376 ENST00000395107
    ENST00000395108 ENST00000533830 ENST00000461928 ENST00000528175

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AY065978.1 AY994058.1 

    5 DOTS entries:

    DT.95335930  DT.92068815  DT.92022959  DT.104136  DT.120636457 

    24/38 AceView cDNA sequences (see all 38):

    AI049667 NM_139021 AI476756 BM553342 BP357805 BM701639 BC028034 BE464560 
    AL537138 BX451505 AA557536 BU675418 BU150340 CB250525 BX442126 BX451569 
    AY065978 AA284718 AW189633 AI680380 AJ403115 BF746633 AI921266 BI916334 

    GeneLoc Exon Structure


    Expression
    for MAPK15 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGCCCCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPK15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMedulla OblongataBrain
    KidneyMetanephrosKidney
    Neural TubeDiencephalonNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See MAPK15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK15

    SOURCE GeneReport for Unigene cluster: Hs.493169

    UniProtKB/Swiss-Prot: MK15_HUMAN, Q8TD08
    Tissue specificity: Widely expressed with a maximal expression in lung and kidney

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    In Situ
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    Orthologs
    for MAPK15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAPK15 gene from 5/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAPK151 mitogen-activated protein kinase 15 57.48(n)
    52.47(a)    		   426292  XM_423954.3  XP_423954.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPK156
    		 --
    		 37(a)
    		 1 ↔ 1
    		 GL343931.1(22683-35768)
    zebrafish
    (Danio rerio)    		 Actinopterygii mapk151 mitogen-activated protein kinase 15 57.06(n)
    55.07(a)    		   553780  NM_001020745.1  NP_001018581.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG327031 CG32703 52.06(n)
    42.02(a)    		   31877  NM_001201639.1  NP_001188568.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C05D10.21 Protein C05D10.2 51.32(n)
    51.4(a)    		   175857  NM_171144.3  NP_741165.1 


    ENSEMBL Gene Tree for MAPK15 (if available)
    TreeFam Gene Tree for MAPK15 (if available) 

    Paralogs
    for MAPK15 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK15 gene
    MAPK42  MAPK32  MAPK72  NLK2  MAPK62  MAPK12  
    18/23 SIMAP similar genes for MAPK15 using alignment to 1 protein entry:     MK15_HUMAN(see all similar genes):
    DKFZp686O0215    MAPK3    MAPK1    CDK3    CDK2    MAPK13
    CDK7    MAPK11    MAPK14    CDK1    MAPK12    CDK10
    NLK    PCTK1    CDK5    CDK4    CDK6    CDKL4

    MAPK15 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPK15 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/233 NCBI SNPs in MAPK15 are shown (see all 233)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs58957821,2
    		C,--140054158(+) CCCAA-/CCCCCC 1 -- int1 trp31Minor allele frequency- C:0.00NA 2
    rs1894354851,2
    		--144796573(+) GAAATC/GGAGAC 1 -- us2k10--------
    rs132749221,2
    		C,A,--144796604(+) AACCCT/CGTCTC 1 -- us2k12Minor allele frequency- C:0.25NA 4
    rs1815504451,2
    		--144796801(+) GCGCGC/GTGGCT 1 -- us2k10--------
    rs1844790401,2
    		--144796873(+) CGGCCA/GCTGTG 1 -- us2k10--------
    rs74651151,2
    		C,--144796922(+) CTTTTT/CTGTCT 1 -- us2k15Minor allele frequency- C:0.10NA 10
    rs1889845611,2
    		--144796950(+) TCGACA/CTTAAA 1 -- us2k10--------
    rs726140471,2
    		C,F,--144796967(+) TTTTTA/GGTTAA 1 -- us2k13Minor allele frequency- G:0.14WA NA EA 358
    rs715160341,2
    		C--144797322(+) TTTTTTT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1811079501,2
    		--144797483(+) ACGGCA/GCCCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPK15 (144798429 - 144804633 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAPK15: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPK15
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK15

    Disorders / Diseases
    for MAPK15 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPK15 for disorders           About GeneDecksing

    2 diseases for MAPK15:    About MalaCards
    colon cancer    malaria


    Export disorders for MAPK15 gene to outside databases

    Publications
    for MAPK15 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK15 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with MAPK15)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ERK8, a new member of the mitogen-activated protein kinase family. (PubMed id 11875070)1, 2, 3, 9 Abe M.K.... Rosner M.R. (2002)
    2. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5. (PubMed id 16624805)1, 2, 9 Saelzler M.P....Abe M.K. (2006)
    3. Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. (PubMed id 16484222)1, 2, 9 Iavarone C.... Chiariello M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Extracellular signal-regulated kinase 8-mediated c-Ju n phosphorylation increases tumorigenesis of human colon cancer. (PubMed id 20395206)1, 9 Xu Y.M....Dong Z. (2010)
    6. Regulation of the activity and expression of ERK8 by DNA damage. (PubMed id 19166846)1, 9 Klevernic I.V....Cohen P. (2009)
    7. Extracellular signal-regulated kinase 8 (ERK8) contro ls estrogen-related receptor I+ (ERRI+) cellular localization and inhibits its tr anscriptional activity. (PubMed id 21190936)1 Rossi M....Chiariello M. (2011)
    8. A chromatin-bound kinase, ERK8, protects genomic inte grity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA. (PubMed id 20733054)1 Groehler A.L. and Lannigan D.A. (2010)
    9. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    External Searches for MAPK15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MAPK15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 225689 HGNC: 24667 AceView: ERK8 Ensembl:ENSG00000181085 euGenes: HUgn225689
    ECgene: MAPK15 H-InvDB: MAPK15

    Other Databases showing MAPK15 gene

    (According to HUGE)
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    		   --

    Specialized Databases showing MAPK15 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK15 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAPK15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPK15 gene:
    Search GeneIP for patents involving MAPK15

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