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MAPK15 Gene

protein-coding   GIFtS: 56
GCID: GC08P144798

Mitogen-Activated Protein Kinase 15

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 151 2     ERK82 3
Extracellular Signal Regulated Kinase 81 2     MAP Kinase 152 3
Extracellular Signal-Regulated Kinase 72 3     MAPK 152 3
Extracellular Signal-Regulated Kinase 82 3     EC 2.7.11.243 8
ERK-72 3     Extracellular Regulated Kinase 8 Delta2
ERK-82 3     EC 2.7.118
ERK72 3     

External Ids:    HGNC: 246671   Entrez Gene: 2256892   Ensembl: ENSG000001810857   UniProtKB: Q8TD083   

Export aliases for MAPK15 gene to outside databases

Previous GC identifers: GC08P144871 GC08P140051


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAPK15 Gene:
MAPK15 (mitogen-activated protein kinase 15) is a protein-coding gene. Diseases associated with MAPK15 include obesity. GO annotations related to this gene include MAP kinase activity and SH3 domain binding. An important paralog of this gene is MAPK4.

UniProtKB/Swiss-Prot: MK15_HUMAN, Q8TD08
Function: In vitro, phosphorylates MBP

Gene Wiki entry for MAPK15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NT_187571.1  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK15 gene promoter:
         AP-1   ATF-2   Lmo2   RelA   E2F   AP-2beta   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPK15 promoter sequence
   Search Chromatin IP Primers for MAPK15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

MAPK15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK15 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P144798:  view genomic region     (about GC identifiers)

Start:
144,798,429 bp from pter      End:
144,804,633 bp from pter
Size:
6,205 bases      Orientation:
plus strand

1 alternative location:
Chr8+,NW_003315923 54,982-61,108     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MK15_HUMAN, Q8TD08 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 15  
Size: 544 amino acids; 59832 Da
Subunit: Interacts with CSK/c-Src, ABL1, RET and TGFB1I1
Secondary accessions: Q2TCF9 Q8N362
Alternative splicing: 3 isoforms:  Q8TD08-1   Q8TD08-2   Q8TD08-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAPK15: NX_Q8TD08

Explore proteomics data for MAPK15 at MOPED

Post-translational modifications: 

  • Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and
    tyrosine residues in vitro1
  • Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be
    ubiquitinated by a SCF E3 ligase (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for MAPK15 (Q8TD08)
     GRPLFPG  YVATRWYR  TRWYRAPE  TEYVATRWYRAPE 


    See MAPK15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_620590.2  
    ENSEMBL proteins: 
     ENSP00000337691   ENSP00000378539   ENSP00000378540  

    MAPK15 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MAPK15

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    MAPK15 Assay Products:

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    Cloud-Clone Corp. CLIAs for MAPK15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 15
    Erk7 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8TD08

    ProtoNet protein and cluster: Q8TD08

    1 Blocks protein domain: IPB003527 MAP kinase

    UniProtKB/Swiss-Prot: MK15_HUMAN, Q8TD08
    Domain: The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal
    degradation (By similarity)
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK15_HUMAN, Q8TD08
    Function: In vitro, phosphorylates MBP
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity
    phosphatases, such as DUSP1 (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004707MAP kinase activity IDA11875070
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    MAPK15 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for MAPK15:
     Decreased 12E8 and total tau p  Decreased telomerase activity  Increased apoptosis  Increased cell death HMECs cel 
     Increased cell number in G2M,   Upregulation of NF-kappaB path  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK15
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK15
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    Predesigned siRNA for gene silencing in human, mouse, rat MAPK15

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK15 (NM_139021)
    Sino Biological Human cDNA Clone for MAPK15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK15

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    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK15 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion2
    nucleus2
    cytosol1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11875070
    GO:0005622intracellular NAS11875070
    GO:0005634nucleus IEA--

    MAPK15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK15 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    2MAPK Pathway
    Toll-like Receptor Pathway0.36
    3mTOR Pathway
    Insulin Pathway0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Tocris Bioscience Pathways for MAPK15
        Insulin Pathway
    Toll-like Receptor Pathway

    1 Sino Biological Pathway for MAPK15
        TNF Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAPK15
    Interactions:

        GeneGlobe Interaction Network for MAPK15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK15 (Q8TD083 ENSP000003376914) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSKP412403, ENSP000002200034I2D: score=1 STRING: ENSP00000220003
    NR3C1P041503, ENSP000002315094I2D: score=1 STRING: ENSP00000231509
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    MBPP026863, ENSP000003482734I2D: score=1 STRING: ENSP00000348273
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000165MAPK cascade IDA11875070
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0006468protein phosphorylation ----
    GO:0008156negative regulation of DNA replication IEA--

    MAPK15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPK15 (MK15)

    2 HMDB Compounds for MAPK15    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAPK15 gene: 
    NM_139021.2  

    Unigene Cluster for MAPK15:

    Mitogen-activated protein kinase 15
    Hs.493169  [show with all ESTs]
    Unigene Representative Sequence: NM_139021
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338033(uc003yzj.3) ENST00000484654 ENST00000475376 ENST00000395107
    ENST00000395108 ENST00000533830 ENST00000461928 ENST00000528175
    miRNA
    Products:
         
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    SwitchGear 3'UTR luciferase reporter plasmidMAPK15 3' UTR sequence
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK15
      QuantiTect SYBR Green Assays in human, mouse, rat MAPK15
      QuantiFast Probe-based Assays in human, mouse, rat MAPK15

    Additional mRNA sequence: 

    AY065978.1 AY994058.1 

    5 DOTS entries:

    DT.95335930  DT.92068815  DT.92022959  DT.104136  DT.120636457 

    Selected AceView cDNA sequences (see all 38):

    BM701639 AI049667 BC028034 NM_139021 BM553342 BP357805 BE464560 AI476756 
    BX451569 AA557536 BU675418 CB250525 BU150340 BX442126 AL537138 BX451505 
    AY065978 AI680380 AJ403115 BF746633 AA284718 AW189633 BF747333 AI921266 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPK15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCCCCCA
    MAPK15 Expression
    About this image


    MAPK15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Kidney (Urinary System)
             Metanephros
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Brain (Nervous System)
             Medulla Oblongata
    MAPK15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.493169

    UniProtKB/Swiss-Prot: MK15_HUMAN, Q8TD08
    Tissue specificity: Widely expressed with a maximal expression in lung and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAPK15 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk151 , 5 mitogen-activated protein kinase 151, 5 76.36(n)1
    72.42(a)1
      15 (35.20 cM)5
    3321101  NM_177922.21  NP_808590.11 
     759937695 
    chicken
    (Gallus gallus)
    Aves MAPK151 mitogen-activated protein kinase 15 57.16(n)
    52.09(a)
      426292  XM_004940096.1  XP_004940153.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK156
    mitogen-activated protein kinase 15
    41(a)
    1 ↔ 1
    GL343931.1(22683-35780)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mapk151 mitogen-activated protein kinase 15 57.12(n)
    52.54(a)
      100145558  NM_001126989.1  NP_001120461.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapk151 mitogen-activated protein kinase 15 55.56(n)
    53.65(a)
      553780  NM_001020745.1  NP_001018581.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Erk71 Extracellularly regulated kinase 7 55.02(n)
    47.89(a)
      31877  NM_001201640.1  NP_001188569.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C05D10.21 C05D10.2 55.27(n)
    58.62(a)
      175857  NM_171144.4  NP_741165.1 


    ENSEMBL Gene Tree for MAPK15 (if available)
    TreeFam Gene Tree for MAPK15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK15 gene
    MAPK42  MAPK32  MAPK72  NLK2  MAPK62  MAPK12  
    Selected SIMAP similar genes for MAPK15 using alignment to 1 protein entry:     MK15_HUMAN(see all similar genes):
    DKFZp686O0215    MAPK3    MAPK1    CDK3    CDK2    MAPK13
    CDK7    MAPK11    MAPK14    CDK1    MAPK12    CDK10
    NLK    PCTK1    CDK5    CDK4    CDK6    CDKL4

    MAPK15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPK15 (see all 384)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894354851,2
    --144796573(+) GAAATC/GGAGAC 1 -- us2k10--------
    rs132749221,2
    C,A--144796604(+) aacccT/Cgtctc 1 -- us2k12Minor allele frequency- C:0.25NA 4
    rs1815504451,2
    C--144796801(+) GCGCGC/GTGGCT 1 -- us2k10--------
    rs1844790401,2
    --144796873(+) CGGCCA/GCTGTG 1 -- us2k10--------
    rs74651151,2
    C--144796922(+) CTTTTT/CTGTCT 1 -- us2k15Minor allele frequency- C:0.10NA 10
    rs1889845611,2
    --144796950(+) TCGACA/CTTAAA 1 -- us2k10--------
    rs726140471,2
    C,F--144796967(+) TTTTTA/GGTTAA 1 -- us2k13Minor allele frequency- G:0.14WA NA EA 358
    rs715160341,2
    C--144797331(+) TTTTTTT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1811079501,2
    --144797483(+) ACGGCA/GCCCAC 1 -- us2k10--------
    rs1864701481,2
    --144797560(+) GTCTCA/GATCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPK15 (144798429 - 144804633 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAPK15 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6441CNV Insertion18451855
    nsv891751CNV Loss21882294
    nsv891747CNV Loss21882294
    dgv7942n71CNV Loss21882294
    dgv7939n71CNV Loss21882294
    dgv7941n71CNV Loss21882294
    nsv466007CNV Loss19166990
    dgv7935n71CNV Loss21882294
    nsv519816CNV Loss19592680
    dgv7940n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for MAPK15:    
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    obesity


    MAPK15 for disorders           About GeneDecksing


    Export disorders for MAPK15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK15 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with MAPK15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ERK8, a new member of the mitogen-activated protein kinase family. (PubMed id 11875070)1, 2, 3, 9 Abe M.K.... Rosner M.R. (J. Biol. Chem. 2002)
    2. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5. (PubMed id 16624805)1, 2, 9 Saelzler M.P....Abe M.K. (J. Biol. Chem. 2006)
    3. Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. (PubMed id 16484222)1, 2, 9 Iavarone C.... Chiariello M. (J. Biol. Chem. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. (PubMed id 20395206)1, 9 Xu Y.M....Dong Z. (Cancer Res. 2010)
    6. Regulation of the activity and expression of ERK8 by DNA damage. (PubMed id 19166846)1, 9 Klevernic I.V....Cohen P. (FEBS Lett. 2009)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Structure prediction and validation of the ERK8 kinase domain. (PubMed id 23326322)1 Strambi A....Chiariello M. (PLoS ONE 2013)
    10. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 225689 HGNC: 24667 AceView: ERK8 Ensembl:ENSG00000181085 euGenes: HUgn225689
    ECgene: MAPK15 H-InvDB: MAPK15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPK15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPK15 gene:
    Search GeneIP for patents involving MAPK15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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