Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK14 Gene

protein-coding   GIFtS: 76
GCID: GC06P035995

Mitogen-Activated Protein Kinase 14


(Previous symbols: CSPB1, CSBP1, CSBP2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase 141 2     EXIP2
CSBP11 2 3 5     Mxi22
CSBP21 2 3     PRKM142
CSPB11 2 3     PRKM152
P38 MAP Kinase1 2     RK2
Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein2 3     Csaids Binding Protein2
MAP Kinase MXI22 3     Cytokine Suppressive Anti-Inflammatory Drug Binding Protein2
Mitogen-Activated Protein Kinase P38 Alpha2 3     p382
Stress-Activated Protein Kinase 2a2 3     P38 Mitogen Activated Protein Kinase2
CSBP2 3     p38ALPHA2
SAPK2A2 3     P38alpha Exip2
CSAID-Binding Protein2 3     MXI23
MAP Kinase 142 3     SAPK2a3
MAP Kinase P38 Alpha2 3     MAPK 143
MAX-Interacting Protein 22 3     EC 2.7.118
EC 2.7.11.243 8     

External Ids:    HGNC: 68761   Entrez Gene: 14322   Ensembl: ENSG000001120627   OMIM: 6002895   UniProtKB: Q165393   

Export aliases for MAPK14 gene to outside databases

Previous GC identifers: GC06P035997 GC06P036042 GC06P036103 GC06P035715


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPK14 Gene:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. This kinase is activated by various environmental
stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs),
or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The
substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and
tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle
regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene
encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPK14 Gene: 
MAPK14 (mitogen-activated protein kinase 14) is a protein-coding gene. Diseases associated with MAPK14 include doxorubicin induced cardiomyopathy, and alexander disease, and among its related super-pathways are MAPK Cascade and Development FGF-family signaling. GO annotations related to this gene include MAP kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is MAPK9.

UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been
estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases
which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and
RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B
isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1.
RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to
stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription
machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control
of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and
ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and
MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the
initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through
autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an
important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose
proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates
the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal
degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein
ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms
that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by
inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of
RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to
inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such
phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in
the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be
translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes
such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many
transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical
examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging
as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of
several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent
enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This
phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for
increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3
proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA
damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have
kinase-independent roles, which are thought to be due to the binding to targets in the absence of
phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does
not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose
deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as
neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of
embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in
developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2
activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform
EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'

summary for MAPK14 Gene:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK14 gene promoter:
         MEF-2A   AP-1   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MAPK14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3-p21.2   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.3-p21.2

MAPK14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK14 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P035995:  view genomic region     (about GC identifiers)

Start:
35,995,454 bp from pter      End:
36,079,013 bp from pter
Size:
83,560 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 14  
Size: 360 amino acids; 41293 Da
Cofactor: Magnesium
Subunit: Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This
interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with
SPAG9 and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1.
Interacts with casein kinase II subunits CSNK2A1 and CSNK2B
Subcellular location: Cytoplasm. Nucleus
6/200 PDB 3D structures from and Proteopedia for MAPK14 (see all 200):
1A9U (3D)        1BL6 (3D)        1BL7 (3D)        1BMK (3D)        1DI9 (3D)        1IAN (3D)    
Secondary accessions: A6ZJ92 A8K6P4 B0LPH0 O60776 Q13083 Q14084 Q8TDX0
Alternative splicing: 4 isoforms:  Q16539-1   Q16539-2   Q16539-3   Q16539-4   

Explore the universe of human proteins at neXtProt for MAPK14: NX_Q16539

Explore proteomics data for MAPK14 at MOPED 

Post-translational modifications:

  • UniProtKB: Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to
    inflammatory citokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation
    can also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323
    phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP16
  • UniProtKB: Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and
    enhances kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC3
  • UniProtKB: Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16539

  • 4/34 DME Specific Peptides for MAPK14 (Q16539) (see all 34)
     LKYIHSA  DTKTGLR  AHAYFAQ  FVPPPLD 

    MAPK14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAPK14 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001306.1  NP_620581.1  NP_620582.1  NP_620583.1  

    ENSEMBL proteins: 
     ENSP00000229795   ENSP00000229794   ENSP00000419837   ENSP00000417531   ENSP00000308669  
     ENSP00000417065   ENSP00000419141  
    Reactome Protein details: Q16539
    Human Recombinant Protein Products for MAPK14: 
    EMD Millipore Purified and/or Recombinant MAPK14 Protein
    R&D Systems Recombinant & Natural Proteins for MAPK14 (p38 alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MAPK14
    OriGene Protein Over-expression Lysate for MAPK14
    OriGene MassSpec for MAPK14 
    OriGene Custom Protein Services for MAPK14
    GenScript Custom Purified and Recombinant Proteins Services for MAPK14
    Novus Biologicals MAPK14 Proteins
    Novus Biologicals MAPK14 Lysates
    Sino Biological Recombinant Protein for MAPK14
    Sino Biological Cell Lysate for MAPK14 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAPK14 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005623cell ----
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ISS--

    MAPK14 for ontologies           About GeneDecksing



    MAPK14 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK14
    R&D Systems Antibodies for MAPK14 (p38 alpha)
    Cell Signaling Technology (CST) Antibodies for MAPK14  (P38A)
    OriGene Antibodies for MAPK14
    OriGene Custom Antibody Services for MAPK14
    GenScript Custom Superior Antibodies Services for MAPK14
    Novus Biologicals MAPK14 Antibodies
    Abcam antibodies for MAPK14
    Cloud-Clone Corp. Antibodies for MAPK14 
    ThermoFisher Antibody for MAPK14
    LSBio Antibodies in human, mouse, rat for MAPK14 

    Assay Products for MAPK14: 
    EMD Millipore Kits and Assays for the Analysis of MAPK14
    OriGene Custom Assay Services for MAPK14
    R&D Systems ELISAs for MAPK14 (p38 alpha)         (see all)
    GenScript Custom Assay Services for MAPK14
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK14 (P38A)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK14 
    Cloud-Clone Corp. CLIAs for MAPK14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 14 
    p38 subfamily
    Mitogen-activated protein kinases

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q16539

    ProtoNet protein and cluster: Q16539

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK14_HUMAN, Q16539
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
    evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
    of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been
    estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases
    which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and
    RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B
    isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1.
    RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to
    stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription
    machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control
    of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and
    ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and
    MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the
    initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through
    autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an
    important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose
    proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates
    the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal
    degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein
    ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms
    that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by
    inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of
    RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to
    inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such
    phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in
    the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be
    translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes
    such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many
    transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical
    examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging
    as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of
    several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent
    enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This
    phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for
    increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3
    proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA
    damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have
    kinase-independent roles, which are thought to be due to the binding to targets in the absence of
    phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does
    not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose
    deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as
    neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of
    embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in
    developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2
    activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform
    EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by cell stresses such as DNA damage, heat shock, osmotic shock, anisomycin and sodium
    arsenite, as well as pro-inflammatory stimuli such as bacterial lipopolysaccharide (LPS) and interleukin-1.
    Activation occurs through dual phosphorylation of Thr-180 and Tyr-182 by either of two dual specificity kinases,
    MAP2K3/MKK3 or MAP2K6/MKK6, and potentially also MAP2K4/MKK4, as well as by TAB1-mediated autophosphorylation.
    MAPK14 phosphorylated on both Thr-180 and Tyr-182 is 10-20-fold more active than MAPK14 phosphorylated only on
    Thr-180, whereas MAPK14 phosphorylated on Tyr-182 alone is inactive. whereas Thr-180 is necessary for catalysis,
    Tyr-182 may be required for auto-activation and substrate recognition. Phosphorylated at Tyr-323 by ZAP70 in an
    alternative activation pathway in response to TCR signaling in T-cells. This alternative pathway is inhibited by
    GADD45A. Inhibited by dual specificity phosphatases, such as DUSP1, DUSP10, and DUSP16. Specifically inhibited by
    the binding of pyridinyl-imidazole compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID).
    Isoform Mxi2 is 100-fold less sensitive to these agents than the other isoforms and is not inhibited by DUSP1.
    Isoform Exip is not activated by MAP2K6. SB203580 is an inhibitor of MAPK14

         Genatlas biochemistry entry for MAPK14:
    mitogen-activated protein kinase14

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004707MAP kinase activity IDA10330143
    GO:0004708MAP kinase kinase activity TAS10706854
    GO:0004713protein tyrosine kinase activity ----
         
    MAPK14 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAPK14:
     Decreased number of cells in m  Decreased substrate adherent c  Decreased telomerase activity  Decreased viability after Chla 
     High actin ratio cells 

         15/18 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Mapk14) (see all 18):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  muscle  nervous system  normal  reproductive system 

    MAPK14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAPK14: Mapk14tm1Mms Mapk14tm1Gab Mapk14tm1Mka Mapk14tm1.1Otsu

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAPK14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAPK14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK14 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPK14:
    hsa-mir-124 (MIRT002610), hsa-mir-24 (MIRT002950)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK14
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK14 (see all 46):
    hsa-miR-124* hsa-miR-3616-5p hsa-miR-128 hsa-miR-16-1* hsa-miR-3142 hsa-miR-124 hsa-miR-629* hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidMAPK14 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAPK14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK14
    Sirion Biotech Customized adenovirus for overexpression of MAPK14

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAPK14 (see all 29)
    OriGene ORF clones in mouse, rat for MAPK14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK14 (NM_139012)
    Sino Biological Human cDNA Clone for MAPK14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK14
    Sirion Biotech Customized lentivirus for stable overexpression of MAPK14 
                         Customized lentivirus expression plasmids for stable overexpression of MAPK14 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK14
    Search LifeMap BioReagents cell lines for MAPK14
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAPK14 About   (see all 171)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1G-protein signaling Ras family GTPases in kinase cascades (scheme)
    G-protein signaling Ras family GTPases in kinase cascades (scheme)0.44
    Oncostatin M Signaling Pathway0.37
    MAPK Cascade0.44
    Activation of the AP-1 family of transcription factors0.33
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Rapid glucocorticoid signaling0.31
    2Development FGF-family signaling
    Development FGF-family signaling0.63
    Development Flt3 signaling0.45
    Development FGFR signaling pathway0.50
    FGF Pathway0.38
    3B cell receptor signaling pathway
    BCR signaling pathway0.42
    TCR Signaling Pathway0.35
    T cell receptor signaling pathway0.38
    4Toll Comparative Pathway
    Toll Comparative Pathway0.61
    Immune response IL-1 signaling pathway0.41
    TLR-TRIF Pathway0.61
    IL-1 Pathway0.39
    Immune response MIF in innate immunity response0.46
    iNOS Signaling0.34
    5BAFF in B-Cell Signaling
    BAFF in B-Cell Signaling0.92
    RANK Signaling in Osteoclasts0.45
    APRIL Pathway0.92
    RANKL/RANK Signaling Pathway0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/29 EMD Millipore Pathways for MAPK14 (see all 29)
        Development A1 receptor signaling
    Immune response MIF in innate immunity response
    G-protein signaling G-Protein alpha-12 signaling pathway
    Development TGF-beta receptor signaling
    Immune response CCR3 signaling in eosinophils

    5/7 R&D Systems Pathways for MAPK14 (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/94 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK14 (see all 94)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK14
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK14
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    5/32 GeneGo (Thomson Reuters) Pathways for MAPK14 (see all 32)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    Development Endothelin-1/EDNRA signaling
    Immune response IL-12-induced IFN-gamma production

    5/63 BioSystems Pathways for MAPK14 (see all 63)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Senescence and Autophagy
    EGFR1 Signaling Pathway
    Insulin Signaling

    5 Sino Biological Pathways for MAPK14 
        TNF Signaling
    Non-Canonical Wnt Pathway
    p53 Pathway
    VEGF Signaling
    TGF-beta Signaling Pathway

    5/50        Reactome Pathways for MAPK14 (see all 50)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Platelet homeostasis
    p38MAPK events
    Toll Like Receptor 3 (TLR3) Cascade

    2 PharmGKB Pathways for MAPK14
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/29         Kegg Pathways  (Kegg details for MAPK14) (see all 29):
        MAPK signaling pathway
    VEGF signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway


    MAPK14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/451 Interacting proteins for MAPK14 (Q165391, 2, 3 ENSP000002297944) via UniProtKB, MINT, STRING, and/or I2D (see all 451)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273611, 2, 3, ENSP000002630254EBI-73946,EBI-73995 MINT-8092346 MINT-8092357 MINT-8092337 I2D: score=5 STRING: ENSP00000263025
    ZFP36L1Q073521, 2, 3, ENSP000003373864EBI-73946,EBI-721823 MINT-66629 I2D: score=6 STRING: ENSP00000337386
    SUPT20HQ8NEM71, 2, 3, ENSP000002188944EBI-73946,EBI-946984 MINT-7557407 I2D: score=5 STRING: ENSP00000218894
    TAB1Q157502, 3, ENSP000002161604MINT-17883 MINT-8260174 MINT-17884 I2D: score=5 STRING: ENSP00000216160
    DUSP9Q999562, 3, ENSP000003458534MINT-8287227 MINT-8287259 MINT-8287212 I2D: score=2 STRING: ENSP00000345853
    About this table

    Gene Ontology (GO): 5/67 biological process terms (GO ID links to tree view) (see all 67):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IEA--
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity TAS--
    GO:0000902cell morphogenesis IEA--
    GO:0001525angiogenesis IEA--

    MAPK14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK14 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK14:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MAPK14 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 239063 Potent, selective p38 MAPK inhibitor; orally active [193551-21-2]
    SB 202190 Potent, selective inhibitor of p38 MAPK [152121-30-7]
    SB 203580 hydrochlorideSelective inhibitor of p38 MAPK; water-soluble[152121-47-6]
    SB 203580Selective inhibitor of p38 MAPK[152121-47-6]
    SCIO 469 hydrochlorideSelective p38 MAPK inhibitor[309913-83-5]

    3 HMDB Compounds for MAPK14    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    10/50 DrugBank Compounds for MAPK14 (see all 50)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One-- --target--17139284 17016423 10592235
    1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea-- --target--17139284 17016423 10592235
    3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine-- --target--17139284 17016423 10592235
    3-(Benzyloxy)Pyridin-2-Amine-- --target--17139284 17016423 10592235
    4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline-- --target--17139284 17016423 10592235
    Inhibitor of P38 Kinase-- --target--17139284 17016423 10592235
    N-[(3z)-5-Tert-Butyl-2-Phenyl-1,2-Dihydro-3h-Pyrazol-3-Ylidene]-N'-(4-Chlorophenyl)Urea-- --target--17139284 17016423 10592235
    SB220025-- --target--17139284 17016423 10592235
    1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One-- --target--17139284 17016423
    1-(5-Tert-Butyl-2-P-Tolyl-2h-Pyrazol-3-Yl)-3-[4-(2-Morpholin-4-Yl-Ethoxy)-Naphthalen-1-Yl]-Urea-- --target--17139284 17016423

    10/140 Novoseek inferred chemical compound relationships for MAPK14 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 97.5 706 10702313 (3), 11524243 (3), 19959817 (3), 16838116 (3) (see all 99)
    sp 600125 90 71 15964311 (2), 12697041 (1), 16440327 (1), 16433890 (1) (see all 64)
    pd 98,059 90 160 12663671 (2), 10794715 (2), 10601300 (1), 10082133 (1) (see all 99)
    pyridinylimidazole 87.2 38 9224565 (5), 14594946 (3), 9827991 (2), 10878289 (2) (see all 24)
    pd 169316 87 40 11141234 (3), 11811942 (2), 15572410 (2), 11500937 (2) (see all 30)
    anisomycin 81 65 18060783 (3), 16683917 (2), 15054109 (2), 8761479 (2) (see all 44)
    rwj 67657 75.5 1 12962514 (1)
    ly294002 73.7 39 17303382 (2), 12204874 (1), 12781867 (1), 15547762 (1) (see all 32)
    phosphatidylinositol 72.2 120 18036649 (3), 9605580 (2), 15082758 (2), 15024026 (2) (see all 99)
    wortmannin 71.3 27 9605580 (1), 18437163 (1), 19377829 (1), 11510895 (1) (see all 25)

    Search CenterWatch for drugs/clinical trials and news about MAPK14 / MK14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAPK14 gene (4 alternative transcripts): 
    NM_001315.2  NM_139012.2  NM_139013.2  NM_139014.2  

    Unigene Cluster for MAPK14:

    Mitogen-activated protein kinase 14
    Hs.485233  [show with all ESTs]
    Unigene Representative Sequence: NM_001315
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229795(uc003olp.3 uc003olq.3 uc003olr.3 uc011dti.2)
    ENST00000229794(uc003olo.3) ENST00000468133 ENST00000496250(uc011dth.2)
    ENST00000491957 ENST00000310795 ENST00000474429 ENST00000472333 ENST00000490379

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK14
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK14 (see all 46):
    hsa-miR-124* hsa-miR-3616-5p hsa-miR-128 hsa-miR-16-1* hsa-miR-3142 hsa-miR-124 hsa-miR-629* hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidMAPK14 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAPK14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK14
    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK14 (see all 29)
    OriGene ORF clones in mouse, rat for MAPK14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK14 (NM_139012)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK14
    Sirion Biotech Customized lentivirus for stable overexpression of MAPK14 
                         Customized lentivirus expression plasmids for stable overexpression of MAPK14 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAPK14
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPK14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK14

    Additional mRNA sequence: 

    AB074150.1 AF100544.1 AK291709.1 AK303414.1 BC000092.1 BC031574.1 BT006933.1 CR536505.1 
    FJ032367.1 FJ032368.1 L35263.1 L35264.1 Z25432.1 

    15 DOTS entries:

    DT.100843331  DT.118633  DT.91755525  DT.121316865  DT.100732109  DT.121316903  DT.121316935  DT.70101617 
    DT.428535  DT.100660365  DT.101962528  DT.91755514  DT.91755516  DT.100038032  DT.95252849 

    24/308 AceView cDNA sequences (see all 308):

    AI421691 BU622697 AI424478 L35263 CA436670 BM981077 AW151097 BX646706 
    BF154903 NM_139012 AA857845 AW503710 BU631727 AI862779 AW572148 AU186028 
    BM718552 BG251020 BQ226837 T31125 BM698138 AI902900 BM449484 CB155348 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK14 expression in normal human tissues (normalized intensities)      MAPK14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTGGCTG
    MAPK14 Expression
    About this image


    MAPK14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             neutrophils   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             stem cells (umbilical cord cd34+)   
     
     Liver (Hepatobiliary System)
             Hepatoblasts Liver Bud

    See MAPK14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK14

    SOURCE GeneReport for Unigene cluster: Hs.485233

    UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539
    Tissue specificity: Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung,
    liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK14 (see all 18): 
              Antiviral Response in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAPK14
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPK14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK14 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk141 , 5 mitogen-activated protein kinase 141, 5 90(n)1
    99.44(a)1
      17 (14.85 cM)5
    264161  NM_001168508.11  NP_001161980.11 
     286913425 
    chicken
    (Gallus gallus)
    Aves MAPK141 mitogen-activated protein kinase 14 82.04(n)
    92.5(a)
      421183  XM_001232615.1  XP_001232616.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK146
    Uncharacterized protein
    92(a)
    1 ↔ 1
    GL343382.1(640903-679471)
    African clawed frog
    (Xenopus laevis)
    Amphibia mapk14a-prov2 Mitogen-activated protein kinase 2 78.66(n)    BC056064.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB030897.12   -- 78.23(n)   65237  AB030897.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p38b1 , 3 regulation of BMP signaling pathway
    protein serine/threonine more3
    CG7393-PA1
    69(a)
    (best of 3)3
    64.19(n)1
    70(a)1
      34D13
    347801  NM_058013.41  NP_477361.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pmk-11 , 3 ser/thr kinases3
    Protein PMK-11
    65(a)
    (best of 6)3
    60.11(n)1
    64.04(a)1
      IV(8148976-8149980)3
    1917431  NM_068964.21  NP_501365.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HOG1(YLR113W)4
    HOG11
    Mitogen-activated protein kinase involved in osmoregulation; more4
    Hog1p1
    56.05(n)1
    53.57(a)1
      12(371620-372927)4
    8508031, 4  NP_013214.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MPK31 extracellular signal-regulated kinase 1/2 54(n)
    46.49(a)
      823706  NM_114433.2  NP_190150.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02858001 hypothetical protein 53.21(n)
    47.59(a)
      4332475  NM_001056305.1  NP_001049770.1 


    ENSEMBL Gene Tree for MAPK14 (if available)
    TreeFam Gene Tree for MAPK14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK14 gene
    MAPK92  MAPK122  MAPK132  MAPK112  MAPK82  MAPK102  
    18/104 SIMAP similar genes for MAPK14 using alignment to 7 protein entries:     MK14_HUMAN (see all proteins) (see all similar genes):
    MAPK11    MAPK13    MAPK12    DKFZp686M02159    MAPK8    MAPK9
    MAPK10    MAPK7    MAPK1    DKFZp686O0215    MAPK3    NLK
    MAPK4    CAMKK2    MAPK6    PRPF4B    AKT2    PRKACA

    MAPK14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1915 SNPs in MAPK14 are shown (see all 1915)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0422704
    A gastric adenocarcinoma sample4--see VAR_0422702 A V mis40--------
    VAR_0422714
    A lung adenocarcinoma sample4--see VAR_0422712 P R mis40--------
    rs597348841,2
    C--35972816(+) AAAAA-/A/AAA 
            
    CAACT
    4 -- int11NA 2
    rs617630901,2
    F--35994420(+) TTTTGTTTTTG/-
            
    AGACG
    4 -- us2k12Minor allele frequency- -:0.02NS 92
    rs1510393961,2
    C--35994430(+) GAGACA/GGAGTC 4 -- us2k10--------
    rs1409314361,2
    --35994499(+) CTCCTG/TGATTC 4 -- us2k10--------
    rs1881490181,2
    --35994564(+) CCACGC/TCCAGC 4 -- us2k10--------
    rs1916257581,2
    --35994841(+) TCTTTC/TTTTCT 4 -- us2k10--------
    rs1838683431,2
    --35994852(+) TTCTTC/TCTTTT 4 -- us2k10--------
    rs604815321,2
    C,F--35994942(+) TCAAGC/TGATTC 4 -- us2k14Minor allele frequency- T:0.09NS NA 126

    HapMap Linkage Disequilibrium report for MAPK14 (35995454 - 36079013 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MAPK14:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2399081CNV Deletion18987734
    esv2731916CNV Deletion23290073
    esv2731919CNV Deletion23290073
    esv269948CNV Insertion20981092
    nsv528432CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK14
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600289    OMIM disorders: --

    20/167 diseases for MAPK14 (see all 167):    About MalaCards
    doxorubicin induced cardiomyopathy    alexander disease    labyrinthitis    influenza
    fibrodysplasia ossificans progressiva    oral cavity cancer    pemphigus    avian influenza
    pemphigus foliaceus    gastric ulcer    antiphospholipid syndrome    keloids
    ureteral obstruction    clostridium difficile    japanese encephalitis    balanitis
    osteomyelitis    pemphigus vulgaris    cystitis    hellp syndrome

    4 diseases from the University of Copenhagen DISEASES database for MAPK14:
    Arthritis     Cancer     Vascular disease     Neurodegenerative disease

    MAPK14 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for MAPK14 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 74.1 152 10783388 (2), 15257094 (2), 16469115 (2), 18501892 (2) (see all 99)
    inflammation 68.4 72 9069290 (1), 12354421 (1), 12542980 (1), 16442754 (1) (see all 66)
    tumors 61 167 10783388 (2), 15257094 (2), 11165942 (2), 20413844 (2) (see all 99)
    shock 55.9 81 12077134 (4), 11710946 (2), 12614460 (2), 16955245 (2) (see all 65)
    rheumatoid arthritis 46.7 28 12833650 (3), 19180516 (2), 15778394 (1), 16702443 (1) (see all 21)
    atherosclerosis 45.3 9 18055523 (1), 18830681 (1), 15809308 (1), 15155098 (1) (see all 7)
    cancer 41.1 45 18060783 (3), 15102355 (2), 12790339 (2), 14598883 (1) (see all 37)
    colon cancer 40.3 10 19845689 (2), 18444174 (1), 16982754 (1), 16715142 (1) (see all 9)
    neurodegeneration 29.6 3 12528314 (1), 11060807 (1), 14552880 (1)
    pulmonary disease chronic obstructive 29.5 4 19880675 (1), 17959643 (1), 20093202 (1), 19004925 (1)

    Genetic Association Database (GAD): MAPK14
    Human Genome Epidemiology (HuGE) Navigator: MAPK14 (20 documents)

    Export disorders for MAPK14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK14 gene, integrated from 9 sources (see all 3265):
    (articles sorted by number of sources associating them with MAPK14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. (PubMed id 7997261)1, 2, 3 Lee J.C.... Young P.R. (1994)
    2. Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2. (PubMed id 10838079)1, 2, 9 Sanz V.... Crespo P. (2000)
    3. Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase. (PubMed id 16342939)1, 2, 9 Sullivan J.E....Ward W.H. (2005)
    4. Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4. (PubMed id 10727080)1, 2, 9 Herbison C.E.... Price P. (1999)
    5. Molecular cloning of human p38 MAP kinase. (PubMed id 7696354)1, 2, 9 Han J.... Ulevitch R.J. (1995)
    6. Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. (PubMed id 17255097)1, 2, 9 ter Haar E....Lepre C. (2007)
    7. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. (PubMed id 11847341)1, 2, 9 Ge B....Han J. (2002)
    8. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. (PubMed id 8622669)1, 2, 9 Raingeaud J.... Davis R.J. (1996)
    9. Direct activation of TACE-mediated ectodomain sheddin g by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. (PubMed id 20188673)1, 2, 9 Xu P. and Derynck R. (2010)
    10. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. (PubMed id 11896401)1, 2, 9 Pargellis C....Regan J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1432 HGNC: 6876 AceView: MAPK14 Ensembl:ENSG00000112062 euGenes: HUgn1432
    ECgene: MAPK14 Kegg: 1432 H-InvDB: MAPK14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK14 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/P38_mitogen-activated_protein_kinases

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAPK14 gene:
    Search GeneIP for patents involving MAPK14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for MAPK14
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK14
     EMD Millipore Kits and Assays for the Analysis of MAPK14
     EMD Millipore Purified and/or Recombinant MAPK14 Protein
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for MAPK14 (p38 alpha)   Browse Cell Culture Products  
     ELISAs for MAPK14 (p38 alpha)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for MAPK14 (p38 alpha)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for MAPK14 (p38 alpha)  
     OriGene Antibodies for MAPK14   OriGene RNAi products in human, mouse, rat for MAPK14  
     OriGene qPCR primer pairs and template standards for MAPK14   OriGene Protein Over-expression Lysate for MAPK14  
     OriGene MassSpec something-or-other for MAPK14   OriGene clones in human, mouse for MAPK14  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAPK14   OriGene Purified Protein for MAPK14  
     OriGene ORF clones in mouse, rat for MAPK14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAPK14   OriGene Custom Protein Services for MAPK14  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAPK14
     QIAGEN SeqTarget long-range PCR primers for resequencing MAPK14
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK14
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK14
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK14
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK14
     GenScript Custom Purified and Recombinant Proteins Services for MAPK14 GenScript cDNA clones with any tag delivered in your preferred vector for MAPK14
     GenScript Custom Assay Services for MAPK14 GenScript Custom Superior Antibodies Services for MAPK14
     GenScript Custom overexpressing Cell Line Services for MAPK14 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for MAPK14  (P38A)

     Regulatory tfbs in MAPK14 promoter
     Search Chromatin IP Primers for MAPK14
     RT2 qPCR Primer Assay in human, mouse, rat MAPK14
     GNC Network for MAPK14
     SABiosciences PCR Arrays including human, mouse, rat MAPK14
     Tocris compounds for MAPK14
     Proteins and Antibodies for MAPK14
     Cell Lysates for MAPK14
     cDNA Clones for MAPK14
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MAPK14 antibodies
     MAPK14 proteins
     MAPK14 lysates
     Antibodies for MAPK14
     See all of Abcam's Antibodies, Kits and Proteins for MAPK14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MAPK14
     Antibodies for MAPK14
     ELISAs for MAPK14
     CLIAs for MAPK14
     Search LifeMap BioReagents cell lines for MAPK14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK14
     SwitchGear 3'UTR luciferase reporter plasmids for MAPK14
     Browse SwitchGear Promoter luciferase reporter plasmids for MAPK14
     ThermoFisher Antibody for MAPK14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK14
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MAPK14
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAPK14
    Customized:
     lentivirus for stable overexpression of MAPK14
     lentivirus expression plasmids for stable overexpression of MAPK14
     adenovirus for overexpression of MAPK14
     LSBio Antibodies in human, mouse, rat for MAPK14
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAPK14 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4