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Aliases for MAPK14 Gene

Aliases for MAPK14 Gene

  • Mitogen-Activated Protein Kinase 14 2 3 5
  • Mitogen-Activated Protein Kinase P38 Alpha 3 4
  • MAX-Interacting Protein 2 3 4
  • CSAID-Binding Protein 3 4
  • MAP Kinase P38 Alpha 3 4
  • P38 MAP Kinase 2 3
  • MAP Kinase 14 3 4
  • EC 2.7.11.24 4 61
  • SAPK2A 3 4
  • CSBP1 3 4
  • CSBP2 3 4
  • CSPB1 3 4
  • CSBP 3 4
  • Mxi2 3 4
  • Cytokine Suppressive Anti-Inflammatory Drug Binding Protein 3
  • Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein 4
  • P38 Mitogen Activated Protein Kinase 3
  • Stress-Activated Protein Kinase 2A 3
  • Stress-Activated Protein Kinase 2a 4
  • Csaids Binding Protein 3
  • MAP Kinase Mxi2 3
  • MAP Kinase MXI2 4
  • P38alpha Exip 3
  • EC 2.7.11 61
  • P38ALPHA 3
  • MAPK 14 4
  • PRKM14 3
  • PRKM15 3
  • EXIP 3
  • P38 3
  • RK 3

External Ids for MAPK14 Gene

Previous HGNC Symbols for MAPK14 Gene

  • CSPB1
  • CSBP1
  • CSBP2

Previous GeneCards Identifiers for MAPK14 Gene

  • GC06P035997
  • GC06P036042
  • GC06P036103
  • GC06P035715
  • GC06P035995
  • GC06P036834
  • GC06P036915
  • GC06P037777
  • GC06P038401

Summaries for MAPK14 Gene

Entrez Gene Summary for MAPK14 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK14 Gene

MAPK14 (Mitogen-Activated Protein Kinase 14) is a Protein Coding gene. Diseases associated with MAPK14 include Tuberculosis and Patellar Tendinitis. Among its related pathways are Activated TLR4 signalling and Regulation of retinoblastoma protein. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK11.

UniProtKB/Swiss-Prot for MAPK14 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at Thr-113.

  • (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minute and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573).

Tocris Summary for MAPK14 Gene

  • MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions.

Gene Wiki entry for MAPK14 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK14 Gene

Genomics for MAPK14 Gene

Regulatory Elements for MAPK14 Gene

Enhancers for MAPK14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F036592 2.5 FANTOM5 ENCODE 9.9 +569.8 569784 10.7 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC KCTD20 ENSG00000237719 LAP3P2 CDKN1A RAB44 CMTR1 STK38 RNU1-88P RN7SL502P TBC1D22B
GH06F036439 1.6 FANTOM5 ENCODE 12.5 +415.2 415213 6.9 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ETV7 KCTD20 RPL10A MAPK14 ENSG00000237719 PXT1 LOC105375037 CDKN1A ENSG00000219023 PI16
GH06F036116 1.4 FANTOM5 ENCODE 13.8 +92.2 92181 6.4 HDGF PKNOX1 ARNT CREB3L1 SIN3A CBX5 FOS PAF1 ZNF263 JUNB SLC26A8 PXT1 SRPK1 MAPK14 BRPF3 MAPK13 LOC102723648 DEF6 STK38 TCP11
GH06F036063 1.3 Ensembl ENCODE 14.6 +38.7 38653 6.3 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B FEZF1 DMAP1 ZNF2 YY1 SLC26A8 MAPK14 ENSG00000272374 ENSG00000237719 MAPK13 ENSG00000219023 FANCE RPL10A TCP11
GH06F036098 1.2 Ensembl ENCODE 14.3 +73.1 73087 4.8 HDGF ATF1 PKNOX1 ARNT GATA2 JUNB REST ZNF623 MEF2D MBD2 SLC26A8 MAPK13 MAPK14 ENSG00000272374 ENSG00000237719 BRPF3 LOC102723648 ENSG00000219023 FANCE SRPK1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAPK14 on UCSC Golden Path with GeneCards custom track

Promoters for MAPK14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001494846 1265 3401 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for MAPK14 Gene

Chromosome:
6
Start:
36,027,635 bp from pter
End:
36,111,236 bp from pter
Size:
83,602 bases
Orientation:
Plus strand

Genomic View for MAPK14 Gene

Genes around MAPK14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK14 Gene

Proteins for MAPK14 Gene

  • Protein details for MAPK14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16539-MK14_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 14
    Protein Accession:
    Q16539
    Secondary Accessions:
    • A6ZJ92
    • A8K6P4
    • B0LPH0
    • B5TY32
    • O60776
    • Q13083
    • Q14084
    • Q8TDX0

    Protein attributes for MAPK14 Gene

    Size:
    360 amino acids
    Molecular mass:
    41293 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with SPAG9 and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1. Interacts with casein kinase II subunits CSNK2A1 and CSNK2B. Interacts with PPM1D. Interacts with CDK5RAP3; recruits PPM1D to MAPK14 and may regulate its dephosphorylation (PubMed:21283629).

    Three dimensional structures from OCA and Proteopedia for MAPK14 Gene

    Alternative splice isoforms for MAPK14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK14 Gene

Selected DME Specific Peptides for MAPK14 Gene

Q16539:
  • YVATRWYR
  • QTVDIWSVGCIMAE
  • LFPGTDHI
  • AHAYFAQ
  • GLKYIHSA
  • AKRTYRE
  • YHDPDDEP
  • ILDFGLA
  • YRELRLLKHM
  • EEFNDVY
  • KKLSRPFQ
  • VFIGANP
  • ISSESARNYI
  • YQILRGLKY
  • NKTIWEVP
  • LKYIHSA
  • DTKTGLR
  • AVNEDCEL
  • YRAPEIML
  • LMGADLNNIVKCQ
  • FVPPPLD
  • DDHVQFL
  • DIWSVGCI
  • LDFGLAR
  • HENVIGLLD
  • VYLVTHLM
  • DLLEKML
  • LLDVFTP
  • VGSGAYG
  • TRWYRAPE
  • FYRQELNKT
  • LKILDFGLAR
  • RPFQSIIHA
  • ADPYDQSFESRDL

Post-translational modifications for MAPK14 Gene

  • Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and enhances kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC3.
  • Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to inflammatory citokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation can also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323 phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP16. PPM1D also mediates dephosphorylation and inactivation of MAPK14 (PubMed:21283629).
  • Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway.
  • Ubiquitination at Lys 15, Lys 45, Lys 139, Lys 152, Lys 165, and Lys 233
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPK14 (P38A)
  • Cloud-Clone Corp. Antibodies for MAPK14

Domains & Families for MAPK14 Gene

Graphical View of Domain Structure for InterPro Entry

Q16539

UniProtKB/Swiss-Prot:

MK14_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK14: view

Function for MAPK14 Gene

Molecular function for MAPK14 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase14
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by cell stresses such as DNA damage, heat shock, osmotic shock, anisomycin and sodium arsenite, as well as pro-inflammatory stimuli such as bacterial lipopolysaccharide (LPS) and interleukin-1. Activation occurs through dual phosphorylation of Thr-180 and Tyr-182 by either of two dual specificity kinases, MAP2K3/MKK3 or MAP2K6/MKK6, and potentially also MAP2K4/MKK4, as well as by TAB1-mediated autophosphorylation. MAPK14 phosphorylated on both Thr-180 and Tyr-182 is 10-20-fold more active than MAPK14 phosphorylated only on Thr-180, whereas MAPK14 phosphorylated on Tyr-182 alone is inactive. whereas Thr-180 is necessary for catalysis, Tyr-182 may be required for auto-activation and substrate recognition. Phosphorylated at Tyr-323 by ZAP70 in an alternative activation pathway in response to TCR signaling in T-cells. This alternative pathway is inhibited by GADD45A. Inhibited by dual specificity phosphatases, such as DUSP1, DUSP10, and DUSP16. Specifically inhibited by the binding of pyridinyl-imidazole compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID). Isoform Mxi2 is 100-fold less sensitive to these agents than the other isoforms and is not inhibited by DUSP1. Isoform Exip is not activated by MAP2K6. SB203580 is an inhibitor of MAPK14.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at Thr-113.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minute and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573).

Enzyme Numbers (IUBMB) for MAPK14 Gene

Gene Ontology (GO) - Molecular Function for MAPK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0004707 MAP kinase activity IEA,IDA 7997261
GO:0004708 MAP kinase kinase activity TAS 10706854
genes like me logo Genes that share ontologies with MAPK14: view
genes like me logo Genes that share phenotypes with MAPK14: view

Animal Models for MAPK14 Gene

MGI Knock Outs for MAPK14:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAPK14

miRNA for MAPK14 Gene

miRTarBase miRNAs that target MAPK14

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK14 Gene

Localization for MAPK14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK14 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK14 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 3
plasma membrane 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MAPK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005622 intracellular IEA --
GO:0005623 cell IEA --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with MAPK14: view

Pathways & Interactions for MAPK14 Gene

SuperPathways for MAPK14 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 IL-2 Pathway
3 Toll-Like receptor Signaling Pathways
4 4-1BB Pathway
5 RET signaling
genes like me logo Genes that share pathways with MAPK14: view

Pathways by source for MAPK14 Gene

Gene Ontology (GO) - Biological Process for MAPK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IEA --
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0000902 cell morphogenesis IEA --
GO:0001502 cartilage condensation IEA --
genes like me logo Genes that share ontologies with MAPK14: view

Drugs & Compounds for MAPK14 Gene

(161) Drugs for MAPK14 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
SB220025 Experimental Pharma Target 0
[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE Experimental Pharma Target 0
[5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE Experimental Pharma Target 0
1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One Experimental Pharma Target 0

(72) Additional Compounds for MAPK14 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
PH 797804
1358027-80-1
SB 202190
152121-30-7

(5) Tocris Compounds for MAPK14 Gene

Compound Action Cas Number
BIRB 796 High affinity and selective p38 kinase inhibitor 285983-48-4
PH 797804 Potent and selective p38alpha/beta inhibitor 1358027-80-1
SB 202190 Potent, selective inhibitor of p38 MAPK 152121-30-7
SB 203580 Selective inhibitor of p38 MAPK 152121-47-6
SB 203580 hydrochloride Selective inhibitor of p38 MAPK; water-soluble 869185-85-3

(27) ApexBio Compounds for MAPK14 Gene

Compound Action Cas Number
AL 8697 p38α inhibitor,potent and selective 1057394-06-5
AMG 548 P38α inhibitor,potent and selective 864249-60-5
Asiatic acid Used in wound healing;anti-inflammatory 464-92-6
BIRB 796 (Doramapimod) P38 MAPK inhibitor,cell permeable and highly selective 285983-48-4
CMPD-1 41179-33-3
DBM 1285 dihydrochloride
EO 1428 321351-00-2
JX 401 349087-34-9
Losmapimod 585543-15-3
LY2228820 P38 MAP kinase inhibitor 862507-23-1
PD 169316 P38 MAPK inhibitor 152121-53-4
Pexmetinib (ARRY-614) dual inhibitor of p38 MAPK and Tie2/Tek receptor tyrosine kinase 945614-12-0
PH-797804 P38 MAP kinase inhibitor, potent and selective 586379-66-0
Piperine MAPK inhibitor 94-62-2
SB 203580 P38 MAP kinase inhibitor 152121-47-6
SB 203580 hydrochloride Specific p38-MAPKs inhibitor 869185-85-3
SB 239063 P38 MAP kinase inhibitor 193551-21-2
SB 242235 MAPK inhibitor 193746-75-7
SB 706504 911110-38-8
SB202190 (FHPI) P38 MAPK inhibitor 152121-30-7
SD-06 271576-80-8
Skepinone-L P38-MAPK inhibitor,potent and selective 1221485-83-1
SKF 86002 dihydrochloride 116339-68-5
SX 011 309913-42-6
TAK-715 p38 MAPK inhibitor 303162-79-0
VX-702 P38α MAPK inhibitor,highly selective and ATP-competitive 479543-46-9
VX-745 P38α inhibitor,highly potent and selective 209410-46-8
genes like me logo Genes that share compounds with MAPK14: view

Drug Products

Transcripts for MAPK14 Gene

Unigene Clusters for MAPK14 Gene

Mitogen-activated protein kinase 14:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK14 Gene

No ASD Table

Relevant External Links for MAPK14 Gene

GeneLoc Exon Structure for
MAPK14
ECgene alternative splicing isoforms for
MAPK14

Expression for MAPK14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK14 Gene

This gene is overexpressed in Whole Blood (x9.8).

Protein differential expression in normal tissues from HIPED for MAPK14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.6) and Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPK14 Gene



Protein tissue co-expression partners for MAPK14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAPK14 Gene:

MAPK14

SOURCE GeneReport for Unigene cluster for MAPK14 Gene:

Hs.485233

mRNA Expression by UniProt/SwissProt for MAPK14 Gene:

Q16539-MK14_HUMAN
Tissue specificity: Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.
genes like me logo Genes that share expression patterns with MAPK14: view

Orthologs for MAPK14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK14 34 35
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia MAPK14 34 35
  • 95.28 (n)
oppossum
(Monodelphis domestica)
Mammalia MAPK14 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK14 34 35
  • 92.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK14 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk14 34 16 35
  • 90 (n)
rat
(Rattus norvegicus)
Mammalia Mapk14 34
  • 90 (n)
chicken
(Gallus gallus)
Aves MAPK14 34 35
  • 82.04 (n)
lizard
(Anolis carolinensis)
Reptilia MAPK14 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk14 34
  • 75.67 (n)
Str.15151 34
African clawed frog
(Xenopus laevis)
Amphibia mapk14a-prov 34
zebrafish
(Danio rerio)
Actinopterygii mapk14b 35
  • 92 (a)
OneToMany
mapk14a 34 35
  • 77.69 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Mpk2 36 35
  • 68 (a)
p38b 36 34 35
  • 64.19 (n)
p38c 36 35
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012148 34
  • 63.95 (n)
worm
(Caenorhabditis elegans)
Secernentea pmk-1 36 34 35
  • 60.11 (n)
pmk-2 35
  • 48 (a)
ManyToMany
pmk-3 36
  • 43 (a)
F09C12.2 36
  • 41 (a)
C49C3.10b 36
  • 34 (a)
Y51B9A.9 36
  • 34 (a)
C49C3.10a 36
  • 32 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR048C 34
  • 56.18 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOG1 34 35 37
  • 56.15 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20053g 34
  • 53.57 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MPK3 34
  • 54 (n)
rice
(Oryza sativa)
Liliopsida Os03g0285800 34
  • 53.21 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 68 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sty1 34
  • 55.85 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07024 34
  • 54.86 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6890 34
Species where no ortholog for MAPK14 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK14 Gene

ENSEMBL:
Gene Tree for MAPK14 (if available)
TreeFam:
Gene Tree for MAPK14 (if available)

Paralogs for MAPK14 Gene

Paralogs for MAPK14 Gene

genes like me logo Genes that share paralogs with MAPK14: view

Variants for MAPK14 Gene

Sequence variations from dbSNP and Humsavar for MAPK14 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_042270 A gastric adenocarcinoma sample
VAR_042271 A lung adenocarcinoma sample
rs1050576 -- 36,096,013(+) TTTTA(A/C)GACTC intron-variant, nc-transcript-variant, reference, synonymous-codon
rs1050577 -- 36,096,015(+) TTAAG(A/T)CTCGT intron-variant, nc-transcript-variant, reference, missense
rs1050578 -- 36,096,031(+) CCCCA(C/G)GGGCT intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAPK14 Gene

Variant ID Type Subtype PubMed ID
esv2399081 CNV deletion 18987734
esv2731916 CNV deletion 23290073
esv2731919 CNV deletion 23290073
esv3305671 CNV mobile element insertion 20981092
esv3430637 CNV insertion 20981092
esv3437491 CNV insertion 20981092
nsv528432 CNV gain 19592680
nsv950162 CNV duplication 24416366

Variation tolerance for MAPK14 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK14 Gene

Disorders for MAPK14 Gene

MalaCards: The human disease database

(15) MalaCards diseases for MAPK14 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tuberculosis