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MAPK14 Gene

protein-coding   GIFtS: 76
GCID: GC06P035995

Mitogen-Activated Protein Kinase 14


(Previous symbols: CSPB1, CSBP1, CSBP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 141 2     EXIP2
CSBP11 2 3 5     Mxi22
CSBP21 2 3     PRKM142
CSPB11 2 3     PRKM152
P38 MAP Kinase1 2     RK2
Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein2 3     Csaids Binding Protein2
MAP Kinase MXI22 3     Cytokine Suppressive Anti-Inflammatory Drug Binding Protein2
Mitogen-Activated Protein Kinase P38 Alpha2 3     p382
Stress-Activated Protein Kinase 2a2 3     P38 Mitogen Activated Protein Kinase2
CSBP2 3     p38ALPHA2
SAPK2A2 3     P38alpha Exip2
CSAID-Binding Protein2 3     MXI23
MAP Kinase 142 3     SAPK2a3
MAP Kinase P38 Alpha2 3     MAPK 143
MAX-Interacting Protein 22 3     EC 2.7.118
EC 2.7.11.243 8     

External Ids:    HGNC: 68761   Entrez Gene: 14322   Ensembl: ENSG000001120627   OMIM: 6002895   UniProtKB: Q165393   

Export aliases for MAPK14 gene to outside databases

Previous GC identifers: GC06P035997 GC06P036042 GC06P036103 GC06P035715


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK14 Gene:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. This kinase is activated by various environmental
stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs),
or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The
substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and
tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle
regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene
encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPK14 Gene:
MAPK14 (mitogen-activated protein kinase 14) is a protein-coding gene. Diseases associated with MAPK14 include doxorubicin induced cardiomyopathy, and alexander disease. GO annotations related to this gene include MAP kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is MAPK9.

UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been
estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases
which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and
RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B
isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1.
RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to
stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription
machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control
of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and
ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and
MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the
initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through
autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an
important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose
proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates
the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal
degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein
ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms
that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by
inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of
RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to
inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such
phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in
the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be
translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes
such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many
transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical
examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging
as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of
several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent
enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This
phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for
increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3
proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA
damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have
kinase-independent roles, which are thought to be due to the binding to targets in the absence of
phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does
not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose
deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as
neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of
embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in
developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2
activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform
EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'

summary for MAPK14 Gene:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK14 gene promoter:
         MEF-2A   AP-1   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MAPK14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3-p21.2   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.3-p21.2

MAPK14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK14 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P035995:  view genomic region     (about GC identifiers)

Start:
35,995,454 bp from pter      End:
36,079,013 bp from pter
Size:
83,560 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 14  
Size: 360 amino acids; 41293 Da
Cofactor: Magnesium
Subunit: Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This
interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with
SPAG9 and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1.
Interacts with casein kinase II subunits CSNK2A1 and CSNK2B
Selected PDB 3D structures from and Proteopedia for MAPK14 (see all 201):
1A9U (3D)        1BL6 (3D)        1BL7 (3D)        1BMK (3D)        1DI9 (3D)        1IAN (3D)    
Secondary accessions: A6ZJ92 A8K6P4 B0LPH0 O60776 Q13083 Q14084 Q8TDX0
Alternative splicing: 4 isoforms:  Q16539-1   Q16539-2   Q16539-3   Q16539-4   

Explore the universe of human proteins at neXtProt for MAPK14: NX_Q16539

Explore proteomics data for MAPK14 at MOPED

Post-translational modifications: 

  • Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to
    inflammatory citokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation
    can also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323
    phosphorylation by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP161
  • Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and
    enhances kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC31
  • Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway1
  • Ubiquitination2 at Lys15, Lys45, Lys139, Lys152, Lys165, Lys233
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPK14 (Q16539) (see all 34)
     LKYIHSA  DTKTGLR  AHAYFAQ  FVPPPLD 


    See MAPK14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001306.1  NP_620581.1  NP_620582.1  NP_620583.1  

    ENSEMBL proteins: 
     ENSP00000229795   ENSP00000229794   ENSP00000419837   ENSP00000417531   ENSP00000308669  
     ENSP00000417065   ENSP00000419141  
    Reactome Protein details: Q16539

    MAPK14 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAPK14 Protein
    R&D Systems Recombinant & Natural Proteins for MAPK14 (p38 alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MAPK14
    OriGene Protein Over-expression Lysate for MAPK14
    OriGene MassSpec for MAPK14
    OriGene Custom Protein Services for MAPK14
    GenScript Custom Purified and Recombinant Proteins Services for MAPK14
    Novus Biologicals MAPK14 Proteins
    Novus Biologicals MAPK14 Lysates
    Sino Biological Recombinant Protein for MAPK14
    Sino Biological Cell Lysate for MAPK14
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAPK14

    MAPK14 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK14
    R&D Systems Antibodies for MAPK14 (p38 alpha)
    Cell Signaling Technology (CST) Antibodies for MAPK14  (P38A)
    OriGene Antibodies for MAPK14
    OriGene Custom Antibody Services for MAPK14
    Novus Biologicals MAPK14 Antibodies
    Abcam antibodies for MAPK14
    Cloud-Clone Corp. Antibodies for MAPK14
    ThermoFisher Antibody for MAPK14
    LSBio Antibodies in human, mouse, rat for MAPK14

    MAPK14 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of MAPK14
    OriGene Custom Assay Services for MAPK14
    R&D Systems ELISAs for MAPK14 (p38 alpha)         (see all)
    GenScript Custom Assay Services for MAPK14
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK14 (P38A)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK14
    Cloud-Clone Corp. CLIAs for MAPK14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 14
    p38 subfamily
    Mitogen-activated protein kinases

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q16539

    ProtoNet protein and cluster: Q16539

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK14_HUMAN, Q16539
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
    evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
    of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been
    estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases
    which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and
    RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B
    isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1.
    RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to
    stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription
    machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control
    of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and
    ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and
    MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the
    initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through
    autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an
    important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose
    proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates
    the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal
    degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein
    ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms
    that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by
    inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of
    RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to
    inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such
    phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in
    the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be
    translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes
    such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many
    transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical
    examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging
    as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of
    several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent
    enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This
    phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for
    increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3
    proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA
    damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have
    kinase-independent roles, which are thought to be due to the binding to targets in the absence of
    phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does
    not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose
    deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as
    neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of
    embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in
    developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2
    activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform
    EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by cell stresses such as DNA damage, heat shock, osmotic shock, anisomycin and sodium
    arsenite, as well as pro-inflammatory stimuli such as bacterial lipopolysaccharide (LPS) and interleukin-1.
    Activation occurs through dual phosphorylation of Thr-180 and Tyr-182 by either of two dual specificity kinases,
    MAP2K3/MKK3 or MAP2K6/MKK6, and potentially also MAP2K4/MKK4, as well as by TAB1-mediated autophosphorylation.
    MAPK14 phosphorylated on both Thr-180 and Tyr-182 is 10-20-fold more active than MAPK14 phosphorylated only on
    Thr-180, whereas MAPK14 phosphorylated on Tyr-182 alone is inactive. whereas Thr-180 is necessary for catalysis,
    Tyr-182 may be required for auto-activation and substrate recognition. Phosphorylated at Tyr-323 by ZAP70 in an
    alternative activation pathway in response to TCR signaling in T-cells. This alternative pathway is inhibited by
    GADD45A. Inhibited by dual specificity phosphatases, such as DUSP1, DUSP10, and DUSP16. Specifically inhibited by
    the binding of pyridinyl-imidazole compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID).
    Isoform Mxi2 is 100-fold less sensitive to these agents than the other isoforms and is not inhibited by DUSP1.
    Isoform Exip is not activated by MAP2K6. SB203580 is an inhibitor of MAPK14

         Genatlas biochemistry entry for MAPK14:
    mitogen-activated protein kinase14

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004707MAP kinase activity IDA10330143
    GO:0004708MAP kinase kinase activity TAS10706854
    GO:0004713protein tyrosine kinase activity ----
         
    MAPK14 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAPK14:
     Decreased number of cells in m  Decreased substrate adherent c  Decreased telomerase activity  Decreased viability after Chla 
     High actin ratio cells 

         Selected MGI mutant phenotypes (inferred from 13 alleles(MGI details for Mapk14) (see all 19):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  nervous system  normal 

    MAPK14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAPK14: Mapk14tm1Mms Mapk14tm1Gab Mapk14tm1Mka Mapk14tm1.1Otsu Mapk14tm1.1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPK14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK14

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPK14:
    hsa-mir-125b-5p (MIRT007066), hsa-mir-141-3p (MIRT006424), hsa-mir-124-3p (MIRT002610), hsa-mir-200a-3p (MIRT006423), hsa-mir-24-3p (MIRT002950)

    Block miRNA regulation of human, mouse, rat MAPK14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK14 (see all 46):
    hsa-miR-124* hsa-miR-3616-5p hsa-miR-128 hsa-miR-16-1* hsa-miR-3142 hsa-miR-124 hsa-miR-629* hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidMAPK14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPK14
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK14

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK14 (see all 28)
    OriGene ORF clones in mouse, rat for MAPK14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK14 (NM_139012)
    Sino Biological Human cDNA Clone for MAPK14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK14

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAPK14
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    MK14_HUMAN, Q16539: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular2
    mitochondrion2
    plasma membrane2
    golgi apparatus1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005623cell ----
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ISS--

    MAPK14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for MAPK14 About   (see all 169)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    2G protein signaling Ras family GTPases in kinase cascades scheme
    G protein signaling Ras family GTPases in kinase cascades scheme 0.44
    Oncostatin M Signaling Pathway0.37
    MAPK Cascade0.44
    Activation of the AP-1 family of transcription factors0.00
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    3Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Fc epsilon RI signaling pathway0.41
    VEGF - VEGF R2 Signaling Pathways0.35
    4B cell receptor signaling pathway (KEGG)
    BCR signaling pathway0.42
    TCR Signaling Pathway0.36
    T cell receptor signaling pathway0.38
    5MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP Kinase Signaling0.31
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    activated TAK1 mediates p38 MAPK activation0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for MAPK14 (see all 8)
        Inflammasome Activation Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK14 (see all 94)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK14
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK14
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MAPK14 (see all 32)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    Development Endothelin-1/EDNRA signaling
    Immune response IL-12-induced IFN-gamma production

    Selected BioSystems Pathways for MAPK14 (see all 68)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Senescence and Autophagy
    EGFR1 Signaling Pathway
    Insulin Signaling

    5 Sino Biological Pathways for MAPK14
        TNF Signaling
    Non-Canonical Wnt Pathway
    p53 Pathway
    VEGF Signaling
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for MAPK14 (see all 12)
        Activation of PPARGC1A (PGC-1alpha) by phosphorylation
    KSRP destabilizes mRNA
    DSCAM interactions
    activated TAK1 mediates p38 MAPK activation
    Oxidative Stress Induced Senescence

    2 PharmGKB Pathways for MAPK14
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for MAPK14) (see all 33):
        MAPK signaling pathway
    Rap1 signaling pathway
    FoxO signaling pathway
    Adrenergic signaling in cardiomyocytes
    VEGF signaling pathway


    MAPK14 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK14 (see all 18): 
              Antiviral Response in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK14 (Q165391, 2, 3 ENSP000002297944) via UniProtKB, MINT, STRING, and/or I2D (see all 619)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273611, 2, 3, ENSP000002630254EBI-73946,EBI-73995 MINT-8092346 MINT-8092357 MINT-8092337 I2D: score=5 STRING: ENSP00000263025
    DUSP9Q999561, 2, 3, ENSP000003458534EBI-73946,EBI-3906678 MINT-8287227 MINT-8287259 MINT-8287212 I2D: score=2 STRING: ENSP00000345853
    DUSP1P285621, 2, 3, ENSP000002392234EBI-73946,EBI-975493 MINT-8288609 MINT-8287194 I2D: score=7 STRING: ENSP00000239223
    ZFP36L1Q073521, 2, 3, ENSP000003373864EBI-73946,EBI-721823 MINT-66629 I2D: score=6 STRING: ENSP00000337386
    TAB1Q157502, 3, ENSP000002161604MINT-17883 MINT-8260174 MINT-17884 I2D: score=5 STRING: ENSP00000216160
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 69):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IEA--
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity TAS--
    GO:0000902cell morphogenesis IEA--
    GO:0001502cartilage condensation IEA--

    MAPK14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    10 ApexBio Compounds for MAPK14     About this table
    CompoundAction CAS #
    BIRB 796 (Doramapimod)Cell pemeable p38 MAP Kinase Inhibitor [285983-48-4]
    LY2228820Potent and ATP-competitive p38 MAP kinase inhibitor[862507-23-1]
    PD 169316p38 MAPK inhibitor[152121-53-4]
    PH-797804Potent and selective p38 MAP kinase inhibitor[586379-66-0]
    SB 203580Cell permeable, reversible, and ATP-competitive p38 MAP kinase inhibitor[152121-47-6]
    SB202190 (FHPI)highly selective, potent and cell-permeable inhibitor of p38 MAP kinase[152121-30-7]
    Skepinone-Lselective p38 mitogen-activated protein kinase inhibitor[1221485-83-1]
    TAK-715inhibitor of p38 MAPK[303162-79-0]
    VX-702P38 MAPK inhibitor[479543-46-9]
    VX-745highly potent and selective p38alpha inhibitor[209410-46-8]

    Compounds for MAPK14 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 239063 Potent, selective p38 MAPK inhibitor; orally active [193551-21-2]
    SB 202190 Potent, selective inhibitor of p38 MAPK [152121-30-7]
    SB 203580 hydrochlorideSelective inhibitor of p38 MAPK; water-soluble[152121-47-6]
    SB 203580Selective inhibitor of p38 MAPK[152121-47-6]
    SCIO 469 hydrochlorideSelective p38 MAPK inhibitor[309913-83-5]

    3 HMDB Compounds for MAPK14    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Selected DrugBank Compounds for MAPK14 (see all 50)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One-- --target--17139284 17016423 10592235
    1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea-- --target--17139284 17016423 10592235
    3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine-- --target--17139284 17016423 10592235
    3-(Benzyloxy)Pyridin-2-Amine-- --target--17139284 17016423 10592235
    4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline-- --target--17139284 17016423 10592235
    Inhibitor of P38 Kinase-- --target--17139284 17016423 10592235
    N-[(3z)-5-Tert-Butyl-2-Phenyl-1,2-Dihydro-3h-Pyrazol-3-Ylidene]-N'-(4-Chlorophenyl)Urea-- --target--17139284 17016423 10592235
    SB220025-- --target--17139284 17016423 10592235
    1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One-- --target--17139284 17016423
    1-(5-Tert-Butyl-2-P-Tolyl-2h-Pyrazol-3-Yl)-3-[4-(2-Morpholin-4-Yl-Ethoxy)-Naphthalen-1-Yl]-Urea-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for MAPK14 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 97.5 706 10702313 (3), 11524243 (3), 19959817 (3), 16838116 (3) (see all 99)
    sp 600125 90 71 15964311 (2), 12697041 (1), 16440327 (1), 16433890 (1) (see all 64)
    pd 98,059 90 160 12663671 (2), 10794715 (2), 10601300 (1), 10082133 (1) (see all 99)
    pyridinylimidazole 87.2 38 9224565 (5), 14594946 (3), 9827991 (2), 10878289 (2) (see all 24)
    pd 169316 87 40 11141234 (3), 11811942 (2), 15572410 (2), 11500937 (2) (see all 30)
    anisomycin 81 65 18060783 (3), 16683917 (2), 15054109 (2), 8761479 (2) (see all 44)
    rwj 67657 75.5 1 12962514 (1)
    ly294002 73.7 39 17303382 (2), 12204874 (1), 12781867 (1), 15547762 (1) (see all 32)
    phosphatidylinositol 72.2 120 18036649 (3), 9605580 (2), 15082758 (2), 15024026 (2) (see all 99)
    wortmannin 71.3 27 9605580 (1), 18437163 (1), 19377829 (1), 11510895 (1) (see all 25)



    MAPK14 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for MAPK14 gene (4 alternative transcripts): 
    NM_001315.2  NM_139012.2  NM_139013.2  NM_139014.2  

    Unigene Cluster for MAPK14:

    Mitogen-activated protein kinase 14
    Hs.485233  [show with all ESTs]
    Unigene Representative Sequence: NM_001315
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229795(uc003olp.3 uc003olq.3 uc003olr.3 uc011dti.2)
    ENST00000229794(uc003olo.3) ENST00000468133 ENST00000496250(uc011dth.2)
    ENST00000491957 ENST00000310795 ENST00000474429 ENST00000472333 ENST00000490379

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAPK14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK14 (see all 46):
    hsa-miR-124* hsa-miR-3616-5p hsa-miR-128 hsa-miR-16-1* hsa-miR-3142 hsa-miR-124 hsa-miR-629* hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidMAPK14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAPK14
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK14
    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK14 (see all 28)
    OriGene ORF clones in mouse, rat for MAPK14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK14 (NM_139012)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK14
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAPK14
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK14
      QuantiTect SYBR Green Assays in human, mouse, rat MAPK14
      QuantiFast Probe-based Assays in human, mouse, rat MAPK14

    Additional mRNA sequence: 

    AB074150.1 AF100544.1 AK291709.1 AK303414.1 BC000092.1 BC031574.1 BT006933.1 CR536505.1 
    FJ032367.1 FJ032368.1 L35263.1 L35264.1 Z25432.1 

    15 DOTS entries:

    DT.100843331  DT.118633  DT.91755525  DT.121316865  DT.100732109  DT.121316903  DT.121316935  DT.70101617 
    DT.428535  DT.100660365  DT.101962528  DT.91755514  DT.91755516  DT.100038032  DT.95252849 

    Selected AceView cDNA sequences (see all 308):

    BF154903 AW151097 AA993775 AI572278 Z45649 W92696 BQ773229 AA705107 
    BQ015964 AI424478 BM849403 L35264 AU186028 W88610 CB155348 AI192412 
    CA441540 CA436670 BM698138 AA041351 AF034185 BM449484 AA948637 BU180674 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAPK14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTGGCTG
    MAPK14 Expression
    About this image


    MAPK14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    MAPK14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485233

    UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539
    Tissue specificity: Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung,
    liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK14 (see all 18): 
              Antiviral Response in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAPK14
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK14
    QuantiTect SYBR Green Assays in human, mouse, rat MAPK14
    QuantiFast Probe-based Assays in human, mouse, rat MAPK14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK14 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk141 , 5 mitogen-activated protein kinase 141, 5 90(n)1
    99.44(a)1
      17 (14.85 cM)5
    264161  NM_001168508.11  NP_001161980.11 
     286913425 
    chicken
    (Gallus gallus)
    Aves MAPK141 mitogen-activated protein kinase 14 82.04(n)
    92.5(a)
      421183  XM_001232615.2  XP_001232616.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK146
    mitogen-activated protein kinase 14
    92(a)
    1 ↔ 1
    GL343382.1(640903-679471)
    African clawed frog
    (Xenopus laevis)
    Amphibia mapk14a-prov2 Mitogen-activated protein kinase 2 78.66(n)    BC056064.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB030897.12   -- 78.23(n)   65237  AB030897.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p38b1 , 3 regulation of BMP signaling pathway
    protein serine/threonine more3
    p38b1
    69(a)
    (best of 3)3
    64.19(n)1
    70(a)1
      34D13
    347801  NM_058013.41  NP_477361.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pmk-11 , 3 ser/thr kinases3
    pmk-11
    65(a)
    (best of 6)3
    60.11(n)1
    64.04(a)1
      IV(8148976-8149980)3
    1917431  NM_068964.31  NP_501365.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HOG1(YLR113W)4
    HOG11
    Mitogen-activated protein kinase involved in osmoregulation; more4
    HOG11
    56.15(n)1
    53.57(a)1
      12(371620-372927)4
    8508031, 4  NP_013214.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MPK31 MPK3 54(n)
    46.49(a)
      823706  NM_114433.2  NP_190150.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02858001 Os03g0285800 53.21(n)
    47.59(a)
      4332475  NM_001056305.1  NP_001049770.1 


    ENSEMBL Gene Tree for MAPK14 (if available)
    TreeFam Gene Tree for MAPK14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for MAPK14 gene
    MAPK92  MAPK122  MAPK132  MAPK112  MAPK82  MAPK102  
    Selected SIMAP similar genes for MAPK14 using alignment to 7 protein entries:     MK14_HUMAN (see all proteins) (see all similar genes):
    MAPK11    MAPK13    MAPK12    DKFZp686M02159    MAPK8    MAPK9
    MAPK10    MAPK1    MAPK7    DKFZp686O0215    MAPK3    NLK
    MAPK4    CAMKK2    MAPK6    PRPF4B    AKT2    PRKACA

    MAPK14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MAPK14 (see all 1915)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0422704
    A gastric adenocarcinoma sample4--see VAR_0422702 A V mis40--------
    VAR_0422714
    A lung adenocarcinoma sample4--see VAR_0422712 P R mis40--------
    rs597348841,2
    C--35972816(+) AAAAA-/A/AAA 
            
    CAACT
    4 -- int11NA 2
    rs617630901,2
    F--35994420(+) TTTTGTTTTTG/-
            
    AGACG
    4 -- us2k12Minor allele frequency- -:0.02NS 92
    rs1510393961,2
    C--35994430(+) GAGACA/GGAGTC 4 -- us2k10--------
    rs1409314361,2
    --35994499(+) CTCCTG/TGATTC 4 -- us2k10--------
    rs1881490181,2
    --35994564(+) CCACGC/TCCAGC 4 -- us2k10--------
    rs1916257581,2
    --35994841(+) TCTTTC/TTTTCT 4 -- us2k10--------
    rs1838683431,2
    --35994852(+) TTCTTC/TCTTTT 4 -- us2k10--------
    rs604815321,2
    C,F--35994942(+) TCAAGC/TGATTC 4 -- us2k14Minor allele frequency- T:0.09NS NA 126

    HapMap Linkage Disequilibrium report for MAPK14 (35995454 - 36079013 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MAPK14:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2399081CNV Deletion18987734
    esv2731916CNV Deletion23290073
    esv2731919CNV Deletion23290073
    esv269948CNV Insertion20981092
    nsv528432CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK14
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600289    OMIM disorders: --

    Selected diseases for MAPK14 (see all 174):    
    About MalaCards
    doxorubicin induced cardiomyopathy    alexander disease    labyrinthitis    fibrodysplasia ossificans progressiva
    influenza    oral cavity cancer    pemphigus foliaceus    gastric ulcer
    avian influenza    antiphospholipid syndrome    keloids    pemphigus
    ureteral obstruction    balanitis    japanese encephalitis    osteomyelitis
    sarcoidosis    hellp syndrome    pemphigus vulgaris    diabetic neuropathy

    4 diseases from the University of Copenhagen DISEASES database for MAPK14:
    Arthritis     Cancer     Vascular disease     Neurodegenerative disease

    MAPK14 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MAPK14 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 74.1 152 10783388 (2), 15257094 (2), 16469115 (2), 18501892 (2) (see all 99)
    inflammation 68.4 72 9069290 (1), 12354421 (1), 12542980 (1), 16442754 (1) (see all 66)
    tumors 61 167 10783388 (2), 15257094 (2), 11165942 (2), 20413844 (2) (see all 99)
    shock 55.9 81 12077134 (4), 11710946 (2), 12614460 (2), 16955245 (2) (see all 65)
    rheumatoid arthritis 46.7 28 12833650 (3), 19180516 (2), 15778394 (1), 16702443 (1) (see all 21)
    atherosclerosis 45.3 9 18055523 (1), 18830681 (1), 15809308 (1), 15155098 (1) (see all 7)
    cancer 41.1 45 18060783 (3), 15102355 (2), 12790339 (2), 14598883 (1) (see all 37)
    colon cancer 40.3 10 19845689 (2), 18444174 (1), 16982754 (1), 16715142 (1) (see all 9)
    neurodegeneration 29.6 3 12528314 (1), 11060807 (1), 14552880 (1)
    pulmonary disease chronic obstructive 29.5 4 19880675 (1), 17959643 (1), 20093202 (1), 19004925 (1)

    Genetic Association Database (GAD): MAPK14
    Human Genome Epidemiology (HuGE) Navigator: MAPK14 (20 documents)

    Export disorders for MAPK14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK14 gene, integrated from 10 sources (see all 3300):
    (articles sorted by number of sources associating them with MAPK14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. (PubMed id 7997261)1, 2, 3 Lee J.C.... Young P.R. (Nature 1994)
    2. Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2. (PubMed id 10838079)1, 2, 9 Sanz V.... Crespo P. (FEBS Lett. 2000)
    3. Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase. (PubMed id 16342939)1, 2, 9 Sullivan J.E.... Ward W.H. (Biochemistry 2005)
    4. Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4. (PubMed id 10727080)1, 2, 9 Herbison C.E.... Price P. (DNA Seq. 1999)
    5. Molecular cloning of human p38 MAP kinase. (PubMed id 7696354)1, 2, 9 Han J.... Ulevitch R.J. (Biochim. Biophys. Acta 1995)
    6. Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. (PubMed id 17255097)1, 2, 9 ter Haar E.... Lepre C. (J. Biol. Chem. 2007)
    7. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. (PubMed id 11847341)1, 2, 9 Ge B....Han J. (Science 2002)
    8. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. (PubMed id 8622669)1, 2, 9 Raingeaud J.... Davis R.J. (Mol. Cell. Biol. 1996)
    9. Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. (PubMed id 20188673)1, 2, 9 Xu P. and Derynck R. (Mol. Cell 2010)
    10. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. (PubMed id 11896401)1, 2, 9 Pargellis C.... Regan J. (Nat. Struct. Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1432 HGNC: 6876 AceView: MAPK14 Ensembl:ENSG00000112062 euGenes: HUgn1432
    ECgene: MAPK14 Kegg: 1432 H-InvDB: MAPK14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPK14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK14 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/P38_mitogen-activated_protein_kinases

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPK14 gene:
    Search GeneIP for patents involving MAPK14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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