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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK14 Gene

protein-coding   GIFtS: 73
GCID: GC06P035995

mitogen-activated protein kinase 14


(Previous symbols: CSPB1, CSBP1, CSBP2)
 Explore 191 diseases affiliated with
MAPK14 via
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 Human Malady Compendium 
Biological research products
for MAPK14    

Aliases
for MAPK14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase 141 2     MAP Kinase P38 Alpha2 3
CSBP11 2 3 5     MAX-Interacting Protein 22 3
CSBP21 2 3     EC 2.7.11.243 8
CSPB11 2 3     EXIP2
Mxi21 2     RK2
PRKM141 2     Csaids Binding Protein2
PRKM151 2     Cytokine Suppressive Anti-Inflammatory Drug Binding Protein2
P381     P38 MAP Kinase2
Cytokine Suppressive Anti-Inflammatory Drug-Binding Protein2 3     P38 Mitogen Activated Protein Kinase2
MAP Kinase MXI22 3     P38ALPHA1
Mitogen-Activated Protein Kinase P38 Alpha2 3     P38alpha Exip2
Stress-Activated Protein Kinase 2a2 3     MXI23
CSBP2 3     SAPK2a3
SAPK2A2 3     MAPK 143
CSAID-Binding Protein2 3     EC 2.7.118
MAP Kinase 142 3     

External Ids:    HGNC: 68761   Entrez Gene: 14322   Ensembl: ENSG000001120627   OMIM: 6002895   UniProtKB: Q165393   

Export aliases for MAPK14 gene to outside databases

Previous GC identifers: GC06P035997 GC06P036042 GC06P036103 GC06P035715


Summaries
for MAPK14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPK14:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. This kinase is activated by various environmental stresses
and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its
autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this
kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53,
which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in
genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have
been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by
extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of
transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that
they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated
through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly
phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and
STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play
important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by
inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase
targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the
post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is
important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38
MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein
kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the
cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of
TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar
way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit
the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane
protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms
that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory
cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors.
Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli,
p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for
ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and
cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into
the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1
translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and
activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH,
DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by
regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response,
such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10'
(H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic
NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C
which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation.
Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38
MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of
phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not
seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose
deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H,
stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in
the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis,
through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and
only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates
S100A9 at 'Thr-113'

summary for MAPK14:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK14


Genomic Views
for MAPK14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK14 gene promoter:
         MEF-2A   AP-1   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MAPK14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3-p21.2   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.3-p21.2

MAPK14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK14 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P035995:  view genomic region     (about GC identifiers)

Start:
 35,995,454 bp from pter      End:
 36,079,013 bp from pter
Size:
 83,560 bases      Orientation:
 plus strand

Proteins
for MAPK14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 14  
Size: 360 amino acids; 41293 Da
Cofactor: Magnesium
Subunit: Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR (By similarity). This
interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation (By similarity). Interacts with SPAG9
and GADD45A (By similarity). Interacts with CDC25B, CDC25C, DUSP1, DUSP10, DUSP16, NP60, SUPT20H and TAB1. Interacts
with casein kinase II subunits CSNK2A1 and CSNK2B
Subcellular location: Cytoplasm. Nucleus
6/193 PDB 3D structures from and Proteopedia for MAPK14 (see all 193):
1A9U (3D)        1BL6 (3D)        1BL7 (3D)        1BMK (3D)        1DI9 (3D)        1IAN (3D)    
Secondary accessions: A6ZJ92 A8K6P4 B0LPH0 O60776 Q13083 Q14084 Q8TDX0
Alternative splicing: 4 isoforms:  Q16539-1   Q16539-2   Q16539-3   Q16539-4   

Explore the universe of human proteins at neXtProt for MAPK14: NX_Q16539

Post-translational modifications:

  • Dually phosphorylated on Thr-180 and Tyr-182 by the MAP2Ks MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6 in response to
    • inflammatory citokines, environmental stress or growth factors, which activates the enzyme. Dual phosphorylation can
    also be mediated by TAB1-mediated autophosphorylation. TCR engagement in T-cells also leads to Tyr-323 phosphorylation
    by ZAP70. Dephosphorylated and inactivated by DUPS1, DUSP10 and DUSP161
  • Acetylated at Lys-53 and Lys-152 by KAT2B and EP300. Acetylation at Lys-53 increases the affinity for ATP and enhances
    • kinase activity. Lys-53 and Lys-152 are deacetylated by HDAC31
  • Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16539

    • 4/34 DME Specific Peptides for MAPK14 (Q16539) (see all 34)
     LKYIHSA  DTKTGLR  AHAYFAQ  FVPPPLD 

    MAPK14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001306.1  NP_620581.1  NP_620582.1  NP_620583.1  

    ENSEMBL proteins: 
     ENSP00000229795   ENSP00000229794   ENSP00000419837   ENSP00000417531   ENSP00000308669  
     ENSP00000417065   ENSP00000419141  
    Reactome Protein details: Q16539
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAPK14 Protein
    R&D Systems Recombinant & Natural Proteins for MAPK14 (p38 alpha)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 3): MAPK14
    OriGene Protein Over-expression Lysate (see all 4): MAPK14
    OriGene Custom Protein Services for MAPK14 
    GenScript Custom Purified and Recombinant Proteins Services for MAPK14
    Novus Biologicals MAPK14 Proteins
    Novus Biologicals MAPK14 Lysates
    Sino Biological Recombinant Protein for MAPK14
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAPK14

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005623cell ----
    GO:0005625soluble fraction ----
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--


    MAPK14 for ontologies           About GeneDecksing



    MAPK14 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK14
    R&D Systems Antibodies for MAPK14 (p38 alpha)
    Cell Signaling Technology (CST) Antibodies for MAPK14  (p38-alpha)
    OriGene Antibodies (see all 5): MAPK14
    OriGene Custom Antibody Services for MAPK14 
    GenScript Custom Superior Antibodies Services for MAPK14
    Novus Biologicals MAPK14 Antibodies
    Abcam antibodies for MAPK14 
    Uscn Antibodies for MAPK14
    ThermoFisher Antibody for MAPK14

    Assay Products for MAPK14: 
    EMD Millipore Kits and Assays for the Analysis of MAPK14
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for MAPK14 (p38 alpha)         (see all)
    GenScript Custom Assay Services for MAPK14
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK14 (p38-alpha)
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAPK14

    Protein Domains /
    Families
    for MAPK14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPK14 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q16539

    ProtoNet protein and cluster: Q16539

    2 Blocks protein families:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAPK14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
    MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by
    extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of
    transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that
    they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated
    through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly
    phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and
    STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play
    important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by
    inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase
    targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the
    post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is
    important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38
    MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein
    kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the
    cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of
    TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar
    way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit
    the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane
    protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms
    that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory
    cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors.
    Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli,
    p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for
    ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and
    cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into
    the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1
    translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and
    activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH,
    DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by
    regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response,
    such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10'
    (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic
    NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C
    which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation.
    Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38
    MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of
    phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not
    seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose
    deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H,
    stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in
    the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis,
    through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and
    only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates
    S100A9 at 'Thr-113'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by cell stresses such as DNA damage, heat shock, osmotic shock, anisomycin and sodium
    arsenite, as well as pro-inflammatory stimuli such as bacterial lipopolysaccharide (LPS) and interleukin-1. Activation
    occurs through dual phosphorylation of Thr-180 and Tyr-182 by either of two dual specificity kinases, MAP2K3/MKK3 or
    MAP2K6/MKK6, and potentially also MAP2K4/MKK4, as well as by TAB1-mediated autophosphorylation. MAPK14 phosphorylated
    on both Thr-180 and Tyr-182 is 10-20-fold more active than MAPK14 phosphorylated only on Thr-180, whereas MAPK14
    phosphorylated on Tyr-182 alone is inactive. whereas Thr-180 is necessary for catalysis, Tyr-182 may be required for
    auto-activation and substrate recognition. Phosphorylated at Tyr-323 by ZAP70 in an alternative activation pathway in
    response to TCR signaling in T-cells. This alternative pathway is inhibited by GADD45A. Inhibited by dual specificity
    phosphatases, such as DUSP1, DUSP10, and DUSP16. Specifically inhibited by the binding of pyridinyl-imidazole
    compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID). Isoform Mxi2 is 100-fold less sensitive to
    these agents than the other isoforms and is not inhibited by DUSP1. Isoform Exip is not activated by MAP2K6. SB203580
    is an inhibitor of MAPK14

         Genatlas biochemistry entry for MAPK14:
    mitogen-activated protein kinase14

    Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target MAPK14:
    hsa-mir-124 (MIRT002610), hsa-mir-24 (MIRT002950)

    OriGene 3'-UTR Clone (see all 4): MAPK14
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK14
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK14 (see all 46):
    hsa-miR-124* hsa-miR-3616-5p hsa-miR-128 hsa-miR-16-1* hsa-miR-3142 hsa-miR-124 hsa-miR-629* hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK14 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK14 (see all 7)
    OriGene shRNA RFP: MAPK14
    OriGene siRNA: MAPK14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK14

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPK14

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK14 (see all 9)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK14 (see all 7)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK14 (NM_139012)
    Sino Biological Human cDNA Clone for MAPK14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK14 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAPK14
    Search LifeMap BioReagents cell lines for MAPK14

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK14

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004707MAP kinase activity IDA--
    GO:0004708MAP kinase kinase activity TAS10706854
    GO:0005515protein binding IPI19776015


    MAPK14 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for MAPK14:
     Decreased number of cells in m  Decreased substrate adherent c  Decreased telomerase activity  Decreased viability after Chla 
     High actin ratio cells 

    Animal Models:
         Mouse knock-outs for MAPK14: Mapk14tm1Mms Mapk14tm1Gab Mapk14tm1Mka Mapk14tm1.1Otsu
         15/17 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Mapk14) (see all 17):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  nervous system  normal  reproductive system  respiratory system 

    MAPK14 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPK14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/162 super-pathways (see all 162) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    8/10 pathways (see all 10)
    		G-protein signaling Ras family GTPases in kinase cascades (scheme)1.00
    		Activation of the AP-1 family of transcription factors0.33
    		G-protein signaling_Ras family GTPases in kinase cascades (scheme)1.00
    		Immune response_Role of integrins in NK cells cytotoxicity0.28
    		MAPK Cascade0.44
    		Immune response Role of integrins in NK cells cytotoxicity0.28
    		Immune response_Oncostatin M signaling via MAPK in human cells0.39
    		Oncostatin M Signaling Pathway0.15
    3ErbB4 Pathway
    8/10 pathways (see all 10)
    		ErbB4 Pathway1.00
    		LPS Stimulated MAPK Signaling0.36
    		ErbB Family Pathway0.59
    		VEGF Signaling Pathway0.35
    		Prolactin Signaling0.54
    		TREM1 Pathway0.32
    		IL-2 Pathway0.46
    		HMGB1 Pathway0.32
    44-1BB Pathway
    		4-1BB Pathway1.00
    		PKR Pathway0.36
    		CD40 Signaling0.54
    		NF-KappaB Activation by EBV0.31
    		CMV and MAPK Pathways0.38
    		SUMO Pathway0.30
    5Toll Comparative Pathway
    		Toll Comparative Pathway1.00
    		Immune response MIF in innate immunity response0.46
    		TLR-TRIF Pathway0.61
    		IL-1 Pathway0.39
    		Immune response_MIF in innate immunity response0.46
    		iNOS Signaling0.34

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/29 EMD Millipore Pathways for MAPK14 (see all 29)
        Development A1 receptor signaling
    Immune response MIF in innate immunity response
    G-protein signaling G-Protein alpha-12 signaling pathway
    Development TGF-beta receptor signaling
    Immune response CCR3 signaling in eosinophils

    3 R&D Systems Pathways for MAPK14
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways
    TGF-beta Signaling Pathways

    5/94 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK14 (see all 94)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK14
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK14
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    5/32 GeneGo (Thomson Reuters) Pathways for MAPK14 (see all 32)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    Development Endothelin-1/EDNRA signaling
    Immune response IL-12-induced IFN-gamma production

    5/62 BioSystems Pathways for MAPK14 (see all 62) 
        Oncostatin M Signaling Pathway
    Senescence and Autophagy
    EGFR1 Signaling Pathway
    Parkinsons Disease Pathway
    AGE/RAGE pathway

    5/56        Reactome Pathways for MAPK14 (see all 56)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Platelet homeostasis
    p38MAPK events
    Activation of p38 alpha/beta MAPK

    2 PharmGKB Pathways for MAPK14
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/22         Kegg Pathways  (Kegg details for MAPK14) (see all 22):
        MAPK signaling pathway
    VEGF signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway


    MAPK14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/437 Interacting proteins for MAPK14 (Q165391, 2, 3 ENSP000002297944) via UniProtKB, MINT, STRING, and/or I2D (see all 437)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZFP36L1Q073521, 2, 3, ENSP000003373864EBI-73946,EBI-721823 MINT-66629 I2D: score=6 STRING: ENSP00000337386
    SUPT20HQ8NEM71, 2, 3, ENSP000002188944EBI-73946,EBI-946984 MINT-7557407 I2D: score=5 STRING: ENSP00000218894
    FAM48AQ8NEM71, 2, 3EBI-73946,EBI-946984 MINT-7557407 I2D: score=5 
    MAPK3P273612, 3, ENSP000002630254MINT-8092346 MINT-8092357 MINT-8092337 I2D: score=5 STRING: ENSP00000263025
    TAB1Q157502, 3, ENSP000002161604MINT-17883 MINT-8260174 MINT-17884 I2D: score=5 STRING: ENSP00000216160
    About this table

    Gene Ontology (GO): 5/61 biological process terms (GO ID links to tree view) (see all 61):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IEA--
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity TAS--
    GO:0000902cell morphogenesis IEA--
    GO:0001525angiogenesis IEA--


    MAPK14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPK14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK14 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK14:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MAPK14 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RWJ 67657 Potent, selective p38alpha and p38beta inhibitor [215303-72-3]
    SB 239063 Potent, selective p38 MAPK inhibitor; orally active [193551-21-2]
    TAK 715Potent p38 MAPK inhibitor; anti-inflammatory[303162-79-0]
    EO 1428Selective inhibitor of p38alpha and p38beta2[321351-00-2]
    SB 203580Selective inhibitor of p38 MAPK[152121-47-6]

    3 HMDB Compounds for MAPK14    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    10/50 DrugBank Compounds for MAPK14 (see all 50)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One-- --target--17139284 17016423 10592235
    1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea-- --target--17139284 17016423 10592235
    3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine-- --target--17139284 17016423 10592235
    3-(Benzyloxy)Pyridin-2-Amine-- --target--17139284 17016423 10592235
    4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline-- --target--17139284 17016423 10592235
    Inhibitor of P38 Kinase-- --target--17139284 17016423 10592235
    N-[(3z)-5-Tert-Butyl-2-Phenyl-1,2-Dihydro-3h-Pyrazol-3-Ylidene]-N'-(4-Chlorophenyl)Urea-- --target--17139284 17016423 10592235
    SB220025-- --target--17139284 17016423 10592235
    1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One-- --target--17139284 17016423
    1-(5-Tert-Butyl-2-P-Tolyl-2h-Pyrazol-3-Yl)-3-[4-(2-Morpholin-4-Yl-Ethoxy)-Naphthalen-1-Yl]-Urea-- --target--17139284 17016423

    10/140 Novoseek chemical compound relationships for MAPK14 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 97.5 706 10702313 (3), 11524243 (3), 19959817 (3), 16838116 (3) (see all 99)
    sp 600125 90 71 15964311 (2), 12697041 (1), 16440327 (1), 16433890 (1) (see all 64)
    pd 98,059 90 160 12663671 (2), 10794715 (2), 10601300 (1), 10082133 (1) (see all 99)
    pyridinylimidazole 87.2 38 9224565 (5), 14594946 (3), 9827991 (2), 10878289 (2) (see all 24)
    pd 169316 87 40 11141234 (3), 11811942 (2), 15572410 (2), 11500937 (2) (see all 30)
    anisomycin 81 65 18060783 (3), 16683917 (2), 15054109 (2), 8761479 (2) (see all 44)
    rwj 67657 75.5 1 12962514 (1)
    ly294002 73.7 39 17303382 (2), 12204874 (1), 12781867 (1), 15547762 (1) (see all 32)
    phosphatidylinositol 72.2 120 18036649 (3), 9605580 (2), 15082758 (2), 15024026 (2) (see all 99)
    wortmannin 71.3 27 9605580 (1), 18437163 (1), 19377829 (1), 11510895 (1) (see all 25)

    Search CenterWatch for drugs/clinical trials and news about MAPK14 / MK14 

    Transcripts
    for MAPK14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPK14 gene (4 alternative transcripts): 
    NM_001315.2  NM_139012.2  NM_139013.2  NM_139014.2  

    Unigene Cluster for MAPK14:

    Mitogen-activated protein kinase 14
    Hs.485233  [show with all ESTs]
    Unigene Representative Sequence: NM_001315
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229795(uc003olp.3 uc003olq.3 uc003olr.3 uc011dti.2)
    ENST00000229794(uc003olo.3) ENST00000468133 ENST00000496250(uc011dth.2)
    ENST00000491957 ENST00000310795 ENST00000474429 ENST00000472333 ENST00000490379


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): MAPK14
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK14
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK14 (see all 46):
    hsa-miR-124* hsa-miR-3616-5p hsa-miR-128 hsa-miR-16-1* hsa-miR-3142 hsa-miR-124 hsa-miR-629* hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK14 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK14 (see all 7)
    OriGene shRNA RFP: MAPK14
    OriGene siRNA: MAPK14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK14
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK14 (see all 9)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK14 (see all 7)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK14 (NM_139012)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK14 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPK14
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPK14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK14

    Additional cDNA sequence: 

    AB074150.1 AF100544.1 AK291709.1 AK303414.1 BC000092.1 BC031574.1 BT006933.1 CR536505.1 
    FJ032367.1 FJ032368.1 L35263.1 L35264.1 Z25432.1 

    15 DOTS entries:

    DT.100843331  DT.118633  DT.91755525  DT.121316865  DT.100732109  DT.121316903  DT.121316935  DT.70101617 
    DT.428535  DT.100660365  DT.101962528  DT.91755514  DT.91755516  DT.100038032  DT.95252849 

    24/308 AceView cDNA sequences (see all 308):

    BM849403 AW151097 AA479655 AI471658 NM_139012 CB155348 BU622697 BF154903 
    N53834 BG251020 BU782912 BQ014266 AA113051 AA680135 CB053619 BM718552 
    AA948637 NM_139014 BU631727 AU186028 BM979114 CR536505 BM758641 AW572148 

    GeneLoc Exon Structure


    Expression
    for MAPK14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACTTGGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPK14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudHepatoblastsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAPK14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK14

    SOURCE GeneReport for Unigene cluster: Hs.485233

    UniProtKB/Swiss-Prot: MK14_HUMAN, Q16539
    Tissue specificity: Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver
    and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK14 (see all 18): 
              Antiviral Response in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPK14
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPK14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK14
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK14

    Orthologs
    for MAPK14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK14 gene from 9/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAPK141 mitogen-activated protein kinase 14 82.04(n)
    92.5(a)    		   421183  XM_001232615.1  XP_001232616.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPK146
    		 --
    		 92(a)
    		 1 ↔ 1
    		 GL343382.1(640903-679471)
    African clawed frog
    (Xenopus laevis)    		 Amphibia mapk14a-prov2 Mitogen-activated protein kinase 2 78.66(n)    BC056064.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AB030897.12   -- 78.23(n)   65237  AB030897.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta p38b1 , 3 regulation of BMP signaling pathway protein
    serine/threonine more3
    CG7393-PA1    		 69(a)
    (best of 3)3
    64.19(n)1
    70(a)1    		   34D13
    347801  NM_058013.41  NP_477361.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea pmk-11 , 3 ser/thr kinases3
    Protein PMK-11    		 65(a)
    (best of 6)3
    60.11(n)1
    64.04(a)1    		   IV(8148976-8149980)3
    1917431  NM_068964.21  NP_501365.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes HOG1(YLR113W)4
    HOG11    		 Mitogen-activated protein kinase involved in osmoregulation; more4
    Hog1p1    		 56.05(n)1
    53.57(a)1    		   12(371620-372927)4
    8508031, 4  NP_013214.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MPK31 extracellular signal-regulated kinase 1/2 54(n)
    46.49(a)    		   823706  NM_114433.2  NP_190150.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g02858001 hypothetical protein 53.21(n)
    47.59(a)    		   4332475  NM_001056305.1  NP_001049770.1 


    ENSEMBL Gene Tree for MAPK14 (if available)
    TreeFam Gene Tree for MAPK14 (if available) 

    Paralogs
    for MAPK14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK14 gene
    MAPK92  MAPK122  MAPK132  MAPK112  MAPK102  MAPK82  
    18/107 SIMAP similar genes for MAPK14 using alignment to 7 protein entries:     MK14_HUMAN (see all proteins) (see all similar genes):
    MAPK11    MAPK13    MAPK12    DKFZp686M02159    MAPK8    MAPK9
    MAPK10    MAPK7    MAPK1    DKFZp686O0215    MAPK3    NLK
    MAPK4    CAMKK2    MAPK6    PRPF4B    AKT2    MAPK15

    MAPK14 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPK14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1581 NCBI SNPs in MAPK14 are shown (see all 1581)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1905316871,2
    		--35993456(+) TTCACC/TCTCCA 7 -- us2k10--------
    rs1834477021,2
    		--35993547(+) CCTAAA/GCTACA 7 -- us2k10--------
    rs1495381991,2
    		--35993552(+) GCTACA/GTTGGA 7 -- us2k10--------
    rs1441304401,2
    		--35993734(+) TTGGGA/GCAAGA 7 -- us2k10--------
    rs1399351081,2
    		--35993779(+) CACAAA/GATAGA 7 -- us2k10--------
    rs1888959241,2
    		--35993854(+) AAGAGA/GATGAG 7 -- us2k10--------
    rs1466801891,2
    		C,--35993893(+) ACAAG-/CTTTAG 7 -- us2k10--------
    rs37619801,2
    		C,F,H,--35993906(-) ACCTAT/CGCCTA 7 -- us2k128Minor allele frequency- C:0.17NA EA NS WA 3172
    rs1467161211,2
    		--35994034(+) TGGAAC/TTGAGG 7 -- us2k10--------
    rs37619791,2
    		C,F,A,H,--35994088(-) AGAATA/CGGGCA 7 -- us2k119Minor allele frequency- C:0.18NS EA NA WA 2432

    HapMap Linkage Disequilibrium report for MAPK14 (35995454 - 36079013 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAPK14: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAPK14
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK14

    Disorders / Diseases
    for MAPK14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPK14 for disorders           About GeneDecksing

    OMIM gene information: 600289    OMIM disorders: --

    20/191 diseases for MAPK14 (see all 191):    About MalaCards
    fibrodysplasia ossificans progressiva    neurodegeneration    doxorubicin induced cardiomyopathy    amyotrophic lateral sclerosis (als)
    amyotrophic lateral sclerosis    dengue hemorrhagic fever    clostridium difficile    pre-eclampsia
    pemphigus foliaceus    severe acute respiratory syndrome    soft tissue sarcoma    type 2 diabetes mellitus
    pemphigus vulgaris    hemorrhagic fever    diabetes mellitus    inflammatory bowel disease
    lateral sclerosis    japanese encephalitis    oral cavity cancer    ataxia telangiectasia

    3 diseases from the University of Copenhagen DISEASES database for MAPK14:
    Arthritis     Vascular disease     Cancer

    10/94 Novoseek disease relationships for MAPK14 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 74.1 152 10783388 (2), 15257094 (2), 16469115 (2), 18501892 (2) (see all 99)
    inflammation 68.4 72 9069290 (1), 12354421 (1), 12542980 (1), 16442754 (1) (see all 66)
    tumors 61 167 10783388 (2), 15257094 (2), 11165942 (2), 20413844 (2) (see all 99)
    shock 55.9 81 12077134 (4), 11710946 (2), 12614460 (2), 16955245 (2) (see all 65)
    rheumatoid arthritis 46.7 28 12833650 (3), 19180516 (2), 15778394 (1), 16702443 (1) (see all 21)
    atherosclerosis 45.3 9 18055523 (1), 18830681 (1), 15809308 (1), 15155098 (1) (see all 7)
    cancer 41.1 45 18060783 (3), 15102355 (2), 12790339 (2), 14598883 (1) (see all 37)
    colon cancer 40.3 10 19845689 (2), 18444174 (1), 16982754 (1), 16715142 (1) (see all 9)
    neurodegeneration 29.6 3 12528314 (1), 11060807 (1), 14552880 (1)
    pulmonary disease chronic obstructive 29.5 4 19880675 (1), 17959643 (1), 20093202 (1), 19004925 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAPK14 (20 documents)

    Export disorders for MAPK14 gene to outside databases

    Publications
    for MAPK14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK14 gene, integrated from 9 sources (see all 3202):
    (articles sorted by number of sources associating them with MAPK14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. (PubMed id 7997261)1, 2, 3 Lee J.C.... Young P.R. (1994)
    2. Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2. (PubMed id 10838079)1, 2, 9 Sanz V.... Crespo P. (2000)
    3. Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase. (PubMed id 16342939)1, 2, 9 Sullivan J.E....Ward W.H. (2005)
    4. Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4. (PubMed id 10727080)1, 2, 9 Herbison C.E.... Price P. (1999)
    5. Molecular cloning of human p38 MAP kinase. (PubMed id 7696354)1, 2, 9 Han J.... Ulevitch R.J. (1995)
    6. Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. (PubMed id 17255097)1, 2, 9 ter Haar E....Lepre C. (2007)
    7. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. (PubMed id 11847341)1, 2, 9 Ge B....Han J. (2002)
    8. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. (PubMed id 8622669)1, 2, 9 Raingeaud J.... Davis R.J. (1996)
    9. Direct activation of TACE-mediated ectodomain sheddin g by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. (PubMed id 20188673)1, 2, 9 Xu P. and Derynck R. (2010)
    10. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. (PubMed id 11896401)1, 2, 9 Pargellis C....Regan J. (2002)

    External Searches for MAPK14 gene

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    Genome Databases showing MAPK14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1432 HGNC: 6876 AceView: MAPK14 Ensembl:ENSG00000112062 euGenes: HUgn1432
    ECgene: MAPK14 Kegg: 1432 H-InvDB: MAPK14

    Other Databases showing MAPK14 gene

    (According to HUGE)
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    Specialized Databases showing MAPK14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK14 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/P38_mitogen-activated_protein_kinases

    Intellectual Property
    for MAPK14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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