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MAPK13 Gene

protein-coding   GIFtS: 71
GCID: GC06P036095

Mitogen-Activated Protein Kinase 13


(Previous symbol: PRKM13)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 131 2     MAP Kinase P38 Delta2 3
PRKM131 2 3     MAPK 132 3
Mitogen-Activated Protein Kinase P38 Delta2 3     EC 2.7.11.243 8
Stress-Activated Protein Kinase 42 3     MAPK-132
SAPK42 3     p38delta2
MAP Kinase 132 3     EC 2.7.118

External Ids:    HGNC: 68751   Entrez Gene: 56032   Ensembl: ENSG000001567117   OMIM: 6028995   UniProtKB: O152643   

Export aliases for MAPK13 gene to outside databases

Previous GC identifers: GC06P036100 GC06P036145 GC06P036129 GC06P035818


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK13 Gene:
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration
point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as
proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase
and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the
transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript
variants have been observed for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for MAPK13 Gene:
MAPK13 (mitogen-activated protein kinase 13) is a protein-coding gene. Diseases associated with MAPK13 include shigellosis, and toxoplasmosis. GO annotations related to this gene include MAP kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is MAPK9.

UniProtKB/Swiss-Prot: MK13_HUMAN, O15264
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins
and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less
studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated
through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein
translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through
phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of
CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin
tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid
MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during
regulation of insulin secretion in pancreatic beta cells

Gene Wiki entry for MAPK13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK13 gene promoter:
         SRF   SREBP-1c   SRF (504 AA)   Lmo2   STAT5A   AP-4   SREBP-1b   C/EBPalpha   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAPK13 promoter sequence
   Search Chromatin IP Primers for MAPK13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

MAPK13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK13 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036095:  view genomic region     (about GC identifiers)

Start:
36,095,586 bp from pter      End:
36,107,842 bp from pter
Size:
12,257 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MK13_HUMAN, O15264 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 13  
Size: 365 amino acids; 42090 Da
Cofactor: Magnesium
Subunit: Interacts with MAPK8IP2
4 PDB 3D structures from and Proteopedia for MAPK13:
3COI (3D)        4EXU (3D)        4EYJ (3D)        4EYM (3D)    
Secondary accessions: O14739 O15124 Q6FI46 Q9UNU0

Explore the universe of human proteins at neXtProt for MAPK13: NX_O15264

Explore proteomics data for MAPK13 at MOPED

Post-translational modifications: 

  • Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which
    activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPK13 (O15264) (see all 26)
     ILDFGLA  VVHRDLK  LDFGLAR  LKYIHSA 


    See MAPK13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002745.1  
    ENSEMBL proteins: 
     ENSP00000211287   ENSP00000362864   ENSP00000362866   ENSP00000362871  
    Reactome Protein details: O15264

    MAPK13 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAPK13 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MAPK13
    OriGene Purified Protein for MAPK13
    OriGene Protein Over-expression Lysate for MAPK13
    OriGene MassSpec for MAPK13
    OriGene Custom Protein Services for MAPK13
    GenScript Custom Purified and Recombinant Proteins Services for MAPK13
    Novus Biologicals MAPK13 Proteins
    Novus Biologicals MAPK13 Lysates
    Sino Biological Recombinant Protein for MAPK13
    Sino Biological Cell Lysate for MAPK13
    ProSpec Recombinant Protein for MAPK13
    Cloud-Clone Corp. Proteins for MAPK13

    MAPK13 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK13
    R&D Systems Antibodies for MAPK13 (p38 delta)
    Cell Signaling Technology (CST) Antibodies for MAPK13  (P38D)
    OriGene Antibodies for MAPK13
    OriGene Custom Antibody Services for MAPK13
    Novus Biologicals MAPK13 Antibodies
    Abcam antibodies for MAPK13
    Cloud-Clone Corp. Antibodies for MAPK13
    ThermoFisher Antibodies for MAPK13
    LSBio Antibodies in human, mouse, rat for MAPK13

    MAPK13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAPK13
    R&D Systems ELISAs for MAPK13 (p38 delta)         (see all)
    GenScript Custom Assay Services for MAPK13
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK13 (P38D)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK13
    Cloud-Clone Corp. CLIAs for MAPK13


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 13
    p38 subfamily
    Mitogen-activated protein kinases

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O15264

    ProtoNet protein and cluster: O15264

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK13_HUMAN, O15264
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK13_HUMAN, O15264
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
    evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
    of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins
    and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less
    studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated
    through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein
    translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through
    phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of
    CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin
    tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid
    MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during
    regulation of insulin secretion in pancreatic beta cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on threonine and tyrosine by dual specificity kinases,
    MAP2K3/MKK3, MAP2K6/MKK6, MAP2K4/MKK4 and MAP2K7/MKK7. Activation by ultraviolet radiation, hyperosmotic shock,
    anisomycin or by TNF-alpha is mediated by MAP2K3/MKK3. Inhibited by dual specificity phosphatase DUSP1

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA12244047
    GO:0004707MAP kinase activity IDA9218798
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI19135240
         
    MAPK13 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for MAPK13:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  G0/1 arrest  Increased G1 DNA content 
     Increased mitotic index  Wnt reporter downregulated 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mapk13):
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  muscle  no phenotypic analysis 
     normal 

    MAPK13 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAPK13: Mapk13tm1Lex Mapk13tm1Cnd Mapk13tm2.1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK13
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPK13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK13

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MAPK13 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate MAPK13:
    hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-1252 hsa-miR-3909 hsa-miR-449a hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmidMAPK13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPK13
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK13

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK13 (see all 8)
    OriGene ORF clones in mouse, rat for MAPK13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK13 (NM_002754)
    Sino Biological Human cDNA Clone for MAPK13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK13

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK13
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    MAPK13 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK13 About   (see all 102)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Fc epsilon RI signaling pathway0.41
    VEGF - VEGF R2 Signaling Pathways0.35
    2Toll Comparative Pathway
    Toll Comparative Pathway0.61
    IL-1 Pathway0.39
    TLR-TRIF Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    4Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.68
    5MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for MAPK13 (see all 8)
        Inflammasome Activation Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK13 (see all 89)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK13
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK13
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MAPK13 (see all 24)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway

    Selected BioSystems Pathways for MAPK13 (see all 7)
        MAPK signaling pathway
    Insulin Signaling
    Parkinsons Disease Pathway
    Toll-like receptor signaling pathway
    RB in Cancer

    4 Sino Biological Pathways for MAPK13
        Non-Canonical Wnt Pathway
    p53 Pathway
    VEGF Signaling
    TGF-beta Signaling Pathway

    3 Reactome Pathways for MAPK13
        p38MAPK events
    NOD1/2 Signaling Pathway
    DSCAM interactions

    1 PharmGKB Pathway for MAPK13
        VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for MAPK13) (see all 33):
        MAPK signaling pathway
    Rap1 signaling pathway
    FoxO signaling pathway
    Adrenergic signaling in cardiomyocytes
    VEGF signaling pathway


    MAPK13 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK13: 
              Cytoskeleton Regulators in human mouse rat
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK13 (O152641, 2, 3 ENSP000002112874) via UniProtKB, MINT, STRING, and/or I2D (see all 348)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKD1Q151391, 3EBI-2116951,EBI-1181072 I2D: score=1 
    SMAD4Q134852, 3, ENSP000003415514MINT-61974 I2D: score=3 STRING: ENSP00000341551
    ANKLE2Q86XL33, ENSP000003506864I2D: score=2 STRING: ENSP00000350686
    MAP3K4Q9Y6R43, ENSP000003759864I2D: score=2 STRING: ENSP00000375986
    EEF2P136393, ENSP000003079404I2D: score=1 STRING: ENSP00000307940
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IDA9218798
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006468protein phosphorylation ----
    GO:0006950response to stress IDA9218798

    MAPK13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAPK13 (MK13)

    3 HMDB Compounds for MAPK13    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    6 Novoseek inferred chemical compound relationships for MAPK13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyridinylimidazole 88.2 1 9374491 (1)
    sb 203580 54.2 2 17481747 (1), 17256148 (1)
    12-o-tetradecanoylphorbol 13-acetate 41.2 2 19458068 (1)
    okadaic acid 32.8 2 17256148 (2)
    serine 17.1 1 9199504 (1)
    atp 0 1 9624152 (1)



    MAPK13 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAPK13 gene: 
    NM_002754.4  

    Unigene Cluster for MAPK13:

    Mitogen-activated protein kinase 13
    Hs.178695  [show with all ESTs]
    Unigene Representative Sequence: NM_002754
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476951 ENST00000211287(uc003ols.3 uc003olt.3) ENST00000373759
    ENST00000490334 ENST00000373761 ENST00000373766

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate MAPK13:
    hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-1252 hsa-miR-3909 hsa-miR-449a hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmidMAPK13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAPK13
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK13
    Clone
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    OriGene clones in human, mouse for MAPK13 (see all 8)
    OriGene ORF clones in mouse, rat for MAPK13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK13 (NM_002754)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK13
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAPK13
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK13
      QuantiTect SYBR Green Assays in human, mouse, rat MAPK13
      QuantiFast Probe-based Assays in human, mouse, rat MAPK13

    Additional mRNA sequence: 

    AB451221.1 AB451344.1 AF004709.1 AF015256.1 AF092535.1 AF100546.1 AK222922.1 AK308018.1 
    BC000433.2 BC001641.2 BC004428.1 BC085196.1 BT007221.1 CR536490.1 CR541687.1 NR_072996.1 
    U93232.1 Y10488.1 

    13 DOTS entries:

    DT.75139262  DT.97838957  DT.121396393  DT.75184240  DT.100022242  DT.99970880  DT.100816810  DT.100816808 
    DT.75143119  DT.92030945  DT.92427717  DT.100816806  DT.97843903 

    Selected AceView cDNA sequences (see all 132):

    CR595896 BM680925 CR536490 AA548684 BT007221 BM726228 BG740841 AF100546 
    AW366972 BU682484 BG290544 BM973431 AA860797 BM981671 AA788736 AW366945 
    AI050988 Y10488 AA297419 CB217130 AA568285 BX460545 CR603684 BU676766 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPK13 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14
    SP1:                          -     -                                                                       -                                 
    SP2:                          -     -                                         -     -     -                 -                                 
    SP3:                          -     -                                               -     -     -           -                                 
    SP4:                                                                          -     -     -                 -                                 
    SP5:                          -     -                                         -     -     -                                                   


    ECgene alternative splicing isoforms for MAPK13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAPK13 expression in normal human tissues (normalized intensities)      MAPK13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCGCCGG
    MAPK13 Expression
    About this image


    MAPK13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Tip Cells Ureteric Bud
             Renal Collecting Duct System
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Seminiferous Tubules
    MAPK13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.178695

    UniProtKB/Swiss-Prot: MK13_HUMAN, O15264
    Tissue specificity: Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also
    present in neutrophils, CD4+ T-cells, and endothelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK13: 
              Cytoskeleton Regulators in human mouse rat
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MAPK13 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk131 , 5 mitogen-activated protein kinase 131, 5 88.13(n)1
    93.15(a)1
      17 (15.00 cM)5
    264151  NM_011950.21  NP_036080.21 
     287693075 
    chicken
    (Gallus gallus)
    Aves MAPK131 mitogen-activated protein kinase 13 76.26(n)
    79.45(a)
      771145  XM_001234442.2  XP_001234443.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK136
    mitogen-activated protein kinase 13
    79(a)
    1 ↔ 1
    GL343382.1(590045-628318)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.30652 Transcribed sequence with weak similarity to protein more 74.32(n)    BX742715.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapk131 mitogen-activated protein kinase 13 65.63(n)
    66.76(a)
      100002318  XM_001337797.5  XP_001337833.2 


    ENSEMBL Gene Tree for MAPK13 (if available)
    TreeFam Gene Tree for MAPK13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK13 gene
    MAPK92  MAPK122  MAPK112  MAPK142  MAPK82  MAPK102  
    Selected SIMAP similar genes for MAPK13 using alignment to 6 protein entries:     MK13_HUMAN (see all proteins) (see all similar genes):
    MAPK14    MAPK12    DKFZp686M02159    MAPK11    MAPK10    MAPK8
    DKFZp686O0215    MAPK9    MAPK3    MAPK1    MAPK7    NLK
    MAPK4    MAPK15    DKFZp434M058    MAPK6    CDKL2    CDK11A

    MAPK13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MAPK13 (see all 393)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs667084171,2
    C--36017011(+) TCTCA-/A/AA  
            
    AAAAA
    2 -- int11NA 2
    rs1390215291,2
    --36096269(+) AATGAA/CGGGCA 2 -- us2k10--------
    rs1156752621,2
    F--36096338(+) CATTCA/TTTCTC 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs28158091,2
    C,F,A,H--36096357(+) TGCTGA/TTATAT 2 -- us2k123Minor allele frequency- T:0.15NS EA NA WA CSA 2339
    rs1427404451,2
    C--36096437(+) TGGCA-/CCCCAC 2 -- us2k10--------
    rs37619771,2
    C,F,A,H--36096447(-) TGAGAT/AGAGGG 2 -- us2k111Minor allele frequency- A:0.32EA NS NA CSA WA 2444
    rs28591421,2
    C,F,A--36096543(-) GGGGGT/CCCACA 2 -- us2k111Minor allele frequency- C:0.29NA WA CSA EA 372
    rs1416002961,2
    --36096544(+) GTGGGC/TCCCCG 2 -- us2k10--------
    rs77706961,2
    C,F--36096646(+) CCCCAT/CGCCTG 2 -- us2k15Minor allele frequency- C:0.23WA CSA 126
    rs1825298351,2
    --36096738(+) CCTCAC/GAGGCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPK13 (36095586 - 36107842 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAPK13: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK13
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602899    OMIM disorders: --

    Selected diseases for MAPK13 (see all 21):    About MalaCards
    shigellosis    toxoplasmosis    trypanosomiasis    chagas disease
    pertussis    leishmaniasis    lateral sclerosis    amyotrophic lateral sclerosis
    influenza    parkinson's disease    hepatitis c    tuberculosis
    hypoxia    cholangiocarcinoma    rheumatoid arthritis    arthritis
    hepatitis    endotheliitis    esophagitis    pancreatitis


    MAPK13 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for MAPK13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 23 2 17482683 (1), 14694199 (1)
    tumors 0 2 17334397 (1), 19458068 (1)

    Genetic Association Database (GAD): MAPK13
    Human Genome Epidemiology (HuGE) Navigator: MAPK13 (6 documents)

    Export disorders for MAPK13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK13 gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with MAPK13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PubMed id 9218798)1, 2, 3, 9 Goedert M.... Cohen P. (EMBO J. 1997)
    2. Molecular cloning and characterization of a novel p38 mitogen- activated protein kinase. (PubMed id 9295308)1, 2, 3, 9 Wang X.S.... Yao Z. (J. Biol. Chem. 1997)
    3. Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4. (PubMed id 10727080)1, 2, 9 Herbison C.E.... Price P. (DNA Seq. 1999)
    4. MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta. (PubMed id 18367666)1, 2, 9 Zhou X.... Burg M.B. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. (PubMed id 9374491)1, 2, 9 Jiang Y.... Han J. (J. Biol. Chem. 1997)
    6. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. (PubMed id 10201954)1, 2, 9 Hale K.K.... Manthey C.L. (J. Immunol. 1999)
    7. Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. (PubMed id 10066767)1, 2, 9 Hu M.C.-T.... Tan T.-H. (J. Biol. Chem. 1999)
    8. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PubMed id 20805296)1, 4 Coulthard L.R....McDermott M.F. (Ann. Rheum. Dis. 2011)
    9. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    10. p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis. (PubMed id 20090411)1, 2 Efimova T. (Cell Cycle 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5603 HGNC: 6875 AceView: MAPK13 Ensembl:ENSG00000156711 euGenes: HUgn5603
    ECgene: MAPK13 Kegg: 5603 H-InvDB: MAPK13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPK13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK13 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPK13 gene:
    Search GeneIP for patents involving MAPK13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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