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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK13 Gene

protein-coding   GIFtS: 69
GCID: GC06P036095

mitogen-activated protein kinase 13


(Previous symbol: PRKM13)
 Explore 22 diseases affiliated with
MAPK13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAPK13    

Aliases
for MAPK13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase 131 2     MAP Kinase 132 3
PRKM131 2 3     MAP Kinase P38 Delta2 3
SAPK41 2 3     MAPK 132 3
P38delta1     EC 2.7.11.243 8
Mitogen-Activated Protein Kinase P38 Delta2 3     MAPK-132
Stress-Activated Protein Kinase 42 3     EC 2.7.118

External Ids:    HGNC: 68751   Entrez Gene: 56032   Ensembl: ENSG000001567117   OMIM: 6028995   UniProtKB: O152643   

Export aliases for MAPK13 gene to outside databases

Previous GC identifers: GC06P036100 GC06P036145 GC06P036129 GC06P035818


Summaries
for MAPK13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPK13:
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration
point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as
proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and
is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the
transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants
have been observed for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: MK13_HUMAN, O15264
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by
extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of
transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has
been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK
isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and
further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and
inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV
irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of
epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional
activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13
also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells

Gene Wiki entry for MAPK13


Genomic Views
for MAPK13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK13 gene promoter:
         SRF   SREBP-1c   SRF (504 AA)   Lmo2   STAT5A   AP-4   SREBP-1b   C/EBPalpha   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAPK13 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

MAPK13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK13 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036095:  view genomic region     (about GC identifiers)

Start:
 36,095,586 bp from pter      End:
 36,107,842 bp from pter
Size:
 12,257 bases      Orientation:
 plus strand

Proteins
for MAPK13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MK13_HUMAN, O15264 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 13  
Size: 365 amino acids; 42090 Da
Cofactor: Magnesium
Subunit: Interacts with MAPK8IP2
4 PDB 3D structures from and Proteopedia for MAPK13:
3COI (3D)        4EXU (3D)        4EYJ (3D)        4EYM (3D)    
Secondary accessions: O14739 O15124 Q6FI46 Q9UNU0

Explore the universe of human proteins at neXtProt for MAPK13: NX_O15264

Post-translational modifications:

  • Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates
    • the enzyme. Dephosphorylated by dual specificity phosphatase DUSP11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15264

    • 4/26 DME Specific Peptides for MAPK13 (O15264) (see all 26)
     ILDFGLA  VVHRDLK  LDFGLAR  LKYIHSA 

    MAPK13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002745.1  
    ENSEMBL proteins: 
     ENSP00000362866   ENSP00000211287   ENSP00000362864   ENSP00000362871  
    Reactome Protein details: O15264
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAPK13 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MAPK13
    OriGene Purified Protein: MAPK13
    OriGene Protein Over-expression Lysate: MAPK13
    OriGene Custom Protein Services for MAPK13 
    GenScript Custom Purified and Recombinant Proteins Services for MAPK13
    Novus Biologicals MAPK13 Proteins
    Novus Biologicals MAPK13 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MAPK13
    Uscn Proteins for MAPK13

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005829cytosol TAS--


    MAPK13 for ontologies           About GeneDecksing



    MAPK13 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK13
    R&D Systems Antibodies for MAPK13 (p38 delta)
    Cell Signaling Technology (CST) Antibodies for MAPK13  (p38-delta)
    OriGene Antibodies (see all 15): MAPK13
    OriGene Custom Antibody Services for MAPK13 
    GenScript Custom Superior Antibodies Services for MAPK13
    Novus Biologicals MAPK13 Antibodies
    Search for Antibodies for MAPK13 at Abcam  
    Uscn Antibodies for MAPK13
    ThermoFisher Antibodies for MAPK13

    Assay Products for MAPK13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for MAPK13 (p38 delta)         (see all)
    GenScript Custom Assay Services for MAPK13
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK13 (p38-delta)
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAPK13

    Protein Domains /
    Families
    for MAPK13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPK13 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O15264

    ProtoNet protein and cluster: O15264

    2 Blocks protein families:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK13_HUMAN, O15264
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAPK13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MK13_HUMAN, O15264
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
    MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by
    extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of
    transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has
    been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK
    isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and
    further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and
    inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV
    irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of
    epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional
    activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13
    also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on threonine and tyrosine by dual specificity kinases, MAP2K3/MKK3,
    MAP2K6/MKK6, MAP2K4/MKK4 and MAP2K7/MKK7. Activation by ultraviolet radiation, hyperosmotic shock, anisomycin or by
    TNF-alpha is mediated by MAP2K3/MKK3. Inhibited by dual specificity phosphatase DUSP1

    Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MAPK13
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK13
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK13:
    hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-1252 hsa-miR-3909 hsa-miR-449a hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK13 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK13 (see all 7)
    OriGene shRNA RFP: MAPK13
    OriGene siRNA: MAPK13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK13

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPK13

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK13 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAPK13 (NM_002754)
    Sino Biological Human cDNA Clone for MAPK13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK13 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAPK13
    Search LifeMap BioReagents cell lines for MAPK13

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK13

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15850461
    GO:0004707MAP kinase activity IDA9731215
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    MAPK13 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for MAPK13:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  G0/1 arrest  Increased G1 DNA content 
     Increased mitotic index  Wnt reporter downregulated 

    Animal Models:
         Mouse knock-outs for MAPK13: Mapk13tm1Lex Mapk13tm1Cnd Mapk13tm2.1Lex
         5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Mapk13):
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  no phenotypic analysis  normal 

    MAPK13 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPK13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/92 super-pathways (see all 92) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ErbB4 Pathway
    8/10 pathways (see all 10)
    		ErbB4 Pathway1.00
    		LPS Stimulated MAPK Signaling0.36
    		ErbB Family Pathway0.59
    		VEGF Signaling Pathway0.35
    		Prolactin Signaling0.54
    		TREM1 Pathway0.32
    		IL-2 Pathway0.46
    		HMGB1 Pathway0.32
    2G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    		G-protein signaling Ras family GTPases in kinase cascades (scheme)1.00
    		Immune response Oncostatin M signaling via MAPK in human cells0.39
    		G-protein signaling_Ras family GTPases in kinase cascades (scheme)1.00
    		Immune response_Role of integrins in NK cells cytotoxicity0.28
    		Immune response_Oncostatin M signaling via MAPK in human cells0.39
    		Immune response Role of integrins in NK cells cytotoxicity0.28
    34-1BB Pathway
    		4-1BB Pathway1.00
    		PKR Pathway0.36
    		CD40 Signaling0.54
    		NF-KappaB Activation by EBV0.31
    		CMV and MAPK Pathways0.38
    		SUMO Pathway0.30
    4Toll Comparative Pathway
    		Toll Comparative Pathway1.00
    		Immune response MIF in innate immunity response0.46
    		TLR-TRIF Pathway0.61
    		IL-1 Pathway0.39
    		Immune response_MIF in innate immunity response0.46
    		iNOS Signaling0.34
    5GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/22 EMD Millipore Pathways for MAPK13 (see all 22)
        Development A1 receptor signaling
    Immune response MIF in innate immunity response
    G-protein signaling G-Protein alpha-12 signaling pathway
    Development TGF-beta receptor signaling
    Immune response CCR3 signaling in eosinophils

    3 R&D Systems Pathways for MAPK13
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways
    TGF-beta Signaling Pathways

    5/89 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK13 (see all 89)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK13
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK13
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    5/24 GeneGo (Thomson Reuters) Pathways for MAPK13 (see all 24)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway

    5 BioSystems Pathways for MAPK13 
        MAPK signaling pathway
    Parkinsons Disease Pathway
    Insulin Signaling
    Toll-like receptor signaling pathway
    Signaling mediated by p38-gamma and p38-delta

    5/14        Reactome Pathways for MAPK13 (see all 14)
        Signalling to RAS
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    DSCAM interactions
    NGF signalling via TRKA from the plasma membrane
    p38MAPK events

    1 PharmGKB Pathway for MAPK13
        VEGF Signaling Pathway

    5/22         Kegg Pathways  (Kegg details for MAPK13) (see all 22):
        MAPK signaling pathway
    VEGF signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway


    MAPK13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/194 Interacting proteins for MAPK13 (O152641, 2, 3 ENSP000002112874) via UniProtKB, MINT, STRING, and/or I2D (see all 194)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKD1Q151391, 3EBI-2116951,EBI-1181072 I2D: score=1 
    SMAD4Q134852, 3, ENSP000003415514MINT-61974 I2D: score=3 STRING: ENSP00000341551
    MAPKAPK5Q8IW413, ENSP000002027884I2D: score=3 STRING: ENSP00000202788
    AKIP1Q9NQ313, ENSP000003104594I2D: score=2 STRING: ENSP00000310459
    ANKLE2Q86XL33, ENSP000003506864I2D: score=2 STRING: ENSP00000350686
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IDA9731215
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation ----
    GO:0006950response to stress IDA9218798


    MAPK13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPK13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK13 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK13:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAPK13

    3 HMDB Compounds for MAPK13    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    6 Novoseek chemical compound relationships for MAPK13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyridinylimidazole 88.2 1 9374491 (1)
    sb 203580 54.2 2 17481747 (1), 17256148 (1)
    12-o-tetradecanoylphorbol 13-acetate 41.2 2 19458068 (1)
    okadaic acid 32.8 2 17256148 (2)
    serine 17.1 1 9199504 (1)
    atp 0 1 9624152 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK13 / MK13 

    Transcripts
    for MAPK13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPK13 gene: 
    NM_002754.4  

    Unigene Cluster for MAPK13:

    Mitogen-activated protein kinase 13
    Hs.178695  [show with all ESTs]
    Unigene Representative Sequence: NM_002754
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476951 ENST00000373761 ENST00000211287(uc003ols.3 uc003olt.3)
    ENST00000373759 ENST00000490334 ENST00000373766

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MAPK13
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK13
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK13:
    hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-1252 hsa-miR-3909 hsa-miR-449a hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK13 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK13 (see all 7)
    OriGene shRNA RFP: MAPK13
    OriGene siRNA: MAPK13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK13
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK13 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK13 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAPK13 (NM_002754)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK13 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAPK13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPK13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK13

    Additional cDNA sequence: 

    AB451221.1 AB451344.1 AF004709.1 AF015256.1 AF092535.1 AF100546.1 AK222922.1 AK308018.1 
    BC000433.2 BC001641.2 BC004428.1 BC085196.1 BT007221.1 CR536490.1 CR541687.1 NR_072996.1 
    U93232.1 Y10488.1 

    13 DOTS entries:

    DT.75139262  DT.97838957  DT.121396393  DT.75184240  DT.100022242  DT.99970880  DT.100816810  DT.100816808 
    DT.75143119  DT.92030945  DT.92427717  DT.100816806  DT.97843903 

    24/132 AceView cDNA sequences (see all 132):

    BM981671 CR536490 BM726228 AA297419 BG740841 Y10488 AA548684 AA860797 
    AA788736 BG290544 CR603684 BU682484 BX460545 CB217130 AW366972 AI050988 
    BT007221 BM973431 AA568285 BM680925 AF100546 CR595896 AW366945 U93232 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK13 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14
    SP1:                          -     -                                                                       -                                 
    SP2:                          -     -                                         -     -     -                 -                                 
    SP3:                          -     -                                               -     -     -           -                                 
    SP4:                                                                          -     -     -                 -                                 
    SP5:                          -     -                                         -     -     -                                                   


    ECgene alternative splicing isoforms for MAPK13

    Expression
    for MAPK13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCACCGCCGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPK13 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal Collecting Duct SystemKidney
    KidneyRenal VesicleKidney
    TestisSeminiferous TubulesTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAPK13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK13

    SOURCE GeneReport for Unigene cluster: Hs.178695

    UniProtKB/Swiss-Prot: MK13_HUMAN, O15264
    Tissue specificity: Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also
    present in neutrophils, CD4+ T-cells, and endothelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK13: 
              Cytoskeleton Regulators in human mouse rat
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for MAPK13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK13 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAPK131 mitogen-activated protein kinase 13 76.26(n)
    79.45(a)    		   771145  XM_001234442.1  XP_001234443.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPK136
    		 --
    		 79(a)
    		 1 ↔ 1
    		 GL343382.1(592879-628017)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.30652 Transcribed sequence with weak similarity to protein more 74.32(n)    BX742715.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mapk131 mitogen-activated protein kinase 13 65.73(n)
    66.76(a)    		   100002318  XM_001337797.4  XP_001337833.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta p38b3 regulation of BMP signaling pathway protein
    serine/threonine more    		 58(a)
    (best of 3)    		   34D1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea pmk-13 ser/thr kinases 56(a)
    (best of 6)    		   IV(8148976-8149980)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATMPK46
    MPK116
    (see all 20)    		 mitogen-activated protein kinase 11
    (see all 20)    		 42(a)
    42(a)
    (see all 20)    		 many ↔ many
    many ↔ many
    (see all 20)    		 4(567095-569088)
    1(202136-204335)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 16)    		 CGMC_MAPKCMGC_2_SLT2y_ERK.2 - CGMC includes CDA, M...
    CGMC_MAPKCMGC_2_SLT2y_ERK.1 - CGMC includes CDA, M...
    (see all 16)    		 42(a)
    41(a)
    (see all 16)    		 many ↔ many
    many ↔ many
    (see all 16)    		 6(29397209-29401633)
    2(2642975-2646358)


    ENSEMBL Gene Tree for MAPK13 (if available)
    TreeFam Gene Tree for MAPK13 (if available) 

    Paralogs
    for MAPK13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK13 gene
    MAPK92  MAPK122  MAPK112  MAPK142  MAPK102  MAPK82  
    18/61 SIMAP similar genes for MAPK13 using alignment to 6 protein entries:     MK13_HUMAN (see all proteins) (see all similar genes):
    MAPK14    MAPK12    DKFZp686M02159    MAPK11    MAPK10    MAPK8
    DKFZp686O0215    MAPK9    MAPK3    MAPK7    MAPK1    NLK
    MAPK4    MAPK15    DKFZp434M058    MAPK6    CDKL2    CDK11A

    MAPK13 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPK13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/292 NCBI SNPs in MAPK13 are shown (see all 292)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1390215291,2
    		--36096269(+) AATGAA/CGGGCA 2 -- us2k10--------
    rs1156752621,2
    		F,--36096338(+) CATTCA/TTTCTC 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs28158091,2
    		C,F,A,H,--36096357(+) TGCTGA/TTATAT 2 -- us2k123Minor allele frequency- T:0.15NS EA NA WA CSA 2339
    rs1427404451,2
    		C,--36096437(+) TGGCA-/CCCCAC 2 -- us2k10--------
    rs37619771,2
    		C,F,A,H,--36096447(-) TGAGAT/AGAGGG 2 -- us2k111Minor allele frequency- A:0.32EA NS NA CSA WA 2444
    rs28591421,2
    		C,F,A,--36096543(-) GGGGGT/CCCACA 2 -- us2k111Minor allele frequency- C:0.29NA WA CSA EA 372
    rs1416002961,2
    		--36096544(+) GTGGGC/TCCCCG 2 -- us2k10--------
    rs77706961,2
    		C,F,--36096646(+) CCCCAT/CGCCTG 2 -- us2k15Minor allele frequency- C:0.23WA CSA 126
    rs1825298351,2
    		--36096738(+) CCTCAC/GAGGCC 2 -- us2k10--------
    rs64578801,2
    		C,F,H,--36096759(+) GAGCAT/AAGAAT 2 -- us2k124Minor allele frequency- A:0.07NS EA NA WA CSA 2229

    HapMap Linkage Disequilibrium report for MAPK13 (36095586 - 36107842 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAPK13: --

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    Disorders / Diseases
    for MAPK13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPK13 for disorders           About GeneDecksing

    OMIM gene information: 602899    OMIM disorders: --

    20/22 diseases for MAPK13 (see all 22):    About MalaCards
    amyotrophic lateral sclerosis (als)    amyotrophic lateral sclerosis    lateral sclerosis    chagas disease
    shigellosis    rheumatoid arthritis    hepatitis c    trypanosomiasis
    toxoplasmosis    leishmaniasis    pertussis    neurodegeneration
    arthritis    influenza    hepatitis    hypoxia
    tuberculosis    immunodeficiency    pancreatitis    malaria

    2 Novoseek disease relationships for MAPK13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 23 2 17482683 (1), 14694199 (1)
    tumors 0 2 17334397 (1), 19458068 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAPK13 (6 documents)

    Export disorders for MAPK13 gene to outside databases

    Publications
    for MAPK13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK13 gene, integrated from 9 sources (see all 91):
    (articles sorted by number of sources associating them with MAPK13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PubMed id 9218798)1, 2, 3, 9 Goedert M.... Cohen P. (1997)
    2. Molecular cloning and characterization of a novel p38 mitogen- activated protein kinase. (PubMed id 9295308)1, 2, 3, 9 Wang X.S.... Yao Z. (1997)
    3. Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4. (PubMed id 10727080)1, 2, 9 Herbison C.E.... Price P. (1999)
    4. MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta. (PubMed id 18367666)1, 2, 9 Zhou X....Burg M.B. (2008)
    5. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. (PubMed id 9374491)1, 2, 9 Jiang Y.... Han J. (1997)
    6. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. (PubMed id 10201954)1, 2, 9 Hale K.K.... Manthey C.L. (1999)
    7. Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. (PubMed id 10066767)1, 2, 9 Hu M.C.-T.... Tan T.-H. (1999)
    8. p38delta mitogen-activated protein kinase regulates s kin homeostasis and tumorigenesis. (PubMed id 20090411)1, 2 Efimova T. (2010)
    9. Human p38 delta MAP kinase mediates UV irradiation in duced up-regulation of the gene expression of chemokine BRAK/CXCL14. (PubMed id 20478268)1, 2 Ozawa S....Hata R. (2010)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for MAPK13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAPK13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5603 HGNC: 6875 AceView: MAPK13 Ensembl:ENSG00000156711 euGenes: HUgn5603
    ECgene: MAPK13 Kegg: 5603 H-InvDB: MAPK13

    Other Databases showing MAPK13 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAPK13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK13 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAPK13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPK13 gene:
    Search GeneIP for patents involving MAPK13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MAPK13 gene

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    About This Section

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