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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK13 Gene

protein-coding   GIFtS: 72
GCID: GC06P036095

Mitogen-Activated Protein Kinase 13


(Previous symbol: PRKM13)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase 131 2     MAP Kinase P38 Delta2 3
PRKM131 2 3     MAPK 132 3
Mitogen-Activated Protein Kinase P38 Delta2 3     EC 2.7.11.243 8
Stress-Activated Protein Kinase 42 3     MAPK-132
SAPK42 3     p38delta2
MAP Kinase 132 3     EC 2.7.118

External Ids:    HGNC: 68751   Entrez Gene: 56032   Ensembl: ENSG000001567117   OMIM: 6028995   UniProtKB: O152643   

Export aliases for MAPK13 gene to outside databases

Previous GC identifers: GC06P036100 GC06P036145 GC06P036129 GC06P035818


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPK13 Gene:
This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration
point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as
proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase
and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the
transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript
variants have been observed for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for MAPK13 Gene: 
MAPK13 (mitogen-activated protein kinase 13) is a protein-coding gene. Diseases associated with MAPK13 include trypanosomiasis, and shigellosis, and among its related super-pathways are Development FGF-family signaling and TLR-TRIF Pathway. GO annotations related to this gene include MAP kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is MAPK9.

UniProtKB/Swiss-Prot: MK13_HUMAN, O15264
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins
and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less
studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated
through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein
translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through
phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of
CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin
tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid
MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during
regulation of insulin secretion in pancreatic beta cells

Gene Wiki entry for MAPK13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK13 gene promoter:
         SRF   SREBP-1c   SRF (504 AA)   Lmo2   STAT5A   AP-4   SREBP-1b   C/EBPalpha   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAPK13 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

MAPK13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK13 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036095:  view genomic region     (about GC identifiers)

Start:
36,095,586 bp from pter      End:
36,107,842 bp from pter
Size:
12,257 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MK13_HUMAN, O15264 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 13  
Size: 365 amino acids; 42090 Da
Cofactor: Magnesium
Subunit: Interacts with MAPK8IP2
4 PDB 3D structures from and Proteopedia for MAPK13:
3COI (3D)        4EXU (3D)        4EYJ (3D)        4EYM (3D)    
Secondary accessions: O14739 O15124 Q6FI46 Q9UNU0

Explore the universe of human proteins at neXtProt for MAPK13: NX_O15264

Explore proteomics data for MAPK13 at MOPED 

Post-translational modifications:

  • UniProtKB: Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which
    activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15264

  • 4/26 DME Specific Peptides for MAPK13 (O15264) (see all 26)
     ILDFGLA  VVHRDLK  LDFGLAR  LKYIHSA 

    MAPK13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAPK13 Protein Expression
    REFSEQ proteins: NP_002745.1  
    ENSEMBL proteins: 
     ENSP00000211287   ENSP00000362864   ENSP00000362866   ENSP00000362871  
    Reactome Protein details: O15264
    Human Recombinant Protein Products for MAPK13: 
    EMD Millipore Purified and/or Recombinant MAPK13 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MAPK13
    OriGene Purified Protein for MAPK13
    OriGene Protein Over-expression Lysate for MAPK13
    OriGene MassSpec for MAPK13 
    OriGene Custom Protein Services for MAPK13
    GenScript Custom Purified and Recombinant Proteins Services for MAPK13
    Novus Biologicals MAPK13 Proteins
    Novus Biologicals MAPK13 Lysates
    Sino Biological Recombinant Protein for MAPK13
    Sino Biological Cell Lysate for MAPK13 
    ProSpec Recombinant Protein for MAPK13
    Cloud-Clone Corp. Proteins for MAPK13 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    MAPK13 for ontologies           About GeneDecksing



    MAPK13 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK13
    R&D Systems Antibodies for MAPK13 (p38 delta)
    Cell Signaling Technology (CST) Antibodies for MAPK13  (P38D)
    OriGene Antibodies for MAPK13
    OriGene Custom Antibody Services for MAPK13
    GenScript Custom Superior Antibodies Services for MAPK13
    Novus Biologicals MAPK13 Antibodies
    Abcam antibodies for MAPK13
    Cloud-Clone Corp. Antibodies for MAPK13 
    ThermoFisher Antibodies for MAPK13
    LSBio Antibodies in human, mouse, rat for MAPK13 

    Assay Products for MAPK13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAPK13
    R&D Systems ELISAs for MAPK13 (p38 delta)         (see all)
    GenScript Custom Assay Services for MAPK13
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK13 (P38D)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK13 
    Cloud-Clone Corp. CLIAs for MAPK13


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 13 
    p38 subfamily
    Mitogen-activated protein kinases

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O15264

    ProtoNet protein and cluster: O15264

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK13_HUMAN, O15264
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK13_HUMAN, O15264
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
    evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
    of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins
    and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less
    studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated
    through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein
    translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through
    phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of
    CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin
    tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid
    MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during
    regulation of insulin secretion in pancreatic beta cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on threonine and tyrosine by dual specificity kinases,
    MAP2K3/MKK3, MAP2K6/MKK6, MAP2K4/MKK4 and MAP2K7/MKK7. Activation by ultraviolet radiation, hyperosmotic shock,
    anisomycin or by TNF-alpha is mediated by MAP2K3/MKK3. Inhibited by dual specificity phosphatase DUSP1

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA12244047
    GO:0004707MAP kinase activity IDA9218798
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI19135240
         
    MAPK13 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for MAPK13:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  G0/1 arrest  Increased G1 DNA content 
     Increased mitotic index  Wnt reporter downregulated 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Mapk13):
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  no phenotypic analysis  normal 

    MAPK13 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAPK13: Mapk13tm1Lex Mapk13tm1Cnd Mapk13tm2.1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAPK13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAPK13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK13 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK13 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK13
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK13:
    hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-1252 hsa-miR-3909 hsa-miR-449a hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmidMAPK13 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAPK13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK13
    Sirion Biotech Customized adenovirus for overexpression of MAPK13

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAPK13 (see all 8)
    OriGene ORF clones in mouse, rat for MAPK13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK13 (NM_002754)
    Sino Biological Human cDNA Clone for MAPK13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK13
    Sirion Biotech Customized lentivirus for stable overexpression of MAPK13 
                         Customized lentivirus expression plasmids for stable overexpression of MAPK13 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK13
    Search LifeMap BioReagents cell lines for MAPK13
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAPK13 About   (see all 103)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development FGF-family signaling
    Development FGF-family signaling0.63
    Development Flt3 signaling0.45
    Development FGFR signaling pathway0.50
    FGF Pathway0.38
    2Toll Comparative Pathway
    Toll Comparative Pathway0.61
    IL-1 Pathway0.39
    TLR-TRIF Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    3Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.69
    4Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    VEGF signaling pathway0.39
    Fc epsilon RI signaling pathway0.40
    5Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Chagas disease (American trypanosomiasis)0.33
    Toll-like receptor signaling pathway0.93

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/22 EMD Millipore Pathways for MAPK13 (see all 22)
        Development A1 receptor signaling
    Immune response MIF in innate immunity response
    G-protein signaling G-Protein alpha-12 signaling pathway
    Development TGF-beta receptor signaling
    Immune response CCR3 signaling in eosinophils

    5/7 R&D Systems Pathways for MAPK13 (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/89 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK13 (see all 89)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK13
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK13
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    5/24 GeneGo (Thomson Reuters) Pathways for MAPK13 (see all 24)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway

    5 BioSystems Pathways for MAPK13
        MAPK signaling pathway
    Insulin Signaling
    Parkinsons Disease Pathway
    Toll-like receptor signaling pathway
    Signaling mediated by p38-gamma and p38-delta

    4 Sino Biological Pathways for MAPK13 
        Non-Canonical Wnt Pathway
    p53 Pathway
    VEGF Signaling
    TGF-beta Signaling Pathway

    5/12        Reactome Pathways for MAPK13 (see all 12)
        Signalling to RAS
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    DSCAM interactions
    NGF signalling via TRKA from the plasma membrane
    p38MAPK events

    1 PharmGKB Pathway for MAPK13
        VEGF Signaling Pathway

    5/29         Kegg Pathways  (Kegg details for MAPK13) (see all 29):
        MAPK signaling pathway
    VEGF signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway


    MAPK13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/195 Interacting proteins for MAPK13 (O152641, 2, 3 ENSP000002112874) via UniProtKB, MINT, STRING, and/or I2D (see all 195)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKD1Q151391, 3EBI-2116951,EBI-1181072 I2D: score=1 
    SMAD4Q134852, 3, ENSP000003415514MINT-61974 I2D: score=3 STRING: ENSP00000341551
    ANKLE2Q86XL33, ENSP000003506864I2D: score=2 STRING: ENSP00000350686
    MAP3K4Q9Y6R43, ENSP000003759864I2D: score=2 STRING: ENSP00000375986
    EEF2P136393, ENSP000003079404I2D: score=1 STRING: ENSP00000307940
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IDA9218798
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation ----
    GO:0006950response to stress IDA9218798

    MAPK13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK13 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK13:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAPK13 (MK13)

    3 HMDB Compounds for MAPK13    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    6 Novoseek inferred chemical compound relationships for MAPK13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyridinylimidazole 88.2 1 9374491 (1)
    sb 203580 54.2 2 17481747 (1), 17256148 (1)
    12-o-tetradecanoylphorbol 13-acetate 41.2 2 19458068 (1)
    okadaic acid 32.8 2 17256148 (2)
    serine 17.1 1 9199504 (1)
    atp 0 1 9624152 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK13 / MK13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAPK13 gene: 
    NM_002754.4  

    Unigene Cluster for MAPK13:

    Mitogen-activated protein kinase 13
    Hs.178695  [show with all ESTs]
    Unigene Representative Sequence: NM_002754
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476951 ENST00000211287(uc003ols.3 uc003olt.3) ENST00000373759
    ENST00000490334 ENST00000373761 ENST00000373766

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK13
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK13:
    hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-1252 hsa-miR-3909 hsa-miR-449a hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmidMAPK13 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAPK13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK13
    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK13 (see all 8)
    OriGene ORF clones in mouse, rat for MAPK13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK13 (NM_002754)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK13
    Sirion Biotech Customized lentivirus for stable overexpression of MAPK13 
                         Customized lentivirus expression plasmids for stable overexpression of MAPK13 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAPK13
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK13
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAPK13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAPK13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAPK13

    Additional mRNA sequence: 

    AB451221.1 AB451344.1 AF004709.1 AF015256.1 AF092535.1 AF100546.1 AK222922.1 AK308018.1 
    BC000433.2 BC001641.2 BC004428.1 BC085196.1 BT007221.1 CR536490.1 CR541687.1 NR_072996.1 
    U93232.1 Y10488.1 

    13 DOTS entries:

    DT.75139262  DT.97838957  DT.121396393  DT.75184240  DT.100022242  DT.99970880  DT.100816810  DT.100816808 
    DT.75143119  DT.92030945  DT.92427717  DT.100816806  DT.97843903 

    24/132 AceView cDNA sequences (see all 132):

    AF100546 AA568285 BM726228 CR536490 AA548684 CR603684 BM973431 AW366945 
    BT007221 BG740841 AA297419 AA860797 AI050988 Y10488 BU682484 AA788736 
    BX460545 AW366972 CB217130 CR595896 BM981671 BM680925 BG290544 CA307003 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK13 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14
    SP1:                          -     -                                                                       -                                 
    SP2:                          -     -                                         -     -     -                 -                                 
    SP3:                          -     -                                               -     -     -           -                                 
    SP4:                                                                          -     -     -                 -                                 
    SP5:                          -     -                                         -     -     -                                                   


    ECgene alternative splicing isoforms for MAPK13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK13 expression in normal human tissues (normalized intensities)      MAPK13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCGCCGG
    MAPK13 Expression
    About this image


    MAPK13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Esophagus (Gastrointestinal Tract)
             esophageal epithelium   
     
     Colon (Gastrointestinal Tract)
             colonic mucosal (ibs)   
     
     Testis (Reproductive System)
             Seminiferous Tubules

    See MAPK13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK13

    SOURCE GeneReport for Unigene cluster: Hs.178695

    UniProtKB/Swiss-Prot: MK13_HUMAN, O15264
    Tissue specificity: Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also
    present in neutrophils, CD4+ T-cells, and endothelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK13: 
              Cytoskeleton Regulators in human mouse rat
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MAPK13 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk131 , 5 mitogen-activated protein kinase 131, 5 88.13(n)1
    93.15(a)1
      17 (15.00 cM)5
    264151  NM_011950.21  NP_036080.21 
     287693075 
    chicken
    (Gallus gallus)
    Aves MAPK131 mitogen-activated protein kinase 13 76.26(n)
    79.45(a)
      771145  XM_001234442.1  XP_001234443.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK136
    Uncharacterized protein
    79(a)
    1 ↔ 1
    GL343382.1(590045-628318)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.30652 Transcribed sequence with weak similarity to protein more 74.32(n)    BX742715.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapk131 mitogen-activated protein kinase 13 65.73(n)
    66.76(a)
      100002318  XM_001337797.4  XP_001337833.2 


    ENSEMBL Gene Tree for MAPK13 (if available)
    TreeFam Gene Tree for MAPK13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK13 gene
    MAPK92  MAPK122  MAPK112  MAPK142  MAPK82  MAPK102  
    18/62 SIMAP similar genes for MAPK13 using alignment to 6 protein entries:     MK13_HUMAN (see all proteins) (see all similar genes):
    MAPK14    MAPK12    DKFZp686M02159    MAPK11    MAPK10    MAPK8
    DKFZp686O0215    MAPK9    MAPK3    MAPK7    MAPK1    NLK
    MAPK4    MAPK15    DKFZp434M058    MAPK6    CDKL2    CDK11A

    MAPK13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/393 SNPs in MAPK13 are shown (see all 393)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs667084171,2
    C--36017011(+) TCTCA-/A/AA  
            
    AAAAA
    2 -- int11NA 2
    rs1390215291,2
    --36096269(+) AATGAA/CGGGCA 2 -- us2k10--------
    rs1156752621,2
    F--36096338(+) CATTCA/TTTCTC 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs28158091,2
    C,F,A,H--36096357(+) TGCTGA/TTATAT 2 -- us2k123Minor allele frequency- T:0.15NS EA NA WA CSA 2339
    rs1427404451,2
    C--36096437(+) TGGCA-/CCCCAC 2 -- us2k10--------
    rs37619771,2
    C,F,A,H--36096447(-) TGAGAT/AGAGGG 2 -- us2k111Minor allele frequency- A:0.32EA NS NA CSA WA 2444
    rs28591421,2
    C,F,A--36096543(-) GGGGGT/CCCACA 2 -- us2k111Minor allele frequency- C:0.29NA WA CSA EA 372
    rs1416002961,2
    --36096544(+) GTGGGC/TCCCCG 2 -- us2k10--------
    rs77706961,2
    C,F--36096646(+) CCCCAT/CGCCTG 2 -- us2k15Minor allele frequency- C:0.23WA CSA 126
    rs1825298351,2
    --36096738(+) CCTCAC/GAGGCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAPK13 (36095586 - 36107842 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAPK13: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK13
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602899    OMIM disorders: --

    19 diseases for MAPK13:    About MalaCards
    trypanosomiasis    shigellosis    chagas disease    toxoplasmosis
    lateral sclerosis    amyotrophic lateral sclerosis    pertussis    leishmaniasis
    influenza    hepatitis c    hypoxia    rheumatoid arthritis
    arthritis    parkinson's disease    endotheliitis    tuberculosis
    hepatitis    pancreatitis    breast cancer


    MAPK13 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for MAPK13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 23 2 17482683 (1), 14694199 (1)
    tumors 0 2 17334397 (1), 19458068 (1)

    Genetic Association Database (GAD): MAPK13
    Human Genome Epidemiology (HuGE) Navigator: MAPK13 (6 documents)

    Export disorders for MAPK13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK13 gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with MAPK13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PubMed id 9218798)1, 2, 3, 9 Goedert M.... Cohen P. (1997)
    2. Molecular cloning and characterization of a novel p38 mitogen- activated protein kinase. (PubMed id 9295308)1, 2, 3, 9 Wang X.S.... Yao Z. (1997)
    3. Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4. (PubMed id 10727080)1, 2, 9 Herbison C.E.... Price P. (1999)
    4. MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta. (PubMed id 18367666)1, 2, 9 Zhou X....Burg M.B. (2008)
    5. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. (PubMed id 9374491)1, 2, 9 Jiang Y.... Han J. (1997)
    6. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. (PubMed id 10201954)1, 2, 9 Hale K.K.... Manthey C.L. (1999)
    7. Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. (PubMed id 10066767)1, 2, 9 Hu M.C.-T.... Tan T.-H. (1999)
    8. Genetic variants within the MAP kinase signalling net work and anti-TNF treatment response in rheumatoid arthritis patients. (PubMed id 20805296)1, 4 Coulthard L.R....McDermott M.F. (2011)
    9. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    10. p38delta mitogen-activated protein kinase regulates s kin homeostasis and tumorigenesis. (PubMed id 20090411)1, 2 Efimova T. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5603 HGNC: 6875 AceView: MAPK13 Ensembl:ENSG00000156711 euGenes: HUgn5603
    ECgene: MAPK13 Kegg: 5603 H-InvDB: MAPK13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK13 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAPK13 gene:
    Search GeneIP for patents involving MAPK13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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