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MAPK12 Gene

protein-coding   GIFtS: 74
GCID: GC22M050684

Mitogen-Activated Protein Kinase 12


(Previous symbol: SAPK3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 121 2     MAPK 122 3
SAPK31 2 3 5     EC 2.7.11.243 8
Extracellular Signal-Regulated Kinase 62 3     ERK32 5
Mitogen-Activated Protein Kinase P38 Gamma2 3     P38GAMMA2
Stress-Activated Protein Kinase 32 3     PRKM122
ERK-62 3     SAPK-32
ERK62 3     Mitogen-Activated Protein Kinase 32
MAP Kinase 122 3     EC 2.7.118
MAP Kinase P38 Gamma2 3     

External Ids:    HGNC: 68741   Entrez Gene: 63002   Ensembl: ENSG000001881307   OMIM: 6023995   UniProtKB: P537783   

Export aliases for MAPK12 gene to outside databases

Previous GC identifers: GC22M047242 GC22M048873 GC22M048993 GC22M049033


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK12 Gene:
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of
extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by
this gene functions as a signal transducer during differentiation of myoblasts to myotubes. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MAPK12 Gene:
MAPK12 (mitogen-activated protein kinase 12) is a protein-coding gene. GO annotations related to this gene include MAP kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is MAPK9.

UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins
and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are
downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate
additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in
response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting
differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its
association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent
of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to
osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA
damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression
and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated
glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by
MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of
PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively
regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration

Gene Wiki entry for MAPK12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011526.8  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK12 gene promoter:
         CRE-BP1   p53   STAT3   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPK12 promoter sequence
   Search Chromatin IP Primers for MAPK12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.3

MAPK12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK12 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050684:  view genomic region     (about GC identifiers)

Start:
50,683,879 bp from pter      End:
50,700,254 bp from pter
Size:
16,376 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MK12_HUMAN, P53778 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 12  
Size: 367 amino acids; 41940 Da
Cofactor: Binds 2 magnesium ions
Subunit: Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5. Interacts with
LIN7C, SCRIB and SYNJ2BP (By similarity)
1 PDB 3D structure from and Proteopedia for MAPK12:
1CM8 (3D)    
Secondary accessions: Q14260 Q99588 Q99672

Explore the universe of human proteins at neXtProt for MAPK12: NX_P53778

Explore proteomics data for MAPK12 at MOPED

Post-translational modifications: 

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K3/MKK3 and MAP2K6/MKK6, which activates the enzyme1
  • Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPK12 (P53778) (see all 16)
     ILDFGLA  LDFGLAR  LLDVFTP  VGSGAYG 


    See MAPK12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002960.2  
    ENSEMBL proteins: 
     ENSP00000379126   ENSP00000215659   ENSP00000379124  
    Reactome Protein details: P53778

    MAPK12 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MAPK12
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAPK12
    GenScript Custom Purified and Recombinant Proteins Services for MAPK12
    Novus Biologicals MAPK12 Proteins
    Novus Biologicals MAPK12 Lysates
    Sino Biological Recombinant Protein for MAPK12
    Sino Biological Cell Lysate for MAPK12
    ProSpec Recombinant Protein for MAPK12
    Cloud-Clone Corp. Proteins for MAPK12

     
    Search eBioscience for Proteins for MAPK12 

     
    antibodies-online proteins for MAPK12 (5 products) 

     
    antibodies-online peptides for MAPK12

    MAPK12 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK12
    R&D Systems Antibodies for MAPK12 (p38 gamma)
    Cell Signaling Technology (CST) Antibodies for MAPK12  (P38G)
    OriGene Antibodies for MAPK12
    OriGene Custom Antibody Services for MAPK12
    Novus Biologicals MAPK12 Antibodies
    Abcam antibodies for MAPK12
    Cloud-Clone Corp. Antibodies for MAPK12
    ThermoFisher Antibody for MAPK12
    antibodies-online antibodies for MAPK12 (91 products) 

    MAPK12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAPK12
    R&D Systems ELISAs for MAPK12 (p38 gamma)         (see all)
    GenScript Custom Assay Services for MAPK12
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK12 (P38G)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK12
    Cloud-Clone Corp. CLIAs for MAPK12
    Search eBioscience for ELISAs for MAPK12 
    antibodies-online kits for MAPK12 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 12
    p38 subfamily
    Mitogen-activated protein kinases

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P53778

    ProtoNet protein and cluster: P53778

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAPK12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK12_HUMAN, P53778
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
    evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
    of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins
    and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are
    downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate
    additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in
    response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting
    differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its
    association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent
    of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to
    osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA
    damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression
    and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated
    glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by
    MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of
    PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively
    regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on threonine and tyrosine. MAP2K3/MKK3 and MAP2K6/MKK6 are both
    essential for the activation of MAPK12 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK12
    activator in response to TNF-alpha
    Biophysicochemical properties: Kinetic parameters: KM=37 uM for ATP; KM=313 uM for EGFR substrate peptide; KM=254
    uM for GST-ATF2;
    Induction: Expression of MAPK12 is down-regulation by MAPK14 activation

         Genatlas biochemistry entry for MAPK12:
    mitogen-activated protein kinase 12

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA10508788
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15850461
    GO:0004707MAP kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with MAPK12           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAPK12:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Gemcitabine induced cell-death  Increased cell death HMECs cel 
     PARP inhibitor sensitization 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mapk12):
     cardiovascular system  cellular  muscle  normal 

    Find genes that share phenotypes with MAPK12           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MAPK12: Mapk12tm1.1Lex Mapk12tm1Cnd

       genOway: Develop your customized and physiologically relevant rodent model for MAPK12

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MAPK12 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate MAPK12:
    hsa-miR-125a-5p hsa-miR-1283 hsa-miR-670 hsa-miR-125b hsa-miR-198 hsa-miR-4268 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidMAPK12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPK12
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK12

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK12 (see all 8)
    OriGene ORF clones in mouse, rat for MAPK12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK12 (NM_002969)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK12
    Addgene plasmids for MAPK12 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MK12_HUMAN, P53778: Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In
    skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with MAPK12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK12 About   (see all 111)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Fc epsilon RI signaling pathway0.41
    VEGF - VEGF R2 Signaling Pathways0.35
    2Toll Comparative Pathway
    Toll Comparative Pathway0.61
    IL-1 Pathway0.39
    TLR-TRIF Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    4Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.68
    5G protein signaling Ras family GTPases in kinase cascades scheme
    G protein signaling Ras family GTPases in kinase cascades scheme 0.44
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    MAPK Cascade0.44


    Find genes that share SuperPaths with MAPK12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for MAPK12 (see all 8)
        Inflammasome Activation Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK12 (see all 104)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPK12
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK12
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MAPK12 (see all 24)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway

    Selected BioSystems Pathways for MAPK12 (see all 11)
        MAPK signaling pathway
    Focal Adhesion
    Integrin-mediated cell adhesion
    Signal Transduction of S1P Receptor
    Insulin Signaling

    2 Sino Biological Pathways for MAPK12
        Notch Signaling Pathway
    TGF-beta Signaling Pathway

    5 Reactome Pathways for MAPK12
        p38MAPK events
    Activation of PPARGC1A (PGC-1alpha) by phosphorylation
    NOD1/2 Signaling Pathway
    CDO in myogenesis
    DSCAM interactions

    1 PharmGKB Pathway for MAPK12
        VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for MAPK12) (see all 34):
        MAPK signaling pathway
    Rap1 signaling pathway
    FoxO signaling pathway
    Oocyte meiosis
    Adrenergic signaling in cardiomyocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK12: 
              DNA Damage Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK12 (P537781, 2, 3 ENSP000002156594) via UniProtKB, MINT, STRING, and/or I2D (see all 167)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PKN1Q165121, 3, ENSP000003433254EBI-602406,EBI-602382 I2D: score=2 STRING: ENSP00000343325
    SNTA1Q134242, 3, ENSP000002173814MINT-59511 I2D: score=3 STRING: ENSP00000217381
    DLG3Q927963, ENSP000003634804I2D: score=1 STRING: ENSP00000363480
    DUSP1P285623, ENSP000002392234I2D: score=1 STRING: ENSP00000239223
    EEF2KO004183, ENSP000002630264I2D: score=1 STRING: ENSP00000263026
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006468protein phosphorylation ----
    GO:0006975DNA damage induced protein phosphorylation TAS10848581

    Find genes that share ontologies with MAPK12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    10 ApexBio Compounds for MAPK12     About this table
    CompoundAction CAS #
    BIRB 796 (Doramapimod)Cell pemeable p38 MAP Kinase Inhibitor [285983-48-4]
    LY2228820Potent and ATP-competitive p38 MAP kinase inhibitor[862507-23-1]
    PD 169316p38 MAPK inhibitor[152121-53-4]
    PH-797804Potent and selective p38 MAP kinase inhibitor[586379-66-0]
    SB 203580Cell permeable, reversible, and ATP-competitive p38 MAP kinase inhibitor[152121-47-6]
    SB202190 (FHPI)highly selective, potent and cell-permeable inhibitor of p38 MAP kinase[152121-30-7]
    Skepinone-Lselective p38 mitogen-activated protein kinase inhibitor[1221485-83-1]
    TAK-715inhibitor of p38 MAPK[303162-79-0]
    VX-702P38 MAPK inhibitor[479543-46-9]
    VX-745highly potent and selective p38alpha inhibitor[209410-46-8]

    Browse Tocris compounds for MAPK12 (MK12)

    3 HMDB Compounds for MAPK12    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 DrugBank Compounds for MAPK12    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target----
    Phosphonothreonine-- --target----

    10 Novoseek inferred chemical compound relationships for MAPK12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 56.2 4 12915405 (1), 8633070 (1), 12042304 (1), 17928297 (1)
    sb 203580 52 4 17481747 (1), 10438538 (1), 11095975 (1), 11991731 (1)
    leptomycin b 45.8 2 12915405 (1), 11991731 (1)
    serine 39.8 7 12915405 (1), 8633070 (1), 9199504 (1), 17928297 (1) (see all 5)
    tyrosine 25.3 4 12042304 (2), 17483331 (1), 12297510 (1)
    atp 0 1 9624152 (1)
    nadph 0 1 15167449 (1)
    methionine 0 1 9653550 (1)
    leucine 0 1 11455957 (1)
    alanine 0 1 20236090 (1)



    Find genes that share compounds with MAPK12           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAPK12 gene: 
    NM_002969.3  

    Unigene Cluster for MAPK12:

    Mitogen-activated protein kinase 12
    Hs.432642  [show with all ESTs]
    Unigene Representative Sequence: Y10487
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497036(uc003bko.2 uc003bkm.1 uc003bkl.1) ENST00000395780
    ENST00000488504 ENST00000215659 ENST00000467891 ENST00000496942 ENST00000482969(uc003bkq.2)
    ENST00000497738 ENST00000492218 ENST00000395778(uc010haw.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat MAPK12 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate MAPK12:
    hsa-miR-125a-5p hsa-miR-1283 hsa-miR-670 hsa-miR-125b hsa-miR-198 hsa-miR-4268 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidMAPK12 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: MAPK12 (NM_002969)
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    Addgene plasmids for MAPK12 
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      QuantiFast Probe-based Assays in human, mouse, rat MAPK12

    Additional mRNA sequence: 

    AK289770.1 AK294422.1 AK307421.1 AK307724.1 AK308768.1 BC015741.1 BX640648.1 CR456515.1 
    U66243.1 X79483.1 Y10487.1 

    Selected DOTS entries (see all 28):

    DT.305807  DT.91805671  DT.100804366  DT.75137100  DT.100699275  DT.120663458  DT.100715987  DT.100647979 
    DT.100706843  DT.100720236  DT.100827757  DT.100827760  DT.100827764  DT.100827766  DT.95373439  DT.100647973 
    DT.100687785  DT.100695322  DT.100700034  DT.100708081  DT.100804819  DT.100827769  DT.120663439  DT.92419872 

    Selected AceView cDNA sequences (see all 150):

    BQ687697 CR601459 CR614110 CR604558 CA415888 AW341989 BM718093 BQ941412 
    CR620424 CA431247 CR597558 AW731696 CR617313 NM_002969 BQ433008 H55067 
    BU630279 CR595847 CR597471 CR603767 CR591936 CR600878 BI916114 CK299064 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPK12 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:                    -                             -           -     -                 -     -                       -     -           -                     
    SP2:                    -                             -           -     -           -     -     -                       -     -           -                     
    SP3:                                                              -     -                 -     -                       -     -           -                     
    SP4:                                                  -           -     -                       -                       -     -           -                     
    SP5:                                                  -           -     -     -     -     -     -                       -     -           -                     

    ExUns: 15b ^ 16
    SP1:  -         
    SP2:  -         
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MAPK12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAPK12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAGGAAGG
    MAPK12 Expression
    About this image


    MAPK12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Kidney (Urinary System)
             Metanephros
    MAPK12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432642

    UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
    Tissue specificity: Highly expressed in skeletal muscle and heart

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK12: 
              DNA Damage Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for MAPK12 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk121 , 5 mitogen-activated protein kinase 121, 5 86.01(n)1
    92.64(a)1
      15 (44.65 cM)5
    298571  NM_013871.31  NP_038899.11 
     891305855 
    chicken
    (Gallus gallus)
    Aves MAPK121 mitogen-activated protein kinase 12 73.82(n)
    79.39(a)
      769763  XM_001233061.3  XP_001233062.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK126
    mitogen-activated protein kinase 12
    78(a)
    1 ↔ 1
    5(64196975-64250837)
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ551272.12   -- 74.77(n)    AJ551272.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Y15075.12   -- 77.01(n)   30681  Y15075.1 


    ENSEMBL Gene Tree for MAPK12 (if available)
    TreeFam Gene Tree for MAPK12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK12 gene
    MAPK92  MAPK132  MAPK112  MAPK142  MAPK82  MAPK102  
    Selected SIMAP similar genes for MAPK12 using alignment to 4 protein entries:     MK12_HUMAN (see all proteins) (see all similar genes):
    DKFZp686M02159    MAPK14    MAPK13    MAPK11    DKFZp686O0215    MAPK1
    MAPK9    MAPK3    MAPK10    MAPK8    MAPK7    MAPK4
    MAPK15    NLK    CDKL4    CDKL3    RPS6KA2    CDKL1

    Find genes that share paralogs with MAPK12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPK12 (see all 299)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385824081,2
    C--33589837(+) GCTGCC/TGGGGA 2 Q R mis10--------
    rs2006333391,2
    C--33589881(+) CCTGGC/TGGGGG 1 -- int10--------
    rs20728751,2
    C,F--33589995(+) CTAATG/ATGGTC 1 -- int16Minor allele frequency- A:0.10NA WA EA 364
    rs20761381,2
    C,F--33590082(+) AGGGCT/CTGGCC 1 -- int17Minor allele frequency- C:0.21EA NA WA 1842
    rs1445888301,2
    --33590225(+) AGCCAA/GACTCA 1 -- int10--------
    rs1485133771,2
    --33590229(+) AAACTC/TATAAG 1 -- int10--------
    rs1151458441,2
    C,F--33590239(+) GCACAC/TGAATA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1911645421,2
    --33590292(+) GACCCA/GTGGTC 1 -- int10--------
    rs1843538091,2
    --33590297(+) GTGGTC/GGTAAG 1 -- int10--------
    rs561847131,2
    C,F--33590298(+) TGGTCG/CTAAGG 1 -- int12Minor allele frequency- C:0.26WA 120

    HapMap Linkage Disequilibrium report for MAPK12 (50683879 - 50700254 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAPK12 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471223CNV Loss18288195
    nsv915495CNV Loss21882294
    nsv914517CNV Loss21882294
    dgv5055n71CNV Loss21882294
    nsv914518CNV Loss21882294
    nsv914525CNV Loss21882294
    nsv914524CNV Loss21882294
    dgv5058n71CNV Loss21882294
    nsv914523CNV Loss21882294
    dgv5051n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK12
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602399    OMIM disorders: --

    UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
  • Note=MAPK is overexpressed in highly metastatic breast cancer cell lines and its expression is
    preferentially associated with basal-like and metastatic phenotypes of breast tumor samples


  • Find genes that share disorders with MAPK12           About GenesLikeMe

    6 Novoseek inferred disease relationships for MAPK12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 18.5 1 9029150 (1)
    necrosis 0 1 9029150 (1)
    inflammation 0 2 17482683 (1), 14694199 (1)
    breast cancer 0 5 16885352 (2), 17483331 (2), 19818165 (1)
    tumors 0 3 17850438 (2), 17483331 (1)
    cancer 0 1 16215677 (1)

    Genetic Association Database (GAD): MAPK12
    Human Genome Epidemiology (HuGE) Navigator: MAPK12 (3 documents)

    Export disorders for MAPK12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK12 gene, integrated from 10 sources (see all 182):
    (articles sorted by number of sources associating them with MAPK12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization. (PubMed id 9169156)1, 2, 3, 9 Goedert M.... Clegg S. (Genomics 1997)
    2. Cardiac expression and subcellular localization of the p38 mitogen- activated protein kinase member, stress-activated protein kinase-3 (SAPK3). (PubMed id 11991731)1, 2, 9 Court N.W.... Bogoyevitch M.A. (J. Mol. Cell. Cardiol. 2002)
    3. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. (PubMed id 10848581)1, 2, 9 Wang X.... Han J. (Mol. Cell. Biol. 2000)
    4. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. (PubMed id 8633070)1, 2, 9 Lechner C.... Ullrich A. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    5. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. (PubMed id 10212242)1, 2, 9 Hasegawa M.... Goedert M. (J. Biol. Chem. 1999)
    6. Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death. (PubMed id 21172807)1, 2 Kukkonen-Macchi A.... Kallio M.J. (J. Cell Sci. 2011)
    7. p38gamma mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase- 1 inhibition in breast cancer. (PubMed id 21532888)1, 2 Meng F....Wu G. (Neoplasia 2011)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. (PubMed id 20605917)1, 2 Sabio G.... Cuenda A. (J. Cell Sci. 2010)
    10. p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. (PubMed id 17724032)1, 2 Qi X....Chen G. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6300 HGNC: 6874 AceView: MAPK12 Ensembl:ENSG00000188130 euGenes: HUgn6300
    ECgene: MAPK12 Kegg: 6300 H-InvDB: MAPK12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAPK12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPK12 gene:
    Search GeneIP for patents involving MAPK12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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