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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK12 Gene

protein-coding   GIFtS: 72
GCID: GC22M050684

mitogen-activated protein kinase 12


(Previous symbol: SAPK3)
 Explore 29 diseases affiliated with
MAPK12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAPK12    

Aliases
for MAPK12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase 121 2     MAP Kinase 122 3
SAPK31 2 3 5     MAP Kinase P38 Gamma2 3
ERK61 2 3     MAPK 122 3
PRKM121 2     EC 2.7.11.243 8
SAPK-31 2     ERK32 5
Extracellular Signal-Regulated Kinase 62 3     P38gamma1
Mitogen-Activated Protein Kinase P38 Gamma2 3     P38GAMMA2
Stress-Activated Protein Kinase 32 3     Mitogen-Activated Protein Kinase 32
ERK-62 3     EC 2.7.118

External Ids:    HGNC: 68741   Entrez Gene: 63002   Ensembl: ENSG000001881307   OMIM: 6023995   UniProtKB: P537783   

Export aliases for MAPK12 gene to outside databases

Previous GC identifers: GC22M047242 GC22M048873 GC22M048993 GC22M049033


Summaries
for MAPK12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPK12:
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of
extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this
gene functions as a signal transducer during differentiation of myoblasts to myotubes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by
extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of
transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has
been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases
such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a
role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells
suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following
osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of
DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or
gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint
signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the
regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression
and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14
and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore
localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also
positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and
regeneration

Gene Wiki entry for MAPK12


Genomic Views
for MAPK12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011526.7  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK12 gene promoter:
         CRE-BP1   p53   STAT3   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAPK12 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.3

MAPK12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK12 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050684:  view genomic region     (about GC identifiers)

Start:
 50,683,879 bp from pter      End:
 50,700,254 bp from pter
Size:
 16,376 bases      Orientation:
 minus strand

Proteins
for MAPK12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MK12_HUMAN, P53778 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 12  
Size: 367 amino acids; 41940 Da
Cofactor: Binds 2 magnesium ions
Subunit: Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5. Interacts with LIN7C,
SCRIB and SYNJ2BP (By similarity)
Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal
muscle co-localizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity)
1 PDB 3D structure from and Proteopedia for MAPK12:
1CM8 (3D)    
Secondary accessions: Q14260 Q99588 Q99672

Explore the universe of human proteins at neXtProt for MAPK12: NX_P53778

Post-translational modifications:

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K3/MKK3 and MAP2K6/MKK6, which activates the enzyme1
  • Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P53778

    • 4/16 DME Specific Peptides for MAPK12 (P53778) (see all 16)
     ILDFGLA  LDFGLAR  LLDVFTP  VGSGAYG 

    MAPK12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002960.2  
    ENSEMBL proteins: 
     ENSP00000379126   ENSP00000215659   ENSP00000379124  
    Reactome Protein details: P53778
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAPK12 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MAPK12
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MAPK12
    OriGene Custom Protein Services for MAPK12 
    GenScript Custom Purified and Recombinant Proteins Services for MAPK12
    Novus Biologicals MAPK12 Proteins
    Novus Biologicals MAPK12 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MAPK12
    Uscn Proteins for MAPK12

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--


    MAPK12 for ontologies           About GeneDecksing



    MAPK12 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK12
    R&D Systems Antibodies for MAPK12 (p38 gamma)
    Cell Signaling Technology (CST) Antibodies for MAPK12  (p38-gamma)
    OriGene Antibodies: MAPK12
    OriGene Custom Antibody Services for MAPK12 
    GenScript Custom Superior Antibodies Services for MAPK12
    Novus Biologicals MAPK12 Antibodies
    Abcam antibodies for MAPK12 
    Uscn Antibodies for MAPK12
    ThermoFisher Antibodies for MAPK12

    Assay Products for MAPK12: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for MAPK12 (p38 gamma)         (see all)
    GenScript Custom Assay Services for MAPK12
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK12 (p38-gamma)
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAPK12

    Protein Domains /
    Families
    for MAPK12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPK12 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P53778

    ProtoNet protein and cluster: P53778

    2 Blocks protein families:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAPK12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
    MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by
    extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of
    transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has
    been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases
    such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a
    role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells
    suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following
    osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of
    DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or
    gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint
    signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the
    regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression
    and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14
    and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore
    localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also
    positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and
    regeneration
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on threonine and tyrosine. MAP2K3/MKK3 and MAP2K6/MKK6 are both
    essential for the activation of MAPK12 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK12
    activator in response to TNF-alpha
    Biophysicochemical properties: Kinetic parameters: KM=37 uM for ATP; KM=313 uM for EGFR substrate peptide; KM=254 uM
    for GST-ATF2;
    Induction: Expression of MAPK12 is down-regulation by MAPK14 activation

         Genatlas biochemistry entry for MAPK12:
    mitogen-activated protein kinase 12

    Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MAPK12
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK12
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK12:
    hsa-miR-125a-5p hsa-miR-1283 hsa-miR-670 hsa-miR-125b hsa-miR-198 hsa-miR-4268 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK12 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK12 (see all 7)
    OriGene siRNA: MAPK12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK12

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPK12

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK12 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK12 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAPK12 (NM_002969)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK12 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAPK12
    Search LifeMap BioReagents cell lines for MAPK12

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK12

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA10508788
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15850461
    GO:0004707MAP kinase activity IEA--
    GO:0005515protein binding IPI12761180


    MAPK12 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for MAPK12:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Gemcitabine induced cell-death  Increased cell death HMECs cel 
     PARP inhibitor sensitization 

    Animal Models:
         Mouse knock-out Mapk12tm1Cnd for MAPK12
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mapk12):
     cardiovascular system  cellular  muscle  normal 

    MAPK12 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPK12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/102 super-pathways (see all 102) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1ErbB4 Pathway
    8/12 pathways (see all 12)
    		ErbB4 Pathway1.00
    		Thrombopoietin Pathway0.43
    		ErbB Family Pathway0.59
    		LPS Stimulated MAPK Signaling0.36
    		Prolactin Signaling0.54
    		VEGF Signaling Pathway0.35
    		ErbB2-ErbB3 Heterodimers0.47
    		TREM1 Pathway0.32
    2G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    		G-protein signaling Ras family GTPases in kinase cascades (scheme)1.00
    		Immune response Oncostatin M signaling via MAPK in human cells0.39
    		G-protein signaling_Ras family GTPases in kinase cascades (scheme)1.00
    		Immune response_Role of integrins in NK cells cytotoxicity0.28
    		MAPK Cascade0.44
    		Immune response Role of integrins in NK cells cytotoxicity0.28
    		Immune response_Oncostatin M signaling via MAPK in human cells0.39
    34-1BB Pathway
    		4-1BB Pathway1.00
    		PKR Pathway0.36
    		CD40 Signaling0.54
    		NF-KappaB Activation by EBV0.31
    		CMV and MAPK Pathways0.38
    		SUMO Pathway0.30
    4Toll Comparative Pathway
    		Toll Comparative Pathway1.00
    		Immune response MIF in innate immunity response0.46
    		TLR-TRIF Pathway0.61
    		IL-1 Pathway0.39
    		Immune response_MIF in innate immunity response0.46
    		iNOS Signaling0.34
    5GPCR Pathway
    		GPCR Pathway1.00
    		NFAT in Immune Response0.58
    		Ras Pathway0.62
    		Estrogen Pathway0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/22 EMD Millipore Pathways for MAPK12 (see all 22)
        Development A1 receptor signaling
    Immune response MIF in innate immunity response
    G-protein signaling G-Protein alpha-12 signaling pathway
    Development TGF-beta receptor signaling
    Immune response CCR3 signaling in eosinophils

    3 R&D Systems Pathways for MAPK12
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways
    TGF-beta Signaling Pathways

    5/104 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK12 (see all 104)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPK12
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK12
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    5/24 GeneGo (Thomson Reuters) Pathways for MAPK12 (see all 24)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway

    5/10 BioSystems Pathways for MAPK12 (see all 10) 
        Parkinsons Disease Pathway
    Integrin-mediated cell adhesion
    Signal Transduction of S1P Receptor
    MAPK signaling pathway
    Focal Adhesion

    5/19        Reactome Pathways for MAPK12 (see all 19)
        Developmental Biology
    Nuclear translocation of p38 MAPK
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    p38MAPK events
    Activation of p38 alpha/beta MAPK

    1 PharmGKB Pathway for MAPK12
        VEGF Signaling Pathway

    5/23         Kegg Pathways  (Kegg details for MAPK12) (see all 23):
        MAPK signaling pathway
    Oocyte meiosis
    VEGF signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway


    MAPK12 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/125 Interacting proteins for MAPK12 (P537781, 2, 3 ENSP000002156594) via UniProtKB, MINT, STRING, and/or I2D (see all 125)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNTA1Q134242, 3, ENSP000002173814MINT-59511 I2D: score=3 STRING: ENSP00000217381
    PKN1Q165121, 3, ENSP000003433254EBI-602406,EBI-748186 I2D: score=2 STRING: ENSP00000343325
    DLG1Q129593, ENSP000003457314I2D: score=3 STRING: ENSP00000345731
    MAPKAPK5Q8IW413, ENSP000002027884I2D: score=2 STRING: ENSP00000202788
    DUSP1P285623, ENSP000002392234I2D: score=1 STRING: ENSP00000239223
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation ----
    GO:0006975DNA damage induced protein phosphorylation TAS10848581


    MAPK12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPK12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK12 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK12:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAPK12

    3 HMDB Compounds for MAPK12    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 DrugBank Compounds for MAPK12    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target----
    Phosphonothreonine-- --target----

    10 Novoseek chemical compound relationships for MAPK12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 56.2 4 12915405 (1), 8633070 (1), 12042304 (1), 17928297 (1)
    sb 203580 52 4 17481747 (1), 10438538 (1), 11095975 (1), 11991731 (1)
    leptomycin b 45.8 2 12915405 (1), 11991731 (1)
    serine 39.8 7 12915405 (1), 8633070 (1), 9199504 (1), 17928297 (1) (see all 5)
    tyrosine 25.3 4 12042304 (2), 17483331 (1), 12297510 (1)
    atp 0 1 9624152 (1)
    nadph 0 1 15167449 (1)
    methionine 0 1 9653550 (1)
    leucine 0 1 11455957 (1)
    alanine 0 1 20236090 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK12 / MK12 

    Transcripts
    for MAPK12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPK12 gene: 
    NM_002969.3  

    Unigene Cluster for MAPK12:

    Mitogen-activated protein kinase 12
    Hs.432642  [show with all ESTs]
    Unigene Representative Sequence: Y10487
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497036(uc003bko.2 uc003bkm.1 uc003bkl.1) ENST00000395780
    ENST00000488504 ENST00000215659 ENST00000467891 ENST00000496942 ENST00000482969(uc003bkq.2)
    ENST00000497738 ENST00000492218 ENST00000395778(uc010haw.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MAPK12
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK12
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK12:
    hsa-miR-125a-5p hsa-miR-1283 hsa-miR-670 hsa-miR-125b hsa-miR-198 hsa-miR-4268 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK12 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK12 (see all 7)
    OriGene siRNA: MAPK12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK12
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK12 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK12 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: MAPK12 (NM_002969)
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    Additional cDNA sequence: 

    AK289770.1 AK294422.1 AK307421.1 AK307724.1 AK308768.1 BC015741.1 BX640648.1 CR456515.1 
    U66243.1 X79483.1 Y10487.1 

    24/28 DOTS entries (see all 28):

    DT.305807  DT.91805671  DT.100804366  DT.75137100  DT.100699275  DT.120663458  DT.100715987  DT.100647979 
    DT.100706843  DT.100720236  DT.100827757  DT.100827760  DT.100827764  DT.100827766  DT.95373439  DT.100647973 
    DT.100687785  DT.100695322  DT.100700034  DT.100708081  DT.100804819  DT.100827769  DT.120663439  DT.92419872 

    24/150 AceView cDNA sequences (see all 150):

    BQ941412 CK299064 BQ687697 CR617313 AW341989 CR597471 CR614110 CR604558 
    CR591936 AW731696 BX355236 BU630279 CR603767 BQ433008 CR600878 CR601459 
    BM718093 BI916114 H55067 CR620424 CA415888 CA431247 NM_002969 CR603106 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK12 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:                    -                             -           -     -                 -     -                       -     -           -                     
    SP2:                    -                             -           -     -           -     -     -                       -     -           -                     
    SP3:                                                              -     -                 -     -                       -     -           -                     
    SP4:                                                  -           -     -                       -                       -     -           -                     
    SP5:                                                  -           -     -     -     -     -     -                       -     -           -                     

    ExUns: 15b ^ 16
    SP1:  -         
    SP2:  -         
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MAPK12

    Expression
    for MAPK12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGAGGAAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPK12 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAPK12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK12

    SOURCE GeneReport for Unigene cluster: Hs.432642

    UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
    Tissue specificity: Highly expressed in skeletal muscle and heart

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK12: 
              DNA Damage Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for MAPK12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK12 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAPK121 mitogen-activated protein kinase 12 73.82(n)
    79.39(a)    		   769763  XM_001233061.2  XP_001233062.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPK126
    		 --
    		 78(a)
    		 1 ↔ 1
    		 5(64200631-64250837)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AJ551272.12   -- 74.77(n)    AJ551272.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Y15075.12   -- 77.01(n)   30681  Y15075.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mpk23 immune response protein serine/threonine
    kinase    		 58(a)
    (best of 3)    		   3 95E5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea pmk-13 ser/thr kinases 58(a)
    (best of 4)    		   IV(8148976-8149980)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATMPK46
    MPK116
    (see all 20)    		 mitogen-activated protein kinase 11
    (see all 20)    		 42(a)
    42(a)
    (see all 20)    		 many ↔ many
    many ↔ many
    (see all 20)    		 4(567095-569088)
    1(202136-204335)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 16)    		 CGMC_MAPKCMGC_2_ERK.14 - CGMC includes CDA, MAPK, ...
    CGMC_MAPKCMGC_2_SLT2y_ERK.2 - CGMC includes CDA, M...
    (see all 16)    		 42(a)
    41(a)
    (see all 16)    		 many ↔ many
    many ↔ many
    (see all 16)    		 10(20684568-20688500)
    6(29397209-29401633)


    ENSEMBL Gene Tree for MAPK12 (if available)
    TreeFam Gene Tree for MAPK12 (if available) 

    Paralogs
    for MAPK12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK12 gene
    MAPK92  MAPK132  MAPK112  MAPK142  MAPK102  MAPK82  
    18/51 SIMAP similar genes for MAPK12 using alignment to 4 protein entries:     MK12_HUMAN (see all proteins) (see all similar genes):
    DKFZp686M02159    MAPK14    MAPK13    MAPK11    DKFZp686O0215    MAPK9
    MAPK10    MAPK3    MAPK8    MAPK7    MAPK1    MAPK4
    MAPK6    MAPK15    NLK    CDKL4    CDKL3    RPS6KA2

    MAPK12 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPK12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/233 NCBI SNPs in MAPK12 are shown (see all 233)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs57712751,2
    		C,H--33589364(+) TTCCAG/TGCTGG 3 -- ut31 us2k1 ese36Minor allele frequency- T:0.00NS EA NA 574
    rs1125562281,2
    		F,--33589395(+) ACGTCG/ACCCAG 3 -- us2k1 ut313Minor allele frequency- A:0.04CSA WA 122
    rs561847131,2
    		C,--33590298(+) TGGTCG/CTAAGG 1 -- int12Minor allele frequency- C:0.26WA 120
    rs119120181,2
    		C,H,--33590471(+) GAAGAA/CGACAC 1 -- int12Minor allele frequency- C:0.31WA 120
    rs20098221,2
    		F,--33590770(-) cgcccA/GgccCT 1 -- int11Minor allele frequency- G:0.08WA 118
    rs769762451,2
    		--33591097(+) GGTGTA/GAGCAG 1 -- int10--------
    rs1122183641,2
    		F,--33591466(+) CCTACT/CCGGAG 1 -- int13Minor allele frequency- C:0.43CSA 7
    rs20667741,2
    		C,F,H--33592032(-) TTTGTG/ACAGCG 2 /V syn1 ese35Minor allele frequency- A:0.00NA MN NS 4860
    rs353969051,2
    		C--33592209(+) ACGGTC/TGCTGC 2 N D mis10--------
    rs1125677531,2
    		C,F--33592534(+) ACCACC/TGGGTC 2 Q R mis12Minor allele frequency- T:0.00CSA NA 4548

    HapMap Linkage Disequilibrium report for MAPK12 (50683879 - 50700254 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MAPK12
         1 CNV: 30166

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    Disorders / Diseases
    for MAPK12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPK12 for disorders           About GeneDecksing

    OMIM gene information: 602399    OMIM disorders: --

    UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
  • Note=MAPK is overexpressed in highly metastatic breast cancer cell lines and its expression is preferentially
    • associated with basal-like and metastatic phenotypes of breast tumor samples

    20/29 diseases for MAPK12 (see all 29):    About MalaCards
    amyotrophic lateral sclerosis (als)    amyotrophic lateral sclerosis    lateral sclerosis    oral squamous cell carcinoma
    squamous cell carcinoma    acute lymphoblastic leukemia    lymphoblastic leukemia    chagas disease
    shigellosis    neurodegenerative disease    hepatitis c    trypanosomiasis
    toxoplasmosis    leishmaniasis    breast cancer    pertussis
    hepatocellular carcinoma    alzheimer's disease    influenza    leukemia

    6 Novoseek disease relationships for MAPK12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 18.5 1 9029150 (1)
    necrosis 0 1 9029150 (1)
    inflammation 0 2 17482683 (1), 14694199 (1)
    breast cancer 0 5 16885352 (2), 17483331 (2), 19818165 (1)
    tumors 0 3 17850438 (2), 17483331 (1)
    cancer 0 1 16215677 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAPK12 (3 documents)

    Export disorders for MAPK12 gene to outside databases

    Publications
    for MAPK12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK12 gene, integrated from 9 sources (see all 176):
    (articles sorted by number of sources associating them with MAPK12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization. (PubMed id 9169156)1, 2, 3, 9 Goedert M.... Clegg S. (1997)
    2. Cardiac expression and subcellular localization of the p38 mitogen- activated protein kinase member, stress-activated protein kinase-3 (SAPK3). (PubMed id 11991731)1, 2, 9 Court N.W.... Bogoyevitch M.A. (2002)
    3. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. (PubMed id 10848581)1, 2, 9 Wang X....Han J. (2000)
    4. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. (PubMed id 8633070)1, 2, 9 Lechner C.... Ullrich A. (1996)
    5. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. (PubMed id 10212242)1, 2, 9 Hasegawa M.... Goedert M. (1999)
    6. Loss of p38gamma MAPK induces pleiotropic mitotic def ects and massive cell death. (PubMed id 21172807)1, 2 Kukkonen-Macchi A....Kallio M.J. (2011)
    7. p38gamma mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase- 1 inhibition in breast cancer. (PubMed id 21532888)1, 2 Meng F....Wu G. (2011)
    8. p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. (PubMed id 20605917)1, 2 Sabio G....Cuenda A. (2010)
    9. p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. (PubMed id 17724032)1, 2 Qi X....Chen G. (2007)
    10. Active mutants of the human p38alpha mitogen-activated protein kinase. (PubMed id 15284239)1, 2 Diskin R.... Livnah O. (2004)

    External Searches for MAPK12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAPK12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6300 HGNC: 6874 AceView: MAPK12 Ensembl:ENSG00000188130 euGenes: HUgn6300
    ECgene: MAPK12 Kegg: 6300 H-InvDB: MAPK12

    Other Databases showing MAPK12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAPK12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK12 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAPK12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPK12 gene:
    Search GeneIP for patents involving MAPK12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MAPK12 gene

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    About This Section

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