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Aliases for MAPK12 Gene

Aliases for MAPK12 Gene

  • Mitogen-Activated Protein Kinase 12 2 3 5
  • Mitogen-Activated Protein Kinase P38 Gamma 3 4
  • Extracellular Signal-Regulated Kinase 6 3 4
  • Stress-Activated Protein Kinase 3 3 4
  • MAP Kinase P38 Gamma 3 4
  • MAP Kinase 12 3 4
  • EC 2.7.11.24 4 61
  • MAPK 12 3 4
  • SAPK3 3 4
  • ERK-6 3 4
  • ERK6 3 4
  • Mitogen-Activated Protein Kinase 3 3
  • EC 2.7.11 61
  • P38GAMMA 3
  • PRKM12 3
  • SAPK-3 3
  • ERK3 3

External Ids for MAPK12 Gene

Previous HGNC Symbols for MAPK12 Gene

  • SAPK3

Previous GeneCards Identifiers for MAPK12 Gene

  • GC22M047242
  • GC22M048873
  • GC22M048993
  • GC22M049033
  • GC22M050684

Summaries for MAPK12 Gene

Entrez Gene Summary for MAPK12 Gene

  • Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK12 Gene

MAPK12 (Mitogen-Activated Protein Kinase 12) is a Protein Coding gene. Diseases associated with MAPK12 include Breast Cancer. Among its related pathways are Toll Comparative Pathway and VEGF Signaling Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK13.

UniProtKB/Swiss-Prot for MAPK12 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

Gene Wiki entry for MAPK12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK12 Gene

Genomics for MAPK12 Gene

Regulatory Elements for MAPK12 Gene

Enhancers for MAPK12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F050188 1.5 FANTOM5 ENCODE 22.5 +70.7 70746 5.6 HDGF PKNOX1 ARID4B SIN3A YBX1 ZNF2 ZNF143 ZNF263 MCM3 SP3 TUBGCP6 MAPK12 ALG12 ZBED4 ENSG00000272836 HDAC10 LOC105373095 LOC101928719 MAPK11 PLXNB2
GH22F050249 1 ENCODE 26.7 +10.4 10409 2.9 ARID4B SIN3A ZNF48 BRCA1 ZNF2 ZNF121 SLC30A9 GLIS2 ZNF263 SP3 MAPK12 ALG12 ENSG00000273192 ENSG00000272836 LOC105373095 ZBED4 HDAC10
GH22F050243 1.1 ENCODE 22.5 +16.6 16556 3.7 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MAPK12 SELENOO DENND6B ALG12 LOC105377205 MLC1 TUBGCP6 HDAC10
GH22F050145 1.2 Ensembl ENCODE 17.5 +115.0 114992 2.7 ELF3 ARID4B THRB ZNF48 RAD21 RARA GLIS2 ZNF143 CREM MIXL1 MLC1 MOV10L1 MAPK12 PANX2 TUBGCP6 HDAC10 SELENOO MAPK11 PLXNB2 ENSG00000280395
GH22F050240 0.9 ENCODE 20.4 +20.7 20650 0.9 HDGF HDAC1 PKNOX1 KLF17 ARID4B ZNF48 ZNF2 RAD21 GLIS2 ZNF366 MAPK12 LOC105373095 TUBGCP6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAPK12 on UCSC Golden Path with GeneCards custom track

Promoters for MAPK12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000620198 625 2001 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 GLIS2 ZNF263 SP3

Genomic Location for MAPK12 Gene

Chromosome:
22
Start:
50,245,450 bp from pter
End:
50,261,825 bp from pter
Size:
16,376 bases
Orientation:
Minus strand

Genomic View for MAPK12 Gene

Genes around MAPK12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK12 Gene

Proteins for MAPK12 Gene

  • Protein details for MAPK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53778-MK12_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 12
    Protein Accession:
    P53778
    Secondary Accessions:
    • Q14260
    • Q6IC53
    • Q99588
    • Q99672

    Protein attributes for MAPK12 Gene

    Size:
    367 amino acids
    Molecular mass:
    41940 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5. Interacts with LIN7C, SCRIB and SYNJ2BP (By similarity).

    Three dimensional structures from OCA and Proteopedia for MAPK12 Gene

    Alternative splice isoforms for MAPK12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK12 Gene

Selected DME Specific Peptides for MAPK12 Gene

P53778:
  • QTVDIWSVGCIMAE
  • LVYQMLKGL
  • EMTGYVVTRWYRAPEVIL
  • ILDFGLA
  • YRELRLLKHM
  • AKRAYRE
  • AVNEDCEL
  • DIWSVGCI
  • DFYLVMPFMGTDLGKLMK
  • HENVIGLLD
  • LDFGLAR
  • LLDVFTP
  • VGSGAYG
  • TRWYRAPE
  • HRDLKPGN
  • LKILDFGLAR

Post-translational modifications for MAPK12 Gene

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K3/MKK3 and MAP2K6/MKK6, which activates the enzyme.
  • Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK12 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPK12 (P38G)
  • Cloud-Clone Corp. Antibodies for MAPK12

Domains & Families for MAPK12 Gene

Suggested Antigen Peptide Sequences for MAPK12 Gene

Graphical View of Domain Structure for InterPro Entry

P53778

UniProtKB/Swiss-Prot:

MK12_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK12: view

Function for MAPK12 Gene

Molecular function for MAPK12 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase 12
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=37 uM for ATP {ECO:0000269 PubMed:10212242}; KM=313 uM for EGFR substrate peptide {ECO:0000269 PubMed:10212242}; KM=254 uM for GST-ATF2 {ECO:0000269 PubMed:10212242};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on threonine and tyrosine. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK12 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK12 activator in response to TNF-alpha.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
UniProtKB/Swiss-Prot Induction:
Expression of MAPK12 is down-regulation by MAPK14 activation.

Enzyme Numbers (IUBMB) for MAPK12 Gene

Gene Ontology (GO) - Molecular Function for MAPK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 10508788
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS 18221368
GO:0004707 MAP kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with MAPK12: view
genes like me logo Genes that share phenotypes with MAPK12: view

Animal Models for MAPK12 Gene

MGI Knock Outs for MAPK12:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MAPK12 Gene

Localization for MAPK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK12 Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAPK12 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MAPK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPK12: view

Pathways & Interactions for MAPK12 Gene

genes like me logo Genes that share pathways with MAPK12: view

Pathways by source for MAPK12 Gene

SIGNOR curated interactions for MAPK12 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAPK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006975 DNA damage induced protein phosphorylation TAS 10848581
genes like me logo Genes that share ontologies with MAPK12: view

Drugs & Compounds for MAPK12 Gene

(28) Drugs for MAPK12 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
Phosphonothreonine Experimental Pharma Target 0
VX-702 Investigational Pharma inhibitor P38α MAPK inhibitor,highly selective and ATP-competitive 0
KC706 Investigational Pharma inhibitor, Target 0

(3) Additional Compounds for MAPK12 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(9) ApexBio Compounds for MAPK12 Gene

Compound Action Cas Number
BIRB 796 (Doramapimod) P38 MAPK inhibitor,cell permeable and highly selective 285983-48-4
Losmapimod 585543-15-3
LY2228820 P38 MAP kinase inhibitor 862507-23-1
PH-797804 P38 MAP kinase inhibitor, potent and selective 586379-66-0
SB 203580 P38 MAP kinase inhibitor 152121-47-6
SB202190 (FHPI) P38 MAPK inhibitor 152121-30-7
Skepinone-L P38-MAPK inhibitor,potent and selective 1221485-83-1
TAK-715 p38 MAPK inhibitor 303162-79-0
VX-702 P38α MAPK inhibitor,highly selective and ATP-competitive 479543-46-9
genes like me logo Genes that share compounds with MAPK12: view

Transcripts for MAPK12 Gene

Unigene Clusters for MAPK12 Gene

Mitogen-activated protein kinase 12:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK12 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - - - - - - -
SP10: - - -
SP11: -
SP12: -
SP13:

ExUns: 15b ^ 16
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MAPK12 Gene

GeneLoc Exon Structure for
MAPK12
ECgene alternative splicing isoforms for
MAPK12

Expression for MAPK12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAPK12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK12 Gene

This gene is overexpressed in Muscle - Skeletal (x15.0).

Protein differential expression in normal tissues from HIPED for MAPK12 Gene

This gene is overexpressed in Tonsil (29.1) and Peripheral blood mononuclear cells (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAPK12 Gene



NURSA nuclear receptor signaling pathways regulating expression of MAPK12 Gene:

MAPK12

SOURCE GeneReport for Unigene cluster for MAPK12 Gene:

Hs.432642

mRNA Expression by UniProt/SwissProt for MAPK12 Gene:

P53778-MK12_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and heart.
genes like me logo Genes that share expression patterns with MAPK12: view

No data available for Protein tissue co-expression partners for MAPK12 Gene

Orthologs for MAPK12 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK12 34 35
  • 93.55 (n)
cow
(Bos Taurus)
Mammalia MAPK12 34 35
  • 90.64 (n)
dog
(Canis familiaris)
Mammalia MAPK12 34 35
  • 90.19 (n)
rat
(Rattus norvegicus)
Mammalia Mapk12 34
  • 86.56 (n)
mouse
(Mus musculus)
Mammalia Mapk12 34 16 35
  • 86.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK12 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPK12 34 35
  • 73.82 (n)
lizard
(Anolis carolinensis)
Reptilia MAPK12 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk12 34
  • 70.44 (n)
zebrafish
(Danio rerio)
Actinopterygii mapk12a 35
  • 69 (a)
OneToMany
mapk12b 34 35
  • 67.13 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Mpk2 36
  • 58 (a)
p38b 36
  • 57 (a)
p38c 36
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea pmk-1 36
  • 58 (a)
pmk-3 36
  • 41 (a)
F09C12.2 36
  • 37 (a)
Y51B9A.9 36
  • 32 (a)
Species where no ortholog for MAPK12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK12 Gene

ENSEMBL:
Gene Tree for MAPK12 (if available)
TreeFam:
Gene Tree for MAPK12 (if available)

Paralogs for MAPK12 Gene

Variants for MAPK12 Gene

Sequence variations from dbSNP and Humsavar for MAPK12 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1076649 -- 50,259,089(-) TCCCC(A/G)TTTAA intron-variant
rs1076650 -- 50,259,207(-) TTGCC(C/T)ATGGC intron-variant
rs111326730 -- 50,257,278(+) AGACC(C/T)GTCCC intron-variant
rs111600690 -- 50,255,155(+) CCCCC(A/C/G/T)ACTTG intron-variant
rs111981253 -- 50,258,654(+) AGATC(C/T)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAPK12 Gene

Variant ID Type Subtype PubMed ID
nsv955199 CNV deletion 24416366
nsv471223 CNV loss 18288195
nsv1066496 CNV loss 25217958
dgv781n67 CNV gain 20364138

Variation tolerance for MAPK12 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.52; 71.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAPK12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK12 Gene

Disorders for MAPK12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAPK12 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MK12_HUMAN
  • Note=MAPK is overexpressed in highly metastatic breast cancer cell lines and its expression is preferentially associated with basal-like and metastatic phenotypes of breast tumor samples.

Relevant External Links for MAPK12

Genetic Association Database (GAD)
MAPK12
Human Genome Epidemiology (HuGE) Navigator
MAPK12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK12
genes like me logo Genes that share disorders with MAPK12: view

No data available for Genatlas for MAPK12 Gene

Publications for MAPK12 Gene

  1. Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization. (PMID: 9169156) Goedert M. … Clegg S. (Genomics 1997) 2 3 4 22 64
  2. Cardiac expression and subcellular localization of the p38 mitogen- activated protein kinase member, stress-activated protein kinase-3 (SAPK3). (PMID: 11991731) Court N.W. … Bogoyevitch M.A. (J. Mol. Cell. Cardiol. 2002) 3 4 22 64
  3. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. (PMID: 10848581) Wang X. … Han J. (Mol. Cell. Biol. 2000) 3 4 22 64
  4. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. (PMID: 10212242) Hasegawa M. … Goedert M. (J. Biol. Chem. 1999) 3 4 22 64
  5. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. (PMID: 8633070) Lechner C. … Ullrich A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 22 64

Products for MAPK12 Gene

Sources for MAPK12 Gene

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