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Aliases for MAPK12 Gene

Aliases for MAPK12 Gene

  • Mitogen-Activated Protein Kinase 12 2 3
  • SAPK3 3 4 6
  • Mitogen-Activated Protein Kinase P38 Gamma 3 4
  • Extracellular Signal-Regulated Kinase 6 3 4
  • Stress-Activated Protein Kinase 3 3 4
  • MAP Kinase P38 Gamma 3 4
  • MAP Kinase 12 3 4
  • EC 2.7.11.24 4 63
  • MAPK 12 3 4
  • ERK-6 3 4
  • ERK3 3 6
  • ERK6 3 4
  • Mitogen-Activated Protein Kinase 3 3
  • EC 2.7.11 63
  • P38GAMMA 3
  • PRKM12 3
  • SAPK-3 3

External Ids for MAPK12 Gene

Previous HGNC Symbols for MAPK12 Gene

  • SAPK3

Previous GeneCards Identifiers for MAPK12 Gene

  • GC22M047242
  • GC22M048873
  • GC22M048993
  • GC22M049033
  • GC22M050684

Summaries for MAPK12 Gene

Entrez Gene Summary for MAPK12 Gene

  • Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK12 Gene

MAPK12 (Mitogen-Activated Protein Kinase 12) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase activity. An important paralog of this gene is MAPK11.

UniProtKB/Swiss-Prot for MAPK12 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

Gene Wiki entry for MAPK12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK12 Gene

Genomics for MAPK12 Gene

Regulatory Elements for MAPK12 Gene

Genomic Location for MAPK12 Gene

Start:
50,245,450 bp from pter
End:
50,261,825 bp from pter
Size:
16,376 bases
Orientation:
Minus strand

Genomic View for MAPK12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK12 Gene

Proteins for MAPK12 Gene

  • Protein details for MAPK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53778-MK12_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 12
    Protein Accession:
    P53778
    Secondary Accessions:
    • Q14260
    • Q6IC53
    • Q99588
    • Q99672

    Protein attributes for MAPK12 Gene

    Size:
    367 amino acids
    Molecular mass:
    41940 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions.;
    Quaternary structure:
    • Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5. Interacts with LIN7C, SCRIB and SYNJ2BP (By similarity).

    Three dimensional structures from OCA and Proteopedia for MAPK12 Gene

    Alternative splice isoforms for MAPK12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK12 Gene

Proteomics data for MAPK12 Gene at MOPED

Post-translational modifications for MAPK12 Gene

  • Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K3/MKK3 and MAP2K6/MKK6, which activates the enzyme.
  • Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPK12 (P38G)

Protein Products

  • Enzo Life Sciences proteins for MAPK12

Domains for MAPK12 Gene

Gene Families for MAPK12 Gene

Suggested Antigen Peptide Sequences for MAPK12 Gene

Graphical View of Domain Structure for InterPro Entry

P53778

UniProtKB/Swiss-Prot:

MK12_HUMAN :
  • P53778
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK12: view

Function for MAPK12 Gene

Molecular function for MAPK12 Gene

GENATLAS Biochemistry: mitogen-activated protein kinase 12
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=37 uM for ATP {ECO:0000269 PubMed:10212242}; KM=313 uM for EGFR substrate peptide {ECO:0000269 PubMed:10212242}; KM=254 uM for GST-ATF2 {ECO:0000269 PubMed:10212242};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on threonine and tyrosine. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK12 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK12 activator in response to TNF-alpha.
UniProtKB/Swiss-Prot Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
UniProtKB/Swiss-Prot Induction: Expression of MAPK12 is down-regulation by MAPK14 activation.

Enzyme Numbers (IUBMB) for MAPK12 Gene

Gene Ontology (GO) - Molecular Function for MAPK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10508788
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS 18221368
GO:0004707 MAP kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with MAPK12: view
genes like me logo Genes that share phenotypes with MAPK12: view

Animal Models for MAPK12 Gene

MGI Knock Outs for MAPK12:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for MAPK12 Gene

Localization for MAPK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK12 Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK12 Gene COMPARTMENTS Subcellular localization image for MAPK12 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for MAPK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPK12: view

Pathways for MAPK12 Gene

genes like me logo Genes that share pathways with MAPK12: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MAPK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS 10848581
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation --
GO:0006975 DNA damage induced protein phosphorylation TAS 10848581
genes like me logo Genes that share ontologies with MAPK12: view

Compounds for MAPK12 Gene

(10) ApexBio Compounds for MAPK12 Gene

Compound Action Cas Number
BIRB 796 (Doramapimod) Cell pemeable p38 MAP Kinase Inhibitor [285983-48-4]
LY2228820 Potent and ATP-competitive p38 MAP kinase inhibitor [862507-23-1]
PD 169316 p38 MAPK inhibitor [152121-53-4]
PH-797804 Potent and selective p38 MAP kinase inhibitor [586379-66-0]
SB 203580 Cell permeable, reversible, and ATP-competitive p38 MAP kinase inhibitor [152121-47-6]
SB202190 (FHPI) highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. [152121-30-7]
Skepinone-L selective p38 mitogen-activated protein kinase inhibitor. [1221485-83-1]
TAK-715 inhibitor of p38 MAPK [303162-79-0]
VX-702 P38 MAPK inhibitor [479543-46-9]
VX-745 highly potent and selective p38alpha inhibitor [209410-46-8]

(3) HMDB Compounds for MAPK12 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(2) Drugbank Compounds for MAPK12 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Phosphoaminophosphonic Acid-Adenylate Ester
target
Phosphonothreonine
target

(10) Novoseek inferred chemical compound relationships for MAPK12 Gene

Compound -log(P) Hits PubMed IDs
threonine 56.2 4
sb 203580 52 4
leptomycin b 45.8 2
serine 39.8 5
tyrosine 25.3 4
genes like me logo Genes that share compounds with MAPK12: view

Transcripts for MAPK12 Gene

Unigene Clusters for MAPK12 Gene

Mitogen-activated protein kinase 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAPK12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK12 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: - - - - - - -
SP10: - - -
SP11: -
SP12: -
SP13:

ExUns: 15b ^ 16
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MAPK12 Gene

GeneLoc Exon Structure for
MAPK12
ECgene alternative splicing isoforms for
MAPK12

Expression for MAPK12 Gene

mRNA expression in normal human tissues for MAPK12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK12 Gene

This gene is overexpressed in Muscle - Skeletal (15.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK12 Gene

SOURCE GeneReport for Unigene cluster for MAPK12 Gene Hs.432642

mRNA Expression by UniProt/SwissProt for MAPK12 Gene

P53778-MK12_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and heart.
genes like me logo Genes that share expressions with MAPK12: view

In Situ Assay Products

Orthologs for MAPK12 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK12 35
  • 93.55 (n)
  • 92.79 (a)
MAPK12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK12 35
  • 90.64 (n)
  • 92.92 (a)
MAPK12 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK12 35
  • 90.19 (n)
  • 93.99 (a)
MAPK12 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk12 35
  • 86.01 (n)
  • 92.64 (a)
Mapk12 16
Mapk12 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK12 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk12 35
  • 86.56 (n)
  • 93.73 (a)
chicken
(Gallus gallus)
Aves MAPK12 35
  • 73.82 (n)
  • 79.39 (a)
MAPK12 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK12 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk12 35
  • 70.44 (n)
  • 77.34 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
mapk12a 36
  • 69 (a)
OneToMany
mapk12b 35
  • 67.13 (n)
  • 69.44 (a)
mapk12b 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mpk2 37
  • 58 (a)
p38b 37
  • 57 (a)
p38c 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea Y51B9A.9 37
  • 32 (a)
pmk-3 37
  • 41 (a)
F09C12.2 37
  • 37 (a)
pmk-1 37
  • 58 (a)
Species with no ortholog for MAPK12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK12 Gene

ENSEMBL:
Gene Tree for MAPK12 (if available)
TreeFam:
Gene Tree for MAPK12 (if available)

Paralogs for MAPK12 Gene

Paralogs for MAPK12 Gene

genes like me logo Genes that share paralogs with MAPK12: view

Variants for MAPK12 Gene

Sequence variations from dbSNP and Humsavar for MAPK12 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs742184 -- 50,258,690(+) GAGGC(C/T)AGGCC intron-variant
rs1076649 -- 50,259,089(-) TCCCC(A/G)TTTAA intron-variant
rs1076650 -- 50,259,207(-) TTGCC(C/T)ATGGC intron-variant
rs1129880 -- 50,255,868(-) TGGTC(C/T)GTGGG synonymous-codon, reference
rs1129881 -- 50,255,522(-) AGAAC(A/T)ACATG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for MAPK12 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
dgv781n67 CNV Gain 20364138
dgv5055n71 CNV Loss 21882294
nsv914515 CNV Gain 21882294
nsv471223 CNV Loss 18288195
nsv914517 CNV Loss 21882294
nsv914518 CNV Loss 21882294
dgv5058n71 CNV Loss 21882294
nsv914523 CNV Loss 21882294
nsv914524 CNV Loss 21882294
nsv914525 CNV Loss 21882294

Relevant External Links for MAPK12 Gene

HapMap Linkage Disequilibrium report
MAPK12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK12 Gene

Disorders for MAPK12 Gene

UniProtKB/Swiss-Prot

MK12_HUMAN
  • Note=MAPK is overexpressed in highly metastatic breast cancer cell lines and its expression is preferentially associated with basal-like and metastatic phenotypes of breast tumor samples.

(6) Novoseek inferred disease relationships for MAPK12 Gene

Disease -log(P) Hits PubMed IDs
shock 18.5 1
necrosis 0 1
inflammation 0 2
breast cancer 0 5
tumors 0 3

Relevant External Links for MAPK12

Genetic Association Database (GAD)
MAPK12
Human Genome Epidemiology (HuGE) Navigator
MAPK12
genes like me logo Genes that share disorders with MAPK12: view

Publications for MAPK12 Gene

  1. Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization. (PMID: 9169156) Goedert M. … Clegg S. (Genomics 1997) 2 3 4 23
  2. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. (PMID: 8633070) Lechner C. … Ullrich A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  3. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. (PMID: 10212242) Hasegawa M. … Goedert M. (J. Biol. Chem. 1999) 3 4 23
  4. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. (PMID: 10848581) Wang X. … Han J. (Mol. Cell. Biol. 2000) 3 4 23
  5. Cardiac expression and subcellular localization of the p38 mitogen- activated protein kinase member, stress-activated protein kinase-3 (SAPK3). (PMID: 11991731) Court N.W. … Bogoyevitch M.A. (J. Mol. Cell. Cardiol. 2002) 3 4 23

Products for MAPK12 Gene

Sources for MAPK12 Gene

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