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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK12 Gene

protein-coding   GIFtS: 75
GCID: GC22M050684

Mitogen-Activated Protein Kinase 12


(Previous symbol: SAPK3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase 121 2     MAPK 122 3
SAPK31 2 3 5     EC 2.7.11.243 8
Extracellular Signal-Regulated Kinase 62 3     ERK32 5
Mitogen-Activated Protein Kinase P38 Gamma2 3     P38GAMMA2
Stress-Activated Protein Kinase 32 3     PRKM122
ERK-62 3     SAPK-32
ERK62 3     Mitogen-Activated Protein Kinase 32
MAP Kinase 122 3     EC 2.7.118
MAP Kinase P38 Gamma2 3     

External Ids:    HGNC: 68741   Entrez Gene: 63002   Ensembl: ENSG000001881307   OMIM: 6023995   UniProtKB: P537783   

Export aliases for MAPK12 gene to outside databases

Previous GC identifers: GC22M047242 GC22M048873 GC22M048993 GC22M049033


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPK12 Gene:
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of
extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by
this gene functions as a signal transducer during differentiation of myoblasts to myotubes. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MAPK12 Gene: 
MAPK12 (mitogen-activated protein kinase 12) is a protein-coding gene. Diseases associated with MAPK12 include trypanosomiasis, and shigellosis, and among its related super-pathways are Development FGF-family signaling and TLR-TRIF Pathway. GO annotations related to this gene include MAP kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is MAPK9.

UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins
and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are
downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate
additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in
response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting
differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its
association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent
of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to
osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA
damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression
and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated
glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by
MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of
PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively
regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration

Gene Wiki entry for MAPK12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011526.7  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK12 gene promoter:
         CRE-BP1   p53   STAT3   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPK12 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.3

MAPK12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK12 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050684:  view genomic region     (about GC identifiers)

Start:
50,683,879 bp from pter      End:
50,700,254 bp from pter
Size:
16,376 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MK12_HUMAN, P53778 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 12  
Size: 367 amino acids; 41940 Da
Cofactor: Binds 2 magnesium ions
Subunit: Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5. Interacts with
LIN7C, SCRIB and SYNJ2BP (By similarity)
Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In
skeletal muscle co-localizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By
similarity)
1 PDB 3D structure from and Proteopedia for MAPK12:
1CM8 (3D)    
Secondary accessions: Q14260 Q99588 Q99672

Explore the universe of human proteins at neXtProt for MAPK12: NX_P53778

Explore proteomics data for MAPK12 at MOPED 

Post-translational modifications:

  • UniProtKB: Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K3/MKK3 and MAP2K6/MKK6, which activates the enzyme
  • UniProtKB: Ubiquitinated. Ubiquitination leads to degradation by the proteasome pathway
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53778

  • 4/16 DME Specific Peptides for MAPK12 (P53778) (see all 16)
     ILDFGLA  LDFGLAR  LLDVFTP  VGSGAYG 

    MAPK12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAPK12 Protein Expression
    REFSEQ proteins: NP_002960.2  
    ENSEMBL proteins: 
     ENSP00000379126   ENSP00000215659   ENSP00000379124  
    Reactome Protein details: P53778
    Human Recombinant Protein Products for MAPK12: 
    EMD Millipore Purified and/or Recombinant MAPK12 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MAPK12
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MAPK12
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MAPK12
    GenScript Custom Purified and Recombinant Proteins Services for MAPK12
    Novus Biologicals MAPK12 Proteins
    Novus Biologicals MAPK12 Lysates
    Sino Biological Recombinant Protein for MAPK12
    Sino Biological Cell Lysate for MAPK12 
    ProSpec Recombinant Protein for MAPK12
    Cloud-Clone Corp. Proteins for MAPK12 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    MAPK12 for ontologies           About GeneDecksing



    MAPK12 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK12
    R&D Systems Antibodies for MAPK12 (p38 gamma)
    Cell Signaling Technology (CST) Antibodies for MAPK12  (P38G)
    OriGene Antibodies for MAPK12
    OriGene Custom Antibody Services for MAPK12
    GenScript Custom Superior Antibodies Services for MAPK12
    Novus Biologicals MAPK12 Antibodies
    Abcam antibodies for MAPK12
    Cloud-Clone Corp. Antibodies for MAPK12 
    ThermoFisher Antibody for MAPK12
    LSBio Antibodies in human, mouse, rat for MAPK12 

    Assay Products for MAPK12: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAPK12
    R&D Systems ELISAs for MAPK12 (p38 gamma)         (see all)
    GenScript Custom Assay Services for MAPK12
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK12 (P38G)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK12 
    Cloud-Clone Corp. CLIAs for MAPK12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 12 
    p38 subfamily
    Mitogen-activated protein kinases

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P53778

    ProtoNet protein and cluster: P53778

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK12_HUMAN, P53778
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
    evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
    of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins
    and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are
    downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate
    additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in
    response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting
    differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its
    association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent
    of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to
    osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA
    damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression
    and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated
    glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by
    MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of
    PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively
    regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on threonine and tyrosine. MAP2K3/MKK3 and MAP2K6/MKK6 are both
    essential for the activation of MAPK12 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK12
    activator in response to TNF-alpha
    Biophysicochemical properties: Kinetic parameters: KM=37 uM for ATP; KM=313 uM for EGFR substrate peptide; KM=254
    uM for GST-ATF2;
    Induction: Expression of MAPK12 is down-regulation by MAPK14 activation

         Genatlas biochemistry entry for MAPK12:
    mitogen-activated protein kinase 12

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA10508788
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15850461
    GO:0004707MAP kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    MAPK12 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAPK12:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Gemcitabine induced cell-death  Increased cell death HMECs cel 
     PARP inhibitor sensitization 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mapk12):
     cardiovascular system  cellular  muscle  normal 

    MAPK12 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mapk12tm1Cnd for MAPK12

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAPK12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAPK12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK12 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK12
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK12:
    hsa-miR-125a-5p hsa-miR-1283 hsa-miR-670 hsa-miR-125b hsa-miR-198 hsa-miR-4268 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidMAPK12 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAPK12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK12
    Sirion Biotech Customized adenovirus for overexpression of MAPK12

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAPK12 (see all 9)
    OriGene ORF clones in mouse, rat for MAPK12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK12 (NM_002969)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK12
    Sirion Biotech Customized lentivirus for stable overexpression of MAPK12 
                         Customized lentivirus expression plasmids for stable overexpression of MAPK12 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK12
    Search LifeMap BioReagents cell lines for MAPK12
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAPK12 About   (see all 113)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development FGF-family signaling
    Development FGF-family signaling0.63
    Development Flt3 signaling0.45
    Development FGFR signaling pathway0.50
    FGF Pathway0.38
    2Toll Comparative Pathway
    Toll Comparative Pathway0.61
    IL-1 Pathway0.39
    TLR-TRIF Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    3Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.69
    4G-protein signaling Ras family GTPases in kinase cascades (scheme)
    G-protein signaling Ras family GTPases in kinase cascades (scheme)0.44
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    MAPK Cascade0.44
    5Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    VEGF signaling pathway0.39
    Fc epsilon RI signaling pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/22 EMD Millipore Pathways for MAPK12 (see all 22)
        Development A1 receptor signaling
    Immune response MIF in innate immunity response
    G-protein signaling G-Protein alpha-12 signaling pathway
    Development TGF-beta receptor signaling
    Immune response CCR3 signaling in eosinophils

    5/7 R&D Systems Pathways for MAPK12 (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/104 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK12 (see all 104)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPK12
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK12
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    5/24 GeneGo (Thomson Reuters) Pathways for MAPK12 (see all 24)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway

    5/10 BioSystems Pathways for MAPK12 (see all 10)
        MAPK signaling pathway
    Focal Adhesion
    Insulin Signaling
    Integrin-mediated cell adhesion
    Signal Transduction of S1P Receptor

    2 Sino Biological Pathways for MAPK12 
        Notch Signaling Pathway
    TGF-beta Signaling Pathway

    5/15        Reactome Pathways for MAPK12 (see all 15)
        Developmental Biology
    Myogenesis
    Signalling to RAS
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    DSCAM interactions

    1 PharmGKB Pathway for MAPK12
        VEGF Signaling Pathway

    5/30         Kegg Pathways  (Kegg details for MAPK12) (see all 30):
        MAPK signaling pathway
    Oocyte meiosis
    VEGF signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway


    MAPK12 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/126 Interacting proteins for MAPK12 (P537781, 2, 3 ENSP000002156594) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PKN1Q165121, 3, ENSP000003433254EBI-602406,EBI-602382 I2D: score=2 STRING: ENSP00000343325
    SNTA1Q134242, 3, ENSP000002173814MINT-59511 I2D: score=3 STRING: ENSP00000217381
    DUSP1P285623, ENSP000002392234I2D: score=1 STRING: ENSP00000239223
    EEF2KO004183, ENSP000002630264I2D: score=1 STRING: ENSP00000263026
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation ----
    GO:0006975DNA damage induced protein phosphorylation TAS10848581

    MAPK12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK12 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK12:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAPK12 (MK12)

    3 HMDB Compounds for MAPK12    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 DrugBank Compounds for MAPK12    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target----
    Phosphonothreonine-- --target----

    10 Novoseek inferred chemical compound relationships for MAPK12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 56.2 4 12915405 (1), 8633070 (1), 12042304 (1), 17928297 (1)
    sb 203580 52 4 17481747 (1), 10438538 (1), 11095975 (1), 11991731 (1)
    leptomycin b 45.8 2 12915405 (1), 11991731 (1)
    serine 39.8 7 12915405 (1), 8633070 (1), 9199504 (1), 17928297 (1) (see all 5)
    tyrosine 25.3 4 12042304 (2), 17483331 (1), 12297510 (1)
    atp 0 1 9624152 (1)
    nadph 0 1 15167449 (1)
    methionine 0 1 9653550 (1)
    leucine 0 1 11455957 (1)
    alanine 0 1 20236090 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK12 / MK12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAPK12 gene: 
    NM_002969.3  

    Unigene Cluster for MAPK12:

    Mitogen-activated protein kinase 12
    Hs.432642  [show with all ESTs]
    Unigene Representative Sequence: Y10487
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497036(uc003bko.2 uc003bkm.1 uc003bkl.1) ENST00000395780
    ENST00000488504 ENST00000215659 ENST00000467891 ENST00000496942 ENST00000482969(uc003bkq.2)
    ENST00000497738 ENST00000492218 ENST00000395778(uc010haw.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK12
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK12:
    hsa-miR-125a-5p hsa-miR-1283 hsa-miR-670 hsa-miR-125b hsa-miR-198 hsa-miR-4268 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidMAPK12 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAPK12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK12
    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK12 (see all 9)
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    Additional mRNA sequence: 

    AK289770.1 AK294422.1 AK307421.1 AK307724.1 AK308768.1 BC015741.1 BX640648.1 CR456515.1 
    U66243.1 X79483.1 Y10487.1 

    24/28 DOTS entries (see all 28):

    DT.305807  DT.91805671  DT.100804366  DT.75137100  DT.100699275  DT.120663458  DT.100715987  DT.100647979 
    DT.100706843  DT.100720236  DT.100827757  DT.100827760  DT.100827764  DT.100827766  DT.95373439  DT.100647973 
    DT.100687785  DT.100695322  DT.100700034  DT.100708081  DT.100804819  DT.100827769  DT.120663439  DT.92419872 

    24/150 AceView cDNA sequences (see all 150):

    CR597471 CR603767 BU630279 BQ433008 CR595847 BQ941412 BI916114 H55067 
    BX355236 CR614110 CR604558 CR617313 CA415888 BQ687697 CR620424 AW341989 
    CA431247 CR600878 BM718093 CR591936 CR601459 CR597558 AW731696 CR603106 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK12 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:                    -                             -           -     -                 -     -                       -     -           -                     
    SP2:                    -                             -           -     -           -     -     -                       -     -           -                     
    SP3:                                                              -     -                 -     -                       -     -           -                     
    SP4:                                                  -           -     -                       -                       -     -           -                     
    SP5:                                                  -           -     -     -     -     -     -                       -     -           -                     

    ExUns: 15b ^ 16
    SP1:  -         
    SP2:  -         
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for MAPK12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK12 expression in normal human tissues (normalized intensities)      MAPK12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAGGAAGG
    MAPK12 Expression
    About this image


    MAPK12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             vastus lateralis   
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Neuron (Nervous System)
             nerve   
     
     Kidney (Urinary System)
             Metanephros
     
     Uterus (Reproductive System)
             CERVIX   

    See MAPK12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK12

    SOURCE GeneReport for Unigene cluster: Hs.432642

    UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
    Tissue specificity: Highly expressed in skeletal muscle and heart

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK12: 
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              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MAPK12 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk121 , 5 mitogen-activated protein kinase 121, 5 86.01(n)1
    92.64(a)1
      15 (44.65 cM)5
    298571  NM_013871.31  NP_038899.11 
     891305855 
    chicken
    (Gallus gallus)
    Aves MAPK121 mitogen-activated protein kinase 12 73.82(n)
    79.39(a)
      769763  XM_001233061.2  XP_001233062.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK126
    Uncharacterized protein
    77(a)
    1 ↔ 1
    5(64196975-64250837)
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ551272.12   -- 74.77(n)    AJ551272.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Y15075.12   -- 77.01(n)   30681  Y15075.1 


    ENSEMBL Gene Tree for MAPK12 (if available)
    TreeFam Gene Tree for MAPK12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK12 gene
    MAPK92  MAPK132  MAPK112  MAPK142  MAPK82  MAPK102  
    18/50 SIMAP similar genes for MAPK12 using alignment to 4 protein entries:     MK12_HUMAN (see all proteins) (see all similar genes):
    DKFZp686M02159    MAPK14    MAPK13    MAPK11    DKFZp686O0215    MAPK9
    MAPK3    MAPK10    MAPK8    MAPK7    MAPK1    MAPK4
    MAPK6    MAPK15    NLK    CDKL4    CDKL3    RPS6KA2

    MAPK12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/299 SNPs in MAPK12 are shown (see all 299)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385824081,2
    C--33589837(+) GCTGCC/TGGGGA 2 Q R mis10--------
    rs2006333391,2
    C--33589881(+) CCTGGC/TGGGGG 1 -- int10--------
    rs20728751,2
    C,F--33589995(+) CTAATG/ATGGTC 1 -- int16Minor allele frequency- A:0.10NA WA EA 364
    rs20761381,2
    C,F--33590082(+) AGGGCT/CTGGCC 1 -- int17Minor allele frequency- C:0.21EA NA WA 1842
    rs1445888301,2
    --33590225(+) AGCCAA/GACTCA 1 -- int10--------
    rs1485133771,2
    --33590229(+) AAACTC/TATAAG 1 -- int10--------
    rs1151458441,2
    C,F--33590239(+) GCACAC/TGAATA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1911645421,2
    --33590292(+) GACCCA/GTGGTC 1 -- int10--------
    rs1843538091,2
    --33590297(+) GTGGTC/GGTAAG 1 -- int10--------
    rs561847131,2
    C,F--33590298(+) TGGTCG/CTAAGG 1 -- int12Minor allele frequency- C:0.26WA 120

    HapMap Linkage Disequilibrium report for MAPK12 (50683879 - 50700254 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for MAPK12 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv471223CNV Loss18288195
    nsv915495CNV Loss21882294
    nsv914517CNV Loss21882294
    dgv5055n71CNV Loss21882294
    nsv914518CNV Loss21882294
    nsv914525CNV Loss21882294
    nsv914524CNV Loss21882294
    dgv5058n71CNV Loss21882294
    nsv914523CNV Loss21882294
    dgv5051n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602399    OMIM disorders: --

    UniProtKB/Swiss-Prot: MK12_HUMAN, P53778
  • Note=MAPK is overexpressed in highly metastatic breast cancer cell lines and its expression is
    preferentially associated with basal-like and metastatic phenotypes of breast tumor samples

  • 20/26 diseases for MAPK12 (see all 26):    About MalaCards
    trypanosomiasis    shigellosis    chagas disease    toxoplasmosis
    lateral sclerosis    amyotrophic lateral sclerosis    pertussis    leishmaniasis
    oral squamous cell carcinoma    hypoxia    acute lymphoblastic leukemia    lymphoblastic leukemia
    influenza    hepatitis c    atherosclerosis    squamous cell carcinoma
    breast cancer    alzheimer's disease    parkinson's disease    hepatocellular carcinoma


    MAPK12 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for MAPK12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 18.5 1 9029150 (1)
    necrosis 0 1 9029150 (1)
    inflammation 0 2 17482683 (1), 14694199 (1)
    breast cancer 0 5 16885352 (2), 17483331 (2), 19818165 (1)
    tumors 0 3 17850438 (2), 17483331 (1)
    cancer 0 1 16215677 (1)

    Genetic Association Database (GAD): MAPK12
    Human Genome Epidemiology (HuGE) Navigator: MAPK12 (3 documents)

    Export disorders for MAPK12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK12 gene, integrated from 9 sources (see all 180):
    (articles sorted by number of sources associating them with MAPK12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human stress-activated protein kinase-3 gene (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization. (PubMed id 9169156)1, 2, 3, 9 Goedert M.... Clegg S. (1997)
    2. Cardiac expression and subcellular localization of the p38 mitogen- activated protein kinase member, stress-activated protein kinase-3 (SAPK3). (PubMed id 11991731)1, 2, 9 Court N.W.... Bogoyevitch M.A. (2002)
    3. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. (PubMed id 10848581)1, 2, 9 Wang X....Han J. (2000)
    4. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. (PubMed id 8633070)1, 2, 9 Lechner C.... Ullrich A. (1996)
    5. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. (PubMed id 10212242)1, 2, 9 Hasegawa M.... Goedert M. (1999)
    6. Loss of p38gamma MAPK induces pleiotropic mitotic def ects and massive cell death. (PubMed id 21172807)1, 2 Kukkonen-Macchi A....Kallio M.J. (2011)
    7. p38gamma mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase- 1 inhibition in breast cancer. (PubMed id 21532888)1, 2 Meng F....Wu G. (2011)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. (PubMed id 20605917)1, 2 Sabio G....Cuenda A. (2010)
    10. p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. (PubMed id 17724032)1, 2 Qi X....Chen G. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6300 HGNC: 6874 AceView: MAPK12 Ensembl:ENSG00000188130 euGenes: HUgn6300
    ECgene: MAPK12 Kegg: 6300 H-InvDB: MAPK12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAPK12 gene:
    Search GeneIP for patents involving MAPK12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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