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MAPK11 Gene

protein-coding   GIFtS: 73
GCID: GC22M050702

Mitogen-Activated Protein Kinase 11


(Previous symbol: PRKM11)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mitogen-Activated Protein Kinase 111 2     P38BETA22
PRKM111 2 3     Mitogen-Activated Protein Kinase P38-22
Mitogen-Activated Protein Kinase P38 Beta2 3     p38Beta2
SAPK22 3     Stress-Activated Protein Kinase-22
SAPK2B2 3     Stress-Activated Protein Kinase-2b2
MAP Kinase 112 3     SAPK2b3
MAP Kinase P38 Beta2 3     MAPK 113
p38-22 3     p38b3
EC 2.7.11.243 8     Stress-Activated Protein Kinase 2b3
P38B2     EC 2.7.118

External Ids:    HGNC: 68731   Entrez Gene: 56002   Ensembl: ENSG000001853867   OMIM: 6028985   UniProtKB: Q157593   
ORGUL members:         

Export aliases for MAPK11 gene to outside databases

Previous GC identifers: GC22M047253 GC22M048884 GC22M048874 GC22M049004 GC22M049044 GC22M033599


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK11 Gene:
This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical
signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional
regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental
stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for MAPK11 Gene:
MAPK11 (mitogen-activated protein kinase 11) is a protein-coding gene. Diseases associated with MAPK11 include shigellosis, and trypanosomiasis. GO annotations related to this gene include MAP kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is MAPK9.

UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been
estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with
those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and
further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate
transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also
phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in
the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing
chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets,
MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional
level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the
elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs,
regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK
pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced
apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of
transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs
phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for
ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR
signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be
translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes
such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many
transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical
examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging
as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of
several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent
enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This
phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for
increased NF-kappa-B recruitment

summary for MAPK11 Gene:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011526.8  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK11 gene promoter:
         CRE-BP1   p53   ATF-2   NRSF form 1   STAT3   NF-kappaB1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPK11 promoter sequence
   Search Chromatin IP Primers for MAPK11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

MAPK11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK11 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050702:  view genomic region     (about GC identifiers)

Start:
50,702,142 bp from pter      End:
50,709,196 bp from pter
Size:
7,055 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 11  
Size: 364 amino acids; 41357 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with HDAC3 and DUSP16
3 PDB 3D structures from and Proteopedia for MAPK11:
3GC8 (3D)        3GC9 (3D)        3GP0 (3D)    
Secondary accessions: B0LPG1 O00284 O15472 Q2XNF2

Explore the universe of human proteins at neXtProt for MAPK11: NX_Q15759

Explore proteomics data for MAPK11 at MOPED

Post-translational modifications: 

  • Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6, which activates the
    enzyme1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPK11 (Q15759) (see all 18)
     ILDFGLA  LDFGLAR  LKYIHSA  LLDVFTP 


    See MAPK11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002742.3  
    ENSEMBL proteins: 
     ENSP00000333685   ENSP00000379113   ENSP00000409136   ENSP00000406921  
    Reactome Protein details: Q15759

    MAPK11 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAPK11 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAPK11
    OriGene Protein Over-expression Lysate for MAPK11
    OriGene MassSpec for MAPK11
    OriGene Custom Protein Services for MAPK11
    GenScript Custom Purified and Recombinant Proteins Services for MAPK11
    Novus Biologicals MAPK11 Proteins
    Novus Biologicals MAPK11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAPK11
    Cloud-Clone Corp. Proteins for MAPK11

    MAPK11 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK11
    R&D Systems Antibodies for MAPK11 (p38 beta)
    Cell Signaling Technology (CST) Antibodies for MAPK11  (P38B)
    OriGene Antibodies for MAPK11
    OriGene Custom Antibody Services for MAPK11
    Novus Biologicals MAPK11 Antibodies
    Abcam antibodies for MAPK11
    Cloud-Clone Corp. Antibodies for MAPK11
    ThermoFisher Antibodies for MAPK11
    LSBio Antibodies in human, mouse, rat for MAPK11

    MAPK11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAPK11
    R&D Systems ELISAs for MAPK11 (p38 beta)         (see all)
    GenScript Custom Assay Services for MAPK11
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK11 (P38B)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK11
    Cloud-Clone Corp. CLIAs for MAPK11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 11
    p38 subfamily
    Mitogen-activated protein kinases

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q15759

    ProtoNet protein and cluster: Q15759

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK11_HUMAN, Q15759
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
    evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
    of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been
    estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with
    those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and
    further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate
    transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also
    phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in
    the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing
    chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets,
    MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional
    level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the
    elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs,
    regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK
    pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced
    apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of
    transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs
    phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for
    ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR
    signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be
    translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes
    such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many
    transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical
    examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging
    as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of
    several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent
    enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This
    phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for
    increased NF-kappa-B recruitment
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on threonine and tyrosine by MAP2K3/MKK3, MAP2K4/MKK4 and
    MAP2K6/MKK6. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 induced by environmental
    stress. HDAC3 interacts directly and selectively with MAPK11 to repress ATF2 transcriptional activity, and
    regulate TNF gene expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related
    compounds

         Genatlas biochemistry entry for MAPK11:
    mitogen-activated protein kinase 11

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004707MAP kinase activity IDA10330143
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI17254968
         
    MAPK11 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAPK11:
     Decreased viability with RAF26  Synthetic lethal with imatinib 

         14 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Mapk11):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  normal  reproductive system  skeleton 

    MAPK11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAPK11: Mapk11tm1Okee Mapk11tm1Jsca Mapk11tm2.1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPK11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK11

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPK11:
    hsa-let-7a-5p (MIRT052537), hsa-mir-124-3p (MIRT022536), hsa-mir-122-5p (MIRT003097)

    Block miRNA regulation of human, mouse, rat MAPK11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK11 (see all 11):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-873 hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidMAPK11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPK11
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK11

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK11 (see all 7)
    OriGene ORF clones in mouse, rat for MAPK11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK11 (NM_002751)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK11

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK11
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MK11_HUMAN, Q15759: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0016020membrane ----

    MAPK11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK11 About   (see all 125)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Fc epsilon RI signaling pathway0.41
    VEGF - VEGF R2 Signaling Pathways0.35
    2MAPK targets/ Nuclear events mediated by MAP kinases
    ERK/MAPK targets0.88
    MAP kinase activation in TLR cascade0.61
    Nuclear Events (kinase and transcription factor activation)0.88
    MAP Kinase Signaling0.31
    MAPK targets/ Nuclear events mediated by MAP kinases0.80
    activated TAK1 mediates p38 MAPK activation0.00
    3Toll Comparative Pathway
    Toll Comparative Pathway0.61
    IL-1 Pathway0.39
    TLR-TRIF Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    4Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    5Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for MAPK11 (see all 8)
        Inflammasome Activation Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK11 (see all 90)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK11
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK11
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MAPK11 (see all 27)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway

    Selected BioSystems Pathways for MAPK11 (see all 22)
        Insulin Signaling
    Parkinsons Disease Pathway
    Physiological and Pathological Hypertrophy of the Heart
    IL-4 signaling Pathway
    Toll-like receptor signaling pathway

    Selected Reactome Pathways for MAPK11 (see all 10)
        Activation of PPARGC1A (PGC-1alpha) by phosphorylation
    KSRP destabilizes mRNA
    DSCAM interactions
    Oxidative Stress Induced Senescence
    activated TAK1 mediates p38 MAPK activation

    1 PharmGKB Pathway for MAPK11
        VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for MAPK11) (see all 33):
        MAPK signaling pathway
    Rap1 signaling pathway
    FoxO signaling pathway
    Adrenergic signaling in cardiomyocytes
    VEGF signaling pathway


    MAPK11 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK11: 
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK11 (Q157591, 2, 3 ENSP000003336854) via UniProtKB, MINT, STRING, and/or I2D (see all 337)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR3DP054232, 3, ENSP000003030884MINT-8260537 I2D: score=2 STRING: ENSP00000303088
    TP53P046371, 3, ENSP000002693054EBI-298304,EBI-366083 I2D: score=2 STRING: ENSP00000269305
    ZNHIT1O432571, 3, ENSP000003045934EBI-298304,EBI-347522 I2D: score=1 STRING: ENSP00000304593
    CPNE6O957412, 3MINT-8260515 I2D: score=2 
    ATF2P153362, 3, ENSP000002641104MINT-4789511 I2D: score=5 STRING: ENSP00000264110
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    MAPK11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    10 ApexBio Compounds for MAPK11     About this table
    CompoundAction CAS #
    BIRB 796 (Doramapimod)Cell pemeable p38 MAP Kinase Inhibitor [285983-48-4]
    LY2228820Potent and ATP-competitive p38 MAP kinase inhibitor[862507-23-1]
    PD 169316p38 MAPK inhibitor[152121-53-4]
    PH-797804Potent and selective p38 MAP kinase inhibitor[586379-66-0]
    SB 203580Cell permeable, reversible, and ATP-competitive p38 MAP kinase inhibitor[152121-47-6]
    SB202190 (FHPI)highly selective, potent and cell-permeable inhibitor of p38 MAP kinase[152121-30-7]
    Skepinone-Lselective p38 mitogen-activated protein kinase inhibitor[1221485-83-1]
    TAK-715inhibitor of p38 MAPK[303162-79-0]
    VX-702P38 MAPK inhibitor[479543-46-9]
    VX-745highly potent and selective p38alpha inhibitor[209410-46-8]

    Compounds for MAPK11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 239063 Potent, selective p38 MAPK inhibitor; orally active [193551-21-2]
    SB 202190 Potent, selective inhibitor of p38 MAPK [152121-30-7]
    SB 203580 hydrochlorideSelective inhibitor of p38 MAPK; water-soluble[152121-47-6]
    SB 203580Selective inhibitor of p38 MAPK[152121-47-6]
    SCIO 469 hydrochlorideSelective p38 MAPK inhibitor[309913-83-5]

    3 HMDB Compounds for MAPK11    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for MAPK11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Regorafenib-- 755037-03-7targetinhibitor--

    9 Novoseek inferred chemical compound relationships for MAPK11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 83.9 10 10585868 (1), 16151644 (1), 17481747 (1), 20053787 (1) (see all 8)
    wortmannin 46.4 4 10585868 (1), 9252422 (1), 9873045 (1)
    arsenite 37.9 3 9252422 (1), 9873045 (1), 12475989 (1)
    phosphatidylinositol 23.8 1 9873045 (1)
    ly294002 23.4 2 10585868 (1)
    oxygen 0 2 14997018 (1), 18323531 (1)
    glucose 0 13 9873045 (4), 9252422 (3), 10585868 (2), 15947002 (2) (see all 5)
    calcium 0 1 9412491 (1)
    serine 0 2 9199504 (1)



    MAPK11 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for MAPK11 gene: 
    NM_002751.6  

    Unigene Cluster for MAPK11:

    Mitogen-activated protein kinase 11
    Hs.57732  [show with all ESTs]
    Unigene Representative Sequence: BC027933
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330651(uc003bkr.3) ENST00000395764(uc010hay.1) ENST00000417877
    ENST00000495277 ENST00000449719(uc011art.1 uc010haz.2)

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    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-873 hsa-let-7b
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    Additional mRNA sequence: 

    AF001008.1 AF001174.1 AF031135.1 AK291845.1 AK299745.1 AK308969.1 AK309046.1 BC027933.1 
    CR456514.1 Y14440.1 

    7 DOTS entries:

    DT.441095  DT.100021341  DT.100767888  DT.100649627  DT.312511  DT.95131967  DT.100721291 

    Selected AceView cDNA sequences (see all 61):

    BM857051 CR615085 NM_002751 CR592517 CR600695 CR605909 NM_138993 BC027933 
    CR624704 AL157630 BQ894152 AF031135 AF001008 BG820782 AW511197 BM553124 
    BI837126 AF001174 AA302830 BX411138 BX402786 CR456514 Y14440 U92268 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPK11 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14
    SP1:                    -                                                     -     -                       -     -         
    SP2:                    -                                                     -     -                                       
    SP3:                    -                                                                                                   
    SP4:                                                                                                                        
    SP5:        -           -     -                                                                                             


    ECgene alternative splicing isoforms for MAPK11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAPK11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGGGGCT
    MAPK11 Expression
    About this image


    MAPK11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
     
     Liver (Hepatobiliary System)
             Liver Bud
    MAPK11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.57732

    UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759
    Tissue specificity: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal
    muscle, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK11: 
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK11 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk111 , 5 mitogen-activated protein kinase 111, 5 88.83(n)1
    97.25(a)1
      15 (44.66 cM)5
    190941  NM_011161.51  NP_035291.41 
     891424865 
    chicken
    (Gallus gallus)
    Aves MAPK111 mitogen-activated protein kinase 11 71.04(n)
    84.08(a)
      417739  NM_001006227.1  NP_001006227.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK116
    mitogen-activated protein kinase 11
    84(a)
    1 ↔ 1
    5(64268774-64319908)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mapk111 mitogen-activated protein kinase 11 69.53(n)
    82.27(a)
      100101766  NM_001105284.1  NP_001098754.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapk111 mitogen-activated protein kinase 11 71.04(n)
    82.96(a)
      415185  NM_001002095.1  NP_001002095.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p38b3 regulation of BMP signaling pathway
    protein serine/threonine more
    67(a)
    (best of 3)
      34D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea pmk-13 ser/thr kinases 64(a)
    (best of 6)
      IV(8148976-8149980)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HOG16
    Mitogen-activated protein kinase involved in osmor...
    39(a)
    1 → many
    XII(371620-372927) YLR113W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MPK101 MPK10 52.02(n)
    46.97(a)
      825148  NM_115841.1  NP_191538.1 


    ENSEMBL Gene Tree for MAPK11 (if available)
    TreeFam Gene Tree for MAPK11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK11 gene
    MAPK92  MAPK122  MAPK132  MAPK142  MAPK82  MAPK102  
    Selected SIMAP similar genes for MAPK11 using alignment to 4 protein entries:     MK11_HUMAN (see all proteins) (see all similar genes):
    MAPK14    MAPK12    MAPK13    DKFZp686M02159    MAPK10    MAPK8
    MAPK9    MAPK7    DKFZp686O0215    MAPK3    NLK    MAPK1
    MAPK4    CDK20    MAPK15    CDKL4    CDKL2    CDK3

    MAPK11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPK11 (see all 1452)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0422644
    A lung neuroendocrine carcinoma sample4--see VAR_0422642 A V mis40--------
    rs349856801,2
    C,F--34644453(-) CCACCC/TCCGCC 1 -- ds50017Minor allele frequency- T:0.01NS 280
    rs1812455041,2
    --34644638(+) ATGGCC/TGCTGG 1 -- ds50010--------
    rs617606071,2
    C,F--34644711(-) CGTGGG/AGGGAG 1 -- ds50015Minor allele frequency- A:0.06NS CSA WA 215
    rs617606061,2
    C,F--34644715(-) TGGGCG/TTGGGG 1 -- ds50012Minor allele frequency- T:0.01NS 94
    rs1867544101,2
    C--34644744(+) GCACCC/TGGGCC 1 -- ds50010--------
    rs1891087521,2
    --34644777(+) CCAAGG/TGAGAG 1 -- ut310--------
    rs1461980011,2
    C--34644913(+) GTCCCA/GTCTCC 1 -- ut310--------
    rs1388894531,2
    C--34644940(+) CTCCAA/TCCTGG 1 -- ut310--------
    rs617606051,2
    C--34644965(-) TGTGGG/ATCAGT 1 -- ut312Minor allele frequency- A:0.01NS 92

    HapMap Linkage Disequilibrium report for MAPK11 (50702142 - 50709196 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAPK11 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724762CNV Deletion23290073
    nsv471223CNV Loss18288195
    nsv915495CNV Loss21882294
    dgv5060n71CNV Loss21882294
    nsv914517CNV Loss21882294
    dgv5055n71CNV Loss21882294
    dgv5059n71CNV Loss21882294
    nsv914525CNV Loss21882294
    nsv914524CNV Loss21882294
    dgv5058n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602898    OMIM disorders: --

    Selected diseases for MAPK11 (see all 27):    
    About MalaCards
    shigellosis    trypanosomiasis    toxoplasmosis    chagas disease
    pertussis    leishmaniasis    duodenitis    pheochromocytoma
    lateral sclerosis    amyotrophic lateral sclerosis    nasopharyngitis    ischemia
    non-hodgkin lymphoma    hodgkin's lymphoma    influenza    parkinson's disease
    retinoblastoma    hepatitis c    b-cell lymphomas    tuberculosis


    MAPK11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for MAPK11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 35 2 9252422 (1), 10988297 (1)
    necrosis 18.6 1 9029150 (1)
    inflammation 8.21 4 20134354 (1), 17482683 (1), 10207622 (1), 14694199 (1)
    ischemia 0 1 12425942 (1)
    breast cancer 0 1 12475989 (1)

    Genetic Association Database (GAD): MAPK11
    Human Genome Epidemiology (HuGE) Navigator: MAPK11 (6 documents)

    Export disorders for MAPK11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK11 gene, integrated from 10 sources (see all 162):
    (articles sorted by number of sources associating them with MAPK11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PubMed id 9218798)1, 2, 3, 9 Goedert M.... Cohen P. (EMBO J. 1997)
    2. p38-2, a novel mitogen-activated protein kinase with distinct properties. (PubMed id 9235954)1, 2, 9 Stein B....Barbosa M.S. (J. Biol. Chem. 1997)
    3. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. (PubMed id 9207191)1, 2, 9 Kumar S.... Young P.R. (Biochem. Biophys. Res. Commun. 1997)
    4. Characterization of the structure and function of a new mitogen- activated protein kinase (p38beta). (PubMed id 8663524)1, 2, 9 Jiang Y.... Han J. (J. Biol. Chem. 1996)
    5. The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha. (PubMed id 19622861)1, 2, 9 Patel S.B.... Scapin G. (Acta Crystallogr. D 2009)
    6. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. (PubMed id 10330143)1, 2, 9 Yang S.-H.... Sharrocks A.D. (Mol. Cell. Biol. 1999)
    7. Mechanisms and functions of p38 MAPK signalling. (PubMed id 20626350)1, 2 Cuadrado A. and Nebreda A.R. (Biochem. J. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    10. Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression. (PubMed id 15356147)1, 2 Mahlknecht U.... Herbein G. (J. Immunol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5600 HGNC: 6873 AceView: MAPK11 Ensembl:ENSG00000185386 euGenes: HUgn5600
    ECgene: MAPK11 Kegg: 5600 H-InvDB: MAPK11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAPK11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK11 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mapk11/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPK11 gene:
    Search GeneIP for patents involving MAPK11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     ELISAs for MAPK11
     CLIAs for MAPK11



     Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK11
     SwitchGear 3'UTR luciferase reporter plasmids for MAPK11
     SwitchGear Promoter luciferase reporter plasmids for MAPK11
     ThermoFisher Antibodies for MAPK11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK11
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK11
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPK11
     LSBio Antibodies in human, mouse, rat for MAPK11
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for MAPK11
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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