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Aliases for MAPK11 Gene

Aliases for MAPK11 Gene

  • Mitogen-Activated Protein Kinase 11 2 3 5
  • Mitogen-Activated Protein Kinase P38 Beta 3 4
  • MAP Kinase P38 Beta 3 4
  • MAP Kinase 11 3 4
  • EC 2.7.11.24 4 63
  • PRKM11 3 4
  • SAPK2B 3 4
  • SAPK2 3 4
  • P38-2 3 4
  • P38B 3 4
  • Mitogen-Activated Protein Kinase P38-2 3
  • Stress-Activated Protein Kinase-2b 3
  • Stress-Activated Protein Kinase 2b 4
  • Stress-Activated Protein Kinase-2 3
  • EC 2.7.11 63
  • P38BETA2 3
  • P38Beta 3
  • MAPK 11 4

External Ids for MAPK11 Gene

Previous HGNC Symbols for MAPK11 Gene

  • PRKM11

Previous GeneCards Identifiers for MAPK11 Gene

  • GC22M047253
  • GC22M048884
  • GC22M048874
  • GC22M049004
  • GC22M049044
  • GC22M050702
  • GC22M033599

Summaries for MAPK11 Gene

Entrez Gene Summary for MAPK11 Gene

  • This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for MAPK11 Gene

MAPK11 (Mitogen-Activated Protein Kinase 11) is a Protein Coding gene. Among its related pathways are Gene Expression and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK8.

UniProtKB/Swiss-Prot for MAPK11 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment.

Tocris Summary for MAPK11 Gene

  • MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions.

Gene Wiki entry for MAPK11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK11 Gene

Genomics for MAPK11 Gene

Regulatory Elements for MAPK11 Gene

Promoters for MAPK11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAPK11 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAPK11 Gene

Chromosome:
22
Start:
50,263,713 bp from pter
End:
50,270,767 bp from pter
Size:
7,055 bases
Orientation:
Minus strand

Genomic View for MAPK11 Gene

Genes around MAPK11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK11 Gene

Proteins for MAPK11 Gene

  • Protein details for MAPK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15759-MK11_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 11
    Protein Accession:
    Q15759
    Secondary Accessions:
    • A8K730
    • B0LPG1
    • B7Z630
    • E7ETQ1
    • L7RT27
    • O00284
    • O15472
    • Q2XNF2

    Protein attributes for MAPK11 Gene

    Size:
    364 amino acids
    Molecular mass:
    41357 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with HDAC3 and DUSP16.

    Three dimensional structures from OCA and Proteopedia for MAPK11 Gene

    Alternative splice isoforms for MAPK11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK11 Gene

Proteomics data for MAPK11 Gene at MOPED

Post-translational modifications for MAPK11 Gene

  • Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6, which activates the enzyme.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPK11 (P38B)
  • Cloud-Clone Corp. Antibodies for MAPK11

Domains & Families for MAPK11 Gene

Suggested Antigen Peptide Sequences for MAPK11 Gene

Graphical View of Domain Structure for InterPro Entry

Q15759

UniProtKB/Swiss-Prot:

MK11_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK11: view

Function for MAPK11 Gene

Molecular function for MAPK11 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase 11
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on threonine and tyrosine by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 induced by environmental stress. HDAC3 interacts directly and selectively with MAPK11 to repress ATF2 transcriptional activity, and regulate TNF gene expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related compounds.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment.

Enzyme Numbers (IUBMB) for MAPK11 Gene

genes like me logo Genes that share phenotypes with MAPK11: view

Animal Models for MAPK11 Gene

MGI Knock Outs for MAPK11:

Animal Model Products

CRISPR Products

miRNA for MAPK11 Gene

miRTarBase miRNAs that target MAPK11

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAPK11 Gene

Localization for MAPK11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK11 Gene COMPARTMENTS Subcellular localization image for MAPK11 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 3
cytoskeleton 1
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for MAPK11 Gene

Pathways & Interactions for MAPK11 Gene

SuperPathways for MAPK11 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 IL-2 Pathway
3 Interleukin-3, 5 and GM-CSF signaling
4 4-1BB Pathway
5 GPCR Pathway
genes like me logo Genes that share pathways with MAPK11: view

SIGNOR curated interactions for MAPK11 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for MAPK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MAPK11: view

Drugs & Compounds for MAPK11 Gene

(26) Drugs for MAPK11 Gene - From: HMDB, ApexBio, DGIdb, Novoseek, DrugBank, FDA Approved Drugs, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
regorafenib Approved Pharma Target, inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Stivarga Approved February 2013/ Approved September 2012 Pharma 0
Adenosine triphosphate Approved Nutra 0
VX-702 Investigational Pharma inhibitor P38α MAPK inhibitor,highly selective and ATP-competitive 0
KC706 Investigational Pharma inhibitor, Target 0

(9) Additional Compounds for MAPK11 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
SB 202190
152121-30-7
SB 203580 hydrochloride
869185-85-3
SB 239063
193551-21-2
SKF 86002 dihydrochloride
116339-68-5

(5) Tocris Compounds for MAPK11 Gene

Compound Action Cas Number
SB 202190 Potent, selective inhibitor of p38 MAPK 152121-30-7
SB 203580 Selective inhibitor of p38 MAPK 152121-47-6
SB 203580 hydrochloride Selective inhibitor of p38 MAPK; water-soluble 869185-85-3
SB 239063 Potent, selective p38 MAPK inhibitor; orally active 193551-21-2
SKF 86002 dihydrochloride p38 MAPK inhibitor; anti-inflammatory agent 116339-68-5

(9) ApexBio Compounds for MAPK11 Gene

Compound Action Cas Number
BIRB 796 (Doramapimod) P38 MAPK inhibitor,cell permeable and highly selective 285983-48-4
Losmapimod 585543-15-3
LY2228820 P38 MAP kinase inhibitor 862507-23-1
PH-797804 P38 MAP kinase inhibitor, potent and selective 586379-66-0
SB202190 (FHPI) P38 MAPK inhibitor 152121-30-7
Skepinone-L P38-MAPK inhibitor,potent and selective 1221485-83-1
TAK-715 p38 MAPK inhibitor 303162-79-0
VX-702 P38α MAPK inhibitor,highly selective and ATP-competitive 479543-46-9
VX-745 P38α inhibitor,highly potent and selective 209410-46-8
genes like me logo Genes that share compounds with MAPK11: view

Drug Products

Transcripts for MAPK11 Gene

Unigene Clusters for MAPK11 Gene

Mitogen-activated protein kinase 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14
SP1: - - - - -
SP2: - - -
SP3: -
SP4:
SP5: - - -
SP6:

Relevant External Links for MAPK11 Gene

GeneLoc Exon Structure for
MAPK11
ECgene alternative splicing isoforms for
MAPK11

Expression for MAPK11 Gene

mRNA expression in normal human tissues for MAPK11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAPK11 Gene

This gene is overexpressed in Retina (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAPK11 Gene



SOURCE GeneReport for Unigene cluster for MAPK11 Gene Hs.57732

mRNA Expression by UniProt/SwissProt for MAPK11 Gene

Q15759-MK11_HUMAN
Tissue specificity: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with MAPK11: view

Protein tissue co-expression partners for MAPK11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAPK11 Gene

Orthologs for MAPK11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPK11 35
  • 90.98 (n)
  • 96.3 (a)
MAPK11 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK11 35
  • 90.27 (n)
  • 95.14 (a)
mouse
(Mus musculus)
Mammalia Mapk11 35
  • 88.83 (n)
  • 97.25 (a)
Mapk11 16
Mapk11 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk11 35
  • 88.64 (n)
  • 96.7 (a)
oppossum
(Monodelphis domestica)
Mammalia MAPK11 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK11 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAPK11 35
  • 71.04 (n)
  • 84.08 (a)
MAPK11 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK11 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk11 35
  • 69.53 (n)
  • 82.27 (a)
zebrafish
(Danio rerio)
Actinopterygii mapk11 35
  • 71.04 (n)
  • 82.96 (a)
mapk11 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mpk2 37
  • 65 (a)
p38b 37
  • 67 (a)
p38c 37
  • 42 (a)
Mpk2 36
  • 63 (a)
ManyToMany
p38b 36
  • 65 (a)
ManyToMany
p38c 36
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C49C3.10a 37
  • 28 (a)
C49C3.10b 37
  • 29 (a)
F09C12.2 37
  • 38 (a)
pmk-1 37
  • 64 (a)
pmk-3 37
  • 41 (a)
Y51B9A.9 37
  • 33 (a)
pmk-1 36
  • 59 (a)
ManyToMany
pmk-2 36
  • 48 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOG1 36
  • 39 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MPK10 35
  • 52.02 (n)
  • 46.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for MAPK11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK11 Gene

ENSEMBL:
Gene Tree for MAPK11 (if available)
TreeFam:
Gene Tree for MAPK11 (if available)

Paralogs for MAPK11 Gene

Paralogs for MAPK11 Gene

genes like me logo Genes that share paralogs with MAPK11: view

Variants for MAPK11 Gene

Sequence variations from dbSNP and Humsavar for MAPK11 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs33932986 - 50,265,599(+) CTCCA(C/T)GGAAG nc-transcript-variant, reference, missense
VAR_042264 A lung neuroendocrine carcinoma sample
rs1003969 -- 50,271,558(+) CCCCA(C/T)TGGAA upstream-variant-2KB
rs2076139 -- 50,266,232(+) TGTTC(C/T)GAGGA nc-transcript-variant, reference, synonymous-codon
rs2076140 -- 50,268,117(+) TACCC(A/C)CTCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAPK11 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
dgv781n67 CNV Gain 20364138
dgv5055n71 CNV Loss 21882294
nsv914515 CNV Gain 21882294
nsv471223 CNV Loss 18288195
nsv914517 CNV Loss 21882294
dgv5058n71 CNV Loss 21882294
nsv914523 CNV Loss 21882294
nsv914524 CNV Loss 21882294
nsv914525 CNV Loss 21882294
dgv5059n71 CNV Loss 21882294
dgv5060n71 CNV Loss 21882294
esv2724762 CNV Deletion 23290073
dgv782n67 CNV Gain 20364138

Variation tolerance for MAPK11 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK11 Gene

HapMap Linkage Disequilibrium report
MAPK11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK11 Gene

Disorders for MAPK11 Gene

Relevant External Links for MAPK11

Genetic Association Database (GAD)
MAPK11
Human Genome Epidemiology (HuGE) Navigator
MAPK11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK11

No disorders were found for MAPK11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAPK11 Gene

Publications for MAPK11 Gene

  1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PMID: 9218798) Goedert M. … Cohen P. (EMBO J. 1997) 2 3 4 23 67
  2. Interferon-alpha induces the growth inhibition of human T-cell leukaemia line Jurkat through p38alpha and p38beta. (PMID: 20053787) Lee W.H. … Huang H.M. (J. Biochem. 2010) 3 23
  3. Activin A induction of erythroid differentiation through MKK6-p38alpha/p38beta pathway is inhibited by follistatin. (PMID: 20162623) Huang H.M. … Chung M.H. (J. Cell. Physiol. 2010) 3 23
  4. Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase. (PMID: 19082897) Si H. … Liu D. (Apoptosis 2009) 3 23
  5. The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha. (PMID: 19622861) Patel S.B. … Scapin G. (Acta Crystallogr. D 2009) 3 23

Products for MAPK11 Gene

Sources for MAPK11 Gene

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