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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK11 Gene

protein-coding   GIFtS: 73
GCID: GC22M050702

Mitogen-Activated Protein Kinase 11


(Previous symbol: PRKM11)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase 111 2     P38B2
PRKM111 2 3     P38BETA22
Mitogen-Activated Protein Kinase P38 Beta2 3     Mitogen-Activated Protein Kinase P38-22
Stress-Activated Protein Kinase 2b2 3     p38Beta2
SAPK22 3     Stress-Activated Protein Kinase 22
SAPK2B2 3     Stress-Activated Protein Kinase-22
MAP Kinase 112 3     Stress-Activated Protein Kinase-2b2
MAP Kinase P38 Beta2 3     SAPK2b3
MAPK 112 3     p38b3
p38-22 3     EC 2.7.118
EC 2.7.11.243 8     

External Ids:    HGNC: 68731   Entrez Gene: 56002   Ensembl: ENSG000001853867   OMIM: 6028985   UniProtKB: Q157593   

Export aliases for MAPK11 gene to outside databases

Previous GC identifers: GC22M047253 GC22M048884 GC22M048874 GC22M049004 GC22M049044 GC22M033599


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPK11 Gene:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP
kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is
activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor
ATF2/CREB2 has been shown to be a substrate of this kinase. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPK11 Gene: 
MAPK11 (mitogen-activated protein kinase 11) is a protein-coding gene. Diseases associated with MAPK11 include trypanosomiasis, and shigellosis, and among its related super-pathways are MAPK Cascade and Development FGF-family signaling. GO annotations related to this gene include MAP kinase activity and protein serine/threonine kinase activity. An important paralog of this gene is MAPK9.

UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been
estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with
those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and
further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate
transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also
phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in
the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing
chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets,
MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional
level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the
elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs,
regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK
pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced
apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of
transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs
phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for
ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR
signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be
translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes
such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many
transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical
examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging
as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of
several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent
enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This
phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for
increased NF-kappa-B recruitment

summary for MAPK11 Gene:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011526.7  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK11 gene promoter:
         CRE-BP1   p53   ATF-2   NRSF form 1   STAT3   NF-kappaB1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAPK11 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

MAPK11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK11 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050702:  view genomic region     (about GC identifiers)

Start:
50,702,142 bp from pter      End:
50,709,196 bp from pter
Size:
7,055 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 11  
Size: 364 amino acids; 41357 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with HDAC3 and DUSP16
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
3 PDB 3D structures from and Proteopedia for MAPK11:
3GC8 (3D)        3GC9 (3D)        3GP0 (3D)    
Secondary accessions: B0LPG1 O00284 O15472 Q2XNF2

Explore the universe of human proteins at neXtProt for MAPK11: NX_Q15759

Explore proteomics data for MAPK11 at MOPED 

Post-translational modifications:

  • UniProtKB: Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6, which activates the
    enzyme
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15759

  • 4/18 DME Specific Peptides for MAPK11 (Q15759) (see all 18)
     ILDFGLA  LDFGLAR  LKYIHSA  LLDVFTP 

    MAPK11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAPK11 Protein Expression
    REFSEQ proteins: NP_002742.3  
    ENSEMBL proteins: 
     ENSP00000333685   ENSP00000379113   ENSP00000409136   ENSP00000406921  
    Reactome Protein details: Q15759
    Human Recombinant Protein Products for MAPK11: 
    EMD Millipore Purified and/or Recombinant MAPK11 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAPK11
    OriGene Protein Over-expression Lysate for MAPK11
    OriGene MassSpec for MAPK11 
    OriGene Custom Protein Services for MAPK11
    GenScript Custom Purified and Recombinant Proteins Services for MAPK11
    Novus Biologicals MAPK11 Proteins
    Novus Biologicals MAPK11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MAPK11
    Cloud-Clone Corp. Proteins for MAPK11 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0016020membrane ----

    MAPK11 for ontologies           About GeneDecksing



    MAPK11 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK11
    R&D Systems Antibodies for MAPK11 (p38 beta)
    Cell Signaling Technology (CST) Antibodies for MAPK11  (P38B)
    OriGene Antibodies for MAPK11
    OriGene Custom Antibody Services for MAPK11
    GenScript Custom Superior Antibodies Services for MAPK11
    Novus Biologicals MAPK11 Antibodies
    Abcam antibodies for MAPK11
    Cloud-Clone Corp. Antibodies for MAPK11 
    ThermoFisher Antibodies for MAPK11
    LSBio Antibodies in human, mouse, rat for MAPK11 

    Assay Products for MAPK11: 
    EMD Millipore Kits and Assays for the Analysis of MAPK11
    OriGene Custom Assay Services for MAPK11
    R&D Systems ELISAs for MAPK11 (p38 beta)         (see all)
    GenScript Custom Assay Services for MAPK11
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK11 (P38B)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK11 
    Cloud-Clone Corp. CLIAs for MAPK11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 11 
    p38 subfamily
    Mitogen-activated protein kinases

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q15759

    ProtoNet protein and cluster: Q15759

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    MAPK11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK11_HUMAN, Q15759
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses
    evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation
    of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been
    estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with
    those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and
    further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate
    transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also
    phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in
    the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing
    chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets,
    MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional
    level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the
    elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs,
    regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK
    pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced
    apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of
    transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs
    phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for
    ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR
    signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be
    translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes
    such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many
    transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical
    examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging
    as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of
    several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent
    enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This
    phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for
    increased NF-kappa-B recruitment
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on threonine and tyrosine by MAP2K3/MKK3, MAP2K4/MKK4 and
    MAP2K6/MKK6. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 induced by environmental
    stress. HDAC3 interacts directly and selectively with MAPK11 to repress ATF2 transcriptional activity, and
    regulate TNF gene expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related
    compounds

         Genatlas biochemistry entry for MAPK11:
    mitogen-activated protein kinase 11

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004707MAP kinase activity IDA10330143
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI17254968
         
    MAPK11 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAPK11:
     Decreased viability with RAF26  Synthetic lethal with imatinib 

         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Mapk11):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  normal  reproductive system  skeleton 

    MAPK11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAPK11: Mapk11tm1Okee Mapk11tm1Jsca

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAPK11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAPK11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK11 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPK11:
    hsa-mir-122 (MIRT003097)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK11
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK11 (see all 11):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-873 hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidMAPK11 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAPK11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK11
    Sirion Biotech Customized adenovirus for overexpression of MAPK11

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAPK11 (see all 8)
    OriGene ORF clones in mouse, rat for MAPK11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAPK11 (NM_002751)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK11
    Sirion Biotech Customized lentivirus for stable overexpression of MAPK11 
                         Customized lentivirus expression plasmids for stable overexpression of MAPK11 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK11
    Search LifeMap BioReagents cell lines for MAPK11
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAPK11 About   (see all 128)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1G-protein signaling Ras family GTPases in kinase cascades (scheme)
    G-protein signaling Ras family GTPases in kinase cascades (scheme)0.44
    Activation of the AP-1 family of transcription factors0.33
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Rapid glucocorticoid signaling0.31
    2Development FGF-family signaling
    Development FGF-family signaling0.63
    Development Flt3 signaling0.45
    Development FGFR signaling pathway0.50
    FGF Pathway0.38
    3Toll Comparative Pathway
    Toll Comparative Pathway0.61
    IL-1 Pathway0.39
    TLR-TRIF Pathway0.61
    iNOS Signaling0.34
    Immune response MIF in innate immunity response0.46
    4Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.69
    5Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    VEGF signaling pathway0.39
    Fc epsilon RI signaling pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/25 EMD Millipore Pathways for MAPK11 (see all 25)
        Development A1 receptor signaling
    Immune response MIF in innate immunity response
    G-protein signaling G-Protein alpha-12 signaling pathway
    Development TGF-beta receptor signaling
    Immune response CCR3 signaling in eosinophils

    5/7 R&D Systems Pathways for MAPK11 (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/90 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK11 (see all 90)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK11
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK11
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    5/27 GeneGo (Thomson Reuters) Pathways for MAPK11 (see all 27)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway

    5/20 BioSystems Pathways for MAPK11 (see all 20)
        Insulin Signaling
    Parkinsons Disease Pathway
    IL-4 signaling Pathway
    Toll-like receptor signaling pathway
    Plasma membrane estrogen receptor signaling

    5/44        Reactome Pathways for MAPK11 (see all 44)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    p38MAPK events
    Toll Like Receptor 3 (TLR3) Cascade
    MyD88-independent cascade

    1 PharmGKB Pathway for MAPK11
        VEGF Signaling Pathway

    5/29         Kegg Pathways  (Kegg details for MAPK11) (see all 29):
        MAPK signaling pathway
    VEGF signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway


    MAPK11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/180 Interacting proteins for MAPK11 (Q157591, 2, 3 ENSP000003336854) via UniProtKB, MINT, STRING, and/or I2D (see all 180)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C9orf78Q9NZ632, 3, ENSP000003615244MINT-8260504 I2D: score=2 STRING: ENSP00000361524
    POLR3DP054232, 3, ENSP000003030884MINT-8260537 I2D: score=2 STRING: ENSP00000303088
    TP53P046371, 3, ENSP000002693054EBI-298304,EBI-366083 I2D: score=2 STRING: ENSP00000269305
    CPNE6O957412, 3MINT-8260515 I2D: score=2 
    ATF2P153362, 3, ENSP000002641104MINT-4789511 I2D: score=5 STRING: ENSP00000264110
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    MAPK11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK11 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK11:
    Small Molecule - inhibitor
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    Compounds for MAPK11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 239063 Potent, selective p38 MAPK inhibitor; orally active [193551-21-2]
    SB 202190 Potent, selective inhibitor of p38 MAPK [152121-30-7]
    SB 203580 hydrochlorideSelective inhibitor of p38 MAPK; water-soluble[152121-47-6]
    SB 203580Selective inhibitor of p38 MAPK[152121-47-6]
    SCIO 469 hydrochlorideSelective p38 MAPK inhibitor[309913-83-5]

    3 HMDB Compounds for MAPK11    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for MAPK11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Regorafenib-- 755037-03-7targetinhibitor--

    9 Novoseek inferred chemical compound relationships for MAPK11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 83.9 10 10585868 (1), 16151644 (1), 17481747 (1), 20053787 (1) (see all 8)
    wortmannin 46.4 4 10585868 (1), 9252422 (1), 9873045 (1)
    arsenite 37.9 3 9252422 (1), 9873045 (1), 12475989 (1)
    phosphatidylinositol 23.8 1 9873045 (1)
    ly294002 23.4 2 10585868 (1)
    oxygen 0 2 14997018 (1), 18323531 (1)
    glucose 0 13 9873045 (4), 9252422 (3), 10585868 (2), 15947002 (2) (see all 5)
    calcium 0 1 9412491 (1)
    serine 0 2 9199504 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK11 / MK11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAPK11 gene (2 alternative transcripts): 
    NM_002751.5  NM_138993.2  

    Unigene Cluster for MAPK11:

    Mitogen-activated protein kinase 11
    Hs.57732  [show with all ESTs]
    Unigene Representative Sequence: BC027933
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330651(uc003bkr.3) ENST00000395764(uc010hay.1) ENST00000417877
    ENST00000495277 ENST00000449719(uc011art.1 uc010haz.2)

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    Additional mRNA sequence: 

    AF001008.1 AF001174.1 AF031135.1 AK291845.1 AK299745.1 AK308969.1 AK309046.1 BC027933.1 
    CR456514.1 Y14440.1 

    7 DOTS entries:

    DT.441095  DT.100021341  DT.100767888  DT.100649627  DT.312511  DT.95131967  DT.100721291 

    24/61 AceView cDNA sequences (see all 61):

    AL157630 NM_002751 CR600695 CR615085 CR592517 CR605909 CR624704 BC027933 
    NM_138993 BM857051 BI916012 BX407240 Y14440 BI837126 BX411138 AA310815 
    BX359036 BG977467 BX361670 AF001008 BM543964 BG820782 AF031135 AA302830 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK11 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14
    SP1:                    -                                                     -     -                       -     -         
    SP2:                    -                                                     -     -                                       
    SP3:                    -                                                                                                   
    SP4:                                                                                                                        
    SP5:        -           -     -                                                                                             


    ECgene alternative splicing isoforms for MAPK11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK11 expression in normal human tissues (normalized intensities)      MAPK11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGGGGCT
    MAPK11 Expression
    About this image


    MAPK11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             entorhinal cortex layer ii stellate island cells   
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
     
     Liver (Hepatobiliary System)
             Liver Bud

    See MAPK11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK11

    SOURCE GeneReport for Unigene cluster: Hs.57732

    UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759
    Tissue specificity: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal
    muscle, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK11: 
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK11 gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk111 , 5 mitogen-activated protein kinase 111, 5 88.83(n)1
    97.25(a)1
      15 (44.66 cM)5
    190941  NM_011161.51  NP_035291.41 
     891424865 
    chicken
    (Gallus gallus)
    Aves MAPK111 mitogen-activated protein kinase 11 71.51(n)
    84.64(a)
      417739  NM_001006227.1  NP_001006227.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK116
    Uncharacterized protein
    83(a)
    1 ↔ 1
    5(64268774-64319908)
    zebrafish
    (Danio rerio)
    Actinopterygii mapk111 mitogen-activated protein kinase 11 71.88(n)
    83.52(a)
      415185  NM_001002095.1  NP_001002095.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p38b3 regulation of BMP signaling pathway
    protein serine/threonine more
    67(a)
    (best of 3)
      34D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea pmk-13 ser/thr kinases 64(a)
    (best of 6)
      IV(8148976-8149980)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HOG16
    Mitogen-activated protein kinase involved in osmor...
    38(a)
    1 → many
    XII(371620-372927)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MPK121 mitogen-activated protein kinase 12 52.43(n)
    48.61(a)
      819215  NM_130170.3  NP_182131.2 


    ENSEMBL Gene Tree for MAPK11 (if available)
    TreeFam Gene Tree for MAPK11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK11 gene
    MAPK92  MAPK122  MAPK132  MAPK142  MAPK82  MAPK102  
    18/51 SIMAP similar genes for MAPK11 using alignment to 4 protein entries:     MK11_HUMAN (see all proteins) (see all similar genes):
    MAPK14    MAPK12    MAPK13    DKFZp686M02159    MAPK10    MAPK8
    MAPK9    MAPK7    DKFZp686O0215    MAPK3    NLK    MAPK1
    MAPK4    CDK20    MAPK15    MAPK6    CDKL4    CDKL2

    MAPK11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1452 SNPs in MAPK11 are shown (see all 1452)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0422644
    A lung neuroendocrine carcinoma sample4--see VAR_0422642 A V mis40--------
    rs349856801,2
    C,F--34644453(-) CCACCC/TCCGCC 1 -- ds50017Minor allele frequency- T:0.01NS 280
    rs1812455041,2
    --34644638(+) ATGGCC/TGCTGG 1 -- ds50010--------
    rs617606071,2
    C,F--34644711(-) CGTGGG/AGGGAG 1 -- ds50015Minor allele frequency- A:0.06NS CSA WA 215
    rs617606061,2
    C,F--34644715(-) TGGGCG/TTGGGG 1 -- ds50012Minor allele frequency- T:0.01NS 94
    rs1867544101,2
    C--34644744(+) GCACCC/TGGGCC 1 -- ds50010--------
    rs1891087521,2
    --34644777(+) CCAAGG/TGAGAG 1 -- ut310--------
    rs1461980011,2
    C--34644913(+) GTCCCA/GTCTCC 1 -- ut310--------
    rs1388894531,2
    C--34644940(+) CTCCAA/TCCTGG 1 -- ut310--------
    rs617606051,2
    C--34644965(-) TGTGGG/ATCAGT 1 -- ut312Minor allele frequency- A:0.01NS 92

    HapMap Linkage Disequilibrium report for MAPK11 (50702142 - 50709196 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for MAPK11 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724762CNV Deletion23290073
    nsv471223CNV Loss18288195
    nsv915495CNV Loss21882294
    dgv5060n71CNV Loss21882294
    nsv914517CNV Loss21882294
    dgv5055n71CNV Loss21882294
    dgv5059n71CNV Loss21882294
    nsv914525CNV Loss21882294
    nsv914524CNV Loss21882294
    dgv5058n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602898    OMIM disorders: --

    20/28 diseases for MAPK11 (see all 28):    About MalaCards
    trypanosomiasis    shigellosis    chagas disease    toxoplasmosis
    non-hodgkin lymphoma    hodgkin's lymphoma    lateral sclerosis    amyotrophic lateral sclerosis
    pertussis    leishmaniasis    duodenitis    nasopharyngitis
    pheochromocytoma    ischemia    influenza    endotheliitis
    b-cell lymphomas    hepatitis c    retinoblastoma    alcoholism


    MAPK11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for MAPK11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 35 2 9252422 (1), 10988297 (1)
    necrosis 18.6 1 9029150 (1)
    inflammation 8.21 4 20134354 (1), 17482683 (1), 10207622 (1), 14694199 (1)
    ischemia 0 1 12425942 (1)
    breast cancer 0 1 12475989 (1)

    Genetic Association Database (GAD): MAPK11
    Human Genome Epidemiology (HuGE) Navigator: MAPK11 (6 documents)

    Export disorders for MAPK11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK11 gene, integrated from 9 sources (see all 148):
    (articles sorted by number of sources associating them with MAPK11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PubMed id 9218798)1, 2, 3, 9 Goedert M.... Cohen P. (1997)
    2. p38-2, a novel mitogen-activated protein kinase with distinct properties. (PubMed id 9235954)1, 2, 9 Stein B....Barbosa M.S. (1997)
    3. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. (PubMed id 9207191)1, 2, 9 Kumar S.... Young P.R. (1997)
    4. Characterization of the structure and function of a new mitogen- activated protein kinase (p38beta). (PubMed id 8663524)1, 2, 9 Jiang Y.... Han J. (1996)
    5. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. (PubMed id 10330143)1, 2, 9 Yang S.-H.... Sharrocks A.D. (1999)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    8. Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression. (PubMed id 15356147)1, 2 Mahlknecht U....Herbein G. (2004)
    9. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5600 HGNC: 6873 AceView: MAPK11 Ensembl:ENSG00000185386 euGenes: HUgn5600
    ECgene: MAPK11 Kegg: 5600 H-InvDB: MAPK11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK11 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mapk11/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAPK11 gene:
    Search GeneIP for patents involving MAPK11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK11
     SwitchGear 3'UTR luciferase reporter plasmids for MAPK11
     SwitchGear Promoter luciferase reporter plasmids for MAPK11
     ThermoFisher Antibodies for MAPK11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK11
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MAPK11
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAPK11
    Customized:
     lentivirus for stable overexpression of MAPK11
     lentivirus expression plasmids for stable overexpression of MAPK11
     adenovirus for overexpression of MAPK11
     LSBio Antibodies in human, mouse, rat for MAPK11
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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