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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAPK11 Gene

protein-coding   GIFtS: 71
GCID: GC22M050702

mitogen-activated protein kinase 11


(Previous symbol: PRKM11)
 Explore 31 diseases affiliated with
MAPK11 via
MalaCards
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 Human Malady Compendium 
Biological research products
for MAPK11    

Aliases
for MAPK11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase 111 2     EC 2.7.11.243 8
PRKM111 2 3     P38B2
SAPK21 2 3     P38BETA22
P38-21     Mitogen-Activated Protein Kinase P38-22
P38Beta1     Stress-Activated Protein Kinase 22
Mitogen-Activated Protein Kinase P38 Beta2 3     Stress-Activated Protein Kinase-22
Stress-Activated Protein Kinase 2b2 3     Stress-Activated Protein Kinase-2b2
SAPK2B2 3     SAPK2b3
MAP Kinase 112 3     P38b1
MAP Kinase P38 Beta2 3     EC 2.7.118
MAPK 112 3     

External Ids:    HGNC: 68731   Entrez Gene: 56002   Ensembl: ENSG000001853867   OMIM: 6028985   UniProtKB: Q157593   

Export aliases for MAPK11 gene to outside databases

Previous GC identifers: GC22M047253 GC22M048884 GC22M048874 GC22M049004 GC22M049044 GC22M033599


Summaries
for MAPK11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPK11:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,
both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through
its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown
to be a substrate of this kinase. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by
extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of
transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that
they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14.
Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate
additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such
as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the
nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of
immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by
recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3,
participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36
(tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during
translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by
phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of
protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is
regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as
well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17.
Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in
the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1.
FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates
processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus,
many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical
examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as
important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several
genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of
histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the
accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment

summary for MAPK11:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK11


Genomic Views
for MAPK11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_018933.1  NC_000022.10  NT_011526.7  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPK11 gene promoter:
         CRE-BP1   p53   ATF-2   NRSF form 1   STAT3   NF-kappaB1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAPK11 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAPK11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

MAPK11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK11 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050702:  view genomic region     (about GC identifiers)

Start:
 50,702,142 bp from pter      End:
 50,709,196 bp from pter
Size:
 7,055 bases      Orientation:
 minus strand

Proteins
for MAPK11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 11  
Size: 364 amino acids; 41357 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with HDAC3 and DUSP16
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
3 PDB 3D structures from and Proteopedia for MAPK11:
3GC8 (3D)        3GC9 (3D)        3GP0 (3D)    
Secondary accessions: B0LPG1 O00284 O15472 Q2XNF2

Explore the universe of human proteins at neXtProt for MAPK11: NX_Q15759

Post-translational modifications:

  • Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6, which activates the enzyme1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15759

    • 4/18 DME Specific Peptides for MAPK11 (Q15759) (see all 18)
     ILDFGLA  LDFGLAR  LKYIHSA  LLDVFTP 

    MAPK11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002742.3  
    ENSEMBL proteins: 
     ENSP00000333685   ENSP00000379113   ENSP00000409136   ENSP00000406921  
    Reactome Protein details: Q15759
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAPK11 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MAPK11
    OriGene Protein Over-expression Lysate: MAPK11
    OriGene Custom Protein Services for MAPK11 
    GenScript Custom Purified and Recombinant Proteins Services for MAPK11
    Novus Biologicals MAPK11 Proteins
    Novus Biologicals MAPK11 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MAPK11
    Uscn Proteins for MAPK11

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--


    MAPK11 for ontologies           About GeneDecksing



    MAPK11 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK11
    R&D Systems Antibodies for MAPK11 (p38 beta)
    Cell Signaling Technology (CST) Antibodies for MAPK11  (p38-beta)
    OriGene Antibodies: MAPK11
    OriGene Custom Antibody Services for MAPK11 
    GenScript Custom Superior Antibodies Services for MAPK11
    Novus Biologicals MAPK11 Antibodies
    Abcam antibodies for MAPK11 
    Uscn Antibodies for MAPK11
    ThermoFisher Antibodies for MAPK11

    Assay Products for MAPK11: 
    EMD Millipore Kits and Assays for the Analysis of MAPK11
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for MAPK11 (p38 beta)         (see all)
    GenScript Custom Assay Services for MAPK11
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK11 (p38-beta)
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAPK11

    Protein Domains /
    Families
    for MAPK11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPK11 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR003527 MAP_kinase_CS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q15759

    ProtoNet protein and cluster: Q15759

    2 Blocks protein families:
    IPB003527 MAP kinase
    IPB008352 P38 MAP kinase signature


    UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAPK11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
    MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by
    extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of
    transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that
    they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14.
    Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate
    additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such
    as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the
    nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of
    immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by
    recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3,
    participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36
    (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during
    translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by
    phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of
    protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is
    regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as
    well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17.
    Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in
    the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1.
    FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates
    processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus,
    many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical
    examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as
    important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several
    genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of
    histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the
    accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on threonine and tyrosine by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6.
    MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 induced by environmental stress. HDAC3
    interacts directly and selectively with MAPK11 to repress ATF2 transcriptional activity, and regulate TNF gene
    expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related compounds

         Genatlas biochemistry entry for MAPK11:
    mitogen-activated protein kinase 11

    Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target MAPK11:
    hsa-mir-122 (MIRT003097)

    OriGene 3'-UTR Clone: MAPK11
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAPK11
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK11 (see all 11):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-873 hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK11 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK11 (see all 7)
    OriGene shRNA RFP: MAPK11
    OriGene siRNA: MAPK11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAPK11

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAPK11

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK11 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAPK11 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAPK11 (NM_002751)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK11 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAPK11
    Search LifeMap BioReagents cell lines for MAPK11

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK11

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004707MAP kinase activity IDA10330143
    GO:0005515protein binding IPI17254968
    GO:0005524ATP binding IEA--


    MAPK11 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MAPK11:
     Decreased viability with RAF26  Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-outs for MAPK11: Mapk11tm1Okee Mapk11tm1Jsca
         14 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Mapk11):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  normal  reproductive system  skeleton 

    MAPK11 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPK11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/120 super-pathways (see all 120) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2ErbB4 Pathway
    8/10 pathways (see all 10)
    		ErbB4 Pathway1.00
    		LPS Stimulated MAPK Signaling0.36
    		ErbB Family Pathway0.59
    		VEGF Signaling Pathway0.35
    		Prolactin Signaling0.54
    		TREM1 Pathway0.32
    		IL-2 Pathway0.46
    		HMGB1 Pathway0.32
    3G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    		G-protein signaling Ras family GTPases in kinase cascades (scheme)1.00
    		Activation of the AP-1 family of transcription factors0.33
    		G-protein signaling_Ras family GTPases in kinase cascades (scheme)1.00
    		Immune response_Role of integrins in NK cells cytotoxicity0.28
    		Immune response_Oncostatin M signaling via MAPK in human cells0.39
    		Immune response Role of integrins in NK cells cytotoxicity0.28
    		Immune response Oncostatin M signaling via MAPK in human cells0.39
    		Rapid glucocorticoid signaling0.12
    44-1BB Pathway
    		4-1BB Pathway1.00
    		PKR Pathway0.36
    		CD40 Signaling0.54
    		NF-KappaB Activation by EBV0.31
    		CMV and MAPK Pathways0.38
    		SUMO Pathway0.30
    5Toll Comparative Pathway
    		Toll Comparative Pathway1.00
    		Immune response MIF in innate immunity response0.46
    		TLR-TRIF Pathway0.61
    		IL-1 Pathway0.39
    		Immune response_MIF in innate immunity response0.46
    		iNOS Signaling0.34

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/25 EMD Millipore Pathways for MAPK11 (see all 25)
        Development A1 receptor signaling
    Immune response MIF in innate immunity response
    G-protein signaling G-Protein alpha-12 signaling pathway
    Development TGF-beta receptor signaling
    Immune response CCR3 signaling in eosinophils

    3 R&D Systems Pathways for MAPK11
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways
    TGF-beta Signaling Pathways

    5/90 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAPK11 (see all 90)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK11
        MAP Kinase Signaling

    4 Tocris Bioscience Pathways for MAPK11
        Toll-like Receptor Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    MAPK Pathway

    5/27 GeneGo (Thomson Reuters) Pathways for MAPK11 (see all 27)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development FGF-family signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway

    5/20 BioSystems Pathways for MAPK11 (see all 20) 
        Parkinsons Disease Pathway
    Insulin Signaling
    Toll-like receptor signaling pathway
    IL-4 signaling Pathway
    ATF-2 transcription factor network

    5/48        Reactome Pathways for MAPK11 (see all 48)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    p38MAPK events
    Activation of p38 alpha/beta MAPK
    Toll Like Receptor 3 (TLR3) Cascade

    1 PharmGKB Pathway for MAPK11
        VEGF Signaling Pathway

    5/22         Kegg Pathways  (Kegg details for MAPK11) (see all 22):
        MAPK signaling pathway
    VEGF signaling pathway
    Osteoclast differentiation
    Toll-like receptor signaling pathway
    NOD-like receptor signaling pathway


    MAPK11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPK11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/179 Interacting proteins for MAPK11 (Q157591, 2, 3 ENSP000003336854) via UniProtKB, MINT, STRING, and/or I2D (see all 179)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C9orf78Q9NZ632, 3, ENSP000003615244MINT-8260504 I2D: score=2 STRING: ENSP00000361524
    POLR3DP054232, 3, ENSP000003030884MINT-8260537 I2D: score=2 STRING: ENSP00000303088
    TP53P046371, 3, ENSP000002693054EBI-303766,EBI-366083 I2D: score=2 STRING: ENSP00000269305
    CPNE6O957412, 3MINT-8260515 I2D: score=2 
    ATF2P153362, 3, ENSP000002641104MINT-4789511 I2D: score=5 STRING: ENSP00000264110
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--


    MAPK11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPK11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAPK11 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAPK11:
    Small Molecule - inhibitor
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    Compounds for MAPK11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RWJ 67657 Potent, selective p38alpha and p38beta inhibitor [215303-72-3]
    SB 239063 Potent, selective p38 MAPK inhibitor; orally active [193551-21-2]
    EO 1428Selective inhibitor of p38alpha and p38beta2[321351-00-2]
    SB 203580Selective inhibitor of p38 MAPK[152121-47-6]
    SKF 86002 dihydrochloridep38 MAPK inhibitor; anti-inflammatory agent[72873-74-6]

    3 HMDB Compounds for MAPK11    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    9 Novoseek chemical compound relationships for MAPK11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 83.9 10 10585868 (1), 16151644 (1), 17481747 (1), 20053787 (1) (see all 8)
    wortmannin 46.4 4 10585868 (1), 9252422 (1), 9873045 (1)
    arsenite 37.9 3 9252422 (1), 9873045 (1), 12475989 (1)
    phosphatidylinositol 23.8 1 9873045 (1)
    ly294002 23.4 2 10585868 (1)
    oxygen 0 2 14997018 (1), 18323531 (1)
    glucose 0 13 9873045 (4), 9252422 (3), 10585868 (2), 15947002 (2) (see all 5)
    calcium 0 1 9412491 (1)
    serine 0 2 9199504 (1)

    Search CenterWatch for drugs/clinical trials and news about MAPK11 / MK11 

    Transcripts
    for MAPK11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAPK11 gene (2 alternative transcripts): 
    NM_002751.5  NM_138993.2  

    Unigene Cluster for MAPK11:

    Mitogen-activated protein kinase 11
    Hs.57732  [show with all ESTs]
    Unigene Representative Sequence: BC027933
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330651(uc003bkr.3) ENST00000395764(uc010hay.1) ENST00000417877
    ENST00000495277 ENST00000449719(uc011art.1 uc010haz.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MAPK11
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MAPK11 (see all 11):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-873 hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmid: MAPK11 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAPK11 (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AF001008.1 AF001174.1 AF031135.1 AK291845.1 AK299745.1 AK308969.1 AK309046.1 BC027933.1 
    CR456514.1 Y14440.1 

    7 DOTS entries:

    DT.441095  DT.100021341  DT.100767888  DT.100649627  DT.312511  DT.95131967  DT.100721291 

    24/61 AceView cDNA sequences (see all 61):

    AL157630 CR592517 BC027933 NM_002751 NM_138993 CR605909 CR615085 CR600695 
    CR624704 BM857051 BX444192 BQ894152 D60172 BX368846 BX326651 BX359036 
    BX407240 BX367446 BM553124 BM543964 BM801437 BX325523 BX411138 AF031135 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAPK11 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14
    SP1:                    -                                                     -     -                       -     -         
    SP2:                    -                                                     -     -                                       
    SP3:                    -                                                                                                   
    SP4:                                                                                                                        
    SP5:        -           -     -                                                                                             


    ECgene alternative splicing isoforms for MAPK11

    Expression
    for MAPK11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAPK11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCAGGGGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAPK11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAPK11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAPK11

    SOURCE GeneReport for Unigene cluster: Hs.57732

    UniProtKB/Swiss-Prot: MK11_HUMAN, Q15759
    Tissue specificity: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal
    muscle, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAPK11: 
              Inflammasomes in human mouse rat
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    Orthologs
    for MAPK11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK11 gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAPK111 mitogen-activated protein kinase 11 71.51(n)
    84.64(a)    		   417739  NM_001006227.1  NP_001006227.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAPK116
    		 --
    		 84(a)
    		 1 ↔ 1
    		 5(64268774-64319908)
    zebrafish
    (Danio rerio)    		 Actinopterygii mapk111 mitogen-activated protein kinase 11 71.88(n)
    83.52(a)    		   415185  NM_001002095.1  NP_001002095.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta p38b3 regulation of BMP signaling pathway protein
    serine/threonine more    		 67(a)
    (best of 3)    		   34D1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea pmk-13 ser/thr kinases 64(a)
    (best of 6)    		   IV(8148976-8149980)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MPK121 mitogen-activated protein kinase 12 52.43(n)
    48.61(a)    		   819215  NM_130170.3  NP_182131.2 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 16)    		 CGMC_MAPKCMGC_2_SLT2y_ERK.1 - CGMC includes CDA, M...
    CGMC_MAPKCMGC_2_SLT2y_ERK.2 - CGMC includes CDA, M...
    (see all 16)    		 43(a)
    43(a)
    (see all 16)    		 many ↔ many
    many ↔ many
    (see all 16)    		 2(2642975-2646358)
    6(29397209-29401633)


    ENSEMBL Gene Tree for MAPK11 (if available)
    TreeFam Gene Tree for MAPK11 (if available) 

    Paralogs
    for MAPK11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAPK11 gene
    MAPK92  MAPK122  MAPK132  MAPK142  MAPK102  MAPK82  
    18/51 SIMAP similar genes for MAPK11 using alignment to 4 protein entries:     MK11_HUMAN (see all proteins) (see all similar genes):
    MAPK14    MAPK12    DKFZp686M02159    MAPK13    MAPK10    MAPK8
    MAPK9    MAPK7    DKFZp686O0215    MAPK3    NLK    MAPK1
    MAPK4    CDK20    MAPK15    MAPK6    CDKL4    CDKL2

    MAPK11 for paralogs           About GeneDecksing



    Genomic Variants
    for MAPK11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/304 NCBI SNPs in MAPK11 are shown (see all 304)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs349856801,2
    		C,F,--33599234(-) CCACCC/TCCGCC 1 -- us2k17Minor allele frequency- T:0.01NS 280
    rs617606071,2
    		C,F,--33599492(-) CGTGGG/AGGGAG 1 -- us2k15Minor allele frequency- A:0.06NS CSA WA 215
    rs617606061,2
    		C,--33599496(-) TGGGCG/TTGGGG 1 -- us2k12Minor allele frequency- T:0.01NS 94
    rs1867544101,2
    		C,--33599525(+) GCACCC/TGGGCC 1 -- us2k10--------
    rs1461980011,2
    		C,--33599694(+) GTCCCA/GTCTCC 1 -- us2k10--------
    rs1388894531,2
    		C,--33599721(+) CTCCAA/TCCTGG 1 -- us2k10--------
    rs617606041,2
    		C,F,--33599773(-) CAGCCG/AGAGAT 1 -- us2k14Minor allele frequency- A:0.02NS CSA WA 212
    rs2019171941,2
    		C--33599780(+) GCTGCA/GGGGCC 1 -- us2k10--------
    rs617606031,2
    		C--33599823(-) TGCCCT/CGCACC 1 -- us2k12Minor allele frequency- C:0.01NS 92
    rs341147261,2
    		C,F,H,--33599831(-) GACACT/CTCTGC 1 -- us2k18Minor allele frequency- C:0.01NS NA 690

    HapMap Linkage Disequilibrium report for MAPK11 (50702142 - 50709196 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MAPK11
         1 CNV: 30166

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    Disorders / Diseases
    for MAPK11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPK11 for disorders           About GeneDecksing

    OMIM gene information: 602898    OMIM disorders: --

    20/31 diseases for MAPK11 (see all 31):    About MalaCards
    b-cell non-hodgkin lymphoma    neurodegeneration    non-hodgkin lymphoma    amyotrophic lateral sclerosis (als)
    amyotrophic lateral sclerosis    lateral sclerosis    hodgkin's lymphoma    b-cell lymphomas
    chagas disease    shigellosis    hepatitis c    trypanosomiasis
    toxoplasmosis    leishmaniasis    breast cancer    ischemia
    duodenitis    pheochromocytoma    pertussis    hepatocellular carcinoma

    5 Novoseek disease relationships for MAPK11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 35 2 9252422 (1), 10988297 (1)
    necrosis 18.6 1 9029150 (1)
    inflammation 8.21 4 20134354 (1), 17482683 (1), 10207622 (1), 14694199 (1)
    ischemia 0 1 12425942 (1)
    breast cancer 0 1 12475989 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAPK11 (6 documents)

    Export disorders for MAPK11 gene to outside databases

    Publications
    for MAPK11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAPK11 gene, integrated from 9 sources (see all 143):
    (articles sorted by number of sources associating them with MAPK11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PubMed id 9218798)1, 2, 3, 9 Goedert M.... Cohen P. (1997)
    2. p38-2, a novel mitogen-activated protein kinase with distinct properties. (PubMed id 9235954)1, 2, 9 Stein B....Barbosa M.S. (1997)
    3. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. (PubMed id 9207191)1, 2, 9 Kumar S.... Young P.R. (1997)
    4. Characterization of the structure and function of a new mitogen- activated protein kinase (p38beta). (PubMed id 8663524)1, 2, 9 Jiang Y.... Han J. (1996)
    5. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. (PubMed id 10330143)1, 2, 9 Yang S.-H.... Sharrocks A.D. (1999)
    6. Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression. (PubMed id 15356147)1, 2 Mahlknecht U....Herbein G. (2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. (PubMed id 11359773)1, 2 Tanoue T....Nishida E. (2001)
    10. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)

    External Searches for MAPK11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAPK11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5600 HGNC: 6873 AceView: MAPK11 Ensembl:ENSG00000185386 euGenes: HUgn5600
    ECgene: MAPK11 Kegg: 5600 H-InvDB: MAPK11

    Other Databases showing MAPK11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAPK11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAPK11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK11 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mapk11/

    Intellectual Property
    for MAPK11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAPK11 gene:
    Search GeneIP for patents involving MAPK11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    for MAPK11 gene

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    About This Section

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     SwitchGear 3'UTR luciferase reporter plasmids for MAPK11
     SwitchGear Promoter luciferase reporter plasmids for MAPK11
     ThermoFisher Antibodies for MAPK11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK11
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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