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Aliases for MAPK11 Gene

Aliases for MAPK11 Gene

  • Mitogen-Activated Protein Kinase 11 2 3
  • Mitogen-Activated Protein Kinase P38 Beta 3 4
  • MAP Kinase P38 Beta 3 4
  • MAP Kinase 11 3 4
  • EC 2.7.11.24 4 64
  • PRKM11 3 4
  • SAPK2B 3 4
  • SAPK2 3 4
  • P38-2 3 4
  • P38B 3 4
  • Mitogen-Activated Protein Kinase P38-2 3
  • Stress-Activated Protein Kinase-2b 3
  • Stress-Activated Protein Kinase 2b 4
  • Stress-Activated Protein Kinase-2 3
  • EC 2.7.11 64
  • P38BETA2 3
  • P38Beta 3
  • MAPK 11 4

External Ids for MAPK11 Gene

Previous Symbols for MAPK11 Gene

  • PRKM11

Summaries for MAPK11 Gene

Entrez Gene Summary for MAPK11 Gene

  • This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for MAPK11 Gene

MAPK11 (Mitogen-Activated Protein Kinase 11) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase activity. An important paralog of this gene is MAPK12.

UniProtKB/Swiss-Prot for MAPK11 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment.

Tocris Summary for MAPK11 Gene

  • MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases (ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7), ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and 2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38 MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and inflammation (p38).

Gene Wiki entry for MAPK11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK11 Gene

Genomics for MAPK11 Gene

Genomic Location for MAPK11 Gene

Start:
50,263,713 bp from pter
End:
50,270,767 bp from pter
Size:
7,055 bases
Orientation:
Minus strand

Genomic View for MAPK11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK11 Gene

Regulatory Elements for MAPK11 Gene

Proteins for MAPK11 Gene

  • Protein details for MAPK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15759-MK11_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 11
    Protein Accession:
    Q15759
    Secondary Accessions:
    • A8K730
    • B0LPG1
    • B7Z630
    • E7ETQ1
    • L7RT27
    • O00284
    • O15472
    • Q2XNF2

    Protein attributes for MAPK11 Gene

    Size:
    364 amino acids
    Molecular mass:
    41357 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with HDAC3 and DUSP16.

    Three dimensional structures from OCA and Proteopedia for MAPK11 Gene

    Alternative splice isoforms for MAPK11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK11 Gene

Proteomics data for MAPK11 Gene at MOPED

Post-translational modifications for MAPK11 Gene

  • Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6, which activates the enzyme.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MAPK11 Gene

Gene Families for MAPK11 Gene

UniProtKB/Swiss-Prot:

MK11_HUMAN
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases:
    • Q15759
  • Contains 1 protein kinase domain.:
    • Q15759
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.:
    • Q15759
genes like me logo Genes that share domains with MAPK11: view

Function for MAPK11 Gene

Molecular function for MAPK11 Gene

GENATLAS Biochemistry: mitogen-activated protein kinase 11
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on threonine and tyrosine by MAP2K3/MKK3, MAP2K4/MKK4 and MAP2K6/MKK6. MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 induced by environmental stress. HDAC3 interacts directly and selectively with MAPK11 to repress ATF2 transcriptional activity, and regulate TNF gene expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related compounds.
UniProtKB/Swiss-Prot Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on Ser-10 (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment.

Enzyme Numbers (IUBMB) for MAPK11 Gene

Gene Ontology (GO) - Molecular Function for MAPK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004707 MAP kinase activity IDA 10330143
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 17254968
genes like me logo Genes that share ontologies with MAPK11: view
genes like me logo Genes that share phenotypes with MAPK11: view

Animal Models for MAPK11 Gene

MGI Knock Outs for MAPK11:

miRNA for MAPK11 Gene

miRTarBase miRNAs that target MAPK11

No data available for Transcription Factor Targeting and HOMER Transcription for MAPK11 Gene

Localization for MAPK11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK11 Gene COMPARTMENTS Subcellular localization image for MAPK11 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAPK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MAPK11: view

Pathways for MAPK11 Gene

genes like me logo Genes that share pathways with MAPK11: view

Gene Ontology (GO) - Biological Process for MAPK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with MAPK11: view

Compounds for MAPK11 Gene

(10) ApexBio Compounds for MAPK11 Gene

Compound Action Cas Number
BIRB 796 (Doramapimod) Cell pemeable p38 MAP Kinase Inhibitor [285983-48-4]
LY2228820 Potent and ATP-competitive p38 MAP kinase inhibitor [862507-23-1]
PD 169316 p38 MAPK inhibitor [152121-53-4]
PH-797804 Potent and selective p38 MAP kinase inhibitor [586379-66-0]
SB 203580 Cell permeable, reversible, and ATP-competitive p38 MAP kinase inhibitor [152121-47-6]
SB202190 (FHPI) highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. [152121-30-7]
Skepinone-L selective p38 mitogen-activated protein kinase inhibitor. [1221485-83-1]
TAK-715 inhibitor of p38 MAPK [303162-79-0]
VX-702 P38 MAPK inhibitor [479543-46-9]
VX-745 highly potent and selective p38alpha inhibitor [209410-46-8]

(5) Tocris Compounds for MAPK11 Gene

Compound Action Cas Number
SB 202190 Potent, selective inhibitor of p38 MAPK [152121-30-7]
SB 203580 Selective inhibitor of p38 MAPK [152121-47-6]
SB 203580 hydrochloride Selective inhibitor of p38 MAPK; water-soluble [152121-47-6]
SB 239063 Potent, selective p38 MAPK inhibitor; orally active [193551-21-2]
SCIO 469 hydrochloride Selective p38 MAPK inhibitor [309913-83-5]

(3) HMDB Compounds for MAPK11 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(1) Drugbank Compounds for MAPK11 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Regorafenib
755037-03-7 target inhibitor

(9) Novoseek inferred chemical compound relationships for MAPK11 Gene

Compound -log(P) Hits PubMed IDs
sb 203580 83.9 8
wortmannin 46.4 3
arsenite 37.9 3
phosphatidylinositol 23.8 1
ly294002 23.4 1
genes like me logo Genes that share compounds with MAPK11: view

Transcripts for MAPK11 Gene

Unigene Clusters for MAPK11 Gene

Mitogen-activated protein kinase 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14
SP1: - - - - -
SP2: - - -
SP3: -
SP4:
SP5: - - -
SP6:

Relevant External Links for MAPK11 Gene

GeneLoc Exon Structure for
MAPK11
ECgene alternative splicing isoforms for
MAPK11

Expression for MAPK11 Gene

mRNA expression in normal human tissues for MAPK11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAPK11 Gene

SOURCE GeneReport for Unigene cluster for MAPK11 Gene Hs.57732

mRNA Expression by UniProt/SwissProt for MAPK11 Gene

Q15759-MK11_HUMAN
Tissue specificity: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expressions with MAPK11: view

Orthologs for MAPK11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPK11 36
  • 90.98 (n)
  • 96.3 (a)
MAPK11 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK11 36
  • 90.27 (n)
  • 95.14 (a)
mouse
(Mus musculus)
Mammalia Mapk11 36
  • 88.83 (n)
  • 97.25 (a)
Mapk11 16
Mapk11 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPK11 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK11 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk11 36
  • 88.64 (n)
  • 96.7 (a)
chicken
(Gallus gallus)
Aves MAPK11 36
  • 71.04 (n)
  • 84.08 (a)
MAPK11 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK11 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk11 36
  • 69.53 (n)
  • 82.27 (a)
zebrafish
(Danio rerio)
Actinopterygii mapk11 36
  • 71.04 (n)
  • 82.96 (a)
mapk11 37
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mpk2 37
  • 63 (a)
ManyToMany
p38b 37
  • 65 (a)
ManyToMany
p38c 37
  • 41 (a)
ManyToMany
Mpk2 38
  • 65 (a)
p38b 38
  • 67 (a)
p38c 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea pmk-1 37
  • 59 (a)
ManyToMany
pmk-2 37
  • 48 (a)
ManyToMany
Y51B9A.9 38
  • 33 (a)
pmk-3 38
  • 41 (a)
C49C3.10a 38
  • 28 (a)
F09C12.2 38
  • 38 (a)
pmk-1 38
  • 64 (a)
C49C3.10b 38
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOG1 37
  • 39 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MPK10 36
  • 52.02 (n)
  • 46.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 65 (a)
OneToMany
Species with no ortholog for MAPK11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK11 Gene

ENSEMBL:
Gene Tree for MAPK11 (if available)
TreeFam:
Gene Tree for MAPK11 (if available)

Paralogs for MAPK11 Gene

Paralogs for MAPK11 Gene

genes like me logo Genes that share paralogs with MAPK11: view

Variants for MAPK11 Gene

Sequence variations from dbSNP and Humsavar for MAPK11 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs742185 -- 50,266,630(+) AGGGG(A/G)CCTCC intron-variant
rs742186 -- 50,268,262(-) GCACC(C/T)CTCCC intron-variant
rs760747 -- 50,266,875(+) CAGAG(C/T)CAGTC intron-variant
rs909691 -- 50,271,066(+) CCCTG(A/G)CTATC upstream-variant-2KB
rs909692 -- 50,272,204(+) GGCGT(C/G)AGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAPK11 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
dgv5051n71 CNV Loss 21882294
dgv5054n71 CNV Loss 21882294
dgv781n67 CNV Gain 20364138
dgv5055n71 CNV Loss 21882294
nsv914515 CNV Gain 21882294
nsv471223 CNV Loss 18288195
nsv914517 CNV Loss 21882294
dgv5058n71 CNV Loss 21882294
nsv914523 CNV Loss 21882294
nsv914524 CNV Loss 21882294
nsv914525 CNV Loss 21882294
dgv5059n71 CNV Loss 21882294
dgv5060n71 CNV Loss 21882294
esv2724762 CNV Deletion 23290073
dgv782n67 CNV Gain 20364138

Relevant External Links for MAPK11 Gene

HapMap Linkage Disequilibrium report
MAPK11

Disorders for MAPK11 Gene

(5) Novoseek inferred disease relationships for MAPK11 Gene

Disease -log(P) Hits PubMed IDs
shock 35 2
necrosis 18.6 1
inflammation 8.21 4
ischemia 0 1
breast cancer 0 1

Relevant External Links for MAPK11

Genetic Association Database (GAD)
MAPK11
Human Genome Epidemiology (HuGE) Navigator
MAPK11
genes like me logo Genes that share disorders with MAPK11: view

No data available for UniProtKB/Swiss-Prot for MAPK11 Gene

Publications for MAPK11 Gene

  1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PMID: 9218798) Goedert M. … Cohen P. (EMBO J. 1997) 2 3 4 23
  2. p38-2, a novel mitogen-activated protein kinase with distinct properties. (PMID: 9235954) Stein B. … Barbosa M.S. (J. Biol. Chem. 1997) 3 4 23
  3. Characterization of the structure and function of a new mitogen- activated protein kinase (p38beta). (PMID: 8663524) Jiang Y. … Han J. (J. Biol. Chem. 1996) 3 4 23
  4. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. (PMID: 10330143) Yang S.-H. … Sharrocks A.D. (Mol. Cell. Biol. 1999) 3 4 23
  5. The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha. (PMID: 19622861) Patel S.B. … Scapin G. (Acta Crystallogr. D 2009) 3 4 23

Products for MAPK11 Gene

Sources for MAPK11 Gene

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