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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAPK10 Gene

protein-coding GIFtS: 71
GCID: GC04M086878

mitogen-activated protein kinase 10

(Previous symbol: PRKM10)

Explore 142 diseases affiliated with
MAPK10 via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase 10¹ ²		C-Jun N-Terminal Kinase 3² ³
JNK3¹ ² ³ ⁵		MAP Kinase 10² ³
PRKM10¹ ² ³ ⁵		MAP Kinase P49 3F12² ³
P493F12¹		MAPK 10² ³
P54bSAPK¹		EC 2.7.11.24³ ⁸
Stress-Activated Protein Kinase 1b² ³		JNK3 Alpha Protein Kinase²
Stress-Activated Protein Kinase JNK3² ³		Stress Activated Protein Kinase Beta²
JNK3A² ³		SAPK1B³
SAPK1b² ³		EC 2.7.11⁸

External Ids:	HGNC: 6872¹	Entrez Gene: 5602²	Ensembl: ENSG00000109339⁷	OMIM: 602897⁵	UniProtKB: P53779³

Export aliases for MAPK10 gene to outside databases

Previous GC identifers: GC04M087239 GC04M087396 GC04M087294 GC04M087156 GC04M082680

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPK10:

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for

multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,

differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun

N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in

the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein,

is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4).

Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in

preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been

reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MK10_HUMAN, P53779

Function: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation,

differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or

physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In

this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In

turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2

and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal

apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid

precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite

growth in spiral ganglion neurons

summary for MAPK10:

MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of

cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases

(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),

ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and

are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and

2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream

kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38

MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and

hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase

pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and

inflammation (p38).

Gene Wiki entry for MAPK10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAPK10 gene promoter:
CREB deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAPK10 promoter sequence

Search SABiosciences Chromatin IP Primers for MAPK10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAPK10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1-q23 Ensembl cytogenetic band: 4q21.3 HGNC cytogenetic band: 4q22-q23

MAPK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK10 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M086878: view genomic region (about GC identifiers)

Start:	86,936,276 bp from pter	End:	87,515,284 bp from pter
Size:	579,009 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MK10_HUMAN, P53779 (See protein sequence)

Recommended Name: Mitogen-activated protein kinase 10

Size: 464 amino acids; 52585 Da

Cofactor: Magnesium

Subunit: Interacts with MAPKBP1 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1,

MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK

signaling pathway. Interacts with HDAC9. Interacts with ARRB2; the interaction enhances MAPK10 activation by MAP3K5.

Interacts with SARM1 (By similarity)

Subcellular location: Cytoplasm. Membrane; Lipid-anchor. Nucleus. Mitochondrion. Note=Palmitoylation regulates MAPK10

trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity)

Mass spectrometry: Mass=44070; Method=Electrospray; Range=1-464; Source=PubMed:10715136;

6/35 PDB 3D structures from and Proteopedia for MAPK10 (see all 35):

1JNK (3D)

1PMN (3D)

1PMQ (3D)

1PMU (3D)

1PMV (3D)

2B1P (3D)

Secondary accessions: A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1

Alternative splicing: 4 isoforms: P53779-1 P53779-2 P53779-3 P53779-4

Explore the universe of human proteins at neXtProt for MAPK10: NX_P53779

Post-translational modifications:

Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong

preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and

tyrosine residues in vitro¹

Palmitoylation regulates subcellular location and axonal development¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P53779

4/29 DME Specific Peptides for MAPK10 (P53779) (see all 29)

KELIYKE

ILDFGLA

LDFGLAR

LLSKMLV

MAPK10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_002744.1 NP_620446.1 NP_620447.1 NP_620448.1

ENSEMBL proteins:

ENSP00000378598 ENSP00000309857 ENSP00000352157 ENSP00000378586 ENSP00000355297

ENSP00000378595 ENSP00000378589 ENSP00000424154 ENSP00000424755 ENSP00000422985

ENSP00000422277 ENSP00000421762 ENSP00000424128 ENSP00000421359 ENSP00000425654

ENSP00000423918 ENSP00000421409 ENSP00000420987 ENSP00000414469 ENSP00000378590

Reactome Protein details: P53779
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant MAPK10 Protein
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for MAPK10
	OriGene Purified Proteins (see all 2): MAPK10 OriGene Protein Over-expression Lysate (see all 3): MAPK10 OriGene Custom Protein Services for MAPK10
	GenScript Custom Purified and Recombinant Proteins Services for MAPK10
	Novus Biologicals MAPK10 Proteins Novus Biologicals MAPK10 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAPK10

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	ISS	--
GO:0005739	mitochondrion	ISS	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	ISS	--

MAPK10 for ontologies About GeneDecksing

MAPK10 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK10
	R&D Systems Antibodies for MAPK10 (JNK3)
	Cell Signaling Technology (CST) Antibodies for MAPK10 (JNK3)
	OriGene Antibodies (see all 3): MAPK10 OriGene Custom Antibody Services for MAPK10
	GenScript Custom Superior Antibodies Services for MAPK10
	Novus Biologicals MAPK10 Antibodies
	Abcam antibodies for MAPK10
	Uscn Antibodies for MAPK10
	ThermoFisher Antibodies for MAPK10

Assay Products for MAPK10:

	EMD Millipore Kits and Assays for the Analysis of MAPK10
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for MAPK10 (JNK3) (see all)
	GenScript Custom Assay Services for MAPK10
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MAPK10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAPK10 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR008351 MAPK_JNK

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR003527 MAP_kinase_CS

Graphical View of Domain Structure for InterPro Entry P53779

ProtoNet protein and cluster: P53779

2 Blocks protein families:

IPB003527 MAP kinase

IPB008351 JNK MAP kinase signature

UniProtKB/Swiss-Prot: MK10_HUMAN, P53779

Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: