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MAPK10 Gene

protein-coding   GIFtS: 73
GCID: GC04M086936

Mitogen-Activated Protein Kinase 10


(Previous symbol: PRKM10)
  See MAPK10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 101 2     MAP Kinase P49 3F122 3
PRKM101 2 3 5     MAPK 102 3
JNK32 3 5     EC 2.7.11.243 8
Stress-Activated Protein Kinase 1b2 3     JNK3 Alpha Protein Kinase2
Stress-Activated Protein Kinase JNK32 3     p493F122
JNK3A2 3     p54bSAPK2
SAPK1b2 3     Stress Activated Protein Kinase Beta2
C-Jun N-Terminal Kinase 32 3     SAPK1B3
MAP Kinase 102 3     EC 2.7.118

External Ids:    HGNC: 68721   Entrez Gene: 56022   Ensembl: ENSG000001093397   OMIM: 6028975   UniProtKB: P537793   

Export aliases for MAPK10 gene to outside databases

Previous GC identifers: GC04M086878 GC04M087239 GC04M087396 GC04M087294 GC04M087156 GC04M082680


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK10 Gene:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for
multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,
differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun
N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory
roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase
scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase
kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may
be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct
isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAPK10 Gene:
MAPK10 (mitogen-activated protein kinase 10) is a protein-coding gene. Diseases associated with MAPK10 include lennox-gastaut syndrome, and opioid abuse. GO annotations related to this gene include JUN kinase activity and MAP kinase kinase activity. An important paralog of this gene is MAPK9.

UniProtKB/Swiss-Prot: MK10_HUMAN, P53779
Function: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation,
differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or
physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling
pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate
MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1
such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling
pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the
regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating
APP. Participates also in neurite growth in spiral ganglion neurons

summary for MAPK10 Gene:
MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of
cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases
(ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7),
ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and
are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and
2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream
kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38
MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and
hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase
pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and
inflammation (p38).

Gene Wiki entry for MAPK10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK10 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAPK10 promoter sequence
   Search Chromatin IP Primers for MAPK10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1-q23   Ensembl cytogenetic band:  4q21.3   HGNC cytogenetic band: 4q22-q23

MAPK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M086936:  view genomic region     (about GC identifiers)

Start:
86,936,276 bp from pter      End:
87,515,284 bp from pter
Size:
579,009 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MK10_HUMAN, P53779 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 10  
Size: 464 amino acids; 52585 Da
Cofactor: Magnesium
Subunit: Interacts with MAPKBP1 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1,
MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the
JNK signaling pathway. Interacts with HDAC9. Interacts with ARRB2; the interaction enhances MAPK10 activation by
MAP3K5. Interacts with SARM1 (By similarity)
Mass spectrometry: Mass=44070; Method=Electrospray; Range=1-464; Source=PubMed:10715136;
Selected PDB 3D structures from and Proteopedia for MAPK10 (see all 36):
1JNK (3D)        1PMN (3D)        1PMQ (3D)        1PMU (3D)        1PMV (3D)        2B1P (3D)    
Secondary accessions: A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1
Alternative splicing: 4 isoforms:  P53779-1   P53779-2   P53779-3   P53779-4   

Explore the universe of human proteins at neXtProt for MAPK10: NX_P53779

Explore proteomics data for MAPK10 at MOPED

Post-translational modifications: 

  • Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a
    strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on
    threonine and tyrosine residues in vitro1
  • Palmitoylation regulates subcellular location and axonal development1
  • Ubiquitination2 at Lys204
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPK10 (P53779) (see all 29)
     KELIYKE  ILDFGLA  LDFGLAR  LLSKMLV 


    See MAPK10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_002744.1  NP_620446.1  NP_620447.1  NP_620448.1  

    ENSEMBL proteins: 
     ENSP00000378598   ENSP00000378586   ENSP00000352157   ENSP00000309857   ENSP00000355297  
     ENSP00000378589   ENSP00000378595   ENSP00000424154   ENSP00000424755   ENSP00000422985  
     ENSP00000422277   ENSP00000421762   ENSP00000424128   ENSP00000421359   ENSP00000425654  
     ENSP00000423918   ENSP00000421409   ENSP00000420987   ENSP00000414469   ENSP00000378590  
    Reactome Protein details: P53779

    MAPK10 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAPK10 Protein
    Browse R&D Systems for human recombinant proteins
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    OriGene Protein Over-expression Lysate for MAPK10
    OriGene MassSpec for MAPK10
    OriGene Custom Protein Services for MAPK10
    GenScript Custom Purified and Recombinant Proteins Services for MAPK10
    Novus Biologicals MAPK10 Proteins
    Novus Biologicals MAPK10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAPK10

     
    Search eBioscience for Proteins for MAPK10 

     
    antibodies-online proteins for MAPK10 (8 products) 

     
    antibodies-online peptides for MAPK10

    MAPK10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for MAPK10 (JNK3)
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    OriGene Antibodies for MAPK10
    OriGene Custom Antibody Services for MAPK10
    Novus Biologicals MAPK10 Antibodies
    Abcam antibodies for MAPK10
    Cloud-Clone Corp. Antibodies for MAPK10
    ThermoFisher Antibodies for MAPK10
    antibodies-online antibodies for MAPK10 (87 products) 

    MAPK10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAPK10
    R&D Systems ELISAs for MAPK10 (JNK3)         (see all)
    GenScript Custom Assay Services for MAPK10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAPK10
    Cloud-Clone Corp. CLIAs for MAPK10
    Search eBioscience for ELISAs for MAPK10 
    antibodies-online kits for MAPK10 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 10
    JNK subfamily
    Mitogen-activated protein kinases

    Selected InterPro protein domains (see all 6):
     IPR008351 MAPK_JNK
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR003527 MAP_kinase_CS

    Graphical View of Domain Structure for InterPro Entry P53779

    ProtoNet protein and cluster: P53779

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008351 JNK MAP kinase signature


    UniProtKB/Swiss-Prot: MK10_HUMAN, P53779
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAPK10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK10_HUMAN, P53779
    Function: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation,
    differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or
    physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling
    pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate
    MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1
    such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling
    pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the
    regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating
    APP. Participates also in neurite growth in spiral ganglion neurons
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and
    MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax.
    MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity
    phosphatases, such as DUSP1. Inhibited by HDAC9

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004705JUN kinase activity ISS8654373
    GO:0004707MAP kinase activity ----
    GO:0004708MAP kinase kinase activity TAS7826642
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with MAPK10           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for MAPK10:
     Increased cell death in breast  Increased viability with TRAIL  Synthetic lethal with gemcitab  Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mapk10):
     behavior/neurological  cardiovascular system  cellular  homeostasis/metabolism  nervous system 
     no phenotypic analysis 

    Find genes that share phenotypes with MAPK10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MAPK10: Mapk10tm1Lewc Mapk10tm1Flv

       genOway: Develop your customized and physiologically relevant rodent model for MAPK10

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MAPK10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK10 (see all 66):
    hsa-miR-193a-3p hsa-miR-128 hsa-miR-759 hsa-miR-629 hsa-miR-642b hsa-miR-130b hsa-miR-193b hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAPK10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPK10
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK10

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK10 (see all 28)
    OriGene ORF clones in mouse, rat for MAPK10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK10 (NM_002753)
    Sino Biological Human cDNA Clone for MAPK10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK10
    Addgene plasmids for MAPK10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK10
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MK10_HUMAN, P53779: Cytoplasm. Membrane; Lipid-anchor. Nucleus. Mitochondrion. Note=Palmitoylation regulates
    MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol4
    plasma membrane4
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ISS--
    GO:0005739mitochondrion ISS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ISS--

    Find genes that share ontologies with MAPK10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK10 About   (see all 125)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    2G protein signaling Ras family GTPases in kinase cascades scheme
    G protein signaling Ras family GTPases in kinase cascades scheme 0.44
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    MAPK Cascade0.44
    Activation of the AP-1 family of transcription factors0.00
    3TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    Apoptosis through Death Receptors0.42
    Apoptotic Pathways Triggered By HIV10.42
    Apoptosis Modulation by HSP700.35
    4Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Integrin-mediated cell adhesion0.38
    5Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Development EGFR signaling via PIP30.40
    Development Neurotrophin family signaling0.45
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Development EGFR signaling via small GTPases0.44
    Neurotrophin signaling pathway0.36
    Development PDGF signaling via MAPK cascades0.41
    Apoptosis and survival Anti apoptotic action of membrane bound ESR10.35


    Find genes that share SuperPaths with MAPK10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for MAPK10 (see all 7)
        NOD-like Receptor Signaling Pathways
    Wnt Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK10 (see all 107)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for MAPK10
        MAP Kinase Signaling

    Selected Tocris Bioscience Pathways for MAPK10 (see all 7)
        Akt Pathway
    Insulin Pathway
    Toll-like Receptor Pathway
    TGF-beta Pathway
    VEGF Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MAPK10 (see all 34)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

    Selected BioSystems Pathways for MAPK10 (see all 22)
        MAPK signaling pathway
    Apoptosis
    Integrin-mediated cell adhesion
    Wnt Signaling Pathway
    Insulin Signaling

    Selected Sino Biological Pathways for MAPK10 (see all 6)
        TNF Signaling
    EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    p53 Pathway
    Death Receptor Signaling

    4 Reactome Pathways for MAPK10
        Oxidative Stress Induced Senescence
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
    FCERI mediated MAPK activation
    Activation of the AP-1 family of transcription factors

    1 PharmGKB Pathway for MAPK10
        VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for MAPK10) (see all 39):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    FoxO signaling pathway
    Protein processing in endoplasmic reticulum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK10: 
              Antiviral Response in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK10 (P537791, 2, 3 ENSP000003521574) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054121, 2, 3, ENSP000003602664EBI-713543,EBI-852823 MINT-7148332 I2D: score=8 STRING: ENSP00000360266
    UNC119Q134322, 3MINT-63870 I2D: score=5 
    ARRB1P494071, 2, 3, ENSP000003771414EBI-713543,EBI-743313 MINT-7263136 I2D: score=3 STRING: ENSP00000377141
    ARRB2P321212, 3, ENSP000002692604MINT-7263161 I2D: score=6 STRING: ENSP00000269260
    GTF3C1Q127892, 3, ENSP000003485104MINT-63869 I2D: score=5 STRING: ENSP00000348510
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS7826642
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with MAPK10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MAPK10
      Browse compounds at ApexBio 

    Compounds for MAPK10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS JNK 6oSelective JNK inhibitor[894804-07-0]
    SP 600125Novel and selective JNK inhibitor[129-56-6]
    TCS JNK 5aSelective inhibitor of JNK2 and JNK3[312917-14-9]
    SU 3327Selective JNK inhibitor[40045-50-9]
    BI 78D3 Selective, competitive JNK inhibitor [883065-90-5]

    3 HMDB Compounds for MAPK10    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for MAPK10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for MAPK10 gene (see all 137)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 98,059 89.7 199 9518660 (3), 8943229 (2), 10486268 (2), 12151059 (2) (see all 99)
    tyrosine 85.2 623 1663789 (5), 9087451 (4), 1321821 (4), 8398135 (4) (see all 99)
    sb 203580 82 24 10381381 (1), 18404520 (1), 19726280 (1), 11018764 (1) (see all 21)
    threonine 77.3 134 1334998 (2), 8388132 (2), 8389470 (2), 8645201 (2) (see all 99)
    cl 100 75.6 14 8390041 (5), 11063877 (1), 8670865 (1), 8168826 (1) (see all 7)
    wortmannin 75.4 90 9133538 (4), 10645245 (3), 9196057 (3), 7945234 (2) (see all 56)
    phosphatidylinositol 73.7 125 15187085 (4), 10452557 (3), 11384880 (3), 9440544 (2) (see all 95)
    ly294002 70.3 29 10195934 (1), 10623881 (1), 14635227 (1), 16730650 (1) (see all 27)
    sp 600125 69.4 3 17078934 (1), 12589827 (1), 18377285 (1)
    serine 69.1 91 8388132 (2), 9010681 (2), 8645263 (2), 1849075 (1) (see all 76)



    Find genes that share compounds with MAPK10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for MAPK10 gene (4 alternative transcripts): 
    NM_002753.3  NM_138980.2  NM_138981.2  NM_138982.2  

    Unigene Cluster for MAPK10:

    Mitogen-activated protein kinase 10
    Hs.125503  [show with all ESTs]
    Unigene Representative Sequence: NM_138980
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35):
    ENST00000395169(uc003hpn.3 uc011ccw.2 uc003hpo.3 uc003hpp.3 uc010ikg.3 uc003hpr.3 uc003hps.3 uc003hpt.3 uc003hpu.3 uc003hpv.3)
    ENST00000395157 ENST00000359221 ENST00000310816 ENST00000361569 ENST00000508262
    ENST00000395160 ENST00000395166 ENST00000515400 ENST00000489368 ENST00000472236
    ENST00000468020 ENST00000479377 ENST00000486985 ENST00000513839(uc010ikh.1)
    ENST00000430389 ENST00000512017 ENST00000475679
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAPK10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK10 (see all 66):
    hsa-miR-193a-3p hsa-miR-128 hsa-miR-759 hsa-miR-629 hsa-miR-642b hsa-miR-130b hsa-miR-193b hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAPK10 3' UTR sequence
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    OriGene ORF clones in mouse, rat for MAPK10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK10 (NM_002753)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK10
    Addgene plasmids for MAPK10 
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK10
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      QuantiTect SYBR Green Assays in human, mouse, rat MAPK10
      QuantiFast Probe-based Assays in human, mouse, rat MAPK10

    Additional mRNA sequence: 

    AK057723.1 AK091104.1 AK124791.1 AK225974.1 AK294125.1 AK307129.1 BC022492.1 BC035057.1 
    BC051731.1 BC065516.1 U07620.1 U34819.1 U34820.1 

    Selected DOTS entries (see all 32):

    DT.121233059  DT.95269048  DT.314110  DT.314109  DT.121233006  DT.100786937  DT.101980289  DT.101980290 
    DT.75138142  DT.75157890  DT.121233067  DT.404901  DT.121233050  DT.100786932  DT.121233022  DT.40118124 
    DT.121232942  DT.121232975  DT.121232977  DT.121232980  DT.121232981  DT.121232990  DT.121233001  DT.121233023 

    Selected AceView cDNA sequences (see all 127):

    AI571813 AI278327 AA885300 AA460306 CB152200 BE855739 AK091104 BM714980 
    NM_002753 BF856752 BU607957 CB068524 NM_138980 CA393818 Z38358 CB069799 
    BM700156 AW571730 BE702577 BX088782 BM704479 BQ188297 F10604 U34819 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAPK10 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
    SP1:        -           -           -           -     -                 -                       -           -                       -                     
    SP2:        -           -                       -     -                 -                       -           -                       -                     
    SP3:                    -                       -     -                 -                       -           -                       -                     
    SP4:                    -           -           -     -                 -                       -           -                       -                     
    SP5:                    -           -           -     -                 -     -                 -     -                             -                     


    ECgene alternative splicing isoforms for MAPK10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAPK10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAGGGGGA
    MAPK10 Expression
    About this image


    MAPK10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+BMP4-induced E15 cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
    MAPK10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125503

    UniProtKB/Swiss-Prot: MK10_HUMAN, P53779
    Tissue specificity: Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas,
    cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK10: 
              Antiviral Response in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAPK10 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk101 , 5 mitogen-activated protein kinase 101, 5 91.74(n)1
    99.57(a)1
      5 (49.61 cM)5
    264141  NM_001081567.11  NP_001075036.11 
     1029123545 
    chicken
    (Gallus gallus)
    Aves MAPK101 mitogen-activated protein kinase 10 86.85(n)
    98.28(a)
      422592  XM_004941103.1  XP_004941160.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK106
    mitogen-activated protein kinase 10
    98(a)
    1 ↔ 1
    5(44632862-44725470)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.138732 Transcribed sequence with strong similarity to protein more 85.62(n)    BX741702.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapk101 mitogen-activated protein kinase 10 81.26(n)
    95.45(a)
      569698  NM_001037701.1  NP_001032790.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bsk3 JNK cascade protein serine/threonine
    kinase
    78(a)   2 31B3   --
    worm
    (Caenorhabditis elegans)
    Secernentea jnk-13 MAP kinase 70(a)
    (best of 5)
      IV(6957865-6963780)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HOG16
    Mitogen-activated protein kinase involved in osmor...
    34(a)
    1 → many
    XII(371620-372927) YLR113W


    ENSEMBL Gene Tree for MAPK10 (if available)
    TreeFam Gene Tree for MAPK10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK10 gene
    MAPK92  MAPK122  MAPK132  MAPK112  MAPK142  MAPK82  
    Selected SIMAP similar genes for MAPK10 using alignment to 15 protein entries:     MK10_HUMAN (see all proteins) (see all similar genes):
    MAPK8    MAPK9    MAPK11    MAPK14    MAPK13    DKFZp686O0215
    MAPK1    DYRK4    TXK    MAPK12    MAPK3    DKFZp686M02159
    NLK    MAPK7    CDC2L1    CDK11B    CDK5    CDK4

    Find genes that share paralogs with MAPK10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for MAPK10 (see all 7965)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381652031,2
    --82679764(+) GTTTAA/CTCTGA 4 -- ds50010--------
    rs25756751,2
    C,F,A,H--82679765(-) CTCAGA/GGTAAA 4 -- ds500124Minor allele frequency- G:0.22NS EA NA WA CSA 2766
    rs1896335831,2
    --82679875(+) GCTGAC/TGAAAT 4 -- ds50010--------
    rs1834098811,2
    --82679883(+) AATTCC/TCCTTG 4 -- ds50010--------
    rs1878124391,2
    --82679905(+) AAAGCA/GGCTTC 4 -- ds50010--------
    rs76999781,2
    C,F,A,H--82679931(+) AATCCA/CATGTG 4 -- ds500127Minor allele frequency- N:0.00NS EA NA WA CSA 2978
    rs2021096451,2
    C--82680032(+) AGAAG-/TTTTTA 4 -- ds50010--------
    rs745541751,2
    C--82680036(+) GTTTTA/TAAAAA 4 -- ds50010--------
    rs3730357271,2
    C--82680036(+) GTTTT-/A/TA  
            
    AAAAA
    4 -- ds50010--------
    rs3712102551,2
    C--82680037(+) TTTTT-/A/A   
      A
    /T/TA
    AAAAA
    4 -- ds50011NA 2

    HapMap Linkage Disequilibrium report for MAPK10 (86936276 - 87186276 bp, first 250kb of MAPK10)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAPK10 (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv5249CNV Deletion18987735
    dgv25e194CNV Deletion18987734
    esv2727930CNV Deletion23290073
    esv2727933CNV Deletion23290073
    esv2727931CNV Deletion23290073
    esv2670758CNV Deletion23128226
    esv2422128CNV Deletion20811451
    esv2727932CNV Deletion23290073
    esv2678617CNV Deletion23128226
    nsv4408CNV Insertion18451855

    Human Gene Mutation Database (HGMD): MAPK10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK10
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602897    OMIM disorders: --

    UniProtKB/Swiss-Prot: MK10_HUMAN, P53779
  • Note=A chromosomal aberration involving MAPK10 has been found in a single patient with pharmacoresistant
    epileptic encephalopathy. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation

  • 5 diseases for MAPK10:    
    About MalaCards
    lennox-gastaut syndrome    opioid abuse    congenital insensitivity to pain with anhidrosis    coffin-lowry syndrome
    anhidrosis


    Find genes that share disorders with MAPK10           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MAPK10 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paired helical filament 47.7 2 8282104 (1), 8734909 (1)
    tumors 39.8 97 9989833 (6), 12960139 (6), 10956414 (5), 11149601 (3) (see all 59)
    necrosis 39.7 15 12853971 (1), 19558546 (1), 10501211 (1), 9029150 (1) (see all 15)
    pheochromocytoma 38.7 7 7953555 (1), 7566349 (1), 9507116 (1), 16248892 (1) (see all 6)
    papillary thyroid cancer 37.8 6 11742320 (1), 18018556 (1), 18018555 (1), 11994395 (1)
    cancer 33.9 48 15298620 (3), 11309815 (1), 12149254 (1), 12419831 (1) (see all 44)
    shock 30.1 27 7759569 (3), 8389721 (2), 7585624 (2), 8307152 (2) (see all 16)
    myeloid leukemia 28.8 3 15339853 (2), 16972261 (1)
    neoplastic transformation 28.4 5 8058319 (2), 19347614 (1), 16302268 (1), 9765202 (1)
    breast cancer 25.7 43 11897507 (3), 12525252 (2), 9119990 (2), 10216485 (2) (see all 32)

    Genetic Association Database (GAD): MAPK10
    Human Genome Epidemiology (HuGE) Navigator: MAPK10 (2 documents)

    Export disorders for MAPK10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAPK10 gene, integrated from 10 sources (see all 2118):
    (articles sorted by number of sources associating them with MAPK10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Selective interaction of JNK protein kinase isoforms with transcription factors. (PubMed id 8654373)1, 2, 3, 9 Gupta S.... Davis R.J. (EMBO J. 1996)
    2. Truncation of the CNS-expressed JNK3 in a patient with a severe developmental epileptic encephalopathy. (PubMed id 16249883)1, 2, 9 Shoichet S.A....Kalscheuer V.M. (Hum. Genet. 2006)
    3. Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. (PubMed id 15693750)1, 2, 9 Jagadish N.... Suri A. (Biochem. J. 2005)
    4. Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1. (PubMed id 10715136)1, 2, 9 Lisnock J.... LoGrasso P. (Biochemistry 2000)
    5. p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. (PubMed id 7826642)1, 2, 9 Mohit A.A.... Miller C.A. (Neuron 1995)
    6. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    7. Visual and both non-visual arrestins in their 'inactive' conformation bind JNK3 and Mdm2 and relocalize them from the nucleus to the cytoplasm. (PubMed id 16737965)1, 2 Song X.... Gurevich V.V. (J. Biol. Chem. 2006)
    8. Neuroprotection by histone deacetylase-related protein. (PubMed id 16611996)1, 2 Morrison B.E.... D'Mello S.R. (Mol. Cell. Biol. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5602 HGNC: 6872 AceView: MAPK10 Ensembl:ENSG00000109339 euGenes: HUgn5602
    ECgene: MAPK10 Kegg: 5602 H-InvDB: MAPK10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAPK10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAPK10 gene:
    Search GeneIP for patents involving MAPK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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