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Aliases for MAPK10 Gene

Aliases for MAPK10 Gene

  • Mitogen-Activated Protein Kinase 10 2 3
  • PRKM10 3 4 6
  • JNK3 3 4 6
  • Stress-Activated Protein Kinase JNK3 3 4
  • Stress-Activated Protein Kinase 1b 3 4
  • C-Jun N-Terminal Kinase 3 3 4
  • MAP Kinase P49 3F12 3 4
  • MAP Kinase 10 3 4
  • EC 2.7.11.24 4 64
  • MAPK 10 3 4
  • SAPK1b 3 4
  • JNK3A 3 4
  • Stress Activated Protein Kinase Beta 3
  • JNK3 Alpha Protein Kinase 3
  • EC 2.7.11 64
  • P54bSAPK 3
  • P493F12 3

External Ids for MAPK10 Gene

Previous Symbols for MAPK10 Gene

  • PRKM10

Summaries for MAPK10 Gene

Entrez Gene Summary for MAPK10 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAPK10 Gene

MAPK10 (Mitogen-Activated Protein Kinase 10) is a Protein Coding gene. Diseases associated with MAPK10 include coffin-lowry syndrome and opioid abuse. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include MAP kinase kinase activity and JUN kinase activity. An important paralog of this gene is MAPK11.

UniProtKB/Swiss-Prot for MAPK10 Gene

  • Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).

Tocris Summary for MAPK10 Gene

  • MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions. Six groups of MAPK have so far been identified: Extracellular signal-regulated kinases (ERK1, ERK2), c-Jun N-terminal kinases (JNKs), p38 isoforms (MAPK11, MAPK12, MAPK13, MAPK14), ERK5 (MAPK7), ERK3 (MAPK6) and ERK4 (MAPK4) and ERK7/8 (MAPK15). ERK 1 and ERK 2 transduce signals from growth factors and are key in regulating differentiation and proliferation in many cell types. Upon activation by MEK, ERK1 and 2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as p90 RSK. JNK 1,2 and 3 (sometimes known as SAPKs or stress-activated kinases) and the p38 MAPKs (alpha-, beta-, delta and gamma- isoforms) are activated by UV irradiation, inflammatory cytokines and hyperosmolarity. The p38 MAPKs are also activated by lipopolysaccharide. Dysregulation of MAPK kinase pathways has been associated with various diseases including cancer (ERK), neurodegeneration (JNK) and inflammation (p38).

Gene Wiki entry for MAPK10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK10 Gene

Genomics for MAPK10 Gene

Genomic Location for MAPK10 Gene

Start:
86,012,299 bp from pter
End:
86,594,131 bp from pter
Size:
581,833 bases
Orientation:
Minus strand

Genomic View for MAPK10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK10 Gene

Regulatory Elements for MAPK10 Gene

Transcription factor binding sites by QIAGEN in the MAPK10 gene promoter:

Proteins for MAPK10 Gene

  • Protein details for MAPK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53779-MK10_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 10
    Protein Accession:
    P53779
    Secondary Accessions:
    • A6NFS3
    • A6NG28
    • B3KQ94
    • Q15707
    • Q49AP1

    Protein attributes for MAPK10 Gene

    Size:
    464 amino acids
    Molecular mass:
    52585 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MAPKBP1 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with HDAC9. Interacts with ARRB2; the interaction enhances MAPK10 activation by MAP3K5. Interacts with SARM1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for MAPK10 Gene

    Alternative splice isoforms for MAPK10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK10 Gene

Proteomics data for MAPK10 Gene at MOPED

Post-translational modifications for MAPK10 Gene

  • Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro.
  • Palmitoylation regulates subcellular location and axonal development.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys204

Domains for MAPK10 Gene

Gene Families for MAPK10 Gene

UniProtKB/Swiss-Prot:

MK10_HUMAN
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases:
    • P53779
  • Contains 1 protein kinase domain.:
    • P53779
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.:
    • P53779
genes like me logo Genes that share domains with MAPK10: view

Function for MAPK10 Gene

Molecular function for MAPK10 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by HDAC9.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).

Enzyme Numbers (IUBMB) for MAPK10 Gene

Gene Ontology (GO) - Molecular Function for MAPK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004705 JUN kinase activity ISS 8654373
GO:0004707 MAP kinase activity --
GO:0004708 MAP kinase kinase activity TAS 7826642
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with MAPK10: view
genes like me logo Genes that share phenotypes with MAPK10: view

Animal Models for MAPK10 Gene

MGI Knock Outs for MAPK10:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for MAPK10 Gene

Localization for MAPK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK10 Gene

Cytoplasm. Membrane; Lipid-anchor. Nucleus. Mitochondrion. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK10 Gene COMPARTMENTS Subcellular localization image for MAPK10 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
plasma membrane 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MAPK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with MAPK10: view

Pathways for MAPK10 Gene

genes like me logo Genes that share pathways with MAPK10: view

Pathways by source for MAPK10 Gene

Gene Ontology (GO) - Biological Process for MAPK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade --
GO:0000187 activation of MAPK activity TAS 7826642
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MAPK10: view

Compounds for MAPK10 Gene

(5) Tocris Compounds for MAPK10 Gene

Compound Action Cas Number
BI 78D3 Selective, competitive JNK inhibitor [883065-90-5]
SP 600125 Novel and selective JNK inhibitor [129-56-6]
SU 3327 Selective JNK inhibitor [40045-50-9]
TCS JNK 5a Selective inhibitor of JNK2 and JNK3 [312917-14-9]
TCS JNK 6o Selective JNK inhibitor [894804-07-0]

(3) HMDB Compounds for MAPK10 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(1) Drugbank Compounds for MAPK10 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine
target

(137) Novoseek inferred chemical compound relationships for MAPK10 Gene

Compound -log(P) Hits PubMed IDs
pd 98,059 89.7 110
tyrosine 85.2 221
sb 203580 82 21
threonine 77.3 107
cl 100 75.6 11
genes like me logo Genes that share compounds with MAPK10: view

Transcripts for MAPK10 Gene

Unigene Clusters for MAPK10 Gene

Mitogen-activated protein kinase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9:
SP10:
SP11: -

Relevant External Links for MAPK10 Gene

GeneLoc Exon Structure for
MAPK10
ECgene alternative splicing isoforms for
MAPK10

Expression for MAPK10 Gene

mRNA expression in normal human tissues for MAPK10 Gene

mRNA differential expression in normal tissues according to GTEx for MAPK10 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.6), Brain - Cortex (5.1), and Brain - Anterior cingulate cortex (BA24) (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK10 Gene

SOURCE GeneReport for Unigene cluster for MAPK10 Gene Hs.125503

mRNA Expression by UniProt/SwissProt for MAPK10 Gene

P53779-MK10_HUMAN
Tissue specificity: Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney
genes like me logo Genes that share expressions with MAPK10: view

Orthologs for MAPK10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPK10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK10 36
  • 99.86 (n)
  • 100 (a)
MAPK10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK10 36
  • 94.13 (n)
  • 100 (a)
MAPK10 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK10 36
  • 93.89 (n)
  • 98.06 (a)
MAPK10 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk10 36
  • 91.74 (n)
  • 99.57 (a)
Mapk10 16
Mapk10 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPK10 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK10 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk10 36
  • 91.67 (n)
  • 99.35 (a)
chicken
(Gallus gallus)
Aves MAPK10 36
  • 86.85 (n)
  • 98.28 (a)
MAPK10 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK10 37
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk10 36
  • 85.89 (n)
  • 97.85 (a)
Str.13873 36
zebrafish
(Danio rerio)
Actinopterygii mapk10 36
  • 81.26 (n)
  • 95.45 (a)
mapk10 37
  • 93 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bsk 37
  • 77 (a)
OneToMany
bsk 38
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea jnk-1 37
  • 57 (a)
OneToMany
Y51B9A.9 38
  • 35 (a)
jnk-1 38
  • 70 (a)
C49C3.10a 38
  • 32 (a)
F09C12.2 38
  • 35 (a)
C49C3.10b 38
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOG1 37
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 61 (a)
OneToMany
Species with no ortholog for MAPK10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK10 Gene

ENSEMBL:
Gene Tree for MAPK10 (if available)
TreeFam:
Gene Tree for MAPK10 (if available)

Paralogs for MAPK10 Gene

Paralogs for MAPK10 Gene

genes like me logo Genes that share paralogs with MAPK10: view

Variants for MAPK10 Gene

Sequence variations from dbSNP and Humsavar for MAPK10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs958 -- 86,016,721(+) GAGCC(A/C/G/T)TGAGG utr-variant-3-prime
rs1201 -- 86,015,315(+) GAAAG(A/G)AAGTT utr-variant-3-prime
rs1202 -- 86,015,255(+) ACTGG(C/T)ATGGC utr-variant-3-prime
rs3527 -- 86,017,027(-) AATGT(A/G)TATTT utr-variant-3-prime
rs385484 -- 86,109,644(-) ctaaa(C/G)gccca intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAPK10 Gene

Variant ID Type Subtype PubMed ID
esv1427548 CNV Insertion 17803354
nsv511259 CNV Loss 21212237
esv2727930 CNV Deletion 23290073
esv2670758 CNV Deletion 23128226
nsv517318 CNV Loss 19592680
nsv10529 CNV Loss 18304495
esv2422128 CNV Deletion 20811451
nsv442912 CNV CNV 18776908
nsv513143 CNV Loss 21212237
esv2727931 CNV Deletion 23290073
esv2678617 CNV Deletion 23128226
nsv471766 CNV Loss 16327809
esv26690 CNV Loss 19812545
nsv514230 CNV Loss 21397061
dgv660n27 CNV Loss 19166990
nsv818248 CNV Loss 17921354
nsv879521 CNV Loss 21882294
nsv820309 CNV Gain 19587683
nsv4408 CNV Insertion 18451855
dgv25e194 CNV Deletion 18987734
esv2727932 CNV Deletion 23290073
esv5249 CNV Deletion 18987735
nsv291104 CNV Loss 16902084
esv2727933 CNV Deletion 23290073
dgv1648e1 CNV Complex 17122850
essv19743 CNV CNV 17122850
nsv515925 CNV Loss 19592680
esv29871 CNV Gain 19812545
nsv461574 CNV Loss 19166990

Relevant External Links for MAPK10 Gene

HapMap Linkage Disequilibrium report
MAPK10
Human Gene Mutation Database (HGMD)
MAPK10

Disorders for MAPK10 Gene

UniProtKB/Swiss-Prot

MK10_HUMAN
  • Note=A chromosomal aberration involving MAPK10 has been found in a single patient with pharmacoresistant epileptic encephalopathy. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. {ECO:0000269 PubMed:16249883}.

(93) Novoseek inferred disease relationships for MAPK10 Gene

Disease -log(P) Hits PubMed IDs
paired helical filament 47.7 2
tumors 39.8 77
necrosis 39.7 15
pheochromocytoma 38.7 6
papillary thyroid cancer 37.8 4

Relevant External Links for MAPK10

Genetic Association Database (GAD)
MAPK10
Human Genome Epidemiology (HuGE) Navigator
MAPK10
genes like me logo Genes that share disorders with MAPK10: view

Publications for MAPK10 Gene

  1. Selective interaction of JNK protein kinase isoforms with transcription factors. (PMID: 8654373) Gupta S. … Davis R.J. (EMBO J. 1996) 2 3 4 23
  2. p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. (PMID: 7826642) Mohit A.A. … Miller C.A. (Neuron 1995) 3 4 23
  3. Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1. (PMID: 10715136) Lisnock J. … LoGrasso P. (Biochemistry 2000) 3 4 23
  4. Truncation of the CNS-expressed JNK3 in a patient with a severe developmental epileptic encephalopathy. (PMID: 16249883) Shoichet S.A. … Kalscheuer V.M. (Hum. Genet. 2006) 3 4 23
  5. Cone arrestin binding to JNK3 and Mdm2: conformational preference and localization of interaction sites. (PMID: 17680991) Song X. … Gurevich V.V. (J. Neurochem. 2007) 3 23

Products for MAPK10 Gene

Sources for MAPK10 Gene

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