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MAPK1 Gene

protein-coding   GIFtS: 75
GCID: GC22M022108

Mitogen-Activated Protein Kinase 1


(Previous symbols: PRKM2, PRKM1)
  See MAPK1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase 11 2     p42-MAPK2 3
PRKM11 2 3 5     EC 2.7.11.243 8
PRKM21 2 3     ERK2
ERK22 3 5     MAPK22
Extracellular Signal-Regulated Kinase 22 3     P42MAPK2
Mitogen-Activated Protein Kinase 22 3     p382
ERK-22 3     p402
ERT12 3     p412
MAP Kinase 12 3     p41mapk2
MAP Kinase 22 3     Protein Tyrosine Kinase ERK22
MAP Kinase Isoform P422 3     MAPK 13
MAPK 22 3     EC 2.7.118

External Ids:    HGNC: 68711   Entrez Gene: 55942   Ensembl: ENSG000001000307   OMIM: 1769485   UniProtKB: P284823   

Export aliases for MAPK1 gene to outside databases

Previous GC identifers: GC22M018815 GC22M020441 GC22M005071


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAPK1 Gene:
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated
kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety
of cellular processes such as proliferation, differentiation, transcription regulation and development. The
activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase
translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also
suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded
protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct
functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs,
have been reported for this gene. (provided by RefSeq, Jan 2014)

GeneCards Summary for MAPK1 Gene:
MAPK1 (mitogen-activated protein kinase 1) is a protein-coding gene. Diseases associated with MAPK1 include retrograde amnesia, and distal 22q11.2 microdeletion syndrome. GO annotations related to this gene include phosphatase binding and protein serine/threonine kinase activity. An important paralog of this gene is MAPK4.

UniProtKB/Swiss-Prot: MK01_HUMAN, P28482
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They
participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular
context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and
differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK
cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in
differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been
discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the
regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in
other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis.
Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome
processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the
fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2,
BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or
STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation
(such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein
kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,
RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are
other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets,
thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation.
May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1,
leading to PML degradation
Function: Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression
of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3,
OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity

summary for MAPK1 Gene:
Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate
intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol
esters. They are expressed in all tissues, at varying levels. Upon activation by MEK, ERK1 and 2 translocate
to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as
p90 RSK.

Gene Wiki entry for MAPK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAPK1 gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): MAPK1 promoter sequence
   Search Chromatin IP Primers for MAPK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAPK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.2

MAPK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPK1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M022108:  view genomic region     (about GC identifiers)

Start:
22,108,789 bp from pter      End:
22,221,970 bp from pter
Size:
113,182 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MK01_HUMAN, P28482 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase 1  
Size: 360 amino acids; 41390 Da
Cofactor: Magnesium (By similarity)
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes. Binds to HIV-1 Nef
through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARHGEF2,
ARRB2, DAPK1 (via death domain), HSF4, IER3, IPO7, DUSP6, NISCH, SGK1, and isoform 1 of NEK2. Interacts
(phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads to
nuclear location and MAPK1 activation. Interacts with MORG1, PEA15 and MKNK2 (By similarity). MKNK2 isoform 1
binding prevents from dephosphorylation and inactivation (By similarity). Interacts with DCC (By similarity). The
phosphorylated form interacts with PML (isoform PML-4)
Sequence caution: Sequence=CAA77753.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for MAPK1 (see all 34):
1PME (3D)        1TVO (3D)        1WZY (3D)        2OJG (3D)        2OJI (3D)        2OJJ (3D)    
Secondary accessions: A8CZ64
Alternative splicing: 2 isoforms:  P28482-1   P28482-2   

Explore the universe of human proteins at neXtProt for MAPK1: NX_P28482

Explore proteomics data for MAPK1 at MOPED

Post-translational modifications: 

  • Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-185 and Tyr-187, which
    activates the enzyme. Undergoes regulatory phosphorylation on additional residues such as Ser-246 and Ser-248 in
    the kinase insert domain (KID) These phosphorylations, which are probably mediated by more than one kinase, are
    important for binding of MAPK1/ERK2 to importin-7 (IPO7) and its nuclear translocation. In addition,
    autophosphorylation of Thr-190 was shown to affect the subcellular localization of MAPK1/ERK2 as well.
    Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-187. Phosphorylation on
    Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. DUSP3 and
    DUSP6 dephosphorylate specifically MAPK1/ERK2 and MAPK3/ERK1 whereas DUSP9 dephosphorylates a broader range of
    MAPKs1
  • ISGylated (By similarity)1
  • Ubiquitination2 at Lys55, Lys203, Lys292
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAPK1 (P28482) (see all 33)
     LKYIHSA  RVAIKKI  GCILAEM  VLHRDLK 


    See MAPK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002736.3  NP_620407.1  

    ENSEMBL proteins: 
     ENSP00000215832   ENSP00000381803   ENSP00000440842  
    Reactome Protein details: P28482

    MAPK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAPK1 Protein
    R&D Systems Recombinant & Natural Proteins for MAPK1 (ERK2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MAPK1
    OriGene Protein Over-expression Lysate for MAPK1
    OriGene MassSpec for MAPK1
    OriGene Custom Protein Services for MAPK1
    GenScript Custom Purified and Recombinant Proteins Services for MAPK1
    Novus Biologicals MAPK1 Proteins
    Novus Biologicals MAPK1 Lysates
    Sino Biological Recombinant Protein for MAPK1
    Sino Biological Cell Lysate for MAPK1
    ProSpec Recombinant Protein for MAPK1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MAPK1 

    MAPK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAPK1
    R&D Systems Antibodies for MAPK1 (ERK2)
    Cell Signaling Technology (CST) Antibodies for MAPK1  (ERK2)
    OriGene Antibodies for MAPK1
    OriGene Custom Antibody Services for MAPK1
    Novus Biologicals MAPK1 Antibodies
    Abcam antibodies for MAPK1 (P27361, P28482)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for MAPK1
    LSBio Antibodies in human, mouse, rat for MAPK1

    MAPK1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of MAPK1
    OriGene Custom Assay Services for MAPK1
    R&D Systems ELISAs for MAPK1 (ERK2)         (see all)
    GenScript Custom Assay Services for MAPK1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAPK1 (ERK2)
    Enzo Life Sciences assays for MAPK1
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for MAPK1:  
                        AKT/ERK Activation InstantOne ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAPK: Mitogen-activated protein kinase cascade / Kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase 1
    ERK subfamily
    Mitogen-activated protein kinases

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR003527 MAP_kinase_CS

    Graphical View of Domain Structure for InterPro Entry P28482

    ProtoNet protein and cluster: P28482

    2 Blocks protein domains:
    IPB003527 MAP kinase
    IPB008349 ERK1/2 MAP kinase signature


    UniProtKB/Swiss-Prot: MK01_HUMAN, P28482
    Domain: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAPK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MK01_HUMAN, P28482
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They
    participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular
    context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and
    differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK
    cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in
    differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been
    discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the
    regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in
    other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis.
    Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome
    processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the
    fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2,
    BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or
    STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation
    (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein
    kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,
    RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are
    other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets,
    thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation.
    May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1,
    leading to PML degradation
    Function: Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression
    of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3,
    OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-185 and Tyr-187 in response to external
    stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes
    dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates.
    Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and
    MAP2K2/MEK2. Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9. Inactivated by pyrimidylpyrrole
    inhibitors

         Genatlas biochemistry entry for MAPK1:
    mitogen-activated protein kinase 1 (p40,p41),three isoforms,5.5kb highly expressed in forebrain,4.6kb,in
    skeletal,heart muscle and liver,2.8kb,skeletal,heart muscle,brain,activated and tyrosine phosphorylated in
    response to insulin NGF and other signals,widely involved in signal transduction,translocated to the nucleus
    after activation where it phosphorylate nuclear targets

         Enzyme Numbers (IUBMB): EC 2.7.11.241 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001784phosphotyrosine binding IEA--
    GO:0003677DNA binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15850461
    GO:0004707MAP kinase activity IEA--
         
    Find genes that share ontologies with MAPK1           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for MAPK1:
     Decreased substrate adherent c  Decreased telomerase activity  Decreased viability with carbo  Increased cell death in HCT116 
     Synthetic lethal with c-Myc af  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 12 alleles(MGI details for Mapk1) (see all 17):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  muscle  nervous system  reproductive system  respiratory system 

    Find genes that share phenotypes with MAPK1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MAPK1: Mapk1tm2Hed Mapk1tm1Melo Mapk1tm1.1Kuta Mapk1tm2Moga Mapk1tm1Moga

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAPK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAPK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAPK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAPK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAPK1:
    hsa-mir-92b-3p (MIRT040549), hsa-mir-199a-3p (MIRT003983), hsa-mir-335-5p (MIRT006447), hsa-mir-30a-5p (MIRT028452), hsa-mir-28-5p (MIRT006418), hsa-mir-15b-5p (MIRT046445), hsa-mir-769-5p (MIRT039161), hsa-let-7b-5p (MIRT052280), hsa-mir-766-3p (MIRT039037), hsa-mir-320a (MIRT007093)

    Block miRNA regulation of human, mouse, rat MAPK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK1 (see all 158):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-132* hsa-miR-520f hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-3916
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAPK1
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAPK1

    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK1 (see all 13)
    OriGene ORF clones in mouse, rat for MAPK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK1 (NM_139012)
    Sino Biological Human cDNA Clone for MAPK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK1
    Addgene plasmids for MAPK1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAPK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAPK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12237) for MAPK1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MK01_HUMAN, P28482: Cytoplasm, cytoskeleton, spindle (By similarity). Nucleus. Cytoplasm, cytoskeleton,
    microtubule organizing center, centrosome. Cytoplasm. Note=Associated with the spindle during prometaphase and
    metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention.
    Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    endosome5
    golgi apparatus5
    mitochondrion5
    nucleus5
    plasma membrane5
    extracellular2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS19565474
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0005739mitochondrion TAS19565474

    Find genes that share ontologies with MAPK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAPK1 About   (see all 250)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF signaling pathway0.39
    Immune response BCR pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    Fc-epsilon receptor I signaling in mast cells0.34
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Transcription PPAR Pathway0.34
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Transcription Receptor mediated HIF regulation0.51
    mTOR signaling pathway0.34
    Translation Regulation activity of EIF20.47
    Insulin signaling pathway0.32
    3IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-7 Signaling Pathways0.90
    IL-9 Signaling Pathway0.42
    IL-21 Signaling Pathways0.90
    Immune response IL 9 signaling pathway0.42
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    4Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Development PDGF signaling via MAPK cascades0.41
    Apoptosis and survival Anti apoptotic action of membrane bound ESR10.35
    5G protein signaling Ras family GTPases in kinase cascades scheme
    G protein signaling Ras family GTPases in kinase cascades scheme 0.44
    Oncostatin M Signaling Pathway0.37
    MAPK Cascade0.44
    Activation of the AP-1 family of transcription factors0.00
    Immune response Oncostatin M signaling via MAPK in human cells0.39


    Find genes that share SuperPaths with MAPK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for MAPK1 (see all 14)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-17 Family Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAPK1 (see all 135)
        Molecular Mechanisms of Cancer
    eIF2 Pathway
    CDK5 Pathway
    NF-kappaB Activation by Viruses
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for MAPK1
        MAP Kinase Signaling

    Selected GeneGo (Thomson Reuters) Pathways for MAPK1 (see all 91)
        Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Immune response IL-9 signaling pathway

    Selected BioSystems Pathways for MAPK1 (see all 108)
        Osteopontin Signaling
    MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Angiogenesis
    Focal Adhesion

    4 Sino Biological Pathways for MAPK1
        TNF Signaling
    EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for MAPK1 (see all 24)
        Advanced glycosylation endproduct receptor signaling
    Regulation of HSF1-mediated heat shock response
    FCERI mediated MAPK activation
    Signal transduction by L1
    Golgi Cisternae Pericentriolar Stack Reorganization

    Selected PharmGKB Pathways for MAPK1 (see all 8)
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Diuretics Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for MAPK1) (see all 76):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK1 (see all 28): 
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAPK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAPK1 (P284821, 2, 3 ENSP000002158324) via UniProtKB, MINT, STRING, and/or I2D (see all 821)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRJQ129131, 2, 3, ENSP000004000104EBI-959949,EBI-2264500 MINT-7144682 MINT-7144769 MINT-7144721 MINT-7046457 MINT-7046645 MINT-7144737 MINT-7144832 I2D: score=1 STRING: ENSP00000400010
    PTPN7P352361, 2, 3, ENSP000003562484EBI-959949,EBI-2265723 MINT-8208655 MINT-8208672 MINT-8208589 MINT-8208635 I2D: score=5 STRING: ENSP00000356248
    DUSP1P285621, 2, 3, ENSP000002392234EBI-959949,EBI-975493 MINT-8291556 MINT-8291551 MINT-8217047 I2D: score=6 STRING: ENSP00000239223
    ENSG00000235030P466952, 3, ENSP000004122834MINT-2835582 I2D: score=4 STRING: ENSP00000412283
    ENSG00000237155P466952, 3, ENSP000003979564MINT-2835582 I2D: score=4 STRING: ENSP00000397956
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 72):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--
    GO:0000187activation of MAPK activity TAS--
    GO:0000189MAPK import into nucleus IEA--
    GO:0002224toll-like receptor signaling pathway TAS--

    Find genes that share ontologies with MAPK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MAPK1
      Browse compounds at ApexBio 

    Compounds for MAPK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    XMD 8-92Selective ERK5/BMK1 inhibitor[1234480-50-2]
    FR 180204Selective ERK inhibitor[865362-74-9]
    PluripotinDual ERK1/RasGAP inhibitor. Maintains ESC self-renewal[839707-37-8]
    TCS ERK 11ePotent and selective ERK2 inhibitor[896720-20-0]

    4 HMDB Compounds for MAPK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    SumatriptanImigran (see all 4)103628-46-2--

    Selected DrugBank Compounds for MAPK1 (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    IsoproterenolEpinephrine Isopropyl Homolog (see all 14)7683-59-2targetinducer20732414 12963636 13679574 15689414 15292328 15138589
    Phosphonothreonine-- --target--17139284 17016423 10592235
    Arsenic trioxideAcide Arsenieux [French] (see all 11)1327-53-3targetinducer12529330 12426127
    (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione-- --target--10592235
    (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE-- --target--10592235
    (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE-- --target--10592235
    4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE-- --target--10592235
    5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE-- --target--10592235
    N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE-- --target--10592235
    N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for MAPK1 gene (see all 138)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 98,059 96.1 1138 19494198 (3), 10852350 (3), 11089552 (3), 14506750 (3) (see all 99)
    sb 203580 93.9 703 11746502 (4), 18655782 (4), 15132853 (3), 12393894 (3) (see all 99)
    sp 600125 90.2 210 16699726 (2), 17311279 (2), 15964311 (2), 20432452 (2) (see all 99)
    ly294002 86.8 194 19956885 (2), 20517899 (2), 9850168 (2), 11483613 (2) (see all 99)
    tyrosine 85.9 929 10903909 (6), 10683437 (4), 10737896 (4), 9186005 (4) (see all 99)
    phosphatidylinositol 85.1 413 8798386 (3), 9632795 (3), 12444151 (3), 11420298 (3) (see all 99)
    ag 1478 83.3 88 19723115 (4), 11160627 (3), 15995627 (2), 11694531 (2) (see all 63)
    wortmannin 81.2 154 7498528 (5), 19800362 (3), 12444151 (2), 15110780 (2) (see all 99)
    u0126 81 40 16351709 (3), 12667551 (2), 15563545 (1), 17223661 (1) (see all 30)
    pd-184352 74.3 14 20145173 (2), 11728381 (1), 14566055 (1), 19492026 (1) (see all 10)



    Find genes that share compounds with MAPK1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for MAPK1 gene (2 alternative transcripts): 
    NM_002745.4  NM_138957.3  

    Unigene Cluster for MAPK1:

    Mitogen-activated protein kinase 1
    Hs.431850  [show with all ESTs]
    Unigene Representative Sequence: AL157438
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215832(uc002zvn.3) ENST00000491588 ENST00000398822(uc002zvo.3 uc010gtk.1)
    ENST00000544786
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAPK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAPK1 (see all 158):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-132* hsa-miR-520f hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-3916
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAPK1
    Predesigned siRNA for gene silencing in human, mouse, rat MAPK1
    Clone
    Products:
         
    OriGene clones in human, mouse for MAPK1 (see all 13)
    OriGene ORF clones in mouse, rat for MAPK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAPK1 (NM_139012)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAPK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAPK1
    Addgene plasmids for MAPK1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAPK1
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK1
      QuantiTect SYBR Green Assays in human, mouse, rat MAPK1
      Search QuantiFast Probe-based Assays in human, mouse, rat MAPK1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12237) for MAPK1 

    Additional mRNA sequence: 

    AK055080.1 AK057143.1 AK090869.1 AK295188.1 AK307615.1 AL157438.1 BC017832.1 BC099905.1 
    DQ399292.1 EF565108.1 Z11694.1 Z11695.1 

    Selected DOTS entries (see all 29):

    DT.100828664  DT.85104780  DT.100828661  DT.318194  DT.95232757  DT.100828658  DT.120665483  DT.120665553 
    DT.91794133  DT.120665550  DT.101962440  DT.100828663  DT.100828655  DT.100828666  DT.100759821  DT.101967870 
    DT.120665493  DT.120665561  DT.91778049  DT.95232759  DT.95248493  DT.100828659  DT.320781  DT.91778055 

    Selected AceView cDNA sequences (see all 622):

    N45337 AA936073 BM796918 BM977175 AI872237 BU616908 AA565292 BM828506 
    AV652097 CK429385 AW271813 BX430435 BG054502 AI243874 AI571445 CD674992 
    AA195999 BQ217431 F04825 AI962563 AI245957 CA418299 Z44325 AA280735 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAPK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAPK1 Expression
    About this image


    MAPK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MAPK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAPK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.431850
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAPK1 (see all 28): 
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAPK1
    OriGene qSTAR qPCR primer pairs in human, mouse for MAPK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAPK1
    QuantiTect SYBR Green Assays in human, mouse, rat MAPK1
    Search QuantiFast Probe-based Assays in human, mouse, rat MAPK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAPK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAPK1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mapk11 , 5 mitogen-activated protein kinase 11, 5 92.62(n)1
    99.44(a)1
      16 (10.53 cM)5
    264131  NM_001038663.11  NP_001033752.11 
     169833825 
    chicken
    (Gallus gallus)
    Aves MAPK11 mitogen-activated protein kinase 1 86.57(n)
    99.43(a)
      373953  NM_204150.1  NP_989481.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAPK16
    mitogen-activated protein kinase 1
    94(a)
    1 ↔ 1
    GL343282.1(1294534-1309924)
    African clawed frog
    (Xenopus laevis)
    Amphibia X59813.12   -- 80.87(n)    X59813.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mapk12 mitogen-activated protein kinase 1 79.94(n)   360144  AB030903.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG187323
    rl1
    rolled1 86(a)
    (best of 2)3
    66.09(n)1
    81.98(a)1
      33548881  NM_001015122.31  NP_001015122.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mpk-11 , 3 serine/threonine kinase (CDC2/CDC28
    subfamily)3
    mpk-11
    81(a)
    (best of 6)3
    68.04(n)1
    81.18(a)1
      III(4289194-4299892)3
    1755451  NM_001027412.31  NP_001022583.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FUS3(YBL016W)4
    KSS11
    Mitogen-activated serine/threonine protein kinase involved more4
    KSS11
    56.86(n)1
    53.82(a)1
      2(192451-193512)4
    8529311  NP_011554.31  8522654 
     NP_009537.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MPK61 MPK6 56.21(n)
    52.49(a)
      818982  NM_129941.3  NP_181907.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01545001 Os06g0154500 57.52(n)
    53.1(a)
      4340170  NM_001063381.1  NP_001056846.1 


    ENSEMBL Gene Tree for MAPK1 (if available)
    TreeFam Gene Tree for MAPK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAPK1 gene
    MAPK42  MAPK32  MAPK72  NLK2  MAPK152  MAPK62  
    Selected SIMAP similar genes for MAPK1 using alignment to 3 protein entries:     MK01_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O0215    MAPK3    MAPK7    MAPK14    NLK    MAPK4
    MAPK13    MAPK10    DKFZp686M02159    MAPK11    MAPK12    MAPK15
    MAPK8    MAPK9    CDK20    CDC2L1    CDC2L2    CDK11A

    Find genes that share paralogs with MAPK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAPK1 (see all 2564)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456759381,2
    --6059937(+) TGGGGG/TTCTGC 1 -- ds50010--------
    rs1383335401,2
    --6060005(+) CTGAAC/TGTGTT 1 -- ds50010--------
    rs617579851,2
    C,F--6060084(-) TCAGCG/AGTAGC 1 -- ds50017Minor allele frequency- A:0.19NS WA CSA 202
    rs617579841,2
    C,F--6060095(-) ATGGGC/TTTCTC 1 -- ds50016Minor allele frequency- T:0.04NS WA NA EA 454
    rs1864172941,2
    --6060096(+) AGAAGC/TCCATC 1 -- ds50010--------
    rs1419086781,2
    --6060097(+) GAAGCC/TCATCA 1 -- ds50010--------
    rs768514031,2
    F--6060117(+) GAAAAT/CGGGAC 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs584714251,2
    C,F--6060150(+) AAGATA/G/TATTAT 1 -- ds50013NS WA 212
    rs22760051,2
    C,F,A,H--6060162(+) CTGATT/GGCCTT 1 -- ds500124Minor allele frequency- G:0.13NS EA NA 2326
    rs1908308861,2
    --6060188(+) AACAGA/GGAAGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MAPK1 (22108789 - 22221970 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAPK1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv22e196CNV Deletion17116639
    dgv23e196CNV Deletion17116639
    esv2422338CNV Deletion17116639
    esv2675107CNV Deletion23128226
    esv2422374CNV Duplication17116639
    dgv20e196CNV Duplication17116639
    nsv3564CNV Insertion18451855
    dgv256n21CNV Loss19592680
    nsv510804CNV Loss20534489
    dgv4883n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): MAPK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAPK1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAPK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 176948    OMIM disorders: --

    12 diseases for MAPK1:    
    About MalaCards
    retrograde amnesia    distal 22q11.2 microdeletion syndrome    congenital insensitivity to pain with anhidrosis    anhidrosis
    frozen shoulder    ewing's family of tumors    mesangial proliferative glomerulonephritis    thyroid lymphoma
    corticobasal degeneration    trachoma    pancreatic cancer    breast cancer

    1 disease from the University of Copenhagen DISEASES database for MAPK1:
    Acquired immunodeficiency syndrome

    Find genes that share disorders with MAPK1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MAPK1 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 71.1 566 16125074 (7), 12727228 (6), 15854513 (5), 16338224 (5) (see all 99)
    necrosis 66.6 147 15640643 (2), 16737974 (2), 15003539 (2), 16672322 (2) (see all 99)
    cancer 66.3 193 15010817 (3), 16273204 (3), 10492251 (3), 15243131 (2) (see all 99)
    inflammation 59.1 67 15327816 (5), 16222708 (4), 18080320 (2), 11784793 (2) (see all 46)
    colon cancer 57.4 38 12865932 (2), 15037631 (2), 9354428 (2), 17220595 (2) (see all 29)
    breast cancer 52.4 146 19920183 (3), 12408764 (3), 19775288 (3), 18597688 (2) (see all 99)
    melanoma 50.4 111 18509361 (4), 17308088 (4), 12594806 (4), 15735667 (3) (see all 73)
    pancreatic cancer 49.3 66 11401480 (4), 19820417 (3), 15930308 (3), 19618718 (3) (see all 41)
    leukemia 47.7 65 14706142 (3), 19143758 (3), 18563362 (2), 20036724 (2) (see all 40)
    adenocarcinoma lung 46.9 15 15138593 (2), 17183064 (2), 16219134 (1), 19457446 (1) (see all 12)

    Genetic Association Database (GAD): MAPK1
    Human Genome Epidemiology (HuGE) Navigator: MAPK1 (26 documents)

    Export disorders for MAPK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for MAPK1 gene, integrated from 10 sources (see all 6122):
    (articles sorted by number of sources associating them with MAPK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. (PubMed id 12356731)1, 2, 9 Garcia J.... Porteu F. (EMBO J. 2002)
    2. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PubMed id 10224087)1, 2, 9 Todd J.L.... Denu J.M. (J. Biol. Chem. 1999)
    3. Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. (PubMed id 18794356)1, 2, 9 Vomastek T.... Nandicoori V.K. (Mol. Cell. Biol. 2008)
    4. A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. (PubMed id 19060905)1, 2, 9 Lorenz K.... Lohse M.J. (Nat. Med. 2009)
    5. Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer. (PubMed id 19628422)1, 4, 9 Murugan A.K....Tsuchida N. (Oral Oncol. 2009)
    6. ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA. (PubMed id 18211802)1, 2, 9 Fujishiro S.H....Kohno M. (Biochem. Biophys. Res. Commun. 2008)
    7. MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. (PubMed id 15241487)1, 2, 9 Domina A.M.... Craig R.W. (Oncogene 2004)
    8. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1, 4  ....Compston A. (Nature 2011)
    9. Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnover. (PubMed id 22033920)1, 2 Lim J.H.... Kao H.Y. (J. Biol. Chem. 2011)
    10. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5594 HGNC: 6871 AceView: MAPK1 Ensembl:ENSG00000100030 euGenes: HUgn5594
    ECgene: MAPK1 Kegg: 5594 H-InvDB: MAPK1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAPK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAPK1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Extracellular_signal-regulated_kinase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAPK1 gene:
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    GeneCards and IP:
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