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Aliases for MAPK1 Gene

Aliases for MAPK1 Gene

  • Mitogen-Activated Protein Kinase 1 2 3 5
  • Extracellular Signal-Regulated Kinase 2 3 4
  • Mitogen-Activated Protein Kinase 2 3 4
  • MAP Kinase Isoform P42 3 4
  • MAP Kinase 1 3 4
  • MAP Kinase 2 3 4
  • EC 2.7.11.24 4 63
  • P42-MAPK 3 4
  • MAPK 2 3 4
  • PRKM1 3 4
  • PRKM2 3 4
  • ERK-2 3 4
  • ERK2 3 4
  • ERT1 3 4
  • Protein Tyrosine Kinase ERK2 3
  • EC 2.7.11 63
  • P42MAPK 3
  • P41mapk 3
  • MAPK 1 4
  • MAPK2 3
  • P38 3
  • P40 3
  • ERK 3
  • P41 3

External Ids for MAPK1 Gene

Previous HGNC Symbols for MAPK1 Gene

  • PRKM2
  • PRKM1

Previous GeneCards Identifiers for MAPK1 Gene

  • GC22M018815
  • GC22M020441
  • GC22M022108
  • GC22M005071

Summaries for MAPK1 Gene

Entrez Gene Summary for MAPK1 Gene

  • This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

GeneCards Summary for MAPK1 Gene

MAPK1 (Mitogen-Activated Protein Kinase 1) is a Protein Coding gene. Diseases associated with MAPK1 include chromosome 22q11.2 deletion syndrome, distal and pertussis. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK3.

UniProtKB/Swiss-Prot for MAPK1 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation.

  • Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

Tocris Summary for MAPK1 Gene

  • Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.

Gene Wiki entry for MAPK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK1 Gene

Genomics for MAPK1 Gene

Regulatory Elements for MAPK1 Gene

Genomic Location for MAPK1 Gene

Chromosome:
22
Start:
21,754,500 bp from pter
End:
21,867,680 bp from pter
Size:
113,181 bases
Orientation:
Minus strand

Genomic View for MAPK1 Gene

Genes around MAPK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK1 Gene

Proteins for MAPK1 Gene

  • Protein details for MAPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28482-MK01_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 1
    Protein Accession:
    P28482
    Secondary Accessions:
    • A8CZ64

    Protein attributes for MAPK1 Gene

    Size:
    360 amino acids
    Molecular mass:
    41390 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds both upstream activators and downstream substrates in multimolecular complexes. Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARHGEF2, ARRB2, DAPK1 (via death domain), HSF4, IER3, IPO7, DUSP6, NISCH, SGK1, and isoform 1 of NEK2. Interacts (phosphorylated form) with CAV2 (Tyr-19-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with MORG1, PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with DCC (By similarity). The phosphorylated form interacts with PML (isoform PML-4). Interacts with STYX.
    SequenceCaution:
    • Sequence=CAA77753.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAPK1 Gene

    Alternative splice isoforms for MAPK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK1 Gene

Proteomics data for MAPK1 Gene at MOPED

Post-translational modifications for MAPK1 Gene

  • ISGylated.
  • Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Undergoes regulatory phosphorylation on additional residues such as Ser-246 and Ser-248 in the kinase insert domain (KID) These phosphorylations, which are probably mediated by more than one kinase, are important for binding of MAPK1/ERK2 to importin-7 (IPO7) and its nuclear translocation. In addition, autophosphorylation of Thr-190 was shown to affect the subcellular localization of MAPK1/ERK2 as well. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-187. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. DUSP3 and DUSP6 dephosphorylate specifically MAPK1/ERK2 and MAPK3/ERK1 whereas DUSP9 dephosphorylates a broader range of MAPKs.
  • Ubiquitination at Lys 292
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPK1 Gene

Protein Products

Assay Products

  • Enzo Life Sciences assays for MAPK1
  • Cloud-Clone Corp Assay Kits for MAPK1

Domains & Families for MAPK1 Gene

Graphical View of Domain Structure for InterPro Entry

P28482

UniProtKB/Swiss-Prot:

MK01_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK1: view

Function for MAPK1 Gene

Molecular function for MAPK1 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase 1 (p40,p41),three isoforms,5.5kb highly expressed in forebrain,4.6kb,in skeletal,heart muscle and liver,2.8kb,skeletal,heart muscle,brain,activated and tyrosine phosphorylated in response to insulin NGF and other signals,widely involved in signal transduction,translocated to the nucleus after activation where it phosphorylate nuclear targets
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-185 and Tyr-187 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9. Inactivated by pyrimidylpyrrole inhibitors.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation.
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

Enzyme Numbers (IUBMB) for MAPK1 Gene

Gene Ontology (GO) - Molecular Function for MAPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MAPK1: view

Phenotypes for MAPK1 Gene

MGI mutant phenotypes for MAPK1:
inferred from 12 alleles
GenomeRNAi human phenotypes for MAPK1:
genes like me logo Genes that share phenotypes with MAPK1: view

Human Phenotype Ontology for MAPK1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAPK1 Gene

MGI Knock Outs for MAPK1:

Animal Model Products

miRNA for MAPK1 Gene

miRTarBase miRNAs that target MAPK1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MAPK1 Gene

Localization for MAPK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK1 Gene

Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK1 Gene COMPARTMENTS Subcellular localization image for MAPK1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
extracellular 5
golgi apparatus 5
mitochondrion 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MAPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome TAS 19565474
GO:0005815 microtubule organizing center IEA --
GO:0031143 pseudopodium IEA --
GO:0032839 dendrite cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MAPK1: view

Pathways & Interactions for MAPK1 Gene

SuperPathways for MAPK1 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 MyD88 cascade initiated on plasma membrane
3 IL-2 Pathway
4 Translation Insulin regulation of translation
5 IL-7 Signaling Pathways
genes like me logo Genes that share pathways with MAPK1: view

Pathways by source for MAPK1 Gene

Gene Ontology (GO) - Biological Process for MAPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MAPK1: view

Drugs & Compounds for MAPK1 Gene

(84) Drugs for MAPK1 Gene - From: HMDB, Novoseek, DGIdb, ApexBio, DrugBank, Tocris, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma inhibitor, Target, inducer 115
Isoproterenol Approved Pharma Full agonist, Agonist, Target, inducer 19
Trisenox Approved September 2000 Pharma 0
Sumatriptan Approved, Investigational Pharma Full agonist, Agonist 97
Adenosine triphosphate Approved Nutra 0

(82) Additional Compounds for MAPK1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Pluripotin
839707-37-8
TCS ERK 11e
896720-20-0
TMCB
905105-89-7

(5) Tocris Compounds for MAPK1 Gene

Compound Action Cas Number
FR 180204 Selective ERK inhibitor 865362-74-9
Pluripotin Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal 839707-37-8
TCS ERK 11e Potent and selective ERK2 inhibitor 896720-20-0
TMCB Dual-kinase inhibitor; inhibits CK2 and ERK8 905105-89-7
XMD 8-92 Selective ERK5/BMK1 inhibitor 1234480-50-2

(2) ApexBio Compounds for MAPK1 Gene

Compound Action Cas Number
FR 180204 ERK inhibitor 865362-74-9
Piperine MAPK inhibitor 94-62-2
genes like me logo Genes that share compounds with MAPK1: view

Drug Products

Transcripts for MAPK1 Gene

Unigene Clusters for MAPK1 Gene

Mitogen-activated protein kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK1 Gene

No ASD Table

Relevant External Links for MAPK1 Gene

GeneLoc Exon Structure for
MAPK1
ECgene alternative splicing isoforms for
MAPK1

Expression for MAPK1 Gene

mRNA expression in normal human tissues for MAPK1 Gene

Protein differential expression in normal tissues from HIPED for MAPK1 Gene

This gene is overexpressed in Brain (8.7) and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK1 Gene



SOURCE GeneReport for Unigene cluster for MAPK1 Gene Hs.431850

genes like me logo Genes that share expression patterns with MAPK1: view

Protein tissue co-expression partners for MAPK1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAPK1 Gene

Orthologs for MAPK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPK1 35
  • 92.31 (n)
  • 99.72 (a)
MAPK1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK1 35
  • 94.81 (n)
  • 100 (a)
MAPK1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk1 35
  • 92.62 (n)
  • 99.44 (a)
Mapk1 16
Mapk1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAPK1 35
  • 100 (n)
  • 100 (a)
MAPK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk1 35
  • 91.97 (n)
  • 99.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAPK1 35
  • 86.57 (n)
  • 99.43 (a)
MAPK1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK1 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk1 35
  • 83.81 (n)
  • 97.99 (a)
Str.19446 35
zebrafish
(Danio rerio)
Actinopterygii mapk1 35
  • 79.12 (n)
  • 95.11 (a)
mapk1 36
  • 91 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2326 35
fruit fly
(Drosophila melanogaster)
Insecta CG18732 37
  • 86 (a)
rl 37
  • 81 (a)
rl 35
  • 66.09 (n)
  • 81.98 (a)
rl 36
  • 76 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009207 35
  • 70.32 (n)
  • 86.52 (a)
worm
(Caenorhabditis elegans)
Secernentea C05D10.2a 37
  • 40 (a)
C05D10.2c 37
  • 40 (a)
C49C3.10b 37
  • 29 (a)
F09C12.2 37
  • 40 (a)
mpk-1 37
  • 81 (a)
Y51B9A.9 37
  • 31 (a)
mpk-1 35
  • 68.04 (n)
  • 81.18 (a)
mpk-1 36
  • 63 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL191C 35
  • 56.21 (n)
  • 54.25 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02497g 35
  • 54.84 (n)
  • 54.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KSS1 35
  • 56.86 (n)
  • 53.82 (a)
FUS3 36
  • 49 (a)
ManyToMany
KSS1 36
  • 48 (a)
ManyToMany
FUS3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MPK6 35
  • 56.21 (n)
  • 52.49 (a)
rice
(Oryza sativa)
Liliopsida Os06g0154500 35
  • 57.52 (n)
  • 53.1 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4298 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9711 36
  • 83 (a)
OneToMany
Species with no ortholog for MAPK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK1 Gene

ENSEMBL:
Gene Tree for MAPK1 (if available)
TreeFam:
Gene Tree for MAPK1 (if available)

Paralogs for MAPK1 Gene

Paralogs for MAPK1 Gene

genes like me logo Genes that share paralogs with MAPK1: view

Variants for MAPK1 Gene

Sequence variations from dbSNP and Humsavar for MAPK1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs6928 -- 21,760,715(-) TTTAT(C/G)CGTGT utr-variant-3-prime
rs9340 -- 21,761,064(-) ACATA(C/T)GCACA utr-variant-3-prime
rs12682 -- 21,761,233(-) ACGAG(C/G)GGTTT utr-variant-3-prime
rs13058 -- 21,763,213(-) ATTCT(G/T)TTTCC utr-variant-3-prime
rs13515 -- 21,761,597(-) GACAC(A/G)GAACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAPK1 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv510804 CNV Loss 20534489
dgv4883n71 CNV Loss 21882294
nsv3564 CNV Insertion 18451855
esv2675107 CNV Deletion 23128226
dgv20e196 CNV Duplication 17116639
esv2422374 CNV Duplication 17116639
dgv256n21 CNV Loss 19592680
dgv22e196 CNV Deletion 17116639
nsv527816 CNV Loss 19592680
esv2422338 CNV Deletion 17116639
dgv23e196 CNV Deletion 17116639

Variation tolerance for MAPK1 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK1 Gene

HapMap Linkage Disequilibrium report
MAPK1
Human Gene Mutation Database (HGMD)
MAPK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK1 Gene

Disorders for MAPK1 Gene

MalaCards: The human disease database

(35) MalaCards diseases for MAPK1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chromosome 22q11.2 deletion syndrome, distal
  • chromosome 22q11.2 deletion syndrome distal
pertussis
  • bordetella infection
pancreatic cancer
  • pancreatic carcinoma, somatic
retrograde amnesia
  • amnesia, retrograde
spinal cord injury
  • spinal cord injuries
- elite association - COSMIC cancer census association via MalaCards
Search MAPK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAPK1

Genetic Association Database (GAD)
MAPK1
Human Genome Epidemiology (HuGE) Navigator
MAPK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK1
genes like me logo Genes that share disorders with MAPK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAPK1 Gene

Publications for MAPK1 Gene

  1. IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. (PMID: 12356731) Garcia J. … Porteu F. (EMBO J. 2002) 3 4 23 67
  2. Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1. (PMID: 12529330) He Z. … Dong Z. (J. Biol. Chem. 2003) 23 25 26
  3. Nuclear I^-adrenergic receptors modulate gene expression in adult rat heart. (PMID: 20732414) Vaniotis G. … Allen B.G. (Cell. Signal. 2011) 25 26
  4. Sphingosine kinase 1 regulates mucin production via ERK phosphorylation. (PMID: 19835973) Kono Y. … Nishimura Y. (Pulm Pharmacol Ther 2010) 3 23
  5. Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells. (PMID: 20093341) Han E.H. … Jeong H.G. (Toxicol. Sci. 2010) 3 23

Products for MAPK1 Gene

  • Addgene plasmids for MAPK1

Sources for MAPK1 Gene

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