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Aliases for MAP9 Gene

Aliases for MAP9 Gene

  • Microtubule Associated Protein 9 2 3 5
  • Aster-Associated Protein 2 3 4
  • ASAP 3 4
  • Microtubule-Associated Protein 9 3

External Ids for MAP9 Gene

Previous GeneCards Identifiers for MAP9 Gene

  • GC04M156483
  • GC04M156263
  • GC04M152002

Summaries for MAP9 Gene

Entrez Gene Summary for MAP9 Gene

  • ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MAP9 Gene

MAP9 (Microtubule Associated Protein 9) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MAP9 Gene

  • Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP9 Gene

Genomics for MAP9 Gene

Regulatory Elements for MAP9 Gene

Enhancers for MAP9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G155319 0.5 ENCODE 18.7 +57.2 57182 1.0 JUND POU5F1 CHD7 MAP9 LOC105377502
GH04G155391 0.9 Ensembl ENCODE 4.6 -15.7 -15654 2.0 ZNF639 ZFP37 ZEB2 ZEB1 FOXA1 HIC1 ZFHX2 JUND ZNF366 ZNF629 MAP9 LOC100420289 LOC105377503
GH04G155375 0.9 ENCODE 0.7 +0.2 169 1.8 HDGF SIN3A ZNF2 ETS1 ZNF121 ZNF143 REST ZNF518A ZNF610 SMARCA4 LOC102724776 MAP9 LOC105377502
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP9 on UCSC Golden Path with GeneCards custom track

Promoters for MAP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000175133 270 1400 HDGF ZNF76 SIN3A BMI1 ZNF2 ZBTB40 RFX5 ETS1 ZNF121 ZNF143

Genomic Location for MAP9 Gene

Chromosome:
4
Start:
155,342,658 bp from pter
End:
155,376,970 bp from pter
Size:
34,313 bases
Orientation:
Minus strand

Genomic View for MAP9 Gene

Genes around MAP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP9 Gene

Proteins for MAP9 Gene

  • Protein details for MAP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49MG5-MAP9_HUMAN
    Recommended name:
    Microtubule-associated protein 9
    Protein Accession:
    Q49MG5
    Secondary Accessions:
    • Q4W5I7
    • Q68DU1
    • Q9H781
    • Q9H7B6

    Protein attributes for MAP9 Gene

    Size:
    647 amino acids
    Molecular mass:
    74234 Da
    Quaternary structure:
    • Binds to purified microtubules via its C-terminus.

    Alternative splice isoforms for MAP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP9 Gene

Post-translational modifications for MAP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP9 Gene

Domains & Families for MAP9 Gene

Protein Domains for MAP9 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAP9: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MAP9 Gene

Function for MAP9 Gene

Molecular function for MAP9 Gene

UniProtKB/Swiss-Prot Function:
Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.

Gene Ontology (GO) - Molecular Function for MAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IMP 16049101
genes like me logo Genes that share ontologies with MAP9: view

Phenotypes for MAP9 Gene

genes like me logo Genes that share phenotypes with MAP9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP9 Gene

Localization for MAP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP9 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP9 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000235 astral microtubule IDA 16049101
GO:0005737 cytoplasm IDA,IEA 16049101
GO:0005818 aster IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with MAP9: view

Pathways & Interactions for MAP9 Gene

No Data Available

SIGNOR curated interactions for MAP9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IEA --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007088 regulation of mitotic nuclear division IEA --
GO:0046602 regulation of mitotic centrosome separation IMP 16049101
genes like me logo Genes that share ontologies with MAP9: view

No data available for Pathways by source for MAP9 Gene

Drugs & Compounds for MAP9 Gene

No Compound Related Data Available

Transcripts for MAP9 Gene

Unigene Clusters for MAP9 Gene

Microtubule-associated protein 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3:
SP4: - -
SP5:

Relevant External Links for MAP9 Gene

GeneLoc Exon Structure for
MAP9
ECgene alternative splicing isoforms for
MAP9

Expression for MAP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP9 Gene

Protein differential expression in normal tissues from HIPED for MAP9 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (37.0) and Urine (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP9 Gene



NURSA nuclear receptor signaling pathways regulating expression of MAP9 Gene:

MAP9

SOURCE GeneReport for Unigene cluster for MAP9 Gene:

Hs.61271

Evidence on tissue expression from TISSUES for MAP9 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MAP9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP9 Gene

Orthologs for MAP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP9 34 35
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 91 (a)
OneToMany
MAP9 34
  • 87.01 (n)
-- 35
  • 81 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MAP9 34 35
  • 86.12 (n)
rat
(Rattus norvegicus)
Mammalia Map9 34
  • 77.17 (n)
mouse
(Mus musculus)
Mammalia Map9 34 16 35
  • 76.96 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP9 35
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP9 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP9 35
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP9 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map9 34
  • 54.79 (n)
zebrafish
(Danio rerio)
Actinopterygii map9 35
  • 27 (a)
OneToOne
Species where no ortholog for MAP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP9 Gene

ENSEMBL:
Gene Tree for MAP9 (if available)
TreeFam:
Gene Tree for MAP9 (if available)

Paralogs for MAP9 Gene

No data available for Paralogs for MAP9 Gene

Variants for MAP9 Gene

Sequence variations from dbSNP and Humsavar for MAP9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000069207 -- 155,357,827(+) CCTGA(C/G)GGGCT intron-variant
rs10001550 -- 155,352,284(+) CTTTC(A/T)ATGTT intron-variant, upstream-variant-2KB
rs1000162264 -- 155,366,235(+) GTGCC(C/T)GTAGT intron-variant
rs1000209259 -- 155,371,091(+) AAACA(C/T)ATCCT intron-variant
rs1000213002 -- 155,370,506(+) CCCTC(C/T)TGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP9 Gene

Variant ID Type Subtype PubMed ID
esv2619911 CNV insertion 19546169
nsv1114586 CNV deletion 24896259
nsv512839 CNV insertion 21212237
nsv819084 CNV loss 19587683
nsv819615 CNV loss 19587683

Variation tolerance for MAP9 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.39; 97.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP9 Gene

Disorders for MAP9 Gene

Relevant External Links for MAP9

Genetic Association Database (GAD)
MAP9
Human Genome Epidemiology (HuGE) Navigator
MAP9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP9

No disorders were found for MAP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP9 Gene

Publications for MAP9 Gene

  1. ASAP, a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis. (PMID: 16049101) Saffin J.-M. … Rouquier S. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for MAP9 Gene

Sources for MAP9 Gene

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