MAP9 Gene
protein-coding GIFtS: 45
GCID: GC04M156263
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|
microtubule-associated protein 9
| |
Aliases
for MAP9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Microtubule-Associated Protein 91 2 | | ASAP1 2 3 5 | | Aster-Associated Protein2 3 | | FLJ211591 |
Export aliases for MAP9 gene to outside databasesPrevious GC identifers: GC04M156483 GC04M152002 |
Summaries
for MAP9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAP9:
ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin etal., 2005 (PubMed 16049101)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: MAP9_HUMAN, Q49MG5Function: Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosisprogression and cytokinesis. May act by stabilizing interphase microtubules
|
Genomic Views
for MAP9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP9 gene promoter:
RFX1 MyoD POU3F2 (N-Oct-5b) STAT5A HNF-3beta CREB MZF-1 Pax-4a En-1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q32.1 Ensembl cytogenetic band: 4q32.1 HGNC cytogenetic band: 4q32.1MAP9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M156263: view genomic region
(about GC identifiers)
Start:
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156,263,810 bp from pter |
End:
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156,298,122 bp from pter |
Size:
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34,313 bases |
Orientation:
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minus strand |
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Proteins
for MAP9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAP9_HUMAN, Q49MG5 (See
protein sequence)Recommended Name: Microtubule-associated protein 9 Size: 647 amino acids; 74234 Da
Subunit: Binds to purified microtubules via its C-terminus
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Localizes tomicrotubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body duringcytokinesis
Developmental stage: Constitutively expressed during the cell cycle
Secondary accessions: Q4W5I7 Q68DU1 Q9H781 Q9H7B6Alternative splicing: 2 isoforms: Q49MG5-1 Q49MG5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MAP9: NX_Q49MG5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q49MG5
MAP9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001034669.1
ENSEMBL proteins: ENSP00000310593 ENSP00000427402 ENSP00000422989 ENSP00000413553 ENSP00000394048 ENSP00000368550 ENSP00000401509
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
MAP9 for ontologies About GeneDecksing
MAP9 Antibody Products:
Assay Products for MAP9: |
Protein
Domains /
Families
for MAP9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP9 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q49MG5ProtoNet protein and cluster: Q49MG5 |
Function
for MAP9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAP9_HUMAN, Q49MG5Function: Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosisprogression and cytokinesis. May act by stabilizing interphase microtubules
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP9 |
|
Pathways & Interactions
for MAP9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAP9
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for MAP9 (ENSP000003105934) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
MAP9 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAP9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAP9
Search CenterWatch for drugs/clinical trials and news about MAP9
|
Transcripts
for MAP9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAP9 gene: NM_001039580.1 Unigene Cluster for MAP9: Microtubule-associated protein 9 Hs.61271 [show with all ESTs]Unigene Representative Sequence: NM_0010395808 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000311277(uc003ios.3 uc011cin.2 uc010iqa.1 uc003iot.1)
ENST00000515654 ENST00000503466 ENST00000424373 ENST00000433024 ENST00000379248(uc010iqb.2)
ENST00000481250 ENST00000450097
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAP9 (NM_001039580) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP9 |
Additional cDNA sequence: AK024730.1 AK024812.1 AK301075.1 AY690636.1 BC022852.1 BC056683.1 BC128540.1 BC128541.1 BC146864.1 CR749274.1 5 DOTS entries: DT.97837203 DT.101965274 DT.97837204 DT.99990116 DT.97776186 24/92 AceView cDNA sequences (see all 92): AI656815 AI498318 BU633891 BU629726 AI433877 H97366 AI079258 AA805679 AI075224 AI080389 CR749274 N27433 AA025538 AA843565 BU928828 AI887898 BX112660 H97802 N34719 AA912258 AA845360 AI034154 R96089 AL700725
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MAP9 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAP9
|
Expression
for MAP9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAP9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATGCACAG
About this image
See MAP9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP9
SOURCE GeneReport for Unigene cluster: Hs.61271
SABiosciences Custom PCR Arrays for MAP9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP9 |
Orthologs
for MAP9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAP9 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for MAP9 (if available)
TreeFam Gene Tree for MAP9 (if available) |
Paralogs
for MAP9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAP9 gene
- CCDC342
MAP9 for paralogs About GeneDecksing
|
Genomic Variants
for MAP9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MAP9
3 Indels: 98928 59177 59176 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP9 |
|
Disorders
/ Diseases
for MAP9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAP9 for disorders About GeneDecksing
OMIM gene information: 610070
OMIM disorders: --
3  diseases for MAP9: About MalaCardsmetachromatic leukodystrophy hemopericardium leukodystrophy
1 disease from the University of Copenhagen DISEASES database for MAP9:Metachromatic leukodystrophy Human Genome Epidemiology (HuGE) Navigator: MAP9 (1 document)
Export disorders for MAP9 gene to outside databases
|
Publications
for MAP9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAP9 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with MAP9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ASAP, a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis. (PubMed id 16049101)1, 2, 3 Saffin J.-M.... Rouquier S. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Induction of ASAP (MAP9) contributes to p53 stabilizat ion in response to DNA damage. (PubMed id 22672907)1 Basbous J....Rouquier S. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Plk1 regulates both ASAP localization and its role in spindle pole integrity. (PubMed id 20615875)1 Eot-Houllier G....Rouquier S. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis. (PubMed id 17925329)1 Venoux M....Rouquier S. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for MAP9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAP9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAP9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAP9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAP9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MAP9 gene:
Search GeneIP for patents involving MAP9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAP9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MAP9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP9 | | | OriGene Protein Over-expression Lysate for MAP9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAP9 | | OriGene 3'-UTR Clone for MAP9 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP9 |
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 | | | MAP9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP9 |
|  |  |  | | | | ThermoFisher Antibodies for MAP9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP9 |
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