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Aliases for MAP9 Gene

Aliases for MAP9 Gene

  • Microtubule-Associated Protein 9 2 3
  • Aster-Associated Protein 2 3 4
  • ASAP 3 4 6

External Ids for MAP9 Gene

Summaries for MAP9 Gene

Entrez Gene Summary for MAP9 Gene

  • ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MAP9 Gene

MAP9 (Microtubule-Associated Protein 9) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MAP9 Gene

  • Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP9 Gene

Genomics for MAP9 Gene

Genomic Location for MAP9 Gene

Start:
155,342,658 bp from pter
End:
155,376,970 bp from pter
Size:
34,313 bases
Orientation:
Minus strand

Genomic View for MAP9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP9 Gene

Regulatory Elements for MAP9 Gene

Proteins for MAP9 Gene

  • Protein details for MAP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49MG5-MAP9_HUMAN
    Recommended name:
    Microtubule-associated protein 9
    Protein Accession:
    Q49MG5
    Secondary Accessions:
    • Q4W5I7
    • Q68DU1
    • Q9H781
    • Q9H7B6

    Protein attributes for MAP9 Gene

    Size:
    647 amino acids
    Molecular mass:
    74234 Da
    Quaternary structure:
    • Binds to purified microtubules via its C-terminus

    Alternative splice isoforms for MAP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP9 Gene

Proteomics data for MAP9 Gene at MOPED

Post-translational modifications for MAP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP9 Gene

No data available for DME Specific Peptides for MAP9 Gene

Domains for MAP9 Gene

Protein Domains for MAP9 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with MAP9: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MAP9 Gene

Function for MAP9 Gene

Molecular function for MAP9 Gene

UniProtKB/Swiss-Prot Function: Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAP9 Gene

Localization for MAP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP9 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, localizes to the central body during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP9 Gene COMPARTMENTS Subcellular localization image for MAP9 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 4
nucleus 4
cytosol 3
chloroplast 1

Gene Ontology (GO) - Cellular Components for MAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000235 astral microtubule IEA --
GO:0005818 aster --
GO:0015630 microtubule cytoskeleton --
GO:0072686 mitotic spindle --
GO:1990023 mitotic spindle midzone IEA --
genes like me logo Genes that share ontologies with MAP9: view

Pathways for MAP9 Gene

SuperPathways for MAP9 Gene

No Data Available

Interacting Proteins for MAP9 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000310593%0d%0a9606.ENSP00000380921%0d%0a9606.ENSP00000269305%0d%0a9606.ENSP00000263253%0d%0a9606.ENSP00000463999%0d%0a
Selected Interacting proteins: ENSP00000310593 for MAP9 Gene via STRING

Gene Ontology (GO) - Biological Process for MAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IEA --
GO:0007088 regulation of mitotic nuclear division IEA --
GO:0051225 spindle assembly --
GO:0090307 mitotic spindle assembly IEA --
genes like me logo Genes that share ontologies with MAP9: view

No data available for Pathways by source for MAP9 Gene

Transcripts for MAP9 Gene

Unigene Clusters for MAP9 Gene

Microtubule-associated protein 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3:
SP4: - -
SP5:

Relevant External Links for MAP9 Gene

GeneLoc Exon Structure for
MAP9
ECgene alternative splicing isoforms for
MAP9

Expression for MAP9 Gene

mRNA expression in normal human tissues for MAP9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MAP9 Gene

SOURCE GeneReport for Unigene cluster for MAP9 Gene Hs.61271

genes like me logo Genes that share expressions with MAP9: view

Orthologs for MAP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP9 36
  • 99.48 (n)
  • 98.92 (a)
MAP9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP9 36
  • 86.12 (n)
  • 78.63 (a)
MAP9 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 81 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
MAP9 36
  • 87.01 (n)
  • 81.52 (a)
mouse
(Mus musculus)
Mammalia Map9 36
  • 76.96 (n)
  • 71.29 (a)
Map9 16
Map9 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP9 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP9 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map9 36
  • 77.17 (n)
  • 71.29 (a)
chicken
(Gallus gallus)
Aves MAP9 37
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP9 37
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map9 36
  • 54.79 (n)
  • 40.97 (a)
zebrafish
(Danio rerio)
Actinopterygii map9 37
  • 27 (a)
OneToOne
Species with no ortholog for MAP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP9 Gene

ENSEMBL:
Gene Tree for MAP9 (if available)
TreeFam:
Gene Tree for MAP9 (if available)

Paralogs for MAP9 Gene

No data available for Paralogs for MAP9 Gene

Variants for MAP9 Gene

Sequence variations from dbSNP and Humsavar for MAP9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs10326 -- 155,342,719(-) TGTCA(C/T)GGGTC utr-variant-3-prime
rs719688 -- 155,370,308(+) atcac(A/T)ccttt intron-variant
rs985468 -- 155,372,306(+) GATGA(C/T)ATGCA intron-variant
rs986416 -- 155,375,716(-) TTGAA(A/T)TTGGT intron-variant
rs995595 -- 155,378,729(+) ACATC(C/T)AGACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAP9 Gene

Variant ID Type Subtype PubMed ID
nsv881641 CNV Loss 21882294
esv2619911 CNV Insertion 19546169
nsv512839 CNV Insertion 21212237
nsv819615 CNV Loss 19587683
nsv819084 CNV Loss 19587683
nsv881593 CNV Loss 21882294

Relevant External Links for MAP9 Gene

HapMap Linkage Disequilibrium report
MAP9

Disorders for MAP9 Gene

(1) University of Copenhagen DISEASES for MAP9 Gene

Relevant External Links for MAP9

Genetic Association Database (GAD)
MAP9
Human Genome Epidemiology (HuGE) Navigator
MAP9
genes like me logo Genes that share disorders with MAP9: view

No data available for UniProtKB/Swiss-Prot for MAP9 Gene

Publications for MAP9 Gene

  1. ASAP, a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis. (PMID: 16049101) Saffin J.-M. … Rouquier S. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Plk1 regulates both ASAP localization and its role in spindle pole integrity. (PMID: 20615875) Eot-Houllier G. … Rouquier S. (J. Biol. Chem. 2010) 3

Products for MAP9 Gene

Sources for MAP9 Gene

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