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Aliases for MAP7D3 Gene

Aliases for MAP7D3 Gene

  • MAP7 Domain Containing 3 2 3 5
  • MDP3 3 4
  • MAP7 Domain-Containing Protein 3 3

External Ids for MAP7D3 Gene

Previous GeneCards Identifiers for MAP7D3 Gene

  • GC0XM135124
  • GC0XM135295
  • GC0XM124567

Summaries for MAP7D3 Gene

Entrez Gene Summary for MAP7D3 Gene

  • The protein encoded by this gene belongs to the MAP7 (microtubule-associated protein 7) family. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Mar 2010]

GeneCards Summary for MAP7D3 Gene

MAP7D3 (MAP7 Domain Containing 3) is a Protein Coding gene. Diseases associated with MAP7D3 include Scapuloperoneal Myopathy. GO annotations related to this gene include structural molecule activity and tubulin binding. An important paralog of this gene is MAP7.

UniProtKB/Swiss-Prot for MAP7D3 Gene

  • Promotes the assembly and stability of microtubules.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP7D3 Gene

Genomics for MAP7D3 Gene

Regulatory Elements for MAP7D3 Gene

Enhancers for MAP7D3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG136166 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +87.6 87592 5.8 PKNOX1 FEZF1 ZNF2 GATA2 FOS ZNF263 SP3 TSHZ1 REST ZNF623 FHL1 MAP7D3 PIR45658
GH0XG136213 1.2 Ensembl ENCODE dbSUPER 23.3 +41.6 41632 3.0 CTCF RAD21 ZNF664 HIC1 POLR2A ZNF600 FOS MAFK BHLHE40 ATF2 MAP7D3 FHL1 PIR34436 GC0XM136223
GH0XG136209 1.1 Ensembl ENCODE dbSUPER 22.6 +46.9 46949 1.0 CTCF ZNF654 SMC3 CREB1 ZNF600 REST PRDM4 RAD21 MAP7D3 PIR34436 PIR45658
GH0XG136210 1 Ensembl ENCODE dbSUPER 21.4 +45.9 45856 0.9 ZFP69B ZNF692 GLIS1 MAP7D3 SLC9A6 PIR34436 PIR45658
GH0XG136192 1.2 FANTOM5 Ensembl ENCODE dbSUPER 15.7 +63.3 63287 1.9 HNF4A NFE2 CT45A6 MAP7D3 FHL1 MMGT1 PIR45658
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP7D3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP7D3 Gene

Chromosome:
X
Start:
136,213,220 bp from pter
End:
136,256,482 bp from pter
Size:
43,263 bases
Orientation:
Minus strand

Genomic View for MAP7D3 Gene

Genes around MAP7D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP7D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP7D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP7D3 Gene

Proteins for MAP7D3 Gene

  • Protein details for MAP7D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWC1-MA7D3_HUMAN
    Recommended name:
    MAP7 domain-containing protein 3
    Protein Accession:
    Q8IWC1
    Secondary Accessions:
    • A2A2J0
    • A6NCZ7
    • A6NHR4
    • B4DWD2
    • H7BY77
    • Q5JXI5
    • Q5JXI6
    • Q6P2S1
    • Q9H9M8

    Protein attributes for MAP7D3 Gene

    Size:
    876 amino acids
    Molecular mass:
    98429 Da
    Quaternary structure:
    • Interacts (via N-terminus coiled coil domains) with tubulin and microtubules.
    SequenceCaution:
    • Sequence=AAH64350.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAM21578.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP7D3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP7D3 Gene

Post-translational modifications for MAP7D3 Gene

  • Ubiquitination at Lys541
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP7D3 Gene

No data available for DME Specific Peptides for MAP7D3 Gene

Domains & Families for MAP7D3 Gene

Protein Domains for MAP7D3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP7D3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWC1

UniProtKB/Swiss-Prot:

MA7D3_HUMAN :
  • Belongs to the MAP7 family.
Family:
  • Belongs to the MAP7 family.
genes like me logo Genes that share domains with MAP7D3: view

No data available for Gene Families for MAP7D3 Gene

Function for MAP7D3 Gene

Molecular function for MAP7D3 Gene

UniProtKB/Swiss-Prot Function:
Promotes the assembly and stability of microtubules.
UniProtKB/Swiss-Prot Induction:
Expression is cell cycle dependent with the highest levels during G1, S, and M phases, and low level in G2 phase.

Gene Ontology (GO) - Molecular Function for MAP7D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
GO:0008017 microtubule binding IDA 22142902
GO:0015631 tubulin binding IDA 22142902
genes like me logo Genes that share ontologies with MAP7D3: view
genes like me logo Genes that share phenotypes with MAP7D3: view

Animal Model Products

CRISPR Products

miRNA for MAP7D3 Gene

miRTarBase miRNAs that target MAP7D3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP7D3 Gene

Localization for MAP7D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP7D3 Gene

Cytoplasm, cytoskeleton, spindle. Note=Localizes to the microtubules throughout mitosis. {ECO:0000269 PubMed:22142902}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP7D3 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for MAP7D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
GO:0015630 microtubule cytoskeleton IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MAP7D3: view

Pathways & Interactions for MAP7D3 Gene

SuperPathways for MAP7D3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP7D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IDA 22142902
GO:0046785 microtubule polymerization IDA 24927501
genes like me logo Genes that share ontologies with MAP7D3: view

No data available for Pathways by source and SIGNOR curated interactions for MAP7D3 Gene

Drugs & Compounds for MAP7D3 Gene

No Compound Related Data Available

Transcripts for MAP7D3 Gene

mRNA/cDNA for MAP7D3 Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP7D3 Gene

MAP7 domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP7D3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: -
SP2: - -
SP3:

Relevant External Links for MAP7D3 Gene

GeneLoc Exon Structure for
MAP7D3
ECgene alternative splicing isoforms for
MAP7D3

Expression for MAP7D3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP7D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP7D3 Gene

This gene is overexpressed in Artery - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for MAP7D3 Gene

This gene is overexpressed in Bone marrow stromal cell (19.5), Adipocyte (17.2), and Testis (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP7D3 Gene



NURSA nuclear receptor signaling pathways regulating expression of MAP7D3 Gene:

MAP7D3

SOURCE GeneReport for Unigene cluster for MAP7D3 Gene:

Hs.446275

Evidence on tissue expression from TISSUES for MAP7D3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MAP7D3: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP7D3 Gene

Orthologs for MAP7D3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP7D3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP7D3 34
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia MAP7D3 34 35
  • 71.31 (n)
cow
(Bos Taurus)
Mammalia MAP7D3 34 35
  • 67.43 (n)
rat
(Rattus norvegicus)
Mammalia Map7d3 34
  • 59.65 (n)
mouse
(Mus musculus)
Mammalia Mtap7d3 34 35
  • 58.34 (n)
Map7d3 16
platypus
(Ornithorhynchus anatinus)
Mammalia MAP7D3 35
  • 29 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP7D3 35
  • 25 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP7D3 35
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP7D3 35
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii map7d3 35
  • 25 (a)
OneToOne
Species where no ortholog for MAP7D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP7D3 Gene

ENSEMBL:
Gene Tree for MAP7D3 (if available)
TreeFam:
Gene Tree for MAP7D3 (if available)

Paralogs for MAP7D3 Gene

Paralogs for MAP7D3 Gene

genes like me logo Genes that share paralogs with MAP7D3: view

Variants for MAP7D3 Gene

Sequence variations from dbSNP and Humsavar for MAP7D3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000053954 -- 136,222,648(+) ATCTA(C/T)GGGGG intron-variant
rs1000086069 -- 136,236,799(+) ATTTG(C/T)TCTTA intron-variant
rs1000157967 -- 136,221,616(+) CACTG(C/T)CCTGC intron-variant
rs1000224291 -- 136,249,801(+) CATGC(A/G)ATATT intron-variant
rs1000276577 -- 136,248,171(+) AGCCT(A/G)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP7D3 Gene

Variant ID Type Subtype PubMed ID
esv2668671 CNV deletion 23128226
esv3559371 CNV deletion 23714750
esv3574718 CNV loss 25503493
nsv1115293 CNV deletion 24896259

Variation tolerance for MAP7D3 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP7D3 Gene

Human Gene Mutation Database (HGMD)
MAP7D3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP7D3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP7D3 Gene

Disorders for MAP7D3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP7D3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
scapuloperoneal myopathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAP7D3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP7D3
genes like me logo Genes that share disorders with MAP7D3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP7D3 Gene

Publications for MAP7D3 Gene

  1. C-terminal region of MAP7 domain containing protein 3 (MAP7D3) promotes microtubule polymerization by binding at the C-terminal tail of tubulin. (PMID: 24927501) Yadav S. … Panda D. (PLoS ONE 2014) 2 3 4 64
  2. Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability. (PMID: 22142902) Sun X. … Zhou J. (Cell Cycle 2011) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for MAP7D3 Gene

Sources for MAP7D3 Gene

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