MAP7D3 Gene
protein-coding GIFtS: 41
GCID: GC0XM135295
|
|
MAP7 domain containing 3
| |
Aliases
for MAP7D3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MAP7 Domain Containing 31 2 | | FLJ126491 | | MAP7 Domain-Containing Protein 32 |
Export aliases for MAP7D3 gene to outside databasesPrevious GC identifers: GC0XM135124 GC0XM124567 |
Summaries
for MAP7D3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAP7D3:
The protein encoded by this gene belongs to the MAP7 (microtubule-associated protein 7) family. Alternatively splicedtranscript variants encoding different isoforms have been found. (provided by RefSeq, Mar 2010)
|
Genomic Views
for MAP7D3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP7D3 gene promoter:
C/EBPbeta SREBP-1c HNF-3beta Evi-1 C/EBPalpha SREBP-1b E2F-1 E2F SREBP-1a HFH-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP7D3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP7D3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26.3MAP7D3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM135295: view genomic region
(about GC identifiers)
Start:
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135,295,379 bp from pter |
End:
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135,338,641 bp from pter |
Size:
|
43,263 bases |
Orientation:
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minus strand |
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Proteins
for MAP7D3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MA7D3_HUMAN, Q8IWC1 (See
protein sequence)Recommended Name: MAP7 domain-containing protein 3 Size: 876 amino acids; 98429 Da
Subcellular location: Cytoplasm, cytoskeleton, spindle. Note=Localizes to the microtubules throughout mitosis
Sequence caution: Sequence=AAH64350.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=CAM21578.1; Type=Erroneous gene model prediction;
Secondary accessions: A2A2J0 A6NCZ7 A6NHR4 B4DWD2 H7BY77 Q5JXI5 Q5JXI6 Q6P2S1 Q9H9M8Alternative splicing: 4 isoforms: Q8IWC1-1 Q8IWC1-2 Q8IWC1-3 Q8IWC1-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MAP7D3: NX_Q8IWC1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWC1
MAP7D3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001166987.1 NP_001166988.1 NP_078873.2
ENSEMBL proteins: ENSP00000359695 ENSP00000318086 ENSP00000359694 ENSP00000359697
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
MAP7D3 for ontologies About GeneDecksing
MAP7D3 Antibody Products:
Assay Products for MAP7D3: |
Protein
Domains /
Families
for MAP7D3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP7D3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IWC1ProtoNet protein and cluster: Q8IWC1 UniProtKB/Swiss-Prot: MA7D3_HUMAN, Q8IWC1Similarity: Belongs to the MAP7 family |
Function
for MAP7D3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP7D3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP7D3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): MAP7D3 (NM_024597) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP7D3 |
2 GenomeRNAi human phenotypes for MAP7D3:
|
Pathways & Interactions
for MAP7D3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAP7D3
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for MAP7D3 (Q8IWC13 ENSP000003180864) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for MAP7D3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAP7D3
Search CenterWatch for drugs/clinical trials and news about MAP7D3 / MA7D3
|
Transcripts
for MAP7D3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAP7D3 gene (4 alternative transcripts): NM_001173516.1 NM_001173517.1 NM_024597.3 NM_024765.1 Unigene Cluster for MAP7D3: MAP7 domain containing 3 Hs.446275 [show with all ESTs]Unigene Representative Sequence: NM_0011735178 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370661(uc004ezs.3) ENST00000316077(uc004ezt.3 uc010nsa.2)
ENST00000471510 ENST00000370660 ENST00000489788 ENST00000495432 ENST00000477124
ENST00000370663(uc011mwc.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP7D3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP7D3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MAP7D3 (NM_024597) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP7D3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAP7D3 |
Additional cDNA sequence: AK022711.1 AK301478.1 AL832120.1 AL832475.1 BC040518.1 BC064350.1 10 DOTS entries: DT.97833409 DT.121291084 DT.100782237 DT.442292 DT.99933418 DT.101981099 DT.95155901 DT.40262827 DT.40229253 DT.100738370 24/100 AceView cDNA sequences (see all 100): BM834988 AI699424 BF108839 AI279408 BQ218597 AW444883 AI380710 BE856148 AL702769 BE856122 AA385805 AA815048 AI246356 CB124338 BM978757 AW206053 BE221977 AI659784 AA972012 AU125700 BC064350 AI653093 CB126939 AI797185
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MAP7D3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAP7D3
|
Expression
for MAP7D3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAP7D3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACATCTTGCC
About this image
See MAP7D3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP7D3
SOURCE GeneReport for Unigene cluster: Hs.446275
SABiosciences Custom PCR Arrays for MAP7D3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP7D3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP7D3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP7D3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP7D3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP7D3 |
Orthologs
for MAP7D3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAP7D3 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MAP7D36 |
Uncharacterized protein |
28(a) |
1 ↔ 1 |
4(4246166-4278626) |
lizard
(Anolis carolinensis) |
Reptilia |
MAP7D36 |
-- |
28(a) |
1 ↔ 1 |
GL343562.1(24172-49388) |
zebrafish
(Danio rerio) |
Actinopterygii |
BX511227.16 |
-- |
18(a) |
1 ↔ 1 |
14(32538392-32585268) |
fruit fly
(Drosophila melanogaster) |
Insecta |
ens6 |
ensconsin |
8(a) |
1 → many |
3L(4123138-4134550) |
ENSEMBL Gene Tree for MAP7D3 (if available)
TreeFam Gene Tree for MAP7D3 (if available) |
Paralogs
for MAP7D3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAP7D3 gene
- MAP7D22 INCENP2 MAP7D12 MAP72
MAP7D3 for paralogs About GeneDecksing
|
Genomic Variants
for MAP7D3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAP7D3 (135295379 - 135338641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAP7D3: --
Human Gene Mutation Database (HGMD): MAP7D3
Locus Specific Mutation Databases (LSDB): MAP7D3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP7D3 |
|
Disorders
/ Diseases
for MAP7D3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MAP7D3 for disorders About MalaCards
MAP7D3 for disorders About GeneDecksing
Export disorders for MAP7D3 gene to outside databases
|
Publications
for MAP7D3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAP7D3 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with MAP7D3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mdp3 is a novel microtubule-binding protein that regul ates microtubule assembly and stability. (PubMed id 22142902)1 Sun X....Zhou J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for MAP7D3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAP7D3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAP7D3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAP7D3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAP7D3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MAP7D3 gene:
Search GeneIP for patents involving MAP7D3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAP7D3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MAP7D3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP7D3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP7D3 | | | OriGene Protein Over-expression Lysate for MAP7D3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAP7D3 | | OriGene 3'-UTR Clone for MAP7D3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP7D3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP7D3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP7D3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP7D3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP7D3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP7D3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP7D3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP7D3 |
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| |  |  |  |  | | | | |
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 | | | MAP7D3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP7D3 |
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