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Aliases for MAP7D3 Gene

Aliases for MAP7D3 Gene

  • MAP7 Domain Containing 3 2 3 5
  • MDP3 3 4

External Ids for MAP7D3 Gene

Previous GeneCards Identifiers for MAP7D3 Gene

  • GC0XM135124
  • GC0XM135295
  • GC0XM124567

Summaries for MAP7D3 Gene

Entrez Gene Summary for MAP7D3 Gene

  • The protein encoded by this gene belongs to the MAP7 (microtubule-associated protein 7) family. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Mar 2010]

GeneCards Summary for MAP7D3 Gene

MAP7D3 (MAP7 Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity and tubulin binding. An important paralog of this gene is MAP7D1.

UniProtKB/Swiss-Prot for MAP7D3 Gene

  • Promotes the assembly and stability of microtubules.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP7D3 Gene

Genomics for MAP7D3 Gene

Regulatory Elements for MAP7D3 Gene

Enhancers for MAP7D3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAP7D3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP7D3 Gene

136,213,220 bp from pter
136,256,482 bp from pter
43,263 bases
Minus strand

Genomic View for MAP7D3 Gene

Genes around MAP7D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP7D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP7D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP7D3 Gene

Proteins for MAP7D3 Gene

  • Protein details for MAP7D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAP7 domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A2A2J0
    • A6NCZ7
    • A6NHR4
    • B4DWD2
    • H7BY77
    • Q5JXI5
    • Q5JXI6
    • Q6P2S1
    • Q9H9M8

    Protein attributes for MAP7D3 Gene

    876 amino acids
    Molecular mass:
    98429 Da
    Quaternary structure:
    • Interacts (via N-terminus coiled coil domains) with tubulin and microtubules.
    • Sequence=AAH64350.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAM21578.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP7D3 Gene


neXtProt entry for MAP7D3 Gene

Proteomics data for MAP7D3 Gene at MOPED

Post-translational modifications for MAP7D3 Gene

  • Ubiquitination at Lys 541
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP7D3 Gene

No data available for DME Specific Peptides for MAP7D3 Gene

Domains & Families for MAP7D3 Gene

Protein Domains for MAP7D3 Gene


Suggested Antigen Peptide Sequences for MAP7D3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MAP7 family.
  • Belongs to the MAP7 family.
genes like me logo Genes that share domains with MAP7D3: view

No data available for Gene Families for MAP7D3 Gene

Function for MAP7D3 Gene

Molecular function for MAP7D3 Gene

UniProtKB/Swiss-Prot Function:
Promotes the assembly and stability of microtubules.
UniProtKB/Swiss-Prot Induction:
Expression is cell cycle dependent with the highest levels during G1, S, and M phases, and low level in G2 phase.
genes like me logo Genes that share phenotypes with MAP7D3: view

Animal Model Products

CRISPR Products

miRNA for MAP7D3 Gene

miRTarBase miRNAs that target MAP7D3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP7D3 Gene

Localization for MAP7D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP7D3 Gene

Cytoplasm, cytoskeleton, spindle. Note=Localizes to the microtubules throughout mitosis. {ECO:0000269 PubMed:22142902}.

Subcellular locations from

Jensen Localization Image for MAP7D3 Gene COMPARTMENTS Subcellular localization image for MAP7D3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MAP7D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005819 spindle IEA --
GO:0015629 actin cytoskeleton IDA --
GO:0015630 microtubule cytoskeleton IEA,IBA --
genes like me logo Genes that share ontologies with MAP7D3: view

Pathways & Interactions for MAP7D3 Gene

SuperPathways for MAP7D3 Gene

No Data Available

Interacting Proteins for MAP7D3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000318086 Q8IWC1-MA7D3_HUMAN for MAP7D3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MAP7D3 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAP7D3 Gene

Drugs & Compounds for MAP7D3 Gene

No Compound Related Data Available

Transcripts for MAP7D3 Gene

Unigene Clusters for MAP7D3 Gene

MAP7 domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP7D3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: -
SP2: - -

Relevant External Links for MAP7D3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP7D3 Gene

mRNA expression in normal human tissues for MAP7D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP7D3 Gene

This gene is overexpressed in Artery - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for MAP7D3 Gene

This gene is overexpressed in Bone marrow stromal cell (19.5), Adipocyte (17.2), and Testis (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP7D3 Gene

SOURCE GeneReport for Unigene cluster for MAP7D3 Gene Hs.446275

genes like me logo Genes that share expression patterns with MAP7D3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MAP7D3 Gene

Orthologs for MAP7D3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP7D3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAP7D3 35
  • 67.43 (n)
  • 52.39 (a)
MAP7D3 36
  • 53 (a)
(Canis familiaris)
Mammalia MAP7D3 35
  • 71.31 (n)
  • 60.29 (a)
MAP7D3 36
  • 57 (a)
(Mus musculus)
Mammalia Mtap7d3 35
  • 58.34 (n)
  • 41.09 (a)
Mtap7d3 16
Mtap7d3 36
  • 30 (a)
(Pan troglodytes)
Mammalia MAP7D3 35
  • 99.14 (n)
  • 98.32 (a)
(Rattus norvegicus)
Mammalia Map7d3 35
  • 59.65 (n)
  • 44.21 (a)
(Monodelphis domestica)
Mammalia MAP7D3 36
  • 25 (a)
(Ornithorhynchus anatinus)
Mammalia MAP7D3 36
  • 29 (a)
(Gallus gallus)
Aves MAP7D3 36
  • 31 (a)
(Anolis carolinensis)
Reptilia MAP7D3 36
  • 33 (a)
(Danio rerio)
Actinopterygii map7d3 36
  • 25 (a)
Species with no ortholog for MAP7D3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP7D3 Gene

Gene Tree for MAP7D3 (if available)
Gene Tree for MAP7D3 (if available)

Paralogs for MAP7D3 Gene

Paralogs for MAP7D3 Gene

genes like me logo Genes that share paralogs with MAP7D3: view

Variants for MAP7D3 Gene

Sequence variations from dbSNP and Humsavar for MAP7D3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1055497 - 136,230,875(+) CATTT(G/T)CAGGA reference, missense
rs2273221 - 136,228,626(+) ACCTT(C/T)GCTGC reference, missense
rs747701786 -- 136,231,770(+) GACTC(A/G)CTTCC reference, missense
rs747728270 -- 136,216,468(+) ATGGT(A/G)CCATG intron-variant, downstream-variant-500B
rs747775938 -- 136,235,673(+) GAACC(C/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP7D3 Gene

Variant ID Type Subtype PubMed ID
esv2668671 CNV Deletion 23128226

Variation tolerance for MAP7D3 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP7D3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP7D3 Gene

Disorders for MAP7D3 Gene

Relevant External Links for MAP7D3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAP7D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP7D3 Gene

Publications for MAP7D3 Gene

  1. C-terminal region of MAP7 domain containing protein 3 (MAP7D3) promotes microtubule polymerization by binding at the C-terminal tail of tubulin. (PMID: 24927501) Yadav S. … Panda D. (PLoS ONE 2014) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for MAP7D3 Gene

Sources for MAP7D3 Gene