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Aliases for MAP7D2 Gene

Aliases for MAP7D2 Gene

  • MAP7 Domain Containing 2 2 3 5

External Ids for MAP7D2 Gene

Previous GeneCards Identifiers for MAP7D2 Gene

  • GC0XM019935
  • GC0XM017770

Summaries for MAP7D2 Gene

GeneCards Summary for MAP7D2 Gene

MAP7D2 (MAP7 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is MAP7.

Additional gene information for MAP7D2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP7D2 Gene

Genomics for MAP7D2 Gene

Regulatory Elements for MAP7D2 Gene

Enhancers for MAP7D2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH020066 1.1 Ensembl ENCODE 12.8 +49.3 49254 1 ZBTB40 RAD21 ZNF143 FOS ZNF654 CEBPB ZEB2 REST MAFF PRDM4 BCLAF3 MAP7D2 SH3KBP1 MIR23C
GH0XH019989 1.1 Ensembl ENCODE 12.4 +126.3 126296 2 RB1 ZNF76 SIN3A RAD21 GLIS2 ELK1 ZNF143 RCOR1 SP3 ZBTB11 BCLAF3 MAP7D2 LOC729609
GH0XH020060 0.9 FANTOM5 ENCODE 13 +55.5 55473 1 ZNF687 RB1 IKZF1 EBF1 DPF2 IKZF2 RELA BCLAF3 MAP7D2 MIR23C
GH0XH019771 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +342.4 342427 7 HDGF PKNOX1 RB1 ZSCAN4 YBX1 EBF1 BATF RELA ZFHX2 EED SH3KBP1 BCLAF3 MAP7D2 RPS6KA3 GC0XP019714
GH0XH019964 0.6 ENCODE 11 +149.6 149629 5 FOXA2 JUNB BATF BCL11A IKZF1 PRDM10 ATF7 RUNX3 SPI1 BCLAF3 SH3KBP1 MAP7D2 GC0XM019967 GC0XP019949
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP7D2 on UCSC Golden Path with GeneCards custom track

Promoters for MAP7D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000245106 495 1000 DMAP1 ZBTB8A ZNF2 ZNF7 ZNF547 MBD1 NR2F6 ZBTB26 ZBTB20 TRIM28

Genomic Location for MAP7D2 Gene

Chromosome:
X
Start:
20,006,713 bp from pter
End:
20,116,996 bp from pter
Size:
110,284 bases
Orientation:
Minus strand

Genomic View for MAP7D2 Gene

Genes around MAP7D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP7D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP7D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP7D2 Gene

Proteins for MAP7D2 Gene

  • Protein details for MAP7D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T17-MA7D2_HUMAN
    Recommended name:
    MAP7 domain-containing protein 2
    Protein Accession:
    Q96T17
    Secondary Accessions:
    • B7Z2J8
    • B7Z3S7
    • B9EGC7
    • C9JMA4
    • C9JYW0
    • Q5EBN1
    • Q5JPS7
    • Q6PIC7
    • Q8N792

    Protein attributes for MAP7D2 Gene

    Size:
    732 amino acids
    Molecular mass:
    81965 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05407.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP7D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP7D2 Gene

Post-translational modifications for MAP7D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP7D2 Gene

Domains & Families for MAP7D2 Gene

Gene Families for MAP7D2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAP7D2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96T17

UniProtKB/Swiss-Prot:

MA7D2_HUMAN :
  • Belongs to the MAP7 family.
Family:
  • Belongs to the MAP7 family.
genes like me logo Genes that share domains with MAP7D2: view

Function for MAP7D2 Gene

Gene Ontology (GO) - Molecular Function for MAP7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
genes like me logo Genes that share ontologies with MAP7D2: view

Phenotypes for MAP7D2 Gene

genes like me logo Genes that share phenotypes with MAP7D2: view

Animal Model Products

CRISPR Products

miRNA for MAP7D2 Gene

miRTarBase miRNAs that target MAP7D2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP7D2 Gene

Localization for MAP7D2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP7D2 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IBA --
genes like me logo Genes that share ontologies with MAP7D2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP7D2 Gene

Pathways & Interactions for MAP7D2 Gene

SuperPathways for MAP7D2 Gene

No Data Available

Interacting Proteins for MAP7D2 Gene

Gene Ontology (GO) - Biological Process for MAP7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
genes like me logo Genes that share ontologies with MAP7D2: view

No data available for Pathways by source and SIGNOR curated interactions for MAP7D2 Gene

Drugs & Compounds for MAP7D2 Gene

No Compound Related Data Available

Transcripts for MAP7D2 Gene

Unigene Clusters for MAP7D2 Gene

MAP7 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP7D2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - -
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - -
SP9:
SP10: - - -
SP11: - - - -
SP12: -
SP13: - - - - - - -
SP14:
SP15: - - -

ExUns: 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MAP7D2 Gene

GeneLoc Exon Structure for
MAP7D2
ECgene alternative splicing isoforms for
MAP7D2

Expression for MAP7D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP7D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP7D2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.1), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for MAP7D2 Gene

This gene is overexpressed in Cervix (17.2), Testis (13.7), Monocytes (9.1), and Fetal Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP7D2 Gene



Protein tissue co-expression partners for MAP7D2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP7D2 Gene:

MAP7D2

SOURCE GeneReport for Unigene cluster for MAP7D2 Gene:

Hs.127951

Evidence on tissue expression from TISSUES for MAP7D2 Gene

  • Nervous system(4.9)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MAP7D2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP7D2 Gene

Orthologs for MAP7D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP7D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP7D2 33 34
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia MAP7D2 33 34
  • 86.32 (n)
mouse
(Mus musculus)
Mammalia Map7d2 33 16 34
  • 79.43 (n)
rat
(Rattus norvegicus)
Mammalia Map7d2 33
  • 79.43 (n)
cow
(Bos Taurus)
Mammalia MAP7D2 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP7D2 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP7D2 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP7D2 33 34
  • 69.57 (n)
lizard
(Anolis carolinensis)
Reptilia MAP7D2 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map7d2 33
  • 63.51 (n)
Str.7455 33
zebrafish
(Danio rerio)
Actinopterygii map7d2a 34
  • 31 (a)
OneToMany
map7d2b 34
  • 31 (a)
OneToMany
Species where no ortholog for MAP7D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP7D2 Gene

ENSEMBL:
Gene Tree for MAP7D2 (if available)
TreeFam:
Gene Tree for MAP7D2 (if available)

Paralogs for MAP7D2 Gene

Paralogs for MAP7D2 Gene

genes like me logo Genes that share paralogs with MAP7D2: view

Variants for MAP7D2 Gene

Sequence variations from dbSNP and Humsavar for MAP7D2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_035450 A breast cancer sample
rs1000001636 -- 20,096,442(+) AAAAA(A/G)AAAAA intron-variant
rs1000008761 -- 20,034,271(+) CTGGC(C/T)AGGTG intron-variant
rs1000066829 -- 20,056,834(+) ACTAC(C/G)CAGCC intron-variant
rs1000082521 -- 20,086,754(+) GGCAC(A/G)GTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP7D2 Gene

Variant ID Type Subtype PubMed ID
esv3573634 CNV loss 25503493
esv3573635 CNV loss 25503493
nsv425374 CNV deletion 16902084
nsv6827 CNV deletion 18451855

Variation tolerance for MAP7D2 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.25; 76.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP7D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP7D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP7D2 Gene

Disorders for MAP7D2 Gene

Relevant External Links for MAP7D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP7D2

No disorders were found for MAP7D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP7D2 Gene

Publications for MAP7D2 Gene

  1. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 3 4 60
  2. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 3 4 60
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60

Products for MAP7D2 Gene

Sources for MAP7D2 Gene

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