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Aliases for MAP7D2 Gene

Aliases for MAP7D2 Gene

  • MAP7 Domain Containing 2 2 3 5

External Ids for MAP7D2 Gene

Previous GeneCards Identifiers for MAP7D2 Gene

  • GC0XM019935
  • GC0XM017770

Summaries for MAP7D2 Gene

GeneCards Summary for MAP7D2 Gene

MAP7D2 (MAP7 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is MAP7D1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP7D2 Gene

Genomics for MAP7D2 Gene

Regulatory Elements for MAP7D2 Gene

Promoters for MAP7D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAP7D2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP7D2 Gene

Chromosome:
X
Start:
20,006,713 bp from pter
End:
20,116,996 bp from pter
Size:
110,284 bases
Orientation:
Minus strand

Genomic View for MAP7D2 Gene

Genes around MAP7D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP7D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP7D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP7D2 Gene

Proteins for MAP7D2 Gene

  • Protein details for MAP7D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T17-MA7D2_HUMAN
    Recommended name:
    MAP7 domain-containing protein 2
    Protein Accession:
    Q96T17
    Secondary Accessions:
    • B7Z2J8
    • B7Z3S7
    • B9EGC7
    • C9JMA4
    • C9JYW0
    • Q5EBN1
    • Q5JPS7
    • Q6PIC7
    • Q8N792

    Protein attributes for MAP7D2 Gene

    Size:
    732 amino acids
    Molecular mass:
    81965 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05407.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP7D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP7D2 Gene

Proteomics data for MAP7D2 Gene at MOPED

Post-translational modifications for MAP7D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP7D2 Gene

No data available for DME Specific Peptides for MAP7D2 Gene

Domains & Families for MAP7D2 Gene

Protein Domains for MAP7D2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96T17

UniProtKB/Swiss-Prot:

MA7D2_HUMAN :
  • Belongs to the MAP7 family.
Family:
  • Belongs to the MAP7 family.
genes like me logo Genes that share domains with MAP7D2: view

No data available for Gene Families for MAP7D2 Gene

Function for MAP7D2 Gene

Phenotypes for MAP7D2 Gene

genes like me logo Genes that share phenotypes with MAP7D2: view

miRNA for MAP7D2 Gene

miRTarBase miRNAs that target MAP7D2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP7D2 Gene

Localization for MAP7D2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP7D2 Gene COMPARTMENTS Subcellular localization image for MAP7D2 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAP7D2 Gene

Pathways & Interactions for MAP7D2 Gene

SuperPathways for MAP7D2 Gene

No Data Available

Interacting Proteins for MAP7D2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368964%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000334499%0d%0a
Selected Interacting proteins: ENSP00000368964 Q96T17-MA7D2_HUMAN for MAP7D2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MAP7D2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAP7D2 Gene

Drugs & Compounds for MAP7D2 Gene

No Compound Related Data Available

Transcripts for MAP7D2 Gene

Unigene Clusters for MAP7D2 Gene

MAP7 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP7D2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - -
SP7: - - - - - - - - - - - - - - - - -
SP8: - - - -
SP9:
SP10: - - -
SP11: - - - -
SP12: -
SP13: - - - - - - -
SP14:
SP15: - - -

ExUns: 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MAP7D2 Gene

GeneLoc Exon Structure for
MAP7D2
ECgene alternative splicing isoforms for
MAP7D2

Expression for MAP7D2 Gene

mRNA expression in normal human tissues for MAP7D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP7D2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.1), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Cortex (x4.9).

Protein differential expression in normal tissues from HIPED for MAP7D2 Gene

This gene is overexpressed in Cervix (17.2), Testis (13.7), Monocytes (9.1), and Fetal Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MAP7D2 Gene



SOURCE GeneReport for Unigene cluster for MAP7D2 Gene Hs.127951

genes like me logo Genes that share expression patterns with MAP7D2: view

Protein tissue co-expression partners for MAP7D2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MAP7D2 Gene

Orthologs for MAP7D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP7D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP7D2 36
  • 98 (a)
OneToOne
MAP7D2 35
  • 99.13 (n)
  • 98.96 (a)
cow
(Bos Taurus)
Mammalia MAP7D2 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP7D2 36
  • 83 (a)
OneToOne
MAP7D2 35
  • 86.32 (n)
  • 82.77 (a)
mouse
(Mus musculus)
Mammalia Map7d2 16
Map7d2 36
  • 70 (a)
OneToOne
Map7d2 35
  • 79.43 (n)
  • 75.29 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP7D2 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP7D2 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map7d2 35
  • 79.43 (n)
  • 74.81 (a)
chicken
(Gallus gallus)
Aves MAP7D2 35
  • 69.57 (n)
  • 64.56 (a)
MAP7D2 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP7D2 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map7d2 35
  • 63.51 (n)
  • 57.04 (a)
Str.7455 35
zebrafish
(Danio rerio)
Actinopterygii map7d2a 36
  • 31 (a)
OneToMany
map7d2b 36
  • 31 (a)
OneToMany
Species with no ortholog for MAP7D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP7D2 Gene

ENSEMBL:
Gene Tree for MAP7D2 (if available)
TreeFam:
Gene Tree for MAP7D2 (if available)

Paralogs for MAP7D2 Gene

Paralogs for MAP7D2 Gene

genes like me logo Genes that share paralogs with MAP7D2: view

Variants for MAP7D2 Gene

Sequence variations from dbSNP and Humsavar for MAP7D2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs34519770 - 20,052,928(+) GTTTA(C/T)TCATG intron-variant, reference, missense
VAR_035450 A breast cancer sample
rs4077051 -- 20,020,808(+) GCCTG(C/G)CTACG intron-variant, downstream-variant-500B
rs4403568 -- 20,028,197(-) gctta(A/C/G/T)agagg intron-variant
rs4370706 -- 20,084,788(+) GGTCT(C/T)GAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP7D2 Gene

Variant ID Type Subtype PubMed ID
nsv6827 CNV Loss 18451855
nsv425374 CNV Loss 16902084

Variation tolerance for MAP7D2 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.25; 76.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP7D2 Gene

HapMap Linkage Disequilibrium report
MAP7D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP7D2 Gene

Disorders for MAP7D2 Gene

Relevant External Links for MAP7D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP7D2

No disorders were found for MAP7D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP7D2 Gene

Publications for MAP7D2 Gene

  1. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for MAP7D2 Gene

Sources for MAP7D2 Gene

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