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Aliases for MAP7D1 Gene

Aliases for MAP7D1 Gene

  • MAP7 Domain Containing 1 2 3 5
  • Arginine/Proline-Rich Coiled-Coil Domain-Containing Protein 1 3 4
  • Proline/Arginine-Rich Coiled-Coil Domain-Containing Protein 1 3 4
  • Proline Arginine Rich Coiled Coil 1 2 3
  • Arginine/Proline Rich Coiled-Coil 1 2 3
  • PARCC1 3 4
  • RPRC1 3 4
  • KIAA1187 4

External Ids for MAP7D1 Gene

Previous HGNC Symbols for MAP7D1 Gene

  • PARCC1
  • RPRC1

Previous GeneCards Identifiers for MAP7D1 Gene

  • GC01P036395
  • GC01P036621
  • GC01P034738

Summaries for MAP7D1 Gene

GeneCards Summary for MAP7D1 Gene

MAP7D1 (MAP7 Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is MAP7D2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP7D1 Gene

Genomics for MAP7D1 Gene

Regulatory Elements for MAP7D1 Gene

Enhancers for MAP7D1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAP7D1 on UCSC Golden Path with GeneCards custom track

Promoters for MAP7D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAP7D1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP7D1 Gene

Chromosome:
1
Start:
36,155,579 bp from pter
End:
36,180,849 bp from pter
Size:
25,271 bases
Orientation:
Plus strand

Genomic View for MAP7D1 Gene

Genes around MAP7D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP7D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP7D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP7D1 Gene

Proteins for MAP7D1 Gene

  • Protein details for MAP7D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KQU3-MA7D1_HUMAN
    Recommended name:
    MAP7 domain-containing protein 1
    Protein Accession:
    Q3KQU3
    Secondary Accessions:
    • D3DPS4
    • Q7L8J5
    • Q8N905
    • Q8TAK0
    • Q9HBQ2
    • Q9NW29
    • Q9ULN3

    Protein attributes for MAP7D1 Gene

    Size:
    841 amino acids
    Molecular mass:
    92820 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG17244.1; Type=Frameshift; Positions=80, 207, 736; Evidence={ECO:0000305}; Sequence=BAA86501.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP7D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP7D1 Gene

Proteomics data for MAP7D1 Gene at MOPED

Post-translational modifications for MAP7D1 Gene

  • Ubiquitination at Lys 268, Lys 272, and Lys 439
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP7D1 Gene

No data available for DME Specific Peptides for MAP7D1 Gene

Domains & Families for MAP7D1 Gene

Protein Domains for MAP7D1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q3KQU3

UniProtKB/Swiss-Prot:

MA7D1_HUMAN :
  • Belongs to the MAP7 family.
Family:
  • Belongs to the MAP7 family.
genes like me logo Genes that share domains with MAP7D1: view

No data available for Gene Families for MAP7D1 Gene

Function for MAP7D1 Gene

genes like me logo Genes that share phenotypes with MAP7D1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP7D1 Gene

Localization for MAP7D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP7D1 Gene

Cytoplasm, cytoskeleton, spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP7D1 Gene COMPARTMENTS Subcellular localization image for MAP7D1 gene
Compartment Confidence
cytoskeleton 3
nucleus 3

Gene Ontology (GO) - Cellular Components for MAP7D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IEA,IBA --
genes like me logo Genes that share ontologies with MAP7D1: view

Pathways & Interactions for MAP7D1 Gene

SuperPathways for MAP7D1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP7D1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAP7D1 Gene

Drugs & Compounds for MAP7D1 Gene

No Compound Related Data Available

Transcripts for MAP7D1 Gene

Unigene Clusters for MAP7D1 Gene

MAP7 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP7D1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for MAP7D1 Gene

GeneLoc Exon Structure for
MAP7D1
ECgene alternative splicing isoforms for
MAP7D1

Expression for MAP7D1 Gene

mRNA expression in normal human tissues for MAP7D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP7D1 Gene

This gene is overexpressed in Bone marrow stromal cell (13.8), Peripheral blood mononuclear cells (11.7), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP7D1 Gene



SOURCE GeneReport for Unigene cluster for MAP7D1 Gene Hs.356096

genes like me logo Genes that share expression patterns with MAP7D1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MAP7D1 Gene

Orthologs for MAP7D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP7D1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP7D1 35
  • 89.84 (n)
  • 89.08 (a)
MAP7D1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP7D1 35
  • 87.66 (n)
  • 88.2 (a)
MAP7D1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map7d1 35
  • 87.07 (n)
  • 87.11 (a)
Map7d1 16
Map7d1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAP7D1 35
  • 98.95 (n)
  • 98.77 (a)
MAP7D1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map7d1 35
  • 86.77 (n)
  • 86.85 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP7D1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP7D1 35
  • 66.9 (n)
  • 62.12 (a)
MAP7D1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP7D1 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rprc1 35
  • 60.35 (n)
  • 60.35 (a)
Str.10677 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15665 35
zebrafish
(Danio rerio)
Actinopterygii Dr.6204 35
map7d1a 36
  • 47 (a)
OneToMany
map7d1a 36
  • 47 (a)
OneToMany
map7d1b 36
  • 45 (a)
OneToMany
Species with no ortholog for MAP7D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP7D1 Gene

ENSEMBL:
Gene Tree for MAP7D1 (if available)
TreeFam:
Gene Tree for MAP7D1 (if available)

Paralogs for MAP7D1 Gene

Paralogs for MAP7D1 Gene

(2) SIMAP similar genes for MAP7D1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MAP7D1: view

Variants for MAP7D1 Gene

Sequence variations from dbSNP and Humsavar for MAP7D1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2296266 - 36,171,234(-) ATCCC(A/G)TGGGC reference, missense
rs12563354 - 36,178,084(+) GCAAG(A/C/G/T)GCAGG reference, missense
rs166634 -- 36,168,273(-) TCTGT(C/T)GCCAG intron-variant
rs272811 -- 36,168,813(-) gtagc(C/T)atcat intron-variant
rs272812 -- 36,168,222(-) tgcct(C/G)ccagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP7D1 Gene

Variant ID Type Subtype PubMed ID
nsv871396 CNV Gain 21882294
nsv834691 CNV Loss 17160897
nsv871804 CNV Loss 21882294
nsv870558 CNV Loss 21882294
dgv47e1 CNV Complex 17122850
esv2671242 CNV Deletion 23128226
nsv871426 CNV Loss 21882294
esv2746819 CNV Deletion 23290073
esv2671893 CNV Deletion 23128226

Variation tolerance for MAP7D1 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.84; 79.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAP7D1 Gene

Disorders for MAP7D1 Gene

Relevant External Links for MAP7D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP7D1

No disorders were found for MAP7D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP7D1 Gene

Publications for MAP7D1 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3

Products for MAP7D1 Gene

Sources for MAP7D1 Gene

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