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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP7 Gene

protein-coding   GIFtS: 50
GCID: GC06M136663

microtubule-associated protein 7
 Explore 8 diseases affiliated with
MAP7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP7    

Aliases
for MAP7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Microtubule-Associated Protein 71 2 3     EMAP1152 5
E-MAP-1151 2 3     DJ325F22.2 (Microtubule-Associated Protein 7 (EMAP115, E-MAP-115))2
Epithelial Microtubule-Associated Protein Of 115 KDa2 3     Ensconsin1
MAP-72 3     

External Ids:    HGNC: 68691   Entrez Gene: 90532   Ensembl: ENSG000001355257   OMIM: 6041085   UniProtKB: Q142443   

Export aliases for MAP7 gene to outside databases

Previous GC identifers: GC06M136287 GC06M136510 GC06M136599 GC06M136644 GC06M136645 GC06M136705 GC06M134228


Summaries
for MAP7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAP7:
The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial
origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for
cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve
to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in
microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: MAP7_HUMAN, Q14244
Function: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during
polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a
role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4
toward the membrane and may link cytoskeletal microfilaments

Gene Wiki entry for MAP7


Genomic Views
for MAP7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP7 gene promoter:
         AhR   AML1a   Olf-1   GATA-1   Arnt   RORalpha1   POU2F1   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.3   Ensembl cytogenetic band:  6q23.3   HGNC cytogenetic band: 6q23.2

MAP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M136663:  view genomic region     (about GC identifiers)

Start:
 136,663,872 bp from pter      End:
 136,871,792 bp from pter
Size:
 207,921 bases      Orientation:
 minus strand

Proteins
for MAP7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAP7_HUMAN, Q14244 (See protein sequence)
Recommended Name: Ensconsin  
Size: 749 amino acids; 84052 Da
Subunit: Interacts with TRPV4 (By similarity)
Subcellular location: Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton.
Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte
terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in
spike-like bundles facing intercellular contacts
Secondary accessions: B7Z290 B7Z9U7 C9JPS0 Q7Z6S0 Q8TAU5 Q9NY82 Q9NY83
Alternative splicing: 5 isoforms:  Q14244-1   Q14244-2   Q14244-3   Q14244-4   Q14244-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP7: NX_Q14244

Post-translational modifications:

  • The association with microtubules is regulated by phosphorylation during the cell cycle. During interphase only
    • phosphorylated on serine. Phosphorylated on threonine in mitosis1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14244

    • MAP7 Protein expression data from MOPED and PaxDb:    About this image 
    MAP7 Protein Expression
    REFSEQ proteins (10 alternative transcripts): 
    NP_001185537.1  NP_001185538.1  NP_001185540.1  NP_001185543.1  NP_001185544.1  NP_001185545.1  NP_001185546.1  NP_001185547.1  
    NP_001185548.1  NP_003971.1  

    ENSEMBL proteins: 
     ENSP00000346581   ENSP00000414712   ENSP00000400790   ENSP00000445737   ENSP00000414879  

    Human Recombinant Protein Products for MAP7: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAP7

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex TAS8408219
    GO:0005886plasma membrane ----
    GO:0015630microtubule cytoskeleton IDA--

    MAP7 for ontologies           About GeneDecksing



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    Assay Products for MAP7: 
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    Uscn ELISAs and CLIAs for MAP7

    Protein Domains /
    Families
    for MAP7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP7 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008604 E-MAP-115

    Graphical View of Domain Structure for InterPro Entry Q14244

    ProtoNet protein and cluster: Q14244

    UniProtKB/Swiss-Prot: MAP7_HUMAN, Q14244
    Similarity: Belongs to the MAP7 family


    Function
    for MAP7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAP7_HUMAN, Q14244
    Function: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during
    polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a
    role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4
    toward the membrane and may link cytoskeletal microfilaments
    Induction: Up-regulated upon terminal differentiation of primary keratinocytes

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ISS--
    GO:0005198structural molecule activity TAS8408219
    GO:0005515protein binding ----
         
    MAP7 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Map7):
     endocrine/exocrine gland  immune system  reproductive system 

    MAP7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MAP7 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MAP7
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP7
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP7 (see all 57):
    hsa-miR-549 hsa-miR-323-3p hsa-miR-106a hsa-miR-15a hsa-miR-218-1* hsa-miR-301a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: MAP7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP7 (see all 4)
    OriGene shRNA RFP: MAP7
    OriGene siRNA: MAP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP7
    Sirion Biotech Custom design and validation of potent shRNA sequences against MAP7 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAP7
    Sirion Biotech Customized adenovirus for overexpression of MAP7 
    Sirion Biotech Customized adenovirus for potent knockdown of MAP7

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP7 (see all 9)
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    Cell Line
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    Sirion Biotech Customized inducible overexpressing cell line services for MAP7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP7


    Pathways & Interactions
    for MAP7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/534 Interacting proteins for MAP7 (Q142442, 3 ENSP000003465814) via UniProtKB, MINT, STRING, and/or I2D (see all 534)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRPV4Q9HBA03, ENSP000002617404I2D: score=2 STRING: ENSP00000261740
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    DVL2O146413I2D: score=1 
    DVL3Q929973I2D: score=1 
    PCBD1P614573I2D: score=1 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization TAS8408219
    GO:0000902cell morphogenesis ----
    GO:0001578microtubule bundle formation ----
    GO:0006687glycosphingolipid metabolic process ----
    GO:0006970response to osmotic stress ISS--

    MAP7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP7
    1 Novoseek chemical compound relationship for MAP7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paclitaxel 36.7 3 11668581 (2)

    Search CenterWatch for drugs/clinical trials and news about MAP7 

    Transcripts
    for MAP7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP7 gene (10 alternative transcripts): 
    NM_001198608.1  NM_001198609.1  NM_001198611.1  NM_001198614.1  NM_001198615.1  NM_001198616.1  NM_001198617.1  NM_001198618.1  
    NM_001198619.1  NM_003980.4  

    Unigene Cluster for MAP7:

    Microtubule-associated protein 7
    Hs.486548  [show with all ESTs]
    Unigene Representative Sequence: NM_003980
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354570(uc011edf.2 uc010kgu.3 uc011edg.2 uc011edh.2 uc010kgv.3 uc010kgs.3 uc011edi.2 uc010kgq.2 uc003qgz.3 uc003qha.2)
    ENST00000454590(uc010kgt.2) ENST00000438100 ENST00000544465 ENST00000432797(uc010kgr.2)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP7
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP7 (see all 57):
    hsa-miR-549 hsa-miR-323-3p hsa-miR-106a hsa-miR-15a hsa-miR-218-1* hsa-miR-301a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: MAP7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP7 (see all 4)
    OriGene shRNA RFP: MAP7
    OriGene siRNA: MAP7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP7
    Sirion Biotech Custom design and validation of potent shRNA sequences against MAP7 
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP7 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP7

    Additional cDNA sequence: 

    AJ242501.1 AJ242502.1 AJ420541.1 AK294461.1 AK295749.1 AK296483.1 AK296556.1 AK299355.1 
    AK307873.1 AK311114.1 AK311227.1 AK311234.1 AK311236.1 AK311270.1 AK312789.1 AK316062.1 
    AK316529.1 BC025777.1 X73882.1 

    14 DOTS entries:

    DT.97841077  DT.100770276  DT.100770312  DT.317008  DT.95240153  DT.86858952  DT.99994863  DT.121372310 
    DT.86849853  DT.91951779  DT.101960650  DT.121372306  DT.40114616  DT.97815835 

    24/156 AceView cDNA sequences (see all 156):

    CB158648 BG656248 AI439098 AA470051 AJ242502 BE219849 AI565221 AA488545 
    AA701579 CA433232 AA779409 BU168222 AU106100 AA535982 BE222222 AW263065 
    BX098491 BQ029455 BM840395 NM_003980 AL698924 AA939180 CB151084 AI924310 

    GeneLoc Exon Structure


    Expression
    for MAP7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAACACCAAA
    MAP7 Expression
    About this image

    MAP7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP7

    SOURCE GeneReport for Unigene cluster: Hs.486548

    UniProtKB/Swiss-Prot: MAP7_HUMAN, Q14244
    Tissue specificity: Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal
    layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell
    carcinomas

        SABiosciences Custom PCR Arrays for MAP7
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP7

    Orthologs
    for MAP7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAP7 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAP71 microtubule-associated protein 7 69.64(n)
    69.06(a)    		   421689  NM_001031072.1  NP_001026243.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAP76
    		 --
    		 59(a)
    		 1 ↔ 1
    		 GL343200.1(2406939-2455399)
    zebrafish
    (Danio rerio)    		 Actinopterygii BQ074316.12   -- 82.08(n)    BQ074316.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ens1 ensconsin 39.93(n)
    30.28(a)    		   38491  NM_168061.2  NP_728938.2 


    ENSEMBL Gene Tree for MAP7 (if available)
    TreeFam Gene Tree for MAP7 (if available) 

    Paralogs
    for MAP7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP7 gene
    MAP7D22  INCENP2  MAP7D32  MAP7D12  
    3 SIMAP similar genes for MAP7 using alignment to 3 protein entries:     MAP7_HUMAN (see all proteins):
    MAP7D1    RPRC1    MAP7D2

    MAP7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MAP7
    PGOHUM00000235098 PGOHUM00000243985


    Genomic Variants
    for MAP7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3166 NCBI SNPs in MAP7 are shown (see all 3166)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1127328831,2
    		--136663005(+) TTATAG/ATATCT 10 -- ds50012Minor allele frequency- A:0.04CSA WA 120
    rs20380821,2
    		C,F,A,H--136663008(+) TAGTAC/TCTCAG 10 -- ds500132Minor allele frequency- T:0.16NA EA NS WA CSA 3848
    rs1833536281,2
    		--136663027(+) ATCTCC/TTTGCC 10 -- ds50010--------
    rs1878352461,2
    		--136663066(+) ACACGC/TTTATG 10 -- ds50010--------
    rs1911519961,2
    		--136663178(+) GGTTAC/TTTAGG 10 -- ds50010--------
    rs1409011821,2
    		--136663241(+) TTGTCA/GTATAG 10 -- ds50010--------
    rs1501341501,2
    		--136663304(+) ATGTAA/GGAGGA 10 -- ds50010--------
    rs1824728831,2
    		--136663509(+) TTAAGC/GTCTGC 10 -- ut310--------
    rs1879330901,2
    		--136663527(+) TATAGA/TTTTTT 10 -- ut310--------
    rs1387972101,2
    		--136663610(+) ACAATA/TTAATT 10 -- ut310--------

    HapMap Linkage Disequilibrium report for MAP7 (136663872 - 136871792 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 15 variations for MAP7
         10 CNVs: 81603 44230 64667 99723 59299 94041 64668 62581 94043 81602
         5 Indels: 81604 94046 94042 94045 94044

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    Disorders / Diseases
    for MAP7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP7 for disorders           About GeneDecksing

    OMIM gene information: 604108    OMIM disorders: --

    8 diseases for MAP7:    About MalaCards
    basal cell carcinoma    intrahepatic cholangiocarcinoma    barrett's adenocarcinoma    squamous cell carcinoma
    cholangiocarcinoma    colon cancer    carcinoma    adenocarcinoma

    Human Genome Epidemiology (HuGE) Navigator: MAP7 (4 documents)

    Export disorders for MAP7 gene to outside databases

    Publications
    for MAP7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP7 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with MAP7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells. (PubMed id 8408219)1, 2, 3, 9 Masson D. and Kreis T.E. (1993)
    2. Binding of E-MAP-115 to microtubules is regulated by cell cycle- dependent phosphorylation. (PubMed id 7490279)1, 2, 9 Masson D. and Kreis T.E. (1995)
    3. Upregulation and redistribution of E-MAP-115 (epithelial microtubule- associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts. (PubMed id 9989799)1, 2, 9 Fabre-Jonca N.... Masson D. (1999)
    4. Rapid dynamics of the microtubule binding of ensconsin in vivo. (PubMed id 11719555)1, 2, 9 Bulinski J.C....Waterman-Storer C.M. (2001)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Expression and distribution of distinct variants of E-MAP-115 during proliferation and differentiation of human intestinal epithelial cells. (PubMed id 12845596)1, 9 Vanier M.T....Launay J.F. (2003)
    9. The expression ratio of Map7/B2M is prognostic for survival in patients with stage II colon cancer. (PubMed id 18695889)1, 9 Blum C....Mitas M. (2008)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    External Searches for MAP7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing MAP7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9053 HGNC: 6869 AceView: MAP7 Ensembl:ENSG00000135525 euGenes: HUgn9053
    ECgene: MAP7 H-InvDB: MAP7

    Other Databases showing MAP7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAP7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAP7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP7 gene:
    Search GeneIP for patents involving MAP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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