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Aliases for MAP7 Gene

Aliases for MAP7 Gene

  • Microtubule-Associated Protein 7 2 3 4
  • Epithelial Microtubule-Associated Protein Of 115 KDa 3 4
  • E-MAP-115 3 4
  • EMAP115 3 6
  • MAP-7 3 4
  • DJ325F22.2 (Microtubule-Associated Protein 7 (EMAP115, E-MAP-115)) 3
  • Ensconsin 3

External Ids for MAP7 Gene

Summaries for MAP7 Gene

Entrez Gene Summary for MAP7 Gene

  • The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for MAP7 Gene

MAP7 (Microtubule-Associated Protein 7) is a Protein Coding gene. GO annotations related to this gene include receptor binding and structural molecule activity. An important paralog of this gene is MAP7D1.

UniProtKB/Swiss-Prot for MAP7 Gene

  • Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.

Gene Wiki entry for MAP7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP7 Gene

Genomics for MAP7 Gene

Genomic Location for MAP7 Gene

Start:
136,342,281 bp from pter
End:
136,551,009 bp from pter
Size:
208,729 bases
Orientation:
Minus strand

Genomic View for MAP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP7 Gene

Regulatory Elements for MAP7 Gene

Proteins for MAP7 Gene

  • Protein details for MAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14244-MAP7_HUMAN
    Recommended name:
    Ensconsin
    Protein Accession:
    Q14244
    Secondary Accessions:
    • B7Z290
    • B7Z400
    • B7Z5S7
    • B7Z9U7
    • C9JPS0
    • E9PCP3
    • F5H1E2
    • Q7Z6S0
    • Q8TAU5
    • Q9NY82
    • Q9NY83

    Protein attributes for MAP7 Gene

    Size:
    749 amino acids
    Molecular mass:
    84052 Da
    Quaternary structure:
    • Interacts with TRPV4.

    Alternative splice isoforms for MAP7 Gene

neXtProt entry for MAP7 Gene

Proteomics data for MAP7 Gene at MOPED

Post-translational modifications for MAP7 Gene

  • The association with microtubules is regulated by phosphorylation during the cell cycle. During interphase only phosphorylated on serine. Phosphorylated on threonine in mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP7 Gene

Domains for MAP7 Gene

Protein Domains for MAP7 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MAP7_HUMAN
Family:
  • Belongs to the MAP7 family.:
    • Q14244
genes like me logo Genes that share domains with MAP7: view

No data available for Gene Families for MAP7 Gene

Function for MAP7 Gene

Molecular function for MAP7 Gene

UniProtKB/Swiss-Prot Function: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.
UniProtKB/Swiss-Prot Induction: Up-regulated upon terminal differentiation of primary keratinocytes

Gene Ontology (GO) - Molecular Function for MAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding ISS --
GO:0005198 structural molecule activity TAS 8408219
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MAP7: view
genes like me logo Genes that share phenotypes with MAP7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAP7 Gene

Localization for MAP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP7 Gene

Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP7 Gene COMPARTMENTS Subcellular localization image for MAP7 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for MAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 8408219
GO:0005886 plasma membrane --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with MAP7: view

Pathways for MAP7 Gene

SuperPathways for MAP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0000902 cell morphogenesis --
GO:0001578 microtubule bundle formation --
GO:0006687 glycosphingolipid metabolic process --
GO:0006970 response to osmotic stress ISS --
genes like me logo Genes that share ontologies with MAP7: view

No data available for Pathways by source for MAP7 Gene

Compounds for MAP7 Gene

(9) ApexBio Compounds for MAP7 Gene

Compound Action Cas Number
7-xylosyltaxol taxol (Paclitaxel) derivative [90332-66-4]
Colchicine Colchicine, a tubulin Inhibitor [64-86-8]
D-64131 novel inhibitor of Tubulin polymerization [74588-78-6]
Docetaxel Trihydrate inhibitor of depolymerisation of microtubules [148408-66-6]
Mc-MMAD Potent tubulin inhibitor [1401963-15-2]
MMAD Potent tubulin inhibitor [203849-91-6]
Monomethyl auristatin E Antimitotic agent [474645-27-7]
Podophyllotoxin Actions Inhibits microtubule assembly [518-28-5]
Vc-MMAD antibody drug conjugate. [1401963-17-4]

(1) Novoseek inferred chemical compound relationships for MAP7 Gene

Compound -log(P) Hits PubMed IDs
paclitaxel 36.7 2
genes like me logo Genes that share compounds with MAP7: view

Transcripts for MAP7 Gene

Unigene Clusters for MAP7 Gene

Microtubule-associated protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP7 Gene

No ASD Table

Relevant External Links for MAP7 Gene

GeneLoc Exon Structure for
MAP7
ECgene alternative splicing isoforms for
MAP7

Expression for MAP7 Gene

mRNA expression in normal human tissues for MAP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP7 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP7 Gene

SOURCE GeneReport for Unigene cluster for MAP7 Gene Hs.486548

mRNA Expression by UniProt/SwissProt for MAP7 Gene

Q14244-MAP7_HUMAN
Tissue specificity: Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas.
genes like me logo Genes that share expressions with MAP7: view

Orthologs for MAP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP7 36
  • 96.41 (n)
  • 94.95 (a)
MAP7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP7 36
  • 86.49 (n)
  • 84.87 (a)
MGC151537 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP7 36
  • 87.99 (n)
  • 87.07 (a)
MAP7 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map7 36
  • 81.49 (n)
  • 79.78 (a)
Map7 16
Map7 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP7 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map7 36
  • 81.08 (n)
  • 78.45 (a)
chicken
(Gallus gallus)
Aves MAP7 36
  • 68.4 (n)
  • 67.05 (a)
MAP7 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP7 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497841 36
  • 60.34 (n)
  • 53.6 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC563520 36
  • 56.23 (n)
  • 53.27 (a)
MAP7 (1 of 2) 37
  • 44 (a)
OneToMany
MAP7 (2 of 2) 37
  • 33 (a)
OneToMany
Species with no ortholog for MAP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP7 Gene

ENSEMBL:
Gene Tree for MAP7 (if available)
TreeFam:
Gene Tree for MAP7 (if available)

Paralogs for MAP7 Gene

Paralogs for MAP7 Gene

Selected SIMAP similar genes for MAP7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MAP7 Gene

genes like me logo Genes that share paralogs with MAP7: view

Variants for MAP7 Gene

Sequence variations from dbSNP and Humsavar for MAP7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1681 -- 136,342,810(+) AACAG(A/C)TTTCT utr-variant-3-prime
rs2192 -- 136,469,039(+) ACAGC(C/T)GAATG intron-variant
rs14460 -- 136,342,880(+) AATGT(C/T)TTCAC utr-variant-3-prime
rs15569 -- 136,343,490(-) CATTA(C/T)AAATT utr-variant-3-prime
rs720565 -- 136,471,826(-) GGAAG(C/G)CTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP7 Gene

Variant ID Type Subtype PubMed ID
nsv464064 CNV Loss 19166990
esv2665783 CNV Deletion 23128226
esv2670575 CNV Deletion 23128226
esv27134 CNV Loss 19812545
esv2614575 CNV Deletion 19546169
esv2067162 CNV Deletion 18987734
esv2732763 CNV Deletion 23290073
dgv1065n67 CNV Loss 20364138
esv24386 CNV Loss 19812545
dgv1154e199 CNV Deletion 23128226
esv6777 CNV Loss 19470904
nsv820004 CNV Loss 19587683
esv2666931 CNV Deletion 23128226

Relevant External Links for MAP7 Gene

HapMap Linkage Disequilibrium report
MAP7

Disorders for MAP7 Gene

Relevant External Links for MAP7

Genetic Association Database (GAD)
MAP7
Human Genome Epidemiology (HuGE) Navigator
MAP7
genes like me logo Genes that share disorders with MAP7: view

No data available for UniProtKB/Swiss-Prot for MAP7 Gene

Publications for MAP7 Gene

  1. Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells. (PMID: 8408219) Masson D. … Kreis T.E. (J. Cell Biol. 1993) 2 3 4 23
  2. Upregulation and redistribution of E-MAP-115 (epithelial microtubule- associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts. (PMID: 9989799) Fabre-Jonca N. … Masson D. (J. Invest. Dermatol. 1999) 3 4 23
  3. Rapid dynamics of the microtubule binding of ensconsin in vivo. (PMID: 11719555) Bulinski J.C. … Waterman-Storer C.M. (J. Cell Sci. 2001) 3 4 23
  4. Binding of E-MAP-115 to microtubules is regulated by cell cycle- dependent phosphorylation. (PMID: 7490279) Masson D. … Kreis T.E. (J. Cell Biol. 1995) 3 4 23
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for MAP7 Gene

  • Addgene plasmids for MAP7

Sources for MAP7 Gene

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