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Aliases for MAP7 Gene

Aliases for MAP7 Gene

  • Microtubule Associated Protein 7 2 3 5
  • Epithelial Microtubule-Associated Protein Of 115 KDa 3 4
  • E-MAP-115 3 4
  • MAP-7 3 4
  • DJ325F22.2 (Microtubule-Associated Protein 7 (EMAP115, E-MAP-115)) 3
  • Microtubule-Associated Protein 7 4
  • Ensconsin 3
  • EMAP115 3

External Ids for MAP7 Gene

Previous GeneCards Identifiers for MAP7 Gene

  • GC06M136287
  • GC06M136510
  • GC06M136599
  • GC06M136644
  • GC06M136645
  • GC06M136705
  • GC06M134228
  • GC06M136663

Summaries for MAP7 Gene

Entrez Gene Summary for MAP7 Gene

  • The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for MAP7 Gene

MAP7 (Microtubule Associated Protein 7) is a Protein Coding gene. GO annotations related to this gene include receptor binding and structural molecule activity. An important paralog of this gene is MAP7D1.

UniProtKB/Swiss-Prot for MAP7 Gene

  • Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.

Gene Wiki entry for MAP7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP7 Gene

Genomics for MAP7 Gene

Regulatory Elements for MAP7 Gene

Enhancers for MAP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G136585 1.3 FANTOM5 Ensembl ENCODE 29.3 -36.1 -36115 2.7 ZSCAN4 ZNF175 CEBPG ZNF664 ZNF316 ZNF157 ZSCAN5C SCRT2 FOS NFE2 MAP7 LOC101928461 RNA5SP219
GH06G136525 0.9 ENCODE dbSUPER 42.2 +26.3 26262 0.2 ZBTB21 INSM2 ZEB2 ZNF843 ATF2 ZNF101 ZSCAN21 PRDM6 ATF3 ZNF366 MAP7 BCLAF1 RN7SKP299 NDUFS5P1
GH06G136416 1 dbSUPER 35.8 +131.1 131089 5.8 PKNOX1 ATF1 YY1 TCF12 ZNF766 GATA2 KLF13 CAVIN1 REST ZNF592 MAP7 ENSG00000216613 RPLP1P8
GH06G136438 1.4 Ensembl ENCODE dbSUPER 23.9 +110.9 110911 3.2 HDAC1 HDGF PKNOX1 YY1 GATA2 SCRT2 IKZF2 EGR2 CEBPB GATAD2B MAP7 ENSG00000216613 NDUFS5P1
GH06G136548 1 ENCODE 30.2 +0.7 738 3.1 ATF1 CREB3L1 SIN3A ZNF2 ZNF48 YY1 ETS1 ZNF121 GLIS2 ELK1 MAP7 ENSG00000272189 RN7SKP299
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP7 on UCSC Golden Path with GeneCards custom track

Promoters for MAP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000203507 718 1800 ATF1 CREB3L1 SIN3A ZNF2 YY1 ETS1 ZNF121 GLIS2 ELK1 ZNF143

Genomic Location for MAP7 Gene

Chromosome:
6
Start:
136,342,281 bp from pter
End:
136,550,819 bp from pter
Size:
208,539 bases
Orientation:
Minus strand

Genomic View for MAP7 Gene

Genes around MAP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP7 Gene

Proteins for MAP7 Gene

  • Protein details for MAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14244-MAP7_HUMAN
    Recommended name:
    Ensconsin
    Protein Accession:
    Q14244
    Secondary Accessions:
    • B7Z290
    • B7Z400
    • B7Z5S7
    • B7Z9U7
    • C9JPS0
    • E9PCP3
    • F5H1E2
    • Q7Z6S0
    • Q8TAU5
    • Q9NY82
    • Q9NY83

    Protein attributes for MAP7 Gene

    Size:
    749 amino acids
    Molecular mass:
    84052 Da
    Quaternary structure:
    • Interacts with TRPV4.

    Alternative splice isoforms for MAP7 Gene

neXtProt entry for MAP7 Gene

Post-translational modifications for MAP7 Gene

  • The association with microtubules is regulated by phosphorylation during the cell cycle. During interphase only phosphorylated on serine. Phosphorylated on threonine in mitosis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP7 Gene

Domains & Families for MAP7 Gene

Protein Domains for MAP7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q14244

UniProtKB/Swiss-Prot:

MAP7_HUMAN :
  • Belongs to the MAP7 family.
Family:
  • Belongs to the MAP7 family.
genes like me logo Genes that share domains with MAP7: view

No data available for Gene Families for MAP7 Gene

Function for MAP7 Gene

Molecular function for MAP7 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon terminal differentiation of primary keratinocytes.

Gene Ontology (GO) - Molecular Function for MAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding ISS --
GO:0005198 structural molecule activity TAS 8408219
GO:0005515 protein binding IPI 27018634
genes like me logo Genes that share ontologies with MAP7: view
genes like me logo Genes that share phenotypes with MAP7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP7 Gene

Localization for MAP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP7 Gene

Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP7 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for MAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 8408219
genes like me logo Genes that share ontologies with MAP7: view

Pathways & Interactions for MAP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0006970 response to osmotic stress ISS --
GO:0007163 establishment or maintenance of cell polarity TAS 8408219
GO:0072659 protein localization to plasma membrane ISS --
genes like me logo Genes that share ontologies with MAP7: view

No data available for Pathways by source and SIGNOR curated interactions for MAP7 Gene

Drugs & Compounds for MAP7 Gene

(17) Drugs for MAP7 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cabazitaxel Approved Pharma 0
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1967
Griseofulvin Approved, Vet_approved Pharma 6
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 922
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent 0

(16) ApexBio Compounds for MAP7 Gene

Compound Action Cas Number
2-Methoxyestradiol (2-MeOE2) Apoptotic, antiproliferative and antiangiogenic agent 362-07-2
Cabazitaxel 183133-96-2
CK-636 Arp2/3 complex inhibitor 442632-72-6
CYT997 (Lexibulin) 917111-44-5
Docetaxel Microtubulin disassembly inhibitor 114977-28-5
Epothilone A Microtubule stabilizing macrolide 152044-53-6
Epothilone B (EPO906, Patupilone) Microtubule stabilizing macrolide 152044-54-7
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium 168555-66-6
Griseofulvin 126-07-8
INH6 1001753-24-7
MPC 6827 hydrochloride Potent microtubule inhibitor 917369-31-4
Nocodazole Tubulin production inhibitor,anti-neoplastic agent 31430-18-9
Plinabulin (NPI-2358) Tumor cell lines inhibitor 714272-27-2
Vincristine Microtubule disrupter,antitumor agent 2068-78-2
Vinflunine Tartrate 1201898-17-0
Vinorelbine ditartrate Anti-mitotic chemotherapy drug 125317-39-7
genes like me logo Genes that share compounds with MAP7: view

Drug Products

Transcripts for MAP7 Gene

Unigene Clusters for MAP7 Gene

Microtubule-associated protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP7 Gene

No ASD Table

Relevant External Links for MAP7 Gene

GeneLoc Exon Structure for
MAP7
ECgene alternative splicing isoforms for
MAP7

Expression for MAP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP7 Gene

mRNA differential expression in normal tissues according to GTEx for MAP7 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.3).

Protein differential expression in normal tissues from HIPED for MAP7 Gene

This gene is overexpressed in Testis (19.6), Liver (8.7), and Lung (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP7 Gene



Protein tissue co-expression partners for MAP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP7 Gene:

MAP7

SOURCE GeneReport for Unigene cluster for MAP7 Gene:

Hs.486548

mRNA Expression by UniProt/SwissProt for MAP7 Gene:

Q14244-MAP7_HUMAN
Tissue specificity: Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas.

Evidence on tissue expression from TISSUES for MAP7 Gene

  • Nervous system(4.9)
  • Pancreas(4.5)
  • Liver(4.3)
  • Intestine(3)
  • Gall bladder(2.7)
  • Kidney(2.7)
  • Skin(2.7)
  • Stomach(2.7)
genes like me logo Genes that share expression patterns with MAP7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP7 Gene

Orthologs for MAP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP7 34 35
  • 96.41 (n)
dog
(Canis familiaris)
Mammalia MAP7 34 35
  • 87.99 (n)
cow
(Bos Taurus)
Mammalia MAP7 34
  • 86.49 (n)
MGC151537 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map7 34 16 35
  • 81.49 (n)
rat
(Rattus norvegicus)
Mammalia Map7 34
  • 81.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAP7 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP7 34 35
  • 68.4 (n)
lizard
(Anolis carolinensis)
Reptilia MAP7 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497841 34
  • 60.34 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC563520 34
  • 56.23 (n)
MAP7 (1 of 2) 35
  • 44 (a)
OneToMany
MAP7 (2 of 2) 35
  • 33 (a)
OneToMany
Species where no ortholog for MAP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP7 Gene

ENSEMBL:
Gene Tree for MAP7 (if available)
TreeFam:
Gene Tree for MAP7 (if available)

Paralogs for MAP7 Gene

Paralogs for MAP7 Gene

(2) SIMAP similar genes for MAP7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MAP7 Gene

genes like me logo Genes that share paralogs with MAP7: view

Variants for MAP7 Gene

Sequence variations from dbSNP and Humsavar for MAP7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000043877 -- 136,466,784(+) CCATG(C/T)TAAAA intron-variant, utr-variant-5-prime
rs1000077177 -- 136,468,327(+) ACACA(C/T)ATGAA intron-variant, upstream-variant-2KB
rs1000090158 -- 136,367,464(+) GCATC(A/G)ACTCC intron-variant
rs1000097718 -- 136,459,500(+) ATGGA(A/T)ACAAA intron-variant
rs1000101282 -- 136,397,294(+) AAAAG(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP7 Gene

Variant ID Type Subtype PubMed ID
dgv1065n67 CNV loss 20364138
dgv10947n54 CNV loss 21841781
dgv10948n54 CNV loss 21841781
dgv10949n54 CNV loss 21841781
dgv1154e199 CNV deletion 23128226
dgv1221e214 CNV gain 21293372
esv2067162 CNV deletion 18987734
esv24386 CNV loss 19812545
esv2614575 CNV deletion 19546169
esv2665783 CNV deletion 23128226
esv2666931 CNV deletion 23128226
esv2670575 CNV deletion 23128226
esv27134 CNV loss 19812545
esv2732763 CNV deletion 23290073
esv3346290 CNV insertion 20981092
esv3386359 CNV insertion 20981092
esv3540524 CNV deletion 23714750
esv3610917 CNV gain 21293372
esv3610918 CNV loss 21293372
esv3610919 CNV loss 21293372
esv3610921 CNV loss 21293372
esv3610922 CNV gain 21293372
esv3610923 CNV loss 21293372
esv3610924 CNV loss 21293372
esv6777 CNV loss 19470904
nsv464064 CNV loss 19166990
nsv604725 CNV loss 21841781
nsv820004 CNV loss 19587683

Variation tolerance for MAP7 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP7 Gene

Disorders for MAP7 Gene

Relevant External Links for MAP7

Genetic Association Database (GAD)
MAP7
Human Genome Epidemiology (HuGE) Navigator
MAP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP7

No disorders were found for MAP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP7 Gene

Publications for MAP7 Gene

  1. Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells. (PMID: 8408219) Masson D. … Kreis T.E. (J. Cell Biol. 1993) 2 3 4 22 64
  2. Rapid dynamics of the microtubule binding of ensconsin in vivo. (PMID: 11719555) Bulinski J.C. … Waterman-Storer C.M. (J. Cell Sci. 2001) 3 4 22 64
  3. Upregulation and redistribution of E-MAP-115 (epithelial microtubule- associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts. (PMID: 9989799) Fabre-Jonca N. … Masson D. (J. Invest. Dermatol. 1999) 3 4 22 64
  4. Binding of E-MAP-115 to microtubules is regulated by cell cycle- dependent phosphorylation. (PMID: 7490279) Masson D. … Kreis T.E. (J. Cell Biol. 1995) 3 4 22 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for MAP7 Gene

  • Addgene plasmids for MAP7

Sources for MAP7 Gene

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