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MAP7 Gene

protein-coding   GIFtS: 54
GCID: GC06M136663

Microtubule-Associated Protein 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule-Associated Protein 71 2 3     EMAP1152 5
Epithelial Microtubule-Associated Protein Of 115 KDa2 3     DJ325F22.2 (Microtubule-Associated Protein 7 (EMAP115, E-MAP-115))2
E-MAP-1152 3     ensconsin2
MAP-72 3     

External Ids:    HGNC: 68691   Entrez Gene: 90532   Ensembl: ENSG000001355257   OMIM: 6041085   UniProtKB: Q142443   

Export aliases for MAP7 gene to outside databases

Previous GC identifers: GC06M136287 GC06M136510 GC06M136599 GC06M136644 GC06M136645 GC06M136705 GC06M134228


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP7 Gene:
The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of
epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is
essential for cell polarization and differentiation. This protein has been shown to be able to stabilize
microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also
suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2010)

GeneCards Summary for MAP7 Gene:
MAP7 (microtubule-associated protein 7) is a protein-coding gene. Diseases associated with MAP7 include barrett's adenocarcinoma, and basal cell carcinoma. GO annotations related to this gene include structural molecule activity and receptor binding. An important paralog of this gene is MAP7D2.

UniProtKB/Swiss-Prot: MAP7_HUMAN, Q14244
Function: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules
during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner.
May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the
redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments

Gene Wiki entry for MAP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP7 gene promoter:
         AhR   AML1a   Olf-1   GATA-1   Arnt   RORalpha1   POU2F1   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP7 promoter sequence
   Search Chromatin IP Primers for MAP7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.3   Ensembl cytogenetic band:  6q23.3   HGNC cytogenetic band: 6q23.2

MAP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M136663:  view genomic region     (about GC identifiers)

Start:
136,663,419 bp from pter      End:
136,871,957 bp from pter
Size:
208,539 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAP7_HUMAN, Q14244 (See protein sequence)
Recommended Name: Ensconsin  
Size: 749 amino acids; 84052 Da
Subunit: Interacts with TRPV4 (By similarity)
Secondary accessions: B7Z290 B7Z400 B7Z5S7 B7Z9U7 C9JPS0 E9PCP3 F5H1E2 Q7Z6S0 Q8TAU5 Q9NY82
Q9NY83
Alternative splicing: 7 isoforms:  Q14244-1   Q14244-2   Q14244-3   Q14244-4   Q14244-5   Q14244-6   Q14244-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP7: NX_Q14244

Explore proteomics data for MAP7 at MOPED

Post-translational modifications: 

  • The association with microtubules is regulated by phosphorylation during the cell cycle. During interphase only
    phosphorylated on serine. Phosphorylated on threonine in mitosis1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAP7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001185537.1  NP_001185538.1  NP_001185540.1  NP_001185543.1  NP_001185544.1  NP_001185545.1  NP_001185546.1  NP_001185547.1  
    NP_001185548.1  NP_003971.1  

    ENSEMBL proteins: 
     ENSP00000346581   ENSP00000414712   ENSP00000400790   ENSP00000445737   ENSP00000414879  

    MAP7 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MAP7
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    Novus Biologicals MAP7 Lysates
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    Cloud-Clone Corp. Proteins for MAP7

    MAP7 Antibody Products:

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    Abcam antibodies for MAP7
    Cloud-Clone Corp. Antibodies for MAP7
    ThermoFisher Antibodies for MAP7
    LSBio Antibodies in human, mouse, rat for MAP7

    MAP7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MAP7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP7
    Cloud-Clone Corp. CLIAs for MAP7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008604 MAP7

    Graphical View of Domain Structure for InterPro Entry Q14244

    ProtoNet protein and cluster: Q14244

    UniProtKB/Swiss-Prot: MAP7_HUMAN, Q14244
    Similarity: Belongs to the MAP7 family


    MAP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAP7_HUMAN, Q14244
    Function: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules
    during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner.
    May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the
    redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments
    Induction: Up-regulated upon terminal differentiation of primary keratinocytes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ISS--
    GO:0005198structural molecule activity TAS8408219
    GO:0005515protein binding ----
         
    MAP7 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Map7):
     endocrine/exocrine gland  immune system  reproductive system 

    MAP7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP7

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP7:
    hsa-mir-93-5p (MIRT028046), hsa-let-7b-5p (MIRT032292), hsa-mir-16-5p (MIRT031639), hsa-mir-19b-3p (MIRT031147), hsa-mir-130b-3p (MIRT020192)

    Block miRNA regulation of human, mouse, rat MAP7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP7 (see all 57):
    hsa-miR-549 hsa-miR-323-3p hsa-miR-106a hsa-miR-15a hsa-miR-218-1* hsa-miR-301a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidMAP7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP7
    Predesigned siRNA for gene silencing in human, mouse, rat MAP7

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MAP7

    Clone
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    OriGene clones in human, mouse for MAP7 (see all 25)
    OriGene ORF clones in mouse, rat for MAP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 10): MAP7 (NM_003980)
    Sino Biological Human cDNA Clone for MAP7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP7

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAP7
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP7 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAP7_HUMAN, Q14244: Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton.
    Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte
    terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in
    spike-like bundles facing intercellular contacts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex TAS8408219
    GO:0005886plasma membrane ----
    GO:0015630microtubule cytoskeleton IDA--

    MAP7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAP7
    Interactions:

        GeneGlobe Interaction Network for MAP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MAP7 (Q142442, 3 ENSP000003465814) via UniProtKB, MINT, STRING, and/or I2D (see all 561)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRPV4Q9HBA03, ENSP000002617404I2D: score=2 STRING: ENSP00000261740
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    DVL2O146413I2D: score=1 
    DVL3Q929973I2D: score=1 
    PCBD1P614573I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization TAS8408219
    GO:0000902cell morphogenesis IEA--
    GO:0001578microtubule bundle formation IEA--
    GO:0006687glycosphingolipid metabolic process IEA--
    GO:0006970response to osmotic stress ISS--

    MAP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    9 ApexBio Compounds for MAP7     About this table
    CompoundAction CAS #
    7-xylosyltaxoltaxol (Paclitaxel) derivative[90332-66-4]
    ColchicineColchicine, a tubulin Inhibitor[64-86-8]
    D-64131novel inhibitor of Tubulin polymerization[74588-78-6]
    Docetaxel Trihydrateinhibitor of depolymerisation of microtubules[148408-66-6]
    Mc-MMADPotent tubulin inhibitor[1401963-15-2]
    MMADPotent tubulin inhibitor[203849-91-6]
    Monomethyl auristatin EAntimitotic agent[474645-27-7]
    PodophyllotoxinActions Inhibits microtubule assembly[518-28-5]
    Vc-MMADantibody drug conjugate[1401963-17-4]

    Browse Tocris compounds for MAP7

    1 Novoseek inferred chemical compound relationship for MAP7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paclitaxel 36.7 3 11668581 (2)



    MAP7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAP7 gene (10 alternative transcripts): 
    NM_001198608.1  NM_001198609.1  NM_001198611.1  NM_001198614.1  NM_001198615.1  NM_001198616.1  NM_001198617.1  NM_001198618.1  
    NM_001198619.1  NM_003980.4  

    Unigene Cluster for MAP7:

    Microtubule-associated protein 7
    Hs.486548  [show with all ESTs]
    Unigene Representative Sequence: NM_003980
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354570(uc011edf.2 uc010kgu.3 uc011edg.2 uc011edh.2 uc010kgv.3 uc010kgs.3 uc011edi.2 uc010kgq.2 uc003qgz.3 uc003qha.2)
    ENST00000454590(uc010kgt.2) ENST00000438100 ENST00000544465 ENST00000432797(uc010kgr.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAP7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP7 (see all 57):
    hsa-miR-549 hsa-miR-323-3p hsa-miR-106a hsa-miR-15a hsa-miR-218-1* hsa-miR-301a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidMAP7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAP7
    Predesigned siRNA for gene silencing in human, mouse, rat MAP7
    Clone
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    OriGene clones in human, mouse for MAP7 (see all 25)
    OriGene ORF clones in mouse, rat for MAP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 10): MAP7 (NM_003980)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAP7
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP7
      QuantiTect SYBR Green Assays in human, mouse, rat MAP7
      QuantiFast Probe-based Assays in human, mouse, rat MAP7

    Additional mRNA sequence: 

    AJ242501.1 AJ242502.1 AJ420541.1 AK294461.1 AK295749.1 AK296483.1 AK296556.1 AK299355.1 
    AK307873.1 AK311114.1 AK311227.1 AK311234.1 AK311236.1 AK311270.1 AK312789.1 AK316062.1 
    AK316529.1 BC025777.1 X73882.1 

    14 DOTS entries:

    DT.97841077  DT.100770276  DT.100770312  DT.317008  DT.95240153  DT.86858952  DT.99994863  DT.121372310 
    DT.86849853  DT.91951779  DT.101960650  DT.121372306  DT.40114616  DT.97815835 

    Selected AceView cDNA sequences (see all 156):

    AA594684 BM672895 AJ242501 BM840395 BX098491 AW263065 BQ029455 AA939180 
    BX499461 NM_003980 AW444516 CB151084 AL698924 AI924310 BF063418 CB158648 
    BG656248 AI439098 AA470051 AJ242502 BE219849 AI565221 AA488545 AA701579 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACACCAAA
    MAP7 Expression
    About this image


    MAP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Mature Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
    MAP7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.486548

    UniProtKB/Swiss-Prot: MAP7_HUMAN, Q14244
    Tissue specificity: Expressed in the skin and cells of epithelial origin. Predominantly expressed in the
    suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely
    detectable in basal cell carcinomas

        Custom PCR Arrays for MAP7
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAP7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP7
    QuantiTect SYBR Green Assays in human, mouse, rat MAP7
    QuantiFast Probe-based Assays in human, mouse, rat MAP7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MAP7 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map71 , 5 microtubule-associated protein 71, 5 81.49(n)1
    79.78(a)1
      10 (9.75 cM)5
    177611  NM_001198635.11  NP_001185564.11 
     201489205 
    chicken
    (Gallus gallus)
    Aves MAP71 microtubule-associated protein 7 68.4(n)
    67.05(a)
      421689  NM_001031072.1  NP_001026243.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAP76
    microtubule-associated protein 7
    61(a)
    1 ↔ 1
    GL343200.1(2340285-2457223)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004978411 ensconsin-like 60.34(n)
    53.6(a)
      100497841  XM_004914651.1  XP_004914708.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ074316.12   -- 82.08(n)    BQ074316.1 


    ENSEMBL Gene Tree for MAP7 (if available)
    TreeFam Gene Tree for MAP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP7 gene
    MAP7D22  MAP7D32  MAP7D12  
    2 SIMAP similar genes for MAP7 using alignment to 1 protein entry:     MAP7_HUMAN:
    RPRC1    MAP7D1

    MAP7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MAP7
    PGOHUM00000235098 PGOHUM00000243985


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP7 (see all 3765)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127328831,2
    C,F--136663005(+) TTATAG/ATATCT 10 -- ds50012Minor allele frequency- A:0.04CSA WA 120
    rs20380821,2
    C,F,A,H--136663008(+) TAGTAC/TCTCAG 10 -- ds500132Minor allele frequency- T:0.16NA EA NS WA CSA 3848
    rs1833536281,2
    --136663027(+) ATCTCC/TTTGCC 10 -- ds50010--------
    rs2014007561,2
    C--136663032(+) CTTGCC/TCCTGT 10 -- ds50010--------
    rs1878352461,2
    --136663066(+) ACACGC/TTTATG 10 -- ds50010--------
    rs1911519961,2
    C--136663178(+) GGTTAC/TTTAGG 10 -- ds50010--------
    rs1409011821,2
    C--136663241(+) TTGTCA/GTATAG 10 -- ds50010--------
    rs1501341501,2
    C--136663304(+) ATGTAA/GGAGGA 10 -- ds50010--------
    rs1824728831,2
    --136663509(+) TTAAGC/GTCTGC 10 -- ut310--------
    rs1879330901,2
    --136663527(+) TATAGA/TTTTTT 10 -- ut310--------

    HapMap Linkage Disequilibrium report for MAP7 (136663419 - 136871957 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAP7 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666931CNV Deletion23128226
    esv2665783CNV Deletion23128226
    esv2067162CNV Deletion18987734
    esv2732763CNV Deletion23290073
    esv2670575CNV Deletion23128226
    esv2614575CNV Deletion19546169
    dgv1154e199CNV Deletion23128226
    nsv820004CNV Loss19587683
    nsv464064CNV Loss19166990
    esv6777CNV Loss19470904

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604108    OMIM disorders: --

    12 diseases for MAP7:    
    About MalaCards
    barrett's adenocarcinoma    basal cell carcinoma    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    squamous cell carcinoma    adenocarcinoma    tonsillitis    thyroiditis
    cerebritis    endotheliitis    malaria    prostatitis


    MAP7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAP7
    Human Genome Epidemiology (HuGE) Navigator: MAP7 (4 documents)

    Export disorders for MAP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP7 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with MAP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells. (PubMed id 8408219)1, 2, 3, 9 Masson D. and Kreis T.E. (J. Cell Biol. 1993)
    2. Binding of E-MAP-115 to microtubules is regulated by cell cycle- dependent phosphorylation. (PubMed id 7490279)1, 2, 9 Masson D. and Kreis T.E. (J. Cell Biol. 1995)
    3. Upregulation and redistribution of E-MAP-115 (epithelial microtubule- associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts. (PubMed id 9989799)1, 2, 9 Fabre-Jonca N.... Masson D. (J. Invest. Dermatol. 1999)
    4. Rapid dynamics of the microtubule binding of ensconsin in vivo. (PubMed id 11719555)1, 2, 9 Bulinski J.C....Waterman-Storer C.M. (J. Cell Sci. 2001)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. Expression and distribution of distinct variants of E-MAP-115 during proliferation and differentiation of human intestinal epithelial cells. (PubMed id 12845596)1, 9 Vanier M.T....Launay J.F. (Cell Motil. Cytoskeleton 2003)
    10. The expression ratio of Map7/B2M is prognostic for survival in patients with stage II colon cancer. (PubMed id 18695889)1, 9 Blum C....Mitas M. (Int. J. Oncol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9053 HGNC: 6869 AceView: MAP7 Ensembl:ENSG00000135525 euGenes: HUgn9053
    ECgene: MAP7 H-InvDB: MAP7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAP7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MAP7 gene:
    Search GeneIP for patents involving MAP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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