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Aliases for MAP6D1 Gene

Aliases for MAP6D1 Gene

  • MAP6 Domain Containing 1 2 3 5
  • 21 KDa STOP-Like Protein 3 4
  • STOP-Like Protein 21 KD 2 3
  • SL21 3 4
  • MAP6 Domain-Containing Protein 1 3
  • MAPO6D1 3

External Ids for MAP6D1 Gene

Previous GeneCards Identifiers for MAP6D1 Gene

  • GC03M185017
  • GC03M183533
  • GC03M180943

Summaries for MAP6D1 Gene

Entrez Gene Summary for MAP6D1 Gene

  • This gene encodes a protein highly similar to the mouse MAP6 domain containing 1 protein, which is related to the STOP proteins. Based on the study of the mouse protein, the encoded protein may function as a calmodulin-regulated neuronal protein that binds and stabilizes microtubules but also associates with the Golgi membranes through N-terminal palmitoylation. [provided by RefSeq, Oct 2008]

GeneCards Summary for MAP6D1 Gene

MAP6D1 (MAP6 Domain Containing 1) is a Protein Coding gene. Diseases associated with MAP6D1 include Autonomic Nervous System Disease. GO annotations related to this gene include microtubule binding and calmodulin binding. An important paralog of this gene is MAP6.

UniProtKB/Swiss-Prot for MAP6D1 Gene

  • May have microtubule-stabilizing activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP6D1 Gene

Genomics for MAP6D1 Gene

Regulatory Elements for MAP6D1 Gene

Enhancers for MAP6D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F183797 0.2 ENCODE 18.7 +26.3 26337 4.1 HDAC1 HDGF PKNOX1 YBX1 ZBTB40 ZNF766 GATA2 SCRT2 ETV6 CREM YEATS2-AS1 MAP6D1 YEATS2 GC03M183803
GH03F183822 0.4 FANTOM5 17.8 +2.7 2749 0.1 HDGF TEAD4 JUNB TRIM22 BMI1 JUND IKZF1 EED ZBTB33 CREM MAP6D1 MCF2L2 ECE2 CAMK2N2 ABCC5 YEATS2-AS1
GH03F183876 0.9 Ensembl ENCODE 10.3 -52.5 -52512 2.6 HDAC1 MAX CEBPB GABPA ARID1B IKZF1 HMBOX1 ZBTB33 KDM1A MYC PARL ABCC5 MAP6D1 ALG3 ECE2 VWA5B2 MIR1224 CAMK2N2 EIF2B5 FAM131A
GH03F183880 1.1 Ensembl 10.3 -54.8 -54796 0.8 ZNF280D TRIM24 PARL ABCC5 MAP6D1 ALG3 ECE2 VWA5B2 MIR1224 CAMK2N2 EIF2B5 FAM131A
GH03F183881 0.9 Ensembl 10.3 -55.5 -55496 0.2 HLF ABCC5 MAP6D1 ALG3 ECE2 VWA5B2 MIR1224 CAMK2N2 EIF2B5 FAM131A EIF4G1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MAP6D1 on UCSC Golden Path with GeneCards custom track

Promoters for MAP6D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001381193 405 2001 SIN3A RAD21 GLIS2 ZNF366 EGR2 ZNF654 ZNF680 SP3 ZNF592 NR2F2

Genomic Location for MAP6D1 Gene

Chromosome:
3
Start:
183,815,876 bp from pter
End:
183,825,605 bp from pter
Size:
9,730 bases
Orientation:
Minus strand

Genomic View for MAP6D1 Gene

Genes around MAP6D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP6D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP6D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP6D1 Gene

Proteins for MAP6D1 Gene

  • Protein details for MAP6D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9H5-MA6D1_HUMAN
    Recommended name:
    MAP6 domain-containing protein 1
    Protein Accession:
    Q9H9H5

    Protein attributes for MAP6D1 Gene

    Size:
    199 amino acids
    Molecular mass:
    21005 Da
    Quaternary structure:
    • Interacts with calmodulin.

neXtProt entry for MAP6D1 Gene

Post-translational modifications for MAP6D1 Gene

  • Palmitoylated. Palmitoylation enhances association with microtubules.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP6D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP6D1 Gene

Domains & Families for MAP6D1 Gene

Protein Domains for MAP6D1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP6D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9H5

UniProtKB/Swiss-Prot:

MA6D1_HUMAN :
  • Belongs to the STOP family.
Family:
  • Belongs to the STOP family.
genes like me logo Genes that share domains with MAP6D1: view

No data available for Gene Families for MAP6D1 Gene

Function for MAP6D1 Gene

Molecular function for MAP6D1 Gene

UniProtKB/Swiss-Prot Function:
May have microtubule-stabilizing activity.

Gene Ontology (GO) - Molecular Function for MAP6D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IEA --
GO:0008017 microtubule binding IEA,IBA --
genes like me logo Genes that share ontologies with MAP6D1: view
genes like me logo Genes that share phenotypes with MAP6D1: view

Animal Model Products

miRNA for MAP6D1 Gene

miRTarBase miRNAs that target MAP6D1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP6D1 Gene

Localization for MAP6D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP6D1 Gene

Golgi apparatus. Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP6D1 Gene COMPARTMENTS Subcellular localization image for MAP6D1 gene
Compartment Confidence
mitochondrion 3
cytoskeleton 2
cytosol 2
golgi apparatus 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MAP6D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005798 Golgi-associated vesicle IEA,IBA --
GO:0005801 cis-Golgi network IEA,IBA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with MAP6D1: view

Pathways & Interactions for MAP6D1 Gene

SuperPathways for MAP6D1 Gene

No Data Available

Interacting Proteins for MAP6D1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000314560%0d%0a9606.ENSP00000272298%0d%0a
Selected Interacting proteins: ENSP00000314560 Q9H9H5-MA6D1_HUMAN for MAP6D1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MAP6D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0007026 negative regulation of microtubule depolymerization IEA --
GO:0018009 N-terminal peptidyl-L-cysteine N-palmitoylation IEA --
genes like me logo Genes that share ontologies with MAP6D1: view

No data available for Pathways by source and SIGNOR curated interactions for MAP6D1 Gene

Transcripts for MAP6D1 Gene

mRNA/cDNA for MAP6D1 Gene

Unigene Clusters for MAP6D1 Gene

MAP6 domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP6D1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -

Relevant External Links for MAP6D1 Gene

GeneLoc Exon Structure for
MAP6D1
ECgene alternative splicing isoforms for
MAP6D1

Expression for MAP6D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP6D1 Gene

mRNA differential expression in normal tissues according to GTEx for MAP6D1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.0), Brain - Cerebellum (x5.8), Brain - Cerebellar Hemisphere (x5.7), and Brain - Substantia nigra (x4.6).

Protein differential expression in normal tissues from HIPED for MAP6D1 Gene

This gene is overexpressed in Frontal cortex (42.4) and Brain (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP6D1 Gene



Protein tissue co-expression partners for MAP6D1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP6D1 Gene:

MAP6D1

SOURCE GeneReport for Unigene cluster for MAP6D1 Gene:

Hs.478465
genes like me logo Genes that share expression patterns with MAP6D1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAP6D1 Gene

Orthologs for MAP6D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP6D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP6D1 34 35
  • 99.16 (n)
cow
(Bos Taurus)
Mammalia MAP6D1 34 35
  • 85.59 (n)
mouse
(Mus musculus)
Mammalia Map6d1 34 16 35
  • 82.55 (n)
rat
(Rattus norvegicus)
Mammalia Map6d1 34
  • 81.5 (n)
dog
(Canis familiaris)
Mammalia MAP6D1 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP6D1 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP6D1 35
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii map6d1 35
  • 26 (a)
OneToOne
Species where no ortholog for MAP6D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP6D1 Gene

ENSEMBL:
Gene Tree for MAP6D1 (if available)
TreeFam:
Gene Tree for MAP6D1 (if available)

Paralogs for MAP6D1 Gene

Paralogs for MAP6D1 Gene

genes like me logo Genes that share paralogs with MAP6D1: view

Variants for MAP6D1 Gene

Sequence variations from dbSNP and Humsavar for MAP6D1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10428166 -- 183,819,258(+) GAGCT(A/G)GGCCG intron-variant
rs10428248 -- 183,818,875(+) AGGGA(C/G)AGGAT intron-variant
rs1061593 -- 183,816,750(-) GCCTC(A/G)TGTTT nc-transcript-variant, utr-variant-3-prime
rs1061594 -- 183,816,382(-) CACAC(A/G)TTTGA nc-transcript-variant, utr-variant-3-prime
rs111272334 -- 183,819,791(+) CTGAA(A/G)AGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP6D1 Gene

Variant ID Type Subtype PubMed ID
dgv8757n54 CNV gain 21841781
dgv8758n54 CNV gain+loss 21841781
esv24115 CNV loss 19812545
nsv524639 CNV loss 19592680
nsv592656 CNV gain 21841781
nsv592659 CNV loss 21841781
nsv592660 CNV gain+loss 21841781
nsv592663 CNV loss 21841781
nsv592664 CNV gain 21841781

Variation tolerance for MAP6D1 Gene

Gene Damage Index Score: 1.31; 26.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP6D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP6D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP6D1 Gene

Disorders for MAP6D1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP6D1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
autonomic nervous system disease
  • autonomic nervous system disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAP6D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP6D1
genes like me logo Genes that share disorders with MAP6D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP6D1 Gene

Publications for MAP6D1 Gene

  1. Non-microtubular localizations of microtubule-associated protein 6 (MAP6). (PMID: 25526643) Gory-FaurAc S. … Andrieux A. (PLoS ONE 2014) 2 3 64
  2. STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins. (PMID: 16837464) Gory-Faure S. … Andrieux A. (J. Biol. Chem. 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for MAP6D1 Gene

Sources for MAP6D1 Gene

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