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Aliases for MAP6D1 Gene

Aliases for MAP6D1 Gene

  • MAP6 Domain Containing 1 2 3
  • SL21 3 4 6
  • 21 KDa STOP-Like Protein 3 4
  • STOP-Like Protein 21 KD 2 3
  • MAPO6D1 3 6
  • MAP6 Domain-Containing Protein 1 3

External Ids for MAP6D1 Gene

Summaries for MAP6D1 Gene

Entrez Gene Summary for MAP6D1 Gene

  • This gene encodes a protein highly similar to the mouse MAP6 domain containing 1 protein, which is related to the STOP proteins. Based on the study of the mouse protein, the encoded protein may function as a calmodulin-regulated neuronal protein that binds and stabilizes microtubules but also associates with the Golgi membranes through N-terminal palmitoylation. [provided by RefSeq, Oct 2008]

GeneCards Summary for MAP6D1 Gene

MAP6D1 (MAP6 Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include calmodulin binding and microtubule binding. An important paralog of this gene is MAP6.

UniProtKB/Swiss-Prot for MAP6D1 Gene

  • May have microtubule-stabilizing activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP6D1 Gene

Genomics for MAP6D1 Gene

Genomic Location for MAP6D1 Gene

Start:
183,815,876 bp from pter
End:
183,825,605 bp from pter
Size:
9,730 bases
Orientation:
Minus strand

Genomic View for MAP6D1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP6D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP6D1 Gene

Regulatory Elements for MAP6D1 Gene

Proteins for MAP6D1 Gene

  • Protein details for MAP6D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9H5-MA6D1_HUMAN
    Recommended name:
    MAP6 domain-containing protein 1
    Protein Accession:
    Q9H9H5
    Secondary Accessions:

    Protein attributes for MAP6D1 Gene

    Size:
    199 amino acids
    Molecular mass:
    21005 Da
    Quaternary structure:
    • Interacts with calmodulin.

neXtProt entry for MAP6D1 Gene

Proteomics data for MAP6D1 Gene at MOPED

Post-translational modifications for MAP6D1 Gene

  • Palmitoylated. Palmitoylation enhances association with microtubules.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP6D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP6D1 Gene

Domains for MAP6D1 Gene

Protein Domains for MAP6D1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP6D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9H5

UniProtKB/Swiss-Prot:

MA6D1_HUMAN
Family:
  • Belongs to the STOP family.:
    • Q9H9H5
genes like me logo Genes that share domains with MAP6D1: view

No data available for Gene Families for MAP6D1 Gene

Function for MAP6D1 Gene

Molecular function for MAP6D1 Gene

UniProtKB/Swiss-Prot Function: May have microtubule-stabilizing activity.

Gene Ontology (GO) - Molecular Function for MAP6D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with MAP6D1: view

Phenotypes for MAP6D1 Gene

GenomeRNAi human phenotypes for MAP6D1:
genes like me logo Genes that share phenotypes with MAP6D1: view

miRNA for MAP6D1 Gene

miRTarBase miRNAs that target MAP6D1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAP6D1 Gene

Localization for MAP6D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP6D1 Gene

Golgi apparatus. Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP6D1 Gene COMPARTMENTS Subcellular localization image for MAP6D1 gene
Compartment Confidence
golgi apparatus 5
mitochondrion 3
cytoskeleton 2
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MAP6D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005798 Golgi-associated vesicle IEA --
GO:0005801 cis-Golgi network IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with MAP6D1: view

Pathways for MAP6D1 Gene

SuperPathways for MAP6D1 Gene

No Data Available

Interacting Proteins for MAP6D1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000314560%0d%0a9606.ENSP00000272298%0d%0a
Selected Interacting proteins: ENSP00000314560 for MAP6D1 Gene via STRING

Symbol External ID(s) Details
CALM2

Gene Ontology (GO) - Biological Process for MAP6D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0007026 negative regulation of microtubule depolymerization IEA --
GO:0018009 N-terminal peptidyl-L-cysteine N-palmitoylation IEA --
GO:0032418 lysosome localization IEA --
GO:0048813 dendrite morphogenesis IEA --
genes like me logo Genes that share ontologies with MAP6D1: view

No data available for Pathways by source for MAP6D1 Gene

Transcripts for MAP6D1 Gene

mRNA/cDNA for MAP6D1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(90) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP6D1 Gene

MAP6 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP6D1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -

Relevant External Links for MAP6D1 Gene

GeneLoc Exon Structure for
MAP6D1
ECgene alternative splicing isoforms for
MAP6D1

Expression for MAP6D1 Gene

mRNA expression in normal human tissues for MAP6D1 Gene

mRNA differential expression in normal tissues according to GTEx for MAP6D1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (8.0), Brain - Cerebellum (5.8), Brain - Cerebellar Hemisphere (5.7), and Brain - Substantia nigra (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAP6D1 Gene

SOURCE GeneReport for Unigene cluster for MAP6D1 Gene Hs.478465

genes like me logo Genes that share expressions with MAP6D1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAP6D1 Gene

Orthologs for MAP6D1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP6D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP6D1 35
  • 99.16 (n)
  • 97.99 (a)
MAP6D1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP6D1 35
  • 85.59 (n)
  • 83.33 (a)
MAP6D1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP6D1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map6d1 35
  • 82.55 (n)
  • 75.92 (a)
Map6d1 16
Map6d1 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP6D1 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map6d1 35
  • 81.5 (n)
  • 74.87 (a)
lizard
(Anolis carolinensis)
Reptilia MAP6D1 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii map6d1 36
  • 26 (a)
OneToOne
Species with no ortholog for MAP6D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP6D1 Gene

ENSEMBL:
Gene Tree for MAP6D1 (if available)
TreeFam:
Gene Tree for MAP6D1 (if available)

Paralogs for MAP6D1 Gene

Paralogs for MAP6D1 Gene

genes like me logo Genes that share paralogs with MAP6D1: view

Variants for MAP6D1 Gene

Sequence variations from dbSNP and Humsavar for MAP6D1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8391 -- 183,816,176(-) CTCCG(A/C/G/T)CTGCC utr-variant-3-prime
rs894000 -- 183,818,275(-) AGTGC(A/G)CTTGC intron-variant
rs897604 -- 183,817,975(+) CTGCT(A/G)CACCA intron-variant
rs1061593 -- 183,816,750(-) GCCTC(A/G)TGTTT utr-variant-3-prime
rs1061594 -- 183,816,382(-) CACAC(A/G)TTTGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAP6D1 Gene

Variant ID Type Subtype PubMed ID
nsv524639 CNV Loss 19592680
esv24115 CNV Loss 19812545

Relevant External Links for MAP6D1 Gene

HapMap Linkage Disequilibrium report
MAP6D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP6D1 Gene

Disorders for MAP6D1 Gene

(1) University of Copenhagen DISEASES for MAP6D1 Gene

genes like me logo Genes that share disorders with MAP6D1: view

No data available for UniProtKB/Swiss-Prot for MAP6D1 Gene

Publications for MAP6D1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins. (PMID: 16837464) Gory-Faure S. … Andrieux A. (J. Biol. Chem. 2006) 3 4
  4. Non-microtubular localizations of microtubule-associated protein 6 (MAP6). (PMID: 25526643) Gory-FaurAc S. … Andrieux A. (PLoS ONE 2014) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MAP6D1 Gene

Sources for MAP6D1 Gene

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