MAP6D1 Gene
protein-coding GIFtS: 45
GCID: GC03M183533
|
|
MAP6 domain containing 1
| |
Aliases
for MAP6D1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MAP6 Domain Containing 11 2 | | FLJ127481 | | SL212 3 5 | | MAP6 Domain-Containing Protein 12 | | 21 KDa STOP-Like Protein2 3 | | STOP-Like Protein 212 | | MAPO6D12 5 | | |
Export aliases for MAP6D1 gene to outside databasesPrevious GC identifers: GC03M185017 GC03M180943 |
Summaries
for MAP6D1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAP6D1:
This gene encodes a protein highly similar to the mouse MAP6 domain containing 1 protein, which is related to the STOPproteins. Based on the study of the mouse protein, the encoded protein may function as a calmodulin-regulated neuronalprotein that binds and stabilizes microtubules but also associates with the Golgi membranes through N-terminalpalmitoylation. (provided by RefSeq, Oct 2008)
UniProtKB/Swiss-Prot: MA6D1_HUMAN, Q9H9H5Function: May have microtubule-stabilizing activity (By similarity)
|
Genomic Views
for MAP6D1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP6D1 gene promoter:
C/EBPbeta Tal-1 RREB-1 GCNF MyoD CUTL1 E47 GCNF-1 ZID GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP6D1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP6D1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q27.1 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27.1MAP6D1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M183533: view genomic region
(about GC identifiers)
Start:
|
183,533,664 bp from pter |
End:
|
183,543,393 bp from pter |
Size:
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9,730 bases |
Orientation:
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minus strand |
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Proteins
for MAP6D1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MA6D1_HUMAN, Q9H9H5 (See
protein sequence)Recommended Name: MAP6 domain-containing protein 1 Size: 199 amino acids; 21005 Da
Subunit: Interacts with calmodulin (By similarity)
Subcellular location: Golgi apparatus. Cytoplasm, cytoskeleton (By similarity). Note=Colocalizes with microtubules (Bysimilarity)Explore the universe of human proteins at neXtProt for MAP6D1: NX_Q9H9H5
Post-translational modifications:
Palmitoylated. Palmitoylation enhances association with microtubules1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H9H5
MAP6D1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079147.1
ENSEMBL proteins: ENSP00000314560 ENSP00000388945 ENSP00000390816
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MAP6D1 for ontologies About GeneDecksing
MAP6D1 Antibody Products:
Assay Products for MAP6D1: |
Protein
Domains /
Families
for MAP6D1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP6D1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H9H5ProtoNet protein and cluster: Q9H9H5 UniProtKB/Swiss-Prot: MA6D1_HUMAN, Q9H9H5Similarity: Belongs to the STOP family |
Function
for MAP6D1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MA6D1_HUMAN, Q9H9H5Function: May have microtubule-stabilizing activity (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6D1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6D1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP6D1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005516 | calmodulin binding |
IEA | -- | | GO:0008017 | microtubule binding |
IEA | -- |
MAP6D1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MAP6D1:
|
Pathways & Interactions
for MAP6D1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAP6D1
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007026 | negative regulation of microtubule depolymerization |
IEA | -- | | GO:0018009 | N-terminal peptidyl-L-cysteine N-palmitoylation |
IEA | -- |
MAP6D1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAP6D1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAP6D1
Search CenterWatch for drugs/clinical trials and news about MAP6D1 / MA6D1
|
Transcripts
for MAP6D1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAP6D1 gene: NM_024871.2 Unigene Cluster for MAP6D1: MAP6 domain containing 1 Hs.478465 [show with all ESTs]Unigene Representative Sequence: NM_0248714 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000318631(uc003fmc.2) ENST00000431348 ENST00000445426 ENST00000463801
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6D1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6D1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAP6D1 (NM_024871) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP6D1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP6D1 |
Additional cDNA sequence: AK022810.1 BC006434.1 5 DOTS entries: DT.215138 DT.100743391 DT.40200196 DT.215139 DT.91783618 24/90 AceView cDNA sequences (see all 90): AI884794 AA329195 AK022810 AI624891 F07090 AA348507 Z46100 AI336362 Z41020 T31037 BG912296 AA890498 BC006434 NM_024871 AI672853 AI498763 AW135982 BG703970 BG707584 AI598154 AW628624 H05075 AI160245 AI879543
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MAP6D1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d |
|---|
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| SP1: | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAP6D1
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Expression
for MAP6D1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAP6D1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGATTTTT
About this image
See MAP6D1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP6D1
SOURCE GeneReport for Unigene cluster: Hs.478465
SABiosciences Custom PCR Arrays for MAP6D1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP6D1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP6D1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP6D1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP6D1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP6D1 |
Orthologs
for MAP6D1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MAP6D1 gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for MAP6D1 (if available)
TreeFam Gene Tree for MAP6D1 (if available) |
Paralogs
for MAP6D1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAP6D1 gene
- MAP62
MAP6D1 for paralogs About GeneDecksing
|
Genomic Variants
for MAP6D1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAP6D1 (183533664 - 183543393 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAP6D1
1 Indel: 68513 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP6D1 |
|
Disorders
/ Diseases
for MAP6D1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAP6D1 for disorders About GeneDecksing
OMIM gene information: 610593
OMIM disorders: --
3  diseases for MAP6D1: About MalaCardsautonomic neuropathy neuropathy neuronitis
1 disease from the University of Copenhagen DISEASES database for MAP6D1:Autonomic neuropathy Export disorders for MAP6D1 gene to outside databases
|
Publications
for MAP6D1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAP6D1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAP6D1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins. (PubMed id 16837464)1, 2 Gory-Faure S.... Andrieux A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MAP6D1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAP6D1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAP6D1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAP6D1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAP6D1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MAP6D1 gene:
Search GeneIP for patents involving MAP6D1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAP6D1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MAP6D1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP6D1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP6D1 | | | OriGene Protein Over-expression Lysate for MAP6D1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAP6D1 | | OriGene 3'-UTR Clone for MAP6D1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6D1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6D1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP6D1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP6D1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP6D1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP6D1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP6D1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP6D1 |
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| | | | Search Tocris compounds for MAP6D1 |
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 | | | MAP6D1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP6D1 |
|  |  |  | | | | ThermoFisher Antibodies for MAP6D1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP6D1 |
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