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Aliases for MAP6 Gene

Aliases for MAP6 Gene

  • Microtubule-Associated Protein 6 2 3
  • Stable Tubule-Only Polypeptide 3 4
  • MAP-6 3 4
  • STOP 3 4
  • CTD-2530H12.7 3
  • KIAA1878 4
  • MAP6-N 3
  • N-STOP 3
  • MTAP6 3

External Ids for MAP6 Gene

Previous GeneCards Identifiers for MAP6 Gene

  • GC06U990078
  • GC11U900013
  • GC11M075536
  • GC11M075040
  • GC11M075024
  • GC11M074975
  • GC11M075297
  • GC11M071595

Summaries for MAP6 Gene

Entrez Gene Summary for MAP6 Gene

  • This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP6 Gene

MAP6 (Microtubule-Associated Protein 6) is a Protein Coding gene. Diseases associated with MAP6 include ebstein anomaly. GO annotations related to this gene include calmodulin binding and microtubule binding. An important paralog of this gene is MAP6D1.

UniProtKB/Swiss-Prot for MAP6 Gene

  • Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B.

Gene Wiki entry for MAP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP6 Gene

Genomics for MAP6 Gene

Regulatory Elements for MAP6 Gene

Genomic Location for MAP6 Gene

Start:
75,586,918 bp from pter
End:
75,669,120 bp from pter
Size:
82,203 bases
Orientation:
Minus strand

Genomic View for MAP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP6 Gene

Proteins for MAP6 Gene

  • Protein details for MAP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JE9-MAP6_HUMAN
    Recommended name:
    Microtubule-associated protein 6
    Protein Accession:
    Q96JE9
    Secondary Accessions:
    • A7E2A1
    • Q6P3T0
    • Q6ZWB8

    Protein attributes for MAP6 Gene

    Size:
    813 amino acids
    Molecular mass:
    86505 Da
    Quaternary structure:
    • Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca(2+) (By similarity). Interacts with TMEM106B.
    SequenceCaution:
    • Sequence=AAH63860.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP6 Gene

Proteomics data for MAP6 Gene at MOPED

Post-translational modifications for MAP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP6 Gene

No data available for DME Specific Peptides for MAP6 Gene

Domains for MAP6 Gene

Protein Domains for MAP6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP6 Gene

Graphical View of Domain Structure for InterPro Entry

Q96JE9

UniProtKB/Swiss-Prot:

MAP6_HUMAN :
  • Q96JE9
Family:
  • Belongs to the STOP family.
genes like me logo Genes that share domains with MAP6: view

No data available for Gene Families for MAP6 Gene

Function for MAP6 Gene

Molecular function for MAP6 Gene

GENATLAS Biochemistry: microtubule associated protein 6 acting on the stability and dynamics of microtubules
UniProtKB/Swiss-Prot Function: Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B.

Gene Ontology (GO) - Molecular Function for MAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24357581
GO:0005516 calmodulin binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with MAP6: view

Phenotypes for MAP6 Gene

genes like me logo Genes that share phenotypes with MAP6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAP6 Gene

Localization for MAP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP6 Gene

Cytoplasm, cytoskeleton. Golgi apparatus. Note=Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP6 Gene COMPARTMENTS Subcellular localization image for MAP6 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 2
mitochondrion 2
nucleus 2
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005874 microtubule IDA 17210638
GO:0048471 perinuclear region of cytoplasm IDA 17210638
genes like me logo Genes that share ontologies with MAP6: view

Pathways for MAP6 Gene

SuperPathways for MAP6 Gene

No Data Available

Interacting Proteins for MAP6 Gene

Gene Ontology (GO) - Biological Process for MAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0006810 transport IEA --
GO:0032418 lysosome localization IMP 24357581
GO:0048813 dendrite morphogenesis IMP 24357581
genes like me logo Genes that share ontologies with MAP6: view

No data available for Pathways by source for MAP6 Gene

Transcripts for MAP6 Gene

Unigene Clusters for MAP6 Gene

Microtubule-associated protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP6 Gene

No ASD Table

Relevant External Links for MAP6 Gene

GeneLoc Exon Structure for
MAP6
ECgene alternative splicing isoforms for
MAP6

Expression for MAP6 Gene

mRNA expression in normal human tissues for MAP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAP6 Gene

SOURCE GeneReport for Unigene cluster for MAP6 Gene Hs.585540

mRNA Expression by UniProt/SwissProt for MAP6 Gene

Q96JE9-MAP6_HUMAN
Tissue specificity: Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmanns area 46) of patients with schizophrenia (postmortem brain study).
genes like me logo Genes that share expressions with MAP6: view

No data available for mRNA differential expression in normal tissues for MAP6 Gene

Orthologs for MAP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP6 35
  • 99.1 (n)
  • 98.28 (a)
MAP6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP6 35
  • 82.77 (n)
  • 77.59 (a)
MAP6 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP6 35
  • 84.46 (n)
  • 78.01 (a)
MAP6 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map6 35
  • 78.39 (n)
  • 73.19 (a)
Map6 16
Map6 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP6 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map6 35
  • 79.24 (n)
  • 72.85 (a)
chicken
(Gallus gallus)
Aves MAP6 35
  • 70.21 (n)
  • 66.76 (a)
MAP6 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP6 36
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MAP6 (1 of 2) 36
  • 48 (a)
OneToMany
map6a 35
  • 64 (n)
  • 58.65 (a)
map6a 36
  • 44 (a)
OneToMany
Species with no ortholog for MAP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP6 Gene

ENSEMBL:
Gene Tree for MAP6 (if available)
TreeFam:
Gene Tree for MAP6 (if available)

Paralogs for MAP6 Gene

Paralogs for MAP6 Gene

genes like me logo Genes that share paralogs with MAP6: view

Variants for MAP6 Gene

Sequence variations from dbSNP and Humsavar for MAP6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs75954 -- 75,596,886(+) CAAGC(A/G)AGGGA intron-variant
rs479150 -- 75,613,499(-) TCTCT(A/G)GGATG intron-variant
rs507686 -- 75,614,241(+) CCCTG(C/T)GGCTG intron-variant
rs512500 -- 75,664,134(-) GATGG(A/G)TTTCA intron-variant
rs516573 -- 75,629,101(-) AAAAA(A/G)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP6 Gene

Variant ID Type Subtype PubMed ID
nsv897923 CNV Loss 21882294
esv2744784 CNV Deletion 23290073
esv2675287 CNV Deletion 23128226

Relevant External Links for MAP6 Gene

HapMap Linkage Disequilibrium report
MAP6
Human Gene Mutation Database (HGMD)
MAP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP6 Gene

Disorders for MAP6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MAP6 Gene including...

Search for MAP6 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MAP6 Gene

Relevant External Links for MAP6

Genetic Association Database (GAD)
MAP6
Human Genome Epidemiology (HuGE) Navigator
MAP6
genes like me logo Genes that share disorders with MAP6: view

No data available for UniProtKB/Swiss-Prot for MAP6 Gene

Publications for MAP6 Gene

  1. Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia. (PMID: 16624526) Shimizu H. … Yoshikawa T. (Schizophr. Res. 2006) 3 4 23 48
  2. Assignment of the STOP gene (MAP6) to human chromosome bands 6p12-->p11 by fluorescence in situ hybridization. (PMID: 10516426) Jolly C. … Job D. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. Cloning, expression, and properties of the microtubule-stabilizing protein STOP. (PMID: 8700896) Bosc C. … Margolis R.L. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 23
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  5. The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders. (PMID: 12231625) Andrieux A. … Job D. (Genes Dev. 2002) 2 3

Products for MAP6 Gene

Sources for MAP6 Gene

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