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Aliases for MAP6 Gene

Aliases for MAP6 Gene

  • Microtubule Associated Protein 6 2 3 5
  • Stable Tubule-Only Polypeptide 3 4
  • MAP-6 3 4
  • STOP 3 4
  • CTD-2530H12.7 3
  • KIAA1878 4
  • MAP6-N 3
  • N-STOP 3
  • MTAP6 3

External Ids for MAP6 Gene

Previous GeneCards Identifiers for MAP6 Gene

  • GC06U990078
  • GC11U900013
  • GC11M075536
  • GC11M075040
  • GC11M075024
  • GC11M074975
  • GC11M075297
  • GC11M071595

Summaries for MAP6 Gene

Entrez Gene Summary for MAP6 Gene

  • This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP6 Gene

MAP6 (Microtubule Associated Protein 6) is a Protein Coding gene. Diseases associated with MAP6 include tick-borne relapsing fever and schizophrenia. GO annotations related to this gene include microtubule binding and calmodulin binding. An important paralog of this gene is MAP6D1.

UniProtKB/Swiss-Prot for MAP6 Gene

  • Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B.

Gene Wiki entry for MAP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP6 Gene

Genomics for MAP6 Gene

Regulatory Elements for MAP6 Gene

Genomic Location for MAP6 Gene

75,586,914 bp from pter
75,669,120 bp from pter
82,207 bases
Minus strand

Genomic View for MAP6 Gene

Genes around MAP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP6 Gene

Proteins for MAP6 Gene

  • Protein details for MAP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microtubule-associated protein 6
    Protein Accession:
    Secondary Accessions:
    • A7E2A1
    • Q6P3T0
    • Q6ZWB8

    Protein attributes for MAP6 Gene

    813 amino acids
    Molecular mass:
    86505 Da
    Quaternary structure:
    • Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca(2+) (By similarity). Interacts with TMEM106B.
    • Sequence=AAH63860.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP6 Gene


neXtProt entry for MAP6 Gene

Proteomics data for MAP6 Gene at MOPED

Post-translational modifications for MAP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP6 Gene

No data available for DME Specific Peptides for MAP6 Gene

Domains & Families for MAP6 Gene

Protein Domains for MAP6 Gene


Suggested Antigen Peptide Sequences for MAP6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STOP family.
  • Belongs to the STOP family.
genes like me logo Genes that share domains with MAP6: view

No data available for Gene Families for MAP6 Gene

Function for MAP6 Gene

Molecular function for MAP6 Gene

GENATLAS Biochemistry:
microtubule associated protein 6 acting on the stability and dynamics of microtubules
UniProtKB/Swiss-Prot Function:
Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B.
genes like me logo Genes that share phenotypes with MAP6: view

Animal Models for MAP6 Gene

MGI Knock Outs for MAP6:

Animal Model Products

miRNA for MAP6 Gene

miRTarBase miRNAs that target MAP6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP6 Gene

Localization for MAP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP6 Gene

Cytoplasm, cytoskeleton. Golgi apparatus. Note=Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS).

Subcellular locations from

Jensen Localization Image for MAP6 Gene COMPARTMENTS Subcellular localization image for MAP6 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 3
mitochondrion 2
nucleus 2
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MAP6 Gene

Pathways & Interactions for MAP6 Gene

SuperPathways for MAP6 Gene

No Data Available

Interacting Proteins for MAP6 Gene

Gene Ontology (GO) - Biological Process for MAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with MAP6: view

No data available for Pathways by source and SIGNOR curated interactions for MAP6 Gene

Drugs & Compounds for MAP6 Gene

No Compound Related Data Available

Transcripts for MAP6 Gene

Unigene Clusters for MAP6 Gene

Microtubule-associated protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP6 Gene

No ASD Table

Relevant External Links for MAP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP6 Gene

mRNA expression in normal human tissues for MAP6 Gene

Protein differential expression in normal tissues from HIPED for MAP6 Gene

This gene is overexpressed in Brain (30.9), Frontal cortex (19.7), and Platelet (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAP6 Gene

SOURCE GeneReport for Unigene cluster for MAP6 Gene Hs.585540

mRNA Expression by UniProt/SwissProt for MAP6 Gene

Tissue specificity: Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmanns area 46) of patients with schizophrenia (postmortem brain study).
genes like me logo Genes that share expression patterns with MAP6: view

Protein tissue co-expression partners for MAP6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAP6 Gene

Orthologs for MAP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAP6 35
  • 82.77 (n)
  • 77.59 (a)
MAP6 36
  • 76 (a)
(Canis familiaris)
Mammalia MAP6 35
  • 84.46 (n)
  • 78.01 (a)
MAP6 36
  • 62 (a)
(Mus musculus)
Mammalia Map6 35
  • 78.39 (n)
  • 73.19 (a)
Map6 16
Map6 36
  • 61 (a)
(Pan troglodytes)
Mammalia MAP6 35
  • 99.1 (n)
  • 98.28 (a)
MAP6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Map6 35
  • 79.24 (n)
  • 72.85 (a)
(Ornithorhynchus anatinus)
Mammalia MAP6 36
  • 64 (a)
(Gallus gallus)
Aves MAP6 35
  • 70.21 (n)
  • 66.76 (a)
MAP6 36
  • 66 (a)
(Anolis carolinensis)
Reptilia MAP6 36
  • 53 (a)
(Danio rerio)
Actinopterygii map6a 35
  • 64 (n)
  • 58.65 (a)
MAP6 (1 of 2) 36
  • 48 (a)
map6a 36
  • 44 (a)
Species with no ortholog for MAP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP6 Gene

Gene Tree for MAP6 (if available)
Gene Tree for MAP6 (if available)

Paralogs for MAP6 Gene

Paralogs for MAP6 Gene

genes like me logo Genes that share paralogs with MAP6: view

Variants for MAP6 Gene

Sequence variations from dbSNP and Humsavar for MAP6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12225010 - 75,667,629(+) CGCAC(A/C)ATCCA nc-transcript-variant, reference, missense
rs507686 -- 75,614,241(+) CCCTG(C/T)GGCTG intron-variant
rs479150 -- 75,613,499(-) TCTCT(A/G)GGATG intron-variant, upstream-variant-2KB
rs527048 -- 75,660,137(+) aactt(C/T)ttcat intron-variant
rs512500 -- 75,664,134(-) GATGG(A/G)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP6 Gene

Variant ID Type Subtype PubMed ID
nsv897923 CNV Loss 21882294
esv2744784 CNV Deletion 23290073
esv2675287 CNV Deletion 23128226

Variation tolerance for MAP6 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP6 Gene

Disorders for MAP6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAP6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tick-borne relapsing fever
  • relapsing fever, tick-borne
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search MAP6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAP6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP6 Gene

Publications for MAP6 Gene

  1. Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia. (PMID: 16624526) Shimizu H. … Yoshikawa T. (Schizophr. Res. 2006) 3 4 23 48 67
  2. Assignment of the STOP gene (MAP6) to human chromosome bands 6p12-->p11 by fluorescence in situ hybridization. (PMID: 10516426) Jolly C. … Job D. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders. (PMID: 12231625) Andrieux A. … Job D. (Genes Dev. 2002) 2 3
  4. Cloning, expression, and properties of the microtubule-stabilizing protein STOP. (PMID: 8700896) Bosc C. … Margolis R.L. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 23
  5. The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes. (PMID: 24357581) Schwenk B.M. … Edbauer D. (EMBO J. 2014) 3

Products for MAP6 Gene

Sources for MAP6 Gene

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