MAP6 Gene
protein-coding GIFtS: 50
GCID: GC11M075297
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microtubule-associated protein 6
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Aliases
for MAP6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Microtubule-Associated Protein 61 2 | | MAP-62 3 | | STOP1 2 3 | | FLJ413461 | | KIAA18781 3 | | MTAP62 | | Stable Tubule-Only Polypeptide2 3 | | N-STOP2 |
Export aliases for MAP6 gene to outside databasesPrevious GC identifers: GC06U990078 GC11U900013 GC11M075536 GC11M075040 GC11M075024 GC11M074975 GC11M071595 |
Summaries
for MAP6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAP6:
This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding andcalmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinctisoforms have been identified for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MAP6_HUMAN, Q96JE9Function: Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically hasmicrotubule cold stabilizing activity
Gene Wiki entry for MAP6
|
Genomic Views
for MAP6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP6 gene promoter:
PPAR-gamma1 Elk-1 POU2F1 POU2F1a c-Myb PPAR-gamma2 Zic3 c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q13.5MAP6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M075297: view genomic region
(about GC identifiers)
Start:
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75,297,963 bp from pter |
End:
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75,380,165 bp from pter |
Size:
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82,203 bases |
Orientation:
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minus strand |
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Proteins
for MAP6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAP6_HUMAN, Q96JE9 (See
protein sequence)Recommended Name: Microtubule-associated protein 6 Size: 813 amino acids; 86505 Da
Subunit: Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca(2+) (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Golgi apparatus (By similarity). Note=Colocalizes with neurofilament(NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS)
Sequence caution: Sequence=AAH63860.1; Type=Erroneous initiation;
Secondary accessions: A7E2A1 Q6P3T0Alternative splicing: 2 isoforms: Q96JE9-1 Q96JE9-2 Explore the universe of human proteins at neXtProt for MAP6: NX_Q96JE9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96JE9
MAP6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_149052.1 NP_997460.1
ENSEMBL proteins: ENSP00000307093 ENSP00000434278 ENSP00000415108
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MAP6 for ontologies About GeneDecksing
MAP6 Antibody Products:
Assay Products for MAP6: |
Protein
Domains /
Families
for MAP6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96JE9ProtoNet protein and cluster: Q96JE9 UniProtKB/Swiss-Prot: MAP6_HUMAN, Q96JE9Similarity: Belongs to the STOP family |
Function
for MAP6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAP6_HUMAN, Q96JE9Function: Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically hasmicrotubule cold stabilizing activity Genatlas biochemistry entry for MAP6:microtubule associated protein 6 acting on the stability and dynamics of microtubules
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for MAP6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005516 | calmodulin binding |
IEA | -- | | GO:0008017 | microtubule binding |
IEA | -- |
MAP6 for ontologies About GeneDecksing
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Map6):
MAP6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAP6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAP6
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/8 Interacting proteins for MAP6 (Q96JE93 ENSP000003070934) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007026 | negative regulation of microtubule depolymerization |
IEA | -- |
MAP6 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAP6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAP6
Search CenterWatch for drugs/clinical trials and news about MAP6
|
Transcripts
for MAP6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAP6 gene (2 alternative transcripts): NM_033063.1 NM_207577.1 Unigene Cluster for MAP6: Microtubule-associated protein 6 Hs.585540 [show with all ESTs]Unigene Representative Sequence: BC1502544 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000304771(uc001owu.3) ENST00000526740 ENST00000526689 ENST00000434603(uc001owv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MAP6 (NM_033063) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP6 |
Additional cDNA sequence: AB058781.1 AK054873.1 AK096511.1 AK123340.1 BC041411.1 BC063860.1 BC139780.1 BC150254.1 8 DOTS entries: DT.310930 DT.452419 DT.97793179 DT.40121218 DT.100670491 DT.100748695 DT.101976569 DT.95250794 24/123 AceView cDNA sequences (see all 123): BM678222 AI359642 BU727491 H10424 AI146518 AI929437 BM722298 AI368576 AI077806 BG059683 AI350327 AW118394 BE327485 CD105196 CB156511 AK123340 BX952082 BC041411 NM_033063 AL079854 BQ639076 AI589095 AL134650 NM_207577
GeneLoc Exon Structure
|
Expression
for MAP6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAP6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAGTAGTC
About this image
See MAP6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP6
SOURCE GeneReport for Unigene cluster: Hs.585540
UniProtKB/Swiss-Prot: MAP6_HUMAN, Q96JE9Tissue specificity: Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression isup-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study)
SABiosciences Custom PCR Arrays for MAP6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP6 |
Orthologs
for MAP6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MAP6 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for MAP6 (if available)
TreeFam Gene Tree for MAP6 (if available) |
Paralogs
for MAP6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAP6 gene
- MAP6D12
MAP6 for paralogs About GeneDecksing
|
Genomic Variants
for MAP6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAP6 (75297963 - 75380165 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAP6: --
Human Gene Mutation Database (HGMD): MAP6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP6 |
|
Disorders
/ Diseases
for MAP6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAP6 for disorders About GeneDecksing
OMIM gene information: 601783
OMIM disorders: --
6  diseases for MAP6: About MalaCardsamyotrophic lateral sclerosis (als) amyotrophic lateral sclerosis lateral sclerosis bladder neck obstruction
schizophrenia neuronitis
2 diseases from the University of Copenhagen DISEASES database for MAP6:Bladder neck obstruction Schizophrenia Human Genome Epidemiology (HuGE) Navigator: MAP6 (2 documents)
Export disorders for MAP6 gene to outside databases
|
Publications
for MAP6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAP6 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with MAP6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia. (PubMed id 16624526)1, 2, 9 Shimizu H....Yoshikawa T. (2006)
- Assignment of the STOP gene (MAP6) to human chromosome bands 6p12-->p11 by fluorescence in situ hybridization. (PubMed id 10516426)1, 3, 9 Jolly C....Job D. (1999)
- Stable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosis. (PubMed id 14692697)1, 2 Letournel F.... Eyer J. (2003)
- The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders. (PubMed id 12231625)1, 3 Andrieux A....Job D. (2002)
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
- Cloning, expression, and properties of the microtubule-stabilizing protein STOP. (PubMed id 8700896)1, 9 Bosc C....Margolis R.L. (1996)
- MAP6-F is a temperature sensor that directly binds to and protects microtubules from cold-induced depolymerization. (PubMed id 22904321)1 Delphin C....Andrieux A. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. (PubMed id 19165527)1 Martins-de-Souza D....Turck C.W. (2009)
- Calpain 6 is involved in microtubule stabilization and cytoskeletal organization. (PubMed id 17210638)1 Tonami K....Kurihara H. (2007)
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External Searches for MAP6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAP6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAP6 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MAP6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAP6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MAP6 gene:
Search GeneIP for patents involving MAP6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAP6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MAP6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP6 | | | OriGene Protein Over-expression Lysate for MAP6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAP6 | | OriGene 3'-UTR Clone for MAP6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAP6 | | OriGene Custom Protein Services for MAP6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP6 |
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 | | | MAP6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP6 |
|  |  |  | | | | Search ThermoFisher Antibodies for MAP6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP6 |
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