Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAP4K5 Gene

Aliases for MAP4K5 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5 2 3 5
  • Kinase Homologous To SPS1/STE20 3 4
  • MAPK/ERK Kinase Kinase Kinase 5 3 4
  • Germinal Center Kinase-Related 2 3
  • MEK Kinase Kinase 5 3 4
  • EC 4 61
  • MEKKK 5 3 4
  • KHS 3 4
  • EC 2.7.11 61
  • MAPKKKK5 3
  • GCKR 3
  • KHS1 3

External Ids for MAP4K5 Gene

Previous GeneCards Identifiers for MAP4K5 Gene

  • GC14M048208
  • GC14M044682
  • GC14M048875
  • GC14M049954
  • GC14M050885
  • GC14M031011

Summaries for MAP4K5 Gene

Entrez Gene Summary for MAP4K5 Gene

  • This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP4K5 Gene

MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5) is a Protein Coding gene. Diseases associated with MAP4K5 include Dysgraphia and Writing Disorder. Among its related pathways are TNF signaling (REACTOME) and TRAF Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for MAP4K5 Gene

  • May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Gene Wiki entry for MAP4K5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP4K5 Gene

Genomics for MAP4K5 Gene

Regulatory Elements for MAP4K5 Gene

Enhancers for MAP4K5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F050395 0.2 ENCODE 18.8 +164.2 164176 3.0 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GATA2 SP3 MXD4 REST MAP4K5 CDKL1 ATL1 LOC105370487
GH14F050520 1.2 FANTOM5 Ensembl ENCODE 18 +38.1 38064 5.5 HDGF PKNOX1 SIN3A BMI1 FOS CREM ZNF680 JUNB TBX21 IKZF1 MAP4K5 CDKL1 NIN SAV1 PYGL ATL1 LOC100419913
GH14F050675 1.5 FANTOM5 Ensembl ENCODE 18 -115.9 -115889 4.0 PKNOX1 TAF1 JUN RELA GATA3 EED RCOR1 FOS CREM MTA2 MAP4K5 ATL1 NIN CDKL1 SAV1 GC14P050697
GH14F050607 0.8 FANTOM5 ENCODE 17.6 -47.3 -47284 2.2 IKZF1 MAP4K5 ATL1 ABHD12B NIN TRIM9 RN7SL452P SNRPGP1
GH14F050362 0.6 Ensembl ENCODE 15.7 +196.0 196008 4.6 HDGF PKNOX1 ARID4B SIN3A ZNF2 GLIS2 ZNF207 ZNF263 SP3 KAT8 MAP4K5 ATP5S CDKL1 ATL1 GC14M050341 GC14M050342 LOC105370487
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MAP4K5 on UCSC Golden Path with GeneCards custom track

Promoters for MAP4K5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001024120 425 2200 SIN3A GLIS2 ZNF366 SCRT2 EGR2 ZNF263 SP3 YY2 MIER1 MIER2

Genomic Location for MAP4K5 Gene

50,418,480 bp from pter
50,561,126 bp from pter
142,647 bases
Minus strand

Genomic View for MAP4K5 Gene

Genes around MAP4K5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP4K5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP4K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4K5 Gene

Proteins for MAP4K5 Gene

  • Protein details for MAP4K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase kinase 5
    Protein Accession:
    Secondary Accessions:
    • Q8IYF6

    Protein attributes for MAP4K5 Gene

    846 amino acids
    Molecular mass:
    95040 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with both SH3 domains of the adapter proteins CRK and CRKL.

neXtProt entry for MAP4K5 Gene

Selected DME Specific Peptides for MAP4K5 Gene


Post-translational modifications for MAP4K5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for MAP4K5

Domains & Families for MAP4K5 Gene

Protein Domains for MAP4K5 Gene

Suggested Antigen Peptide Sequences for MAP4K5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CNH domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
  • Contains 1 CNH domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP4K5: view

Function for MAP4K5 Gene

Molecular function for MAP4K5 Gene

GENATLAS Biochemistry:
mitogen-activated kinase kinase kinase kinase 5,widely expressed,S cerevisiae STE20 family homolog,activating in N terminal kinase,potentially involved in the stress response of fibroblast
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Enzyme Numbers (IUBMB) for MAP4K5 Gene

Gene Ontology (GO) - Molecular Function for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS 9038372
GO:0004674 protein serine/threonine kinase activity IEA,IDA 9038372
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 9788432
genes like me logo Genes that share ontologies with MAP4K5: view
genes like me logo Genes that share phenotypes with MAP4K5: view

Animal Models for MAP4K5 Gene

MGI Knock Outs for MAP4K5:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAP4K5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP4K5 Gene

Localization for MAP4K5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP4K5 Gene


Subcellular locations from

Jensen Localization Image for MAP4K5 Gene COMPARTMENTS Subcellular localization image for MAP4K5 gene
Compartment Confidence
cytosol 4
plasma membrane 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA 9038372
genes like me logo Genes that share ontologies with MAP4K5: view

Pathways & Interactions for MAP4K5 Gene

genes like me logo Genes that share pathways with MAP4K5: view

Pathways by source for MAP4K5 Gene

2 BioSystems pathways for MAP4K5 Gene
1 GeneGo (Thomson Reuters) pathway for MAP4K5 Gene
3 Qiagen pathways for MAP4K5 Gene

SIGNOR curated interactions for MAP4K5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IEA --
GO:0006468 protein phosphorylation IEA,IDA 9038372
GO:0007257 activation of JUN kinase activity TAS 9038372
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction IDA 9038372
genes like me logo Genes that share ontologies with MAP4K5: view

Drugs & Compounds for MAP4K5 Gene

(4) Drugs for MAP4K5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for MAP4K5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAP4K5: view

Transcripts for MAP4K5 Gene

Unigene Clusters for MAP4K5 Gene

Mitogen-activated protein kinase kinase kinase kinase 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - -
SP2: - - -
SP5: -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b · 34c · 34d
SP4: -

Relevant External Links for MAP4K5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP4K5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP4K5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP4K5 Gene

This gene is overexpressed in Breast (36.4) and Peripheral blood mononuclear cells (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP4K5 Gene

Protein tissue co-expression partners for MAP4K5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP4K5 Gene:


SOURCE GeneReport for Unigene cluster for MAP4K5 Gene:


mRNA Expression by UniProt/SwissProt for MAP4K5 Gene:

Tissue specificity: Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate.
genes like me logo Genes that share expression patterns with MAP4K5: view

Primer Products

No data available for mRNA differential expression in normal tissues for MAP4K5 Gene

Orthologs for MAP4K5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP4K5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP4K5 34 35
  • 99.65 (n)
(Canis familiaris)
Mammalia MAP4K5 34 35
  • 95.11 (n)
(Bos Taurus)
Mammalia MAP4K5 34 35
  • 94.17 (n)
(Mus musculus)
Mammalia Map4k5 34 16 35
  • 89.36 (n)
(Rattus norvegicus)
Mammalia Map4k5 34
  • 88.57 (n)
(Monodelphis domestica)
Mammalia MAP4K5 35
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia MAP4K5 35
  • 22 (a)
(Gallus gallus)
Aves MAP4K5 34 35
  • 80.22 (n)
(Anolis carolinensis)
Reptilia MAP4K5 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia map4k5 34
  • 74.48 (n)
Str.195 34
(Danio rerio)
Actinopterygii map4k5 34 35
  • 70.08 (n)
zgc55719 34
fruit fly
(Drosophila melanogaster)
Insecta CG7097 36
  • 73 (a)
hppy 35
  • 38 (a)
(Caenorhabditis elegans)
Secernentea gck-2 35
  • 42 (a)
ZC404.9 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIC1 35
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
Species where no ortholog for MAP4K5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP4K5 Gene

Gene Tree for MAP4K5 (if available)
Gene Tree for MAP4K5 (if available)

Paralogs for MAP4K5 Gene

Variants for MAP4K5 Gene

Sequence variations from dbSNP and Humsavar for MAP4K5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10047860 -- 50,509,617(+) ATTAT(C/T)GAATA intron-variant
rs10047945 -- 50,509,603(+) ACATT(C/T)TGAAA intron-variant
rs10129680 -- 50,473,311(+) TTTTA(C/T)GGAAA intron-variant
rs10131236 -- 50,507,982(+) gagtt(G/T)aagtc intron-variant
rs10131375 -- 50,438,967(+) TATGA(C/T)ACAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP4K5 Gene

Variant ID Type Subtype PubMed ID
esv2674140 CNV deletion 23128226
esv28926 CNV gain+loss 19812545
esv3634480 CNV loss 21293372
nsv1039493 CNV gain 25217958
nsv1054247 CNV loss 25217958
nsv1131138 CNV deletion 24896259
nsv564835 CNV gain 21841781
nsv832793 CNV loss 17160897

Variation tolerance for MAP4K5 Gene

Gene Damage Index Score: 5.97; 74.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP4K5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4K5 Gene

Disorders for MAP4K5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAP4K5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • agraphia
writing disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAP4K5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAP4K5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP4K5 Gene

Publications for MAP4K5 Gene

  1. A novel human SPS1/STE20 homologue, KHS, activates jun N-terminal kinase. (PMID: 9038372) Tung R.M. … Blenis J. (Oncogene 1997) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). (PMID: 12591926) Shi C.S. … Kehrl J.H. (J. Biol. Chem. 2003) 3 22 64
  4. Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation. (PMID: 10648385) Shi C.S. … Kehrl J.H. (Blood 2000) 3 22 64
  5. TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway. (PMID: 10490605) Chin A.I. … Cheng G. (Mol. Cell. Biol. 1999) 3 22 64

Products for MAP4K5 Gene

Sources for MAP4K5 Gene

Loading form....