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Aliases for MAP4K5 Gene

Aliases for MAP4K5 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5 2 3
  • Kinase Homologous To SPS1/STE20 3 4
  • MAPK/ERK Kinase Kinase Kinase 5 3 4
  • Germinal Center Kinase-Related 2 3
  • MEK Kinase Kinase 5 3 4
  • EC 4 63
  • MAPKKKK5 3 6
  • MEKKK 5 3 4
  • KHS 3 4
  • EC 2.7.11 63
  • GCKR 3
  • KHS1 3

External Ids for MAP4K5 Gene

Previous GeneCards Identifiers for MAP4K5 Gene

  • GC14M048208
  • GC14M044682
  • GC14M048875
  • GC14M049954
  • GC14M050885
  • GC14M031011

Summaries for MAP4K5 Gene

Entrez Gene Summary for MAP4K5 Gene

  • This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP4K5 Gene

MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for MAP4K5 Gene

  • May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Gene Wiki entry for MAP4K5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP4K5 Gene

Genomics for MAP4K5 Gene

Regulatory Elements for MAP4K5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAP4K5 Gene

50,418,493 bp from pter
50,561,126 bp from pter
142,634 bases
Minus strand

Genomic View for MAP4K5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP4K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4K5 Gene

Proteins for MAP4K5 Gene

  • Protein details for MAP4K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase kinase 5
    Protein Accession:
    Secondary Accessions:
    • Q8IYF6

    Protein attributes for MAP4K5 Gene

    846 amino acids
    Molecular mass:
    95040 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with both SH3 domains of the adapter proteins CRK and CRKL.

neXtProt entry for MAP4K5 Gene

Proteomics data for MAP4K5 Gene at MOPED

Post-translational modifications for MAP4K5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP4K5 Gene

Antibody Products

Domains for MAP4K5 Gene

Gene Families for MAP4K5 Gene

  • MAP4K :Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases

Protein Domains for MAP4K5 Gene

Suggested Antigen Peptide Sequences for MAP4K5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y4K4
  • Contains 1 CNH domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP4K5: view

Function for MAP4K5 Gene

Molecular function for MAP4K5 Gene

GENATLAS Biochemistry: mitogen-activated kinase kinase kinase kinase 5,widely expressed,S cerevisiae STE20 family homolog,activating in N terminal kinase,potentially involved in the stress response of fibroblast
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Enzyme Numbers (IUBMB) for MAP4K5 Gene

Gene Ontology (GO) - Molecular Function for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9038372
GO:0004674 protein serine/threonine kinase activity IDA 9038372
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with MAP4K5: view
genes like me logo Genes that share phenotypes with MAP4K5: view

Animal Models for MAP4K5 Gene

MGI Knock Outs for MAP4K5:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for MAP4K5 Gene

Localization for MAP4K5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP4K5 Gene


Subcellular locations from

Jensen Localization Image for MAP4K5 Gene COMPARTMENTS Subcellular localization image for MAP4K5 gene
Compartment Confidence
plasma membrane 4
cytosol 3
cytoskeleton 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with MAP4K5: view

Pathways for MAP4K5 Gene

genes like me logo Genes that share pathways with MAP4K5: view

Pathways by source for MAP4K5 Gene

3 Qiagen pathways for MAP4K5 Gene
2 BioSystems pathways for MAP4K5 Gene

Gene Ontology (GO) - Biological Process for MAP4K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 9038372
GO:0007257 activation of JUN kinase activity TAS 9038372
GO:0035556 intracellular signal transduction IDA 9038372
genes like me logo Genes that share ontologies with MAP4K5: view

Compounds for MAP4K5 Gene

(3) HMDB Compounds for MAP4K5 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium

(2) Novoseek inferred chemical compound relationships for MAP4K5 Gene

Compound -log(P) Hits PubMed IDs
threonine 56.1 3
serine 35.8 2
genes like me logo Genes that share compounds with MAP4K5: view

Transcripts for MAP4K5 Gene

Unigene Clusters for MAP4K5 Gene

Mitogen-activated protein kinase kinase kinase kinase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP4K5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - -
SP2: - - -
SP5: -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b · 34c · 34d
SP4: -

Relevant External Links for MAP4K5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP4K5 Gene

mRNA expression in normal human tissues for MAP4K5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP4K5 Gene

SOURCE GeneReport for Unigene cluster for MAP4K5 Gene Hs.130491

mRNA Expression by UniProt/SwissProt for MAP4K5 Gene

Tissue specificity: Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate.
genes like me logo Genes that share expressions with MAP4K5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAP4K5 Gene

Orthologs for MAP4K5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP4K5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP4K5 35
  • 99.65 (n)
  • 99.76 (a)
MAP4K5 36
  • 100 (a)
(Bos Taurus)
Mammalia MAP4K5 35
  • 94.17 (n)
  • 97.52 (a)
MAP4K5 36
  • 97 (a)
(Canis familiaris)
Mammalia MAP4K5 35
  • 95.11 (n)
  • 98.23 (a)
MAP4K5 36
  • 98 (a)
(Mus musculus)
Mammalia Map4k5 35
  • 89.36 (n)
  • 96.22 (a)
Map4k5 16
Map4k5 36
  • 96 (a)
(Monodelphis domestica)
Mammalia MAP4K5 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia MAP4K5 36
  • 22 (a)
(Rattus norvegicus)
Mammalia Map4k5 35
  • 88.57 (n)
  • 96.69 (a)
(Gallus gallus)
Aves MAP4K5 35
  • 80.22 (n)
  • 90.96 (a)
MAP4K5 36
  • 88 (a)
(Anolis carolinensis)
Reptilia MAP4K5 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia map4k5 35
  • 74.48 (n)
  • 82.14 (a)
Str.195 35
(Danio rerio)
Actinopterygii map4k5 35
  • 70.08 (n)
  • 78.72 (a)
map4k5 36
  • 76 (a)
zgc55719 35
fruit fly
(Drosophila melanogaster)
Insecta hppy 36
  • 38 (a)
CG7097 37
  • 73 (a)
(Caenorhabditis elegans)
Secernentea gck-2 36
  • 42 (a)
ZC404.9 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIC1 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for MAP4K5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP4K5 Gene

Gene Tree for MAP4K5 (if available)
Gene Tree for MAP4K5 (if available)

Paralogs for MAP4K5 Gene

Paralogs for MAP4K5 Gene

genes like me logo Genes that share paralogs with MAP4K5: view

Variants for MAP4K5 Gene

Sequence variations from dbSNP and Humsavar for MAP4K5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs3267 -- 50,479,565(+) tgact(C/T)gggcc intron-variant
rs768580 -- 50,444,582(-) CTGTA(A/G)AGATG intron-variant
rs974318 -- 50,530,867(-) CCTCC(C/T)AATTA intron-variant
rs974319 -- 50,530,771(-) TTATT(C/G)CTTAA intron-variant
rs1065395 -- 50,464,087(-) AAAAC(A/C)CAAAA missense, reference, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAP4K5 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545
nsv832793 CNV Loss 17160897
esv2674140 CNV Deletion 23128226

Relevant External Links for MAP4K5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4K5 Gene

Disorders for MAP4K5 Gene

(2) Novoseek inferred disease relationships for MAP4K5 Gene

Disease -log(P) Hits PubMed IDs
necrosis 19.8 1
tumors 0 1

Relevant External Links for MAP4K5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAP4K5: view

No data available for UniProtKB/Swiss-Prot for MAP4K5 Gene

Publications for MAP4K5 Gene

  1. A novel human SPS1/STE20 homologue, KHS, activates jun N-terminal kinase. (PMID: 9038372) Tung R.M. … Blenis J. (Oncogene 1997) 2 3 4 23
  2. GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway. (PMID: 9949177) Shi C.S. … Kehrl J.H. (Blood 1999) 3 23
  3. TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related. (PMID: 10477597) Shi C.S. … Kehrl J.H. (J. Immunol. 1999) 3 23
  4. TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway. (PMID: 10490605) Chin A.I. … Cheng G. (Mol. Cell. Biol. 1999) 3 23
  5. Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation. (PMID: 10648385) Shi C.S. … Kehrl J.H. (Blood 2000) 3 23

Products for MAP4K5 Gene

Sources for MAP4K5 Gene

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