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MAP4K5 Gene

protein-coding   GIFtS: 67
GCID: GC14M050885

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5

  Search for MAP4K5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 51 2     MEKKK 52 3
Germinal Center Kinase-Related1 2     EC 2.7.11.13 8
Kinase Homologous To SPS1/STE202 3     MAPKKKK52 5
KHS2 3     GCKR2
MAPK/ERK Kinase Kinase Kinase 52 3     KHS12
MEK Kinase Kinase 52 3     EC 2.7.118

External Ids:    HGNC: 68671   Entrez Gene: 111832   Ensembl: ENSG000000129837   OMIM: 6049235   UniProtKB: Q9Y4K43   

Export aliases for MAP4K5 gene to outside databases

Previous GC identifers: GC14M048208 GC14M044682 GC14M048875 GC14M049954 GC14M031011


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP4K5 Gene:
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast
SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is
essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which
suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have
been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP4K5 Gene:
MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and small GTPase regulator activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: M4K5_HUMAN, Q9Y4K4
Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal
pathway

Gene Wiki entry for MAP4K5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP4K5 gene promoter:
         AP-1   MyoD   CUTL1   LCR-F1   Arnt   CP2   FOXO1a   STAT3   NF-kappaB1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP4K5 promoter sequence
   Search Chromatin IP Primers for MAP4K5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP4K5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2-q21   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q11.2-q21

MAP4K5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4K5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M050885:  view genomic region     (about GC identifiers)

Start:
50,885,211 bp from pter      End:
51,027,844 bp from pter
Size:
142,634 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: M4K5_HUMAN, Q9Y4K4 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 5  
Size: 846 amino acids; 95040 Da
Cofactor: Magnesium
Subunit: Interacts with both SH3 domains of the adapter proteins CRK and CRKL
Secondary accessions: Q8IYF6

Explore the universe of human proteins at neXtProt for MAP4K5: NX_Q9Y4K4

Explore proteomics data for MAP4K5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP4K5 (Q9Y4K4) (see all 23)
     QLYSHNL  PKKRPTA  GITAIEL  MEQLFPR 


    See MAP4K5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006566.2  NP_942089.1  

    ENSEMBL proteins: 
     ENSP00000013125   ENSP00000451926   ENSP00000452289   ENSP00000451980   ENSP00000451452  

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    Sino Biological Cell Lysate for MAP4K5
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    Cloud-Clone Corp. Proteins for MAP4K5

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP4K: Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase kinase 5
    KHS subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR001180 Citron

    Graphical View of Domain Structure for InterPro Entry Q9Y4K4

    ProtoNet protein and cluster: Q9Y4K4

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: M4K5_HUMAN, Q9Y4K4
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAP4K5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M4K5_HUMAN, Q9Y4K4
    Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal
    pathway
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for MAP4K5:
    mitogen-activated kinase kinase kinase kinase 5,widely expressed,S cerevisiae STE20 family homolog,activating in N
    terminal kinase,potentially involved in the stress response of fibroblast

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9038372
    GO:0004674protein serine/threonine kinase activity IDA9038372
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding IPI17474147
         
    Find genes that share ontologies with MAP4K5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAP4K5:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory  Increased mitotic index 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Map4k5):
     behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     integument 

    Find genes that share phenotypes with MAP4K5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Map4k5tm1Jhk for MAP4K5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP4K5
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    hsa-miR-323-3p hsa-miR-3163 hsa-miR-31 hsa-miR-548k hsa-miR-183 hsa-miR-128 hsa-miR-3681* hsa-miR-3159
    SwitchGear 3'UTR luciferase reporter plasmidMAP4K5 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for MAP4K5 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    M4K5_HUMAN, Q9Y4K4: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    cytoskeleton2
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with MAP4K5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP4K5 About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51
    2TRAF Pathway
    TRAF Pathway0.42
    3TNF receptor signaling pathway
    TNF receptor signaling pathway
    4Signal transduction JNK pathway
    Signal transduction JNK pathway
    5Insulin Signaling
    Insulin Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP4K5
        TRAF Pathway
    JNK Pathway
    MAPK Family Pathway

    1 GeneGo (Thomson Reuters) Pathway for MAP4K5
        Signal transduction JNK pathway

    2 BioSystems Pathways for MAP4K5
        Insulin Signaling
    TNF receptor signaling pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAP4K5
    Interactions:

        GeneGlobe Interaction Network for MAP4K5

    Selected Interacting proteins for MAP4K5 (Q9Y4K41, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 3EBI-1279,EBI-401755 I2D: score=6 
    CRKP461081, 3EBI-1279,EBI-886 I2D: score=4 
    FYNP062412, 3MINT-8111355 I2D: score=3 
    NCK1P163331, 3EBI-1279,EBI-389883 I2D: score=2 
    SETDB1Q150472, 3MINT-8260493 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9038372
    GO:0007257activation of JUN kinase activity TAS9038372
    GO:0035556intracellular signal transduction IDA9038372

    Find genes that share ontologies with MAP4K5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP4K5 (M4K5)

    3 HMDB Compounds for MAP4K5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for MAP4K5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 56.1 3 9405407 (1), 10477597 (1), 10648385 (1)
    serine 35.8 2 9405407 (1), 10648385 (1)



    Find genes that share compounds with MAP4K5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAP4K5 gene (2 alternative transcripts): 
    NM_006575.4  NM_198794.2  

    Unigene Cluster for MAP4K5:

    Mitogen-activated protein kinase kinase kinase kinase 5
    Hs.130491  [show with all ESTs]
    Unigene Representative Sequence: NM_198794
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554990(uc001wyc.1) ENST00000013125(uc010anv.1 uc001wya.3 uc001wyb.3)
    ENST00000557124 ENST00000557210 ENST00000554091 ENST00000557578 ENST00000555216
    ENST00000557390 ENST00000554066 ENST00000554273
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAP4K5 (see all 10):
    hsa-miR-323-3p hsa-miR-3163 hsa-miR-31 hsa-miR-548k hsa-miR-183 hsa-miR-128 hsa-miR-3681* hsa-miR-3159
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    Additional mRNA sequence: 

    AK313612.1 BC013159.1 BC036013.1 U77129.1 Z25426.1 

    12 DOTS entries:

    DT.95291648  DT.101959365  DT.95366315  DT.99964716  DT.413201  DT.95358982  DT.100788343  DT.101959920 
    DT.101961168  DT.101965377  DT.91669081  DT.91746460 

    Selected AceView cDNA sequences (see all 124):

    NM_198794 AK124738 BC013159 CR618486 AW007921 AW468987 AI683938 BF433148 
    AI350786 AI867009 CA415092 T28050 CA944493 CB215010 AA708269 AA737502 
    CB528538 AI472606 NM_006575 AL135026 AW169590 BF793267 CD106242 BC036013 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K5 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:              -                             -                                                     -           -                                             
    SP2:                                            -                                                     -           -                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                              -                                             

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b · 34c · 34d
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                              -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for MAP4K5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAP4K5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCTTCTGA
    MAP4K5 Expression
    About this image


    MAP4K5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    MAP4K5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP4K5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.130491

    UniProtKB/Swiss-Prot: M4K5_HUMAN, Q9Y4K4
    Tissue specificity: Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and
    prostate

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP4K5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map4k51 , 5 mitogen-activated protein kinase kinase kinase kinase more1, 5 89.36(n)1
    96.22(a)1
      12 (28.94 cM)5
    3995101  NM_201519.21  NP_958927.21 
     698037505 
    chicken
    (Gallus gallus)
    Aves MAP4K51 mitogen-activated protein kinase kinase kinase kinase more 80.22(n)
    90.96(a)
      423576  XM_004936498.1  XP_004936555.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAP4K56
    mitogen-activated protein kinase kinase kinase kin...
    85(a)
    1 ↔ 1
    GL343627.1(23288-141315)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.1952 Transcribed sequence with moderate similarity to protein more 80.41(n)    AL778200.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc557192 hypothetical protein MGC55719 74.34(n)   393419  BC055001.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70973 protein amino acid phosphorylation
    receptor signaling more
    73(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ZC404.93 serine/threonine kinase 40(a)   V(6791490-6795261)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIC16
    Protein kinase of the PAK/Ste20 family, required f...
    19(a)
    1 → many
    VIII(316572-319814) YHR102W


    ENSEMBL Gene Tree for MAP4K5 (if available)
    TreeFam Gene Tree for MAP4K5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP4K5 gene
    TAOK22  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    Selected SIMAP similar genes for MAP4K5 using alignment to 6 protein entries:     M4K5_HUMAN (see all proteins) (see all similar genes):
    MINK1    MAP4K3    MAP4K1    MAP4K2    CDK2    TNIK
    DKFZp686J1430    CDK12    STK24    STK4    MAP4K4    TAOK3
    STK25    CDK1    MST4    STK11    PAK2    MYO3A

    Find genes that share paralogs with MAP4K5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP4K5 (see all 2105)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1141093021,2
    F--50884731(+) TACTTT/CTTCTT 2 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1884949071,2
    --50884891(+) GGATGA/GTGGGA 2 -- ds50010--------
    rs1420111541,2
    --50884897(+) TGGGAC/TTGCCA 2 -- ds50010--------
    rs762356471,2
    C,F--50885013(+) AGAGAA/GGACTC 2 -- ds50013Minor allele frequency- G:0.04WA NA EA 358
    rs1923384011,2
    --50885143(+) CATCTA/GCTGTA 2 -- ds50010--------
    rs2014122501,2
    C--50885169(+) ATAGCA/CAAAAT 2 -- ds50010--------
    rs1845032411,2
    --50885236(+) ACTTTA/GTATTC 2 -- ut310--------
    rs1896056091,2
    --50885247(+) CATTTA/GTATAA 2 -- ut310--------
    rs1500773571,2
    --50885300(+) AGAAGA/GCTCAT 2 -- ut310--------
    rs1385351631,2
    --50885332(+) TGCTGC/TGTAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MAP4K5 (50885211 - 51027844 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MAP4K5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674140CNV Deletion23128226
    nsv832793CNV Loss17160897
    esv28926CNV Gain+Loss19812545

    Human Gene Mutation Database (HGMD): MAP4K5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP4K5
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP4K5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604923    OMIM disorders: --


    Find genes that share disorders with MAP4K5           About GenesLikeMe

    2 Novoseek inferred disease relationships for MAP4K5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 19.8 1 12591926 (1)
    tumors 0 1 12591926 (1)

    Genetic Association Database (GAD): MAP4K5
    Human Genome Epidemiology (HuGE) Navigator: MAP4K5 (1 document)

    Export disorders for MAP4K5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP4K5 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with MAP4K5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human SPS1/STE20 homologue, KHS, activates jun N-terminal kinase. (PubMed id 9038372)1, 2, 3, 9 Tung R.M. and Blenis J. (Oncogene 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. (PubMed id 9788432)1, 2 Oehrl W.... Feller S.M. (Oncogene 1998)
    4. Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. (PubMed id 8274451)1, 3 Schultz S.J. and Nigg E.A. (Cell Growth Differ. 1993)
    5. Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation. (PubMed id 10648385)1, 9 Shi C.S....Kehrl J.H. (Blood 2000)
    6. TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related. (PubMed id 10477597)1, 9 Shi C.S....Kehrl J.H. (J. Immunol. 1999)
    7. GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway. (PubMed id 9949177)1, 9 Shi C.S....Kehrl J.H. (Blood 1999)
    8. Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). (PubMed id 12591926)1, 9 Shi C.S. and Kehrl J.H. (J. Biol. Chem. 2003)
    9. TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway. (PubMed id 10490605)1, 9 Chin A.I....Cheng G. (Mol. Cell. Biol. 1999)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11183 HGNC: 6867 AceView: MAP4K5 Ensembl:ENSG00000012983 euGenes: HUgn11183
    ECgene: MAP4K5 H-InvDB: MAP4K5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAP4K5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAP4K5 gene:
    Search GeneIP for patents involving MAP4K5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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