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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAP4K5 Gene

protein-coding GIFtS: 64
GCID: GC14M050885

mitogen-activated protein kinase kinase kinase kinase 5

Explore 2 diseases affiliated with
MAP4K5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5¹ ²		MEK Kinase Kinase 5² ³
KHS¹ ² ³		MEKKK 5² ³
GCKR¹ ²		EC 2.7.11.1³ ⁸
KHS1¹ ²		MAPKKKK5² ⁵
Kinase Homologous To SPS1/STE20² ³		Germinal Center Kinase-Related²
MAPK/ERK Kinase Kinase Kinase 5² ³		EC 2.7.11⁸

External Ids:	HGNC: 6867¹	Entrez Gene: 11183²	Ensembl: ENSG00000012983⁷	OMIM: 604923⁵	UniProtKB: Q9Y4K4³

Export aliases for MAP4K5 gene to outside databases

Previous GC identifers: GC14M048208 GC14M044682 GC14M048875 GC14M049954 GC14M031011

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP4K5:

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20

kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast

pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress

response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: M4K5_HUMAN, Q9Y4K4

Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal

pathway

Gene Wiki entry for MAP4K5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAP4K5 gene promoter:
AP-1 MyoD CUTL1 LCR-F1 Arnt CP2 FOXO1a STAT3 NF-kappaB1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAP4K5 promoter sequence

Search SABiosciences Chromatin IP Primers for MAP4K5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP4K5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2-q21 Ensembl cytogenetic band: 14q22.1 HGNC cytogenetic band: 14q11.2-q21

MAP4K5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4K5 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M050885: view genomic region (about GC identifiers)

Start:	50,885,219 bp from pter	End:	51,027,844 bp from pter
Size:	142,626 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: M4K5_HUMAN, Q9Y4K4 (See protein sequence)

Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 5

Size: 846 amino acids; 95040 Da

Cofactor: Magnesium

Subunit: Interacts with both SH3 domains of the adapter proteins CRK and CRKL

Subcellular location: Cytoplasm

Secondary accessions: Q8IYF6

Explore the universe of human proteins at neXtProt for MAP4K5: NX_Q9Y4K4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y4K4

4/23 DME Specific Peptides for MAP4K5 (Q9Y4K4) (see all 23)

QLYSHNL

PKKRPTA

GITAIEL

MEQLFPR

MAP4K5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_006566.2 NP_942089.1

ENSEMBL proteins:

ENSP00000013125 ENSP00000451926 ENSP00000452289 ENSP00000451980 ENSP00000451452

Human Recombinant Protein Products for MAP4K5:

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	Novus Biologicals MAP4K5 Proteins Novus Biologicals MAP4K5 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAP4K5

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	--

MAP4K5 for ontologies About GeneDecksing

MAP4K5 Antibody Products:

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Assay Products for MAP4K5:

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	Uscn ELISAs and CLIAs for MAP4K5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAP4K5 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_cat_dom

IPR001180 Citron

Graphical View of Domain Structure for InterPro Entry Q9Y4K4

ProtoNet protein and cluster: Q9Y4K4

1 Blocks protein family: IPB001180 Citron-like

UniProtKB/Swiss-Prot: M4K5_HUMAN, Q9Y4K4

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily

Similarity: Contains 1 CNH domain

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: M4K5_HUMAN, Q9Y4K4

Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal

pathway

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Genatlas biochemistry entry for MAP4K5:

mitogen-activated kinase kinase kinase kinase 5,widely expressed,S cerevisiae STE20 family homolog,activating in N

terminal kinase,potentially involved in the stress response of fibroblast

Enzyme Numbers (IUBMB): EC 2.7.11.1¹ ² EC 2.7.11²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	TAS	9038372
GO:0004674	protein serine/threonine kinase activity	IDA	9038372
GO:0005083	small GTPase regulator activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IDA	9038372

MAP4K5 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for MAP4K5:

Decreased focal adhesion (FA)

Increased gamma-H2AX phosphory

Increased mitotic index

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Map4k5):

behavior/neurological	cellular	hematopoietic system	homeostasis/metabolism	immune system
integument

MAP4K5 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Map4k5^tm1Jhk for MAP4K5

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MAP4K5

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MAP4K5 Browse MicroRNA Expression Plasmids
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		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP4K5 (see all 10):
		hsa-miR-323-3p hsa-miR-3163 hsa-miR-31 hsa-miR-548k hsa-miR-183 hsa-miR-128 hsa-miR-3681* hsa-miR-3159

		SwitchGear 3'UTR luciferase reporter plasmid: MAP4K5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MAP4K5
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP4K5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP4K5 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MAP4K5 (NM_006575)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP4K5
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MAP4K5
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signal transduction_JNK pathway

Signal transduction_JNK pathway

1.00

Signal transduction JNK pathway

0.98

TGF-Beta Pathway

MAPK Family Pathway

0.60

JNK Pathway

0.50

TRAF Pathway

TRAF Pathway

1.00

Insulin Signaling

Insulin Signaling

1.00

TNF receptor signaling pathway

TNF receptor signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MAP4K5

Signal transduction JNK pathway

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP4K5

	TRAF Pathway
	JNK Pathway
	MAPK Family Pathway

1 GeneGo (Thomson Reuters) Pathway for MAP4K5

Signal transduction JNK pathway

2 BioSystems Pathways for MAP4K5

	Insulin Signaling
	TNF receptor signaling pathway

MAP4K5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MAP4K5

5/22 Interacting proteins for MAP4K5 (Q9Y4K4^{1, 2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993¹^,³	EBI-1279,EBI-401755 I2D: score=6
CRK	P46108¹^,³	EBI-1279,EBI-886 I2D: score=4
FYN	P06241²^,³	MINT-8111355 I2D: score=3
NCK1	P16333¹^,³	EBI-1279,EBI-3448658 I2D: score=2
SETDB1	Q15047²^,³	MINT-8260493 I2D: score=2

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	IDA	9038372
GO:0006950	response to stress	IDA	9038372
GO:0007243	intracellular protein kinase cascade	IDA	9038372
GO:0007257	activation of JUN kinase activity	TAS	9038372

MAP4K5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MAP4K5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAP4K5

3 HMDB Compounds for MAP4K5 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

2 Novoseek chemical compound relationships for MAP4K5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	56.1	3	9405407 (1), 10477597 (1), 10648385 (1)
serine	35.8	2	9405407 (1), 10648385 (1)

Search CenterWatch for drugs/clinical trials and news about MAP4K5 / M4K5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAP4K5 gene (2 alternative transcripts):

NM_006575.4 NM_198794.2

Unigene Cluster for MAP4K5:

Mitogen-activated protein kinase kinase kinase kinase 5

Hs.130491 [show with all ESTs]

Unigene Representative Sequence: NM_198794

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000554990(uc001wyc.1) ENST00000013125(uc010anv.1 uc001wya.3 uc001wyb.3)

ENST00000555033 ENST00000557124 ENST00000557210 ENST00000554091 ENST00000557578

ENST00000555216 ENST00000557390 ENST00000554066 ENST00000554273

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MAP4K5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP4K5
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP4K5 (see all 10):
		hsa-miR-323-3p hsa-miR-3163 hsa-miR-31 hsa-miR-548k hsa-miR-183 hsa-miR-128 hsa-miR-3681* hsa-miR-3159

		SwitchGear 3'UTR luciferase reporter plasmid: MAP4K5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP4K5 (see all 4) OriGene shRNA RFP: MAP4K5 OriGene siRNA: MAP4K5
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MAP4K5

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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP4K5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP4K5

Additional cDNA sequence:

AK313612.1 BC013159.1 BC036013.1 U77129.1 Z25426.1

13 DOTS entries:

DT.95291648 DT.101959365 DT.95366315 DT.99964716 DT.413201 DT.95358982 DT.100788343 DT.101959920

DT.101961168 DT.101965377 DT.91669081 DT.91746460 DT.92325066

24/124 AceView cDNA sequences (see all 124):

CB528538 BM552067 AI472606 H99050 BU754037 AK124738 CR618486 BP376323

AI867009 AI683938 AI367359 AL135026 AA708269 BF433148 AA737502 AW169590

CA415092 CB215010 BF793267 AI744912 CA502884 AI350786 AW007921 BC036013

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K5 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18a	·	18b	^	19	^	20	^	21	^	22	^
SP1:					-										-																		-				-
SP2:															-																		-				-
SP3:
SP4:
SP5:																																					-

ExUns:	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34a	·	34b	·	34c	·	34d
SP1:
SP2:
SP3:
SP4:																					-
SP5:

ECgene alternative splicing isoforms for MAP4K5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAP4K5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTCTTCTGA

About this image

MAP4K5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Right Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MAP4K5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP4K5

SOURCE GeneReport for Unigene cluster: Hs.130491

UniProtKB/Swiss-Prot: M4K5_HUMAN, Q9Y4K4

Tissue specificity: Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate

SABiosciences Custom PCR Arrays for MAP4K5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP4K5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP4K5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP4K5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MAP4K5 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MAP4K5¹	mitogen-activated protein kinase kinase kinase kinase more	80.71(n) 91.19(a)		423576 XM_421465.3 XP_421465.2
lizard (Anolis carolinensis)	Reptilia	MAP4K5⁶ --	--	87(a) 11(a)	1 ↔ 1 possible ortholog	GL343627.1(59262-139265) 3(123450519-123503589)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.195²	Transcribed sequence with moderate similarity to protein more	80.41(n)		AL778200.2
zebrafish (Danio rerio)	Actinopterygii	zgc55719²	hypothetical protein MGC55719	74.34(n)		393419 BC055001.1
fruit fly (Drosophila melanogaster)	Insecta	CG7097³	protein amino acid phosphorylation receptor signaling more	73(a)		--

ENSEMBL Gene Tree for MAP4K5 (if available)
TreeFam Gene Tree for MAP4K5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MAP4K5 gene

TAOK2² TAOK3² NRK² TNIK² MAP4K2² MAP4K1² MAP4K3² MAP4K4²

TAOK1² STK10² MINK1² SLK²

18/82 SIMAP similar genes for MAP4K5 using alignment to 6 protein entries: M4K5_HUMAN (see all proteins) (see all similar genes):

MINK1 MAP4K3 MAP4K1 MAP4K2 CDK2 TNIK

DKFZp686J1430 CDK12 STK24 STK4 MAP4K4 TAOK3

STK25 CDK1 MST4 STK11 PAK2 MYO3A

MAP4K5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75264362^1,2		--	31123280(+)	`TCATCA/GTTTGT`	1	--	us2k¹		0	--	--	--	--
rs78947507^1,2		--	31123584(+)	`TTTTTT/AAAAAA`	1	--	us2k¹		1		CSA	2
rs55940722^1,2	C,F	--	31124050(+)	`CCGCCT/GCAGGA`	1	--	us2k¹		1		EA	120
rs118189385^1,2	C,F	--	31124500(+)	`GCACCC/TGCGTC`	1	--	us2k¹		1		NA	120
rs17122643^1,2	C,F	--	31124909(-)	`CTTCCT/CCTACC`	1	--	us2k¹ trp³		2		WA EA	238
rs74050944^1,2	C	--	31124962(+)	`GGTACG/ATTAAG`	1	--	us2k¹		2		WA	120
rs56831794^1,2	C	--	31125315(+)	`AGTATG/ATGCTC`	1	--	ut5¹		2		WA	120
rs17718872^1,2	C,F,H	--	31126063(+)	`GGCTTC/TGATGA`	1	--	int¹		27		NA EA NS	2880
rs114109302^1,2	F	--	50884731(+)	`TACTTT/CTTCTT`	2	--	ds500¹		1		WA	118
rs188494907^1,2		--	50884891(+)	`GGATGA/GTGGGA`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MAP4K5 (50885219 - 51027844 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAP4K5
1 CNV: 66642
Human Gene Mutation Database (HGMD): MAP4K5

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAP4K5 for disorders           About GeneDecksing

OMIM gene information: 604923    OMIM disorders: --

2 diseases for MAP4K5:    About MalaCards

dysgraphia prostatitis

1 disease from the University of Copenhagen DISEASES database for MAP4K5:

Dysgraphia

2 Novoseek disease relationships for MAP4K5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	19.8	1	12591926 (1)
tumors	0	1	12591926 (1)

Human Genome Epidemiology (HuGE) Navigator: MAP4K5 (1 document)

Export disorders for MAP4K5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MAP4K5 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with MAP4K5)

Utopia: connect your pdf to the dynamic
world of online information

A novel human SPS1/STE20 homologue, KHS, activates jun N-terminal kinase. (PubMed id 9038372)^{1, 2, 3, 9} Tung R.M. and Blenis J. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. (PubMed id 9788432)^{1, 2} Oehrl W.... Feller S.M. (1998)
Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. (PubMed id 8274451)^{1, 3} Schultz S.J. and Nigg E.A. (1993)
Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation. (PubMed id 10648385)^{1, 9} Shi C.S....Kehrl J.H. (2000)
TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related. (PubMed id 10477597)^{1, 9} Shi C.S....Kehrl J.H. (1999)
GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway. (PubMed id 9949177)^{1, 9} Shi C.S....Kehrl J.H. (1999)
Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). (PubMed id 12591926)^{1, 9} Shi C.S. and Kehrl J.H. (2003)
TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway. (PubMed id 10490605)^{1, 9} Chin A.I....Cheng G. (1999)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11183	HGNC: 6867	AceView: MAP4K5	Ensembl:ENSG00000012983	euGenes: HUgn11183
ECgene: MAP4K5	H-InvDB: MAP4K5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MAP4K5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MAP4K5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MAP4K5 gene:
Search GeneIP for patents involving MAP4K5

GeneCards and IP:
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mitogen-activated protein kinase kinase kinase kinase 5

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mitogen-activated protein kinase kinase kinase kinase 5

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