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MAP4K4 Gene

protein-coding   GIFtS: 65
GCID: GC02P102313

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 41 2     HPK/GCK-Like Kinase1
Hepatocyte Progenitor Kinase-Like/Germinal Center Kinase-Like Kinase1 2     FLH219572
Nck-Interacting Kinase2 3     HEL-S-312
HGK2 3     MEKKK42
NIK2 3     Epididymis Secretory Protein Li 312
HPK/GCK-Like Kinase HGK2 3     Ste20 Group Protein Kinase HGK2
MAPK/ERK Kinase Kinase Kinase 42 3     KIAA06873
MEK Kinase Kinase 42 3     MEKKK 43
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 68661   Entrez Gene: 94482   Ensembl: ENSG000000710547   OMIM: 6046665   UniProtKB: O958193   

Export aliases for MAP4K4 gene to outside databases

Previous GC identifers: GC02P100178 GC02P100767 GC02P101919 GC02P101935 GC02P101773 GC02P096078


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP4K4 Gene:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been
shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the
dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may
function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway.
Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MAP4K4 Gene:
MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4) is a protein-coding gene. Diseases associated with MAP4K4 include progressive supranuclear palsy, and frontotemporal dementia. GO annotations related to this gene include protein serine/threonine kinase activity and small GTPase regulator activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: M4K4_HUMAN, O95819
Function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such
as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322

Gene Wiki entry for MAP4K4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MAP4K4 gene promoter:
         C/EBPbeta   AML1a   Pbx1a   HSF2   Msx-1   C/EBPalpha   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP4K4 promoter sequence
   Search Chromatin IP Primers for MAP4K4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP4K4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2-q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2-q12

MAP4K4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4K4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P102313:  view genomic region     (about GC identifiers)

Start:
102,313,312 bp from pter      End:
102,511,152 bp from pter
Size:
197,841 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: M4K4_HUMAN, O95819 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 4  
Size: 1239 amino acids; 142101 Da
Cofactor: Magnesium
Subunit: Interacts with the SH3 domain of the adapter proteins Nck (By similarity). Interacts (via its CNH
regulatory domain) with ATL1 (via the N-terminal region). Interacts with RAP2A (GTP-bound form preferentially)
Secondary accessions: O75172 Q9NST7
Alternative splicing: 5 isoforms:  O95819-1   O95819-2   O95819-3   O95819-4   O95819-5   (Variant in position: 682:D->V)

Explore the universe of human proteins at neXtProt for MAP4K4: NX_O95819

Explore proteomics data for MAP4K4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys46, Lys1179, Lys1198
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP4K4 (O95819) (see all 31)
     RNDKVFF  PFIRDQP  WMAPEVI  MEFCGAGS 


    See MAP4K4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001229488.1  NP_001229489.1  NP_004825.3  NP_663719.2  NP_663720.1  

    ENSEMBL proteins: 
     ENSP00000403016   ENSP00000392830   ENSP00000389752   ENSP00000314363   ENSP00000387370  
     ENSP00000409720   ENSP00000396066   ENSP00000414766   ENSP00000313644   ENSP00000281111  
     ENSP00000303600   ENSP00000343658  
    Reactome Protein details: O95819

    MAP4K4 Human Recombinant Protein Products:

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    MAP4K4 Assay Products:

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    Cloud-Clone Corp. ELISAs for MAP4K4
    Cloud-Clone Corp. CLIAs for MAP4K4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP4K: Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase kinase 4
    MSN subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O95819

    ProtoNet protein and cluster: O95819

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: M4K4_HUMAN, O95819
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    MAP4K4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M4K4_HUMAN, O95819
    Function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such
    as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for MAP4K4:
    mitogen-activated kinase kinase kinase kinase 4,S cerevisiae STE20 family homolog,specifically activating the JNK
    signaling through the pathway TAK1

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA9890973
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
         
    MAP4K4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAP4K4:
     Increased cell death in HCC-19  Increased cell transformation 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Map4k4):
     embryogenesis  growth/size/body  limbs/digits/tail  mortality/aging 

    MAP4K4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Map4k4tm1Eys for MAP4K4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP4K4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP4K4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP4K4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP4K4

    miRNA
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    Block miRNA regulation of human, mouse, rat MAP4K4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP4K4 (see all 129):
    hsa-miR-579 hsa-miR-548j hsa-miR-323-3p hsa-miR-200a hsa-miR-30d hsa-miR-632 hsa-miR-519a hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidMAP4K4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP4K4
    Predesigned siRNA for gene silencing in human, mouse, rat MAP4K4

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MAP4K4 (see all 19)
    OriGene ORF clones in mouse, rat for MAP4K4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAP4K4 (NM_145686)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP4K4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K4

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    M4K4_HUMAN, O95819: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA14966141

    MAP4K4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP4K4 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2EPHB forward signaling
    EPHB forward signaling0.30
    Cell adhesion Ephrins signaling0.30
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    4TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51
    5MAPK targets/ Nuclear events mediated by MAP kinases
    MAP Kinase Signaling0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP4K4
        JNK Pathway
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP4K4
        MAP Kinase Signaling

    2 GeneGo (Thomson Reuters) Pathways for MAP4K4
        Signal transduction JNK pathway
    Cell adhesion Ephrins signaling

    Selected BioSystems Pathways for MAP4K4 (see all 6)
        MAPK signaling pathway
    Insulin Signaling
    Direct p53 effectors
    Ceramide signaling pathway
    EPHB forward signaling

    1 Reactome Pathway for MAP4K4
        Oxidative Stress Induced Senescence


    1 Kegg Pathway  (Kegg details for MAP4K4):
        MAPK signaling pathway


    MAP4K4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MAP4K4: 
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP4K4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP4K4 (O958191, 2, 3 ENSP000003136444) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GBP3Q9H0R51, 2, 3, ENSP000003595124EBI-2511133,EBI-2798916 MINT-7032884 MINT-7032897 MINT-7032915 MINT-7032935 I2D: score=2 STRING: ENSP00000359512
    SLC9A1P196343, ENSP000002639804I2D: score=4 STRING: ENSP00000263980
    MAP3K7O433183, ENSP000003583354I2D: score=3 STRING: ENSP00000358335
    PRKCEQ021563, ENSP000003061244I2D: score=3 STRING: ENSP00000306124
    MAP3K1Q132333, ENSP000003824234I2D: score=2 STRING: ENSP00000382423
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9890973
    GO:0023014signal transduction by phosphorylation IBA--
    GO:0035556intracellular signal transduction IDA9890973
    GO:0046328regulation of JNK cascade IDA14966141

    MAP4K4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP4K4 (M4K4)

    3 HMDB Compounds for MAP4K4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    5 Novoseek inferred chemical compound relationships for MAP4K4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parthenolide 65.2 1 15006539 (1)
    serine 34 8 9135144 (1), 9890973 (1), 9799091 (1), 12612079 (1)
    threonine 31.7 8 9135144 (1), 9890973 (1), 9799091 (1), 12612079 (1)
    tyrosine 13.5 4 10669731 (2), 16455978 (1)
    oxygen 0 2 12704649 (2)



    MAP4K4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAP4K4 gene (5 alternative transcripts): 
    NM_001242559.1  NM_001242560.1  NM_004834.4  NM_145686.3  NM_145687.3  

    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427603 ENST00000425019(uc002tbf.3) ENST00000413150(uc002tbd.3 uc010yvy.2 uc002tbh.3 uc002tbg.3 uc002tbc.3)
    ENST00000347699 ENST00000456652(uc002tbi.3 uc002tbk.3 uc021vlq.1 uc002tbl.3)
    ENST00000417294(uc010yvz.2) ENST00000496989 ENST00000489490 ENST00000476609(uc002tbj.1)
    ENST00000421882 ENST00000418101 ENST00000477711 ENST00000498066 ENST00000491743
    ENST00000324219 ENST00000350198(uc010fiw.1) ENST00000302217 ENST00000350878


    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAP4K4 (see all 129):
    hsa-miR-579 hsa-miR-548j hsa-miR-323-3p hsa-miR-200a hsa-miR-30d hsa-miR-632 hsa-miR-519a hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidMAP4K4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): MAP4K4 (NM_145686)
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      QuantiTect SYBR Green Assays in human, mouse, rat MAP4K4
      QuantiFast Probe-based Assays in human, mouse, rat MAP4K4

    Selected AceView cDNA sequences (see all 410):

    CA419247 BU838389 CA443406 BG499811 AA450155 BF856741 CR606880 BQ014222 
    AA703462 BM449898 AL707377 AL707931 BM759205 BU731384 BQ228004 AI205841 
    CA440969 AB014587 BM772976 CD671490 AL137755 CA446217 T34464 AA281382 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP4K4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGATGGT
    MAP4K4 Expression
    About this image


    MAP4K4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Testis (Reproductive System)
     
     Adipose (Muscoskeletal System)
    MAP4K4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP4K4 Protein Expression

    UniProtKB/Swiss-Prot: M4K4_HUMAN, O95819
    Tissue specificity: Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more
    abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including MAP4K4: 
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP4K4
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    QuantiFast Probe-based Assays in human, mouse, rat MAP4K4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAP4K4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map4k41 , 5 mitogen-activated protein kinase kinase kinase kinase more1, 5 86.18(n)1
    91.89(a)1
      1 (18.53 cM)5
    269211  NM_001252200.11  NP_001239129.11 
     399009135 
    chicken
    (Gallus gallus)
    Aves MAP4K41 mitogen-activated protein kinase kinase kinase kinase more 84.39(n)
    94.08(a)
      418714  XM_416913.4  XP_416913.4 
    lizard
    (Anolis carolinensis)
    Reptilia MAP4K46
    mitogen-activated protein kinase kinase kinase kin...
    80(a)
    1 ↔ 1
    GL343243.1(1824480-2017575)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX689006.12   -- 82.62(n)    BX689006.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wu:fa03e111 wu:fa03e11 73.38(n)
    87.04(a)
      100004003  XM_001343390.5  XP_001343426.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta msn3 JNK cascade protein serine/threonine
    kinase
    79(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ZC504.4c3   -- 67(a)
    (best of 3)
      X(10457433-10463808)   --


    ENSEMBL Gene Tree for MAP4K4 (if available)
    TreeFam Gene Tree for MAP4K4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP4K4 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  
    STK102  TAOK12  MINK12  SLK2  
    Selected SIMAP similar genes for MAP4K4 using alignment to 15 protein entries:     M4K4_HUMAN (see all proteins) (see all similar genes):
    MINK1    TNIK    MYO3A    MAP4K2    MAP4K5    MYO3B
    MAP4K3    CDKL3    STK3    MAP4K1    PAK4    STK25
    STK4/SLC36AL fusion    STK24    TBK1    MST4    STK4    CDK1

    MAP4K4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP4K4 (see all 3834)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815297111,2
    --96076068(+) GAATAC/TTTGGT 2 -- us2k10--------
    rs559237181,2
    C--96232086(+) TTTTT-/T/TT/TTT/TTTTT
    TTTTTTTTTTTTTTTTT
    GCCTT
    10 -- int1 cds11NA 2
    rs1435766671,2
    C--102312361(+) TCTCA-/AAAC  
            
    AAACA
    3 -- us2k10--------
    rs723319181,2
    C--102312364(+) TCTCA-/AAAC  
            
    AAACA
    3 -- us2k10--------
    rs359175981,2
    C,F--102312403(+) TAAGAT/CAGCCT 3 -- us2k17Minor allele frequency- C:0.35WA NA CSA EA 366
    rs1156946781,2
    F--102312406(+) GATAGC/TCTGAA 3 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1483543371,2
    --102312652(+) GATAGG/TGCTAT 5 -- us2k10--------
    rs1127304951,2
    C,F--102312895(+) GACACA/TGTATG 5 -- us2k12Minor allele frequency- T:0.06NA 122
    rs1862731791,2
    --102313168(+) CGGTGA/GAGGAA 5 -- us2k10--------
    rs1909872031,2
    --102313502(+) AACGAA/GGGACT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP4K4 (102313312 - 102511152 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAP4K4 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2829CNV Deletion18987735
    esv2720455CNV Deletion23290073
    esv2632369CNV Deletion19546169
    esv2661163CNV Deletion23128226
    esv2663691CNV Deletion23128226
    esv2720452CNV Deletion23290073
    esv2669350CNV Deletion23128226
    esv2061482CNV Deletion18987734
    esv2109649CNV Deletion18987734
    esv1631190CNV Deletion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP4K4
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP4K4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604666    OMIM disorders: --

    17 diseases for MAP4K4:    
    About MalaCards
    progressive supranuclear palsy    frontotemporal dementia    pancreatic ductal adenocarcinoma    dementia
    insulin resistance    lung adenocarcinoma    hodgkin's lymphoma    hepatitis b
    retinitis    adenocarcinoma    pancreatic cancer    pancreatitis
    hepatocellular carcinoma    melanoma    hepatitis    endotheliitis
    prostatitis


    MAP4K4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for MAP4K4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 0 1 15006539 (1)
    necrosis 0 2 9506955 (1), 10713108 (1)
    tumors 0 6 12612079 (2), 9506955 (1), 16537454 (1), 10713108 (1)


    Export disorders for MAP4K4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP4K4 gene, integrated from 10 sources (see all 95):
    (articles sorted by number of sources associating them with MAP4K4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. (PubMed id 9890973)1, 2, 3, 9 Yao Z.... Tan T.-H. (J. Biol. Chem. 1999)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    3. The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. (PubMed id 12612079)1, 2, 9 Wright J.H.... Jallal B. (Mol. Cell. Biol. 2003)
    4. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. (PubMed id 9135144)1, 3, 9 Su Y.C....Skolnik E.Y. (EMBO J. 1997)
    5. Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. (PubMed id 14966141)1, 2, 9 Machida N.... Kariya K. (J. Biol. Chem. 2004)
    6. A novel GTP-binding protein hGBP3 interacts with NIK/HGK. (PubMed id 12387898)1, 2 Luan Z.... Hu G. (FEBS Lett. 2002)
    7. The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. (PubMed id 11369779)1, 9 Yan W....Barber D.L. (J. Biol. Chem. 2001)
    8. Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation. (PubMed id 10669731)1, 9 Becker E....Skolnik E.Y. (Mol. Cell. Biol. 2000)
    9. A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. (PubMed id 16537454)1, 9 Collins C.S....Hampton G.M. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    10. Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation. (PubMed id 10805734)1, 9 Zhao Z.S....Lim L. (Mol. Cell. Biol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9448 HGNC: 6866 AceView: MAP4K4 Ensembl:ENSG00000071054 euGenes: HUgn9448
    ECgene: MAP4K4 Kegg: 9448 H-InvDB: MAP4K4

    (According to HUGE)
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    HUGE: KIAA0687

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP4K4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP4K4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAP4K4 gene:
    Search GeneIP for patents involving MAP4K4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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