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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP4K4 Gene

protein-coding   GIFtS: 65
GCID: GC02P102313

mitogen-activated protein kinase kinase kinase kinase 4
 Explore 16 diseases affiliated with
MAP4K4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP4K4    

Aliases
for MAP4K4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 41 2     EC 2.7.11.13 8
HGK1 2 3     MEKKK42
NIK1 2 3     Hepatocyte Progenitor Kinase-Like/Germinal Center Kinase-Like Kinase2
FLH219571 2     Ste20 Group Protein Kinase HGK2
Nck-Interacting Kinase2 3     KIAA06873
HPK/GCK-Like Kinase HGK2 3     MEKKK 43
MAPK/ERK Kinase Kinase Kinase 42 3     EC 2.7.118
MEK Kinase Kinase 42 3     

External Ids:    HGNC: 68661   Entrez Gene: 94482   Ensembl: ENSG000000710547   OMIM: 6046665   UniProtKB: O958193   

Export aliases for MAP4K4 gene to outside databases

Previous GC identifers: GC02P100178 GC02P100767 GC02P101919 GC02P101935 GC02P101773 GC02P096078


Summaries
for MAP4K4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAP4K4:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown
to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the
dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function
through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced
transcript variants encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: M4K4_HUMAN, O95819
Function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as
TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322

Gene Wiki entry for MAP4K4


Genomic Views
for MAP4K4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP4K4 gene promoter:
         C/EBPbeta   AML1a   Pbx1a   HSF2   Msx-1   C/EBPalpha   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP4K4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP4K4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP4K4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2-q12   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2-q12

MAP4K4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4K4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P102313:  view genomic region     (about GC identifiers)

Start:
 102,313,312 bp from pter      End:
 102,511,152 bp from pter
Size:
 197,841 bases      Orientation:
 plus strand

Proteins
for MAP4K4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: M4K4_HUMAN, O95819 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 4  
Size: 1239 amino acids; 142101 Da
Cofactor: Magnesium
Subunit: Interacts with the SH3 domain of the adapter proteins Nck (By similarity). Interacts (via its CNH regulatory
domain) with ATL1 (via the N-terminal region). Interacts with RAP2A (GTP-bound form preferentially)
Subcellular location: Cytoplasm
Secondary accessions: O75172 Q9NST7
Alternative splicing: 5 isoforms:  O95819-1   O95819-2   O95819-3   O95819-4   O95819-5   (Variant in position: 682:D->V)

Explore the universe of human proteins at neXtProt for MAP4K4: NX_O95819

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95819

    • 4/31 DME Specific Peptides for MAP4K4 (O95819) (see all 31)
     RNDKVFF  PFIRDQP  WMAPEVI  MEFCGAGS 

    MAP4K4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001229488.1  NP_001229489.1  NP_004825.3  NP_663719.2  NP_663720.1  

    ENSEMBL proteins: 
     ENSP00000403016   ENSP00000392830   ENSP00000389752   ENSP00000387370   ENSP00000314363  
     ENSP00000409720   ENSP00000396066   ENSP00000414766   ENSP00000313644   ENSP00000281111  
     ENSP00000303600   ENSP00000343658  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAP4K4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA14966141


    MAP4K4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MAP4K4

    Protein Domains /
    Families
    for MAP4K4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP4K4 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O95819

    ProtoNet protein and cluster: O95819

    1 Blocks protein family: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: M4K4_HUMAN, O95819
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    Function
    for MAP4K4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: M4K4_HUMAN, O95819
    Function: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as
    TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for MAP4K4:
    mitogen-activated kinase kinase kinase kinase 4,S cerevisiae STE20 family homolog,specifically activating the JNK
    signaling through the pathway TAK1

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP4K4
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    hsa-miR-579 hsa-miR-548j hsa-miR-323-3p hsa-miR-200a hsa-miR-30d hsa-miR-632 hsa-miR-519a hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmid: MAP4K4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP4K4 (see all 7)
    OriGene shRNA RFP: MAP4K4
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP4K4

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA9890973
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding IPI14966141
    GO:0005524ATP binding IDA9890973


    MAP4K4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MAP4K4:
     Increased cell death in HCC-19  Increased cell transformation 

    Animal Models:
         Mouse knock-out Map4k4tm1Eys for MAP4K4
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Map4k4):
     embryogenesis  growth/size  limbs/digits/tail  mortality/aging 

    MAP4K4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAP4K4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Ephrins signaling
    		Cell adhesion_Ephrins signaling1.00
    		EPHB forward signaling0.30
    		Cell adhesion Ephrins signaling1.00
    2Signal transduction_JNK pathway
    		Signal transduction_JNK pathway1.00
    		Signal transduction JNK pathway0.98
    3MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    4TGF-Beta Pathway
    		MAPK Family Pathway0.60
    		JNK Pathway0.50
    5MAP Kinase Signaling
    		MAP Kinase Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for MAP4K4
        Signal transduction JNK pathway
    Cell adhesion Ephrins signaling

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP4K4
        JNK Pathway
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP4K4
        MAP Kinase Signaling

    2 GeneGo (Thomson Reuters) Pathways for MAP4K4
        Signal transduction JNK pathway
    Cell adhesion Ephrins signaling

    5/6 BioSystems Pathways for MAP4K4 (see all 6) 
        MAPK signaling pathway
    Insulin Signaling
    EPHB forward signaling
    Ceramide signaling pathway
    TNF receptor signaling pathway


    1         Kegg Pathway  (Kegg details for MAP4K4):
        MAPK signaling pathway


    MAP4K4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP4K4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for MAP4K4 (O958192, 3 ENSP000003136444) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GBP3Q9H0R52, 3, ENSP000003595124MINT-7032884 MINT-7032897 MINT-7032915 MINT-7032935 I2D: score=2 STRING: ENSP00000359512
    SLC9A1P196343, ENSP000002639804I2D: score=4 STRING: ENSP00000263980
    MAP3K7O433183, ENSP000003583354I2D: score=3 STRING: ENSP00000358335
    PRKCEQ021563, ENSP000003061244I2D: score=3 STRING: ENSP00000306124
    MAP3K1Q132333, ENSP000003824234I2D: score=2 STRING: ENSP00000382423
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9890973
    GO:0006950response to stress IDA9890973
    GO:0007243intracellular protein kinase cascade IDA9890973
    GO:0046328regulation of JNK cascade IDA14966141


    MAP4K4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP4K4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP4K4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP4K4

    3 HMDB Compounds for MAP4K4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    5 Novoseek chemical compound relationships for MAP4K4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parthenolide 65.2 1 15006539 (1)
    serine 34 8 9135144 (1), 9890973 (1), 9799091 (1), 12612079 (1)
    threonine 31.7 8 9135144 (1), 9890973 (1), 9799091 (1), 12612079 (1)
    tyrosine 13.5 4 10669731 (2), 16455978 (1)
    oxygen 0 2 12704649 (2)

    Search CenterWatch for drugs/clinical trials and news about MAP4K4 / M4K4 

    Transcripts
    for MAP4K4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP4K4 gene (5 alternative transcripts): 
    NM_001242559.1  NM_001242560.1  NM_004834.4  NM_145686.3  NM_145687.3  

    Unigene Cluster for MAP4K4:

    Mitogen-activated protein kinase kinase kinase kinase 4
    Hs.743950  [show with all ESTs]
    Unigene Representative Sequence: NM_145686
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427603 ENST00000425019(uc002tbf.3) ENST00000413150(uc002tbd.3 uc010yvy.2 uc002tbh.3 uc002tbg.3 uc002tbc.3)
    ENST00000456652(uc002tbi.3 uc002tbk.3 uc021vlq.1 uc002tbl.3)
    ENST00000347699 ENST00000417294(uc010yvz.2) ENST00000496989 ENST00000489490
    ENST00000476609(uc002tbj.1) ENST00000421882 ENST00000418101 ENST00000477711
    ENST00000498066 ENST00000491743 ENST00000324219 ENST00000350198(uc010fiw.1)
    ENST00000302217 ENST00000350878

    miRNA
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    8/129 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP4K4 (see all 129):
    hsa-miR-579 hsa-miR-548j hsa-miR-323-3p hsa-miR-200a hsa-miR-30d hsa-miR-632 hsa-miR-519a hsa-miR-4275
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB013385.1 AB014587.1 AF096300.1 AK000380.1 AK001272.1 AK025610.1 AK074592.1 AK130085.1 
    AK295610.1 AK296396.1 AK307879.1 AL137755.1 AY212247.1 AY834276.1 BC010909.1 BC040077.1 
    BC045694.1 BC051791.1 BC054038.1 BC064691.1 BC065036.1 

    24/29 DOTS entries (see all 29):

    DT.445188  DT.100825687  DT.100825686  DT.86842343  DT.100825681  DT.120942047  DT.100038023  DT.95155875 
    DT.91755600  DT.91755597  DT.91755619  DT.40257195  DT.40131976  DT.120941986  DT.120942036  DT.100825679 
    DT.100825684  DT.97828124  DT.100825678  DT.100825682  DT.102837018  DT.120942059  DT.75117937  DT.91755608 

    24/410 AceView cDNA sequences (see all 410):

    BM772976 NM_145686 BQ014222 CA440969 BG109258 BF515878 CA423364 BU630843 
    BE560763 BC040077 BX279744 BC065036 CA777847 BM771356 T34464 BG499811 
    BU629574 BQ045469 BQ228004 BC051791 AW999425 CA443406 AA310905 BF856741 

    GeneLoc Exon Structure


    Expression
    for MAP4K4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP4K4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCAGATGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MAP4K4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP4K4

    SOURCE GeneReport for Unigene cluster: Hs.743950

    UniProtKB/Swiss-Prot: M4K4_HUMAN, O95819
    Tissue specificity: Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more
    abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including MAP4K4: 
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for MAP4K4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP4K4 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAP4K41 mitogen-activated protein kinase kinase kinase kinase more 85.91(n)
    95.85(a)    		   418714  XM_416913.3  XP_416913.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MAP4K46
    		 --
    		 80(a)
    		 1 ↔ 1
    		 GL343243.1(1824480-1897206)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX689006.12   -- 82.62(n)    BX689006.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CU694490.16
    		 --
    		 62(a)
    		 1 ↔ 1
    		 9(444031-468280)
    fruit fly
    (Drosophila melanogaster)    		 Insecta msn3 JNK cascade protein serine/threonine kinase 79(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea ZC504.4c3   -- 67(a)
    (best of 3)    		   X(10457433-10463808)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SIK16
    		 protein kinase domain-containing protein
    		 19(a)
    		 1 → many
    		 1(26020089-26026171)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 STE_PAK_Ste20_KHSh_GCKh_HPKh.1 - STE kinases inclu...
    		 18(a)
    		 1 → many
    		 3(31132935-31141859)


    ENSEMBL Gene Tree for MAP4K4 (if available)
    TreeFam Gene Tree for MAP4K4 (if available) 

    Paralogs
    for MAP4K4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP4K4 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  
    TAOK12  STK102  MINK12  SLK2  
    18/52 SIMAP similar genes for MAP4K4 using alignment to 15 protein entries:     M4K4_HUMAN (see all proteins) (see all similar genes):
    MINK1    TNIK    MYO3A    MAP4K2    MAP4K5    MYO3B
    MAP4K3    CDKL3    STK3    MAP4K1    PAK4    STK25
    STK4/SLC36AL fusion    STK24    TBK1    MST4    STK4    DKFZp686J1430

    MAP4K4 for paralogs           About GeneDecksing



    Genomic Variants
    for MAP4K4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3111 NCBI SNPs in MAP4K4 are shown (see all 3111)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs723319181,2
    		C--102312361(+) TCTCA-/AAAC  
                AAACA     		3 -- us2k10--------
    rs1435766671,2
    		C,--102312361(+) TCTCA-/AAAC  
                AAACA     		3 -- us2k10--------
    rs359175981,2
    		C,F,--102312403(+) TAAGAT/CAGCCT 3 -- us2k17Minor allele frequency- C:0.35WA NA CSA EA 366
    rs1156946781,2
    		F,--102312406(+) GATAGC/TCTGAA 3 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1815297111,2
    		--102312533(+) GAATAC/TTTGGT 3 -- us2k10--------
    rs1483543371,2
    		--102312652(+) GATAGG/TGCTAT 5 -- us2k10--------
    rs1127304951,2
    		C,--102312895(+) GACACA/TGTATG 5 -- us2k12Minor allele frequency- T:0.06NA 122
    rs1862731791,2
    		--102313168(+) CGGTGA/GAGGAA 5 -- us2k10--------
    rs1909872031,2
    		--102313502(+) AACGAA/GGGACT 5 -- us2k10--------
    rs347636041,2
    		C,F,--102313609(+) ACACCC/GGGTTC 5 -- us2k19Minor allele frequency- G:0.19NA WA CSA EA 369

    HapMap Linkage Disequilibrium report for MAP4K4 (102313312 - 102511152 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 20 variations for MAP4K4
         7 CNVs: 38393 89842 5991 89844 97925 97924 78672
         13 Indels: 89841 78673 41633 45828 89843 78670 78671 89845 89846 12089 45827 78674 26395

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    Disorders / Diseases
    for MAP4K4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP4K4 for disorders           About GeneDecksing

    OMIM gene information: 604666    OMIM disorders: --

    16 diseases for MAP4K4:    About MalaCards
    supranuclear palsy    progressive supranuclear palsy    frontotemporal dementia    pancreatic ductal adenocarcinoma
    insulin resistance    hodgkin's lymphoma    dementia    hepatitis b
    hepatocellular carcinoma    adenocarcinoma    pancreatitis    hepatitis
    retinitis    melanoma    carcinoma    prostatitis

    3 Novoseek disease relationships for MAP4K4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 0 1 15006539 (1)
    necrosis 0 2 9506955 (1), 10713108 (1)
    tumors 0 6 12612079 (2), 9506955 (1), 16537454 (1), 10713108 (1)


    Export disorders for MAP4K4 gene to outside databases

    Publications
    for MAP4K4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP4K4 gene, integrated from 9 sources (see all 86):
    (articles sorted by number of sources associating them with MAP4K4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. (PubMed id 9890973)1, 2, 3, 9 Yao Z.... Tan T.-H. (1999)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    3. The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. (PubMed id 12612079)1, 2, 9 Wright J.H.... Jallal B. (2003)
    4. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. (PubMed id 9135144)1, 3, 9 Su Y.C....Skolnik E.Y. (1997)
    5. Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. (PubMed id 14966141)1, 2, 9 Machida N....Kariya K. (2004)
    6. A novel GTP-binding protein hGBP3 interacts with NIK/HGK. (PubMed id 12387898)1, 2 Luan Z.... Hu G. (2002)
    7. The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. (PubMed id 11369779)1, 9 Yan W....Barber D.L. (2001)
    8. Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation. (PubMed id 10669731)1, 9 Becker E....Skolnik E.Y. (2000)
    9. A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. (PubMed id 16537454)1, 9 Collins C.S....Hampton G.M. (2006)
    10. Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation. (PubMed id 10805734)1, 9 Zhao Z.S....Lim L. (2000)

    External Searches for MAP4K4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing MAP4K4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9448 HGNC: 6866 AceView: MAP4K4 Ensembl:ENSG00000071054 euGenes: HUgn9448
    ECgene: MAP4K4 Kegg: 9448 H-InvDB: MAP4K4

    Other Databases showing MAP4K4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0687

    Specialized Databases showing MAP4K4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP4K4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP4K4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAP4K4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP4K4 gene:
    Search GeneIP for patents involving MAP4K4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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