Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MAP4K3 Gene

protein-coding   GIFtS: 64
GCID: GC02M039476

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3


(Previous symbol: RAB8IPL1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 31 2     MEKKK 32 3
RAB8IPL11 2 3     EC 2.7.11.13 8
Germinal Center Kinase-Related Protein Kinase2 3     MAPKKKK32
GLK2 3     MEKKK32
MAPK/ERK Kinase Kinase Kinase 32 3     Germinal Center Kinase-Like Kinase2
MEK Kinase Kinase 32 3     EC 2.7.118

External Ids:    HGNC: 68651   Entrez Gene: 84912   Ensembl: ENSG000000115667   OMIM: 6049215   UniProtKB: Q8IVH83   

Export aliases for MAP4K3 gene to outside databases

Previous GC identifers: GC02M039440 GC02M039623 GC02M039450 GC02M039388 GC02M039329 GC02M039215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MAP4K3 Gene:
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded
protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for MAP4K3 Gene:
MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and small GTPase regulator activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: M4K3_HUMAN, Q8IVH8
Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal
pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP4K3 gene promoter:
         SRF   AML1a   SRF (504 AA)   HTF   CUTL1   RORalpha1   PPAR-alpha   HSF2   Msx-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP4K3 promoter sequence
   Search Chromatin IP Primers for MAP4K3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP4K3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.3

MAP4K3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4K3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M039476:  view genomic region     (about GC identifiers)

Start:
39,476,407 bp from pter      End:
39,664,453 bp from pter
Size:
188,047 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: M4K3_HUMAN, Q8IVH8 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 3  
Size: 894 amino acids; 101316 Da
Cofactor: Magnesium
Subunit: Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation (By similarity)
Secondary accessions: Q6IQ39 Q8IVH7 Q9UDM5 Q9Y6R5
Alternative splicing: 3 isoforms:  Q8IVH8-1   Q8IVH8-2   Q8IVH8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP4K3: NX_Q8IVH8

Explore proteomics data for MAP4K3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP4K3 (Q8IVH8) (see all 25)
     QLYSHNL  LFLMTKS  PKKRPTA  GITAIEL 


    See MAP4K3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257354.1  NP_003609.2  

    ENSEMBL proteins: 
     ENSP00000263881   ENSP00000416958   ENSP00000345434   ENSP00000399228   ENSP00000405137  
     ENSP00000410183   ENSP00000476533   ENSP00000440580  

    MAP4K3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAP4K3
    OriGene Protein Over-expression Lysate for MAP4K3
    OriGene MassSpec for MAP4K3
    OriGene Custom Protein Services for MAP4K3
    GenScript Custom Purified and Recombinant Proteins Services for MAP4K3
    Novus Biologicals MAP4K3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP4K3

     
    Search eBioscience for Proteins for MAP4K3 

     
    Search antibodies-online for proteins for MAP4K3 

     
    antibodies-online peptides for MAP4K3

    MAP4K3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MAP4K3  (KHS2)
    OriGene Antibodies for MAP4K3
    OriGene Custom Antibody Services for MAP4K3
    Novus Biologicals MAP4K3 Antibodies
    Abcam antibodies for MAP4K3
    Cloud-Clone Corp. Antibodies for MAP4K3
    ThermoFisher Antibody for MAP4K3
    antibodies-online antibodies for MAP4K3 (3 products) 

    MAP4K3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAP4K3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP4K3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP4K3
    Cloud-Clone Corp. CLIAs for MAP4K3
    Search eBioscience for ELISAs for MAP4K3 
    antibodies-online kits for MAP4K3 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    MAP4K: Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase kinase 3
    KHS subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR001180 Citron

    Graphical View of Domain Structure for InterPro Entry Q8IVH8

    ProtoNet protein and cluster: Q8IVH8

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: M4K3_HUMAN, Q8IVH8
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAP4K3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M4K3_HUMAN, Q8IVH8
    Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal
    pathway
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9275185
    GO:0004674protein serine/threonine kinase activity IDA9275185
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding IPI17474147
         
    Find genes that share ontologies with MAP4K3           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAP4K3:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death in HCT116  Increased mitotic index 
     Increased telomerase activity 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Map4k3):
     hematopoietic system  immune system 

    Find genes that share phenotypes with MAP4K3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MAP4K3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP4K3:
    hsa-mir-26b-5p (MIRT029966)

    Block miRNA regulation of human, mouse, rat MAP4K3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP4K3 (see all 44):
    hsa-miR-21* hsa-let-7d hsa-miR-429 hsa-let-7a-2* hsa-let-7g hsa-let-7a hsa-miR-200b hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidMAP4K3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP4K3
    Predesigned siRNA for gene silencing in human, mouse, rat MAP4K3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP4K3

    Clone
    Products:
         
    OriGene clones in human, mouse for MAP4K3 (see all 8)
    OriGene ORF clones in mouse, rat for MAP4K3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP4K3 (NM_003618)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP4K3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K3
    Addgene plasmids for MAP4K3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAP4K3
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP4K3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton1
    nucleus1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--

    Find genes that share ontologies with MAP4K3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MAP4K3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51
    3TNF receptor signaling pathway
    TNF receptor signaling pathway
    4Signal transduction JNK pathway
    Signal transduction JNK pathway
    5Insulin Signaling
    Insulin Signaling


    Find genes that share SuperPaths with MAP4K3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP4K3
        JNK Pathway
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP4K3
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for MAP4K3
        Signal transduction JNK pathway

    3 BioSystems Pathways for MAP4K3
        MAPK signaling pathway
    Insulin Signaling
    TNF receptor signaling pathway


    1 Kegg Pathway  (Kegg details for MAP4K3):
        MAPK signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAP4K3
    Interactions:

        GeneGlobe Interaction Network for MAP4K3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for MAP4K3 (Q8IVH81, 3 ENSP000002638814) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 3, ENSP000003390074EBI-1758170,EBI-401755 I2D: score=4 STRING: ENSP00000339007
    SORBS1Q9BX663, ENSP000003551364I2D: score=3 STRING: ENSP00000360272 STRING: ENSP00000355136
    COPS5Q929053, ENSP000003505124I2D: score=3 STRING: ENSP00000350512
    BIN1O004993, ENSP000003167794I2D: score=1 STRING: ENSP00000316779
    SH3GL2Q999623, ENSP000003699814I2D: score=2 STRING: ENSP00000369981
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000185activation of MAPKKK activity IBA--
    GO:0006468protein phosphorylation IDA9275185
    GO:0007254JNK cascade TAS9275185
    GO:0009411response to UV IDA9275185
    GO:0034612response to tumor necrosis factor IDA9275185

    Find genes that share ontologies with MAP4K3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP4K3 (M4K3)

    3 HMDB Compounds for MAP4K3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for MAP4K3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 50.6 2 9820741 (1), 10979967 (1)
    serine 37.7 2 9820741 (1), 10979967 (1)



    Find genes that share compounds with MAP4K3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MAP4K3 gene (2 alternative transcripts): 
    NM_001270425.1  NM_003618.3  

    Unigene Cluster for MAP4K3:

    Mitogen-activated protein kinase kinase kinase kinase 3
    Hs.655750  [show with all ESTs]
    Unigene Representative Sequence: NM_003618
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263881(uc010yns.2 uc002rro.3 uc002rrp.3) ENST00000437545
    ENST00000341681 ENST00000479708 ENST00000475457 ENST00000495648 ENST00000497566
    ENST00000474502 ENST00000465701 ENST00000414968 ENST00000429397 ENST00000437968
    ENST00000484274 ENST00000536018
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAP4K3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP4K3 (see all 44):
    hsa-miR-21* hsa-let-7d hsa-miR-429 hsa-let-7a-2* hsa-let-7g hsa-let-7a hsa-miR-200b hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidMAP4K3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAP4K3
    Predesigned siRNA for gene silencing in human, mouse, rat MAP4K3
    Clone
    Products:
         
    OriGene clones in human, mouse for MAP4K3 (see all 8)
    OriGene ORF clones in mouse, rat for MAP4K3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP4K3 (NM_003618)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP4K3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K3
    Addgene plasmids for MAP4K3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP4K3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MAP4K3
      QuantiTect SYBR Green Assays in human, mouse, rat MAP4K3
      QuantiFast Probe-based Assays in human, mouse, rat MAP4K3

    Additional mRNA sequence: 

    AK021553.1 AK291467.1 AK299889.1 AK314487.1 AK316144.1 BC060880.1 BC071579.1 

    18 DOTS entries:

    DT.92002754  DT.70104021  DT.100650188  DT.120962589  DT.120962500  DT.40108322  DT.95155821  DT.100755411 
    DT.116209  DT.120962675  DT.207519  DT.75112927  DT.75129923  DT.91935214  DT.92427062  DT.92427066 
    DT.95290103  DT.120962704 

    Selected AceView cDNA sequences (see all 110):

    AI918730 NM_003618 BX506982 AA741136 AA844713 BM786598 BM828868 AK021553 
    CA446177 AU117665 BX955753 AL704985 BU853305 AA258988 BU172549 AA258167 
    AI656125 BU854352 BQ023958 AU140006 BG428215 CB993103 BQ023990 AA453226 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                            -                                                               
    SP3:                                -     -     -     -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 26a · 26b ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
    SP1:        -     -                 -                                             
    SP2:        -     -                 -                                             
    SP3:                                                                              
    SP4:                                -                                             
    SP5:                                                                              


    ECgene alternative splicing isoforms for MAP4K3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MAP4K3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTTAACA
    MAP4K3 Expression
    About this image


    MAP4K3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    MAP4K3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP4K3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655750

    UniProtKB/Swiss-Prot: M4K3_HUMAN, Q8IVH8
    Tissue specificity: Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta,
    skeletal muscle, kidney and pancreas and lower levels in lung and liver

        Custom PCR Arrays for MAP4K3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP4K3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MAP4K3
    QuantiTect SYBR Green Assays in human, mouse, rat MAP4K3
    QuantiFast Probe-based Assays in human, mouse, rat MAP4K3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP4K3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map4k31 , 5 mitogen-activated protein kinase kinase kinase kinase more1, 5 88.96(n)1
    95.97(a)1
      17 (50.97 cM)5
    2250281  NM_001081357.11  NP_001074826.11 
     805805125 
    chicken
    (Gallus gallus)
    Aves MAP4K31 mitogen-activated protein kinase kinase kinase kinase more 83.77(n)
    90.53(a)
      425965  XM_003640932.2  XP_003640980.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAP4K36
    mitogen-activated protein kinase kinase kinase kin...
    92(a)
    1 ↔ 1
    1(253798501-253863498)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia map4k31 mitogen-activated protein kinase kinase kinase kinase more 79.61(n)
    90.95(a)
      100170570  NM_001130347.1  NP_001123819.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map4k3b1 mitogen-activated protein kinase kinase kinase kinase more 71.59(n)
    78.9(a)
      100005183  XM_001921600.3  XP_001921635.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70973
    hppy1
    protein amino acid phosphorylation
    receptor signaling more3
    happyhour1
    75(a)3
    58.74(n)1
    65.05(a)1
      372031  NM_137555.21  NP_611399.21 
    worm
    (Caenorhabditis elegans)
    Secernentea gck-21 gck-2 54.92(n)
    49.07(a)
      179072  NM_072320.4  NP_504721.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIC16
    Protein kinase of the PAK/Ste20 family, required f...
    21(a)
    1 → many
    VIII(316572-319814) YHR102W


    ENSEMBL Gene Tree for MAP4K3 (if available)
    TreeFam Gene Tree for MAP4K3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MAP4K3 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    Selected SIMAP similar genes for MAP4K3 using alignment to 8 protein entries:     M4K3_HUMAN (see all proteins) (see all similar genes):
    MAP4K5    CDK2    MAP4K2    PNCK    TNIK    MYO3A
    MAP4K1    MAP4K4    STK25    CDK1    STK24    PAK2
    STK3    PAK1    DKFZp686J1430    PAK4    STK4    MST4

    Find genes that share paralogs with MAP4K3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MAP4K3 (see all 4041)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407454
    A lung squamous cell carcinoma sample4--see VAR_0407452 T S mis40--------
    rs2005726241,2
    C--39225366(-) AAAAAA/CCAATT 2 -- int10--------
    rs1824405501,2
    --39347185(+) CAATGC/GTTCCT 2 -- ds50010--------
    rs1862773631,2
    --39347197(+) ACTTTC/TTCTAA 2 -- ds50010--------
    rs1915235581,2
    --39347285(+) AGAAGC/GCACTC 2 -- ds50010--------
    rs101956291,2
    C,F,A--39347332(+) CATGTA/GAGTGA 2 -- ds500112Minor allele frequency- G:0.23NA WA CSA EA 378
    rs739248101,2
    C,F--39347407(+) GAGGAC/ATGTAG 2 -- ds50013Minor allele frequency- A:0.06WA NA 240
    rs743423811,2
    C,F--39347483(+) GTTTCT/CGCAAA 2 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1833165181,2
    --39347671(+) GACAAA/GCTACT 2 -- ds50010--------
    rs794172631,2
    C,F--39347685(+) CAACAG/ACATGT 2 -- ut311Minor allele frequency- A:0.07EA 120

    HapMap Linkage Disequilibrium report for MAP4K3 (39476407 - 39664453 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAP4K3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677029CNV Deletion23128226
    esv2442819CNV Deletion19546169
    esv2582384CNV Deletion19546169
    nsv2694CNV Insertion18451855
    nsv873885CNV Loss21882294
    nsv2693CNV Loss18451855
    nsv873888CNV Loss21882294
    nsv833847CNV Loss17160897
    dgv4091n71CNV Loss21882294
    nsv2695CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MAP4K3
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP4K3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604921    OMIM disorders: --


    Find genes that share disorders with MAP4K3           About GenesLikeMe

    Genetic Association Database (GAD): MAP4K3
    Human Genome Epidemiology (HuGE) Navigator: MAP4K3 (6 documents)

    Export disorders for MAP4K3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MAP4K3 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with MAP4K3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. (PubMed id 9275185)1, 2, 3, 9 Diener K.... Yao Z. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3. (PubMed id 23981581)1 Zhao B....Yang Y. (Cancer Lett. 2014)
    5. Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism. (PubMed id 22898570)1 Schriever S.C....Ensenauer R. (J. Nutr. Biochem. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    8. Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker. (PubMed id 22867055)1 Chen D.Y....Tan T.H. (BMC Med 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (Nat. Biotechnol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8491 HGNC: 6865 AceView: MAP4K3 Ensembl:ENSG00000011566 euGenes: HUgn8491
    ECgene: MAP4K3 Kegg: 8491 H-InvDB: MAP4K3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MAP4K3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP4K3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MAP4K3 gene:
    Search GeneIP for patents involving MAP4K3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MAP4K3   OriGene RNAi products in human, mouse, rat for MAP4K3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MAP4K3  
     OriGene MassSpec for MAP4K3   OriGene clones in human, mouse for MAP4K3  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAP4K3   OriGene Purified Protein for MAP4K3  
     OriGene ORF clones in mouse, rat for MAP4K3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAP4K3   OriGene Custom Protein Services for MAP4K3  

     
     
     Block miRNA regulation of human, mouse, rat MAP4K3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MAP4K3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP4K3 Predesigned siRNA for gene silencing in human, mouse, rat MAP4K3
     QuantiFast Probe-based Assays in human, mouse, rat MAP4K3 QuantiTect SYBR Green Assays in human, mouse, rat MAP4K3
     Custom PCR Arrays for MAP4K3 Search Chromatin IP Primers for MAP4K3
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MAP4K3  GeneGlobe Interaction Network for MAP4K3
     Regulatory tfbs in MAP4K3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MAP4K3 GenScript cDNA clones with any tag delivered in your preferred vector for MAP4K3
     GenScript Custom Assay Services for MAP4K3 GenScript Custom overexpressing Cell Line Services for MAP4K3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for MAP4K3  (KHS2)

     Search Tocris compounds for MAP4K3 (M4K3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MAP4K3 antibodies
     MAP4K3 lysates
     Antibodies for MAP4K3
     See all of Abcam's Antibodies, Kits and Proteins for MAP4K3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MAP4K3
     Antibodies for MAP4K3
     ELISAs for MAP4K3
     CLIAs for MAP4K3



     Browse ESI BIO Cell Lines and PureStem Progenitors for MAP4K3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K3
     SwitchGear 3'UTR luciferase reporter plasmids for MAP4K3
     SwitchGear Promoter luciferase reporter plasmids for MAP4K3
     ThermoFisher Antibody for MAP4K3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K3
     Browse compounds at ApexBio
     Addgene plasmids for MAP4K3
      Search eBioscience for proteins for MAP4K3
      Search eBioscience for elisas for MAP4K3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for MAP4K3
     antibodies-online antibodies for MAP4K3 (3 products)
     antibodies-online kits for MAP4K3 (6 products)
     antibodies-online peptides for MAP4K3
      Search antibodies-online for proteins for MAP4K3
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAP4K3 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4