Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAP4K3 Gene

Aliases for MAP4K3 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 2 3 5
  • Germinal Center Kinase-Related Protein Kinase 3 4
  • MAPK/ERK Kinase Kinase Kinase 3 3 4
  • MEK Kinase Kinase 3 3 4
  • EC 2.7.11.1 4 61
  • RAB8IPL1 3 4
  • MEKKK 3 3 4
  • GLK 3 4
  • Germinal Center Kinase-Like Kinase 3
  • EC 2.7.11 61
  • MAPKKKK3 3
  • MEKKK3 3

External Ids for MAP4K3 Gene

Previous HGNC Symbols for MAP4K3 Gene

  • RAB8IPL1

Previous GeneCards Identifiers for MAP4K3 Gene

  • GC02M039440
  • GC02M039623
  • GC02M039450
  • GC02M039388
  • GC02M039329
  • GC02M039476

Summaries for MAP4K3 Gene

Entrez Gene Summary for MAP4K3 Gene

  • This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MAP4K3 Gene

MAP4K3 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3) is a Protein Coding gene. Among its related pathways are TNF signaling (REACTOME) and MAPK signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K5.

UniProtKB/Swiss-Prot for MAP4K3 Gene

  • May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP4K3 Gene

Genomics for MAP4K3 Gene

Regulatory Elements for MAP4K3 Gene

Enhancers for MAP4K3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F039503 1.1 FANTOM5 Ensembl ENCODE 4.6 -68.0 -67952 4.1 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 SP5 ZHX2 MIER2 REST LOC728730 TMEM178A MAP4K3 DHX57 PIR40288
GH02F039491 1.5 FANTOM5 Ensembl ENCODE 4.4 -56.3 -56289 5.2 PKNOX1 SIN3A FEZF1 YY1 SLC30A9 CBX5 ZNF207 FOS SP5 JUNB LOC728730 MAP4K3 PIR40288
GH02F039538 0.3 FANTOM5 3.5 -101.7 -101693 0.1 MAP4K3 PIR40288
GH02F039126 1.1 FANTOM5 Ensembl ENCODE 3.1 +308.8 308797 3.4 PKNOX1 TBL1XR1 CEBPG EBF1 ZBTB40 RELA MAFK SRF TEAD1 MTA2 SOS1 MAP4K3 ENSG00000202309 GC02M039129
GH02F039434 1.2 FANTOM5 ENCODE 0.8 -0.3 -320 5.6 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 FOS KLF13 PAF1 SOS1 LOC728730 DHX57 MAP4K3 PIR40288
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MAP4K3 on UCSC Golden Path with GeneCards custom track

Promoters for MAP4K3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000588602 512 4401 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 KLF13 PAF1 ZNF263

Genomic Location for MAP4K3 Gene

Chromosome:
2
Start:
39,249,266 bp from pter
End:
39,437,312 bp from pter
Size:
188,047 bases
Orientation:
Minus strand

Genomic View for MAP4K3 Gene

Genes around MAP4K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP4K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP4K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4K3 Gene

Proteins for MAP4K3 Gene

  • Protein details for MAP4K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVH8-M4K3_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase kinase 3
    Protein Accession:
    Q8IVH8
    Secondary Accessions:
    • Q6IQ39
    • Q8IVH7
    • Q9UDM5
    • Q9Y6R5

    Protein attributes for MAP4K3 Gene

    Size:
    894 amino acids
    Molecular mass:
    101316 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation (By similarity).

    Alternative splice isoforms for MAP4K3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP4K3 Gene

Post-translational modifications for MAP4K3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP4K3 (KHS2)
  • Abcam antibodies for MAP4K3
  • Santa Cruz Biotechnology (SCBT) Antibodies for MAP4K3

Domains & Families for MAP4K3 Gene

Protein Domains for MAP4K3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVH8

UniProtKB/Swiss-Prot:

M4K3_HUMAN :
  • Contains 1 CNH domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 CNH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP4K3: view

Function for MAP4K3 Gene

Molecular function for MAP4K3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Enzyme Numbers (IUBMB) for MAP4K3 Gene

Gene Ontology (GO) - Molecular Function for MAP4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS 9275185
GO:0004674 protein serine/threonine kinase activity IEA,IDA 9275185
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with MAP4K3: view
genes like me logo Genes that share phenotypes with MAP4K3: view

Animal Model Products

miRNA for MAP4K3 Gene

miRTarBase miRNAs that target MAP4K3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP4K3 Gene

Localization for MAP4K3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP4K3 Gene COMPARTMENTS Subcellular localization image for MAP4K3 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MAP4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MAP4K3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP4K3 Gene

Pathways & Interactions for MAP4K3 Gene

genes like me logo Genes that share pathways with MAP4K3: view

Pathways by source for MAP4K3 Gene

1 Cell Signaling Technology pathway for MAP4K3 Gene
1 KEGG pathway for MAP4K3 Gene
1 GeneGo (Thomson Reuters) pathway for MAP4K3 Gene
2 Qiagen pathways for MAP4K3 Gene

SIGNOR curated interactions for MAP4K3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IEA --
GO:0006468 protein phosphorylation IEA,IDA 9275185
GO:0007254 JNK cascade TAS 9275185
GO:0009411 response to UV IDA 9275185
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP4K3: view

Drugs & Compounds for MAP4K3 Gene

(4) Drugs for MAP4K3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for MAP4K3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAP4K3: view

Transcripts for MAP4K3 Gene

Unigene Clusters for MAP4K3 Gene

Mitogen-activated protein kinase kinase kinase kinase 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1:
SP2: -
SP3: - - - -
SP4:
SP5:
SP6:

ExUns: 26a · 26b ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for MAP4K3 Gene

GeneLoc Exon Structure for
MAP4K3
ECgene alternative splicing isoforms for
MAP4K3

Expression for MAP4K3 Gene

mRNA expression in normal human tissues for MAP4K3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP4K3 Gene

This gene is overexpressed in Placenta (19.7), Testis (10.6), Frontal cortex (10.5), and Pancreas (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP4K3 Gene



Protein tissue co-expression partners for MAP4K3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP4K3 Gene:

MAP4K3

SOURCE GeneReport for Unigene cluster for MAP4K3 Gene:

Hs.655750

mRNA Expression by UniProt/SwissProt for MAP4K3 Gene:

Q8IVH8-M4K3_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.
genes like me logo Genes that share expression patterns with MAP4K3: view

Primer Products

No data available for mRNA differential expression in normal tissues for MAP4K3 Gene

Orthologs for MAP4K3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP4K3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP4K3 34 35
  • 99.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAP4K3 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP4K3 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP4K3 34 35
  • 94.89 (n)
cow
(Bos Taurus)
Mammalia MAP4K3 34 35
  • 94.15 (n)
mouse
(Mus musculus)
Mammalia Map4k3 34 16 35
  • 88.96 (n)
rat
(Rattus norvegicus)
Mammalia Map4k3 34
  • 87.78 (n)
chicken
(Gallus gallus)
Aves MAP4K3 34 35
  • 83.77 (n)
lizard
(Anolis carolinensis)
Reptilia MAP4K3 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map4k3 34
  • 79.61 (n)
zebrafish
(Danio rerio)
Actinopterygii MAP4K3 (2 of 2) 35
  • 80 (a)
OneToMany
map4k3b 34 35
  • 71.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7097 36
  • 75 (a)
hppy 34 35
  • 58.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010837 34
  • 42.51 (n)
worm
(Caenorhabditis elegans)
Secernentea gck-2 34 35
  • 54.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIC1 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2532 34
Species where no ortholog for MAP4K3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP4K3 Gene

ENSEMBL:
Gene Tree for MAP4K3 (if available)
TreeFam:
Gene Tree for MAP4K3 (if available)

Paralogs for MAP4K3 Gene

Variants for MAP4K3 Gene

Sequence variations from dbSNP and Humsavar for MAP4K3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_040745 A lung squamous cell carcinoma sample
rs1012689 -- 39,322,246(+) AAACA(A/G)AAACA intron-variant
rs10153665 -- 39,272,926(+) AGGCA(C/T)AATAT intron-variant
rs10166302 -- 39,364,655(+) ctgag(A/G)ccagg intron-variant
rs10166473 -- 39,290,911(+) atctc(C/T)actaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP4K3 Gene

Variant ID Type Subtype PubMed ID
dgv6792n54 CNV gain 21841781
esv2442819 CNV deletion 19546169
esv2582384 CNV deletion 19546169
esv2677029 CNV deletion 23128226
esv2762497 CNV loss 21179565
esv3590429 CNV loss 21293372
esv6749 CNV gain 19470904
nsv2693 CNV deletion 18451855
nsv2694 CNV insertion 18451855
nsv2695 CNV deletion 18451855
nsv833847 CNV loss 17160897
nsv997934 CNV gain 25217958

Variation tolerance for MAP4K3 Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP4K3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP4K3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4K3 Gene

Disorders for MAP4K3 Gene

Relevant External Links for MAP4K3

Genetic Association Database (GAD)
MAP4K3
Human Genome Epidemiology (HuGE) Navigator
MAP4K3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP4K3

No disorders were found for MAP4K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP4K3 Gene

Publications for MAP4K3 Gene

  1. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. (PMID: 9275185) Diener K. … Yao Z. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for MAP4K3 Gene

Sources for MAP4K3 Gene

Content
Loading form....