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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP4K3 Gene

protein-coding   GIFtS: 64
GCID: GC02M039476

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3


(Previous symbol: RAB8IPL1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 31 2     MEKKK 32 3
RAB8IPL11 2 3     EC 2.7.11.13 8
Germinal Center Kinase-Related Protein Kinase2 3     MAPKKKK32
GLK2 3     MEKKK32
MAPK/ERK Kinase Kinase Kinase 32 3     Germinal Center Kinase-Like Kinase2
MEK Kinase Kinase 32 3     EC 2.7.118

External Ids:    HGNC: 68651   Entrez Gene: 84912   Ensembl: ENSG000000115667   OMIM: 6049215   UniProtKB: Q8IVH83   

Export aliases for MAP4K3 gene to outside databases

Previous GC identifers: GC02M039440 GC02M039623 GC02M039450 GC02M039388 GC02M039329 GC02M039215


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP4K3 Gene:
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded
protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding
multiple isoforms have been observed for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for MAP4K3 Gene: 
MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3) is a protein-coding gene. Diseases associated with MAP4K3 include lung cancer, and among its related super-pathways are MAPK signaling pathway and MAPK Family Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and small GTPase regulator activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: M4K3_HUMAN, Q8IVH8
Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal
pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP4K3 gene promoter:
         SRF   AML1a   SRF (504 AA)   HTF   CUTL1   RORalpha1   PPAR-alpha   HSF2   Msx-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP4K3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP4K3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP4K3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.3

MAP4K3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4K3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M039476:  view genomic region     (about GC identifiers)

Start:
39,476,407 bp from pter      End:
39,664,453 bp from pter
Size:
188,047 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M4K3_HUMAN, Q8IVH8 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 3  
Size: 894 amino acids; 101316 Da
Cofactor: Magnesium
Subunit: Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation (By similarity)
Secondary accessions: Q6IQ39 Q8IVH7 Q9UDM5 Q9Y6R5
Alternative splicing: 3 isoforms:  Q8IVH8-1   Q8IVH8-2   Q8IVH8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP4K3: NX_Q8IVH8

Explore proteomics data for MAP4K3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IVH8

  • 4/25 DME Specific Peptides for MAP4K3 (Q8IVH8) (see all 25)
     QLYSHNL  LFLMTKS  PKKRPTA  GITAIEL 

    MAP4K3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP4K3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001257354.1  NP_003609.2  

    ENSEMBL proteins: 
     ENSP00000263881   ENSP00000416958   ENSP00000345434   ENSP00000399228   ENSP00000405137  
     ENSP00000410183   ENSP00000440580  

    Human Recombinant Protein Products for MAP4K3: 
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    Novus Biologicals MAP4K3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP4K3 


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    Abcam antibodies for MAP4K3
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    ThermoFisher Antibody for MAP4K3
    LSBio Antibodies in human, mouse, rat for MAP4K3 

    Assay Products for MAP4K3: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP4K3 
    Cloud-Clone Corp. CLIAs for MAP4K3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAP4K: Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase kinase 3 
    KHS subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR001180 Citron

    Graphical View of Domain Structure for InterPro Entry Q8IVH8

    ProtoNet protein and cluster: Q8IVH8

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: M4K3_HUMAN, Q8IVH8
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    MAP4K3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M4K3_HUMAN, Q8IVH8
    Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal
    pathway
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9275185
    GO:0004674protein serine/threonine kinase activity IDA9275185
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding IPI17474147
         
    MAP4K3 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAP4K3:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death in HCT116  Increased mitotic index 
     Increased telomerase activity 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Map4k3):
     cellular  hematopoietic system  immune system 

    MAP4K3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP4K3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP4K3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP4K3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP4K3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP4K3
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP4K3 (see all 44):
    hsa-miR-21* hsa-let-7d hsa-miR-429 hsa-let-7a-2* hsa-let-7g hsa-let-7a hsa-miR-200b hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidMAP4K3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAP4K3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51
    3Signal transduction JNK pathway
    Signal transduction JNK pathway0.98
    4TNF receptor signaling pathway
    TNF receptor signaling pathway
    5Insulin Signaling
    Insulin Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MAP4K3
        Signal transduction JNK pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP4K3
        JNK Pathway
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP4K3
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for MAP4K3
        Signal transduction JNK pathway

    3 BioSystems Pathways for MAP4K3
        MAPK signaling pathway
    Insulin Signaling
    TNF receptor signaling pathway


    1         Kegg Pathway  (Kegg details for MAP4K3):
        MAPK signaling pathway


    MAP4K3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP4K3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/26 Interacting proteins for MAP4K3 (Q8IVH81, 3 ENSP000002638814) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 3, ENSP000003390074EBI-1758170,EBI-401755 I2D: score=4 STRING: ENSP00000339007
    SORBS1Q9BX663, ENSP000003551364I2D: score=3 STRING: ENSP00000360272 STRING: ENSP00000355136
    COPS5Q929053, ENSP000003505124I2D: score=3 STRING: ENSP00000350512
    BIN1O004993, ENSP000003167794I2D: score=1 STRING: ENSP00000316779
    SH3GL2Q999623, ENSP000003699814I2D: score=2 STRING: ENSP00000369981
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA9275185
    GO:0006950response to stress ----
    GO:0007243intracellular protein kinase cascade IDA9275185
    GO:0007254JNK cascade TAS9275185
    GO:0009411response to UV IDA9275185

    MAP4K3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP4K3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP4K3 (M4K3)

    3 HMDB Compounds for MAP4K3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for MAP4K3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 50.6 2 9820741 (1), 10979967 (1)
    serine 37.7 2 9820741 (1), 10979967 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP4K3 / M4K3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP4K3 gene (2 alternative transcripts): 
    NM_001270425.1  NM_003618.3  

    Unigene Cluster for MAP4K3:

    Mitogen-activated protein kinase kinase kinase kinase 3
    Hs.655750  [show with all ESTs]
    Unigene Representative Sequence: NM_003618
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263881(uc010yns.2 uc002rro.3 uc002rrp.3) ENST00000437545
    ENST00000341681 ENST00000479708 ENST00000475457 ENST00000495648 ENST00000497566
    ENST00000474502 ENST00000465701 ENST00000414968 ENST00000429397 ENST00000437968
    ENST00000484274 ENST00000536018
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP4K3
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP4K3 (see all 44):
    hsa-miR-21* hsa-let-7d hsa-miR-429 hsa-let-7a-2* hsa-let-7g hsa-let-7a hsa-miR-200b hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidMAP4K3 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K3
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP4K3

    Additional mRNA sequence: 

    AK021553.1 AK291467.1 AK299889.1 AK314487.1 AK316144.1 BC060880.1 BC071579.1 

    18 DOTS entries:

    DT.92002754  DT.70104021  DT.100650188  DT.120962589  DT.120962500  DT.40108322  DT.95155821  DT.100755411 
    DT.116209  DT.120962675  DT.207519  DT.75112927  DT.75129923  DT.91935214  DT.92427062  DT.92427066 
    DT.95290103  DT.120962704 

    24/110 AceView cDNA sequences (see all 110):

    BM786598 BM828868 AK021553 BX506982 AA844713 AI918730 BX955753 AU117665 
    NM_003618 CA446177 AA741136 AU140006 BX502183 CB993103 AL044050 AI656125 
    BU852924 AW965021 BG104801 AI208702 R25175 BM785864 AA250885 AA250828 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                            -                                                               
    SP3:                                -     -     -     -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 26a · 26b ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
    SP1:        -     -                 -                                             
    SP2:        -     -                 -                                             
    SP3:                                                                              
    SP4:                                -                                             
    SP5:                                                                              


    ECgene alternative splicing isoforms for MAP4K3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP4K3 expression in normal human tissues (normalized intensities)      MAP4K3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTTAACA
    MAP4K3 Expression
    About this image


    MAP4K3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             ganglion/cranial   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See MAP4K3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP4K3

    SOURCE GeneReport for Unigene cluster: Hs.655750

    UniProtKB/Swiss-Prot: M4K3_HUMAN, Q8IVH8
    Tissue specificity: Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta,
    skeletal muscle, kidney and pancreas and lower levels in lung and liver

        SABiosciences Custom PCR Arrays for MAP4K3
    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAP4K3 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map4k31 , 5 mitogen-activated protein kinase kinase kinase kinase more1, 5 88.96(n)1
    95.97(a)1
      17 (50.97 cM)5
    2250281  NM_001081357.11  NP_001074826.11 
     805805125 
    chicken
    (Gallus gallus)
    Aves MAP4K31 mitogen-activated protein kinase kinase kinase kinase more 84.79(n)
    92.07(a)
      425965  XM_003640932.1  XP_003640980.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAP4K36
    Mitogen-activated protein kinase kinase kinase kin...
    92(a)
    1 ↔ 1
    1(253798501-253863498)
    zebrafish
    (Danio rerio)
    Actinopterygii map4k31 mitogen-activated protein kinase kinase kinase kinase more 71.56(n)
    78.06(a)
      100005183  XM_001921600.2  XP_001921635.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70973
    hppy1
    protein amino acid phosphorylation
    receptor signaling more3
    happyhour1
    75(a)3
    58.74(n)1
    65.05(a)1
      372031  NM_137555.21  NP_611399.21 
    worm
    (Caenorhabditis elegans)
    Secernentea gck-21 Protein GCK-2 54.4(n)
    47.88(a)
      179072  NM_072320.3  NP_504721.1 


    ENSEMBL Gene Tree for MAP4K3 (if available)
    TreeFam Gene Tree for MAP4K3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP4K3 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    18/48 SIMAP similar genes for MAP4K3 using alignment to 7 protein entries:     M4K3_HUMAN (see all proteins) (see all similar genes):
    MAP4K5    CDK2    MAP4K2    PNCK    TNIK    MYO3A
    MAP4K1    MAP4K4    STK25    CDK1    STK24    PAK2
    STK3    PAK1    DKFZp686J1430    PAK4    STK4    MST4

    MAP4K3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4041 SNPs in MAP4K3 are shown (see all 4041)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407454
    A lung squamous cell carcinoma sample4--see VAR_0407452 T S mis40--------
    rs2005726241,2
    C--39225366(-) AAAAAA/CCAATT 2 -- int10--------
    rs1824405501,2
    --39347185(+) CAATGC/GTTCCT 2 -- ds50010--------
    rs1862773631,2
    --39347197(+) ACTTTC/TTCTAA 2 -- ds50010--------
    rs1915235581,2
    --39347285(+) AGAAGC/GCACTC 2 -- ds50010--------
    rs101956291,2
    C,F,A--39347332(+) CATGTA/GAGTGA 2 -- ds500112Minor allele frequency- G:0.23NA WA CSA EA 378
    rs739248101,2
    C,F--39347407(+) GAGGAC/ATGTAG 2 -- ds50013Minor allele frequency- A:0.06WA NA 240
    rs743423811,2
    C,F--39347483(+) GTTTCT/CGCAAA 2 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1833165181,2
    --39347671(+) GACAAA/GCTACT 2 -- ds50010--------
    rs794172631,2
    C,F--39347685(+) CAACAG/ACATGT 2 -- ut311Minor allele frequency- A:0.07EA 120

    HapMap Linkage Disequilibrium report for MAP4K3 (39476407 - 39664453 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for MAP4K3 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677029CNV Deletion23128226
    esv2442819CNV Deletion19546169
    esv2582384CNV Deletion19546169
    nsv2694CNV Insertion18451855
    nsv873885CNV Loss21882294
    nsv2693CNV Loss18451855
    nsv873888CNV Loss21882294
    nsv833847CNV Loss17160897
    dgv4091n71CNV Loss21882294
    nsv2695CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604921    OMIM disorders: --

    2 diseases for MAP4K3:    About MalaCards
    lung cancer    


    MAP4K3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAP4K3
    Human Genome Epidemiology (HuGE) Navigator: MAP4K3 (6 documents)

    Export disorders for MAP4K3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP4K3 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with MAP4K3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. (PubMed id 9275185)1, 2, 3, 9 Diener K.... Yao Z. (1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Germinal center kinase-like kinase (GLK/MAP4K3) expres sion is increased in adult-onset Still's disease and may act as an activity mark er. (PubMed id 22867055)1 Chen D.Y....Tan T.H. (2012)
    5. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (2011)
    6. The kinase GLK controls autoimmunity and NF-I_B signal ing by activating the kinase PKC-I, in T cells. (PubMed id 21983831)1 Chuang H.C....Tan T.H. (2011)
    7. PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrien t signaling to mTOR. (PubMed id 20227368)1 Yan L....Lamb R.F. (2010)
    8. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    9. Replication of previous genome-wide association studi es of bone mineral density in premenopausal American women. (PubMed id 20200978)1 Ichikawa S....Econs M.J. (2010)
    10. MAP4K3 modulates cell death via the post-transcriptio nal regulation of BH3-only proteins. (PubMed id 19587239)1 Lam D....Martins L.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8491 HGNC: 6865 AceView: MAP4K3 Ensembl:ENSG00000011566 euGenes: HUgn8491
    ECgene: MAP4K3 Kegg: 8491 H-InvDB: MAP4K3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP4K3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP4K3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP4K3 gene:
    Search GeneIP for patents involving MAP4K3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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