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Aliases for MAP4K3 Gene

Aliases for MAP4K3 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 2 3
  • Germinal Center Kinase-Related Protein Kinase 3 4
  • MAPK/ERK Kinase Kinase Kinase 3 3 4
  • MEK Kinase Kinase 3 3 4
  • EC 2.7.11.1 4 63
  • RAB8IPL1 3 4
  • MEKKK 3 3 4
  • GLK 3 4
  • Germinal Center Kinase-Like Kinase 3
  • EC 2.7.11 63
  • MAPKKKK3 3
  • MEKKK3 3

External Ids for MAP4K3 Gene

Previous HGNC Symbols for MAP4K3 Gene

  • RAB8IPL1

Previous GeneCards Identifiers for MAP4K3 Gene

  • GC02M039440
  • GC02M039623
  • GC02M039450
  • GC02M039388
  • GC02M039329
  • GC02M039476

Summaries for MAP4K3 Gene

Entrez Gene Summary for MAP4K3 Gene

  • This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MAP4K3 Gene

MAP4K3 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is STK10.

UniProtKB/Swiss-Prot for MAP4K3 Gene

  • May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP4K3 Gene

Genomics for MAP4K3 Gene

Regulatory Elements for MAP4K3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAP4K3 Gene

Start:
39,249,266 bp from pter
End:
39,437,312 bp from pter
Size:
188,047 bases
Orientation:
Minus strand

Genomic View for MAP4K3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP4K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4K3 Gene

Proteins for MAP4K3 Gene

  • Protein details for MAP4K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVH8-M4K3_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase kinase 3
    Protein Accession:
    Q8IVH8
    Secondary Accessions:
    • Q6IQ39
    • Q8IVH7
    • Q9UDM5
    • Q9Y6R5

    Protein attributes for MAP4K3 Gene

    Size:
    894 amino acids
    Molecular mass:
    101316 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation (By similarity).

    Alternative splice isoforms for MAP4K3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP4K3 Gene

Proteomics data for MAP4K3 Gene at MOPED

Post-translational modifications for MAP4K3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP4K3 (KHS2)

Domains for MAP4K3 Gene

Gene Families for MAP4K3 Gene

HGNC:
  • MAP4K :Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases
IUPHAR :

Protein Domains for MAP4K3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVH8

UniProtKB/Swiss-Prot:

M4K3_HUMAN :
  • Q8IVH8
Domain:
  • Contains 1 CNH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP4K3: view

Function for MAP4K3 Gene

Molecular function for MAP4K3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

Enzyme Numbers (IUBMB) for MAP4K3 Gene

Gene Ontology (GO) - Molecular Function for MAP4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9275185
GO:0004674 protein serine/threonine kinase activity IDA 9275185
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with MAP4K3: view
genes like me logo Genes that share phenotypes with MAP4K3: view

Animal Model Products

CRISPR Products

miRNA for MAP4K3 Gene

miRTarBase miRNAs that target MAP4K3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP4K3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MAP4K3 Gene

Localization for MAP4K3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP4K3 Gene COMPARTMENTS Subcellular localization image for MAP4K3 gene
Compartment Confidence
cytosol 3
cytoskeleton 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MAP4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MAP4K3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP4K3 Gene

Pathways for MAP4K3 Gene

genes like me logo Genes that share pathways with MAP4K3: view

Pathways by source for MAP4K3 Gene

2 Qiagen pathways for MAP4K3 Gene
1 Cell Signaling Technology pathway for MAP4K3 Gene
1 KEGG pathway for MAP4K3 Gene
1 GeneGo (Thomson Reuters) pathway for MAP4K3 Gene

Gene Ontology (GO) - Biological Process for MAP4K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 9275185
GO:0007254 JNK cascade TAS 9275185
GO:0008152 metabolic process --
GO:0009411 response to UV IDA 9275185
GO:0034612 response to tumor necrosis factor IDA 9275185
genes like me logo Genes that share ontologies with MAP4K3: view

Compounds for MAP4K3 Gene

(3) HMDB Compounds for MAP4K3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(2) Novoseek inferred chemical compound relationships for MAP4K3 Gene

Compound -log(P) Hits PubMed IDs
threonine 50.6 2
serine 37.7 2
genes like me logo Genes that share compounds with MAP4K3: view

Transcripts for MAP4K3 Gene

Unigene Clusters for MAP4K3 Gene

Mitogen-activated protein kinase kinase kinase kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP4K3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MAP4K3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1:
SP2: -
SP3: - - - -
SP4:
SP5:
SP6:

ExUns: 26a · 26b ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for MAP4K3 Gene

GeneLoc Exon Structure for
MAP4K3
ECgene alternative splicing isoforms for
MAP4K3

Expression for MAP4K3 Gene

mRNA expression in normal human tissues for MAP4K3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP4K3 Gene

SOURCE GeneReport for Unigene cluster for MAP4K3 Gene Hs.655750

mRNA Expression by UniProt/SwissProt for MAP4K3 Gene

Q8IVH8-M4K3_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.
genes like me logo Genes that share expressions with MAP4K3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAP4K3 Gene

Orthologs for MAP4K3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP4K3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP4K3 35
  • 99.66 (n)
  • 99.43 (a)
MAP4K3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP4K3 35
  • 94.15 (n)
  • 97.43 (a)
MAP4K3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP4K3 35
  • 94.89 (n)
  • 97.99 (a)
MAP4K3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map4k3 35
  • 88.96 (n)
  • 95.97 (a)
Map4k3 16
Map4k3 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP4K3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP4K3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map4k3 35
  • 87.78 (n)
  • 96.45 (a)
chicken
(Gallus gallus)
Aves MAP4K3 35
  • 83.77 (n)
  • 90.53 (a)
MAP4K3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP4K3 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map4k3 35
  • 79.61 (n)
  • 90.95 (a)
zebrafish
(Danio rerio)
Actinopterygii MAP4K3 (2 of 2) 36
  • 80 (a)
OneToMany
map4k3b 35
  • 71.59 (n)
  • 78.9 (a)
map4k3b 36
  • 74 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010837 35
  • 42.51 (n)
  • 34.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta hppy 35
  • 58.74 (n)
  • 65.05 (a)
hppy 36
  • 39 (a)
OneToMany
CG7097 37
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea gck-2 35
  • 54.92 (n)
  • 49.07 (a)
gck-2 36
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIC1 36
  • 21 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2532 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for MAP4K3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP4K3 Gene

ENSEMBL:
Gene Tree for MAP4K3 (if available)
TreeFam:
Gene Tree for MAP4K3 (if available)

Paralogs for MAP4K3 Gene

Paralogs for MAP4K3 Gene

genes like me logo Genes that share paralogs with MAP4K3: view

Variants for MAP4K3 Gene

Sequence variations from dbSNP and Humsavar for MAP4K3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8545 -- 39,356,305(-) ATTAT(C/T)ATGAT synonymous-codon, reference
rs9037 -- 39,249,341(-) TAATG(A/G)TAATG utr-variant-3-prime
rs759589 -- 39,286,554(-) TGATT(A/G)TTCAC intron-variant
rs809831 -- 39,428,990(-) cctct(C/T)gggtt intron-variant
rs1012689 -- 39,322,246(+) AAACA(A/G)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP4K3 Gene

Variant ID Type Subtype PubMed ID
nsv873885 CNV Loss 21882294
nsv833847 CNV Loss 17160897
esv2677029 CNV Deletion 23128226
nsv2693 CNV Loss 18451855
dgv4091n71 CNV Loss 21882294
nsv873888 CNV Loss 21882294
esv6749 CNV Gain 19470904
nsv2694 CNV Insertion 18451855
esv2582384 CNV Deletion 19546169
nsv2695 CNV Loss 18451855
esv2442819 CNV Deletion 19546169

Relevant External Links for MAP4K3 Gene

HapMap Linkage Disequilibrium report
MAP4K3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4K3 Gene

Disorders for MAP4K3 Gene

Relevant External Links for MAP4K3

Genetic Association Database (GAD)
MAP4K3
Human Genome Epidemiology (HuGE) Navigator
MAP4K3
genes like me logo Genes that share disorders with MAP4K3: view

No data available for UniProtKB/Swiss-Prot for MAP4K3 Gene

Publications for MAP4K3 Gene

  1. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. (PMID: 9275185) Diener K. … Yao Z. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3
  5. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PMID: 21706016) Bisson N. … Pawson T. (Nat. Biotechnol. 2011) 3

Products for MAP4K3 Gene

  • antibodies-online peptides for MAP4K3
  • antibodies-online antibodies for MAP4K3
  • antibodies-online kits for MAP4K3

Sources for MAP4K3 Gene

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