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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP4K2 Gene

protein-coding   GIFtS: 67
GCID: GC11M064556

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2


(Previous symbol: RAB8IP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 21 2     B Lymphocyte Serine/Threonine Protein Kinase2
RAB8IP1 2 3 5     Germinal Centre Kinase (GC Kinase)2
GCK2 3 5     Rab8 Interacting Protein2
MAPK/ERK Kinase Kinase Kinase 22 3     B Lymphocyte Serine/Threonine-Protein Kinase3
MEK Kinase Kinase 22 3     GC Kinase3
MEKKK 22 3     Germinal Center Kinase3
EC 2.7.11.13 8     Rab8-Interacting Protein3
BL442     EC 2.7.118

External Ids:    HGNC: 68641   Entrez Gene: 58712   Ensembl: ENSG000001680677   OMIM: 6031665   UniProtKB: Q128513   

Export aliases for MAP4K2 gene to outside databases

Previous GC identifers: GC11M067072 GC11M066238 GC11M064806 GC11M064331 GC11M064313 GC11M060883


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP4K2 Gene:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase
is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre,
where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown
to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2
(TRAF2), which is involved in the activation of MAP3K1/MEKK1. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP4K2 Gene: 
MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2) is a protein-coding gene. Diseases associated with MAP4K2 include anoxia, and gout, and among its related super-pathways are TNFR1 Pathway and MAPK Family Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: M4K2_HUMAN, Q12851
Function: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal
transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the
stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the
p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including
pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides
(LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also
stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling,
and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization,
which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation.
Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks
MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of
vesicle targeting or fusion

Gene Wiki entry for MAP4K2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP4K2 gene promoter:
         COUP-TF1   COUP-TF   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP4K2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP4K2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP4K2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

MAP4K2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4K2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M064556:  view genomic region     (about GC identifiers)

Start:
64,556,290 bp from pter      End:
64,570,713 bp from pter
Size:
14,424 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M4K2_HUMAN, Q12851 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 2  
Size: 820 amino acids; 91556 Da
Cofactor: Magnesium
Subunit: Interacts with TRAF2, TRAF6, MAP3K1/MEKK1 and MAP3K11/MLK3. Interacts with RAB8A (By similarity)
Subcellular location: Cytoplasm (By similarity). Basolateral cell membrane; Peripheral membrane protein (By
similarity). Golgi apparatus membrane; Peripheral membrane protein (By similarity)
Sequence caution: Sequence=AAA20968.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part;

Explore the universe of human proteins at neXtProt for MAP4K2: NX_Q12851

Explore proteomics data for MAP4K2 at MOPED 

Post-translational modifications:

  • UniProtKB: Polyubiquitinated through 'Lys-48'-polyubiquitin chains, allowing proteasomal turnover. Ubiquitination requires
    the kinase activity of MAP4K2/GCK
  • UniProtKB: Autophosphorylated in response to tumor necrosis factor (TNF), endotoxins or proinflammatory stimuli.
    Autophosphorylation leads to activation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12851

  • 4/9 DME Specific Peptides for MAP4K2 (Q12851) (see all 9)
     GITAIEL  VKLADFG  PKKRPTA  MEFCGGGS 

    MAP4K2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP4K2 Protein Expression
    REFSEQ proteins: NP_004570.2  
    ENSEMBL proteins: 
     ENSP00000400594   ENSP00000403410   ENSP00000294066   ENSP00000366567   ENSP00000413167  
     ENSP00000403563   ENSP00000404534  

    Human Recombinant Protein Products for MAP4K2: 
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    OriGene Protein Over-expression Lysate for MAP4K2
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    GenScript Custom Purified and Recombinant Proteins Services for MAP4K2
    Novus Biologicals MAP4K2 Protein
    Novus Biologicals MAP4K2 Lysates
    Sino Biological Recombinant Protein for MAP4K2
    Sino Biological Cell Lysate for MAP4K2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP4K2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016323basolateral plasma membrane IEA--

    MAP4K2 for ontologies           About GeneDecksing



    MAP4K2 Antibody Products: 
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    Abcam antibodies for MAP4K2
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    Cloud-Clone Corp. ELISAs for MAP4K2 
    Cloud-Clone Corp. CLIAs for MAP4K2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAP4K: Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase kinase 2 
    KHS subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR001180 Citron

    Graphical View of Domain Structure for InterPro Entry Q12851

    ProtoNet protein and cluster: Q12851

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: M4K2_HUMAN, Q12851
    Domain: The PEST domains are Pro-, Glu-, Ser-, and Thr-rich domains. Proteins with PEST domains are frequently
    targets of degradation by the ubiquitin proteasome
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    MAP4K2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M4K2_HUMAN, Q12851
    Function: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal
    transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the
    stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the
    p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including
    pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides
    (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also
    stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling,
    and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization,
    which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation.
    Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks
    MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of
    vesicle targeting or fusion
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: The tumor necrosis factor (TNF), as well as endotoxins and proinflammatory stimuli such as
    polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), peptidoglycan (PGN), flagellin, or lipid A
    activate MAP4K2 by promoting its autophosphorylation

         Genatlas biochemistry entry for MAP4K2:
    mitogen-activated kinase kinase kinase kinase 2,located in the MEN1 critical region

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA11784851
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding IPI11784851
         
    MAP4K2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAP4K2:
     Decreased substrate adherent c  Increased G2M DNA content, inc 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Map4k2):
     no phenotypic analysis 

    MAP4K2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Map4k2tm1Jmky for MAP4K2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP4K2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP4K2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP4K2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP4K2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP4K2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP4K2 (see all 18):
    hsa-miR-3678-3p hsa-miR-3673 hsa-miR-137 hsa-miR-25 hsa-miR-613 hsa-miR-3155b hsa-miR-92b hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidMAP4K2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MAP4K2 (NM_004579)
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                         Customized lentivirus expression plasmids for stable overexpression of MAP4K2 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAP4K2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TNFR1 Pathway0.56
    Apoptosis and survival TNFR1 signaling pathway0.52
    2TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51
    3Signal transduction JNK pathway
    Signal transduction JNK pathway0.98
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    5TRAF Pathway
    TRAF Pathway0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for MAP4K2
        Apoptosis and survival TNFR1 signaling pathway
    Signal transduction JNK pathway

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP4K2
        TRAF Pathway
    JNK Pathway
    MAPK Family Pathway
    TNFR1 Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP4K2
        MAP Kinase Signaling

    2 GeneGo (Thomson Reuters) Pathways for MAP4K2
        Signal transduction JNK pathway
    Apoptosis and survival TNFR1 signaling pathway

    2 BioSystems Pathways for MAP4K2
        Insulin Signaling
    TNF receptor signaling pathway



    1         Kegg Pathway  (Kegg details for MAP4K2):
        MAPK signaling pathway


    MAP4K2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP4K2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/18 Interacting proteins for MAP4K2 (Q128511, 2, 3 ENSP000002940664) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K1Q132331, 3, ENSP000003824234EBI-49783,EBI-49776 I2D: score=4 STRING: ENSP00000382423
    HNRNPA2B1P226262, 3, ENSP000003466944MINT-8260427 I2D: score=2 STRING: ENSP00000346694
    NACADO150692, 3MINT-8260438 I2D: score=2 
    PRDX4Q131622, 3MINT-8260449 I2D: score=2 
    SERPINA4P296222, 3MINT-8260460 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA11784851
    GO:0006903vesicle targeting NAS--
    GO:0006950response to stress TAS8643544
    GO:0006955immune response TAS7515885
    GO:0007243intracellular protein kinase cascade IDA11784851

    MAP4K2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP4K2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP4K2 (M4K2)

    3 HMDB Compounds for MAP4K2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    10 Novoseek inferred chemical compound relationships for MAP4K2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 78.1 36 18691424 (2), 8643544 (2), 9341881 (1), 12358757 (1) (see all 30)
    serine 68.8 32 18691424 (2), 8643544 (2), 12358757 (1), 16957890 (1) (see all 27)
    phosphatidylinositol 58 5 17073713 (1), 18187933 (1), 11287630 (1), 15138635 (1) (see all 5)
    rapamycin 24.8 1 16195541 (1)
    glycogen 24.5 3 9582355 (1), 10637513 (1), 11257494 (1)
    phosphoinositide 15.4 2 12358757 (1), 12244133 (1)
    lipid 0 1 12244133 (1)
    glucose 0 1 14749367 (1)
    calcium 0 4 19188511 (1)
    tyrosine 0 3 20182580 (1), 11287630 (1), 11782427 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP4K2 / M4K2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP4K2 gene: 
    NM_004579.3  

    Unigene Cluster for MAP4K2:

    Mitogen-activated protein kinase kinase kinase kinase 2
    Hs.534341  [show with all ESTs]
    Unigene Representative Sequence: NM_004579
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435926 ENST00000424945 ENST00000470088 ENST00000294066(uc001obh.3)
    ENST00000377350(uc001obi.3 uc010rnp.1) ENST00000433890 ENST00000489952
    ENST00000467689 ENST00000439069 ENST00000493428 ENST00000482314 ENST00000468062
    ENST00000444560
    miRNA
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    GenScript: all cDNA clones in your preferred vector: MAP4K2 (NM_004579)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP4K2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K2
    Sirion Biotech Customized lentivirus for stable overexpression of MAP4K2 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP4K2

    Additional mRNA sequence: 

    AF161342.1 AK298383.1 AK304495.1 BC039839.1 BC047865.1 U07349.1 

    12 DOTS entries:

    DT.443835  DT.100779893  DT.100779894  DT.120757178  DT.100703364  DT.95369999  DT.75116017  DT.86855533 
    DT.40131571  DT.91746850  DT.100801480  DT.120757187 

    24/136 AceView cDNA sequences (see all 136):

    BC047865 BQ024064 AW083515 BF941089 AW574847 CR619340 AI360253 BM919933 
    BM722816 BX108492 CF126017 BF438290 BX364218 CD366893 BE901934 BQ710831 
    CA306432 NM_004579 AW613323 BM727323 BX420108 BM458161 CR609548 BM720502 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                                    -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b
    SP1:                                                                  
    SP2:                                                                  
    SP3:                    -     -                                       
    SP4:                                                                  


    ECgene alternative splicing isoforms for MAP4K2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP4K2 expression in normal human tissues (normalized intensities)      MAP4K2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGCAAGG
    MAP4K2 Expression
    About this image


    MAP4K2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             bone marrow   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Lymph (Hematopoietic System)    fully expand to see all 3 entries
             lymph node ; non-germinal center cells   
             lymph node   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   

    See MAP4K2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP4K2

    SOURCE GeneReport for Unigene cluster: Hs.534341

    UniProtKB/Swiss-Prot: M4K2_HUMAN, Q12851
    Tissue specificity: Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain
    and placenta and at lower levels in other tissues examined

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAP4K2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map4k21 , 5 mitogen-activated protein kinase kinase kinase kinase more1, 5 87.6(n)1
    93.9(a)1
      19 (4.46 cM)5
    264121  NM_009006.21  NP_033032.11 
     63411355 
    zebrafish
    (Danio rerio)
    Actinopterygii map4k2l1 mitogen-activated protein kinase kinase kinase kinase more 61.48(n)
    60.57(a)
      678610  NM_001040358.1  NP_001035448.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70973 protein amino acid phosphorylation
    receptor signaling more
    57(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea gck-26
    Protein GCK-2
    38(a)
    1 → many
    V(6788454-6792665)


    ENSEMBL Gene Tree for MAP4K2 (if available)
    TreeFam Gene Tree for MAP4K2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP4K2 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K12  MAP4K32  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    18/28 SIMAP similar genes for MAP4K2 using alignment to 6 protein entries:     M4K2_HUMAN (see all proteins) (see all similar genes):
    MAP4K5    CDK2    MINK1    MAP4K3    MAP4K1    CDK12
    MAP4K4    STK3    TNIK    STK25    MST4    PAK1
    MYO3A    STK24    STK4    CDK10    PAK2    MYO3B

    MAP4K2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/462 SNPs in MAP4K2 are shown (see all 462)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048942611,2
    Cpathogenic164491655(-) CAGCCC/TGAGGC 2 -- us2k10--------
    rs1048942671,2
    Cpathogenic164491856(-) TGAGCC/TGAGAG 2 -- us2k10--------
    rs1048942591,2
    Cpathogenic164492145(-) TGGGCA/C/TGGGCC 2 -- us2k10--------
    rs1048942641,2
    Cpathogenic164492199(-) TCTACA/GACGGC 2 -- us2k10--------
    rs1179256261,2
    F--64475712(+) TCCCAT/CCCAAT 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1911129371,2
    --64475874(+) CAGGGC/GTCACC 1 -- ds50010--------
    rs1165646791,2
    F--64475893(+) TCCTAC/TGTGGG 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1137511761,2
    --64476133(+) ACAGAC/AACGTG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs22297211,2
    F--64476495(-) GCCCTG/TCTGGG 1 -- ut31 ese31Minor allele frequency- T:0.03MN 40
    rs1386702751,2
    C,F--64476646(+) TTGCTG/ATGCGC 2 /H syn11Minor allele frequency- A:0.00NA 4204

    HapMap Linkage Disequilibrium report for MAP4K2 (64556290 - 64570713 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MAP4K2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897702CNV Loss21882294
    dgv72n21CNV Loss19592680
    dgv1172n71CNV Loss21882294
    nsv528506CNV Loss19592680
    nsv897703CNV Loss21882294
    nsv469962CNV Loss18288195
    nsv897694CNV Loss21882294
    nsv832189CNV Loss17160897
    dgv153n27CNV Loss19166990
    dgv1171n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603166    OMIM disorders: --

    13 diseases for MAP4K2:    About MalaCards
    anoxia    gout    non-small cell lung carcinoma    multiple endocrine neoplasia
    pulmonary fibrosis    melanoma    diabetes mellitus    endotheliitis
    retinitis    anemia    hepatocellular carcinoma    prostatitis
    neuronitis


    MAP4K2 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for MAP4K2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal failure acute ischemic 59.1 1 16316999 (1)
    necrosis 13.1 6 12591926 (1), 11784851 (1), 11287630 (1), 10490605 (1)
    tumors 1.26 7 12591926 (1), 11784851 (1), 11287630 (1), 9024636 (1) (see all 5)
    melanoma 0 3 10702802 (2)
    cancer 0 2 17073713 (1), 17121938 (1)

    Genetic Association Database (GAD): MAP4K2
    Human Genome Epidemiology (HuGE) Navigator: MAP4K2 (3 documents)

    Export disorders for MAP4K2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP4K2 gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with MAP4K2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center. (PubMed id 7515885)1, 2, 3, 9 Katz P.... Kehrl J.H. (1994)
    2. Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. (PubMed id 11784851)1, 2, 9 Chadee D.N.... Kyriakis J.M. (2002)
    3. Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. (PubMed id 9712898)1, 2, 9 Yuasa T....Kyriakis J.M. (1998)
    4. Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. (PubMed id 17584736)1, 2, 9 Zhong J. and Kyriakis J.M. (2007)
    5. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. (PubMed id 7477268)1, 2, 9 Pombo C.M....Kyriakis J.M. (1995)
    6. Genome-wide association study for serum urate concent rations and gout among African Americans identifies genomic risk loci and a nov el URAT1 loss-of-function allele. (PubMed id 21768215)1, 4 Tin A....KAPttgen A. (2011)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Germinal center kinase is required for optimal Jun N-terminal kinase activation by Toll-like receptor agonists and is regulated by the ubiquitin proteasome system and agonist-induced, TRAF6-dependent stabilization. (PubMed id 15456887)2, 9 Zhong J. and Kyriakis J.M. (2004)
    9. In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. (PubMed id 8643544)1, 9 Ren M....Sabatini D.D. (1996)
    10. The Ste20 group kinases as regulators of MAP kinase cascades. (PubMed id 11316611)2, 9 Dan I....Kusumi A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5871 HGNC: 6864 AceView: MAP4K2 Ensembl:ENSG00000168067 euGenes: HUgn5871
    ECgene: MAP4K2 Kegg: 5871 H-InvDB: MAP4K2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP4K2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP4K2 gene:
    Search GeneIP for patents involving MAP4K2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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