Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MAP4K2 Gene

protein-coding   GIFtS: 68
GCID: GC11M064556

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2


(Previous symbol: RAB8IP)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 21 2     B Lymphocyte Serine/Threonine Protein Kinase2
RAB8IP1 2 3 5     Germinal Centre Kinase (GC Kinase)2
GCK2 3 5     Rab8 Interacting Protein2
MAPK/ERK Kinase Kinase Kinase 22 3     B Lymphocyte Serine/Threonine-Protein Kinase3
MEK Kinase Kinase 22 3     GC Kinase3
MEKKK 22 3     Germinal Center Kinase3
EC 2.7.11.13 8     Rab8-Interacting Protein3
BL442     EC 2.7.118

External Ids:    HGNC: 68641   Entrez Gene: 58712   Ensembl: ENSG000001680677   OMIM: 6031665   UniProtKB: Q128513   

Export aliases for MAP4K2 gene to outside databases

Previous GC identifers: GC11M067072 GC11M066238 GC11M064806 GC11M064331 GC11M064313 GC11M060883


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MAP4K2 Gene:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase
is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre,
where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown
to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2
(TRAF2), which is involved in the activation of MAP3K1/MEKK1. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP4K2 Gene:
MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and mitogen-activated protein kinase kinase kinase binding. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: M4K2_HUMAN, Q12851
Function: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal
transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the
stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the
p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including
pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides
(LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also
stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling,
and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization,
which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation.
Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks
MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of
vesicle targeting or fusion

Gene Wiki entry for MAP4K2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP4K2 gene promoter:
         COUP-TF1   COUP-TF   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP4K2 promoter sequence
   Search Chromatin IP Primers for MAP4K2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP4K2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

MAP4K2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4K2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M064556:  view genomic region     (about GC identifiers)

Start:
64,556,290 bp from pter      End:
64,570,713 bp from pter
Size:
14,424 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: M4K2_HUMAN, Q12851 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 2  
Size: 820 amino acids; 91556 Da
Cofactor: Magnesium
Subunit: Interacts with TRAF2, TRAF6, MAP3K1/MEKK1 and MAP3K11/MLK3. Interacts with RAB8A (By similarity)
Sequence caution: Sequence=AAA20968.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part;

Explore the universe of human proteins at neXtProt for MAP4K2: NX_Q12851

Explore proteomics data for MAP4K2 at MOPED

Post-translational modifications: 

  • Polyubiquitinated through 'Lys-48'-polyubiquitin chains, allowing proteasomal turnover. Ubiquitination requires
    the kinase activity of MAP4K2/GCK1
  • Autophosphorylated in response to tumor necrosis factor (TNF), endotoxins or proinflammatory stimuli.
    Autophosphorylation leads to activation1
  • Ubiquitination2 at Lys32
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP4K2 (Q12851) (see all 9)
     GITAIEL  VKLADFG  PKKRPTA  MEFCGGGS 


    See MAP4K2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004570.2  
    ENSEMBL proteins: 
     ENSP00000400594   ENSP00000403410   ENSP00000294066   ENSP00000366567   ENSP00000413167  
     ENSP00000403563   ENSP00000404534  

    MAP4K2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAP4K2 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAP4K2
    OriGene Protein Over-expression Lysate for MAP4K2
    OriGene MassSpec for MAP4K2
    OriGene Custom Protein Services for MAP4K2
    GenScript Custom Purified and Recombinant Proteins Services for MAP4K2
    Novus Biologicals MAP4K2 Protein
    Novus Biologicals MAP4K2 Lysates
    Sino Biological Recombinant Protein for MAP4K2
    Sino Biological Cell Lysate for MAP4K2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP4K2

     
    Search eBioscience for Proteins for MAP4K2 

    MAP4K2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MAP4K2  (GCK)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MAP4K2
    Novus Biologicals MAP4K2 Antibodies
    Abcam antibodies for MAP4K2
    Cloud-Clone Corp. Antibodies for MAP4K2
    ThermoFisher Antibodies for MAP4K2
    LSBio Antibodies in human, mouse, rat for MAP4K2

    MAP4K2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAP4K2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP4K2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP4K2
    Cloud-Clone Corp. CLIAs for MAP4K2
    Search eBioscience for ELISAs for MAP4K2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    MAP4K: Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase kinase 2
    KHS subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR001180 Citron

    Graphical View of Domain Structure for InterPro Entry Q12851

    ProtoNet protein and cluster: Q12851

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: M4K2_HUMAN, Q12851
    Domain: The PEST domains are Pro-, Glu-, Ser-, and Thr-rich domains. Proteins with PEST domains are frequently
    targets of degradation by the ubiquitin proteasome
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAP4K2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M4K2_HUMAN, Q12851
    Function: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal
    transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the
    stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the
    p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including
    pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides
    (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also
    stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling,
    and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization,
    which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation.
    Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks
    MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of
    vesicle targeting or fusion
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: The tumor necrosis factor (TNF), as well as endotoxins and proinflammatory stimuli such as
    polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), peptidoglycan (PGN), flagellin, or lipid A
    activate MAP4K2 by promoting its autophosphorylation

         Genatlas biochemistry entry for MAP4K2:
    mitogen-activated kinase kinase kinase kinase 2,located in the MEN1 critical region

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA11784851
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding IPI11784851
         
    Find genes that share ontologies with MAP4K2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAP4K2:
     Decreased substrate adherent c  Increased G2M DNA content, inc 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Map4k2):
     no phenotypic analysis 

    Find genes that share phenotypes with MAP4K2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Map4k2tm1Jmky for MAP4K2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP4K2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP4K2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP4K2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP4K2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP4K2:
    hsa-mir-1 (MIRT024097)

    Block miRNA regulation of human, mouse, rat MAP4K2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP4K2 (see all 18):
    hsa-miR-3678-3p hsa-miR-3673 hsa-miR-137 hsa-miR-25 hsa-miR-613 hsa-miR-3155b hsa-miR-92b hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidMAP4K2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP4K2
    Predesigned siRNA for gene silencing in human, mouse, rat MAP4K2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP4K2

    Clone
    Products:
         
    OriGene clones in human, mouse for MAP4K2 (see all 8)
    OriGene ORF clones in mouse, rat for MAP4K2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP4K2 (NM_004579)
    Sino Biological Human cDNA Clone for MAP4K2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP4K2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K2
    Addgene plasmids for MAP4K2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAP4K2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP4K2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    M4K2_HUMAN, Q12851: Cytoplasm (By similarity). Basolateral cell membrane; Peripheral membrane protein (By
    similarity). Golgi apparatus membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane5
    cytosol3
    cytoskeleton1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm IBA--
    GO:0016323basolateral plasma membrane IEA--

    Find genes that share ontologies with MAP4K2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MAP4K2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TNFR1 Pathway0.56
    Apoptosis and survival TNFR1 signaling pathway0.52
    2TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    4TRAF Pathway
    TRAF Pathway0.42
    5MAPK targets/ Nuclear events mediated by MAP kinases
    MAP Kinase Signaling0.31


    Find genes that share SuperPaths with MAP4K2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP4K2
        TRAF Pathway
    JNK Pathway
    MAPK Family Pathway
    TNFR1 Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP4K2
        MAP Kinase Signaling

    2 GeneGo (Thomson Reuters) Pathways for MAP4K2
        Signal transduction JNK pathway
    Apoptosis and survival TNFR1 signaling pathway

    2 BioSystems Pathways for MAP4K2
        Insulin Signaling
    TNF receptor signaling pathway



    1 Kegg Pathway  (Kegg details for MAP4K2):
        MAPK signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAP4K2
    Interactions:

        GeneGlobe Interaction Network for MAP4K2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for MAP4K2 (Q128511, 2, 3 ENSP000002940664) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K1Q132331, 3, ENSP000003824234EBI-49783,EBI-49776 I2D: score=4 STRING: ENSP00000382423
    HNRNPA2B1P226262, 3, ENSP000003466944MINT-8260427 I2D: score=2 STRING: ENSP00000346694
    NACADO150692, 3MINT-8260438 I2D: score=2 
    PRDX4Q131622, 3MINT-8260449 I2D: score=2 
    SERPINA4P296222, 3MINT-8260460 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000185activation of MAPKKK activity IBA--
    GO:0006468protein phosphorylation IDA11784851
    GO:0006903vesicle targeting IEA--
    GO:0006950response to stress ----
    GO:0006955immune response TAS7515885

    Find genes that share ontologies with MAP4K2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP4K2 (M4K2)

    3 HMDB Compounds for MAP4K2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    10 Novoseek inferred chemical compound relationships for MAP4K2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 78.1 36 18691424 (2), 8643544 (2), 9341881 (1), 12358757 (1) (see all 30)
    serine 68.8 32 18691424 (2), 8643544 (2), 12358757 (1), 16957890 (1) (see all 27)
    phosphatidylinositol 58 5 17073713 (1), 18187933 (1), 11287630 (1), 15138635 (1) (see all 5)
    rapamycin 24.8 1 16195541 (1)
    glycogen 24.5 3 9582355 (1), 10637513 (1), 11257494 (1)
    phosphoinositide 15.4 2 12358757 (1), 12244133 (1)
    lipid 0 1 12244133 (1)
    glucose 0 1 14749367 (1)
    calcium 0 4 19188511 (1)
    tyrosine 0 3 20182580 (1), 11287630 (1), 11782427 (1)



    Find genes that share compounds with MAP4K2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MAP4K2 gene: 
    NM_004579.3  

    Unigene Cluster for MAP4K2:

    Mitogen-activated protein kinase kinase kinase kinase 2
    Hs.534341  [show with all ESTs]
    Unigene Representative Sequence: NM_004579
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435926 ENST00000424945 ENST00000470088 ENST00000294066(uc001obh.3)
    ENST00000377350(uc001obi.3 uc010rnp.1) ENST00000433890 ENST00000489952
    ENST00000467689 ENST00000439069 ENST00000493428 ENST00000482314 ENST00000468062
    ENST00000444560
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAP4K2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP4K2 (see all 18):
    hsa-miR-3678-3p hsa-miR-3673 hsa-miR-137 hsa-miR-25 hsa-miR-613 hsa-miR-3155b hsa-miR-92b hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidMAP4K2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAP4K2
    Predesigned siRNA for gene silencing in human, mouse, rat MAP4K2
    Clone
    Products:
         
    OriGene clones in human, mouse for MAP4K2 (see all 8)
    OriGene ORF clones in mouse, rat for MAP4K2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP4K2 (NM_004579)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP4K2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K2
    Addgene plasmids for MAP4K2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP4K2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP4K2
      QuantiTect SYBR Green Assays in human, mouse, rat MAP4K2
      QuantiFast Probe-based Assays in human, mouse, rat MAP4K2

    Additional mRNA sequence: 

    AF161342.1 AK298383.1 AK304495.1 BC039839.1 BC047865.1 U07349.1 

    12 DOTS entries:

    DT.443835  DT.100779893  DT.100779894  DT.120757178  DT.100703364  DT.95369999  DT.75116017  DT.86855533 
    DT.40131571  DT.91746850  DT.100801480  DT.120757187 

    Selected AceView cDNA sequences (see all 136):

    BX378991 BQ686424 BX642059 AW083515 BM919933 AI360253 BX364218 BQ710831 
    AW299663 BM458161 CA306432 AI018229 CR619340 CF126017 BX108492 CF887586 
    AW613323 BF438290 BM727323 BM681702 CR593128 BE902154 AW025111 BF941089 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                                    -                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b
    SP1:                                                                  
    SP2:                                                                  
    SP3:                    -     -                                       
    SP4:                                                                  


    ECgene alternative splicing isoforms for MAP4K2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MAP4K2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGCAAGG
    MAP4K2 Expression
    About this image


    MAP4K2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
    MAP4K2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP4K2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534341

    UniProtKB/Swiss-Prot: M4K2_HUMAN, Q12851
    Tissue specificity: Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain
    and placenta and at lower levels in other tissues examined

        Custom PCR Arrays for MAP4K2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP4K2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP4K2
    QuantiTect SYBR Green Assays in human, mouse, rat MAP4K2
    QuantiFast Probe-based Assays in human, mouse, rat MAP4K2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP4K2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map4k21 , 5 mitogen-activated protein kinase kinase kinase kinase more1, 5 87.6(n)1
    93.9(a)1
      19 (4.46 cM)5
    264121  NM_009006.21  NP_033032.11 
     63411355 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1363541 zgc:136354 62.6(n)
    61.69(a)
      692287  NM_001045260.2  NP_001038725.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70973 protein amino acid phosphorylation
    receptor signaling more
    57(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea gck-26
    Protein GCK-2 (gck-2) mRNA, complete cds
    39(a)
    1 → many
    V(6788454-6792665) WBGene00022603
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIC16
    Protein kinase of the PAK/Ste20 family, required f...
    18(a)
    1 → many
    VIII(316572-319814) YHR102W


    ENSEMBL Gene Tree for MAP4K2 (if available)
    TreeFam Gene Tree for MAP4K2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MAP4K2 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K12  MAP4K32  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    Selected SIMAP similar genes for MAP4K2 using alignment to 6 protein entries:     M4K2_HUMAN (see all proteins) (see all similar genes):
    MAP4K5    CDK2    MINK1    MAP4K3    MAP4K1    CDK12
    MAP4K4    STK3    TNIK    STK25    MST4    PAK1
    MYO3A    STK24    STK4    CDK10    PAK2    MYO3B

    Find genes that share paralogs with MAP4K2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MAP4K2 (see all 462)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048942611,2
    Cpathogenic164491655(-) CAGCCC/TGAGGC 2 -- us2k10--------
    rs1048942671,2
    Cpathogenic164491856(-) TGAGCC/TGAGAG 2 -- us2k10--------
    rs1048942591,2
    Cpathogenic164492145(-) TGGGCA/C/TGGGCC 2 -- us2k10--------
    rs1048942641,2
    Cpathogenic164492199(-) TCTACA/GACGGC 2 -- us2k10--------
    rs1179256261,2
    F--64475712(+) TCCCAT/CCCAAT 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1911129371,2
    --64475874(+) CAGGGC/GTCACC 1 -- ds50010--------
    rs1165646791,2
    F--64475893(+) TCCTAC/TGTGGG 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1137511761,2
    --64476133(+) ACAGAC/AACGTG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs22297211,2
    F--64476495(-) GCCCTG/TCTGGG 1 -- ut31 ese31Minor allele frequency- T:0.03MN 40
    rs1386702751,2
    C,F--64476646(+) TTGCTG/ATGCGC 2 /H syn11Minor allele frequency- A:0.00NA 4204

    HapMap Linkage Disequilibrium report for MAP4K2 (64556290 - 64570713 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MAP4K2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897702CNV Loss21882294
    dgv72n21CNV Loss19592680
    dgv1172n71CNV Loss21882294
    nsv528506CNV Loss19592680
    nsv897703CNV Loss21882294
    nsv469962CNV Loss18288195
    nsv897694CNV Loss21882294
    nsv832189CNV Loss17160897
    dgv153n27CNV Loss19166990
    dgv1171n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP4K2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP4K2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603166    OMIM disorders: --


    Find genes that share disorders with MAP4K2           About GenesLikeMe

    5 Novoseek inferred disease relationships for MAP4K2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal failure acute ischemic 59.1 1 16316999 (1)
    necrosis 13.1 6 12591926 (1), 11784851 (1), 11287630 (1), 10490605 (1)
    tumors 1.26 7 12591926 (1), 11784851 (1), 11287630 (1), 9024636 (1) (see all 5)
    melanoma 0 3 10702802 (2)
    cancer 0 2 17073713 (1), 17121938 (1)

    Genetic Association Database (GAD): MAP4K2
    Human Genome Epidemiology (HuGE) Navigator: MAP4K2 (3 documents)

    Export disorders for MAP4K2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MAP4K2 gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with MAP4K2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center. (PubMed id 7515885)1, 2, 3, 9 Katz P.... Kehrl J.H. (J. Biol. Chem. 1994)
    2. Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. (PubMed id 11784851)1, 2, 9 Chadee D.N.... Kyriakis J.M. (Mol. Cell. Biol. 2002)
    3. Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen- activated protein kinase kinase kinase upstream of MKK6 and p38. (PubMed id 9712898)1, 2, 9 Yuasa T.... Kyriakis J.M. (J. Biol. Chem. 1998)
    4. Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. (PubMed id 17584736)1, 2, 9 Zhong J. and Kyriakis J.M. (J. Biol. Chem. 2007)
    5. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. (PubMed id 7477268)1, 2, 9 Pombo C.M.... Kyriakis J.M. (Nature 1995)
    6. Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele. (PubMed id 21768215)1, 4 Tin A....KAPttgen A. (Hum. Mol. Genet. 2011)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Germinal center kinase is required for optimal Jun N-terminal kinase activation by Toll-like receptor agonists and is regulated by the ubiquitin proteasome system and agonist-induced, TRAF6-dependent stabilization. (PubMed id 15456887)2, 9 Zhong J. and Kyriakis J.M. (Mol. Cell. Biol. 2004)
    9. In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. (PubMed id 8643544)1, 9 Ren M....Sabatini D.D. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    10. The Ste20 group kinases as regulators of MAP kinase cascades. (PubMed id 11316611)2, 9 Dan I.... Kusumi A. (Trends Cell Biol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5871 HGNC: 6864 AceView: MAP4K2 Ensembl:ENSG00000168067 euGenes: HUgn5871
    ECgene: MAP4K2 Kegg: 5871 H-InvDB: MAP4K2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MAP4K2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MAP4K2 gene:
    Search GeneIP for patents involving MAP4K2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant MAP4K2 Protein
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MAP4K2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MAP4K2  
     OriGene MassSpec something-or-other for MAP4K2   OriGene clones in human, mouse for MAP4K2  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAP4K2   OriGene Purified Protein for MAP4K2  
     OriGene ORF clones in mouse, rat for MAP4K2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAP4K2   OriGene Custom Protein Services for MAP4K2  

     
     
     Block miRNA regulation of human, mouse, rat MAP4K2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MAP4K2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP4K2 Predesigned siRNA for gene silencing in human, mouse, rat MAP4K2
     QuantiFast Probe-based Assays in human, mouse, rat MAP4K2 QuantiTect SYBR Green Assays in human, mouse, rat MAP4K2
     Custom PCR Arrays for MAP4K2 Search Chromatin IP Primers for MAP4K2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP4K2  GeneGlobe Interaction Network for MAP4K2
     Regulatory tfbs in MAP4K2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MAP4K2 GenScript cDNA clones with any tag delivered in your preferred vector for MAP4K2
     GenScript Custom Assay Services for MAP4K2 GenScript Custom overexpressing Cell Line Services for MAP4K2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for MAP4K2  (GCK)

     Search Tocris compounds for MAP4K2 (M4K2)
     Proteins for MAP4K2
     Cell Lysates for MAP4K2
     cDNA Clones for MAP4K2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MAP4K2 antibodies
     MAP4K2 proteins
     MAP4K2 lysates
     Antibodies for MAP4K2
     See all of Abcam's Antibodies, Kits and Proteins for MAP4K2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MAP4K2
     Antibodies for MAP4K2
     ELISAs for MAP4K2
     CLIAs for MAP4K2



     Browse ESI BIO Cell Lines and PureStem Progenitors for MAP4K2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K2
     SwitchGear 3'UTR luciferase reporter plasmids for MAP4K2
     SwitchGear Promoter luciferase reporter plasmids for MAP4K2
     ThermoFisher Antibodies for MAP4K2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP4K2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP4K2
     LSBio Antibodies in human, mouse, rat for MAP4K2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for MAP4K2
      Search eBioscience for proteins for MAP4K2
      Search eBioscience for elisas for MAP4K2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAP4K2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4