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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP4K1 Gene

protein-coding   GIFtS: 64
GCID: GC19M039078

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 11 2     MEKKK 12 3
HPK12 3 5     EC 2.7.11.13 8
Hematopoietic Progenitor Kinase 11 2     Hematopoietic Progenitor Kinase3
MAPK/ERK Kinase Kinase Kinase 12 3     EC 2.7.118
MEK Kinase Kinase 12 3     

External Ids:    HGNC: 68631   Entrez Gene: 111842   Ensembl: ENSG000001048147   OMIM: 6019835   UniProtKB: Q929183   

Export aliases for MAP4K1 gene to outside databases

Previous GC identifers: GC19M039692 GC19M039469 GC19M043754 GC19M043770 GC19M035526


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MAP4K1 Gene: 
MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1) is a protein-coding gene. Diseases associated with MAP4K1 include pancreatic cancer, and pancreatitis, and among its related super-pathways are MAPK signaling pathway and B cell receptor signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and small GTPase regulator activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918
Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal
pathway. May play a role in hematopoietic lineage decisions and growth regulation

Gene Wiki entry for MAP4K1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP4K1 gene promoter:
         SRF   SRF (504 AA)   ATF-2   CUTL1   E47   c-Ets-1   YY1   Hand1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP4K1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP4K1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP4K1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1-q13.4   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1-q13.4

MAP4K1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4K1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039078:  view genomic region     (about GC identifiers)

Start:
39,078,281 bp from pter      End:
39,109,522 bp from pter
Size:
31,242 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 1  
Size: 833 amino acids; 91296 Da
Cofactor: Magnesium
Subunit: Interacts with MAP3K1
Alternative splicing: 2 isoforms:  Q92918-1   Q92918-2   

Explore the universe of human proteins at neXtProt for MAP4K1: NX_Q92918

Explore proteomics data for MAP4K1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92918

  • 4/8 DME Specific Peptides for MAP4K1 (Q92918) (see all 8)
     CDIWSLG  GITAIEL  LFLMTKS  MDGSVKL 

    MAP4K1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP4K1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001036065.1  NP_009112.1  

    ENSEMBL proteins: 
     ENSP00000465039   ENSP00000465774   ENSP00000468164   ENSP00000380066   ENSP00000465303  
     ENSP00000468396   ENSP00000396383  

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    OriGene Protein Over-expression Lysate for MAP4K1
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    Novus Biologicals MAP4K1 Proteins
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    Cloud-Clone Corp. Proteins for MAP4K1 


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    Cloud-Clone Corp. ELISAs for MAP4K1 
    Cloud-Clone Corp. CLIAs for MAP4K1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAP4K: Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase kinase 1 
    KHS subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR001180 Citron

    Graphical View of Domain Structure for InterPro Entry Q92918

    ProtoNet protein and cluster: Q92918

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    MAP4K1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M4K1_HUMAN, Q92918
    Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal
    pathway. May play a role in hematopoietic lineage decisions and growth regulation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for MAP4K1:
    mitogen-activated kinase kinase kinase kinase 1,nuclear,predominantly expressed in hematopoietic cells,binding
    MAP3K1 (MEKK1) activating the JNK/SAPK kinase pathway

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS8824585
    GO:0004674protein serine/threonine kinase activity IDA8824585
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding IPI17474147
         
    MAP4K1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MAP4K1:
     Increased viability with 4OH t 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Map4k1):
     cellular  hematopoietic system  immune system 

    MAP4K1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAP4K1: Map4k1tm1Ssaw Map4k1tm1Tht

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP4K1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP4K1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP4K1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP4K1 

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAP4K1 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2B cell receptor signaling pathway
    BCR signaling pathway0.42
    TCR Signaling Pathway0.35
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    4Signal transduction JNK pathway
    Signal transduction JNK pathway0.98
    5TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD4+ T cells0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MAP4K1
        Signal transduction JNK pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP4K1
        TGF-Beta Pathway
    JNK Pathway
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP4K1
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for MAP4K1
        Signal transduction JNK pathway

    5/10 BioSystems Pathways for MAP4K1 (see all 10)
        MAPK signaling pathway
    Insulin Signaling
    TCR Signaling Pathway
    B Cell Receptor Signaling Pathway
    Prostate Cancer


    1         Kegg Pathway  (Kegg details for MAP4K1):
        MAPK signaling pathway


    MAP4K1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP4K1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for MAP4K1 (Q929181, 2, 3 ENSP000003800664) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-881,EBI-375543 MINT-8110527 MINT-7213035 I2D: score=5 STRING: ENSP00000361423
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-881,EBI-79464 MINT-8112075 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191741, 2, 3, ENSP000002440074EBI-881,EBI-79387 MINT-8112639 I2D: score=3 STRING: ENSP00000244007
    CRKP461081, 3, ENSP000003005744EBI-881,EBI-886 I2D: score=5 STRING: ENSP00000300574
    CRKLP461091, 3, ENSP000003463004EBI-881,EBI-910 I2D: score=5 STRING: ENSP00000346300
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000185activation of MAPKKK activity IC11053428
    GO:0006468protein phosphorylation IDA8824585
    GO:0006950response to stress IDA8824585
    GO:0007243intracellular protein kinase cascade IDA8824585
    GO:0007257activation of JUN kinase activity TAS8824585

    MAP4K1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP4K1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP4K1 (M4K1)

    3 HMDB Compounds for MAP4K1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    3 Novoseek inferred chemical compound relationships for MAP4K1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 64.9 15 9346925 (3), 9891069 (1), 9820741 (1), 15364934 (1) (see all 8)
    serine 51.8 10 9346925 (1), 9891069 (1), 9820741 (1), 15364934 (1) (see all 7)
    tyrosine 22.9 11 9346925 (3), 11279207 (2), 15743830 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP4K1 / M4K1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP4K1 gene (2 alternative transcripts): 
    NM_001042600.1  NM_007181.4  

    Unigene Cluster for MAP4K1:

    Mitogen-activated protein kinase kinase kinase kinase 1
    Hs.95424  [show with all ESTs]
    Unigene Representative Sequence: NM_007181
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593196 ENST00000591517 ENST00000586296 ENST00000589130 ENST00000396857(uc002oix.1 uc002oiy.1)
    ENST00000591210 ENST00000591921 ENST00000588938 ENST00000585583 ENST00000589002
    ENST00000592888 ENST00000591707 ENST00000592225 ENST00000588083 ENST00000587300
    ENST00000423454(uc010xug.2)
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    Additional mRNA sequence: 

    AK303267.1 U66464.1 

    10 DOTS entries:

    DT.100748776  DT.99993411  DT.97785383  DT.100720540  DT.97843110  DT.100748775  DT.40117714  DT.97825790 
    DT.121471144  DT.97792486 

    24/115 AceView cDNA sequences (see all 115):

    BG397271 BM693263 BQ430312 BQ441919 BQ073002 CR590852 BQ639344 AA749288 
    BX345201 CR599547 BM479454 AW408358 BG397984 AL561215 BQ437081 T50313 
    AW575048 BM665397 BG389576 CD623848 CR597185 AL560823 BQ064376 BF345585 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                          -     -                 -                                                                           
    SP2:                                                  -                                                                           
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for MAP4K1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP4K1 expression in normal human tissues (normalized intensities)      MAP4K1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAP4K1 Expression
    About this image


    MAP4K1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Peripheral blood Pan-T Cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Lymph (Hematopoietic System)
             LYMPH NODE   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)

    See MAP4K1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP4K1

    SOURCE GeneReport for Unigene cluster: Hs.95424

    UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918
    Tissue specificity: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also
    expressed at very low levels in lung, kidney, mammary glands and small intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP4K1: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Hematopoiesis in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAP4K1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map4k11 , 5 mitogen-activated protein kinase kinase kinase kinase more1, 5 84.7(n)1
    86.45(a)1
      7 (16.94 cM)5
    264111  NM_008279.21  NP_032305.21 
     289828545 
    lizard
    (Anolis carolinensis)
    Reptilia MAP4K16
    mitogen-activated protein kinase kinase kinase kin...
    55(a)
    1 ↔ 1
    GL343427.1(738666-785974)
    zebrafish
    (Danio rerio)
    Actinopterygii MAP4K16
    mitogen-activated protein kinase kinase kinase kin...
    64(a)
    1 ↔ 1
    15(46872584-46894317)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70973 protein amino acid phosphorylation
    receptor signaling more
    52(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea gck-26
    Protein GCK-2
    34(a)
    1 → many
    V(6788454-6792665)


    ENSEMBL Gene Tree for MAP4K1 (if available)
    TreeFam Gene Tree for MAP4K1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP4K1 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K32  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    18/61 SIMAP similar genes for MAP4K1 using alignment to 6 protein entries:     M4K1_HUMAN (see all proteins) (see all similar genes):
    COQ5    MAP4K5    MAP4K2    MAP4K3    CDKL4    MAPK3
    MST4    STK25    MAP4K4    STK3    ATF1    STK4
    STK24    PAK1    PAK2    MYO3A    PAK4    PHKG2

    MAP4K1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/733 SNPs in MAP4K1 are shown (see all 733)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407424
    A metastatic melanoma sample4--see VAR_0407422 S F mis40--------
    rs1399628281,2
    --39078737(+) CCTGAA/TGGGGG 2 -- int10--------
    rs1888248371,2
    --39078767(+) AAAGGA/GCAAGG 2 -- int10--------
    rs38486211,2
    F,H--39078851(+) GATGTC/TATGGC 2 -- int15Minor allele frequency- T:0.00MN NS EA 602
    rs1869156781,2
    --39078862(+) CTTGTA/GGGCTG 2 -- int10--------
    rs1897567781,2
    --39078915(+) TAAGCA/GGGGAG 2 -- int10--------
    rs1454143731,2
    --39079068(+) GCTCAC/TGCTTG 2 -- int10--------
    rs1471986911,2
    --39079071(+) CATGCC/TTGTAA 2 -- int10--------
    rs1995464311,2
    C--39079098(+) GCCAA-/GGGGGG 2 -- int10--------
    rs1814438471,2
    C--39079122(+) GGTCAC/GGAGTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for MAP4K1 (39078281 - 39109522 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MAP4K1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833828CNV Loss17160897
    dgv3858n71CNV Loss21882294
    nsv833824CNV Loss17160897
    nsv833826CNV Loss17160897
    nsv833827CNV Gain17160897
    nsv470140CNV Gain18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601983    OMIM disorders: --

    3 diseases for MAP4K1:    About MalaCards
    pancreatic cancer    pancreatitis    leukemia


    MAP4K1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MAP4K1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 19141650 (2)


    Export disorders for MAP4K1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP4K1 gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with MAP4K1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. (PubMed id 8824585)1, 2, 3, 9 Hu M.C.-T.... Tan T.-H. (1996)
    2. Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase. (PubMed id 9891069)1, 9 Ling P....Tan T.H. (1999)
    3. Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. (PubMed id 15364934)1, 9 Zhou G....Tan T.H. (2004)
    4. Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling. (PubMed id 11279207)1, 9 Ling P....Tan T.H. (2001)
    5. Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. (PubMed id 19141650)1, 9 Wang H....Wang H. (2009)
    6. Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1). (PubMed id 10602493)1, 9 Chen Y.R....Tan T.H. (1999)
    7. Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1. (PubMed id 15743830)1, 9 Arnold R....Kiefer F. (2005)
    8. Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes. (PubMed id 11313918)1, 9 Ma W....Liu M. (2001)
    9. Activation of hematopoietic progenitor kinase-1 by erythropoietin. (PubMed id 10233887)1, 9 Nagata Y....Todokoro K. (1999)
    10. Phosphorylation of CARMA1 by HPK1 is critical for NF- kappaB activation in T cells. (PubMed id 19706536)1, 9 Brenner D....Arnold R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11184 HGNC: 6863 AceView: MAP4K1 Ensembl:ENSG00000104814 euGenes: HUgn11184
    ECgene: MAP4K1 Kegg: 11184 H-InvDB: MAP4K1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP4K1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP4K1 gene:
    Search GeneIP for patents involving MAP4K1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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