MAP4K1 Gene
protein-coding GIFtS: 61
GCID: GC19M039078
|
|
mitogen-activated protein kinase kinase kinase kinase 1
| |
Aliases
for MAP4K1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitogen-Activated Protein Kinase Kinase Kinase Kinase 11 2 | | EC 2.7.11.13 8 | | HPK11 2 3 5 | | Hematopoietic Progenitor Kinase 12 | | MAPK/ERK Kinase Kinase Kinase 12 3 | | Hematopoietic Progenitor Kinase3 | | MEK Kinase Kinase 12 3 | | EC 2.7.118 | | MEKKK 12 3 | | |
Export aliases for MAP4K1 gene to outside databasesPrevious GC identifers: GC19M039692 GC19M039469 GC19M043754 GC19M043770 GC19M035526 |
Summaries
for MAP4K1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminalpathway. May play a role in hematopoietic lineage decisions and growth regulation
Gene Wiki entry for MAP4K1
|
Genomic Views
for MAP4K1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP4K1 gene promoter:
SRF SRF (504 AA) ATF-2 CUTL1 E47 c-Ets-1 YY1 Hand1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP4K1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP4K1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1-q13.4 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1-q13.4MAP4K1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M039078: view genomic region
(about GC identifiers)
Start:
|
39,078,281 bp from pter |
End:
|
39,109,522 bp from pter |
Size:
|
31,242 bases |
Orientation:
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minus strand |
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Proteins
for MAP4K1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918 (See
protein sequence)Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 1 Size: 833 amino acids; 91296 Da
Cofactor: Magnesium
Subunit: Interacts with MAP3K1Alternative splicing: 2 isoforms: Q92918-1 Q92918-2 Explore the universe of human proteins at neXtProt for MAP4K1: NX_Q92918
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92918
4/8 DME Specific Peptides for MAP4K1 (Q92918) (see all 8)
MAP4K1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001036065.1 NP_009112.1
ENSEMBL proteins: ENSP00000465039 ENSP00000465774 ENSP00000468164 ENSP00000380066 ENSP00000465303 ENSP00000468396 ENSP00000396383
Human Recombinant Protein Products for MAP4K1:
MAP4K1 Antibody Products:
Assay Products for MAP4K1: |
Protein
Domains /
Families
for MAP4K1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP4K1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q92918ProtoNet protein and cluster: Q92918 1 Blocks protein family: IPB001180 Citron-like
UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamilySimilarity: Contains 1 CNH domainSimilarity: Contains 1 protein kinase domain |
Function
for MAP4K1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: M4K1_HUMAN, Q92918Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminalpathway. May play a role in hematopoietic lineage decisions and growth regulationCatalytic activity: ATP + a protein = ADP + a phosphoprotein Genatlas biochemistry entry for MAP4K1:mitogen-activated kinase kinase kinase kinase 1,nuclear,predominantly expressed in hematopoietic cells,binding MAP3K1(MEKK1) activating the JNK/SAPK kinase pathway
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
MAP4K1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MAP4K1:
3 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Map4k1):
MAP4K1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for MAP4K1: Map4k1tm1Ssaw Map4k1tm1Tht
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP4K1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP4K1 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MAP4K1 (NM_001042600) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP4K1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K1 |
|
Pathways & Interactions
for MAP4K1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TGF-Beta Pathway | | | 2 | Signal transduction_JNK pathway | | | 3 | MAPK signaling pathway | | | 4 | B cell receptor signaling pathway | | | 5 | Lymphocyte Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for MAP4K1
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP4K1
1 
Cell Signaling Technology (CST) Pathway for MAP4K1
1  GeneGo (Thomson Reuters) Pathway for MAP4K1
5/9  BioSystems Pathways for MAP4K1 (see all 9)
1 
Kegg Pathway (Kegg details for MAP4K1):
MAP4K1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP4K1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/43 Interacting proteins for MAP4K1 (Q929181, 2, 3 ENSP000003800664) via UniProtKB, MINT, STRING, and/or I2D (see all 43)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ABL1 | P005191, 2, 3, ENSP000003614234 | EBI-881,EBI-1550796 MINT-8110527 MINT-7213035 I2D:
score=5 STRING: ENSP00000361423 | | PIK3R1 | P279861, 2, 3, ENSP000002743354 | EBI-881,EBI-79464 MINT-8112075 I2D:
score=3 STRING: ENSP00000274335 | | PLCG1 | P191741, 2, 3, ENSP000002440074 | EBI-881,EBI-79387 MINT-8112639 I2D:
score=3 STRING: ENSP00000244007 | | CRK | P461081, 3, ENSP000003005744 | EBI-881,EBI-886 I2D:
score=5 STRING: ENSP00000300574 | | CRKL | P461091, 3, ENSP000003463004 | EBI-881,EBI-3451075 I2D:
score=5 STRING: ENSP00000346300 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
MAP4K1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAP4K1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MAP4K1 for compounds About GeneDecksing
 Browse Tocris compounds for MAP4K1
3 HMDB Compounds for MAP4K1 About this table
3 Novoseek chemical compound relationships for MAP4K1 gene About this table
Search CenterWatch for drugs/clinical trials and news about MAP4K1 / M4K1
|
Transcripts
for MAP4K1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAP4K1 gene (2 alternative transcripts): NM_001042600.1 NM_007181.4 Unigene Cluster for MAP4K1: Mitogen-activated protein kinase kinase kinase kinase 1 Hs.95424 [show with all ESTs]Unigene Representative Sequence: NM_00718116 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000593196 ENST00000591517 ENST00000586296 ENST00000589130 ENST00000396857(uc002oix.1 uc002oiy.1)
ENST00000591210 ENST00000591921 ENST00000588938 ENST00000585583 ENST00000589002
ENST00000592888 ENST00000591707 ENST00000592225 ENST00000588083 ENST00000587300
ENST00000423454(uc010xug.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP4K1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP4K1 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MAP4K1 (NM_001042600) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP4K1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K1 |
Additional cDNA sequence: AK303267.1 U66464.1 10 DOTS entries: DT.100748776 DT.99993411 DT.97785383 DT.100720540 DT.97843110 DT.100748775 DT.40117714 DT.97825790 DT.121471144 DT.97792486 24/115 AceView cDNA sequences (see all 115): BG397271 BG397984 BM693263 CR590852 BQ430312 CD623848 BQ064376 BQ073002 AL561215 BX345201 BQ441919 AW408358 BQ639344 BQ437081 CR597185 AW575048 AA749288 BM479454 T50313 CR599547 BG389576 AL560823 BM665397 AL582779
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAP4K1
|
Expression
for MAP4K1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAP4K1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MAP4K1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP4K1
SOURCE GeneReport for Unigene cluster: Hs.95424
UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918Tissue specificity: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Alsoexpressed at very low levels in lung, kidney, mammary glands and small intestine
SABiosciences Expression via Pathway-Focused PCR Arrays including MAP4K1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP4K1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP4K1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP4K1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP4K1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K1 |
Orthologs
for MAP4K1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAP4K1 gene from 3/17 species (see all 17) About this table
ENSEMBL Gene Tree for MAP4K1 (if available)
TreeFam Gene Tree for MAP4K1 (if available) |
Paralogs
for MAP4K1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAP4K1 gene
- TAOK22 MAP4K52 TAOK32 NRK2 TNIK2 MAP4K22 MAP4K32 MAP4K42
- TAOK12 STK102 MINK12 SLK2
18/65 SIMAP similar genes for MAP4K1 using alignment to 6 protein entries: M4K1_HUMAN (see all proteins)
(see all similar genes):COQ5 MAP4K5 MAP4K2 MAP4K3 CDKL4 MAPK3
MST4 STK25 MAP4K4 STK3 ATF1 STK4
STK24 PAK4 PAK1 PAK2 MYO3A PHKG2
MAP4K1 for paralogs About GeneDecksing
|
Genomic Variants
for MAP4K1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAP4K1 (39078281 - 39109522 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAP4K1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP4K1 |
|
Disorders
/ Diseases
for MAP4K1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAP4K1 for disorders About GeneDecksing
OMIM gene information: 601983
OMIM disorders: --
4  diseases for MAP4K1: About MalaCardscolon carcinoma pancreatic cancer pancreatitis carcinoma
1 Novoseek disease relationship for MAP4K1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
2 |
19141650 (2) |
Export disorders for MAP4K1 gene to outside databases
|
Publications
for MAP4K1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAP4K1 gene, integrated from 9 sources (see all 64):
(articles sorted by number of sources associating them with MAP4K1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. (PubMed id 8824585)1, 2, 3, 9 Hu M.C.-T.... Tan T.-H. (1996)
- Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase. (PubMed id 9891069)1, 9 Ling P....Tan T.H. (1999)
- Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. (PubMed id 15364934)1, 9 Zhou G....Tan T.H. (2004)
- Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling. (PubMed id 11279207)1, 9 Ling P....Tan T.H. (2001)
- Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. (PubMed id 19141650)1, 9 Wang H....Wang H. (2009)
- Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1). (PubMed id 10602493)1, 9 Chen Y.R....Tan T.H. (1999)
- Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1. (PubMed id 15743830)1, 9 Arnold R....Kiefer F. (2005)
- Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes. (PubMed id 11313918)1, 9 Ma W....Liu M. (2001)
- Activation of hematopoietic progenitor kinase-1 by erythropoietin. (PubMed id 10233887)1, 9 Nagata Y....Todokoro K. (1999)
- Phosphorylation of CARMA1 by HPK1 is critical for NF- kappaB activation in T cells. (PubMed id 19706536)1, 9 Brenner D....Arnold R. (2009)
|
External Searches for MAP4K1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAP4K1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAP4K1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAP4K1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAP4K1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MAP4K1 gene:
Search GeneIP for patents involving MAP4K1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAP4K1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MAP4K1 | | OriGene shRNA RFP for MAP4K1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP4K1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP4K1 | | | OriGene Protein Over-expression Lysate for MAP4K1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAP4K1 | | OriGene 3'-UTR Clone for MAP4K1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP4K1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP4K1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAP4K1 | | OriGene Custom Protein Services for MAP4K1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP4K1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP4K1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP4K1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP4K1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP4K1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP4K1 |
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| | Antibodies & Assays for MAP4K1 (HPK1) |
| | | | Search Tocris compounds for MAP4K1 |
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 | | | MAP4K1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K1 |
|  |  |  |  | | | | ThermoFisher Antibodies for MAP4K1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4K1 |
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