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MAP4K1 Gene

protein-coding   GIFtS: 64
GCID: GC19M039078

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 11 2     MEKKK 12 3
HPK12 3 5     EC 2.7.11.13 8
Hematopoietic Progenitor Kinase 11 2     Hematopoietic Progenitor Kinase3
MAPK/ERK Kinase Kinase Kinase 12 3     EC 2.7.118
MEK Kinase Kinase 12 3     

External Ids:    HGNC: 68631   Entrez Gene: 111842   Ensembl: ENSG000001048147   OMIM: 6019835   UniProtKB: Q929183   

Export aliases for MAP4K1 gene to outside databases

Previous GC identifers: GC19M039692 GC19M039469 GC19M043754 GC19M043770 GC19M035526


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAP4K1 Gene:
MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and small GTPase regulator activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918
Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal
pathway. May play a role in hematopoietic lineage decisions and growth regulation

Gene Wiki entry for MAP4K1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP4K1 gene promoter:
         SRF   SRF (504 AA)   ATF-2   CUTL1   E47   c-Ets-1   YY1   Hand1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP4K1 promoter sequence
   Search Chromatin IP Primers for MAP4K1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP4K1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1-q13.4   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1-q13.4

MAP4K1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4K1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039078:  view genomic region     (about GC identifiers)

Start:
39,078,281 bp from pter      End:
39,109,522 bp from pter
Size:
31,242 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 1  
Size: 833 amino acids; 91296 Da
Cofactor: Magnesium
Subunit: Interacts with MAP3K1
Alternative splicing: 2 isoforms:  Q92918-1   Q92918-2   

Explore the universe of human proteins at neXtProt for MAP4K1: NX_Q92918

Explore proteomics data for MAP4K1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys139
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP4K1 (Q92918) (see all 8)
     CDIWSLG  GITAIEL  LFLMTKS  MDGSVKL 


    See MAP4K1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001036065.1  NP_009112.1  

    ENSEMBL proteins: 
     ENSP00000465039   ENSP00000465774   ENSP00000468164   ENSP00000380066   ENSP00000465303  
     ENSP00000468396   ENSP00000396383  

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    Cloud-Clone Corp. Proteins for MAP4K1

     
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    antibodies-online proteins for MAP4K1 (3 products) 

     
    antibodies-online peptides for MAP4K1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP4K: Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase kinase 1
    KHS subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR001180 Citron

    Graphical View of Domain Structure for InterPro Entry Q92918

    ProtoNet protein and cluster: Q92918

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAP4K1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M4K1_HUMAN, Q92918
    Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal
    pathway. May play a role in hematopoietic lineage decisions and growth regulation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for MAP4K1:
    mitogen-activated kinase kinase kinase kinase 1,nuclear,predominantly expressed in hematopoietic cells,binding
    MAP3K1 (MEKK1) activating the JNK/SAPK kinase pathway

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS8824585
    GO:0004674protein serine/threonine kinase activity IDA8824585
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding IPI17474147
         
    Find genes that share ontologies with MAP4K1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MAP4K1:
     Increased viability with 4OH t 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Map4k1):
     hematopoietic system  immune system 

    Find genes that share phenotypes with MAP4K1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MAP4K1: Map4k1tm1Ssaw Map4k1tm1Tht

       genOway: Develop your customized and physiologically relevant rodent model for MAP4K1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--

    Find genes that share ontologies with MAP4K1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP4K1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2B cell receptor signaling pathway (KEGG)
    BCR signaling pathway0.42
    TCR Signaling Pathway0.36
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    4TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD4+ T cells0.64
    5Kit Receptor Signaling Pathway
    Signaling events mediated by Stem cell factor receptor (c-Kit)0.37


    Find genes that share SuperPaths with MAP4K1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP4K1
        TGF-Beta Pathway
    JNK Pathway
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP4K1
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for MAP4K1
        Signal transduction JNK pathway

    Selected BioSystems Pathways for MAP4K1 (see all 10)
        MAPK signaling pathway
    Insulin Signaling
    B Cell Receptor Signaling Pathway
    TCR Signaling Pathway
    Prostate Cancer


    1 Kegg Pathway  (Kegg details for MAP4K1):
        MAPK signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP4K1: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP4K1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP4K1 (Q929181, 2, 3 ENSP000003800664) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-881,EBI-375543 MINT-8110527 MINT-7213035 I2D: score=5 STRING: ENSP00000361423
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-881,EBI-79464 MINT-8112075 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191741, 2, 3, ENSP000002440074EBI-881,EBI-79387 MINT-8112639 I2D: score=3 STRING: ENSP00000244007
    CRKP461081, 3, ENSP000003005744EBI-881,EBI-886 I2D: score=5 STRING: ENSP00000300574
    CRKLP461091, 3, ENSP000003463004EBI-881,EBI-910 I2D: score=5 STRING: ENSP00000346300
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000185activation of MAPKKK activity IC11053428
    GO:0006468protein phosphorylation IDA8824585
    GO:0006950response to stress IDA8824585
    GO:0007257activation of JUN kinase activity TAS8824585
    GO:0018105peptidyl-serine phosphorylation IDA11053428

    Find genes that share ontologies with MAP4K1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for MAP4K1 (see all 19)     About this table
    CompoundAction CAS #
    AZD6244 (Selumetinib)Potent, selective, and ATP-uncompetitive MEK inhibitor--
    AZD8330orally active, selective MEK inhibitor[869357-68-6]
    BIX 02188MEK5-selective inhibitor[1094614-84-2]
    BIX 02189blocks MEK5 and ERK5 catalytic activity[1094614-85-3]
    Cobimetinibselective inhibitor of MEK[934660-93-2]
    MEK inhibitorPotent MEK inhibitor, Antitumor agent[334951-92-7]
    MEK162 (ARRY-162, ARRY-438162)orally available inhibitor of MEK1/2[606143-89-9]
    PD0325901MEK inhibitor[391210-10-9]
    PD184352 (CI-1040)Selective MEK inhibitor[212631-79-3]
    PD318088inhibit MEK-1 and MEK-2[391210-00-7]

    Browse Tocris compounds for MAP4K1 (M4K1)

    3 HMDB Compounds for MAP4K1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    3 Novoseek inferred chemical compound relationships for MAP4K1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 64.9 15 9346925 (3), 9891069 (1), 9820741 (1), 15364934 (1) (see all 8)
    serine 51.8 10 9346925 (1), 9891069 (1), 9820741 (1), 15364934 (1) (see all 7)
    tyrosine 22.9 11 9346925 (3), 11279207 (2), 15743830 (1)



    Find genes that share compounds with MAP4K1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAP4K1 gene (2 alternative transcripts): 
    NM_001042600.2  NM_007181.5  

    Unigene Cluster for MAP4K1:

    Mitogen-activated protein kinase kinase kinase kinase 1
    Hs.95424  [show with all ESTs]
    Unigene Representative Sequence: NM_007181
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593196 ENST00000591517 ENST00000586296 ENST00000589130 ENST00000396857(uc002oix.1 uc002oiy.1)
    ENST00000591210 ENST00000591921 ENST00000588938 ENST00000585583 ENST00000589002
    ENST00000592888 ENST00000591707 ENST00000592225 ENST00000588083 ENST00000587300
    ENST00000423454(uc010xug.2)
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      QuantiFast Probe-based Assays in human, mouse, rat MAP4K1

    Additional mRNA sequence: 

    AK303267.1 U66464.1 

    10 DOTS entries:

    DT.100748776  DT.99993411  DT.97785383  DT.100720540  DT.97843110  DT.100748775  DT.40117714  DT.97825790 
    DT.121471144  DT.97792486 

    Selected AceView cDNA sequences (see all 115):

    AL561215 AW575048 BQ073002 BG389576 CR590852 AW408358 BQ064376 CR597185 
    BX345201 CR599547 AL560823 BM479454 AA749288 CD623848 BM665397 BQ430312 
    BQ441919 BQ437081 BG397984 BG397271 BM693263 T50313 BQ639344 BQ061208 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                          -     -                 -                                                                           
    SP2:                                                  -                                                                           
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for MAP4K1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP4K1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAP4K1 Expression
    About this image


    MAP4K1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MAP4K1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP4K1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.95424

    UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918
    Tissue specificity: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also
    expressed at very low levels in lung, kidney, mammary glands and small intestine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP4K1: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Hematopoiesis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4K1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP4K1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map4k11 , 5 mitogen-activated protein kinase kinase kinase kinase more1, 5 84.41(n)1
    85.84(a)1
      7 (16.94 cM)5
    264111  NM_008279.21  NP_032305.21 
     289828545 
    lizard
    (Anolis carolinensis)
    Reptilia MAP4K16
    mitogen-activated protein kinase kinase kinase kin...
    55(a)
    1 ↔ 1
    GL343427.1(738666-785974)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia map4k11 mitogen-activated protein kinase kinase kinase kinase more 57.69(n)
    55.24(a)
      100495539  XM_002939249.2  XP_002939295.2 
    zebrafish
    (Danio rerio)
    Actinopterygii MAP4K16
    mitogen-activated protein kinase kinase kinase kin...
    65(a)
    1 ↔ 1
    15(46872584-46894317) ENSDARG00000088216
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70973 protein amino acid phosphorylation
    receptor signaling more
    52(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea gck-26
    Protein GCK-2 (gck-2) mRNA, complete cds
    35(a)
    1 → many
    V(6788454-6792665) WBGene00022603
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIC16
    Protein kinase of the PAK/Ste20 family, required f...
    17(a)
    1 → many
    VIII(316572-319814) YHR102W


    ENSEMBL Gene Tree for MAP4K1 (if available)
    TreeFam Gene Tree for MAP4K1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP4K1 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K32  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    Selected SIMAP similar genes for MAP4K1 using alignment to 6 protein entries:     M4K1_HUMAN (see all proteins) (see all similar genes):
    COQ5    MAP4K5    MAP4K2    MAP4K3    CDKL4    MAPK3
    MST4    STK25    MAP4K4    STK3    ATF1    STK4
    STK24    PAK1    PAK2    MYO3A    PAK4    PHKG2

    Find genes that share paralogs with MAP4K1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP4K1 (see all 733)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407424
    A metastatic melanoma sample4--see VAR_0407422 S F mis40--------
    rs1399628281,2
    --39078737(+) CCTGAA/TGGGGG 2 -- int10--------
    rs1888248371,2
    --39078767(+) AAAGGA/GCAAGG 2 -- int10--------
    rs38486211,2
    F,H--39078851(+) GATGTC/TATGGC 2 -- int15Minor allele frequency- T:0.00MN NS EA 602
    rs1869156781,2
    --39078862(+) CTTGTA/GGGCTG 2 -- int10--------
    rs1897567781,2
    --39078915(+) TAAGCA/GGGGAG 2 -- int10--------
    rs1454143731,2
    --39079068(+) GCTCAC/TGCTTG 2 -- int10--------
    rs1471986911,2
    --39079071(+) CATGCC/TTGTAA 2 -- int10--------
    rs1995464311,2
    C--39079098(+) GCCAA-/GGGGGG 2 -- int10--------
    rs1814438471,2
    C--39079122(+) GGTCAC/GGAGTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for MAP4K1 (39078281 - 39109522 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MAP4K1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833828CNV Loss17160897
    dgv3858n71CNV Loss21882294
    nsv833824CNV Loss17160897
    nsv833826CNV Loss17160897
    nsv833827CNV Gain17160897
    nsv470140CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP4K1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP4K1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601983    OMIM disorders: --


    Find genes that share disorders with MAP4K1           About GenesLikeMe

    1 Novoseek inferred disease relationship for MAP4K1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 19141650 (2)


    Export disorders for MAP4K1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP4K1 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with MAP4K1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. (PubMed id 8824585)1, 2, 3, 9 Hu M.C.-T.... Tan T.-H. (Genes Dev. 1996)
    2. Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase. (PubMed id 9891069)1, 9 Ling P....Tan T.H. (Mol. Cell. Biol. 1999)
    3. Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. (PubMed id 15364934)1, 9 Zhou G....Tan T.H. (J. Biol. Chem. 2004)
    4. Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling. (PubMed id 11279207)1, 9 Ling P....Tan T.H. (J. Biol. Chem. 2001)
    5. Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. (PubMed id 19141650)1, 9 Wang H....Wang H. (Cancer Res. 2009)
    6. Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1). (PubMed id 10602493)1, 9 Chen Y.R....Tan T.H. (Oncogene 1999)
    7. Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1. (PubMed id 15743830)1, 9 Arnold R....Kiefer F. (Mol. Cell. Biol. 2005)
    8. Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes. (PubMed id 11313918)1, 9 Ma W....Liu M. (Oncogene 2001)
    9. Activation of hematopoietic progenitor kinase-1 by erythropoietin. (PubMed id 10233887)1, 9 Nagata Y....Todokoro K. (Blood 1999)
    10. Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells. (PubMed id 19706536)1, 9 Brenner D....Arnold R. (Proc. Natl. Acad. Sci. U.S.A. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11184 HGNC: 6863 AceView: MAP4K1 Ensembl:ENSG00000104814 euGenes: HUgn11184
    ECgene: MAP4K1 Kegg: 11184 H-InvDB: MAP4K1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAP4K1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP4K1 gene:
    Search GeneIP for patents involving MAP4K1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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