Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAP4K1 Gene

Aliases for MAP4K1 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 2 3
  • HPK1 3 4 6
  • Hematopoietic Progenitor Kinase 1 2 3
  • MAPK/ERK Kinase Kinase Kinase 1 3 4
  • MEK Kinase Kinase 1 3 4
  • EC 2.7.11.1 4 63
  • MEKKK 1 3 4
  • Hematopoietic Progenitor Kinase 4
  • EC 2.7.11 63

External Ids for MAP4K1 Gene

Summaries for MAP4K1 Gene

GeneCards Summary for MAP4K1 Gene

MAP4K1 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for MAP4K1 Gene

  • Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.

Gene Wiki entry for MAP4K1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP4K1 Gene

Genomics for MAP4K1 Gene

Genomic Location for MAP4K1 Gene

Start:
38,587,640 bp from pter
End:
38,618,882 bp from pter
Size:
31,243 bases
Orientation:
Minus strand

Genomic View for MAP4K1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP4K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4K1 Gene

Regulatory Elements for MAP4K1 Gene

Proteins for MAP4K1 Gene

  • Protein details for MAP4K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92918-M4K1_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase kinase 1
    Protein Accession:
    Q92918
    Secondary Accessions:

    Protein attributes for MAP4K1 Gene

    Size:
    833 amino acids
    Molecular mass:
    91296 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MAP3K1. Interacts with FBXW8.

    Alternative splice isoforms for MAP4K1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP4K1 Gene

Proteomics data for MAP4K1 Gene at MOPED

Selected DME Specific Peptides for MAP4K1 Gene

Post-translational modifications for MAP4K1 Gene

  • Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.
  • Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys139

Other Protein References for MAP4K1 Gene

Domains for MAP4K1 Gene

Gene Families for MAP4K1 Gene

HGNC:
  • MAP4K :Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases
IUPHAR :

Protein Domains for MAP4K1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92918

UniProtKB/Swiss-Prot:

M4K1_HUMAN
Domain:
  • Contains 1 CNH domain.:
    • Q92918
  • Contains 1 protein kinase domain.:
    • Q92918
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.:
    • Q92918
genes like me logo Genes that share domains with MAP4K1: view

Function for MAP4K1 Gene

Molecular function for MAP4K1 Gene

GENATLAS Biochemistry: mitogen-activated kinase kinase kinase kinase 1,nuclear,predominantly expressed in hematopoietic cells,binding MAP3K1 (MEKK1) activating the JNK/SAPK kinase pathway
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.

Enzyme Numbers (IUBMB) for MAP4K1 Gene

Gene Ontology (GO) - Molecular Function for MAP4K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 8824585
GO:0004674 protein serine/threonine kinase activity IDA 8824585
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 17474147
GO:0005524 ATP binding IDA 8824585
genes like me logo Genes that share ontologies with MAP4K1: view

Phenotypes for MAP4K1 Gene

MGI mutant phenotypes for MAP4K1:
inferred from 2 alleles
GenomeRNAi human phenotypes for MAP4K1:
genes like me logo Genes that share phenotypes with MAP4K1: view

Animal Models for MAP4K1 Gene

MGI Knock Outs for MAP4K1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for MAP4K1 Gene

Localization for MAP4K1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP4K1 Gene COMPARTMENTS Subcellular localization image for MAP4K1 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAP4K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MAP4K1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP4K1 Gene

Pathways for MAP4K1 Gene

genes like me logo Genes that share pathways with MAP4K1: view

Pathways by source for MAP4K1 Gene

1 GeneGo (Thomson Reuters) pathway for MAP4K1 Gene
3 Qiagen pathways for MAP4K1 Gene
1 Cell Signaling Technology pathway for MAP4K1 Gene

Gene Ontology (GO) - Biological Process for MAP4K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IC 11053428
GO:0006468 protein phosphorylation IDA 8824585
GO:0006950 response to stress IDA 8824585
GO:0007257 activation of JUN kinase activity TAS 8824585
GO:0008283 cell proliferation IMP 24362026
genes like me logo Genes that share ontologies with MAP4K1: view

Compounds for MAP4K1 Gene

(19) ApexBio Compounds for MAP4K1 Gene

Compound Action Cas Number
AZD6244 (Selumetinib) Potent, selective, and ATP-uncompetitive MEK inhibitor
AZD8330 orally active, selective MEK inhibitor [869357-68-6]
BIX 02188 MEK5-selective inhibitor [1094614-84-2]
BIX 02189 blocks MEK5 and ERK5 catalytic activity [1094614-85-3]
Cobimetinib selective inhibitor of MEK [934660-93-2]
MEK inhibitor Potent MEK inhibitor, Antitumor agent. [334951-92-7]
MEK162 (ARRY-162, ARRY-438162) orally available inhibitor of MEK1/2 [606143-89-9]
PD0325901 MEK inhibitor [391210-10-9]
PD184352 (CI-1040) Selective MEK inhibitor [212631-79-3]
PD318088 inhibit MEK-1 and MEK-2. [391210-00-7]
PD98059 Inhibitor of MKK/MEK. [167869-21-8]
Pimasertib (AS-703026) highly selective and potent noncompetitive inhibitor of MEK1 and MEK2 [1236699-92-5]
PLX-4720 Potent and selective inhibitor of BRAF with V600E mutation [918505-84-7]
SCH772984 novel, potent and ATP-competitive inhibition of ERK1 and ERK2 [942183-80-4]
SL-327 Selective inhibitor of MEK1 and MEK2 [305350-87-2]
Trametinib (GSK1120212) Potent and selective MEK1 and MEK2 inhibitor [871700-17-3]
Trametinib DMSO solvate reversible, selective, allosteric MEK1/MEK2 kinase activity inhibitor [1187431-43-1]
U0126-EtOH Potent, selective, and uncompetitive MEK1/2 inhibitor [1173097-76-1]
Vemurafenib (PLX4032, RG7204) Potent and selective inhibitor of BRAF with V600E mutation [918504-65-1]

(3) HMDB Compounds for MAP4K1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(3) Novoseek inferred chemical compound relationships for MAP4K1 Gene

Compound -log(P) Hits PubMed IDs
threonine 64.9 10
serine 51.8 7
tyrosine 22.9 6
genes like me logo Genes that share compounds with MAP4K1: view

Transcripts for MAP4K1 Gene

Unigene Clusters for MAP4K1 Gene

Mitogen-activated protein kinase kinase kinase kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for MAP4K1 Gene

GeneLoc Exon Structure for
MAP4K1
ECgene alternative splicing isoforms for
MAP4K1

Expression for MAP4K1 Gene

mRNA expression in normal human tissues for MAP4K1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP4K1 Gene

This gene is overexpressed in Whole Blood (9.0), Spleen (8.5), and Small Intestine - Terminal Ileum (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP4K1 Gene

SOURCE GeneReport for Unigene cluster for MAP4K1 Gene Hs.95424

mRNA Expression by UniProt/SwissProt for MAP4K1 Gene

Q92918-M4K1_HUMAN
Tissue specificity: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine.
genes like me logo Genes that share expressions with MAP4K1: view

Orthologs for MAP4K1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP4K1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP4K1 35
  • 99.47 (n)
  • 99.88 (a)
MAP4K1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP4K1 35
  • 89.8 (n)
  • 92.8 (a)
MAP4K1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP4K1 35
  • 89.8 (n)
  • 92.93 (a)
MAP4K1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map4k1 35
  • 84.41 (n)
  • 85.84 (a)
Map4k1 16
Map4k1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP4K1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP4K1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map4k1 35
  • 84.98 (n)
  • 87.06 (a)
lizard
(Anolis carolinensis)
Reptilia MAP4K1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map4k1 35
  • 57.69 (n)
  • 55.24 (a)
zebrafish
(Danio rerio)
Actinopterygii MAP4K1 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hppy 36
  • 29 (a)
OneToMany
CG7097 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea gck-2 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIC1 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for MAP4K1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP4K1 Gene

ENSEMBL:
Gene Tree for MAP4K1 (if available)
TreeFam:
Gene Tree for MAP4K1 (if available)

Paralogs for MAP4K1 Gene

Paralogs for MAP4K1 Gene

genes like me logo Genes that share paralogs with MAP4K1: view

Variants for MAP4K1 Gene

Sequence variations from dbSNP and Humsavar for MAP4K1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs750437 -- 38,613,810(-) CCCCG(A/G)GATCC intron-variant
rs750438 -- 38,613,735(-) GTGTC(G/T)CTTGA intron-variant
rs1978443 -- 38,600,393(-) ACAGT(C/T)GGGCA intron-variant
rs1978444 -- 38,600,389(-) TTGGG(C/G)AGAGA intron-variant
rs2080987 -- 38,591,347(-) ttcat(C/T)atggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP4K1 Gene

Variant ID Type Subtype PubMed ID
nsv470140 CNV Gain 18288195
dgv3858n71 CNV Loss 21882294
nsv833824 CNV Loss 17160897
nsv833826 CNV Loss 17160897
nsv833827 CNV Gain 17160897
nsv833828 CNV Loss 17160897

Relevant External Links for MAP4K1 Gene

HapMap Linkage Disequilibrium report
MAP4K1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4K1 Gene

Disorders for MAP4K1 Gene

(1) Novoseek inferred disease relationships for MAP4K1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2
genes like me logo Genes that share disorders with MAP4K1: view

No data available for UniProtKB/Swiss-Prot for MAP4K1 Gene

Publications for MAP4K1 Gene

  1. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. (PMID: 8824585) Hu M.C.-T. … Tan T.-H. (Genes Dev. 1996) 2 3 4 23
  2. SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1. (PMID: 9346925) Anafi M. … Pawson T. (J. Biol. Chem. 1997) 3 23
  3. The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. (PMID: 9788432) Oehrl W. … Feller S.M. (Oncogene 1998) 3 23
  4. Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase. (PMID: 9891069) Ling P. … Tan T.H. (Mol. Cell. Biol. 1999) 3 23
  5. Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade. (PMID: 10224067) Zhou G. … Tan T.H. (J. Biol. Chem. 1999) 3 23

Products for MAP4K1 Gene

Sources for MAP4K1 Gene

Back to Top

Content