Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAP4 Gene

Aliases for MAP4 Gene

  • Microtubule-Associated Protein 4 2 3
  • MAP-4 3 4

External Ids for MAP4 Gene

Previous GeneCards Identifiers for MAP4 Gene

  • GC03M047698
  • GC03M047175
  • GC03M047852
  • GC03M047853
  • GC03M047867

Summaries for MAP4 Gene

Entrez Gene Summary for MAP4 Gene

  • The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for MAP4 Gene

MAP4 (Microtubule-Associated Protein 4) is a Protein Coding gene. Diseases associated with MAP4 include ovarian clear cell adenocarcinoma and insomnia, fatal familial. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and Transcription_P53 signaling pathway. GO annotations related to this gene include poly(A) RNA binding and microtubule binding. An important paralog of this gene is MAP2.

UniProtKB/Swiss-Prot for MAP4 Gene

  • Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

Gene Wiki entry for MAP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP4 Gene

Genomics for MAP4 Gene

Regulatory Elements for MAP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAP4 Gene

47,850,690 bp from pter
48,089,279 bp from pter
238,590 bases
Minus strand

Genomic View for MAP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4 Gene

Proteins for MAP4 Gene

  • Protein details for MAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microtubule-associated protein 4
    Protein Accession:
    Secondary Accessions:
    • Q13082
    • Q59FT2
    • Q68D74
    • Q6ZUW9
    • Q86V26
    • Q96A76
    • Q96NS9

    Protein attributes for MAP4 Gene

    1152 amino acids
    Molecular mass:
    121005 Da
    Quaternary structure:
    • Interacts with SEPT2; this interaction impedes tubulin-binding.
    • Sequence=BAD92614.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP4 Gene

neXtProt entry for MAP4 Gene

Proteomics data for MAP4 Gene at MOPED

Post-translational modifications for MAP4 Gene

  • Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.
  • Ubiquitination at Lys 346
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MAP4 Gene

Domains & Families for MAP4 Gene

Protein Domains for MAP4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 Tau/MAP repeats.
  • Contains 4 Tau/MAP repeats.
genes like me logo Genes that share domains with MAP4: view

No data available for Gene Families for MAP4 Gene

Function for MAP4 Gene

Molecular function for MAP4 Gene

GENATLAS Biochemistry:
microtubule-associated protein 4,non neuronal
UniProtKB/Swiss-Prot Function:
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

Gene Ontology (GO) - Molecular Function for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 1905296
GO:0005515 protein binding IPI 17474147
GO:0008017 microtubule binding IBA --
GO:0015631 tubulin binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MAP4: view
genes like me logo Genes that share phenotypes with MAP4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP4 Gene

Localization for MAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP4 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for MAP4 Gene COMPARTMENTS Subcellular localization image for MAP4 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 1905296
GO:0005886 plasma membrane IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with MAP4: view

Pathways & Interactions for MAP4 Gene

genes like me logo Genes that share pathways with MAP4: view

Pathways by source for MAP4 Gene

1 PharmGKB pathway for MAP4 Gene
1 GeneGo (Thomson Reuters) pathway for MAP4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for MAP4 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007052 mitotic spindle organization IMP 21822276
GO:0031175 neuron projection development IBA --
GO:0051012 microtubule sliding IMP 21822276
GO:0051294 establishment of spindle orientation IMP 21822276
GO:0051301 cell division IMP 21822276
genes like me logo Genes that share ontologies with MAP4: view

Drugs & Compounds for MAP4 Gene

(9) Drugs for MAP4 Gene - From: FDA Approved Drugs, NovoSeek, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Target Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1792
Paclitaxel Approved Pharma Target Tubulin and Bcl2 inhibitor, Taxanes 2505
Abraxane Approved October 2012 Pharma Taxanes 0
taxol Approved August 1997 Pharma Agonist 0
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1525

(1) Additional Compounds for MAP4 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAP4: view

Transcripts for MAP4 Gene

Unigene Clusters for MAP4 Gene

Microtubule-associated protein 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4 Gene

No ASD Table

Relevant External Links for MAP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP4 Gene

mRNA expression in normal human tissues for MAP4 Gene

mRNA differential expression in normal tissues according to GTEx for MAP4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.2) and Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for MAP4 Gene

This gene is overexpressed in Bone marrow stromal cell (13.6) and Amniocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP4 Gene

SOURCE GeneReport for Unigene cluster for MAP4 Gene Hs.517949

genes like me logo Genes that share expression patterns with MAP4: view

Protein tissue co-expression partners for MAP4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAP4 Gene

Orthologs for MAP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAP4 35
  • 80.14 (n)
  • 70.25 (a)
MAP4 36
  • 66 (a)
(Canis familiaris)
Mammalia MAP4 35
  • 83.29 (n)
  • 74.49 (a)
MAP4 36
  • 68 (a)
(Mus musculus)
Mammalia Map4 35
  • 76.54 (n)
  • 65.08 (a)
Map4 16
Map4 36
  • 58 (a)
(Rattus norvegicus)
Mammalia Map4 35
  • 72.77 (n)
  • 61.27 (a)
(Monodelphis domestica)
Mammalia MAP4 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
(Pan troglodytes)
Mammalia MAP4 36
  • 91 (a)
(Gallus gallus)
Aves MAP4 36
  • 24 (a)
(Anolis carolinensis)
Reptilia MAP4 36
  • 21 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1102 35
(Danio rerio)
Actinopterygii MAP4 (1 of 3) 36
  • 24 (a)
MAP4 (2 of 3) 36
  • 71 (a)
MAP4 (3 of 3) 36
  • 18 (a)
fruit fly
(Drosophila melanogaster)
Insecta tau 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea ptl-1 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11294 36
  • 19 (a)
Species with no ortholog for MAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAP4 Gene

Gene Tree for MAP4 (if available)
Gene Tree for MAP4 (if available)

Paralogs for MAP4 Gene

Paralogs for MAP4 Gene

genes like me logo Genes that share paralogs with MAP4: view

Variants for MAP4 Gene

Sequence variations from dbSNP and Humsavar for MAP4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs20565 -- 47,928,244(-) GTGGT(C/T)GATCC reference, synonymous-codon
rs172768 -- 47,902,439(-) ctcgg(C/T)ctccc intron-variant
rs184388 -- 47,898,136(-) TGAAT(C/T)TGTCT intron-variant
rs319680 -- 47,856,817(-) TGCTG(C/T)AGCAG intron-variant
rs319681 -- 47,878,750(-) gacca(A/G)cctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP4 Gene

Variant ID Type Subtype PubMed ID
nsv834679 CNV Loss 17160897
nsv508916 CNV Insertion 20534489
esv2725244 CNV Deletion 23290073
esv2725245 CNV Deletion 23290073
esv2676938 CNV Deletion 23128226
esv24589 CNV Loss 19812545
esv2660438 CNV Deletion 23128226
nsv876760 CNV Gain 21882294
nsv834681 CNV Loss 17160897

Variation tolerance for MAP4 Gene

Residual Variation Intolerance Score: 26.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.28; 98.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4 Gene

Disorders for MAP4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAP4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian clear cell adenocarcinoma
insomnia, fatal familial
  • fatal familial insomnia
- elite association
Search MAP4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP4 Gene

Publications for MAP4 Gene

  1. Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau. (PMID: 1905296) Chapin S.J. … Bulinski J.C. (J. Cell Sci. 1991) 2 23 67
  2. The p38/MAPK pathway regulates microtubule polymerization through phosphorylation of MAP4 and Op18 in hypoxic cells. (PMID: 19915797) Hu J.Y. … Huang Y.S. (Cell. Mol. Life Sci. 2010) 23 67
  3. Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles. (PMID: 19536824) Schmitt-Ulms G. … Mandelkow E.M. (Cell Motil. Cytoskeleton 2009) 23 67
  4. Overexpression of class III beta-tubulin predicts good response to taxane-based chemotherapy in ovarian clear cell adenocarcinoma. (PMID: 19228748) Aoki D. … Kuwano M. (Clin. Cancer Res. 2009) 23 67
  5. Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis. (PMID: 19411072) Grinkevich V.V. … Selivanova G. (Cancer Cell 2009) 23 67

Products for MAP4 Gene

Sources for MAP4 Gene

Back to Top