External Ids for MAP4 Gene
Previous GeneCards Identifiers for MAP4 Gene
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for MAP4 Gene
MAP4 (Microtubule-Associated Protein 4) is a Protein Coding gene. Diseases associated with MAP4 include ovarian clear cell adenocarcinoma and insomnia, fatal familial. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and Transcription_P53 signaling pathway. GO annotations related to this gene include poly(A) RNA binding and microtubule binding. An important paralog of this gene is MAP2.
UniProtKB/Swiss-Prot for MAP4 Gene
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.