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MAP4 Gene

protein-coding   GIFtS: 65
GCID: GC03M047892

Microtubule-Associated Protein 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule-Associated Protein 41 2
MAP-42 3

External Ids:    HGNC: 68621   Entrez Gene: 41342   Ensembl: ENSG000000478497   OMIM: 1571325   UniProtKB: P278163   

Export aliases for MAP4 gene to outside databases

Previous GC identifers: GC03M047698 GC03M047175 GC03M047852 GC03M047853 GC03M047867


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP4 Gene:
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a
domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and
microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to
counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with
this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this
protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Aug 2008)

GeneCards Summary for MAP4 Gene:
MAP4 (microtubule-associated protein 4) is a protein-coding gene. Diseases associated with MAP4 include clear cell adenocarcinoma, and ovarian clear cell adenocarcinoma. GO annotations related to this gene include microtubule binding and structural molecule activity. An important paralog of this gene is MAPT.

UniProtKB/Swiss-Prot: MAP4_HUMAN, P27816
Function: Non-neuronal microtubule-associated protein. Promotes microtubule assembly

Gene Wiki entry for MAP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP4 gene promoter:
         AML1a   GATA-3   MAZR   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Nkx2-5   POU3F2   E47   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP4 promoter sequence
   Search Chromatin IP Primers for MAP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

MAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M047892:  view genomic region     (about GC identifiers)

Start:
47,892,180 bp from pter      End:
48,130,769 bp from pter
Size:
238,590 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAP4_HUMAN, P27816 (See protein sequence)
Recommended Name: Microtubule-associated protein 4  
Size: 1152 amino acids; 121005 Da
Subunit: Interacts with SEPT2; this interaction impedes tubulin-binding
Sequence caution: Sequence=BAD92614.1; Type=Erroneous initiation;
Secondary accessions: Q13082 Q59FT2 Q68D74 Q6ZUW9 Q86V26 Q96A76 Q96NS9
Alternative splicing: 7 isoforms:  P27816-1   P27816-2   P27816-3   P27816-4   P27816-5   P27816-6   P27816-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP4: NX_P27816

Explore proteomics data for MAP4 at MOPED

Post-translational modifications: 

  • Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or
    MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787
    negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and
    Ser-3381
  • Ubiquitination2 at Lys346, Lys498, Lys946
  • Modification sites at PhosphoSitePlus

  • See MAP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001127836.1  NP_002366.2  NP_112147.2  

    ENSEMBL proteins: 
     ENSP00000416743   ENSP00000379083   ENSP00000407602   ENSP00000353375   ENSP00000409731  
     ENSP00000334770   ENSP00000373242   ENSP00000415689   ENSP00000402767   ENSP00000397414  
     ENSP00000415130   ENSP00000373243   ENSP00000264724  

    MAP4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MAP4
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    OriGene Custom Protein Services for MAP4
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    Novus Biologicals MAP4 Protein
    Novus Biologicals MAP4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP4

    MAP4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP4
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    Novus Biologicals MAP4 Antibodies
    Abcam antibodies for MAP4
    Cloud-Clone Corp. Antibodies for MAP4
    ThermoFisher Antibody for MAP4
    LSBio Antibodies in human, mouse, rat for MAP4

    MAP4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAP4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP4
    Cloud-Clone Corp. CLIAs for MAP4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027323 MAP4
     IPR027324 MAP2/MAP4/Tau
     IPR001084 MAP_tubulin-bd_rpt

    Graphical View of Domain Structure for InterPro Entry P27816

    ProtoNet protein and cluster: P27816

    1 Blocks protein domain: IPB001084 Tubulin-binding Tau protein

    UniProtKB/Swiss-Prot: MAP4_HUMAN, P27816
    Similarity: Contains 4 Tau/MAP repeats


    MAP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAP4_HUMAN, P27816
    Function: Non-neuronal microtubule-associated protein. Promotes microtubule assembly

         Genatlas biochemistry entry for MAP4:
    microtubule-associated protein 4,non neuronal

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity TAS1905296
    GO:0005515protein binding IPI17474147
    GO:0008017microtubule binding IEA--
    GO:0015631tubulin binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    MAP4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAP4:
     Decreased cilium length after   Decreased p24 protein expressi  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Map4):
     normal 

    MAP4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP4

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP4:
    hsa-mir-16-5p (MIRT031936), hsa-mir-100-5p (MIRT048440), hsa-mir-23b-3p (MIRT046357), hsa-mir-328-3p (MIRT043764), hsa-mir-331-3p (MIRT043550), hsa-mir-34a-5p (MIRT025500), hsa-mir-103a-3p (MIRT027147), hsa-let-7b-5p (MIRT052234), hsa-mir-196a-5p (MIRT048277), hsa-mir-551b-3p (MIRT040524), hsa-mir-92a-3p (MIRT049316), hsa-mir-484 (MIRT042202), hsa-mir-339-5p (MIRT042741)

    Block miRNA regulation of human, mouse, rat MAP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP4 (see all 71):
    hsa-miR-300 hsa-miR-15a hsa-miR-519a hsa-miR-3613-3p hsa-miR-130b hsa-miR-761 hsa-miR-3688-3p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidMAP4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP4
    Predesigned siRNA for gene silencing in human, mouse, rat MAP4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP4

    Clone
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    OriGene clones in human, mouse for MAP4 (see all 20)
    OriGene ORF clones in mouse, rat for MAP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAP4 (NM_001134364)
    Sino Biological Human cDNA Clone for MAP4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAP4
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAP4_HUMAN, P27816: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    plasma membrane4
    nucleus3
    vacuole3
    lysosome2
    mitochondrion2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex TAS1905296
    GO:0005886plasma membrane IDA--
    GO:0015630microtubule cytoskeleton IDA--

    MAP4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP4 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    2Irinotecan Pathway, Pharmacokinetics
    Taxane Pathway, Pharmacokinetics0.30
    3Transcription P53 signaling pathway
    Transcription P53 signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MAP4
        Transcription P53 signaling pathway


    1 PharmGKB Pathway for MAP4
        Taxane Pathway, Pharmacokinetics

        Pathway & Disease-focused RT2 Profiler PCR Array including MAP4: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP4 (P278161, 2, 3 ENSP000003533754) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8112087 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112651 I2D: score=3 STRING: ENSP00000244007
    GSK3BP498412, 3, ENSP000003248064MINT-8257427 I2D: score=2 STRING: ENSP00000324806
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007052mitotic spindle organization IMP--
    GO:0051012microtubule sliding IMP--
    GO:0051294establishment of spindle orientation IMP--
    GO:0051301cell division IMP--

    MAP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    9 ApexBio Compounds for MAP4     About this table
    CompoundAction CAS #
    7-xylosyltaxoltaxol (Paclitaxel) derivative[90332-66-4]
    ColchicineColchicine, a tubulin Inhibitor[64-86-8]
    D-64131novel inhibitor of Tubulin polymerization[74588-78-6]
    Docetaxel Trihydrateinhibitor of depolymerisation of microtubules[148408-66-6]
    Mc-MMADPotent tubulin inhibitor[1401963-15-2]
    MMADPotent tubulin inhibitor[203849-91-6]
    Monomethyl auristatin EAntimitotic agent[474645-27-7]
    PodophyllotoxinActions Inhibits microtubule assembly[518-28-5]
    Vc-MMADantibody drug conjugate[1401963-17-4]

    Browse Tocris compounds for MAP4

    2 DrugBank Compounds for MAP4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DocetaxelDocetaxel anhydrous (see all 4)114977-28-5target--18068131
    Paclitaxel7-epi-Paclitaxel (see all 8)33069-62-4target--18068131

    7 Novoseek inferred chemical compound relationships for MAP4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    map4 98.9 247 8636213 (13), 7876309 (11), 7857940 (10), 9398320 (9) (see all 44)
    nocodazole 57.9 3 7876309 (1), 8636213 (1), 7622564 (1)
    paclitaxel 56.2 7 10446979 (1), 19228748 (1), 9365275 (1)
    vinblastine 48.4 1 11479219 (1)
    doxorubicin 29.3 3 12006519 (2), 10446979 (1)
    alanine 9.32 1 11683421 (1)
    glutamate 0 1 11683421 (1)



    MAP4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAP4 gene (5 alternative transcripts): 
    NM_001134364.1  NM_002375.4  NM_030885.3  NM_001134365.1  NM_030884.3  

    Unigene Cluster for MAP4:

    Microtubule-associated protein 4
    Hs.517949  [show with all ESTs]
    Unigene Representative Sequence: NM_002375
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429422 ENST00000395734(uc003csb.2 uc003csc.3) ENST00000426837(uc003csd.2 uc003csf.3)
    ENST00000360240(uc011bbf.1) ENST00000420772(uc011bbe.1) ENST00000335271
    ENST00000477765 ENST00000383736 ENST00000462206 ENST00000497735(uc003cse.1)
    ENST00000482752 ENST00000423088 ENST00000434267 ENST00000439356(uc003csg.3)
    ENST00000468075 ENST00000441748 ENST00000383737 ENST00000264724(uc003crw.2 uc003crx.2 uc003csa.3 uc003crz.4)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAP4 (see all 71):
    hsa-miR-300 hsa-miR-15a hsa-miR-519a hsa-miR-3613-3p hsa-miR-130b hsa-miR-761 hsa-miR-3688-3p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidMAP4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAP4
    Predesigned siRNA for gene silencing in human, mouse, rat MAP4
    Clone
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    OriGene clones in human, mouse for MAP4 (see all 20)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAP4 (NM_001134364)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAP4
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP4
      QuantiTect SYBR Green Assays in human, mouse, rat MAP4
      QuantiFast Probe-based Assays in human, mouse, rat MAP4

    Additional mRNA sequence: 

    AB209377.1 AF052156.1 AF454938.1 AK054577.1 AK054696.1 AK091042.1 AK125245.1 AK297242.1 
    AK299854.1 AK307606.1 AL831878.1 BC008715.2 BC012794.2 BC015149.2 BC019229.1 BC048200.1 
    BC051843.1 BC067228.1 CR749544.1 M64571.1 U19727.1 

    Selected DOTS entries (see all 59):

    DT.95110755  DT.100010178  DT.95304334  DT.92470575  DT.101974243  DT.453401  DT.102838986  DT.95110754 
    DT.100886285  DT.100039266  DT.75156787  DT.92061737  DT.403200  DT.100886271  DT.95110756  DT.120893743 
    DT.100886266  DT.100886272  DT.120893584  DT.120893960  DT.319927  DT.92470471  DT.92470484  DT.100843940 

    Selected AceView cDNA sequences (see all 740):

    AI860120 BG035922 NM_002375 AI431432 BM971250 CA392535 NM_030885 AI268907 
    BQ009082 R35257 CD675443 AL041485 AI217051 AW296440 AA206922 BM989571 
    BQ003507 CB107648 AI380591 AA488179 BM911823 BQ073535 AI926495 AI150159 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCTGTTGT
    MAP4 Expression
    About this image


    MAP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             Ventral/hypothalamic-like neurons
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Neurons
             Ventral/hypothalamic-like neurons
    MAP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517949
        Pathway & Disease-focused RT2 Profiler PCR Array including MAP4: 
              Cytoskeleton Regulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAP4
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP4
    QuantiTect SYBR Green Assays in human, mouse, rat MAP4
    QuantiFast Probe-based Assays in human, mouse, rat MAP4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAP4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map41 , 5 microtubule-associated protein 41, 5 76.54(n)1
    65.08(a)1
      9 (59.83 cM)5
    177581  NM_001205332.11  NP_001192261.11 
     1099314605 
    chicken
    (Gallus gallus)
    Aves MAP46
    microtubule-associated protein 4
    24(a)
    1 ↔ 1
    2(677526-705016)
    lizard
    (Anolis carolinensis)
    Reptilia MAP46
    microtubule-associated protein 4
    21(a)
    1 ↔ 1
    GL343332.1(1140640-1225010)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.11022 Xenopus laevis mRNA for XMAP4, complete cds 79.56(n)    AB021705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii MAP4 (2 of 3)6
    MAP4 (1 of 3)6
    (see all 3)
    microtubule-associated protein 4
    (see all 3)
    71(a)
    24(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    Zv9_NA405(9249-11519) ENSDARG00000075464
    2(23611810-23687140) ENSDARG00000068745
    fruit fly
    (Drosophila melanogaster)
    Insecta tau6
    tau
    17(a)
    1 → many
    3R(23466365-23482718)
    worm
    (Caenorhabditis elegans)
    Secernentea ptl-16
    Protein PTL-1, isoform b
    17(a)
    1 → many
    III(763810-771390) WBGene00004212


    ENSEMBL Gene Tree for MAP4 (if available)
    TreeFam Gene Tree for MAP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP4 gene
    MAPT2  MAP22  
    3 SIMAP similar genes for MAP4 using alignment to 13 protein entries:     MAP4_HUMAN (see all proteins):
    DKFZp547H1810    4R-MAP2    MAPT

    MAP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP4 (see all 4106)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10611381,2
    C,F--47892236(-) TGATTC/G/TTGTTG 4 -- ut313NA 124
    rs1416429111,2
    --47892345(+) GGTCCC/TGGCCT 2 -- ut310--------
    rs1864037291,2
    --47892351(+) GGCCTG/TCTCAG 2 -- ut310--------
    rs1912592551,2
    --47892355(+) TTCTCA/GGGTGC 2 -- ut310--------
    rs717032941,2
    C--47892377(+) GATCC-/CTTTTTGA 2 -- cds10--------
    rs777203201,2
    C,F--47892383(+) TTTGAG/AGGAAC 2 -- ut311Minor allele frequency- A:0.25WA 118
    rs115481441,2
    C,F--47892431(-) GGTGGC/ACCAAG 2 -- ut311Minor allele frequency- A:0.03NA 120
    rs1823047871,2
    --47892450(+) ACCTTA/TGGCCA 2 -- ut310--------
    rs1411572331,2
    C--47892514(+) GGACA-/GACGACGC 2 -- cds10--------
    rs758318091,2
    C,F--47892574(+) TCCTGA/TCTACG 2 -- ut311Minor allele frequency- T:0.06WA 118

    HapMap Linkage Disequilibrium report for MAP4 (47892180 - 48130769 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MAP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725244CNV Deletion23290073
    esv2725245CNV Deletion23290073
    esv2676938CNV Deletion23128226
    esv2660438CNV Deletion23128226
    nsv508916CNV Insertion20534489
    nsv834681CNV Loss17160897
    nsv834679CNV Loss17160897
    esv24589CNV Loss19812545
    nsv876760CNV Gain21882294

    Human Gene Mutation Database (HGMD): MAP4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP4
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 157132    OMIM disorders: --

    Selected diseases for MAP4 (see all 21):    
    About MalaCards
    clear cell adenocarcinoma    ovarian clear cell adenocarcinoma    lissencephaly    brain disease
    neuronitis    diffuse large b-cell lymphoma    b-cell lymphomas    adenocarcinoma
    neuroblastoma    schizophrenia    tonsillitis    hypoxia
    alzheimer's disease    hiv-1    prostatitis    prostate cancer
    leukemia    breast cancer    thyroiditis    cerebritis

    2 diseases from the University of Copenhagen DISEASES database for MAP4:
    Alzheimer's disease     Lissencephaly

    MAP4 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for MAP4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiac hypertrophy 19.7 2 12388311 (1), 15528234 (1)
    leukemia 1.51 1 12890753 (1)
    breast cancer 0 3 12006519 (2), 18528466 (1)
    tumors 0 1 12006519 (1)

    Genetic Association Database (GAD): MAP4
    Human Genome Epidemiology (HuGE) Navigator: MAP4 (3 documents)

    Export disorders for MAP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP4 gene, integrated from 10 sources (see all 137):
    (articles sorted by number of sources associating them with MAP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau. (PubMed id 1905296)1, 2, 3, 9 Chapin S.J. and Bulinski J.C. (J. Cell Sci. 1991)
    2. Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains. (PubMed id 7857940)1, 2, 9 Chapin S.J.... Bulinski J.C. (Biochemistry 1995)
    3. Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. (PubMed id 16093351)1, 2, 9 Kremer B.E.... Macara I.G. (Mol. Biol. Cell 2005)
    4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
    5. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    6. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4134 HGNC: 6862 AceView: MAP4 Ensembl:ENSG00000047849 euGenes: HUgn4134
    ECgene: MAP4 H-InvDB: MAP4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAP4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAP4 gene:
    Search GeneIP for patents involving MAP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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