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Aliases for MAP4 Gene

Aliases for MAP4 Gene

  • Microtubule-Associated Protein 4 2 3
  • MAP-4 3 4

External Ids for MAP4 Gene

Previous GeneCards Identifiers for MAP4 Gene

  • GC03M047698
  • GC03M047175
  • GC03M047852
  • GC03M047853
  • GC03M047867

Summaries for MAP4 Gene

Entrez Gene Summary for MAP4 Gene

  • The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for MAP4 Gene

MAP4 (Microtubule-Associated Protein 4) is a Protein Coding gene. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and Transcription_P53 signaling pathway. GO annotations related to this gene include structural molecule activity and microtubule binding. An important paralog of this gene is MAP2.

UniProtKB/Swiss-Prot for MAP4 Gene

  • Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

Gene Wiki entry for MAP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP4 Gene

Genomics for MAP4 Gene

Regulatory Elements for MAP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAP4 Gene

Start:
47,850,690 bp from pter
End:
48,089,279 bp from pter
Size:
238,590 bases
Orientation:
Minus strand

Genomic View for MAP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP4 Gene

Proteins for MAP4 Gene

  • Protein details for MAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27816-MAP4_HUMAN
    Recommended name:
    Microtubule-associated protein 4
    Protein Accession:
    P27816
    Secondary Accessions:
    • Q13082
    • Q59FT2
    • Q68D74
    • Q6ZUW9
    • Q86V26
    • Q96A76
    • Q96NS9

    Protein attributes for MAP4 Gene

    Size:
    1152 amino acids
    Molecular mass:
    121005 Da
    Quaternary structure:
    • Interacts with SEPT2; this interaction impedes tubulin-binding.
    SequenceCaution:
    • Sequence=BAD92614.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP4 Gene

neXtProt entry for MAP4 Gene

Proteomics data for MAP4 Gene at MOPED

Post-translational modifications for MAP4 Gene

  • Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.
  • Ubiquitination at Lys346, Lys498, and Lys946
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MAP4 Gene

Domains for MAP4 Gene

Protein Domains for MAP4 Gene

Graphical View of Domain Structure for InterPro Entry

P27816

UniProtKB/Swiss-Prot:

MAP4_HUMAN :
  • P27816
Similarity:
  • Contains 4 Tau/MAP repeats.
genes like me logo Genes that share domains with MAP4: view

No data available for Gene Families for MAP4 Gene

Function for MAP4 Gene

Molecular function for MAP4 Gene

GENATLAS Biochemistry: microtubule-associated protein 4,non neuronal
UniProtKB/Swiss-Prot Function: Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

Gene Ontology (GO) - Molecular Function for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 1905296
GO:0005515 protein binding IPI 17474147
GO:0008017 microtubule binding IEA --
GO:0015631 tubulin binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MAP4: view

Phenotypes for MAP4 Gene

genes like me logo Genes that share phenotypes with MAP4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP4

Clone Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAP4 Gene

Localization for MAP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP4 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP4 Gene COMPARTMENTS Subcellular localization image for MAP4 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 4
nucleus 3
vacuole 3
lysosome 2
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 1905296
GO:0005886 plasma membrane IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with MAP4: view

Pathways for MAP4 Gene

genes like me logo Genes that share pathways with MAP4: view

Pathways by source for MAP4 Gene

1 PharmGKB pathway for MAP4 Gene
1 GeneGo (Thomson Reuters) pathway for MAP4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007052 mitotic spindle organization IMP 21822276
GO:0051012 microtubule sliding IMP 21822276
GO:0051294 establishment of spindle orientation IMP 21822276
GO:0051301 cell division IMP 21822276
genes like me logo Genes that share ontologies with MAP4: view

Compounds for MAP4 Gene

(9) ApexBio Compounds for MAP4 Gene

Compound Action Cas Number
7-xylosyltaxol taxol (Paclitaxel) derivative [90332-66-4]
Colchicine Colchicine, a tubulin Inhibitor [64-86-8]
D-64131 novel inhibitor of Tubulin polymerization [74588-78-6]
Docetaxel Trihydrate inhibitor of depolymerisation of microtubules [148408-66-6]
Mc-MMAD Potent tubulin inhibitor [1401963-15-2]
MMAD Potent tubulin inhibitor [203849-91-6]
Monomethyl auristatin E Antimitotic agent [474645-27-7]
Podophyllotoxin Actions Inhibits microtubule assembly [518-28-5]
Vc-MMAD antibody drug conjugate. [1401963-17-4]

(2) Drugbank Compounds for MAP4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Docetaxel
  • Docetaxel anhydrous
114977-28-5 target
Paclitaxel
  • 7-epi-Paclitaxel
33069-62-4 target

(7) Novoseek inferred chemical compound relationships for MAP4 Gene

Compound -log(P) Hits PubMed IDs
map4 98.9 171
nocodazole 57.9 3
paclitaxel 56.2 3
vinblastine 48.4 1
doxorubicin 29.3 3
genes like me logo Genes that share compounds with MAP4: view

Transcripts for MAP4 Gene

Unigene Clusters for MAP4 Gene

Microtubule-associated protein 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP4

Clone Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP4 Gene

No ASD Table

Relevant External Links for MAP4 Gene

GeneLoc Exon Structure for
MAP4
ECgene alternative splicing isoforms for
MAP4

Expression for MAP4 Gene

mRNA expression in normal human tissues for MAP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.2) and Muscle - Skeletal (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP4 Gene

SOURCE GeneReport for Unigene cluster for MAP4 Gene Hs.517949

genes like me logo Genes that share expressions with MAP4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MAP4 Gene

Orthologs for MAP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP4 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP4 35
  • 80.14 (n)
  • 70.25 (a)
MAP4 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP4 35
  • 83.29 (n)
  • 74.49 (a)
MAP4 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map4 35
  • 76.54 (n)
  • 65.08 (a)
Map4 16
Map4 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP4 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Map4 35
  • 72.77 (n)
  • 61.27 (a)
chicken
(Gallus gallus)
Aves MAP4 36
  • 24 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP4 36
  • 21 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1102 35
zebrafish
(Danio rerio)
Actinopterygii MAP4 (1 of 3) 36
  • 24 (a)
OneToMany
MAP4 (2 of 3) 36
  • 71 (a)
OneToMany
MAP4 (3 of 3) 36
  • 18 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta tau 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ptl-1 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11294 36
  • 19 (a)
OneToOne
Species with no ortholog for MAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAP4 Gene

ENSEMBL:
Gene Tree for MAP4 (if available)
TreeFam:
Gene Tree for MAP4 (if available)

Paralogs for MAP4 Gene

Paralogs for MAP4 Gene

genes like me logo Genes that share paralogs with MAP4: view

Variants for MAP4 Gene

Sequence variations from dbSNP and Humsavar for MAP4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs20565 -- 47,928,244(-) GTGGT(C/T)GATCC reference, synonymous-codon
rs172768 -- 47,902,439(-) ctcgg(C/T)ctccc intron-variant
rs184388 -- 47,898,136(-) TGAAT(C/T)TGTCT intron-variant
rs319680 -- 47,856,817(-) TGCTG(C/T)AGCAG intron-variant
rs319681 -- 47,878,750(-) gacca(A/G)cctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP4 Gene

Variant ID Type Subtype PubMed ID
nsv834679 CNV Loss 17160897
nsv508916 CNV Insertion 20534489
esv2725244 CNV Deletion 23290073
esv2725245 CNV Deletion 23290073
esv2676938 CNV Deletion 23128226
esv24589 CNV Loss 19812545
esv2660438 CNV Deletion 23128226
nsv876760 CNV Gain 21882294
nsv834681 CNV Loss 17160897

Relevant External Links for MAP4 Gene

HapMap Linkage Disequilibrium report
MAP4
Human Gene Mutation Database (HGMD)
MAP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP4 Gene

Disorders for MAP4 Gene

(2) University of Copenhagen DISEASES for MAP4 Gene

(4) Novoseek inferred disease relationships for MAP4 Gene

Disease -log(P) Hits PubMed IDs
cardiac hypertrophy 19.7 2
leukemia 1.51 1
breast cancer 0 3
tumors 0 1

Relevant External Links for MAP4

Genetic Association Database (GAD)
MAP4
Human Genome Epidemiology (HuGE) Navigator
MAP4
genes like me logo Genes that share disorders with MAP4: view

No data available for UniProtKB/Swiss-Prot for MAP4 Gene

Publications for MAP4 Gene

  1. Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau. (PMID: 1905296) Chapin S.J. … Bulinski J.C. (J. Cell Sci. 1991) 2 3 4 23
  2. Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains. (PMID: 7857940) Chapin S.J. … Bulinski J.C. (Biochemistry 1995) 3 4 23
  3. Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. (PMID: 16093351) Kremer B.E. … Macara I.G. (Mol. Biol. Cell 2005) 3 4 23
  4. Interphase and monoastral-mitotic phenotypes of overexpressed MAP4 are modulated by free tubulin concentrations. (PMID: 12890753) Holmfeldt P. … Gullberg M. (J. Cell. Sci. 2003) 3 23
  5. Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters. (PMID: 14527689) Punga T. … AkusjAorvi G. (FEBS Lett. 2003) 3 23

Products for MAP4 Gene

Sources for MAP4 Gene

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