MAP4 Gene

Aliases
for MAP4 gene

Previous GC identifers: GC03M047698 GC03M047175 GC03M047852 GC03M047853 GC03M047867

Summaries
for MAP4 gene

Genomic Views
for MAP4 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_022517.18  

SwitchGear Promoter luciferase reporter plasmid: MAP4 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP4

MAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M047892:  view genomic region     (about GC identifiers)

Proteins
for MAP4 gene

Explore the universe of human proteins at neXtProt for MAP4: NX_P27816

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MAP4 OriGene Custom Protein Services for MAP4
	GenScript Custom Purified and Recombinant Proteins Services for MAP4
	Novus Biologicals MAP4 Protein Novus Biologicals MAP4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAP4

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP4
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for MAP4
	GenScript Superior Antibodies for MAP4
	Novus Biologicals MAP4 Antibodies
	Search for Antibodies for MAP4 at Abcam
	Uscn Antibodies for MAP4
	ThermoFisher Antibody for MAP4

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MAP4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MAP4

Protein Domains /
Families
for MAP4 gene

ProtoNet protein and cluster: P27816

Function
for MAP4 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 5): MAP4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP4
		8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP4 (see all 71):
		hsa-miR-300 hsa-miR-15a hsa-miR-519a hsa-miR-3613-3p hsa-miR-130b hsa-miR-761 hsa-miR-3688-3p hsa-miR-130a*
		SwitchGear 3'UTR luciferase reporter plasmid: MAP4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP4 (see all 4) OriGene shRNA RFP: MAP4 OriGene siRNA: MAP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MAP4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP4 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP4 (see all 6) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): MAP4 (NM_001134364)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MAP4
		Search LifeMap BioReagents cell lines for MAP4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Map4)

Pathways & Interactions
for MAP4 gene

	Super-pathway	contained gene-specific pathways
1	Transcription_P53 signaling pathway	Transcription_P53 signaling pathway 1.00 Transcription P53 signaling pathway 0.98
2	Cytoskeleton remodeling Neurofilaments	Cytoplasmic microtubules 0.32
3	Irinotecan Pathway, Pharmacokinetics	Taxane Pathway, Pharmacokinetics 0.30

2 EMD Millipore Pathways for MAP4

	Cytoplasmic microtubules
	Transcription P53 signaling pathway

1 GeneGo (Thomson Reuters) Pathway for MAP4

Transcription P53 signaling pathway

1 PharmGKB Pathway for MAP4

Taxane Pathway, Pharmacokinetics

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for MAP4 gene

Transcripts
for MAP4 gene

Expression
for MAP4 gene

MAP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCTGTTGT

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Ventral/hypothalamic-like neurons (Generation of midbra...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP4

Orthologs
for MAP4 gene

Paralogs
for MAP4 gene

Paralogs for MAP4 gene

MAPT²  MAP2²  

3 SIMAP similar genes for MAP4 using alignment to 13 protein entries:     MAP4_HUMAN (see all proteins):

DKFZp547H1810    4R-MAP2    MAPT

MAP4 for paralogs           About GeneDecksing

Genomic Variants
for MAP4 gene

10/3318 NCBI SNPs in MAP4 are shown (see all 3318)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs105371801,2	C,	--	47891745(+)	TCCCC-/AAAGAGG	4	--	ds5001		1		NA	2
rs23078721,2	C,F,	--	47891863(-)	CTCTTTCTT/-           GGTGA	4	--	ds5001		4		EU NA EA	342
rs1168113441,2	F,	--	47891928(+)	TCTCGG/ATACCC	4	--	ds5001		1		WA	118
rs1445153901,2		--	47891974(+)	GTAGTG/TTTGGA	4	--	ds5001		0	--	--	--	--
rs798028311,2	C,	--	47892062(+)	AGGGCC/TATGTG	4	--	ds5001		0	--	--	--	--
rs1178944181,2	F,	--	47892122(+)	CTGAGC/TTGAGG	4	--	ds5001		1		EA	120
rs1388935231,2	C,	--	47892164(+)	ACGAG-/ACACAGA	4	--	ds5001		0	--	--	--	--
rs2016087201,2	C	--	47892164(+)	AACGAC/GACAGA	4	--	ds5001		0	--	--	--	--
rs23078741,2	C	--	47892167(-)	GCTTC-/TGTGTCT	4	--	ds5001		6		EU NA EA CSA	346
rs788176621,2	C,F,	--	47892183(+)	GCCTGC/TGTGAT	4	--	ut31 ds5001		1		EA	120

HapMap Linkage Disequilibrium report for MAP4 (47892180 - 48130769 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAP4
     1 CNV: 63463

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP4

DNA2.0 Custom Variant and Variant Library Synthesis for MAP4

Disorders / Diseases
for MAP4 gene

13 diseases for MAP4

4 Novoseek disease relationships for MAP4 gene    About this table

Publications
for MAP4 gene

PubMed articles for MAP4 gene, integrated from 9 sources (see all 122): (articles sorted by number of sources associating them with MAP4)

Utopia: connect your pdf to the dynamic world of online information

1. Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau. (PubMed id 1905296)^{1, 2, 3, 9} Chapin S.J. and Bulinski J.C. (1991)
2. Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains. (PubMed id 7857940)^{1, 2, 9} Chapin S.J.... Bulinski J.C. (1995)
3. Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4. (PubMed id 16093351)^{1, 2, 9} Kremer B.E.... Macara I.G. (2005)
4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
7. An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
10. Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization. (PubMed id 10791892)^{1, 2} Kitazawa H....Hisanaga S. (2000)

External Searches for MAP4 gene

Genome Databases showing MAP4 gene

Other Databases showing MAP4 gene

Specialized Databases showing MAP4 gene

Products
for MAP4 gene