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Aliases for MAP3K9 Gene

Aliases for MAP3K9 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 9 2 3 5
  • EC 2.7.11.25 4 63
  • PRKE1 3 4
  • MLK1 3 4
  • Mixed Lineage Kinase 1 (Tyr And Ser/Thr Specificity) 3
  • Mixed Lineage Kinase 1 4
  • EC 2.7.11 63
  • MEKK9 3

External Ids for MAP3K9 Gene

Previous HGNC Symbols for MAP3K9 Gene

  • MLK1

Previous GeneCards Identifiers for MAP3K9 Gene

  • GC14M068701
  • GC14M064991
  • GC14M069184
  • GC14M070264
  • GC14M071194
  • GC14M051363
  • GC14M071189

Summaries for MAP3K9 Gene

GeneCards Summary for MAP3K9 Gene

MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9) is a Protein Coding gene. Diseases associated with MAP3K9 include Retroperitoneal Neuroblastoma. Among its related pathways are ERK Signaling and WNT Signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is KSR1.

UniProtKB/Swiss-Prot for MAP3K9 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Gene Wiki entry for MAP3K9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K9 Gene

Genomics for MAP3K9 Gene

Regulatory Elements for MAP3K9 Gene

Enhancers for MAP3K9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAP3K9 on UCSC Golden Path with GeneCards custom track

Promoters for MAP3K9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAP3K9 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP3K9 Gene

Chromosome:
14
Start:
70,722,526 bp from pter
End:
70,809,534 bp from pter
Size:
87,009 bases
Orientation:
Minus strand

Genomic View for MAP3K9 Gene

Genes around MAP3K9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K9 Gene

Proteins for MAP3K9 Gene

  • Protein details for MAP3K9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80192-M3K9_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 9
    Protein Accession:
    P80192
    Secondary Accessions:
    • A3KN85
    • Q0D2G7
    • Q6EH31
    • Q9H2N5

    Protein attributes for MAP3K9 Gene

    Size:
    1104 amino acids
    Molecular mass:
    121895 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAI11408.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP3K9 Gene

    Alternative splice isoforms for MAP3K9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K9 Gene

Proteomics data for MAP3K9 Gene at MOPED

Post-translational modifications for MAP3K9 Gene

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP3K9 (MLK1)

Domains & Families for MAP3K9 Gene

Suggested Antigen Peptide Sequences for MAP3K9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80192

UniProtKB/Swiss-Prot:

M3K9_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K9: view

Function for MAP3K9 Gene

Molecular function for MAP3K9 Gene

GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 9
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=62 uM for ATP {ECO:0000269 PubMed:11325962}; KM=7 uM for myelin basic protein (MBP) as substrate {ECO:0000269 PubMed:11325962};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Homodimerization via the leucine zipper domains is required for autophosphorylation of multiple sites in the activation loop and subsequent activation. Autophosphorylation at Thr-312 is the key step in activation of MAP3K9/MLK1 and is required for full phosphorylation. Autophosphorylation at Thr-304 and Ser-308 have been shown to be of secondary importance in the activation of MAP3K9/MLK1. CEP-1347 and many indolocarbazole analogs have been shown to act as inhibitors of MAP3K9/MLK1 activity.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Enzyme Numbers (IUBMB) for MAP3K9 Gene

Gene Ontology (GO) - Molecular Function for MAP3K9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IDA 15610029
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0042803 protein homodimerization activity ISS 8195146
genes like me logo Genes that share ontologies with MAP3K9: view
genes like me logo Genes that share phenotypes with MAP3K9: view

Animal Models for MAP3K9 Gene

MGI Knock Outs for MAP3K9:

Animal Model Products

CRISPR Products

miRNA for MAP3K9 Gene

miRTarBase miRNAs that target MAP3K9

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K9 Gene

Localization for MAP3K9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP3K9 Gene COMPARTMENTS Subcellular localization image for MAP3K9 gene
Compartment Confidence
cytosol 4
nucleus 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAP3K9 Gene

Pathways & Interactions for MAP3K9 Gene

genes like me logo Genes that share pathways with MAP3K9: view

Pathways by source for MAP3K9 Gene

1 Cell Signaling Technology pathway for MAP3K9 Gene
2 BioSystems pathways for MAP3K9 Gene

Gene Ontology (GO) - Biological Process for MAP3K9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IEA,IDA 15610029
GO:0006915 apoptotic process IEA --
GO:0007256 activation of JNKK activity ISS --
genes like me logo Genes that share ontologies with MAP3K9: view

No data available for SIGNOR curated interactions for MAP3K9 Gene

Drugs & Compounds for MAP3K9 Gene

(4) Drugs for MAP3K9 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one Experimental Pharma Target 0
URMC-099 Pharma 0
Magnesium Nutra 0

(1) Additional Compounds for MAP3K9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for MAP3K9 Gene

Compound Action Cas Number
URMC-099 1229582-33-5
genes like me logo Genes that share compounds with MAP3K9: view

Transcripts for MAP3K9 Gene

Unigene Clusters for MAP3K9 Gene

Mitogen-activated protein kinase kinase kinase 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K9 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: - - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for MAP3K9 Gene

GeneLoc Exon Structure for
MAP3K9
ECgene alternative splicing isoforms for
MAP3K9

Expression for MAP3K9 Gene

mRNA expression in normal human tissues for MAP3K9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K9 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.6) and Brain - Cerebellum (x5.6).

Protein differential expression in normal tissues from HIPED for MAP3K9 Gene

This gene is overexpressed in NK cells (31.0), Lung (30.5), and Blymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP3K9 Gene



SOURCE GeneReport for Unigene cluster for MAP3K9 Gene Hs.445496

mRNA Expression by UniProt/SwissProt for MAP3K9 Gene

P80192-M3K9_HUMAN
Tissue specificity: Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
genes like me logo Genes that share expression patterns with MAP3K9: view

Protein tissue co-expression partners for MAP3K9 Gene

Primer Products

Orthologs for MAP3K9 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP3K9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP3K9 35
  • 91.82 (n)
  • 96.04 (a)
MAP3K9 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP3K9 35
  • 92.78 (n)
  • 97.32 (a)
MAP3K9 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map3k9 35
  • 90.41 (n)
  • 96.04 (a)
Map3k9 16
Map3k9 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAP3K9 35
  • 98.75 (n)
  • 98.31 (a)
MAP3K9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map3k9 35
  • 89.86 (n)
  • 95.75 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP3K9 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K9 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC425792 35
  • 76.83 (n)
  • 83.7 (a)
MAP3K9 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP3K9 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k9 35
  • 70.24 (n)
  • 74.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.31756 35
zebrafish
(Danio rerio)
Actinopterygii LOC560639 35
  • 64.49 (n)
  • 66.56 (a)
map3k9 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta slpr 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K11D12.10b 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8999 36
  • 35 (a)
OneToMany
Species with no ortholog for MAP3K9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP3K9 Gene

ENSEMBL:
Gene Tree for MAP3K9 (if available)
TreeFam:
Gene Tree for MAP3K9 (if available)

Paralogs for MAP3K9 Gene

genes like me logo Genes that share paralogs with MAP3K9: view

Variants for MAP3K9 Gene

Sequence variations from dbSNP and Humsavar for MAP3K9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_040698 A metastatic melanoma sample
VAR_040699 A gastric adenocarcinoma sample
rs56196343 - 70,742,428(+) TCACC(C/T)GGGGC reference, missense
rs34322726 - 70,734,475(+) GCTTA(C/T)ATCCA reference, missense
rs8593 -- 70,722,705(+) AAGAA(C/T)CTGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAP3K9 Gene

Variant ID Type Subtype PubMed ID
esv2748848 CNV Deletion 23290073
nsv525761 CNV Loss 19592680

Variation tolerance for MAP3K9 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAP3K9 Gene

Disorders for MAP3K9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP3K9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retroperitoneal neuroblastoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

M3K9_HUMAN
  • Note=May play a role in esophageal cancer susceptibility and/or development.

Relevant External Links for MAP3K9

Genetic Association Database (GAD)
MAP3K9
Human Genome Epidemiology (HuGE) Navigator
MAP3K9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K9
genes like me logo Genes that share disorders with MAP3K9: view

No data available for Genatlas for MAP3K9 Gene

Publications for MAP3K9 Gene

  1. Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop. (PMID: 15610029) Durkin J.T. … Meyer S.L. (Biochemistry 2004) 3 4 23 67
  2. Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer. (PMID: 23836671) Fawdar S. … Brognard J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  3. Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. (PMID: 22197930) Stark M.S. … Hayward N.K. (Nat. Genet. 2012) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3

Products for MAP3K9 Gene

Sources for MAP3K9 Gene

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