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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K9 Gene

protein-coding   GIFtS: 59
GCID: GC14M071189

mitogen-activated protein kinase kinase kinase 9


(Previous symbol: MLK1)
 Explore 9 diseases affiliated with
MAP3K9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP3K9    

Aliases
for MAP3K9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 91 2     EC 2.7.11.253 8
MLK11 2 3 5     Mixed Lineage Kinase 1 (Tyr And Ser/Thr Specificity)2
PRKE11 2 3     Mixed Lineage Kinase 13
MEKK91 2     EC 2.7.118

External Ids:    HGNC: 68611   Entrez Gene: 42932   Ensembl: ENSG000000064327   OMIM: 6001365   UniProtKB: P801923   

Export aliases for MAP3K9 gene to outside databases

Previous GC identifers: GC14M068701 GC14M064991 GC14M069184 GC14M070264 GC14M071194 GC14M051363


Summaries
for MAP3K9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: M3K9_HUMAN, P80192
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated,
acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4
and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator
protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including
the release cytochrome c, leading to apoptosis

Gene Wiki entry for MAP3K9


Genomic Views
for MAP3K9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K9 gene promoter:
         SRF   c-Fos   AP-1   SRF (504 AA)   ATF-2   c-Jun   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAP3K9 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP3K9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.2   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.2

MAP3K9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K9 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M071189:  view genomic region     (about GC identifiers)

Start:
 71,189,243 bp from pter      End:
 71,276,251 bp from pter
Size:
 87,009 bases      Orientation:
 minus strand

Proteins
for MAP3K9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: M3K9_HUMAN, P80192 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 9  
Size: 1104 amino acids; 121895 Da
Cofactor: Magnesium
Subunit: Homodimer (By similarity)
Sequence caution: Sequence=AAI11408.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for MAP3K9:
3DTC (3D)    
Secondary accessions: A3KN85 Q0D2G7 Q6EH31 Q9H2N5
Alternative splicing: 2 isoforms:  P80192-1   P80192-4   

Explore the universe of human proteins at neXtProt for MAP3K9: NX_P80192

Post-translational modifications:

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
    • Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-3081
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P80192

    • 4/11 DME Specific Peptides for MAP3K9 (P80192) (see all 11)
     FPRLPDP  SGDEGWW  WMAPEVI  LRAKEKEL 

    MAP3K9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_149132.2  
    ENSEMBL proteins: 
     ENSP00000451612   ENSP00000451263   ENSP00000451038   ENSP00000370649   ENSP00000451921  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAP3K9 Protein
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    Novus Biologicals MAP3K9 Protein
    Novus Biologicals MAP3K9 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAP3K9

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    MAP3K9 for ontologies           About GeneDecksing



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    Assay Products for MAP3K9: 
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    Uscn ELISAs and CLIAs for MAP3K9

    Protein Domains /
    Families
    for MAP3K9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP3K9 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR017441 Protein_kinase_ATP_BS
     IPR016231 MAPKKK9/10/11
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry P80192

    ProtoNet protein and cluster: P80192

    UniProtKB/Swiss-Prot: M3K9_HUMAN, P80192
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH3 domain


    Function
    for MAP3K9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: M3K9_HUMAN, P80192
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.
    Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated,
    acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4
    and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator
    protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including
    the release cytochrome c, leading to apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation of multiple
    sites in the activation loop and subsequent activation. Autophosphorylation at Thr-312 is the key step in activation
    of MAP3K9/MLK1 and is required for full phosphorylation. Autophosphorylation at Thr-304 and Ser-308 have been shown to
    be of secondary importance in the activation of MAP3K9/MLK1. CEP-1347 and many indolocarbazole analogs have been shown
    to act as inhibitors of MAP3K9/MLK1 activity
    Biophysicochemical properties: Kinetic parameters: KM=62 uM for ATP; KM=7 uM for myelin basic protein (MBP) as
    substrate;

         Genatlas biochemistry entry for MAP3K9:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 9

    Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

    miRNA
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    hsa-mir-34a (MIRT005606)

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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K9
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K9 (see all 62):
    hsa-miR-328 hsa-miR-361-5p hsa-miR-1197 hsa-miR-188-5p hsa-miR-15a hsa-miR-106a hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: MAP3K9 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K9 (see all 4)
    OriGene shRNA RFP: MAP3K9
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K9

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K9 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for MAP3K9

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K9

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IDA15610029
    GO:0004706JUN kinase kinase kinase activity ISS--
    GO:0004708MAP kinase kinase activity NAS8477742
    GO:0004709MAP kinase kinase kinase activity ----
    GO:0004713protein tyrosine kinase activity IEA--


    MAP3K9 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MAP3K9:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased colony dispersion (i 

    Animal Models:
         8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Map3k9):
     digestive/alimentary  embryogenesis  mortality/aging  muscle  nervous system 
     normal  renal/urinary system  reproductive system 

    MAP3K9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAP3K9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TGF-Beta Pathway
    		MAPK Family Pathway0.60
    		JNK Pathway0.50
    2MAP Kinase Signaling
    		MAP Kinase Signaling1.00
    3WNT Signaling
    		WNT Signaling1.00
    4NFAT and Cardiac Hypertrophy
    		NFAT and Cardiac Hypertrophy1.00
    5p38 MAPK Signaling Pathway
    		p38 MAPK Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K9 (see all 8)
        STAT3 Pathway
    JNK Pathway
    TNFR2 Pathway
    NFAT and Cardiac Hypertrophy
    MAPK Family Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP3K9
        MAP Kinase Signaling

    2 BioSystems Pathways for MAP3K9 
        p38 MAPK Signaling Pathway
    Insulin Signaling



    MAP3K9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K9

    2 Interacting proteins for MAP3K9 (P801921, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3RF1Q7Z6J03I2D: score=1 
    HSP90AB1P082381EBI-3951604,EBI-352572
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation NAS--


    MAP3K9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP3K9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP3K9

    3 HMDB Compounds for MAP3K9    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for MAP3K9    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about MAP3K9 / M3K9 

    Transcripts
    for MAP3K9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP3K9 gene: 
    NM_033141.2  

    Unigene Clusters for MAP3K9:

    Mitogen-activated protein kinase kinase kinase 9
    Hs.445496  [show with all ESTs], Hs.593542  [show with all ESTs]
    Unigene Representative Sequences: AK123430, NM_033141
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554752(uc010ttk.2 uc001xmk.3 uc001xml.3 uc001xmm.3)
    ENST00000555993 ENST00000553414 ENST00000381250 ENST00000554146 ENST00000554024


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K9
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K9 (see all 62):
    hsa-miR-328 hsa-miR-361-5p hsa-miR-1197 hsa-miR-188-5p hsa-miR-15a hsa-miR-106a hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: MAP3K9 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF251442.1 AK091645.1 AK294571.1 AK299727.1 AK302849.1 AY327900.1 BC033197.1 BC040716.2 
    BC043010.2 BC111407.1 BC133706.1 BX648924.1 

    10 DOTS entries:

    DT.40191219  DT.97779811  DT.97794270  DT.40262434  DT.100745061  DT.40108218  DT.120766806  DT.120766813 
    DT.40124432  DT.75146403 

    24/50 AceView cDNA sequences (see all 50):

    BM713410 BU621199 Z44356 F09502 BE046942 BU621599 BQ058771 CA422985 
    BM678330 AK123430 AA994720 CF529239 BQ012515 AI189167 F04217 BX118545 
    AI867864 AA868268 F07969 F03086 BG325485 F04216 AA846227 AI954727 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K9 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                              
    SP2:                    -     -     -                                             
    SP3:                                -                                             
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for MAP3K9

    Expression
    for MAP3K9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTAGCAGGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MAP3K9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K9

    SOURCE GeneReport for Unigene clusters: Hs.445496 Hs.593542

    UniProtKB/Swiss-Prot: M3K9_HUMAN, P80192
    Tissue specificity: Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin

        SABiosciences Custom PCR Arrays for MAP3K9
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K9
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K9

    Orthologs
    for MAP3K9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP3K9 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC4257921 mitogen-activated protein kinase kinase kinase 9-like 75.71(n)
    81.66(a)    		   425792  XM_003641351.1  XP_003641399.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAP3K96
    		 --
    		 78(a)
    		 1 ↔ 1
    		 1(37516058-37564425)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.317562 Xenopus laevis, clone IMAGE5542423, mRNA 74.86(n)    BC045104.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5606391 similar to Mitogen-activated protein kinase kinase more 64.31(n)
    65.99(a)    		   560639  XM_684036.2  XP_689128.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta slpr6
    		 slipper
    		 29(a)
    		 1 → many
    		 X(8064408-8071187)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G795706
    AT3G469206
    (see all 7)    		 octicosapeptide/Phox/Be.1 domain-containing protei...
    octicosapeptide/Phox/Bem1p domain-containing prote...
    (see all 7)    		 9(a)
    9(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 1(29932578-29938856)
    3(17280430-17284857)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 protein kinase domain containing protein, expresse...
    protein kinase domain containing protein, expresse...
    (see all 5)    		 9(a)
    9(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 6(26398279-26404234)
    7(14722116-14730584)


    ENSEMBL Gene Tree for MAP3K9 (if available)
    TreeFam Gene Tree for MAP3K9 (if available) 

    Paralogs
    for MAP3K9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP3K9 gene
    MAP3K112  MAP3K122  KIAA18042  RAF12  KSR22  KSR12  MOS2  BRAF2  
    MAP3K102  ARAF2  MAP3K72  MAP3K7CL2  TNNI3K2  ZAK2  MAP3K132  ILK2  
    18/27 SIMAP similar genes for MAP3K9 using alignment to 4 protein entries:     M3K9_HUMAN (see all proteins) (see all similar genes):
    BRAF    MAP3K11    MAP3K10    ZAK    ITSN2    PKN2
    MAP3K12    MLK4    ARHGEF7    MAP3K13    MARK4    pk
    DKFZp686M05208    DKFZp564L2416    PRKCH    TXK    ITSN1    RPS6KA2

    MAP3K9 for paralogs           About GeneDecksing



    Genomic Variants
    for MAP3K9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1510 NCBI SNPs in MAP3K9 are shown (see all 1510)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs71568771,2
    		C,--51443080(+) AAGGAG/TCTAGA 1 -- us2k10--------
    rs101488541,2
    		C,F,--51443132(+) TGTCAA/GAGGAC 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs37428471,2
    		C,--51444378(-) CGTTGG/TGGGGG 1 -- us2k1 tfbs33Minor allele frequency- T:0.15NA EA 242
    rs779452471,2
    		F,--51445488(+) GGAACG/TCTGCC 1 -- nc-transcript-variant1Minor allele frequency- T:0.04WA 118
    rs171085601,2
    		C,--51445647(+) GCTGAG/CTTCAC 1 -- nc-transcript-variant3Minor allele frequency- C:0.01NA 142
    rs1395087691,2
    		--71194731(+) GAGGGC/TCACAA 1 -- ds50010--------
    rs128795691,2
    		C,F,H,--71194774(+) ATGTGT/CTCATG 1 -- ds500136Minor allele frequency- C:0.16NS EA NA WA CSA 3308
    rs1502007341,2
    		C,--71194822(+) GCCAC-/AGAACAG 1 -- ds50010--------
    rs1876131601,2
    		--71194890(+) CTGGAA/GTGCAA 1 -- ut310--------
    rs1912235871,2
    		--71194914(+) GCTCAC/TTGCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MAP3K9 (71189243 - 71276251 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAP3K9: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MAP3K9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP3K9 for disorders           About GeneDecksing

    OMIM gene information: 600136    OMIM disorders: --

    UniProtKB/Swiss-Prot: M3K9_HUMAN, P80192
  • Note=May play a role in esophageal cancer susceptibility and/or development

    • 9 diseases for MAP3K9:    About MalaCards
    arachnoid cysts    arachnoiditis    megakaryoblastic leukemia    esophageal cancer
    esophagitis    leukemia    schizophrenia    neuronitis
    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: MAP3K9 (1 document)

    Export disorders for MAP3K9 gene to outside databases

    Publications
    for MAP3K9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K9 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with MAP3K9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop. (PubMed id 15610029)1, 2, 9 Durkin J.T.... Meyer S.L. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. (PubMed id 11416147)1, 2 Xu Z....Greene L.A. (2001)
    4. Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains. (PubMed id 8477742)1, 2 Dorow D.S.... de Kretser T. (1993)
    5. Frequent somatic mutations in MAP3K5 and MAP3K9 in met astatic melanoma identified by exome sequencing. (PubMed id 22197930)1 Stark M.S....Hayward N.K. (2012)
    6. Genome-wide pharmacogenomic study of neurocognition a s an indicator of antipsychotic treatment response in schizophrenia. (PubMed id 21107309)1 McClay J.L....van den Oord E.J. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Repression of the estrogen receptor-alpha transcripti onal activity by the Rho/megakaryoblastic leukemia 1 signaling pathway. (PubMed id 19826002)1 Huet G....Flouriot G. (2009)
    9. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    10. Genomic profiling of 766 cancer-related genes in archived esophageal normal and carcinoma tissues. (PubMed id 18241037)2 Chen J....Fan J.B. (2008)

    External Searches for MAP3K9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAP3K9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4293 HGNC: 6861 AceView: MAP3K9.1 Ensembl:ENSG00000006432 euGenes: HUgn4293
    ECgene: MAP3K9 H-InvDB: MAP3K9

    Other Databases showing MAP3K9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAP3K9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP3K9 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAP3K9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP3K9 gene:
    Search GeneIP for patents involving MAP3K9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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