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Aliases for MAP3K9 Gene

Aliases for MAP3K9 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 9 2 3 5
  • EC 2.7.11.25 4 61
  • PRKE1 3 4
  • MLK1 3 4
  • Mixed Lineage Kinase 1 (Tyr And Ser/Thr Specificity) 3
  • Mixed Lineage Kinase 1 4
  • EC 2.7.11 61
  • MEKK9 3

External Ids for MAP3K9 Gene

Previous HGNC Symbols for MAP3K9 Gene

  • MLK1

Previous GeneCards Identifiers for MAP3K9 Gene

  • GC14M068701
  • GC14M064991
  • GC14M069184
  • GC14M070264
  • GC14M071194
  • GC14M051363
  • GC14M071189

Summaries for MAP3K9 Gene

GeneCards Summary for MAP3K9 Gene

MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9) is a Protein Coding gene. Diseases associated with MAP3K9 include Retroperitoneum Carcinoma and Retroperitoneal Neuroblastoma. Among its related pathways are 4-1BB Pathway and NFAT and Cardiac Hypertrophy. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAP3K10.

UniProtKB/Swiss-Prot for MAP3K9 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Gene Wiki entry for MAP3K9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K9 Gene

Genomics for MAP3K9 Gene

Regulatory Elements for MAP3K9 Gene

Enhancers for MAP3K9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G070781 1.1 FANTOM5 ENCODE dbSUPER 26.4 +27.3 27283 2.2 KLF17 FOS ZNF600 WT1 SP7 MAP3K9 LOC100506411 PIR58438 GC14M070751
GH14G070788 1 Ensembl ENCODE dbSUPER 12.8 +20.1 20080 1.3 POLR2A SMARCA4 FEZF1 MAP3K9 LOC100506411 PIR58438 GC14M070751
GH14G070817 1.2 Ensembl ENCODE 9.9 -8.3 -8267 0.8 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 REST MIER2 ZNF579 MAP3K9 ENSG00000275630
GH14G070784 0.5 ENCODE dbSUPER 21.9 +24.5 24462 1.1 MAP3K9 LOC100506411 GC14M070751 PIR58438
GH14G070807 1 ENCODE 10.2 -0.6 -616 4.8 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZBTB7B YY1 GLIS2 ZNF143 FOS MAP3K9 ENSG00000275630
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP3K9 on UCSC Golden Path with GeneCards custom track

Promoters for MAP3K9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070345 234 2201 HDGF PKNOX1 ARID4B SIN3A ZBTB7B YY1 GLIS2 ZNF143 ZNF263 SP3

Genomic Location for MAP3K9 Gene

Chromosome:
14
Start:
70,722,526 bp from pter
End:
70,809,534 bp from pter
Size:
87,009 bases
Orientation:
Minus strand

Genomic View for MAP3K9 Gene

Genes around MAP3K9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K9 Gene

Proteins for MAP3K9 Gene

  • Protein details for MAP3K9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80192-M3K9_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 9
    Protein Accession:
    P80192
    Secondary Accessions:
    • A3KN85
    • Q0D2G7
    • Q6EH31
    • Q9H2N5

    Protein attributes for MAP3K9 Gene

    Size:
    1104 amino acids
    Molecular mass:
    121895 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAI11408.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP3K9 Gene

    Alternative splice isoforms for MAP3K9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K9 Gene

Selected DME Specific Peptides for MAP3K9 Gene

P80192:
  • HRDLKSSN
  • LAVAYGVA
  • MSAAGTYAWM
  • KKKGRTWGP
  • KQWSSSAPNL
  • LWELLTGE
  • LRAKEKEL
  • FPRLPDP
  • SGDEGWW
  • WMAPEVI
  • QSLTPTHVT

Post-translational modifications for MAP3K9 Gene

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MAP3K9 Gene

Suggested Antigen Peptide Sequences for MAP3K9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80192

UniProtKB/Swiss-Prot:

M3K9_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K9: view

Function for MAP3K9 Gene

Molecular function for MAP3K9 Gene

GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 9
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=62 uM for ATP {ECO:0000269 PubMed:11325962}; KM=7 uM for myelin basic protein (MBP) as substrate {ECO:0000269 PubMed:11325962};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Homodimerization via the leucine zipper domains is required for autophosphorylation of multiple sites in the activation loop and subsequent activation. Autophosphorylation at Thr-312 is the key step in activation of MAP3K9/MLK1 and is required for full phosphorylation. Autophosphorylation at Thr-304 and Ser-308 have been shown to be of secondary importance in the activation of MAP3K9/MLK1. CEP-1347 and many indolocarbazole analogs have been shown to act as inhibitors of MAP3K9/MLK1 activity.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Enzyme Numbers (IUBMB) for MAP3K9 Gene

Gene Ontology (GO) - Molecular Function for MAP3K9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 15610029
GO:0004706 JUN kinase kinase kinase activity ISS,IBA --
GO:0004708 MAP kinase kinase activity NAS 8477742
genes like me logo Genes that share ontologies with MAP3K9: view
genes like me logo Genes that share phenotypes with MAP3K9: view

Animal Models for MAP3K9 Gene

MGI Knock Outs for MAP3K9:

Animal Model Products

CRISPR Products

miRNA for MAP3K9 Gene

miRTarBase miRNAs that target MAP3K9

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K9 Gene

Localization for MAP3K9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K9 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAP3K9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MAP3K9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K9 Gene

Pathways & Interactions for MAP3K9 Gene

genes like me logo Genes that share pathways with MAP3K9: view

Pathways by source for MAP3K9 Gene

1 Cell Signaling Technology pathway for MAP3K9 Gene

Gene Ontology (GO) - Biological Process for MAP3K9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IDA,IEA 15610029
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with MAP3K9: view

No data available for SIGNOR curated interactions for MAP3K9 Gene

Drugs & Compounds for MAP3K9 Gene

(4) Drugs for MAP3K9 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one Experimental Pharma Target 0
URMC-099 Pharma 0
Magnesium Nutra 0

(1) Additional Compounds for MAP3K9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for MAP3K9 Gene

Compound Action Cas Number
URMC-099 1229582-33-5
genes like me logo Genes that share compounds with MAP3K9: view

Drug Products

Transcripts for MAP3K9 Gene

Unigene Clusters for MAP3K9 Gene

Mitogen-activated protein kinase kinase kinase 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K9 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: - - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for MAP3K9 Gene

GeneLoc Exon Structure for
MAP3K9
ECgene alternative splicing isoforms for
MAP3K9

Expression for MAP3K9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP3K9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K9 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.6) and Brain - Cerebellum (x5.6).

Protein differential expression in normal tissues from HIPED for MAP3K9 Gene

This gene is overexpressed in NK cells (31.0), Lung (30.5), and Blymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP3K9 Gene



Protein tissue co-expression partners for MAP3K9 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP3K9 Gene:

MAP3K9

SOURCE GeneReport for Unigene cluster for MAP3K9 Gene:

Hs.445496

mRNA Expression by UniProt/SwissProt for MAP3K9 Gene:

P80192-M3K9_HUMAN
Tissue specificity: Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.

Evidence on tissue expression from TISSUES for MAP3K9 Gene

  • Intestine(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with MAP3K9: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K9 Gene

Orthologs for MAP3K9 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP3K9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP3K9 34 35
  • 98.75 (n)
dog
(Canis familiaris)
Mammalia MAP3K9 34 35
  • 92.78 (n)
cow
(Bos Taurus)
Mammalia MAP3K9 34 35
  • 91.82 (n)
mouse
(Mus musculus)
Mammalia Map3k9 34 16 35
  • 90.41 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP3K9 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map3k9 34
  • 89.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K9 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP3K9 35
  • 77 (a)
OneToOne
LOC425792 34
  • 76.83 (n)
lizard
(Anolis carolinensis)
Reptilia MAP3K9 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k9 34
  • 70.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.31756 34
zebrafish
(Danio rerio)
Actinopterygii LOC560639 34
  • 64.49 (n)
map3k9 35
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta slpr 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K11D12.10b 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8999 35
  • 35 (a)
OneToMany
Species where no ortholog for MAP3K9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP3K9 Gene

ENSEMBL:
Gene Tree for MAP3K9 (if available)
TreeFam:
Gene Tree for MAP3K9 (if available)

Paralogs for MAP3K9 Gene

genes like me logo Genes that share paralogs with MAP3K9: view

Variants for MAP3K9 Gene

Sequence variations from dbSNP and Humsavar for MAP3K9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs773256562 A gastric adenocarcinoma sample 70,742,519(+) CCGAC(A/G)CCGCA reference, missense
VAR_040698 A metastatic melanoma sample
rs1000016470 -- 70,739,118(+) CAAGG(A/G)AAGCT intron-variant
rs1000042102 -- 70,727,459(+) AACGT(A/G)TCTTT utr-variant-3-prime
rs1000089562 -- 70,764,391(+) TGTGT(C/T)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K9 Gene

Variant ID Type Subtype PubMed ID
esv2748848 CNV deletion 23290073
nsv1038007 CNV gain 25217958
nsv1039460 CNV gain 25217958
nsv1118281 CNV deletion 24896259
nsv476825 CNV novel sequence insertion 20440878
nsv525761 CNV loss 19592680

Variation tolerance for MAP3K9 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K9 Gene

Human Gene Mutation Database (HGMD)
MAP3K9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K9 Gene

Disorders for MAP3K9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAP3K9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retroperitoneum carcinoma
  • carcinoma of retroperitoneum
retroperitoneal neuroblastoma
mucocele of salivary gland
  • mucous retention cyst of salivary gland
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

M3K9_HUMAN
  • Note=May play a role in esophageal cancer susceptibility and/or development.

Relevant External Links for MAP3K9

Genetic Association Database (GAD)
MAP3K9
Human Genome Epidemiology (HuGE) Navigator
MAP3K9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K9
genes like me logo Genes that share disorders with MAP3K9: view

No data available for Genatlas for MAP3K9 Gene

Publications for MAP3K9 Gene

  1. Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop. (PMID: 15610029) Durkin J.T. … Meyer S.L. (Biochemistry 2004) 3 4 22 64
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. (PMID: 11416147) Xu Z. … Greene L.A. (Mol. Cell. Biol. 2001) 3 4 64

Products for MAP3K9 Gene

Sources for MAP3K9 Gene

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