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MAP3K8 Gene

protein-coding GIFtS: 65

GC10P030762

mitogen-activated protein kinase kinase kinase 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: COT, ESTF)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C-COT ^³
COT ^², ³, ⁵
EC 2.7.11.25 ^³
EST ^¹, ², ⁵
ESTF ^², ³
FLJ10486 ^²
OTTHUMP00000019392 ^²
OTTHUMP00000019393 ^²
TPL-2 ^³
TPL2 ^², ⁵
Tpl-2 ^¹, ²
c-COT ^¹, ²

Descriptions
COT proto-oncogene serine/threonine-protein kinase ^³
Cancer Osaka thyroid oncogene ^², ³
Ewing sarcoma transformant ^²
Tumor progression locus 2 ^³
cot (cancer Osaka thyroid) oncogene ^²
mitogen-activated protein kinase kinase kinase 8 ^²
proto-oncogene serine/threoine protein kinase ^²
tumor progression locus-2 ^²

External Ids
HGNC: 6860¹
Entrez Gene: 1326²
UniProtKB: P41279³
Ensembl: ENSG00000107968⁷

Search outside databases for aliases for MAP3K8 gene

Previous GC identifers: GC10P030458 GC10P030873 GC10P030726

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAP3K8:

This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a

member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase

and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the

nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha

and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct

involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also

utilize a downstream in-frame translation start codon, and thus produce an isoform containing a

shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.

[provided by RefSeq]

UniProtKB/Swiss-Prot: M3K8_HUMAN, P41279

Function: Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by

stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle.

The longer form has some transforming activity, although it is much weaker than the activated cot

oncoprotein

Gene Wiki entry for MAP3K8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAP3K8 gene

Entrez Gene cytogenetic band: 10p11.23 Ensembl cytogenetic band: 10p11.23 HGNC cytogenetic band: 10p11.2

MAP3K8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P030762: (about GC identifiers)

Start:	30,762,872 bp from pter
End:	30,790,768 bp from pter
Size:	27,897 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_008705.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: M3K8_HUMAN, P41279 (See protein sequence)

Recommended Name: Mitogen-activated protein kinase kinase kinase 8

Size: 467 amino acids; 52925 Da

Cofactor: Magnesium

Subunit: Forms a ternary complex with NFKB1 and TNIP2

Subcellular location: Cytoplasm

Developmental stage: Isoform 1 is activated specifically during the S and G2/M phases of the cell

cycle

Secondary accessions: Q14275 Q5T855 Q9HC81

Alternative initiation: 2 isoforms: P41279-1 P41279-2

Post-translational modifications:

Autophosphorylated. Isoform 1 undergoes phosphorylation mainly on Ser residues, and isoform 2 on

both Ser and Thr residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005195.2

ENSEMBL proteins:

ENSP00000364471 ENSP00000364477 ENSP00000364470 ENSP00000263056

Human Recombinant Proteins

	Invitrogen human recombinant proteins for MAP3K8
	Millipore Purified and/or Recombinant MAP3K8 Protein
	Sigma-Aldrich Proteins for MAP3K8
	R&D Systems Recombinant & Natural Proteins for MAP3K8 (COT)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MAP3K8)
	Human Recombinant Proteins from Abnova (MAP3K8)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	TAS	8226782

About this table

Antibodies for MAP3K8:

	Invitrogen Antibodies for MAP3K8
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MAP3K8
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for MAP3K8 (Cot)
	Antibodies from Abcam (MAP3K8), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAP3K8)
	Novus Biologicals Antibodies for MAP3K8

Assays for MAP3K8:

	Invitrogen Assays for MAP3K8
	Millipore Kits and Assays for the Analysis of MAP3K8
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P41279

ProtoNet protein and cluster: P41279

UniProtKB/Swiss-Prot: M3K8_HUMAN, P41279

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP

kinase kinase kinase subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAP3K8)
		Millipore RNAi Products for the Analysis of MAP3K8 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (MAP3K8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005204

Applied Biosystems Silencer® siRNAs for MAP3K8

Sigma-Aldrich siRNA and siRNA Panels for MAP3K8

Sigma-Aldrich shRNA Panels and shRNA for MAP3K8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MAP3K8
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005204
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005204
untagged cDNA clones in CMV expression vector (see all 2): NM_005204

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005204

UniProtKB/Swiss-Prot: M3K8_HUMAN, P41279

Function: Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by

stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle.

The longer form has some transforming activity, although it is much weaker than the activated cot

oncoprotein

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.25

Genatlas biochemistry entry for MAP3K8:

mitogen-activated protein kinase kinase kinase 8,with two alternatively spliced transcripts

4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Map3k8):

digestive/alimentary

hematopoietic system

immune system

lethality-prenatal/perinatal

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	TAS	8226782
GO:0004709	MAP kinase kinase kinase activity	IEA	--
GO:0005515	protein binding	IPI	15169888

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for MAP3K8 (Your Favorite Gene powered by Ingenuity) (see all 7 )

NF-&kappa
Inositol Phosphate Metabolism
PI3K/AKT Signaling
B Cell Receptor Signaling
IL-12 Signaling and Production in Macrophages

GeneDecks MAP3K8 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for MAP3K8

5/35 Interacting proteins for MAP3K8 (ENSP00000364477³ P41279^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 35 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB2	Q00653²	STRING (score=.759) MINT-47914 MINT-47828 MINT-47833
RELA	Q04206²	STRING (score=.869) MINT-47829 MINT-47834
NFKB1	P19838²	STRING (score=.961) MINT-47827
REL	Q04864²	STRING (score=.892) MINT-47831
TNIP2	Q8NFZ5¹^,²	STRING (score=.991) EBI-354900, EBI-359372 MINT-47826 EBI-354900, EBI-359372 MINT-47826

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	TAS	2072910
GO:0007049	cell cycle	IEA	--
GO:0007165	signal transduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAP3K8
1 Novoseek chemical compound relationship for MAP3K8 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	50.31	1	10669751 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAP3K8)
		Millipore RNAi Products for the Analysis of MAP3K8 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (MAP3K8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005204

Sigma-Aldrich siRNA and siRNA Panels for MAP3K8

Sigma-Aldrich shRNA Panels and shRNA for MAP3K8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005204

REFSEQ mRNAs for MAP3K8 gene:

NM_005204.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005204

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005204
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005204
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005204

Additional cDNA sequence:

AB209539.1 AK290320.1 AK313295.1 BC104833.1 BC113566.1 CR542284.1 CR619928.1 D14497.1

10 DOTS entries:

DT.415680 DT.91797861 DT.92424307 DT.101980928 DT.100773619 DT.100773621 DT.415684 DT.92424295

DT.100686784 DT.121303723

24/122 AceView cDNA sequences (see all 122 ):

BU929720 CR619928 T29129 CF994198 BM848442 BI908729 CB125814 CB124240

CF594092 CA426041 NM_005204 AV659361 BX103131 CD367347 AI042009 CB125233

AA156840 AA677028 CD365718 AI471552 AI362092 BI753824 BU753921 AL547407

highest scoring ESTs for MAP3K8:

AA149109 AA151281 AA151340 AA151341 AA156603 AA156840 AA677028 AA768943 AI042009 AI147596

Unigene Cluster for MAP3K8:

Mitogen-activated protein kinase kinase kinase 8

Hs.432453 [show with all ESTs]

Unigene Representative Sequence: AB209539

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K8 (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10
SP1:							-		-		-				-		-
SP2:
SP3:							-		-		-		-		-		-
SP4:											-		-		-		-
SP5:											-				-		-

About this scheme

ECgene alternative splicing isoforms for MAP3K8

4 Ensembl transcripts including schematic representations:

ENST00000375322 ENST00000375328 ENST00000375321 ENST00000263056

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAP3K8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAP3K8

¹ / ² / ³

8 probe-sets matching MAP3K8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1891_at²^{, 3}	U95-A	1	1.00	1.00	0.86	0.92	D14497	0.80	1.00	0.91	1
34770_at²^{, 3}	U95-A	1	1.00	1.00	0.86	0.63	Z14138	0.80	1.00	0.91	1
76490_at*²^{, 3}	U95-D	1	1.00	1.00	0.41	1.41	AI684337	0.60	1.00	0.82	1
42838_f_at*²^{, 3}	U95-B	20	0.44	0.40	0.26	1.15	W42450	0.60	1.00	0.82	1
205027_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005204	0.60	1.00	0.82	1
235421_at*²^{, 3}	U133-B	1	1.00	1.00	--	--	AV713062	0.40	1.00	0.76	1
205027_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235421_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MAP3K8 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATCTTTCAT

SOURCE GeneReport for Unigene cluster: Hs.432453
Expression variation in blood from EXPOLDB for MAP3K8
UniProtKB/Swiss-Prot: M3K8_HUMAN, P41279
Tissue specificity: Expressed in several normal tissues and human tumor-derived cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAP3K8 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAP3K8¹	--	mitogen-activated protein kinase kinase kinase 8	91.51(n) 97.22(a)	487085 XM_544213.2 XP_544213.2
chimpanzee (Pan troglodytes)	MAP3K8¹	--	mitogen-activated protein kinase kinase kinase 8	99.14(n) 99.57(a)	450384 XM_001136851.1 XP_001136851.1
cow (Bos taurus)	MAP3K8¹	--	mitogen-activated protein kinase kinase kinase 8	88.79(n) 96.36(a)	535622 XM_615730.3 XP_615730.3
rat (Rattus norvegicus)	Map3k8¹	--	mitogen-activated protein kinase kinase kinase 8	87.65(n) 94(a)	116596 NM_053847.1 NP_446299.1
mouse (Mus musculus)	Map3k8^{1, 5}	18 (0.00 cM)⁵	mitogen-activated protein kinase kinase kinase 8^{1, 5}	87.79(n)¹ 93.36(a)¹	26410¹ NM_007746.2¹ NP_031772.1¹ AK140334⁵ AK149624⁵ (see all 12)

About this table Species with no ortholog for MAP3K8

ENSEMBL Gene Tree for MAP3K8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAP3K8 gene

MAP3K4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/260 NCBI SNPs in MAP3K8 are shown (see all 260 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 135)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3034^1,2	A,C,F,H,O	30789901(+)	`GACCCA/GTGAAT`	1	--	ut3¹		24	EA NA NS EU WA	1826
	rs619864^1,2	A,C,F,H,O	30790956(+)	`TCCCCT/CGGTAC`	1	--	ng3¹		17	NS NA EU EA WA	1470
	rs8176943^1,2	A,C,F,H	30761811(+)	`GCACGG/AACCTG`	1	--	ng5¹		12	NS EU EA WA	1162
	rs9338188^1,2	A,C,F,H	30761969(+)	`TCCTAG/CCTCTC`	1	--	ng5¹		7	NA EU EA WA	524
	rs8176948^1,2	C,F,H	30762799(+)	`ATTCGG/AGCCGC`	1	--	ng5¹		12	NS EU EA WA	1170
	rs8177037^1,2	C,F,H	30790663(+)	`TATGTG/AAGTAG`	1	--	ut3¹ ese³		9	NS EU EA WA NA	646
	rs7100157^1,2	C,F,H	30790911(+)	`TCTATT/GGCTCT`	1	--	ng3¹		15	NS EU EA WA NA	1316
	rs306587^1,2	A,C,F	30762914(-)	`CCCCCG/CACCCG`	1	--	ut5¹ trp³		3	NS MN	278
	rs8177039^1,2	C,F,H	30790730(+)	`TGTGGT/CTGGTC`	1	--	ut3¹		14	NS EU EA NA	1180
	rs8176952^1,2	C,F,H	30763032(+)	`CTGGCG/ATCCGC`	1	--	ut5¹ ese³		9	NS EU EA WA NA	648

About this table

HapMap Linkage Disequilibrium images for MAP3K8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 191195 disorders: 211980

3 Novoseek disease relationships for MAP3K8 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	3.08	4	18831712 (1), 2072910 (1), 18319612 (1)
tumors	0.02	1	7937886 (1)
inflammation	0.00	2	15699325 (1), 16039990 (1)

About this table

Human Genome Epidemiology Navigator: MAP3K8 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/67 PubMed articles for MAP3K8 gene (see all 67 ):

Structure and transforming potential of the human cot oncogene encoding a putative protein kinase. (PubMed id 2072910)^{1, 2, 3, 4} Miyoshi J.... Kakunaga T. (1991)
Expression cDNA cloning of a serine kinase transforming gene. (PubMed id 8479752)^{2, 3, 4} Chan A.M....Aaronson S.A. (1993)
ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. (PubMed id 15169888)^{1, 3, 4} Lang V....Ley S.C. (2004)
COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation. (PubMed id 10896655)^{1, 3, 4} Sanchez-Gongora E.... Alemany S. (2000)
The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation. (PubMed id 8226782)^{1, 3, 4} Aoki M.... Toyoshima K. (1993)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification and characterization of protein products of the cot oncogene with serine kinase activity. (PubMed id 1833717)^{3, 4} Aoki M.... Toyoshima K. (1991)
The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2. (PubMed id 11932422)^{1, 3} Eliopoulos A.G....Young L.S. (2002)
Proteomics analysis of immunoprecipitated proteins associated with the oncogenic kinase cot. (PubMed id 18319612)^{1, 3} Wu B. and Wilmouth R.C. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1326	HGNC: 6860	AceView: MAP3K8	Ensembl:ENSG00000107968	euGenes: HUgn1326
ECgene: MAP3K8	H-InvDB: MAP3K8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MAP3K8	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/map3k8/

Licensable Technologies for MAP3K8
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MAP3K8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAP3K8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAP3K8		Antibodies for MAP3K8
	Explore super-pooled esiRNAs		Proteins for MAP3K8
	Lentivirus-delivered shRNAs for MAP3K8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
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	Recombinant Proteins (MAP3K8)
	Antibodies (MAP3K8)
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Antibodies & Assays for MAP3K8 (Cot)

	Recombinant Proteins (MAP3K8)
	Antibodies (MAP3K8)

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Antibodies for MAP3K8

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MAP3K8 Gene at Home site.
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MAP3K8 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for MAP3K8

Summaries
for MAP3K8

Genomic Location
for MAP3K8

Proteins
for MAP3K8

Protein Domains/
Families
for MAP3K8

Gene Function
for MAP3K8

Pathways & Interactions
for MAP3K8

Drugs & Compounds
for MAP3K8

Transcripts
for MAP3K8

Expression
for MAP3K8

Orthologs
for MAP3K8

Paralogs
for MAP3K8

SNPs/Variants
for MAP3K8

Disorders & Mutations
for MAP3K8

Medical News
for MAP3K8

Publications
for MAP3K8

Search for MAP3K8

Genome Databases showing MAP3K8

Other Databases showing MAP3K8

Specialized Databases showing MAP3K8

Licensable Technologies
for MAP3K8

Services
for MAP3K8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAP3K8 (Gene Symbol)
C-COT
COT
EC 2.7.11.25
EST
ESTF
FLJ10486
OTTHUMP00000019392
OTTHUMP00000019393
TPL-2
TPL2
Tpl-2
c-COT
COT proto-oncogene serine/threonine-protein kinase
Cancer Osaka thyroid oncogene
Ewing sarcoma transformant
Tumor progression locus 2
cot (cancer Osaka thyroid) oncogene
mitogen-activated protein kinase kinase kinase 8
proto-oncogene serine/threoine protein kinase
tumor progression locus-2

MAP3K8 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor MAP3K8

Summariesfor MAP3K8

Genomic Locationfor MAP3K8

Proteinsfor MAP3K8

Protein Domains/Familiesfor MAP3K8

Gene Functionfor MAP3K8

Pathways & Interactionsfor MAP3K8

Drugs & Compoundsfor MAP3K8

Transcriptsfor MAP3K8

Expression for MAP3K8

Orthologsfor MAP3K8

Paralogsfor MAP3K8

SNPs/Variantsfor MAP3K8

Disorders & Mutationsfor MAP3K8

Medical Newsfor MAP3K8

Publicationsfor MAP3K8

Search for MAP3K8

Genome Databases showing MAP3K8

Other Databases showing MAP3K8

Specialized Databases showing MAP3K8

Licensable Technologiesfor MAP3K8

Servicesfor MAP3K8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAP3K8

Summaries
for MAP3K8

Genomic Location
for MAP3K8

Proteins
for MAP3K8

Protein Domains/
Families
for MAP3K8

Gene Function
for MAP3K8

Pathways & Interactions
for MAP3K8

Drugs & Compounds
for MAP3K8

Transcripts
for MAP3K8

Expression
for MAP3K8

Orthologs
for MAP3K8

Paralogs
for MAP3K8

SNPs/Variants
for MAP3K8

Disorders & Mutations
for MAP3K8

Medical News
for MAP3K8

Publications
for MAP3K8

Licensable Technologies
for MAP3K8

Services
for MAP3K8