Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAP3K7CL Gene

Aliases for MAP3K7CL Gene

  • MAP3K7 C-Terminal Like 2 3 5
  • C21orf7 3 4
  • TAK1L 3 4
  • Chromosome 21 Open Reading Frame 7 2
  • TGF-Beta Activated Kinase 3
  • TAK1-Like Protein 1 3
  • TAK1-Like Protein 2 3
  • TAK1-Like Protein 4 3
  • TAK1-Like Protein 4
  • HC21ORF7 3
  • TAKL-1 3
  • TAKL-2 3
  • TAKL-4 3
  • TAKL 3

External Ids for MAP3K7CL Gene

Previous HGNC Symbols for MAP3K7CL Gene

  • C21orf7

Previous GeneCards Identifiers for MAP3K7CL Gene

  • GC21P030450

Summaries for MAP3K7CL Gene

GeneCards Summary for MAP3K7CL Gene

MAP3K7CL (MAP3K7 C-Terminal Like) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway.

Gene Wiki entry for MAP3K7CL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K7CL Gene

Genomics for MAP3K7CL Gene

Regulatory Elements for MAP3K7CL Gene

Promoters for MAP3K7CL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAP3K7CL on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP3K7CL Gene

Chromosome:
21
Start:
29,077,471 bp from pter
End:
29,175,889 bp from pter
Size:
98,419 bases
Orientation:
Plus strand

Genomic View for MAP3K7CL Gene

Genes around MAP3K7CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K7CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K7CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K7CL Gene

Proteins for MAP3K7CL Gene

  • Protein details for MAP3K7CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57077-M3KCL_HUMAN
    Recommended name:
    MAP3K7 C-terminal-like protein
    Protein Accession:
    P57077
    Secondary Accessions:
    • D3DSE0
    • Q8TCL9

    Protein attributes for MAP3K7CL Gene

    Size:
    242 amino acids
    Molecular mass:
    27248 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB90434.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K7CL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K7CL Gene

Proteomics data for MAP3K7CL Gene at MOPED

Post-translational modifications for MAP3K7CL Gene

No Post-translational modifications

Antibody Products

  • Cloud-Clone Corp. Antibodies for MAP3K7CL

No data available for DME Specific Peptides for MAP3K7CL Gene

Domains & Families for MAP3K7CL Gene

Protein Domains for MAP3K7CL Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P57077

UniProtKB/Swiss-Prot:

M3KCL_HUMAN :
  • Contains a C-terminal domain similar to that of the C-terminal section of MAP3K7.
Domain:
  • Contains a C-terminal domain similar to that of the C-terminal section of MAP3K7.
genes like me logo Genes that share domains with MAP3K7CL: view

No data available for Gene Families for MAP3K7CL Gene

Function for MAP3K7CL Gene

genes like me logo Genes that share phenotypes with MAP3K7CL: view

Animal Model Products

CRISPR Products

miRNA for MAP3K7CL Gene

miRTarBase miRNAs that target MAP3K7CL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP3K7CL Gene

Localization for MAP3K7CL Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MAP3K7CL Gene

Pathways & Interactions for MAP3K7CL Gene

genes like me logo Genes that share pathways with MAP3K7CL: view

Pathways by source for MAP3K7CL Gene

1 BioSystems pathway for MAP3K7CL Gene

Gene Ontology (GO) - Biological Process for MAP3K7CL Gene

None

No data available for SIGNOR curated interactions for MAP3K7CL Gene

Drugs & Compounds for MAP3K7CL Gene

No Compound Related Data Available

Transcripts for MAP3K7CL Gene

Unigene Clusters for MAP3K7CL Gene

MAP3K7 C-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K7CL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - - -
SP8: - -
SP9:

Relevant External Links for MAP3K7CL Gene

GeneLoc Exon Structure for
MAP3K7CL
ECgene alternative splicing isoforms for
MAP3K7CL

Expression for MAP3K7CL Gene

mRNA expression in normal human tissues for MAP3K7CL Gene

mRNA differential expression in normal tissues according to GTEx for MAP3K7CL Gene

This gene is overexpressed in Artery - Coronary (x4.9), Muscle - Skeletal (x4.5), Artery - Tibial (x4.3), and Artery - Aorta (x4.0).

Protein differential expression in normal tissues from HIPED for MAP3K7CL Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP3K7CL Gene



SOURCE GeneReport for Unigene cluster for MAP3K7CL Gene Hs.222802

mRNA Expression by UniProt/SwissProt for MAP3K7CL Gene

P57077-M3KCL_HUMAN
Tissue specificity: Detected in lung and peripheral blood leukocytes. Expressed predominantly in peripheral blood leukocytes and ubiquitously in adult and fetal tissues. Also expressed strongly in breast carcinoma GI-101, colon adenocarcinoma GI-112, and prostatic adenocarcinoma PC3.
genes like me logo Genes that share expression patterns with MAP3K7CL: view

Protein tissue co-expression partners for MAP3K7CL Gene

Primer Products

In Situ Assay Products

Orthologs for MAP3K7CL Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP3K7CL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C21H21orf7 35
  • 99.59 (n)
  • 99.17 (a)
MAP3K7CL 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP3K7CL 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map3k7cl 36
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H21ORF7 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP3K7CL 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP3K7CL 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii map3k7cl 36
  • 40 (a)
OneToOne
Species with no ortholog for MAP3K7CL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K7CL Gene

ENSEMBL:
Gene Tree for MAP3K7CL (if available)
TreeFam:
Gene Tree for MAP3K7CL (if available)

Paralogs for MAP3K7CL Gene

(2) SIMAP similar genes for MAP3K7CL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MAP3K7CL: view

No data available for Paralogs for MAP3K7CL Gene

Variants for MAP3K7CL Gene

Sequence variations from dbSNP and Humsavar for MAP3K7CL Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs3746843 - 29,092,545(+) AGTCT(A/G)TTACT reference, missense, utr-variant-5-prime
rs14498 -- 29,175,697(-) ACAAT(A/C)GTTAC utr-variant-3-prime
rs1054718 -- 29,095,356(+) GGAGC(C/G)TTTTG intron-variant
rs1467749 -- 29,128,735(+) ATTGT(C/G)TGCGT intron-variant, upstream-variant-2KB
rs1467750 -- 29,129,037(+) CCTTT(A/T)ACTTG intron-variant, upstream-variant-2KB

Variation tolerance for MAP3K7CL Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K7CL Gene

HapMap Linkage Disequilibrium report
MAP3K7CL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAP3K7CL Gene

Disorders for MAP3K7CL Gene

Relevant External Links for MAP3K7CL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K7CL

No disorders were found for MAP3K7CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K7CL Gene

Publications for MAP3K7CL Gene

  1. Cloning and characterization of a novel human TGF-beta activated kinase-like gene. (PMID: 15168726) Li J. … Mao Y. (Biochem. Genet. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Genome-wide association scan of dental caries in the permanent dentition. (PMID: 23259602) Wang X. … Marazita M.L. (BMC Oral Health 2012) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for MAP3K7CL Gene

Sources for MAP3K7CL Gene

Back to Top

Content