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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K7 Gene

protein-coding   GIFtS: 71
GCID: GC06M091282

Mitogen-Activated Protein Kinase Kinase Kinase 7


(Previous symbol: TAK1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 71 2     MEKK72
TAK11 2 3 5     TGF1a2
Transforming Growth Factor-Beta-Activated Kinase 12 3     TGF-Beta Activated Kinase 12
TGF-Beta-Activated Kinase 12 3     EC 2.7.118
EC 2.7.11.253 8     

External Ids:    HGNC: 68591   Entrez Gene: 68852   Ensembl: ENSG000001353417   OMIM: 6026145   UniProtKB: O433183   

Export aliases for MAP3K7 gene to outside databases

Previous GC identifers: GC06M091171 GC06M091220 GC06M088444


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP3K7 Gene:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates
the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell
functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase
complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear
factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response
to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been
reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP3K7 Gene: 
MAP3K7 (mitogen-activated protein kinase kinase kinase 7) is a protein-coding gene. Diseases associated with MAP3K7 include hypohidrotic ectodermal dysplasia, and ectodermal dysplasia, and among its related super-pathways are B cell receptor signaling pathway and Wnt signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: M3K7_HUMAN, O43318
Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment.
Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth
factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor
receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as
an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade
through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3,
MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and
I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator
protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in
response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role
in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity

Gene Wiki entry for MAP3K7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007299.13  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K7 gene promoter:
         STAT3   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP3K7 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP3K7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q15

MAP3K7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M091282:  view genomic region     (about GC identifiers)

Start:
91,223,292 bp from pter      End:
91,296,907 bp from pter
Size:
73,616 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M3K7_HUMAN, O43318 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 7  
Size: 606 amino acids; 67196 Da
Cofactor: Magnesium
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with
TAB1/MAP3K7IP1, TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3. Identified in the TRIKA2 complex composed of MAP3K7/TAK1,
TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L and PPM1B/PP2CB. Interaction with PP2A and PPP6C leads to
its repressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and
TAOK2; interaction with TAOK2 interferes with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B
activation. Interacts with WDR34 (via WD domains). Interacts with CYLD and RBCK1. Interacts with TGFBR1; induces
MAP3K7/TAK1 activation by TRAF6. Interacts with MAPK8IP1 and SMAD6 (By similarity). Interacts with isoform 1 of
VRK2. Interacts with DAB2; the interaction is induced by TGF-beta stimulation and may mediate TGF-beta stimulated
JNK activation. Interacts with TRIM5
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Although the
majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is
also localized at the cell membrane
3 PDB 3D structures from and Proteopedia for MAP3K7:
2EVA (3D)        2YIY (3D)        4GS6 (3D)    
Secondary accessions: B2RE27 E1P523 O43317 O43319 Q5TDN2 Q5TDN3 Q5TDT7 Q9NTR3 Q9NZ70
Alternative splicing: 4 isoforms:  O43318-1   O43318-2   O43318-3   O43318-4   

Explore the universe of human proteins at neXtProt for MAP3K7: NX_O43318

Explore proteomics data for MAP3K7 at MOPED 

Post-translational modifications:

  • UniProtKB: Association with TAB1/MAP3K7IP1 promotes autophosphorylation at Ser-192 and subsequent activation. Association
    with TAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes
    autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Ser-192 by PPM1B/PP2CB and at
    Thr-187 by PP2A and PPP6C leads to inactivation
  • UniProtKB: Ubiquitinated, leading to proteasomal degradation (By similarity). Requires 'Lys-63'-linked polyubiquitination for
    autophosphorylation and subsequent activation. 'Lys-63'-linked ubiquitination does not lead to proteasomal
    degradation. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains.
    Deubiquitinated by Y.enterocolitica YopP
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43318

  • 4/6 DME Specific Peptides for MAP3K7 (O43318) (see all 6)
     VGRGAFG  LKICDFG  YSEKCDV  NHPNIVKL 

    MAP3K7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP3K7 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_003179.1  NP_663304.1  NP_663305.1  NP_663306.1  

    ENSEMBL proteins: 
     ENSP00000358331   ENSP00000358333   ENSP00000358338   ENSP00000358335   ENSP00000358326  
    Reactome Protein details: O43318
    Human Recombinant Protein Products for MAP3K7: 
    EMD Millipore Purified and/or Recombinant MAP3K7 Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for MAP3K7
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    GenScript Custom Purified and Recombinant Proteins Services for MAP3K7
    Novus Biologicals MAP3K7 Proteins
    Novus Biologicals MAP3K7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP3K7 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005671Ada2/Gcn5/Ada3 transcription activator complex IDA18838386
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0008385colocalizes with IkappaB kinase complex IPI10094049
    GO:0010008endosome membrane TAS--

    MAP3K7 for ontologies           About GeneDecksing



    MAP3K7 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP3K7
    R&D Systems Antibodies for MAP3K7 (TAK1)
    Cell Signaling Technology (CST) Antibodies for MAP3K7  (TAK1)
    OriGene Antibodies for MAP3K7
    OriGene Custom Antibody Services for MAP3K7
    GenScript Custom Superior Antibodies Services for MAP3K7
    Novus Biologicals MAP3K7 Antibodies
    Abcam antibodies for MAP3K7
    Cloud-Clone Corp. Antibodies for MAP3K7 
    ThermoFisher Antibody for MAP3K7
    LSBio Antibodies in human, mouse, rat for MAP3K7 

    Assay Products for MAP3K7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAP3K7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP3K7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP3K7 
    Cloud-Clone Corp. CLIAs for MAP3K7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 7 
    TAK1 subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom
     IPR017421 MAPKKK7

    Graphical View of Domain Structure for InterPro Entry O43318

    ProtoNet protein and cluster: O43318

    UniProtKB/Swiss-Prot: M3K7_HUMAN, O43318
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    MAP3K7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K7_HUMAN, O43318
    Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment.
    Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth
    factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor
    receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as
    an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade
    through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3,
    MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and
    I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator
    protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in
    response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role
    in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by proinflammatory cytokines and in response to physical and chemical stresses,
    including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by
    'Lys-63'-linked polyubiquitination and by autophosphorylation. Association with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2
    promotes activation through autophosphorylation, whereas PPM1B/PP2CB, PP2A and PPP6C dephosphorylation leads to
    inactivation

         Genatlas biochemistry entry for MAP3K7:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 7,widely expressed,activated by MAP4K4 (see symbol) in
    JNK signaling pathway,involved in the BMP signaling through binding with API3 (XIAP)3,also associating with TRAF6
    during IL-1 signaling and activating NFKB

         Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity IDA10094049
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004708MAP kinase kinase activity IEA--
    GO:0004709MAP kinase kinase kinase activity IDA11460167
         
    MAP3K7 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for MAP3K7:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Gemcitabine induced cell-death  Increased cell number in G1, s  Upregulation of Wnt/beta-caten 

         15/17 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Map3k7) (see all 17):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  limbs/digits/tail  liver/biliary system  mortality/aging  muscle 

    MAP3K7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAP3K7: Map3k7tm1.1Mds Map3k7tm1.1Aki

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP3K7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP3K7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP3K7 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP3K7:
    hsa-mir-10a (MIRT005509)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K7
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K7:
    hsa-miR-448 hsa-miR-10b hsa-miR-143 hsa-miR-3614-3p hsa-miR-377 hsa-miR-589* hsa-miR-10a
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAP3K7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP3K7
    Sirion Biotech Customized adenovirus for overexpression of MAP3K7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAP3K7 (see all 25)
    OriGene ORF clones in mouse, rat for MAP3K7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAP3K7 (NM_145331)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K7
    Sirion Biotech Customized lentivirus for stable overexpression of MAP3K7 
                         Customized lentivirus expression plasmids for stable overexpression of MAP3K7 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAP3K7 About   (see all 77)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1B cell receptor signaling pathway
    BCR signaling pathway0.42
    TCR Signaling Pathway0.35
    T cell receptor signaling pathway0.38
    2Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    3Toll Comparative Pathway
    Toll Comparative Pathway0.61
    Immune response IL-1 signaling pathway0.41
    TLR-TRIF Pathway0.61
    IL-1 Pathway0.39
    Immune response MIF in innate immunity response0.46
    4BAFF in B-Cell Signaling
    BAFF in B-Cell Signaling0.92
    RANK Signaling in Osteoclasts0.45
    APRIL Pathway0.92
    RANKL/RANK Signaling Pathway0.31
    5Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/10 EMD Millipore Pathways for MAP3K7 (see all 10)
        Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Immune response MIF in innate immunity response
    Development TGF-beta receptor signaling
    Immune response IL-1 signaling pathway
    Translation Regulation activity of EIF4F

    5 R&D Systems Pathways for MAP3K7
        NOD-like Receptor Signaling Pathways
    Wnt Signaling Pathway
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    TGF-beta Signaling Pathways

    5/31 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K7 (see all 31)
        MAPK Signaling
    Toll-Like Receptors Pathway
    TRAF Pathway
    Molecular Mechanisms of Cancer
    JNK Pathway

    3 Cell Signaling Technology (CST) Pathways for MAP3K7
        MAP Kinase Signaling
    TGF-beta/Smad Signaling
    NF-kappaB Signaling

    5/17 GeneGo (Thomson Reuters) Pathways for MAP3K7 (see all 17)
        Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Transcription PPAR Pathway
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Development TGF-beta receptor signaling

    5/27 BioSystems Pathways for MAP3K7 (see all 27)
        MAPK signaling pathway
    EBV LMP1 signaling
    NLR proteins
    DNA damage response (only ATM dependent)
    Insulin Signaling

    5/40        Reactome Pathways for MAP3K7 (see all 40)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    FCERI mediated NF-kB activation
    IRAK2 mediated activation of TAK1 complex
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex

    1 PharmGKB Pathway for MAP3K7
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    5/15         Kegg Pathways  (Kegg details for MAP3K7) (see all 15):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Wnt signaling pathway
    Osteoclast differentiation
    Adherens junction


    MAP3K7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/257 Interacting proteins for MAP3K7 (O433181, 2, 3 ENSP000003583354) via UniProtKB, MINT, STRING, and/or I2D (see all 257)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAB2Q9NYJ81, 2, 3, ENSP000002863324EBI-358684,EBI-358708 MINT-49214 MINT-8303915 MINT-48035 MINT-6797216 MINT-2842686 MINT-49239 MINT-8303890 I2D: score=8 STRING: ENSP00000286332
    TAB1Q157502, 3, ENSP000002161604MINT-6797194 MINT-49229 MINT-49178 MINT-6797216 MINT-2842623 MINT-48034 I2D: score=6 STRING: ENSP00000216160
    TAB3Q8N5C82, 3, ENSP000002884224MINT-49237 MINT-8303905 MINT-8303937 MINT-48036 I2D: score=4 STRING: ENSP00000288422
    IKBKBO149202, 3, ENSP000003391514MINT-4652778 I2D: score=6 STRING: ENSP00000339151
    IKBKGQ9Y6K92, 3, ENSP000003586224MINT-4652797 I2D: score=5 STRING: ENSP00000358622
    About this table

    Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000186activation of MAPKK activity IDA8663074
    GO:0000187activation of MAPK activity TAS--
    GO:0001525angiogenesis IEA--
    GO:0001841neural tube formation IEA--

    MAP3K7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP3K7 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAP3K7:
    Small Molecule - inhibitor
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    Browse Tocris compounds for MAP3K7 (M3K7)

    3 HMDB Compounds for MAP3K7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    10/13 Novoseek inferred chemical compound relationships for MAP3K7 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-1 97.8 120 10702308 (5), 16845370 (5), 19578758 (5), 17052891 (4) (see all 45)
    tab-2 97.3 104 17158449 (8), 19955178 (7), 17986383 (5), 16251197 (4) (see all 34)
    threonine 46.5 6 18299321 (1), 10838074 (1), 17079228 (1), 15773898 (1)
    sb 203580 42.1 3 12670941 (1), 15590691 (1)
    serine 34.1 8 14670075 (1), 18818394 (1), 10702308 (1), 18299321 (1) (see all 6)
    anisomycin 29.3 2 11259586 (1)
    rantes 3.49 5 12243350 (4)
    lysine 2.83 5 15327770 (1), 19843958 (1), 17418100 (1), 17496917 (1)
    thymidine 0 1 15492278 (1)
    oxygen 0 1 19421137 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP3K7 / M3K7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP3K7 gene (4 alternative transcripts): 
    NM_003188.3  NM_145331.2  NM_145332.2  NM_145333.2  

    Unigene Cluster for MAP3K7:

    Mitogen-activated protein kinase kinase kinase 7
    Hs.594838  [show with all ESTs]
    Unigene Representative Sequence: NM_145331
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369325 ENST00000369327 ENST00000369332(uc003pob.1 uc003poc.1)
    ENST00000369329(uc003pnz.1 uc003poa.1) ENST00000479630(uc003pny.1)
    ENST00000369320
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB009356.1 AB009357.1 AB009358.2 AF218074.1 AK055901.1 AK299268.1 AK315774.1 BC017715.2 
    BT019654.1 BT019655.1 BX648277.1 

    19 DOTS entries:

    DT.91761210  DT.440705  DT.100789441  DT.100789443  DT.91761184  DT.407247  DT.95192753  DT.121317912 
    DT.92034339  DT.95192756  DT.121317902  DT.121317926  DT.121317938  DT.91741806  DT.91761185  DT.91761192 
    DT.100726302  DT.121317906  DT.95141563 

    24/236 AceView cDNA sequences (see all 236):

    NM_145333 BF218984 AB009358 BF110332 AW137182 BQ958174 AA044137 NM_145332 
    AI183761 AA578855 AI370889 AF218074 AA314749 T25731 CA950641 CD370793 
    AW674292 AI978873 AA306104 AI473095 BX364931 BU150117 AB009356 AA460969 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K7 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ·
    SP1:                                -                             -                                                                                             
    SP2:                                -                             -                                                     -                                       
    SP3:                                                                                                                    -                                       
    SP4:                                -                                                                                                                           
    SP5:                                -                                                                                                                           

    ExUns: 19c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for MAP3K7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K7 expression in normal human tissues (normalized intensities)      MAP3K7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCATTGTGT
    MAP3K7 Expression
    About this image


    MAP3K7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             mandibular prominence tissue e12.5   
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             mandibular prominence tissue e12.5   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             brain/hindbrain   
     
     Inner Cell Mass (Early Embryonic Tissues)
             201B7

    See MAP3K7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K7

    SOURCE GeneReport for Unigene cluster: Hs.594838

    UniProtKB/Swiss-Prot: M3K7_HUMAN, O43318
    Tissue specificity: Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells.
    Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate.
    Isoform 1D is the less abundant form

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP3K7 (see all 8): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Antibacterial Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAP3K7 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k71 , 5 mitogen-activated protein kinase kinase kinase 71, 5 91.71(n)1
    99.31(a)1
      4 (13.91 cM)5
    264091  NM_172688.31  NP_766276.11 
     319640975 
    chicken
    (Gallus gallus)
    Aves MAP3K71 mitogen-activated protein kinase kinase kinase 7 85.51(n)
    92.76(a)
      421808  XM_419832.3  XP_419832.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K76
    Uncharacterized protein
    89(a)
    1 ↔ 1
    1(174180273-174234955)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.2742 Xenopus laevis TGF-beta-activated kinase TAK1 mRNA, more 81.32(n)    U92030.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.171312 Transcribed sequence with weak similarity to protein more 75.76(n)    CF265381.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tak11 , 3 JNK cascade protein kinase3
    TGF-beta activated kinase 11
    54(a)
    (best of 3)3
    48.49(n)1
    42.64(a)1
      19D23
    396591  NM_079356.21  NP_524080.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mom-43
    CELE_Y105C5A.241
    tyrosine-protein kinase3
    Protein Y105C5A.241
    32(a)3
    42.83(n)1
    31.98(a)1
      I(9904036-9908653)3
    1908821  NM_070487.21  NP_502888.21 


    ENSEMBL Gene Tree for MAP3K7 (if available)
    TreeFam Gene Tree for MAP3K7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP3K7 gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  KSR12  MOS2  
    BRAF2  MAP3K92  MAP3K102  ARAF2  TNNI3K2  ZAK2  MAP3K132  ILK2  
    1 SIMAP similar gene for MAP3K7 using alignment to 1 protein entry:     M3K7_HUMAN:
    DKFZp586F0420

    MAP3K7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1345 SNPs in MAP3K7 are shown (see all 1345)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835875821,2
    --91201267(+) GTGCAA/GTTTAT 4 -- ds50010--------
    rs12316461,2
    C,F,O,H--91201469(+) TTAGCG/AATGTA 4 -- ds500117Minor allele frequency- A:0.39MN NA NS EA WA CSA 1114
    rs1379482611,2
    --91201478(+) TATGAC/TGTGTT 4 -- ds50010--------
    rs729138821,2
    C--91201586(+) CAGCCG/TCTTAA 4 -- ds50010--------
    rs1165676561,2
    F--91201592(+) CTTAAA/GAACCA 4 -- ds50011Minor allele frequency- G:0.05WA 118
    rs1866393031,2
    --91201606(+) TTATCA/GTACAA 4 -- ds50010--------
    rs1471679931,2
    C--91201656(+) AACACA/GGTGCT 4 -- ds50010--------
    rs1387084241,2
    --91201739(+) AATCTA/GAATTT 4 -- ut310--------
    rs1919405571,2
    --91201754(+) AAAAAC/TAAAAA 4 -- ut310--------
    rs21807361,2
    C,F,O,A,H--91201867(-) CAAATG/AGTAGT 4 -- ut31 ese312Minor allele frequency- A:0.02NA NS EA 882

    HapMap Linkage Disequilibrium report for MAP3K7 (91223292 - 91296907 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MAP3K7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1333350CNV Deletion17803354
    esv2449643CNV Deletion19546169
    esv2732413CNV Deletion23290073
    esv992475CNV Deletion20482838
    esv3668CNV Deletion18987735
    esv1987764CNV Deletion18987734
    esv5848CNV Loss19470904
    nsv523939CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): MAP3K7
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    Prostate Cancer
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602614    OMIM disorders: --

    20/33 diseases for MAP3K7 (see all 33):    About MalaCards
    hypohidrotic ectodermal dysplasia    ectodermal dysplasia    toxoplasmosis    kawasaki disease
    vaccinia    measles    leishmaniasis    kaposi's sarcoma
    narcolepsy    celiac disease    graves' disease    rheumatoid arthritis
    crohn's disease    arthritis    chronic lymphocytic leukemia    sarcoma
    pneumonia    ischemia    melanoma    prostate cancer


    MAP3K7 for disorders           About GeneDecksing

    10/14 Novoseek inferred disease relationships for MAP3K7 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 51.4 34 19955178 (2), 15647289 (1), 17854800 (1), 19026643 (1) (see all 20)
    tumors 35.8 35 19419968 (3), 19955178 (2), 15647289 (1), 17854800 (1) (see all 18)
    inflammation 22.8 2 16459052 (1), 11129660 (1)
    adenocarcinoma lung 8.3 1 17325661 (1)
    cancer 3.73 2 17172402 (1), 17325661 (1)
    breast carcinoma 0 1 16000313 (1)
    ischemia 0 1 17085580 (1)
    shock 0 3 17202147 (1), 18950863 (1)
    cancer lung 0 1 9466656 (1)
    breast cancer 0 5 18316610 (2), 19049961 (1)

    Genetic Association Database (GAD): MAP3K7
    Human Genome Epidemiology (HuGE) Navigator: MAP3K7 (9 documents)

    Export disorders for MAP3K7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K7 gene, integrated from 9 sources (see all 376):
    (articles sorted by number of sources associating them with MAP3K7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. (PubMed id 16893890)1, 2, 9 Huangfu W.C.... Ninomiya-Tsuji J. (2006)
    2. Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway. (PubMed id 17079228)1, 2, 9 Kajino T....Ninomiya-Tsuji J. (2006)
    3. Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1. (PubMed id 10838074)1, 2, 9 Sakurai H.... Sugita T. (2000)
    4. Direct activation of protein kinases by unanchored po lyubiquitin chains. (PubMed id 19675569)1, 2, 9 Xia Z.P....Chen Z.J. (2009)
    5. TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. (PubMed id 10702308)1, 2, 9 Kishimoto K....Ninomiya-Tsuji J. (2000)
    6. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. (PubMed id 18758450)1, 2, 9 Sorrentino A.... Landstrom M. (2008)
    7. Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. (PubMed id 12242293)1, 2, 9 Jiang Z....Li X. (2002)
    8. TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. (PubMed id 9079627)1, 2, 9 Shirakabe K....Nishida E. (1997)
    9. Structural basis for the interaction of TAK1 kinase with its activating protein TAB1. (PubMed id 16289117)1, 2, 9 Brown K....Cheetham G.M.T. (2005)
    10. TAB3, a new binding partner of the protein kinase TAK1. (PubMed id 14670075)1, 2, 9 Cheung P.C.... Cohen P. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6885 HGNC: 6859 AceView: MAP3K7 Ensembl:ENSG00000135341 euGenes: HUgn6885
    ECgene: MAP3K7 Kegg: 6885 H-InvDB: MAP3K7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP3K7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP3K7 gene:
    Search GeneIP for patents involving MAP3K7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     Proteins for MAP3K7
     Antibodies for MAP3K7
     ELISAs for MAP3K7
     CLIAs for MAP3K7
     Search LifeMap BioReagents cell lines for MAP3K7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K7
     SwitchGear 3'UTR luciferase reporter plasmids for MAP3K7
     SwitchGear Promoter luciferase reporter plasmids for MAP3K7
     ThermoFisher Antibody for MAP3K7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K7
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP3K7
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP3K7
    Customized:
     lentivirus for stable overexpression of MAP3K7
     lentivirus expression plasmids for stable overexpression of MAP3K7
     adenovirus for overexpression of MAP3K7
     LSBio Antibodies in human, mouse, rat for MAP3K7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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