MAP3K7 Gene
protein-coding GIFtS: 70
GCID: GC06M091282
|
|
mitogen-activated protein kinase kinase kinase 7
(Previous symbol: TAK1)
| |
Aliases
for MAP3K7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitogen-Activated Protein Kinase Kinase Kinase 71 2 | | EC 2.7.11.253 8 | | TAK11 2 3 5 | | TGF1a2 | | MEKK71 2 | | TGF-Beta Activated Kinase 12 | | Transforming Growth Factor-Beta-Activated Kinase 12 3 | | EC 2.7.118 | | TGF-Beta-Activated Kinase 12 3 | | |
Export aliases for MAP3K7 gene to outside databasesPrevious GC identifers: GC06M091171 GC06M091220 GC06M088444 |
Summaries
for MAP3K7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAP3K7:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates thesignaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functionsincluding transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex includingTRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Thiskinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.Four alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: M3K7_HUMAN, O43318Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaltransduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB),TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cellreceptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of theMKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation andactivation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks inturn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNKpathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated byIKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. Inosmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. PromotesTRIM5 capsid-specific restriction activity
Gene Wiki entry for MAP3K7
|
Genomic Views
for MAP3K7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP3K7 gene promoter:
STAT3 Sox9
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP3K7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q15 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q15MAP3K7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M091282: view genomic region
(about GC identifiers)
Start:
|
91,223,292 bp from pter |
End:
|
91,296,907 bp from pter |
Size:
|
73,616 bases |
Orientation:
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minus strand |
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Proteins
for MAP3K7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: M3K7_HUMAN, O43318 (See
protein sequence)Recommended Name: Mitogen-activated protein kinase kinase kinase 7 Size: 606 amino acids; 67196 Da
Cofactor: Magnesium
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts withTAB1/MAP3K7IP1, TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3. Identified in the TRIKA2 complex composed of MAP3K7/TAK1,TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L and PPM1B/PP2CB. Interaction with PP2A and PPP6C leads to itsrepressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and TAOK2;interaction with TAOK2 interferes with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation. Interactswith WDR34 (via WD domains). Interacts with CYLD and RBCK1. Interacts with TGFBR1; induces MAP3K7/TAK1 activation byTRAF6. Interacts with MAPK8IP1 and SMAD6 (By similarity). Interacts with isoform 1 of VRK2. Interacts with DAB2; theinteraction is induced by TGF-beta stimulation and may mediate TGF-beta stimulated JNK activation. Interacts withTRIM5
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Although themajority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is alsolocalized at the cell membrane
3 PDB 3D structures from  and Proteopedia  for MAP3K7:2EVA (3D)
2YIY (3D)
4GS6 (3D)
Secondary accessions: B2RE27 E1P523 O43317 O43319 Q5TDN2 Q5TDN3 Q5TDT7 Q9NTR3 Q9NZ70Alternative splicing: 4 isoforms: O43318-1 O43318-2 O43318-3 O43318-4 Explore the universe of human proteins at neXtProt for MAP3K7: NX_O43318
Post-translational modifications:
Association with TAB1/MAP3K7IP1 promotes autophosphorylation at Ser-192 and subsequent activation. Association withTAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation andsubsequent activation of MAP3K7. Dephosphorylation at Ser-192 by PPM1B/PP2CB and at Thr-187 by PP2A and PPP6C leads toinactivation1
Ubiquitinated, leading to proteasomal degradation (By similarity). Requires 'Lys-63'-linked polyubiquitination forautophosphorylation and subsequent activation. 'Lys-63'-linked ubiquitination does not lead to proteasomaldegradation. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains.Deubiquitinated by Y.enterocolitica YopP1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43318
4/6 DME Specific Peptides for MAP3K7 (O43318) (see all 6)
MAP3K7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_003179.1 NP_663304.1 NP_663305.1 NP_663306.1
ENSEMBL proteins: ENSP00000358338 ENSP00000358335 ENSP00000358331 ENSP00000358333 ENSP00000358326 Reactome Protein details: O43318
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
MAP3K7 for ontologies About GeneDecksing
MAP3K7 Antibody Products:
Assay Products for MAP3K7: |
Protein
Domains /
Families
for MAP3K7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP3K7 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O43318ProtoNet protein and cluster: O43318 UniProtKB/Swiss-Prot: M3K7_HUMAN, O43318Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinasesubfamilySimilarity: Contains 1 protein kinase domain |
Function
for MAP3K7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: M3K7_HUMAN, O43318Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway.Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaltransduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB),TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cellreceptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of theMKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation andactivation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks inturn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNKpathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated byIKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. Inosmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. PromotesTRIM5 capsid-specific restriction activityCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by proinflammatory cytokines and in response to physical and chemical stresses, includingosmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linkedpolyubiquitination and by autophosphorylation. Association with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2 promotes activationthrough autophosphorylation, whereas PPM1B/PP2CB, PP2A and PPP6C dephosphorylation leads to inactivation Genatlas biochemistry entry for MAP3K7:mitogen activated protein (MAP/ERK) kinase kinase kinase 7,widely expressed,activated by MAP4K4 (see symbol) in JNKsignaling pathway,involved in the BMP signaling through binding with API3 (XIAP)3,also associating with TRAF6 duringIL-1 signaling and activating NFKB
Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K7 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MAP3K7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K7 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
MAP3K7 for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for MAP3K7:
Animal Models:
Mouse knock-outs for MAP3K7: Map3k7tm1.1Mds Map3k7tm1.1Aki
15/17 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Map3k7) (see all 17):
MAP3K7 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAP3K7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/70 super-pathways (see all 70) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | Toll Comparative Pathway | | | 3 | Wnt Signaling Pathway | | | 4 | Mucin expression in CF via IL-6, IL-17 signaling pathways | | | 5 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 EMD Millipore Pathways for MAP3K7 (see all 10)
3  R&D Systems Pathways for MAP3K7
5/31 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K7 (see all 31)
3 
Cell Signaling Technology (CST) Pathways for MAP3K7
5/17  GeneGo (Thomson Reuters) Pathways for MAP3K7 (see all 17)
5/27  BioSystems Pathways for MAP3K7 (see all 27)
5/41 
Reactome Pathways for MAP3K7 (see all 41)
1  PharmGKB Pathway for MAP3K7
5/11 
Kegg Pathways (Kegg details for MAP3K7) (see all 11):
MAP3K7 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/240 Interacting proteins for MAP3K7 (O433181, 2, 3 ENSP000003583354) via UniProtKB, MINT, STRING, and/or I2D (see all 240)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TAB2 | Q9NYJ81, 2, 3, ENSP000002863324 | EBI-358684,EBI-358708 MINT-49214 MINT-8303915 MINT-48035 MINT-6797216 MINT-2842686 MINT-49239 MINT-8303890 I2D:
score=8 STRING: ENSP00000286332 | | TAB1 | Q157502, 3, ENSP000002161604 | MINT-6797194 MINT-49229 MINT-49178 MINT-6797216 MINT-2842623 MINT-48034 I2D:
score=6 STRING: ENSP00000216160 | | TAB3 | Q8N5C82, 3, ENSP000002884224 | MINT-49237 MINT-8303905 MINT-8303937 MINT-48036 I2D:
score=4 STRING: ENSP00000288422 | | IKBKB | O149202, 3, ENSP000003391514 | MINT-4652778 I2D:
score=6 STRING: ENSP00000339151 | | IKBKG | Q9Y6K92, 3, ENSP000003586224 | MINT-4652797 I2D:
score=5 STRING: ENSP00000358622 |
About this table
Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table
MAP3K7 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAP3K7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MAP3K7 for compounds About GeneDecksing
 Compounds for MAP3K7 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| (5Z)-7-Oxozeaenol | Potent and selective TAK1 MAPKKK inhibitor | [66018-38-0] |
3 HMDB Compounds for MAP3K7 About this table
10/13 Novoseek chemical compound relationships for MAP3K7 gene (see all 13) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tab-1 |
97.8 |
120 |
10702308 (5), 16845370 (5), 19578758 (5), 17052891 (4) (see all 45) |
| tab-2 |
97.3 |
104 |
17158449 (8), 19955178 (7), 17986383 (5), 16251197 (4) (see all 34) |
| threonine |
46.5 |
6 |
18299321 (1), 10838074 (1), 17079228 (1), 15773898 (1) |
| sb 203580 |
42.1 |
3 |
12670941 (1), 15590691 (1) |
| serine |
34.1 |
8 |
14670075 (1), 18818394 (1), 10702308 (1), 18299321 (1) (see all 6) |
| anisomycin |
29.3 |
2 |
11259586 (1) |
| rantes |
3.49 |
5 |
12243350 (4) |
| lysine |
2.83 |
5 |
15327770 (1), 19843958 (1), 17418100 (1), 17496917 (1) |
| thymidine |
0 |
1 |
15492278 (1) |
| oxygen |
0 |
1 |
19421137 (1) |
Search CenterWatch for drugs/clinical trials and news about MAP3K7 / M3K7
|
Transcripts
for MAP3K7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAP3K7 gene (4 alternative transcripts): NM_003188.3 NM_145331.2 NM_145332.2 NM_145333.2 Unigene Cluster for MAP3K7: Mitogen-activated protein kinase kinase kinase 7 Hs.594838 [show with all ESTs]Unigene Representative Sequence: NM_1453316 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369332(uc003pob.1 uc003poc.1) ENST00000369329(uc003pnz.1 uc003poa.1)
ENST00000369325 ENST00000369327 ENST00000479630(uc003pny.1) ENST00000369320
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K7 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K7 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): MAP3K7 (NM_145331) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP3K7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K7 |
Additional cDNA sequence: AB009356.1 AB009357.1 AB009358.2 AF218074.1 AK055901.1 AK299268.1 AK315774.1 BC017715.2 BT019654.1 BT019655.1 BX648277.1 19 DOTS entries: DT.91761210 DT.440705 DT.100789441 DT.100789443 DT.91761184 DT.407247 DT.95192753 DT.121317912 DT.92034339 DT.95192756 DT.121317902 DT.121317906 DT.121317926 DT.121317938 DT.91741806 DT.91761185 DT.91761192 DT.100726302 DT.95141563 24/236 AceView cDNA sequences (see all 236): AA306104 NM_145331 AA286771 AI978873 AA461278 CA950641 NM_145333 AA314749 AW137182 AI753351 AW674292 AF218074 AW768930 CD370793 Z41927 AA301405 AA488858 BX364931 BU150117 AB009356 AI473095 BQ958174 BX105101 BM068864
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K7 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | · |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19c |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for MAP3K7
|
Expression
for MAP3K7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAP3K7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCATTGTGT
About this image
See MAP3K7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP3K7
SOURCE GeneReport for Unigene cluster: Hs.594838
UniProtKB/Swiss-Prot: M3K7_HUMAN, O43318Tissue specificity: Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells.Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform1D is the less abundant form
SABiosciences Expression via Pathway-Focused PCR Arrays including MAP3K7 (see all 8):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP3K7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP3K7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K7 |
Orthologs
for MAP3K7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MAP3K7 gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for MAP3K7 (if available)
TreeFam Gene Tree for MAP3K7 (if available) |
Paralogs
for MAP3K7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAP3K7 gene
- MAP3K112 MAP3K122 KIAA18042 RAF12 KSR22 KSR12 BRAF2 MOS2
- MAP3K102 MAP3K92 ARAF2 MAP3K7CL2 TNNI3K2 ZAK2 MAP3K132 ILK2
1 SIMAP similar gene for MAP3K7 using alignment to 1 protein entry: M3K7_HUMAN:DKFZp586F0420
MAP3K7 for paralogs About GeneDecksing
|
Genomic Variants
for MAP3K7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAP3K7 (91223292 - 91296907 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for MAP3K7
1 CNV: 99625
5 Indels: 28383 62545 47180 40888 42986
Locus Specific Mutation Databases (LSDB): MAP3K7
| SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing MAP3K7: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K7 |
|
Disorders
/ Diseases
for MAP3K7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAP3K7 for disorders About GeneDecksing
OMIM gene information: 602614
OMIM disorders: --
20/35  diseases for MAP3K7 (see all 35): About MalaCardshypohidrotic ectodermal dysplasia ectodermal dysplasia cylindromatosis rheumatoid arthritis
chronic lymphocytic leukemia lymphocytic leukemia kaposi's sarcoma kawasaki disease
squamous cell carcinoma celiac disease embryonal carcinoma osteoarthritis
toxoplasmosis breast carcinoma crohn's disease leishmaniasis
arthritis prostate cancer measles vaccinia
10/14 Novoseek disease relationships for MAP3K7 gene (see all 14) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
51.4 |
34 |
19955178 (2), 15647289 (1), 17854800 (1), 19026643 (1) (see all 20) |
| tumors |
35.8 |
35 |
19419968 (3), 19955178 (2), 15647289 (1), 17854800 (1) (see all 18) |
| inflammation |
22.8 |
2 |
16459052 (1), 11129660 (1) |
| adenocarcinoma lung |
8.3 |
1 |
17325661 (1) |
| cancer |
3.73 |
2 |
17172402 (1), 17325661 (1) |
| breast carcinoma |
0 |
1 |
16000313 (1) |
| ischemia |
0 |
1 |
17085580 (1) |
| shock |
0 |
3 |
17202147 (1), 18950863 (1) |
| cancer lung |
0 |
1 |
9466656 (1) |
| breast cancer |
0 |
5 |
18316610 (2), 19049961 (1) |
Human Genome Epidemiology (HuGE) Navigator: MAP3K7 (9 documents)
Export disorders for MAP3K7 gene to outside databases
|
Publications
for MAP3K7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAP3K7 gene, integrated from 9 sources (see all 354):
(articles sorted by number of sources associating them with MAP3K7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. (PubMed id 16893890)1, 2, 9 Huangfu W.C.... Ninomiya-Tsuji J. (2006)
- Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1. (PubMed id 10838074)1, 2, 9 Sakurai H.... Sugita T. (2000)
- Direct activation of protein kinases by unanchored po lyubiquitin chains. (PubMed id 19675569)1, 2, 9 Xia Z.P....Chen Z.J. (2009)
- The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. (PubMed id 18758450)1, 2, 9 Sorrentino A.... Landstrom M. (2008)
- Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. (PubMed id 12242293)1, 2, 9 Jiang Z....Li X. (2002)
- TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. (PubMed id 9079627)1, 2, 9 Shirakabe K....Nishida E. (1997)
- Structural basis for the interaction of TAK1 kinase with its activating protein TAB1. (PubMed id 16289117)1, 2, 9 Brown K....Cheetham G.M.T. (2005)
- TAB3, a new binding partner of the protein kinase TAK1. (PubMed id 14670075)1, 2, 9 Cheung P.C.... Cohen P. (2004)
- Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. (PubMed id 12589052)1, 2, 9 Edlund S.... Landstrom M. (2003)
- The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. (PubMed id 10094049)1, 2, 9 Ninomiya-Tsuji J....Matsumoto K. (1999)
|
External Searches for MAP3K7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAP3K7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAP3K7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAP3K7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAP3K7 gene:
Search GeneIP for patents involving MAP3K7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAP3K7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for MAP3K7 | | OriGene shRNA RFP for MAP3K7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP3K7 | | | OriGene Protein Over-expression Lysate for MAP3K7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAP3K7 | | OriGene 3'-UTR Clone for MAP3K7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MAP3K7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAP3K7 | | OriGene Custom Protein Services for MAP3K7 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP3K7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K7 |
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| | Antibodies & Assays for MAP3K7 (TAK1) |
| | | |  |  |  |  | | | | |
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 | | | MAP3K7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K7 |
|  |  |  | | | | ThermoFisher Antibody for MAP3K7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K7 |
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