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Aliases for MAP3K6 Gene

Aliases for MAP3K6 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 6 2 3
  • MAPKKK6 3 4 6
  • ASK2 3 4 6
  • Apoptosis Signal-Regulating Kinase 2 3 4
  • EC 2.7.11.25 4 63
  • MEKK6 3 4
  • Apoptosis Signal Regulating Kinase 2 2
  • EC 2.7.11 63

External Ids for MAP3K6 Gene

Previous GeneCards Identifiers for MAP3K6 Gene

  • GC01P027901
  • GC01M026713
  • GC01M026914
  • GC01M027286
  • GC01M027554
  • GC01M027681
  • GC01M025937

Summaries for MAP3K6 Gene

Entrez Gene Summary for MAP3K6 Gene

  • This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for MAP3K6 Gene

MAP3K6 (Mitogen-Activated Protein Kinase Kinase Kinase 6) is a Protein Coding gene. Diseases associated with MAP3K6 include familial gastric cancer. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include magnesium ion binding and MAP kinase kinase kinase activity. An important paralog of this gene is MAP3K5.

UniProtKB/Swiss-Prot for MAP3K6 Gene

  • Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K6 Gene

Genomics for MAP3K6 Gene

Regulatory Elements for MAP3K6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAP3K6 Gene

Start:
27,355,179 bp from pter
End:
27,367,054 bp from pter
Size:
11,876 bases
Orientation:
Minus strand

Genomic View for MAP3K6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP3K6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K6 Gene

Proteins for MAP3K6 Gene

  • Protein details for MAP3K6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95382-M3K6_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 6
    Protein Accession:
    O95382
    Secondary Accessions:
    • A2ACE8
    • A2VDG4
    • A2VDG5
    • Q59HF4
    • Q5SSD4
    • Q75PK3
    • Q96B75

    Protein attributes for MAP3K6 Gene

    Size:
    1288 amino acids
    Molecular mass:
    142596 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds both upstream activators and downstream substrates in multimolecular complexes
    SequenceCaution:
    • Sequence=AAD05304.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K6 Gene

Proteomics data for MAP3K6 Gene at MOPED

Selected DME Specific Peptides for MAP3K6 Gene

Post-translational modifications for MAP3K6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K6 Gene

Antibody Products

Domains for MAP3K6 Gene

Gene Families for MAP3K6 Gene

HGNC:
  • MAP3K :Mitogen-activated protein kinase cascade / Kinase kinase kinases
IUPHAR :

Suggested Antigen Peptide Sequences for MAP3K6 Gene

Graphical View of Domain Structure for InterPro Entry

O95382

UniProtKB/Swiss-Prot:

M3K6_HUMAN :
  • O95382
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K6: view

Function for MAP3K6 Gene

Molecular function for MAP3K6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.
UniProtKB/Swiss-Prot Function:
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.

Enzyme Numbers (IUBMB) for MAP3K6 Gene

Gene Ontology (GO) - Molecular Function for MAP3K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 9875215
GO:0004672 protein kinase activity --
GO:0004709 MAP kinase kinase kinase activity IDA 9875215
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IDA 9875215
genes like me logo Genes that share ontologies with MAP3K6: view

Phenotypes for MAP3K6 Gene

genes like me logo Genes that share phenotypes with MAP3K6: view

Animal Model Products

miRNA for MAP3K6 Gene

miRTarBase miRNAs that target MAP3K6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP3K6

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MAP3K6 Gene

Localization for MAP3K6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP3K6 Gene COMPARTMENTS Subcellular localization image for MAP3K6 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAP3K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MAP3K6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K6 Gene

Pathways for MAP3K6 Gene

genes like me logo Genes that share pathways with MAP3K6: view

Pathways by source for MAP3K6 Gene

1 KEGG pathway for MAP3K6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MAP3K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation IDA 9875215
GO:0007165 signal transduction TAS 9875215
GO:0007257 activation of JUN kinase activity TAS 9875215
genes like me logo Genes that share ontologies with MAP3K6: view

Compounds for MAP3K6 Gene

(3) HMDB Compounds for MAP3K6 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with MAP3K6: view

Transcripts for MAP3K6 Gene

Unigene Clusters for MAP3K6 Gene

Mitogen-activated protein kinase kinase kinase 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP3K6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1: -
SP2: - -
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1:
SP2:
SP3:

Relevant External Links for MAP3K6 Gene

GeneLoc Exon Structure for
MAP3K6
ECgene alternative splicing isoforms for
MAP3K6

Expression for MAP3K6 Gene

mRNA expression in normal human tissues for MAP3K6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MAP3K6 Gene

This gene is overexpressed in Breast (19.6), Neutrophil (14.4), Plasma (13.4), and Heart (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP3K6 Gene

SOURCE GeneReport for Unigene cluster for MAP3K6 Gene Hs.194694

genes like me logo Genes that share expressions with MAP3K6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for MAP3K6 Gene

Orthologs for MAP3K6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP3K6 35
  • 88.25 (n)
  • 88.43 (a)
MAP3K6 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP3K6 35
  • 88.37 (n)
  • 89.41 (a)
MAP3K6 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map3k6 35
  • 84.61 (n)
  • 87.68 (a)
Map3k6 16
Map3k6 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAP3K6 35
  • 99.56 (n)
  • 99.53 (a)
MAP3K6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map3k6 35
  • 84.58 (n)
  • 87.52 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP3K6 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K6 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP3K6 35
  • 69.51 (n)
  • 64.16 (a)
MAP3K6 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP3K6 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MAP3K6 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pk92B 37
  • 46 (a)
Pk92B 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nsy-1 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 36
  • 23 (a)
OneToMany
Species with no ortholog for MAP3K6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAP3K6 Gene

ENSEMBL:
Gene Tree for MAP3K6 (if available)
TreeFam:
Gene Tree for MAP3K6 (if available)

Paralogs for MAP3K6 Gene

Paralogs for MAP3K6 Gene

genes like me logo Genes that share paralogs with MAP3K6: view

Variants for MAP3K6 Gene

Sequence variations from dbSNP and Humsavar for MAP3K6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1138294 - 27,362,142(-) CCCCA(C/T)CCAGG reference, missense, nc-transcript-variant
rs3813798 -- 27,361,231(+) CAGCA(G/T)CGCTC synonymous-codon, reference, nc-transcript-variant
rs4075731 -- 27,363,806(-) TTATC(A/C)AATGT intron-variant
rs4307592 -- 27,363,868(-) GTCAG(A/G)CAAAC intron-variant
rs4525067 -- 27,363,272(-) GGGTC(A/G)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K6 Gene

Variant ID Type Subtype PubMed ID
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294
nsv516766 CNV Loss 19592680
dgv204n71 CNV Loss 21882294
nsv870665 CNV Loss 21882294
esv1006916 CNV Deletion 20482838

Relevant External Links for MAP3K6 Gene

HapMap Linkage Disequilibrium report
MAP3K6
Human Gene Mutation Database (HGMD)
MAP3K6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K6 Gene

Disorders for MAP3K6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MAP3K6 Gene in MalaCards »

(1) Diseases for MAP3K6 Gene including...

Relevant External Links for MAP3K6

Genetic Association Database (GAD)
MAP3K6
Human Genome Epidemiology (HuGE) Navigator
MAP3K6
genes like me logo Genes that share disorders with MAP3K6: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MAP3K6 Gene

Publications for MAP3K6 Gene

  1. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen- activated protein kinase kinase kinase in a heteromeric complex with ASK1. (PMID: 17210579) Takeda K. … Ichijo H. (J. Biol. Chem. 2007) 3 4 23
  2. MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. (PMID: 9875215) Wang X.S. … Yao Z. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  3. Heteromeric complex formation of ASK2 and ASK1 regulates stress-induced signaling. (PMID: 17714688) Ortner E. … Moelling K. (Biochem. Biophys. Res. Commun. 2007) 3 23
  4. Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. (PMID: 19246638) Eto N. … Nangaku M. (Am. J. Pathol. 2009) 3 23
  5. ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease. (PMID: 18327563) Arning L. … Epplen J.T. (J. Mol. Med. 2008) 3 48

Products for MAP3K6 Gene

Sources for MAP3K6 Gene

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