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Aliases for MAP3K6 Gene

Aliases for MAP3K6 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 6 2 3
  • MAPKKK6 3 4 6
  • ASK2 3 4 6
  • Apoptosis Signal-Regulating Kinase 2 3 4
  • EC 4 64
  • MEKK6 3 4
  • Apoptosis Signal Regulating Kinase 2 2
  • EC 2.7.11 64

External Ids for MAP3K6 Gene

Summaries for MAP3K6 Gene

Entrez Gene Summary for MAP3K6 Gene

  • This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for MAP3K6 Gene

MAP3K6 (Mitogen-Activated Protein Kinase Kinase Kinase 6) is a Protein Coding gene. Diseases associated with MAP3K6 include familial gastric cancer. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include magnesium ion binding and MAP kinase kinase kinase activity. An important paralog of this gene is MAP3K5.

UniProtKB/Swiss-Prot for MAP3K6 Gene

  • Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K6 Gene

Genomics for MAP3K6 Gene

Genomic Location for MAP3K6 Gene

27,355,179 bp from pter
27,367,054 bp from pter
11,876 bases
Minus strand

Genomic View for MAP3K6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP3K6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K6 Gene

Regulatory Elements for MAP3K6 Gene

Proteins for MAP3K6 Gene

  • Protein details for MAP3K6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 6
    Protein Accession:
    Secondary Accessions:
    • A2ACE8
    • A2VDG4
    • A2VDG5
    • Q59HF4
    • Q5SSD4
    • Q75PK3
    • Q96B75

    Protein attributes for MAP3K6 Gene

    1288 amino acids
    Molecular mass:
    142596 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds both upstream activators and downstream substrates in multimolecular complexes
    • Sequence=AAD05304.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K6 Gene


neXtProt entry for MAP3K6 Gene

Proteomics data for MAP3K6 Gene at MOPED

Selected DME Specific Peptides for MAP3K6 Gene

Post-translational modifications for MAP3K6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K6 Gene

Domains for MAP3K6 Gene

Gene Families for MAP3K6 Gene

  • MAP3K :Mitogen-activated protein kinase cascade / Kinase kinase kinases


  • Contains 1 protein kinase domain.:
    • O95382
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.:
    • O95382
genes like me logo Genes that share domains with MAP3K6: view

Function for MAP3K6 Gene

Molecular function for MAP3K6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.
UniProtKB/Swiss-Prot Function: Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.

Enzyme Numbers (IUBMB) for MAP3K6 Gene

Gene Ontology (GO) - Molecular Function for MAP3K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 9875215
GO:0004672 protein kinase activity --
GO:0004709 MAP kinase kinase kinase activity IDA 9875215
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IDA 9875215
genes like me logo Genes that share ontologies with MAP3K6: view

Phenotypes for MAP3K6 Gene

genes like me logo Genes that share phenotypes with MAP3K6: view

miRNA for MAP3K6 Gene

miRTarBase miRNAs that target MAP3K6

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MAP3K6 Gene

Localization for MAP3K6 Gene

Subcellular locations from

Jensen Localization Image for MAP3K6 Gene COMPARTMENTS Subcellular localization image for MAP3K6 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAP3K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MAP3K6: view

Pathways for MAP3K6 Gene

genes like me logo Genes that share pathways with MAP3K6: view

Pathways by source for MAP3K6 Gene

1 KEGG pathway for MAP3K6 Gene

Gene Ontology (GO) - Biological Process for MAP3K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation IDA 9875215
GO:0007165 signal transduction TAS 9875215
GO:0007257 activation of JUN kinase activity TAS 9875215
genes like me logo Genes that share ontologies with MAP3K6: view

Compounds for MAP3K6 Gene

(3) HMDB Compounds for MAP3K6 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium
genes like me logo Genes that share compounds with MAP3K6: view

Transcripts for MAP3K6 Gene

Unigene Clusters for MAP3K6 Gene

Mitogen-activated protein kinase kinase kinase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1: -
SP2: - -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b

Relevant External Links for MAP3K6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP3K6 Gene

mRNA expression in normal human tissues for MAP3K6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP3K6 Gene

SOURCE GeneReport for Unigene cluster for MAP3K6 Gene Hs.194694

genes like me logo Genes that share expressions with MAP3K6: view

Orthologs for MAP3K6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP3K6 36
  • 99.56 (n)
  • 99.53 (a)
MAP3K6 37
  • 100 (a)
(Bos Taurus)
Mammalia MAP3K6 36
  • 88.25 (n)
  • 88.43 (a)
MAP3K6 37
  • 87 (a)
(Canis familiaris)
Mammalia MAP3K6 36
  • 88.37 (n)
  • 89.41 (a)
MAP3K6 37
  • 89 (a)
(Mus musculus)
Mammalia Map3k6 36
  • 84.61 (n)
  • 87.68 (a)
Map3k6 16
Map3k6 37
  • 87 (a)
(Monodelphis domestica)
Mammalia MAP3K6 37
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia MAP3K6 37
  • 57 (a)
(Rattus norvegicus)
Mammalia Map3k6 36
  • 84.58 (n)
  • 87.52 (a)
(Gallus gallus)
Aves MAP3K6 36
  • 69.51 (n)
  • 64.16 (a)
MAP3K6 37
  • 56 (a)
(Anolis carolinensis)
Reptilia MAP3K6 37
  • 56 (a)
(Danio rerio)
Actinopterygii MAP3K6 37
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pk92B 37
  • 33 (a)
Pk92B 38
  • 46 (a)
(Caenorhabditis elegans)
Secernentea nsy-1 37
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 37
  • 23 (a)
Species with no ortholog for MAP3K6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAP3K6 Gene

Gene Tree for MAP3K6 (if available)
Gene Tree for MAP3K6 (if available)

Paralogs for MAP3K6 Gene

Paralogs for MAP3K6 Gene

genes like me logo Genes that share paralogs with MAP3K6: view

Variants for MAP3K6 Gene

Sequence variations from dbSNP and Humsavar for MAP3K6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1138294 - 27,362,142(-) CCCCA(C/T)CCAGG reference, missense, nc-transcript-variant
rs3813798 -- 27,361,231(+) CAGCA(G/T)CGCTC synonymous-codon, reference, nc-transcript-variant
rs4075731 -- 27,363,806(-) TTATC(A/C)AATGT intron-variant
rs4307592 -- 27,363,868(-) GTCAG(A/G)CAAAC intron-variant
rs4525067 -- 27,363,272(-) GGGTC(A/G)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K6 Gene

Variant ID Type Subtype PubMed ID
nsv526051 CNV Gain 19592680
dgv203n71 CNV Loss 21882294
nsv516766 CNV Loss 19592680
dgv204n71 CNV Loss 21882294
nsv870665 CNV Loss 21882294
esv1006916 CNV Deletion 20482838

Relevant External Links for MAP3K6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for MAP3K6 Gene

(1) MalaCards Diseases for MAP3K6 Gene

Search for MAP3K6 Gene in MalaCards »

Relevant External Links for MAP3K6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAP3K6: view

No data available for UniProtKB/Swiss-Prot for MAP3K6 Gene

Publications for MAP3K6 Gene

  1. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen- activated protein kinase kinase kinase in a heteromeric complex with ASK1. (PMID: 17210579) Takeda K. … Ichijo H. (J. Biol. Chem. 2007) 3 4 23
  2. MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. (PMID: 9875215) Wang X.S. … Yao Z. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  3. Heteromeric complex formation of ASK2 and ASK1 regulates stress-induced signaling. (PMID: 17714688) Ortner E. … Moelling K. (Biochem. Biophys. Res. Commun. 2007) 3 23
  4. Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. (PMID: 19246638) Eto N. … Nangaku M. (Am. J. Pathol. 2009) 3 23
  5. ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease. (PMID: 18327563) Arning L. … Epplen J.T. (J. Mol. Med. 2008) 3 49

Products for MAP3K6 Gene

Sources for MAP3K6 Gene

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