Aliases for MAP3K6 Gene
External Ids for MAP3K6 Gene
Previous GeneCards Identifiers for MAP3K6 Gene
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for MAP3K6 Gene
MAP3K6 (Mitogen-Activated Protein Kinase Kinase Kinase 6) is a Protein Coding gene. Diseases associated with MAP3K6 include familial gastric cancer. Among its related pathways are MAPK signaling pathway and MAPK signaling pathway. GO annotations related to this gene include magnesium ion binding and MAP kinase kinase kinase activity. An important paralog of this gene is MAP3K5.
UniProtKB/Swiss-Prot for MAP3K6 Gene
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.