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Aliases for MAP3K6 Gene

Aliases for MAP3K6 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 6 2 3 5
  • Apoptosis Signal-Regulating Kinase 2 3 4
  • EC 2.7.11.25 4 58
  • MAPKKK6 3 4
  • MEKK6 3 4
  • ASK2 3 4
  • Apoptosis Signal Regulating Kinase 2 2
  • EC 2.7.11 58

External Ids for MAP3K6 Gene

Previous GeneCards Identifiers for MAP3K6 Gene

  • GC01P027901
  • GC01M026713
  • GC01M026914
  • GC01M027286
  • GC01M027554
  • GC01M027681
  • GC01M025937

Summaries for MAP3K6 Gene

Entrez Gene Summary for MAP3K6 Gene

  • This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for MAP3K6 Gene

MAP3K6 (Mitogen-Activated Protein Kinase Kinase Kinase 6) is a Protein Coding gene. Diseases associated with MAP3K6 include Gastric Cancer Risk After H. Pylori Infection. Among its related pathways are p38 MAPK signaling pathway (Pathway Interaction Database) and Type I Interferon Signaling Pathways. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K5.

UniProtKB/Swiss-Prot for MAP3K6 Gene

  • Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.

Additional gene information for MAP3K6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K6 Gene

Genomics for MAP3K6 Gene

Regulatory Elements for MAP3K6 Gene

Enhancers for MAP3K6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H027516 2.1 FANTOM5 Ensembl ENCODE dbSUPER 41.1 -155.8 -155800 13 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A ARID4B DMAP1 ZNF2 YY1 ACTG1P20 ARID1A MAP3K6 FAM76A PHACTR4 NPM1P39 WASF2 GPN2 ENSG00000231344 EYA3
GH01H027487 1.4 ENCODE dbSUPER 43.3 -122.7 -122701 5 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 MCM3 ARID1A ACTG1P20 FAM76A GPN2 PHACTR4 NPM1P39 MAP3K6 PPP1R8 ENSG00000231344 LOC101928728
GH01H027026 1.6 FANTOM5 Ensembl ENCODE 31.5 +340.4 340415 2 HDGF ATF1 FOXA2 ARNT ZFP64 FEZF1 ZNF2 TCF12 KLF7 ATF7 ARID1A ACTG1P20 HMGN2 GPN2 MAP3K6 LOC101928324 FAM76A RPL17P9 PPP1R8 ENSG00000231344
GH01H027866 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.2 -500.6 -500626 3 HNRNPUL1 HDGF PKNOX1 ATF1 ARNT TCF12 GTF3C2 ZNF766 GATA2 ELK1 XKR8 GMEB1 YTHDF2 SNHG12 TRNAU1AP NPM1P39 GPN2 MAP3K6 WASF2 THEMIS2
GH01H026691 3.2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +671.0 670957 12 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 ARID1A HMGN2 LOC101928324 PIGV ACTG1P20 LOC101928728 GPN2 GPATCH3 TMEM222 LOC105376890
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP3K6 on UCSC Golden Path with GeneCards custom track

Promoters for MAP3K6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003703 1814 1601 HDGF ARNT ARID4B ZNF2 GLIS2 ZNF143 KLF7 ATF7 SP3 SP5

Genomic Location for MAP3K6 Gene

Chromosome:
1
Start:
27,355,179 bp from pter
End:
27,368,014 bp from pter
Size:
12,836 bases
Orientation:
Minus strand

Genomic View for MAP3K6 Gene

Genes around MAP3K6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K6 Gene

Proteins for MAP3K6 Gene

  • Protein details for MAP3K6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95382-M3K6_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 6
    Protein Accession:
    O95382
    Secondary Accessions:
    • A2ACE8
    • A2VDG4
    • A2VDG5
    • Q59HF4
    • Q5SSD4
    • Q75PK3
    • Q96B75

    Protein attributes for MAP3K6 Gene

    Size:
    1288 amino acids
    Molecular mass:
    142596 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds both upstream activators and downstream substrates in multimolecular complexes.
    SequenceCaution:
    • Sequence=AAD05304.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K6 Gene

Selected DME Specific Peptides for MAP3K6 Gene

O95382:
  • NIVRYLG
  • QDPLAVA
  • VPGGSLS
  • NLLLSYRD
  • KISDFGTSK

Post-translational modifications for MAP3K6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K6 Gene

Domains & Families for MAP3K6 Gene

Gene Families for MAP3K6 Gene

Suggested Antigen Peptide Sequences for MAP3K6 Gene

Graphical View of Domain Structure for InterPro Entry

O95382

UniProtKB/Swiss-Prot:

M3K6_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K6: view

Function for MAP3K6 Gene

Molecular function for MAP3K6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.
UniProtKB/Swiss-Prot Function:
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.

Enzyme Numbers (IUBMB) for MAP3K6 Gene

Phenotypes From GWAS Catalog for MAP3K6 Gene

Gene Ontology (GO) - Molecular Function for MAP3K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 9875215
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004709 MAP kinase kinase kinase activity TAS,IDA 9875215
GO:0005524 ATP binding IDA 9875215
genes like me logo Genes that share ontologies with MAP3K6: view
genes like me logo Genes that share phenotypes with MAP3K6: view

Animal Models for MAP3K6 Gene

MGI Knock Outs for MAP3K6:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAP3K6

CRISPR Products

miRNA for MAP3K6 Gene

miRTarBase miRNAs that target MAP3K6

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAP3K6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K6 Gene

Localization for MAP3K6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K6 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP3K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with MAP3K6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K6 Gene

Pathways & Interactions for MAP3K6 Gene

genes like me logo Genes that share pathways with MAP3K6: view

Gene Ontology (GO) - Biological Process for MAP3K6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation IDA 9875215
GO:0007165 signal transduction TAS 9875215
GO:0007257 activation of JUN kinase activity TAS 9875215
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP3K6: view

No data available for SIGNOR curated interactions for MAP3K6 Gene

Drugs & Compounds for MAP3K6 Gene

(2) Drugs for MAP3K6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Nutra Agonist 0
Magnesium Nutra 0

(1) Additional Compounds for MAP3K6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAP3K6: view

Transcripts for MAP3K6 Gene

Unigene Clusters for MAP3K6 Gene

Mitogen-activated protein kinase kinase kinase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAP3K6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1: -
SP2: - -
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1:
SP2:
SP3:

Relevant External Links for MAP3K6 Gene

GeneLoc Exon Structure for
MAP3K6
ECgene alternative splicing isoforms for
MAP3K6

Expression for MAP3K6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP3K6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP3K6 Gene

This gene is overexpressed in Breast (19.6), Neutrophil (14.4), Plasma (13.4), and Heart (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP3K6 Gene



NURSA nuclear receptor signaling pathways regulating expression of MAP3K6 Gene:

MAP3K6

SOURCE GeneReport for Unigene cluster for MAP3K6 Gene:

Hs.194694

Evidence on tissue expression from TISSUES for MAP3K6 Gene

  • Skin(4.3)
  • Nervous system(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K6 Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
Organs:
Abdomen:
  • stomach
genes like me logo Genes that share expression patterns with MAP3K6: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MAP3K6 Gene

Orthologs for MAP3K6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP3K6 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia MAP3K6 33 34
  • 88.37 (n)
cow
(Bos Taurus)
Mammalia MAP3K6 33 34
  • 88.25 (n)
mouse
(Mus musculus)
Mammalia Map3k6 33 16 34
  • 84.61 (n)
rat
(Rattus norvegicus)
Mammalia Map3k6 33
  • 84.58 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP3K6 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K6 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP3K6 33 34
  • 69.51 (n)
lizard
(Anolis carolinensis)
Reptilia MAP3K6 34
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MAP3K6 34
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pk92B 35 34
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea nsy-1 34
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 34
  • 23 (a)
OneToMany
Species where no ortholog for MAP3K6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAP3K6 Gene

ENSEMBL:
Gene Tree for MAP3K6 (if available)
TreeFam:
Gene Tree for MAP3K6 (if available)

Paralogs for MAP3K6 Gene

Paralogs for MAP3K6 Gene

genes like me logo Genes that share paralogs with MAP3K6: view

Variants for MAP3K6 Gene

Sequence variations from dbSNP and Humsavar for MAP3K6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035629 A breast cancer sample
VAR_046054 A breast pleomorphic lobular carcinoma sample
VAR_046055 An ovarian endometrioid cancer sample
rs1000284785 -- 27,356,168(+) ACCAA(C/T)AGTGT intron-variant, downstream-variant-500B
rs1000847152 -- 27,360,598(+) GGTCC(C/T)ACGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K6 Gene

Variant ID Type Subtype PubMed ID
esv1006916 CNV deletion 20482838
nsv1075766 CNV deletion 25765185
nsv516766 CNV loss 19592680
nsv526051 CNV gain 19592680

Variation tolerance for MAP3K6 Gene

Residual Variation Intolerance Score: 36.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.35; 92.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K6 Gene

Human Gene Mutation Database (HGMD)
MAP3K6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K6 Gene

Disorders for MAP3K6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP3K6 Gene - From: Orphanet

Disorder Aliases PubMed IDs
gastric cancer risk after h. pylori infection
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAP3K6

Genetic Association Database (GAD)
MAP3K6
Human Genome Epidemiology (HuGE) Navigator
MAP3K6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K6
genes like me logo Genes that share disorders with MAP3K6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP3K6 Gene

Publications for MAP3K6 Gene

  1. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. (PMID: 17210579) Takeda K … Ichijo H (The Journal of biological chemistry 2007) 3 4 22 60
  2. MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. (PMID: 9875215) Wang XS … Yao Z (Biochemical and biophysical research communications 1998) 2 3 4 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. (PMID: 19246638) Eto N … Nangaku M (The American journal of pathology 2009) 3 22 60
  5. ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease. (PMID: 18327563) Arning L … Epplen JT (Journal of molecular medicine (Berlin, Germany) 2008) 3 45 60

Products for MAP3K6 Gene

Sources for MAP3K6 Gene

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