Aliases for MAP3K6 Gene
External Ids for MAP3K6 Gene
Previous GeneCards Identifiers for MAP3K6 Gene
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for MAP3K6 Gene
MAP3K6 (Mitogen-Activated Protein Kinase Kinase Kinase 6) is a Protein Coding gene. Diseases associated with MAP3K6 include familial gastric cancer. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include magnesium ion binding and MAP kinase kinase kinase activity. An important paralog of this gene is MAP3K5.
UniProtKB/Swiss-Prot for MAP3K6 Gene
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.