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MAP3K6 Gene

protein-coding   GIFtS: 61
GCID: GC01M027681

Mitogen-Activated Protein Kinase Kinase Kinase 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 61 2     Apoptosis Signal-Regulating Kinase 22 3
ASK22 3 5     MEKK62 3
MAPKKK62 3 5     EC 2.7.11.253 8
Apoptosis Signal Regulating Kinase 21 2     EC 2.7.118

External Ids:    HGNC: 68581   Entrez Gene: 90642   Ensembl: ENSG000001427337   OMIM: 6044685   UniProtKB: O953823   

Export aliases for MAP3K6 gene to outside databases

Previous GC identifers: GC01P027901 GC01M026713 GC01M026914 GC01M027286 GC01M027365 GC01M027554 GC01M025937


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP3K6 Gene:
This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its
interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase.
This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript
variant has been found for this gene, but its biological validity has not been determined. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MAP3K6 Gene:
MAP3K6 (mitogen-activated protein kinase kinase kinase 6) is a protein-coding gene. GO annotations related to this gene include magnesium ion binding and MAP kinase kinase kinase activity. An important paralog of this gene is MAP3K1.

UniProtKB/Swiss-Prot: M3K6_HUMAN, O95382
Function: Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase
pathways




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP3K6 gene promoter:
         Elk-1   p53   STAT5A   Tal-1beta   YY1   MZF-1   AREB6   SEF-1 (1)   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP3K6 promoter sequence
   Search Chromatin IP Primers for MAP3K6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP3K6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

MAP3K6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M027681:  view genomic region     (about GC identifiers)

Start:
27,681,670 bp from pter      End:
27,693,383 bp from pter
Size:
11,714 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: M3K6_HUMAN, O95382 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 6  
Size: 1288 amino acids; 142596 Da
Cofactor: Magnesium (By similarity)
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes
Sequence caution: Sequence=AAD05304.1; Type=Erroneous initiation;
Secondary accessions: A2ACE8 A2VDG4 A2VDG5 Q59HF4 Q5SSD4 Q75PK3 Q96B75
Alternative splicing: 3 isoforms:  O95382-1   O95382-2   O95382-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP3K6: NX_O95382

Explore proteomics data for MAP3K6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP3K6 (O95382) (see all 5)
     VPGGSLS  NIVRYLG  QDPLAVA  NLLLSYRD 


    See MAP3K6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004663.3  
    ENSEMBL proteins: 
     ENSP00000418932   ENSP00000418731   ENSP00000363152   ENSP00000419591   ENSP00000350195  

    MAP3K6 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP3K6

     
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    antibodies-online proteins for MAP3K6 (2 products) 

     
    antibodies-online peptides for MAP3K6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 6
    STE11 family

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR025136 DUF4071

    Graphical View of Domain Structure for InterPro Entry O95382

    ProtoNet protein and cluster: O95382

    UniProtKB/Swiss-Prot: M3K6_HUMAN, O95382
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAP3K6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K6_HUMAN, O95382
    Function: Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase
    pathways
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5,
    with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by
    direct phosphorylation

         Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA9875215
    GO:0004672protein kinase activity ----
    GO:0004709MAP kinase kinase kinase activity IDA9875215
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IDA9875215
         
    Find genes that share ontologies with MAP3K6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MAP3K6:
     Decreased substrate adherent c 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Map3k6):
     cellular  homeostasis/metabolism  integument  tumorigenesis 

    Find genes that share phenotypes with MAP3K6           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MAP3K6

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP3K6:
    hsa-mir-92a-3p (MIRT049479)

    Block miRNA regulation of human, mouse, rat MAP3K6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MAP3K6:
    hsa-miR-136
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP3K6
    Predesigned siRNA for gene silencing in human, mouse, rat MAP3K6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MAP3K6 (NM_004672)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K6
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    Addgene plasmids for MAP3K6 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--

    Find genes that share ontologies with MAP3K6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP3K6 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    TCR Signaling0.68
    3TGF-Beta Pathway
    MAPK Family Pathway0.60
    4G-Beta Gamma Signaling
    CRHR Pathway0.44
    5NFAT and Cardiac Hypertrophy
    NFAT and Cardiac Hypertrophy0.42


    Find genes that share SuperPaths with MAP3K6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP3K6 (see all 9)
        Interferon Pathway
    CRHR Pathway
    TNFR2 Pathway
    NFAT and Cardiac Hypertrophy
    MAPK Family Pathway

    3 BioSystems Pathways for MAP3K6
        MAPK signaling pathway
    Insulin Signaling
    p38 MAPK signaling pathway


    1 Kegg Pathway  (Kegg details for MAP3K6):
        MAPK signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including MAP3K6: 
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP3K6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP3K6 (O953822, 3 ENSP000003501954) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-8009438 I2D: score=2 STRING: ENSP00000306330
    MAP3K5Q996833, ENSP000003519084I2D: score=5 STRING: ENSP00000351908
    PRKAA2P546463, ENSP000003602904I2D: score=3 STRING: ENSP00000360290
    PRKAB2O437413, ENSP000002541014I2D: score=3 STRING: ENSP00000254101
    NUB1Q9Y5A73I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IDA9875215
    GO:0006468protein phosphorylation IDA9875215
    GO:0007165signal transduction TAS9875215
    GO:0007257activation of JUN kinase activity TAS9875215

    Find genes that share ontologies with MAP3K6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP3K6 (M3K6)

    3 HMDB Compounds for MAP3K6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAP3K6 gene: 
    NM_004672.3  

    Unigene Cluster for MAP3K6:

    Mitogen-activated protein kinase kinase kinase 6
    Hs.194694  [show with all ESTs]
    Unigene Representative Sequence: NM_004672
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486046 ENST00000472410(uc001bnz.1) ENST00000374040(uc001bny.1 uc009vsw.1)
    ENST00000493901 ENST00000470890 ENST00000357582 ENST00000476509 ENST00000495230

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate MAP3K6:
    hsa-miR-136
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K6 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: MAP3K6 (NM_004672)
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    Addgene plasmids for MAP3K6 
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      QuantiTect SYBR Green Assays in human, mouse, rat MAP3K6
      QuantiFast Probe-based Assays in human, mouse, rat MAP3K6

    Additional mRNA sequence: 

    AB167411.1 AB208805.1 AF100318.1 BC015914.1 BC109032.2 BC129950.1 BC129951.1 

    7 DOTS entries:

    DT.99992788  DT.100678279  DT.442961  DT.97798447  DT.95271916  DT.95333729  DT.97816339 

    Selected AceView cDNA sequences (see all 121):

    CD672130 BM692866 BM839781 BM708536 AW008959 BU149591 CR623497 BU733101 
    BQ917365 BU730230 BE206006 BG681930 AA418001 AB167411 CA414892 BQ673742 
    BQ947943 BF732392 AW771625 BI824474 BQ219831 BU730833 BC015914 BU149467 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
    SP1:                                                                                                                                                  -         
    SP2:                    -                                                                                                                             -         
    SP3:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:                                    
    SP2:                                    
    SP3:                                    


    ECgene alternative splicing isoforms for MAP3K6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP3K6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGAGCT
    MAP3K6 Expression
    About this image


    MAP3K6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Ovary (Reproductive System)
             Secondary follicles
    MAP3K6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP3K6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194694
        Pathway & Disease-focused RT2 Profiler PCR Array including MAP3K6: 
              Hepatotoxicity in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAP3K6
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    QuantiFast Probe-based Assays in human, mouse, rat MAP3K6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP3K6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k61 , 5 mitogen-activated protein kinase kinase kinase 61, 5 84.61(n)1
    87.68(a)1
      4 (66.25 cM)5
    536081  NM_016693.51  NP_057902.51 
     1332408185 
    chicken
    (Gallus gallus)
    Aves MAP3K61 mitogen-activated protein kinase kinase kinase 6 69.51(n)
    64.16(a)
      100858193  XM_003642565.2  XP_003642613.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K66
    mitogen-activated protein kinase kinase kinase 6
    56(a)
    1 ↔ 1
    GL343464.1(254789-329955)
    zebrafish
    (Danio rerio)
    Actinopterygii MAP3K66
    mitogen-activated protein kinase kinase kinase 6
    48(a)
    1 ↔ 1
    16(39567672-39617813) ENSDARG00000069933
    fruit fly
    (Drosophila melanogaster)
    Insecta Pk92B3 protein amino acid phosphorylation
    receptor signaling more
    46(a)   3 92B4   --
    worm
    (Caenorhabditis elegans)
    Secernentea nsy-16
    Protein NSY-1
    30(a)
    1 → many
    II(5022764-5029982) WBGene00003822
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE116
    Signal transducing MEK kinase involved in pheromon...
    23(a)
    1 → many
    XII(849866-852019) YLR362W


    ENSEMBL Gene Tree for MAP3K6 (if available)
    TreeFam Gene Tree for MAP3K6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP3K6 gene
    MAP3K12  MAP3K32  MAP3K52  MAP3K152  MAP3K82  MAP3K22  MAP3K192  
    Selected SIMAP similar genes for MAP3K6 using alignment to 5 protein entries:     M3K6_HUMAN (see all proteins) (see all similar genes):
    MAP3K5    MAP3K15    BRAF    MAP3K19    MAP3K2    MAPK8
    MST094    NEK6    MARK4    STK25    SELENBP1    CCRK
    DKFZp564L2416    PAK2    PKN2    PRKY    RPS6KA2    STK11

    Find genes that share paralogs with MAP3K6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP3K6 (see all 479)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0460554
    An ovarian endometrioid cancer sample4--see VAR_0460552 T I mis40--------
    VAR_0356294
    A breast cancer sample4--see VAR_0356292 P T mis40--------
    VAR_0460544
    A breast pleomorphic lobular carcinoma sample4--see VAR_0460542 S L mis40--------
    rs777002781,2
    F--27681233(+) AGTGCT/GGGGAT 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1472153681,2
    C--27681339(+) TGGAGC/TGCAGT 1 -- ds50010--------
    rs1863451701,2
    --27681351(+) GCGCAA/GTCTCG 1 -- ds50010--------
    rs1899085801,2
    --27681372(+) AGCTCC/TGCCTC 1 -- ds50010--------
    rs1807102141,2
    C--27681424(+) TGGGAC/TTACAG 1 -- ds50010--------
    rs1407567661,2
    C--27681444(+) AGCACA/GCCCAG 1 -- ds50010--------
    rs1117558601,2
    C--27681478(+) GAGACG/AGGGTT 1 -- ds50011Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for MAP3K6 (27681670 - 27693383 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MAP3K6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1006916CNV Deletion20482838
    nsv516766CNV Loss19592680
    nsv870665CNV Loss21882294
    dgv204n71CNV Loss21882294
    dgv203n71CNV Loss21882294
    nsv526051CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MAP3K6
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604468    OMIM disorders: --


    Find genes that share disorders with MAP3K6           About GenesLikeMe

    Genetic Association Database (GAD): MAP3K6
    Human Genome Epidemiology (HuGE) Navigator: MAP3K6 (5 documents)

    Export disorders for MAP3K6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP3K6 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with MAP3K6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. (PubMed id 9875215)1, 2, 3 Wang X.S.... Yao Z. (Biochem. Biophys. Res. Commun. 1998)
    2. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen- activated protein kinase kinase kinase in a heteromeric complex with ASK1. (PubMed id 17210579)1, 2, 9 Takeda K.... Ichijo H. (J. Biol. Chem. 2007)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease. (PubMed id 18327563)1, 4 Arning L....Epplen J.T. (J. Mol. Med. 2008)
    5. Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. (PubMed id 19246638)1, 9 Eto N....Nangaku M. (Am. J. Pathol. 2009)
    6. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9064 HGNC: 6858 AceView: MAP3K6 Ensembl:ENSG00000142733 euGenes: HUgn9064
    ECgene: MAP3K6 Kegg: 9064 H-InvDB: MAP3K6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP3K6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP3K6 gene:
    Search GeneIP for patents involving MAP3K6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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