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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K6 Gene

protein-coding   GIFtS: 59
GCID: GC01M027681

mitogen-activated protein kinase kinase kinase 6
 Explore 4 diseases affiliated with
MAP3K6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP3K6    

Aliases
for MAP3K6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 61 2     Apoptosis Signal-Regulating Kinase 22 3
ASK21 2 3     EC 2.7.11.253 8
MAPKKK61 2 3     Apoptosis Signal Regulating Kinase 22
MEKK61 2 3     EC 2.7.118

External Ids:    HGNC: 68581   Entrez Gene: 90642   Ensembl: ENSG000001427337   OMIM: 6044685   UniProtKB: O953823   

Export aliases for MAP3K6 gene to outside databases

Previous GC identifers: GC01P027901 GC01M026713 GC01M026914 GC01M027286 GC01M027365 GC01M027554 GC01M025937


Summaries
for MAP3K6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAP3K6:
This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its
interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This
kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant
has been found for this gene, but its biological validity has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: M3K6_HUMAN, O95382
Function: Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase
pathways




Genomic Views
for MAP3K6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K6 gene promoter:
         Elk-1   p53   STAT5A   Tal-1beta   YY1   MZF-1   AREB6   SEF-1 (1)   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAP3K6 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP3K6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

MAP3K6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M027681:  view genomic region     (about GC identifiers)

Start:
 27,681,670 bp from pter      End:
 27,693,383 bp from pter
Size:
 11,714 bases      Orientation:
 minus strand

Proteins
for MAP3K6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: M3K6_HUMAN, O95382 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 6  
Size: 1288 amino acids; 142596 Da
Cofactor: Magnesium (By similarity)
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes
Sequence caution: Sequence=AAD05304.1; Type=Erroneous initiation;
Secondary accessions: A2ACE8 A2VDG4 A2VDG5 Q59HF4 Q5SSD4 Q75PK3 Q96B75
Alternative splicing: 3 isoforms:  O95382-1   O95382-2   O95382-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP3K6: NX_O95382

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95382

    • 4/5 DME Specific Peptides for MAP3K6 (O95382) (see all 5)
     VPGGSLS  NIVRYLG  QDPLAVA  NLLLSYRD 

    MAP3K6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004663.3  
    ENSEMBL proteins: 
     ENSP00000418731   ENSP00000418932   ENSP00000419591   ENSP00000350195   ENSP00000363152  

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    Uscn Proteins for MAP3K6


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    Uscn ELISAs and CLIAs for MAP3K6

    Protein Domains /
    Families
    for MAP3K6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP3K6 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR025136 DUF4071

    Graphical View of Domain Structure for InterPro Entry O95382

    ProtoNet protein and cluster: O95382

    UniProtKB/Swiss-Prot: M3K6_HUMAN, O95382
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAP3K6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: M3K6_HUMAN, O95382
    Function: Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase
    pathways
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with
    MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct
    phosphorylation

    Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

    miRNA
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    hsa-miR-136
    SwitchGear 3'UTR luciferase reporter plasmid: MAP3K6 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for MAP3K6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K6

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA9875215
    GO:0004709MAP kinase kinase kinase activity IDA9875215
    GO:0005515protein binding ----
    GO:0005524ATP binding IDA9875215


    MAP3K6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MAP3K6:
     Decreased substrate adherent c 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Map3k6):
     cellular  homeostasis/metabolism  integument  tumorigenesis 

    MAP3K6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAP3K6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    2PKC-Theta Pathway
    		PKC-Theta Pathway1.00
    		TCR Signaling0.68
    3WNT Signaling
    		WNT Signaling1.00
    4NFAT and Cardiac Hypertrophy
    		NFAT and Cardiac Hypertrophy1.00
    5Interferon Pathway
    		Interferon Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K6 (see all 9)
        Interferon Pathway
    CRHR Pathway
    TNFR2 Pathway
    NFAT and Cardiac Hypertrophy
    MAPK Family Pathway

    3 BioSystems Pathways for MAP3K6 
        MAPK signaling pathway
    Insulin Signaling
    p38 MAPK signaling pathway


    1         Kegg Pathway  (Kegg details for MAP3K6):
        MAPK signaling pathway


    MAP3K6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/15 Interacting proteins for MAP3K6 (O953822, 3 ENSP000003501954) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-8009438 I2D: score=2 STRING: ENSP00000306330
    MAP3K5Q996833, ENSP000003519084I2D: score=5 STRING: ENSP00000351908
    PRKAA2P546463, ENSP000003602904I2D: score=3 STRING: ENSP00000360290
    PRKAB2O437413, ENSP000002541014I2D: score=3 STRING: ENSP00000254101
    NUB1Q9Y5A73I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000186activation of MAPKK activity IDA9875215
    GO:0006468protein phosphorylation IDA9875215
    GO:0007165signal transduction TAS9875215
    GO:0007257activation of JUN kinase activity TAS9875215


    MAP3K6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP3K6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP3K6

    3 HMDB Compounds for MAP3K6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about MAP3K6 / M3K6 

    Transcripts
    for MAP3K6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP3K6 gene: 
    NM_004672.3  

    Unigene Cluster for MAP3K6:

    Mitogen-activated protein kinase kinase kinase 6
    Hs.194694  [show with all ESTs]
    Unigene Representative Sequence: NM_004672
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472410(uc001bnz.1) ENST00000486046 ENST00000493901 ENST00000470890
    ENST00000357582 ENST00000476509 ENST00000495230 ENST00000374040(uc001bny.1 uc009vsw.1)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K6
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MAP3K6:
    hsa-miR-136
    SwitchGear 3'UTR luciferase reporter plasmid: MAP3K6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K6 (see all 7)
    OriGene shRNA RFP: MAP3K6
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K6
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K6
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    Additional cDNA sequence: 

    AB167411.1 AB208805.1 AF100318.1 BC015914.1 BC109032.2 BC129950.1 BC129951.1 

    7 DOTS entries:

    DT.99992788  DT.100678279  DT.442961  DT.97798447  DT.95271916  DT.95333729  DT.97816339 

    24/121 AceView cDNA sequences (see all 121):

    AW008959 BM708536 BC015914 BU528275 BM839781 BQ917365 BU149591 BF732392 
    BM694233 BQ219831 BM810285 BU733101 BU149467 BQ073815 BU730833 AW771625 
    BI824474 BQ947943 CD672130 CR623497 BQ673742 BE206006 BG681930 AA418001 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
    SP1:                                                                                                                                                  -         
    SP2:                    -                                                                                                                             -         
    SP3:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:                                    
    SP2:                                    
    SP3:                                    


    ECgene alternative splicing isoforms for MAP3K6

    Expression
    for MAP3K6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGAAGAGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAP3K6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Secondary follicles (Primary Cell)Ovary, Reproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAP3K6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K6

    SOURCE GeneReport for Unigene cluster: Hs.194694
        SABiosciences Expression via Pathway-Focused PCR Array including MAP3K6: 
              Hepatotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for MAP3K6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP3K6 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAP3K61 mitogen-activated protein kinase kinase kinase 6 66.97(n)
    60.96(a)    		   100858193  XM_003642565.1  XP_003642613.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAP3K66
    		 --
    		 54(a)
    		 1 ↔ 1
    		 GL343464.1(256181-306352)
    zebrafish
    (Danio rerio)    		 Actinopterygii wu:fa92h046
    		 wu:fa92h04
    		 47(a)
    		 1 ↔ 1
    		 16(39567731-39617813)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pk92B3 protein amino acid phosphorylation receptor
    signaling more    		 46(a)   3 92B4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea nsy-16
    		 Neuronal Symmetry family member (nsy-1)
    		 28(a)
    		 1 → many
    		 II(5022756-5029974)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G342906
    AT2G425506
    (see all 26)    		 protein kinase-like protein
    (see all 26)    		 31(a)
    26(a)
    (see all 26)    		 possible ortholog
    possible ortholog
    (see all 26)    		 2(14472633-14473430)
    2(17713196-17714230)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 11)    		 STE_MEKK_ste11_MAP3K.11 - STE kinases include homo...
    STE_MEKK_ste11_MAP3K.8 - STE kinases include homol...
    (see all 11)    		 35(a)
    24(a)
    (see all 11)    		 possible ortholog
    possible ortholog
    (see all 11)    		 2(32455259-32456963)
    2(12893454-12895429)


    ENSEMBL Gene Tree for MAP3K6 (if available)
    TreeFam Gene Tree for MAP3K6 (if available) 

    Paralogs
    for MAP3K6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP3K6 gene
    MAP3K12  MAP3K32  MAP3K52  MAP3K152  MAP3K192  MAP3K22  MAP3K82  
    18/28 SIMAP similar genes for MAP3K6 using alignment to 6 protein entries:     M3K6_HUMAN (see all proteins) (see all similar genes):
    MAP3K5    MAP3K15    BRAF    MAP3K19    MAP3K2    MAPK8
    MST094    NEK6    MARK4    STK25    CCRK    DKFZp564L2416
    PAK2    PKN2    PRKY    RPS6KA2    STK11    NEK3

    MAP3K6 for paralogs           About GeneDecksing



    Genomic Variants
    for MAP3K6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/310 NCBI SNPs in MAP3K6 are shown (see all 310)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs777002781,2
    		--27681233(+) AGTGCT/GGGGAT 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1472153681,2
    		--27681339(+) TGGAGC/TGCAGT 1 -- ds50010--------
    rs1863451701,2
    		--27681351(+) GCGCAA/GTCTCG 1 -- ds50010--------
    rs1899085801,2
    		--27681372(+) AGCTCC/TGCCTC 1 -- ds50010--------
    rs1807102141,2
    		--27681424(+) TGGGAC/TTACAG 1 -- ds50010--------
    rs1407567661,2
    		--27681444(+) AGCACA/GCCCAG 1 -- ds50010--------
    rs1446196341,2
    		--27681487(+) TTTCAC/GCATGT 1 -- ds50010--------
    rs1863544241,2
    		--27681489(+) TCAGCA/GTGTTA 1 -- ds50010--------
    rs1115313261,2
    		--27681494(+) ATGTTG/AGCCAG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1120105951,2
    		--27681503(+) AGGATG/AGTCTT 1 -- ds50011Minor allele frequency- A:0.00CSA 1

    HapMap Linkage Disequilibrium report for MAP3K6 (27681670 - 27693383 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MAP3K6
         1 CNV: 48306

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MAP3K6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP3K6 for disorders           About GeneDecksing

    OMIM gene information: 604468    OMIM disorders: --

    4 diseases for MAP3K6:    About MalaCards
    huntington's disease    ovarian cancer    leukemia    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: MAP3K6 (5 documents)

    Export disorders for MAP3K6 gene to outside databases

    Publications
    for MAP3K6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K6 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with MAP3K6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5. (PubMed id 9875215)1, 2, 3 Wang X.S.... Yao Z. (1998)
    2. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen- activated protein kinase kinase kinase in a heteromeric complex with ASK1. (PubMed id 17210579)1, 2, 9 Takeda K.... Ichijo H. (2007)
    3. Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. (PubMed id 19246638)1, 9 Eto N....Nangaku M. (2009)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)

    External Searches for MAP3K6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing MAP3K6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9064 HGNC: 6858 AceView: MAP3K6 Ensembl:ENSG00000142733 euGenes: HUgn9064
    ECgene: MAP3K6 Kegg: 9064 H-InvDB: MAP3K6

    Other Databases showing MAP3K6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAP3K6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAP3K6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP3K6 gene:
    Search GeneIP for patents involving MAP3K6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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