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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K4 Gene

protein-coding   GIFtS: 65
GCID: GC06P161412

mitogen-activated protein kinase kinase kinase 4


(Previous symbol: MEKK4)
 Explore 4 diseases affiliated with
MAP3K4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP3K4    

Aliases
for MAP3K4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 41 2     MEKK 42 3
MAPKKK41 2 3 5     PRO04122
MEKK41 2 3 5     DJ473J16.1 (Mitogen-Activated Protein Kinase Kinase Kinase 4)2
MTK11 2 3 5     MAP/ERK Kinase Kinase 42
KIAA02131 3     Predicted Protein Of HQ04122
MAP Three Kinase 12 3     SSK2/SSK22 MAP Kinase Kinase Kinase, Yeast, Homolog Of2
MAPK/ERK Kinase Kinase 42 3     EC 2.7.11.253
MEK Kinase 42 3     

External Ids:    HGNC: 68561   Entrez Gene: 42162   Ensembl: ENSG000000855117   OMIM: 6024255   UniProtKB: Q9Y6R43   

Export aliases for MAP3K4 gene to outside databases

Previous GC identifers: GC06P160766 GC06P161286 GC06P161322 GC06P161383 GC06P161332 GC06P158868


Summaries
for MAP3K4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAP3K4:
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases:
an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then
activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are
activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors.
This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic
domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in
mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated
that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and
JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of
environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two
alternatively spliced transcripts encoding distinct isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: M3K4_HUMAN, Q9Y6R4
Function: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways,
but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6

Gene Wiki entry for MAP3K4


Genomic Views
for MAP3K4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K4 gene promoter:
         Egr-3   Spz1   NRSF form 1   MyoD   AP-4   NRSF form 2   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAP3K4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP3K4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q26   Ensembl cytogenetic band:  6q26   HGNC cytogenetic band: 6q26

MAP3K4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P161412:  view genomic region     (about GC identifiers)

Start:
 161,412,759 bp from pter      End:
 161,538,417 bp from pter
Size:
 125,659 bases      Orientation:
 plus strand

Proteins
for MAP3K4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: M3K4_HUMAN, Q9Y6R4 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 4  
Size: 1608 amino acids; 181685 Da
Cofactor: Magnesium
Subunit: Monomer and homodimer. Homodimerization enhances kinase activity. Interacts with TRAF4; this promotes
homodimerization (By similarity). Binds both upstream activators and downstream substrates in multimolecular
complexes. Interacts with AXIN1 and DIXDC1; interaction with DIXDC1 prevents interaction with AXIN1
Subcellular location: Cytoplasm, perinuclear region (By similarity). Note=Localized in perinuclear vesicular-like
structures, probably Golgi-associated vesicles (By similarity)
Sequence caution: Sequence=BAA13204.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAC12766.2; Type=Erroneous gene model prediction; Sequence=CAH70639.1; Type=Erroneous gene model prediction;
Sequence=CAH70640.1; Type=Erroneous gene model prediction; Sequence=CAI20815.1; Type=Erroneous gene model prediction;
Sequence=CAI20816.1; Type=Erroneous gene model prediction; Sequence=CAI21477.1; Type=Erroneous gene model prediction;
Sequence=CAI41309.1; Type=Erroneous gene model prediction; Sequence=CAI41310.1; Type=Erroneous gene model prediction;
Secondary accessions: A6H8W0 B7ZLD3 B9EG75 Q5VTT8 Q5VTT9 Q92612 Q9H408
Alternative splicing: 2 isoforms:  Q9Y6R4-1   Q9Y6R4-2   

Explore the universe of human proteins at neXtProt for MAP3K4: NX_Q9Y6R4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y6R4

    • MAP3K4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_005913.2  NP_006715.2  

    ENSEMBL proteins: 
     ENSP00000355886   ENSP00000439377   ENSP00000375986   ENSP00000355887   ENSP00000297332  
     ENSP00000445018   ENSP00000446303   ENSP00000390508  

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    OriGene Protein Over-expression Lysate: MAP3K4
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    Novus Biologicals MAP3K4 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAP3K4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0048471perinuclear region of cytoplasm IEA--


    MAP3K4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MAP3K4

    Protein Domains /
    Families
    for MAP3K4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP3K4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6R4

    ProtoNet protein and cluster: Q9Y6R4

    UniProtKB/Swiss-Prot: M3K4_HUMAN, Q9Y6R4
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAP3K4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: M3K4_HUMAN, Q9Y6R4
    Function: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways,
    but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: N-terminal autoinhibitory domain interacts with the C-terminal kinase domain, inhibiting kinase
    activity, and preventing interaction with its substrate, MAP2K6. The GADD45 proteins activate the kinase by binding to
    the N-terminal domain. Activated by phosphorylation on Thr-1505

         Genatlas biochemistry entry for MAP3K4:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 4,major mediator of environnemtal stress,activating the MAPK
    and JNK signal transduction pathway (see MAP4K4)

    Enzyme Number (IUBMB): EC 2.7.11.251

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K4
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K4 (see all 21):
    hsa-miR-148b hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-15a hsa-miR-3129-5p hsa-miR-144 hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmid: MAP3K4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K4 (see all 6)
    OriGene siRNA: MAP3K4
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ISS--
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004709MAP kinase kinase kinase activity IEA--
    GO:0005515protein binding IPI16157600
    GO:0005524ATP binding IEA--


    MAP3K4 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for MAP3K4:
     Decreased telomerase activity  Decreased viability  Increased apoptosis  Increased cell death in DLD-1  

    Animal Models:
         Mouse knock-out Map3k4tm1Flv for MAP3K4
         10 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Map3k4):
     embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  nervous system  reproductive system  skeleton 

    MAP3K4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAP3K4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/43 super-pathways (see all 43) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_A2B receptor- action via G-protein alpha s
    		Development A2B receptor: action via G-protein alpha s1.00
    		Development_A2A receptor signaling0.43
    		Development_A2B receptor- action via G-protein alpha s1.00
    		Development A2A receptor signaling0.43
    2Signal transduction_JNK pathway
    		Signal transduction_JNK pathway1.00
    		Signal transduction JNK pathway0.98
    3Development_TGF-beta receptor signaling
    		Development_TGF-beta receptor signaling1.00
    		Development TGF-beta receptor signaling0.96
    4Immune response_IFN gamma signaling pathway
    		Immune response_IFN gamma signaling pathway1.00
    		Immune response IFN gamma signaling pathway1.00
    5Immune response IL-12-induced IFN-gamma production
    		Immune response IL-12-induced IFN-gamma production1.00
    		Immune response_IL-12-induced IFN-gamma production0.88

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/13 EMD Millipore Pathways for MAP3K4 (see all 13)
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Development Beta-adrenergic receptors signaling via cAMP
    Development A1 receptor signaling
    Development A2A receptor signaling
    Development TGF-beta receptor signaling

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K4 (see all 33)
        Antioxidant Action of Vitamin-C
    Interferon Pathway
    TRKA Signaling
    JNK Pathway
    PACAP Signaling

    5/13 GeneGo (Thomson Reuters) Pathways for MAP3K4 (see all 13)
        Development A2A receptor signaling
    Development Beta-adrenergic receptors signaling via cAMP
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response IL-12-induced IFN-gamma production

    5/9 BioSystems Pathways for MAP3K4 (see all 9) 
        EGFR1 Signaling Pathway
    DNA damage response (only ATM dependent)
    G13 Signaling Pathway
    MAPK signaling pathway
    Integrated Pancreatic Cancer Pathway


    2         Kegg Pathways  (Kegg details for MAP3K4):
        MAPK signaling pathway
    GnRH signaling pathway


    MAP3K4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/108 Interacting proteins for MAP3K4 (Q9Y6R42, 3 ENSP000003759864) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3KBP1Q96B972, 3, ENSP000003809214MINT-7186852 MINT-7186967 MINT-7187506 MINT-7186667 MINT-7187190 I2D: score=2 STRING: ENSP00000380921
    PTK2BQ142892, 3, ENSP000003328164MINT-51385 MINT-51384 I2D: score=3 STRING: ENSP00000332816
    FLNBO753692, 3, ENSP000002959564MINT-7288768 MINT-7288733 I2D: score=1 STRING: ENSP00000295956
    ANXA2P073552, 3, ENSP000003460324MINT-51382 I2D: score=3 STRING: ENSP00000346032
    UBCP0CG482, 3, ENSP000003448184MINT-7186585 MINT-7187359 I2D: score=3 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity TAS9305639
    GO:0001890placenta development IEA--
    GO:0006468protein phosphorylation ----
    GO:0006950response to stress TAS9305639
    GO:0007243intracellular protein kinase cascade ISS--


    MAP3K4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP3K4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP3K4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MAP3K4

    3 HMDB Compounds for MAP3K4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    1 Novoseek chemical compound relationship for MAP3K4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 0 5 15601262 (4)

    Search CenterWatch for drugs/clinical trials and news about MAP3K4 / M3K4 

    Transcripts
    for MAP3K4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP3K4 gene (2 alternative transcripts): 
    NM_005922.2  NM_006724.2  

    Unigene Cluster for MAP3K4:

    Mitogen-activated protein kinase kinase kinase 4
    Hs.390428  [show with all ESTs]
    Unigene Representative Sequence: NM_005922
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366919(uc003qto.3 uc003qtp.3) ENST00000542952 ENST00000392142(uc010kkc.1 uc003qtn.3 uc011efz.2 uc011ega.2)
    ENST00000366920 ENST00000348824 ENST00000544041 ENST00000490904 ENST00000448119
    ENST00000446500 ENST00000542851 ENST00000540205 ENST00000543421 ENST00000541901
    ENST00000544733 ENST00000536852(uc003qtq.3) ENST00000539610

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    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K4

    Additional cDNA sequence: 

    AF002715.1 AF116604.1 AK124430.1 AK307866.1 BC136276.1 BC143735.1 BC143743.1 BC143750.1 
    BC146770.1 D86968.2 

    13 DOTS entries:

    DT.450615  DT.100813358  DT.95329707  DT.100540  DT.114201  DT.435317  DT.95137335  DT.95103363 
    DT.95296284  DT.100674662  DT.121372195  DT.75111096  DT.95312405 

    24/125 AceView cDNA sequences (see all 125):

    AI215795 BM817868 CD699696 BM719813 BM703670 AI051200 AI336266 BQ049757 
    AA317854 AI055806 BQ228725 AW418798 BX503009 AI566955 NM_005922 AA402447 
    BU730102 BQ687209 AF116604 AW029330 CD358176 AF002715 BQ446855 BM474104 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K4 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^
    SP1:                                                                                                  -     -           -     -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                        -           -     -                                 
    SP4:                                                                                                                          -                                 
    SP5:                    -                                                                                                                                       

    ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:        -     -                                 
    SP2:        -     -                                 
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for MAP3K4

    Expression
    for MAP3K4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAAGTGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MAP3K4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K4

    SOURCE GeneReport for Unigene cluster: Hs.390428

    UniProtKB/Swiss-Prot: M3K4_HUMAN, Q9Y6R4
    Tissue specificity: Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in
    other tissues

        SABiosciences Expression via Pathway-Focused PCR Array including MAP3K4: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    In Situ
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    Orthologs
    for MAP3K4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAP3K4 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAP3K41 mitogen-activated protein kinase kinase kinase 4 80.91(n)
    86.56(a)    		   421579  XM_419617.3  XP_419617.2 
    lizard
    (Anolis carolinensis)    		 Reptilia MAP3K46
    		 --
    		 84(a)
    		 1 ↔ 1
    		 1(211667840-211717071)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.158632 Xenopus laevis transcribed sequence with strong similarity more 79.65(n)    CB208399.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii map3k41 mitogen activated protein kinase kinase kinase 4 67.51(n)
    74.32(a)    		   325488  XM_684744.5  XP_689836.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mekk11 , 3 protein amino acid phosphorylation receptor
    signaling more3
    CG7717-PB1    		 50(a)3
    44.34(n)1
    35.6(a)1    		   91C53
    422531  NM_169833.11  NP_732373.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea mtk-13   -- 36(a)   I(5803701-5809423)   --


    ENSEMBL Gene Tree for MAP3K4 (if available)
    TreeFam Gene Tree for MAP3K4 (if available) 

    Paralogs
    for MAP3K4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MAP3K4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2302 NCBI SNPs in MAP3K4 are shown (see all 2302)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1121573571,2
    		C,F--158966912(+) AGAGCC/TAGGGC 1 -- int13Minor allele frequency- T:0.50NA WA 6
    rs1450467071,2
    		--161410840(+) TTACTA/GAGTTC 2 -- us2k10--------
    rs1863631351,2
    		--161410853(+) CTAACA/GCCATG 2 -- us2k10--------
    rs1911518561,2
    		--161410871(+) CCAGAA/GACATT 2 -- us2k10--------
    rs6105381,2
    		C,F,A,H,--161410911(+) AGAACG/AGCTTC 2 -- us2k111Minor allele frequency- A:0.33NA WA CSA EA 373
    rs6106381,2
    		C,F,A,H,--161410978(+) TGAGGC/AGCTCA 2 -- us2k111Minor allele frequency- A:0.50NA WA CSA EA 373
    rs1807299691,2
    		--161411056(+) TTTCCG/TGGACC 2 -- us2k10--------
    rs1865787781,2
    		--161411068(+) AGCATC/GGGGGT 2 -- us2k10--------
    rs1910295821,2
    		--161411087(+) AAGTCA/CCAACA 2 -- us2k10--------
    rs1388348381,2
    		--161411097(+) ACTTAC/TATTGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP3K4 (161412759 - 161538417 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for MAP3K4
         1 CNV: 5227
         3 Indels: 28148 47038 42923

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    Disorders / Diseases
    for MAP3K4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP3K4 for disorders           About GeneDecksing

    OMIM gene information: 602425    OMIM disorders: --

    4 diseases for MAP3K4:    About MalaCards
    breast-ovarian cancer    rheumatoid arthritis    ovarian cancer    arthritis

    1 disease from the University of Copenhagen DISEASES database for MAP3K4:
    Nicotine dependence

    1 Novoseek disease relationship for MAP3K4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 15.7 1 9305639 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAP3K4 (1 document)

    Export disorders for MAP3K4 gene to outside databases

    Publications
    for MAP3K4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K4 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with MAP3K4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. (PubMed id 9305639)1, 2, 3, 9 Takekawa M.... Saito H. (1997)
    2. MEKK4 is an effector of the embryonic TRAF4 for JNK activation. (PubMed id 16157600)1, 2, 9 Abell A.N. and Johnson G.L. (2005)
    3. The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. (PubMed id 15262978)1, 2, 9 Wong C.K.... Lin S.-C. (2004)
    4. Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding. (PubMed id 12052864)1, 2 Mita H.... Saito H. (2002)
    5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    6. Interferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes. (PubMed id 15601262)1, 9 Halfter U.M....Vaillancourt R.R. (2005)
    7. CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway. (PubMed id 16256071)1, 9 Aissouni Y.... Soubeyran P. (2005)
    8. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. (PubMed id 9827804)1, 9 Takekawa M. and Saito H. (1998)
    9. Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. (PubMed id 20221403)1, 9 Kedar V.P....Blackshear P.J. (2010)
    10. Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases. (PubMed id 15866172)1, 9 Takekawa M....Saito H. (2005)

    External Searches for MAP3K4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAP3K4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4216 HGNC: 6856 AceView: MAP3K4 Ensembl:ENSG00000085511 euGenes: HUgn4216
    ECgene: MAP3K4 Kegg: 4216 H-InvDB: MAP3K4

    Other Databases showing MAP3K4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0213

    Specialized Databases showing MAP3K4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP3K4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAP3K4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP3K4 gene:
    Search GeneIP for patents involving MAP3K4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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