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Aliases for MAP3K3 Gene

Aliases for MAP3K3 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 3 2 3 5
  • MAPK/ERK Kinase Kinase 3 2 3 4
  • MAP/ERK Kinase Kinase 3 2 3
  • MEK Kinase 3 3 4
  • MAPKKK3 3 4
  • MEKK 3 3 4
  • MEKK3 3 4
  • EC 2.7.11.25 4

External Ids for MAP3K3 Gene

Previous HGNC Symbols for MAP3K3 Gene

  • MEKK3

Previous GeneCards Identifiers for MAP3K3 Gene

  • GC17P061350
  • GC17P064126
  • GC17P062040
  • GC17P062173
  • GC17P059053
  • GC17P061699
  • GC17P057077

Summaries for MAP3K3 Gene

Entrez Gene Summary for MAP3K3 Gene

  • This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K3 Gene

MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Immune System. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K19.

UniProtKB/Swiss-Prot for MAP3K3 Gene

  • Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.

Gene Wiki entry for MAP3K3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K3 Gene

Genomics for MAP3K3 Gene

Regulatory Elements for MAP3K3 Gene

Promoters for MAP3K3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAP3K3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP3K3 Gene

Chromosome:
17
Start:
63,622,209 bp from pter
End:
63,696,310 bp from pter
Size:
74,102 bases
Orientation:
Plus strand

Genomic View for MAP3K3 Gene

Genes around MAP3K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K3 Gene

Proteins for MAP3K3 Gene

  • Protein details for MAP3K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99759-M3K3_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 3
    Protein Accession:
    Q99759
    Secondary Accessions:
    • B2RCW2
    • D3DU15
    • Q5BKZ6
    • Q8N3I9

    Protein attributes for MAP3K3 Gene

    Size:
    626 amino acids
    Molecular mass:
    70898 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex with MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9.

    Three dimensional structures from OCA and Proteopedia for MAP3K3 Gene

    Alternative splice isoforms for MAP3K3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K3 Gene

Proteomics data for MAP3K3 Gene at MOPED

Post-translational modifications for MAP3K3 Gene

  • Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP3K3 (MEKK3)

No data available for DME Specific Peptides for MAP3K3 Gene

Domains & Families for MAP3K3 Gene

Protein Domains for MAP3K3 Gene

Suggested Antigen Peptide Sequences for MAP3K3 Gene

Graphical View of Domain Structure for InterPro Entry

Q99759

UniProtKB/Swiss-Prot:

M3K3_HUMAN :
  • Contains 1 PB1 domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Domain:
  • Contains 1 PB1 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K3: view

Function for MAP3K3 Gene

Molecular function for MAP3K3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-530.
UniProtKB/Swiss-Prot Function:
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.

Enzyme Numbers (IUBMB) for MAP3K3 Gene

Gene Ontology (GO) - Molecular Function for MAP3K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,IDA 15001576
genes like me logo Genes that share ontologies with MAP3K3: view
genes like me logo Genes that share phenotypes with MAP3K3: view

Animal Models for MAP3K3 Gene

MGI Knock Outs for MAP3K3:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K3 Gene

Localization for MAP3K3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP3K3 Gene COMPARTMENTS Subcellular localization image for MAP3K3 gene
Compartment Confidence
cytosol 5
nucleus 4

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAP3K3 Gene

Pathways & Interactions for MAP3K3 Gene

genes like me logo Genes that share pathways with MAP3K3: view

SIGNOR curated interactions for MAP3K3 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP3K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS 9006902
GO:0001568 blood vessel development IEA --
GO:0006468 protein phosphorylation IEA --
GO:0031098 stress-activated protein kinase signaling cascade IBA --
GO:0035556 intracellular signal transduction IDA 15001576
genes like me logo Genes that share ontologies with MAP3K3: view

Drugs & Compounds for MAP3K3 Gene

(4) Drugs for MAP3K3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(2) Additional Compounds for MAP3K3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAP3K3: view

Transcripts for MAP3K3 Gene

Unigene Clusters for MAP3K3 Gene

Mitogen-activated protein kinase kinase kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for MAP3K3 Gene

GeneLoc Exon Structure for
MAP3K3
ECgene alternative splicing isoforms for
MAP3K3

Expression for MAP3K3 Gene

mRNA expression in normal human tissues for MAP3K3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K3 Gene

This gene is overexpressed in Whole Blood (x6.3).

Protein differential expression in normal tissues from HIPED for MAP3K3 Gene

This gene is overexpressed in Cervix (38.1) and Adipocyte (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP3K3 Gene



SOURCE GeneReport for Unigene cluster for MAP3K3 Gene Hs.29282

genes like me logo Genes that share expression patterns with MAP3K3: view

Protein tissue co-expression partners for MAP3K3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MAP3K3 Gene

Orthologs for MAP3K3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP3K3 35
  • 92.69 (n)
  • 97.26 (a)
MAP3K3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP3K3 35
  • 93.08 (n)
  • 97.6 (a)
MAP3K3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map3k3 35
  • 90.52 (n)
  • 96.65 (a)
Map3k3 16
Map3k3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAP3K3 35
  • 99.8 (n)
  • 99.85 (a)
MAP3K3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map3k3 35
  • 89.88 (n)
  • 96.33 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP3K3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K3 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP3K3 35
  • 80.24 (n)
  • 88.33 (a)
MAP3K3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP3K3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k3 35
  • 72.57 (n)
  • 80.52 (a)
zebrafish
(Danio rerio)
Actinopterygii map3k3 35
  • 71.36 (n)
  • 78.96 (a)
map3k3 36
  • 78 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mtk-1 37
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 36
  • 24 (a)
OneToMany
STE11 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for MAP3K3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP3K3 Gene

ENSEMBL:
Gene Tree for MAP3K3 (if available)
TreeFam:
Gene Tree for MAP3K3 (if available)

Paralogs for MAP3K3 Gene

Paralogs for MAP3K3 Gene

genes like me logo Genes that share paralogs with MAP3K3: view

Variants for MAP3K3 Gene

Sequence variations from dbSNP and Humsavar for MAP3K3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_037275 -
VAR_037276 -
VAR_040685 -
rs15637 -- 63,694,690(-) GCCCC(C/G)ACCGT utr-variant-3-prime
rs1060465 -- 63,681,232(-) TGTAT(C/T)AGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K3 Gene

Variant ID Type Subtype PubMed ID
esv2510594 CNV Insertion 19546169
esv271856 CNV Insertion 20981092
esv2671505 CNV Deletion 23128226

Variation tolerance for MAP3K3 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K3 Gene

HapMap Linkage Disequilibrium report
MAP3K3
Human Gene Mutation Database (HGMD)
MAP3K3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K3 Gene

Disorders for MAP3K3 Gene

Relevant External Links for MAP3K3

Genetic Association Database (GAD)
MAP3K3
Human Genome Epidemiology (HuGE) Navigator
MAP3K3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K3

No disorders were found for MAP3K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K3 Gene

Publications for MAP3K3 Gene

  1. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase/ERK kinase kinase 3 (MEKK) derivative. (PMID: 9006902) Ellinger-Ziegelbauer H.C. … Siebenlist U. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. (PMID: 19903815) Nakamura K. … Johnson G.L. (J. Biol. Chem. 2010) 3 23
  3. Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic acid-mediated optimal IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-kappaB) activation. (PMID: 20068038) Sun W. … Yang J. (J. Biol. Chem. 2010) 3 23
  4. Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling. (PMID: 19843958) Yamazaki K. … Inoue J. (Sci Signal 2009) 3 23
  5. Phosphorylation of MEKK3 at threonine 294 promotes 14-3-3 association to inhibit nuclear factor kappaB activation. (PMID: 18308725) Matitau A.E. … Scheid M.P. (J. Biol. Chem. 2008) 3 23

Products for MAP3K3 Gene

Sources for MAP3K3 Gene

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