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MAP3K3 Gene

protein-coding   GIFtS: 71
GCID: GC17P061699

Mitogen-Activated Protein Kinase Kinase Kinase 3


(Previous symbol: MEKK3)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 31 2     MAPKKK32 3
MEKK31 2 3     MEK Kinase 32 3
MAPK/ERK Kinase Kinase 31 2 3     MEKK 32 3
MAP/ERK Kinase Kinase 31 2     EC 2.7.11.253

External Ids:    HGNC: 68551   Entrez Gene: 42152   Ensembl: ENSG000001989097   OMIM: 6025395   UniProtKB: Q997593   

Export aliases for MAP3K3 gene to outside databases

Previous GC identifers: GC17P061350 GC17P064126 GC17P062040 GC17P062173 GC17P059053 GC17P057077


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP3K3 Gene:
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is
closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern
blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly
regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK)
pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection
assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a
role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been
observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP3K3 Gene:
MAP3K3 (mitogen-activated protein kinase kinase kinase 3) is a protein-coding gene. Diseases associated with MAP3K3 include cerebral cavernous malformations-2, and cavernous malformation. GO annotations related to this gene include MAP kinase kinase kinase activity and protein kinase activity. An important paralog of this gene is MAP3K1.

UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759
Function: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1
and DDIT3 transcriptional regulators

Gene Wiki entry for MAP3K3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP3K3 gene promoter:
         AhR   GATA-6   POU2F1   AP-1   POU2F1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP3K3 promoter sequence
   Search Chromatin IP Primers for MAP3K3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP3K3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q

MAP3K3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P061699:  view genomic region     (about GC identifiers)

Start:
61,699,775 bp from pter      End:
61,773,670 bp from pter
Size:
73,896 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 3  
Size: 626 amino acids; 70898 Da
Cofactor: Magnesium
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex
with MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9
4 PDB 3D structures from and Proteopedia for MAP3K3:
2C60 (3D)        2JRH (3D)        2O2V (3D)        2PPH (3D)    
Secondary accessions: B2RCW2 D3DU15 Q5BKZ6 Q8N3I9
Alternative splicing: 2 isoforms:  Q99759-1   Q99759-2   

Explore the universe of human proteins at neXtProt for MAP3K3: NX_Q99759

Explore proteomics data for MAP3K3 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAP3K3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002392.2  NP_976226.1  

    ENSEMBL proteins: 
     ENSP00000461988   ENSP00000464130   ENSP00000354485   ENSP00000354927   ENSP00000462086  
     ENSP00000462917   ENSP00000464532   ENSP00000464482  
    Reactome Protein details: Q99759

    MAP3K3 Human Recombinant Protein Products:

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    Novus Biologicals MAP3K3 Proteins
    Novus Biologicals MAP3K3 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP3K3

    MAP3K3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP3K3
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    Cell Signaling Technology (CST) Antibodies for MAP3K3  (MEKK3)
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    Novus Biologicals MAP3K3 Antibodies
    Abcam antibodies for MAP3K3
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    MAP3K3 Assay Products:

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    Cloud-Clone Corp. ELISAs for MAP3K3
    Cloud-Clone Corp. CLIAs for MAP3K3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 3
    STE11 family

    4 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR000270 OPR_PB1

    Graphical View of Domain Structure for InterPro Entry Q99759

    ProtoNet protein and cluster: Q99759

    1 Blocks protein domain: IPB000270 Octicosapeptide/Phox/Bem1p

    UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 protein kinase domain


    MAP3K3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K3_HUMAN, Q99759
    Function: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1
    and DDIT3 transcriptional regulators
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-530 (By similarity)

         Enzyme Number (IUBMB): EC 2.7.11.251

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA15001576
    GO:0004709MAP kinase kinase kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12392720
    GO:0005524ATP binding IEA--
         
    MAP3K3 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAP3K3:
     Decreased mitotic index  Decreased substrate adherent c  Decreased telomerase activity  Increased cell death HMECs cel 
     Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Map3k3):
     cardiovascular system  craniofacial  embryogenesis  hematopoietic system  immune system 
     mortality/aging  muscle 

    MAP3K3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP3K3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP3K3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP3K3

    miRNA
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    miRTarBase miRNAs that target MAP3K3:
    hsa-mir-124-3p (MIRT023113), hsa-mir-193b-3p (MIRT041562), hsa-mir-9-5p (MIRT021476), hsa-mir-132-3p (MIRT021851)

    Block miRNA regulation of human, mouse, rat MAP3K3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP3K3 (see all 119):
    hsa-miR-323-3p hsa-miR-193a-3p hsa-miR-1321 hsa-miR-188-5p hsa-miR-106a hsa-miR-200a hsa-miR-519a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAP3K3
    Predesigned siRNA for gene silencing in human, mouse, rat MAP3K3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): MAP3K3 (NM_002401)
    Sino Biological Human cDNA Clone for MAP3K3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    MAP3K3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP3K3 About   (see all 42)  
    See pathways by source

    SuperPathContained pathways About
    1Interleukin-1 signaling
    Interleukin-1 signaling0.45
    IL1-mediated signaling events0.45
    2NGF Pathway
    TRKA Signaling0.75
    NGF Pathway0.75
    3NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72
    4TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    TCR Signaling0.68
    5Integrin Pathway
    Integrin Pathway0.67
    GnRH Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP3K3 (see all 34)
        Toll-Like Receptors Pathway
    Antioxidant Action of Vitamin-C
    Interferon Pathway
    TRKA Signaling
    ERK5 Signaling

    1 Cell Signaling Technology (CST) Pathway for MAP3K3
        MAP Kinase Signaling

    3 GeneGo (Thomson Reuters) Pathways for MAP3K3
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction JNK pathway
    Immune response Function of MEF2 in T lymphocytes

    Selected BioSystems Pathways for MAP3K3 (see all 9)
        EBV LMP1 signaling
    EGFR1 Signaling Pathway
    Insulin Signaling
    MAPK Cascade
    TNF-alpha/NF-kB Signaling Pathway


    1 Reactome Pathway for MAP3K3
        Interleukin-1 signaling


    4 Kegg Pathways  (Kegg details for MAP3K3):
        MAPK signaling pathway
    Neurotrophin signaling pathway
    GnRH signaling pathway
    HTLV-I infection


    MAP3K3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MAP3K3: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP3K3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP3K3 (Q997591, 2, 3 ENSP000003549274) via UniProtKB, MINT, STRING, and/or I2D (see all 367)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3MINT-48494 I2D: score=2 
    HIST1H4BP628052, 3MINT-48494 I2D: score=2 
    HIST1H4CP628052, 3MINT-48494 I2D: score=2 
    HIST1H4DP628052, 3MINT-48494 I2D: score=2 
    HIST1H4EP628052, 3MINT-48494 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS9006902
    GO:0000186activation of MAPKK activity TAS9006902
    GO:0006468protein phosphorylation ----
    GO:0035556intracellular signal transduction IDA15001576
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IEP12761501

    MAP3K3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    4 ApexBio Compounds for MAP3K3     About this table
    CompoundAction CAS #
    FR 180204Selective ERK inhibitor[865362-74-9]
    VX-11epotent, selective, and orally bioavailable inhibitor of ERK[896720-20-0]
    XMD17-109novel, specific ERK-5 inhibitor with an EC50 4.2uM in HEK293 cells[1435488-37-1]
    XMD8-92highly selective ERK5/BMK1 inhibitor[1234480-50-2]

    Browse Tocris compounds for MAP3K3 (M3K3)

    3 HMDB Compounds for MAP3K3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    3 Novoseek inferred chemical compound relationships for MAP3K3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 42.9 2 11343802 (2)
    arsenite 34.4 1 10618720 (1)
    serine 16.7 7 11343802 (4), 12392720 (1), 16362041 (1)



    MAP3K3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAP3K3 gene (2 alternative transcripts): 
    NM_002401.3  NM_203351.1  

    Unigene Cluster for MAP3K3:

    Mitogen-activated protein kinase kinase kinase 3
    Hs.29282  [show with all ESTs]
    Unigene Representative Sequence: NM_203351
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000579585 ENST00000584573 ENST00000361733 ENST00000361357(uc002jbe.3 uc002jbf.3 uc002jbg.3 uc002jbh.3 uc010wpo.2 uc010wpp.2)
    ENST00000577395 ENST00000577597 ENST00000585302 ENST00000578622 ENST00000577784
    ENST00000577839 ENST00000581732
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate MAP3K3 (see all 119):
    hsa-miR-323-3p hsa-miR-193a-3p hsa-miR-1321 hsa-miR-188-5p hsa-miR-106a hsa-miR-200a hsa-miR-519a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): MAP3K3 (NM_002401)
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      QuantiTect SYBR Green Assays in human, mouse, rat MAP3K3
      QuantiFast Probe-based Assays in human, mouse, rat MAP3K3

    Additional mRNA sequence: 

    AF172823.1 AK225784.1 AK308152.1 AK315305.1 AL834303.1 BC008336.1 BC010464.1 BC018021.1 
    BC090859.1 BC093672.1 BC093674.1 BC143224.1 BC143235.1 DQ454151.1 U78876.1 

    10 DOTS entries:

    DT.113632  DT.100781709  DT.445173  DT.100707638  DT.102830397  DT.40270938  DT.97864206  DT.100687871 
    DT.100781708  DT.120925588 

    Selected AceView cDNA sequences (see all 208):

    AU141033 AA443920 BM800091 AA995176 AI312609 BQ879345 AL834303 BQ231997 
    BM770779 NM_002401 AX775739 BU729165 NM_203351 BU633068 BC018021 BQ008632 
    BG231756 BU172112 BQ059664 CB306334 AI963407 AI033449 BU188732 AI679545 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                        -                                                                     
    SP2:                                                                                                                              
    SP3:                                                                                                                    -         
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for MAP3K3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAP3K3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAP3K3 Expression
    About this image


    MAP3K3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Ovary (Reproductive System)
     
     Lymph (Hematopoietic System)
    MAP3K3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP3K3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.29282
        Pathway & Disease-focused RT2 Profiler PCR Array including MAP3K3: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP3K3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k31 , 5 mitogen-activated protein kinase kinase kinase 31, 5 90.52(n)1
    96.65(a)1
      11 (68.89 cM)5
    264061  NM_011947.31  NP_036077.11 
     1060846135 
    chicken
    (Gallus gallus)
    Aves MAP3K31 mitogen-activated protein kinase kinase kinase 3 80.24(n)
    88.33(a)
      419954  XM_418076.3  XP_418076.3 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K36
    mitogen-activated protein kinase kinase kinase 3
    85(a)
    1 ↔ 1
    6(60910466-60952613)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia map3k31 mitogen-activated protein kinase kinase kinase 3 72.57(n)
    80.52(a)
      100490021  XM_002935554.2  XP_002935600.2 
    zebrafish
    (Danio rerio)
    Actinopterygii map3k31 mitogen-activated protein kinase kinase kinase 3 71.36(n)
    78.96(a)
      560211  XM_683602.4  XP_688694.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE11(YLR362W)4 Signal transducing MEK kinase involved in pheromone more   --   12(849866-852019) 851076  NP_013466.1 
    rice
    (Oryza sativa)
    Liliopsida AK065413.12   -- 71.12(n)    AK065413.1 


    ENSEMBL Gene Tree for MAP3K3 (if available)
    TreeFam Gene Tree for MAP3K3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP3K3 gene
    MAP3K12  MAP3K52  MAP3K152  MAP3K82  MAP3K22  MAP3K192  MAP3K62  
    Selected SIMAP similar genes for MAP3K3 using alignment to 7 protein entries:     M3K3_HUMAN (see all proteins) (see all similar genes):
    MST094    MAP3K2    MAPK3    STK11    NEK9    STK25
    MARK4    TAOK3    NEK6    DAPK3    PHKG2    MAP4K5
    BRAF    PAK1    PRKCH    RPS6KA1    RPS6KA2    BRSK2

    MAP3K3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP3K3 (see all 1371)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80695531,2
    C,F--61697922(+) ATCCCC/TGCTTT 2 -- us2k13Minor allele frequency- T:0.08CSA WA 122
    rs1496580151,2
    C--61698016(+) TGTTGC/GAAGAA 2 -- us2k10--------
    rs1908313631,2
    --61698057(+) TATACA/GGAGAT 2 -- us2k10--------
    rs1466723331,2
    C--61698103(+) CTCACA/GCCTGT 2 -- us2k10--------
    rs1402774071,2
    --61698221(+) TTAGCC/TGGGCG 2 -- us2k10--------
    rs1453832271,2
    --61698228(+) GGCGTA/GGTGGC 2 -- us2k10--------
    rs1481889911,2
    C--61698381(+) AAAGA-/AAAAG 
            
    AAAAG
    2 -- us2k10--------
    rs1841659051,2
    --61698408(+) GCCCAA/GGGTAA 2 -- us2k10--------
    rs1161790751,2
    C,F--61698564(+) GTGGAC/TTTGGA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs118717671,2
    C,F,H--61698723(+) ATACTA/GCAAAA 2 -- us2k112Minor allele frequency- G:0.26NS EA WA NA CSA 785

    HapMap Linkage Disequilibrium report for MAP3K3 (61699775 - 61773670 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MAP3K3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671505CNV Deletion23128226
    esv2510594CNV Insertion19546169
    esv271856CNV Insertion20981092

    Human Gene Mutation Database (HGMD): MAP3K3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP3K3
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602539    OMIM disorders: --

    13 diseases for MAP3K3:    
    About MalaCards
    cerebral cavernous malformations-2    cavernous malformation    cerebral cavernous malformation    lymphopenia
    protein s deficiency    cerebritis    cervical cancer    cervicitis
    neuroblastoma    rheumatoid arthritis    arthritis    endotheliitis
    hepatocellular carcinoma


    MAP3K3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MAP3K3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 33.8 6 14662759 (1), 17116170 (1), 19843958 (1), 15047705 (1) (see all 6)
    tumors 8.9 7 19517469 (2), 14662759 (1), 19843958 (1), 16260783 (1) (see all 6)
    cancer 0 3 14662759 (2), 19517469 (1)

    Genetic Association Database (GAD): MAP3K3
    Human Genome Epidemiology (HuGE) Navigator: MAP3K3 (3 documents)

    Export disorders for MAP3K3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP3K3 gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with MAP3K3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase/ERK kinase kinase 3 (MEKK) derivative. (PubMed id 9006902)1, 2, 3, 9 Ellinger-Ziegelbauer H.C.... Siebenlist U. (J. Biol. Chem. 1997)
    2. PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway. (PubMed id 12912994)1, 2, 9 Nakamura K. and Johnson G.L. (J. Biol. Chem. 2003)
    3. Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. (PubMed id 14661019)1, 2, 9 Huang Q.... Su B. (Nat. Immunol. 2004)
    4. Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe). (PubMed id 22021425)1, 4 Carty C.L....Kooperberg C. (Hum. Mol. Genet. 2012)
    5. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1, 4 N'Diaye A....Haiman C.A. (PLoS Genet. 2011)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1, 2 Bouwmeester T....Superti-Furga G. (Nat. Cell Biol. 2004)
    10. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. (PubMed id 9162092)1, 9 Deacon K. and Blank J.L. (J. Biol. Chem. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4215 HGNC: 6855 AceView: MAP3K3 Ensembl:ENSG00000198909 euGenes: HUgn4215
    ECgene: MAP3K3 Kegg: 4215 H-InvDB: MAP3K3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP3K3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP3K3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP3K3 gene:
    Search GeneIP for patents involving MAP3K3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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