MAP3K3 Gene
protein-coding GIFtS: 67
GCID: GC17P061699
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|
mitogen-activated protein kinase kinase kinase 3
(Previous symbol: MEKK3)
| |
Aliases
for MAP3K3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitogen-Activated Protein Kinase Kinase Kinase 31 2 | | MEK Kinase 32 3 | | MAPKKK31 2 3 | | MEKK 32 3 | | MEKK31 2 3 | | MAP/ERK Kinase Kinase 32 | | MAPK/ERK Kinase Kinase 32 3 | | EC 2.7.11.253 |
Export aliases for MAP3K3 gene to outside databasesPrevious GC identifers: GC17P061350 GC17P064126 GC17P062040 GC17P062173 GC17P059053 GC17P057077 |
Summaries
for MAP3K3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAP3K3:
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain isclosely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blotanalysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates thestress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activatingSEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcriptionfrom a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway.Alternatively spliced transcript variants encoding distinct isoforms have been observed. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759Function: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 andDDIT3 transcriptional regulators
Gene Wiki entry for MAP3K3
|
Genomic Views
for MAP3K3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP3K3 gene promoter:
AhR GATA-6 POU2F1 AP-1 POU2F1a ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP3K3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23.3 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17qMAP3K3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P061699: view genomic region
(about GC identifiers)
Start:
|
61,699,775 bp from pter |
End:
|
61,773,670 bp from pter |
Size:
|
73,896 bases |
Orientation:
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plus strand |
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Proteins
for MAP3K3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759 (See
protein sequence)Recommended Name: Mitogen-activated protein kinase kinase kinase 3 Size: 626 amino acids; 70898 Da
Cofactor: Magnesium
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex withMAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9
4 PDB 3D structures from  and Proteopedia  for MAP3K3:2C60 (3D)
2JRH (3D)
2O2V (3D)
2PPH (3D)
Secondary accessions: B2RCW2 D3DU15 Q5BKZ6 Q8N3I9Alternative splicing: 2 isoforms: Q99759-1 Q99759-2 Explore the universe of human proteins at neXtProt for MAP3K3: NX_Q99759
Post-translational modifications:
Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99759
MAP3K3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_002392.2 NP_976226.1
ENSEMBL proteins: ENSP00000461988 ENSP00000464130 ENSP00000354485 ENSP00000354927 ENSP00000462086 ENSP00000462917 ENSP00000464532 ENSP00000464482 Reactome Protein details: Q99759
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
MAP3K3 for ontologies About GeneDecksing
MAP3K3 Antibody Products:
Assay Products for MAP3K3: |
Protein
Domains /
Families
for MAP3K3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP3K3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99759ProtoNet protein and cluster: Q99759 1 Blocks protein family: IPB000270 Octicosapeptide/Phox/Bem1p
UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinasesubfamilySimilarity: Contains 1 OPR domainSimilarity: Contains 1 protein kinase domain |
Function
for MAP3K3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759Function: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 andDDIT3 transcriptional regulatorsCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by phosphorylation on Thr-530 (By similarity)Enzyme Number (IUBMB): EC 2.7.11.251
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MAP3K3 (NM_002401) | |  | Sino Biological Human cDNA Clone for MAP3K3 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP3K3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K3 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
MAP3K3 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for MAP3K3:
Animal Models:
8 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Map3k3):
MAP3K3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAP3K3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/44 super-pathways (see all 44) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response_Function of MEF2 in T lymphocytes | | | 2 | Signal transduction_JNK pathway | | | 3 | Interleukin-1 signaling | | | 4 | Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis | | | 5 | TRKA Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for MAP3K3
5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K3 (see all 34)
1 
Cell Signaling Technology (CST) Pathway for MAP3K3
3  GeneGo (Thomson Reuters) Pathways for MAP3K3
5/9  BioSystems Pathways for MAP3K3 (see all 9)
4 
Reactome Pathways for MAP3K3
3 
Kegg Pathways (Kegg details for MAP3K3):
MAP3K3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/238 Interacting proteins for MAP3K3 (Q997591, 2, 3 ENSP000003549274) via UniProtKB, MINT, STRING, and/or I2D (see all 238)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
MAP3K3 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAP3K3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MAP3K3 for compounds About GeneDecksing
 Browse Tocris compounds for MAP3K3
3 HMDB Compounds for MAP3K3 About this table
3 Novoseek chemical compound relationships for MAP3K3 gene About this table
Search CenterWatch for drugs/clinical trials and news about MAP3K3 / M3K3
|
Transcripts
for MAP3K3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAP3K3 gene (2 alternative transcripts): NM_002401.3 NM_203351.1 Unigene Cluster for MAP3K3: Mitogen-activated protein kinase kinase kinase 3 Hs.29282 [show with all ESTs]Unigene Representative Sequence: NM_20335111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000579585 ENST00000584573 ENST00000361733 ENST00000361357(uc002jbe.3 uc002jbf.3 uc002jbg.3 uc002jbh.3 uc010wpo.2 uc010wpp.2)
ENST00000577395 ENST00000577597 ENST00000585302 ENST00000578622 ENST00000577784
ENST00000577839 ENST00000581732
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MAP3K3 (NM_002401) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP3K3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K3 |
Additional cDNA sequence: AF172823.1 AK225784.1 AK308152.1 AK315305.1 AL834303.1 BC008336.1 BC010464.1 BC018021.1 BC090859.1 BC093672.1 BC093674.1 BC143224.1 BC143235.1 DQ454151.1 U78876.1 10 DOTS entries: DT.113632 DT.100781709 DT.445173 DT.100707638 DT.102830397 DT.40270938 DT.97864206 DT.100687871 DT.100781708 DT.120925588 24/208 AceView cDNA sequences (see all 208): AL834303 NM_203351 BM800091 AI278243 AI312609 AU141033 BU633068 BU188732 BQ060812 NM_002401 AI033449 BF315349 AA443212 BQ059664 AI679545 BQ008632 BQ879345 AI679984 BQ002723 BQ896921 BC018021 AX775741 AA443920 BM541688
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAP3K3
|
Expression
for MAP3K3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAP3K3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MAP3K3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP3K3
SOURCE GeneReport for Unigene cluster: Hs.29282
SABiosciences Expression via Pathway-Focused PCR Array including MAP3K3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP3K3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP3K3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K3 |
Orthologs
for MAP3K3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MAP3K3 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MAP3K31 |
mitogen-activated protein kinase kinase kinase 3 |
80.18(n)
88.17(a) |
|
419954 XM_418076.2 XP_418076.2 |
lizard
(Anolis carolinensis) |
Reptilia |
MAP3K36 |
-- |
87(a) |
1 ↔ 1 |
6(60910466-60937508) |
zebrafish
(Danio rerio) |
Actinopterygii |
map3k31 |
mitogen-activated protein kinase kinase kinase 3 |
71.36(n)
78.96(a) |
|
560211 XM_683602.3 XP_688694.2 |
rice
(Oryza sativa) |
Liliopsida |
AK065413.12 |
-- |
71.12(n) |
|
AK065413.1 |
ENSEMBL Gene Tree for MAP3K3 (if available)
TreeFam Gene Tree for MAP3K3 (if available) |
Paralogs
for MAP3K3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAP3K3 gene
- MAP3K12 MAP3K52 MAP3K152 MAP3K192 MAP3K22 MAP3K82 MAP3K62
18/48 SIMAP similar genes for MAP3K3 using alignment to 7 protein entries: M3K3_HUMAN (see all proteins)
(see all similar genes):MST094 MAP3K2 MAPK3 STK11 NEK9 STK25
MARK4 TAOK3 NEK6 PHKG2 MAP4K5 BRAF
NEK5 PAK1 PRKCH RPS6KA1 RPS6KA2 BRSK2
MAP3K3 for paralogs About GeneDecksing
|
Genomic Variants
for MAP3K3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAP3K3 (61699775 - 61773670 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAP3K3
1 CNV: 102504 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K3 |
|
Disorders
/ Diseases
for MAP3K3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAP3K3 for disorders About GeneDecksing
OMIM gene information: 602539
OMIM disorders: --
9  diseases for MAP3K3: About MalaCardslymphopenia rheumatoid arthritis protein s deficiency hepatocellular carcinoma
cervical cancer cervicitis arthritis neuroblastoma
carcinoma
3 Novoseek disease relationships for MAP3K3 gene About this table
Human Genome Epidemiology (HuGE) Navigator: MAP3K3 (3 documents)
Export disorders for MAP3K3 gene to outside databases
|
Publications
for MAP3K3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAP3K3 gene, integrated from 9 sources (see all 94):
(articles sorted by number of sources associating them with MAP3K3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase/ERK kinase kinase 3 (MEKK) derivative. (PubMed id 9006902)1, 2, 3, 9 Ellinger-Ziegelbauer H.C.... Siebenlist U. (1997)
- PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway. (PubMed id 12912994)1, 2, 9 Nakamura K. and Johnson G.L. (2003)
- Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. (PubMed id 14661019)1, 2, 9 Huang Q.... Su B. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1, 2 Bouwmeester T....Superti-Furga G. (2004)
- Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. (PubMed id 9162092)1, 9 Deacon K. and Blank J.L. (1997)
- Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB. (PubMed id 14662759)1, 9 Samanta A.K....Liao W.S. (2004)
- Phosphorylation of MEKK3 at threonine 294 promotes 14-3-3 association to inhibit nuclear factor kappaB activation. (PubMed id 18308725)1, 9 Matitau A.E. and Scheid M.P. (2008)
- Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 1. (PubMed id 12761204)2, 9 Chun J....Kang S.S. (2003)
- Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic acid-mediated optimal IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-kappaB) activation. (PubMed id 20068038)1, 9 Sun W....Yang J. (2010)
|
External Searches for MAP3K3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAP3K3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAP3K3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAP3K3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAP3K3 gene:
Search GeneIP for patents involving MAP3K3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAP3K3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for MAP3K3 | | OriGene shRNA RFP for MAP3K3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP3K3 | | | OriGene Protein Over-expression Lysate for MAP3K3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAP3K3 | | OriGene 3'-UTR Clone for MAP3K3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAP3K3 | | OriGene Custom Protein Services for MAP3K3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP3K3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K3 |
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| | Antibodies & Assays for MAP3K3 (MEKK3) |
| | | | Search Tocris compounds for MAP3K3 |
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 | | | MAP3K3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K3 |
|  |  |  | | | | ThermoFisher Antibodies for MAP3K3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K3 |
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