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Aliases for MAP3K21 Gene

Aliases for MAP3K21 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 21 2 3 5
  • Mixed Lineage Kinase 4 2 3 4
  • EC 2.7.11.25 4 61
  • MLK4 3 4
  • Mitogen-Activated Protein Kinase Kinase Kinase MLK4 3
  • DJ862P8.3 3
  • EC 2.7.11 61
  • KIAA1804 4

External Ids for MAP3K21 Gene

Summaries for MAP3K21 Gene

GeneCards Summary for MAP3K21 Gene

MAP3K21 (Mitogen-Activated Protein Kinase Kinase Kinase 21) is a Protein Coding gene. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for MAP3K21 Gene

  • Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K21 Gene

Genomics for MAP3K21 Gene

Regulatory Elements for MAP3K21 Gene

Enhancers for MAP3K21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G233326 1 ENCODE 36 +0.4 419 2.9 PKNOX1 AGO1 ZNF133 SIN3A GLI4 ZNF2 ZNF121 GLIS2 KLF7 SP3 MAP3K21 GC01M233432
GH01G233329 0.7 Ensembl 40.9 +2.4 2358 0.6 ZNF362 ZNF280D ZNF140 ZNF384 ZNF366 ZNF610 ZNF701 ZNF416 PRDM1 ZBTB20 MAP3K21 RPS7P3 GC01M233432
GH01G233288 1.3 Ensembl ENCODE 12.5 -35.3 -35335 7.9 SIN3A FEZF1 YBX1 GLI4 ZNF2 TCF12 GLIS2 GATA2 ZNF302 ZNF143 MAP3K21 PCNX2 RPS7P3
GH01G233366 0.7 ENCODE 22.1 +40.1 40097 2.1 LEF1 KLF1 ZEB1 ZNF316 NFE2 KLF7 MAFK NFE2L2 TCF7L2 SCRT1 MAP3K21 GC01M233432
GH01G233359 0.7 ENCODE 13.3 +31.9 31874 0.4 MAX FEZF1 RAD21 YY1 ZBTB20 ZNF263 ZNF843 FOXA1 OSR2 HNF1A MAP3K21 GC01M233432
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP3K21 on UCSC Golden Path with GeneCards custom track

Promoters for MAP3K21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021988 157 1801 PKNOX1 AGO1 ZNF133 SIN3A GLI4 ZNF2 GLIS2 KLF7 SP3 TSHZ1

Genomic Location for MAP3K21 Gene

Chromosome:
1
Start:
233,327,743 bp from pter
End:
233,385,148 bp from pter
Size:
57,406 bases
Orientation:
Plus strand

Genomic View for MAP3K21 Gene

Genes around MAP3K21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K21 Gene

Proteins for MAP3K21 Gene

  • Protein details for MAP3K21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCX8-M3KL4_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase MLK4
    Protein Accession:
    Q5TCX8
    Secondary Accessions:
    • B2RN34
    • Q5TCX7
    • Q5TCX9
    • Q8WWN1
    • Q8WWN2
    • Q96JM1

    Protein attributes for MAP3K21 Gene

    Size:
    1036 amino acids
    Molecular mass:
    113957 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with TLR4.
    SequenceCaution:
    • Sequence=BAB47433.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP3K21 Gene

    Alternative splice isoforms for MAP3K21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K21 Gene

Selected DME Specific Peptides for MAP3K21 Gene

Q5TCX8:
  • ILHRDLK
  • HRDLKSSN
  • LAVAYGVA
  • LRTKEKELRSREEEL
  • LWELLTGE
  • EARLFAML
  • SGDEGWW
  • WMAPEVI

Post-translational modifications for MAP3K21 Gene

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K21 Gene

Domains & Families for MAP3K21 Gene

Gene Families for MAP3K21 Gene

Suggested Antigen Peptide Sequences for MAP3K21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TCX8

UniProtKB/Swiss-Prot:

M3KL4_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K21: view

Function for MAP3K21 Gene

Molecular function for MAP3K21 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.
UniProtKB/Swiss-Prot Function:
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

Enzyme Numbers (IUBMB) for MAP3K21 Gene

Gene Ontology (GO) - Molecular Function for MAP3K21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004706 JUN kinase kinase kinase activity IBA --
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0004871 signal transducer activity IBA --
genes like me logo Genes that share ontologies with MAP3K21: view
genes like me logo Genes that share phenotypes with MAP3K21: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP3K21 Gene

Localization for MAP3K21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K21 gene
Compartment Confidence
cytosol 4
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MAP3K21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MAP3K21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K21 Gene

Pathways & Interactions for MAP3K21 Gene

SuperPathways for MAP3K21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP3K21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation ISS,IBA --
GO:0007256 activation of JNKK activity IEA --
GO:0007257 activation of JUN kinase activity IBA,ISS --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP3K21: view

No data available for Pathways by source and SIGNOR curated interactions for MAP3K21 Gene

Drugs & Compounds for MAP3K21 Gene

(1) Drugs for MAP3K21 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with MAP3K21: view

Transcripts for MAP3K21 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K21 Gene

No ASD Table

Relevant External Links for MAP3K21 Gene

GeneLoc Exon Structure for
MAP3K21
ECgene alternative splicing isoforms for
MAP3K21

Expression for MAP3K21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Evidence on tissue expression from TISSUES for MAP3K21 Gene

  • Lung(2.3)
genes like me logo Genes that share expression patterns with MAP3K21: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K21 Gene

Orthologs for MAP3K21 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP3K21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469711 34
  • 99 (n)
-- 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 84 (a)
OneToOne
KIAA1804 34
  • 83.32 (n)
cow
(Bos Taurus)
Mammalia LOC616014 34
  • 82.92 (n)
-- 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC021891 34 35
  • 73.98 (n)
Map3k21 16
rat
(Rattus norvegicus)
Mammalia RGD1306091 34
  • 73.75 (n)
chicken
(Gallus gallus)
Aves LOC428586 34
  • 71.43 (n)
-- 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-120p12.3 34 35
  • 63.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta slpr 35
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8999 35
  • 34 (a)
OneToMany
Species where no ortholog for MAP3K21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K21 Gene

ENSEMBL:
Gene Tree for MAP3K21 (if available)
TreeFam:
Gene Tree for MAP3K21 (if available)

Paralogs for MAP3K21 Gene

genes like me logo Genes that share paralogs with MAP3K21: view

Variants for MAP3K21 Gene

Sequence variations from dbSNP and Humsavar for MAP3K21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000020006 -- 233,330,027(+) GCCCT(A/G)GCATT intron-variant
rs1000034979 -- 233,378,147(+) TAGGT(A/G)TACTA intron-variant
rs1000089489 -- 233,336,303(+) TGGGA(A/G)GCTGA intron-variant
rs1000141181 -- 233,327,798(+) GACGT(A/C/T)GCCCG utr-variant-5-prime
rs1000189097 -- 233,385,354(+) TTTTG(A/G)TTTAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MAP3K21 Gene

Variant ID Type Subtype PubMed ID
esv22442 CNV gain 19812545
esv2431778 CNV insertion 19546169
esv3305388 CNV mobile element insertion 20981092
esv3309615 CNV mobile element insertion 20981092
esv3325227 CNV insertion 20981092
esv3325872 CNV insertion 20981092
esv3354604 CNV insertion 20981092
nsv1069391 CNV deletion 25765185
nsv1112566 CNV deletion 24896259
nsv1118149 CNV deletion 24896259

Variation tolerance for MAP3K21 Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.70; 93.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K21 Gene

Disorders for MAP3K21 Gene

Relevant External Links for MAP3K21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K21

No disorders were found for MAP3K21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K21 Gene

Publications for MAP3K21 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. MLK4 has negative effect on TLR4 signaling. (PMID: 21602844) Seit-Nebi A. … Han J. (Cell. Mol. Immunol. 2012) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-I_B-dependent Manner. (PMID: 26859459) Kim S.H. … Nakano I. (Cancer Cell 2016) 3 64
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64

Products for MAP3K21 Gene

Sources for MAP3K21 Gene

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