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Aliases for MAP3K20 Gene

Aliases for MAP3K20 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 20 2 3
  • Mitogen-Activated Protein Kinase Kinase Kinase MLT 3 5
  • MLK-Like Mitogen-Activated Protein Triple Kinase 3 4
  • Human Cervical Cancer Suppressor Gene 4 Protein 3 4
  • Mixed Lineage Kinase 7 2 3
  • HCCS-4 3 4
  • MLTK 3 4
  • MRK 3 4
  • ZAK 3 4
  • ZAK1 Homolog, Leucine Zipper And Sterile-Alpha Motif Kinase (Dictyostelium) 2
  • Mixed Lineage Kinase With A Leucine Zipper And A Sterile Alpha Motif 3
  • Sterile Alpha Motif- And Leucine Zipper-Containing Kinase AZK 4
  • Sterile Alpha Motif And Leucine Zipper Containing Kinase AZK 3
  • ZAK1 Homolog, Leucine Zipper And Sterile-Alpha Motif Kinase 3
  • Leucine Zipper- And Sterile Alpha Motif-Containing Kinase 4
  • Mixed Lineage Kinase-Related Kinase MRK-Beta 3
  • Mixed Lineage Kinase-Related Kinase 4
  • MLK-Related Kinase 4
  • EC 2.7.11.25 4
  • AC013461.1 5
  • MLTKalpha 3
  • EC 2.7.11 61
  • MLTKbeta 3
  • Mlklak 3
  • SFMMP 3
  • MLK7 3
  • MLT 3
  • AZK 3
  • PK 3

External Ids for MAP3K20 Gene

Summaries for MAP3K20 Gene

Entrez Gene Summary for MAP3K20 Gene

  • This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K20 Gene

MAP3K20 (Mitogen-Activated Protein Kinase Kinase Kinase 20) is a Protein Coding gene. Diseases associated with MAP3K20 include Split-Foot Malformation With Mesoaxial Polydactyly and Split Hand Foot Malformation 1. Among its related pathways are Tight junction and Sertoli-Sertoli Cell Junction Dynamics. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for MAP3K20 Gene

  • Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).

  • Isoform 1: Phosphorylates histone H3 at Ser-28 (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).

Gene Wiki entry for MAP3K20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K20 Gene

Genomics for MAP3K20 Gene

Regulatory Elements for MAP3K20 Gene

Enhancers for MAP3K20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F173148 1.8 FANTOM5 Ensembl ENCODE 27.5 +75.8 75792 6.1 PKNOX1 JUN ZNF384 ZNF7 ZNF316 POLR2A EED FOS MAFK ZNF202 MAP3K20 GC02P173132 PIR34994
GH02F173172 0.4 ENCODE 22.1 +97.0 96966 0.5 PKNOX1 JUNB ZNF384 FEZF1 TSHZ1 MAP3K20 GC02P173132 PIR34994
GH02F173123 1 Ensembl ENCODE 20.8 +48.8 48802 1.7 CTCF SCRT2 EED JUNB MAP3K20 GC02P173132 GC02P173085
GH02F173213 0.4 ENCODE 19.3 +138.9 138858 2.2 CTCF RAD21 YY1 ZNF316 ATF3 SMC3 NFE2 ZBTB33 MAP3K20 MAP3K20-AS1 PIR34994 GC02P173132
GH02F173226 0.2 ENCODE 19.2 +151.5 151494 1.7 SOX5 SOX13 CEBPA TCF7 CEBPB HMG20A MAP3K20 PIR34994 MAP3K20-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MAP3K20 on UCSC Golden Path with GeneCards custom track

Promoters for MAP3K20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000602551 1365 2801 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 GLIS2 FOS

Genomic Location for MAP3K20 Gene

Chromosome:
2
Start:
173,075,435 bp from pter
End:
173,268,010 bp from pter
Size:
192,576 bases
Orientation:
Plus strand

Genomic View for MAP3K20 Gene

Genes around MAP3K20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K20 Gene

Proteins for MAP3K20 Gene

  • Protein details for MAP3K20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYL2-MLTK_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase MLT
    Protein Accession:
    Q9NYL2
    Secondary Accessions:
    • B3KPG2
    • Q53SX1
    • Q580W8
    • Q59GY5
    • Q86YW8
    • Q9HCC4
    • Q9HCC5
    • Q9HDD2
    • Q9NYE9

    Protein attributes for MAP3K20 Gene

    Size:
    800 amino acids
    Molecular mass:
    91155 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer (PubMed:10924358, PubMed:26755636). Interacts with PKN1 and ZNF33A (PubMed:12535642, PubMed:12761180). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381).
    SequenceCaution:
    • Sequence=BAD92211.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP3K20 Gene

    Alternative splice isoforms for MAP3K20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K20 Gene

Selected DME Specific Peptides for MAP3K20 Gene

Post-translational modifications for MAP3K20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MAP3K20 Gene

Gene Families for MAP3K20 Gene

Suggested Antigen Peptide Sequences for MAP3K20 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYL2

UniProtKB/Swiss-Prot:

MLTK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K20: view

Function for MAP3K20 Gene

Molecular function for MAP3K20 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and Ser-165.
UniProtKB/Swiss-Prot Function:
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).
UniProtKB/Swiss-Prot Function:
Isoform 1: Phosphorylates histone H3 at Ser-28 (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).

Enzyme Numbers (IUBMB) for MAP3K20 Gene

Gene Ontology (GO) - Molecular Function for MAP3K20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 11836244
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 11836244
GO:0004709 MAP kinase kinase kinase activity IEA,IDA 11836244
genes like me logo Genes that share ontologies with MAP3K20: view
genes like me logo Genes that share phenotypes with MAP3K20: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP3K20 Gene

Localization for MAP3K20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K20 Gene

Cytoplasm. Nucleus. Note=Translocates to the nucleus upon ultraviolet B irradiation. {ECO:0000269 PubMed:15684425}.

Gene Ontology (GO) - Cellular Components for MAP3K20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm ISS,IDA --
genes like me logo Genes that share ontologies with MAP3K20: view

No data available for Subcellular locations from COMPARTMENTS for MAP3K20 Gene

Pathways & Interactions for MAP3K20 Gene

genes like me logo Genes that share pathways with MAP3K20: view

Pathways by source for MAP3K20 Gene

2 KEGG pathways for MAP3K20 Gene

SIGNOR curated interactions for MAP3K20 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP3K20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000075 cell cycle checkpoint IDA 15342622
GO:0000077 DNA damage checkpoint IMP 11836244
GO:0000165 MAPK cascade IEA --
GO:0000186 activation of MAPKK activity IEA,TAS 11836244
GO:0006468 protein phosphorylation IEA,IDA 11836244
genes like me logo Genes that share ontologies with MAP3K20: view

Drugs & Compounds for MAP3K20 Gene

(5) Drugs for MAP3K20 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for MAP3K20 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAP3K20: view

Transcripts for MAP3K20 Gene

Unigene Clusters for MAP3K20 Gene

Sterile alpha motif and leucine zipper containing kinase AZK:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K20 Gene

No ASD Table

Relevant External Links for MAP3K20 Gene

GeneLoc Exon Structure for
MAP3K20
ECgene alternative splicing isoforms for
MAP3K20

Expression for MAP3K20 Gene

SOURCE GeneReport for Unigene cluster for MAP3K20 Gene:

Hs.444451

mRNA Expression by UniProt/SwissProt for MAP3K20 Gene:

Q9NYL2-MLTK_HUMAN
Tissue specificity: Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MAP3K20 Gene

Orthologs for MAP3K20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP3K20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC459745 34
  • 99.54 (n)
ZAK 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 92 (a)
OneToOne
ZAK 34
  • 90.92 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 92 (a)
OneToOne
ZAK 34
  • 91.12 (n)
mouse
(Mus musculus)
Mammalia Zak 34 16 35
  • 87.65 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zak 34
  • 86.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZAK 34
  • 75.02 (n)
-- 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495797 34
  • 70.25 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-15i8.3 34
  • 63.16 (n)
zak 35 35
  • 63 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToOne
Species where no ortholog for MAP3K20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K20 Gene

ENSEMBL:
Gene Tree for MAP3K20 (if available)
TreeFam:
Gene Tree for MAP3K20 (if available)

Paralogs for MAP3K20 Gene

genes like me logo Genes that share paralogs with MAP3K20: view

Variants for MAP3K20 Gene

Sequence variations from dbSNP and Humsavar for MAP3K20 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_076448 Split-foot malformation with mesoaxial polydactyly (SFMMP) [MIM:616890]
rs863225437 Pathogenic 173,232,359(+) CTTGT(G/T)TAAAG intron-variant, reference, missense
rs10169914 -- 173,229,401(+) AAATT(C/G)CTTGA intron-variant
rs10170707 -- 173,129,059(+) gctga(A/G)attac intron-variant
rs10173050 -- 173,216,414(+) TTTTA(C/T)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K20 Gene

Variant ID Type Subtype PubMed ID
esv3584178 CNV loss 25503493
nsv1072048 CNV deletion 25765185
nsv1126571 CNV deletion 24896259
nsv3036 CNV insertion 18451855
nsv3037 CNV insertion 18451855
nsv834460 CNV gain 17160897
nsv834461 CNV loss 17160897
nsv953517 CNV duplication 24416366

Variation tolerance for MAP3K20 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.70; 78.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K20 Gene

Disorders for MAP3K20 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAP3K20 Gene - From: ClinVar, Swiss-Prot, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MLTK_HUMAN
  • Split-foot malformation with mesoaxial polydactyly (SFMMP) [MIM:616890]: An autosomal recessive disorder characterized by a split-foot defect, mesoaxial polydactyly, nail abnormalities of the hands, and sensorineural hearing loss. {ECO:0000269 PubMed:26755636}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MAP3K20

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K20
genes like me logo Genes that share disorders with MAP3K20: view

No data available for Genatlas for MAP3K20 Gene

Publications for MAP3K20 Gene

  1. Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif. (PMID: 10924358) Liu T.-C. … Yang J.-J. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  2. Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. (PMID: 12761180) Takahashi M. … Ono Y. (J. Biochem. 2003) 3 4 22 64
  3. MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. (PMID: 11836244) Gross E.A. … Ruggieri R. (J. Biol. Chem. 2002) 3 4 22 64
  4. Identification and characterization of a novel MAP kinase kinase kinase, MLTK. (PMID: 11042189) Gotoh I. … Nishida E. (J. Biol. Chem. 2001) 3 4 22 64
  5. Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase. (PMID: 11549352) Bloem L.J. … Wang X. (J. Mol. Cell. Cardiol. 2001) 3 4 22 64

Products for MAP3K20 Gene

Sources for MAP3K20 Gene

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