MAP3K2 Gene
protein-coding GIFtS: 60
GCID: GC02M128057
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|
mitogen-activated protein kinase kinase kinase 2
(Previous symbol: MEKK2)
| |
Aliases
for MAP3K2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitogen-Activated Protein Kinase Kinase Kinase 21 2 | | MEKK 22 3 | | MEKK21 2 3 | | MAP/ERK Kinase Kinase 22 | | MEKK2B1 2 | | EC 2.7.11.253 | | MAPK/ERK Kinase Kinase 22 3 | | MAPKKK23 | | MEK Kinase 22 3 | | |
Export aliases for MAP3K2 gene to outside databasesPrevious GC identifers: GC02M125364 GC02M125990 GC02M127968 GC02M128157 GC02M128156 GC02M127780 GC02M120369 |
Summaries
for MAP3K2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAP3K2:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentiallyactivates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directlyphosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase hasalso been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulatedsignaling process. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: M3K2_HUMAN, Q9Y2U5Function: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways byphosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics
Gene Wiki entry for MAP3K2
|
Genomic Views
for MAP3K2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP3K2 gene promoter:
SRF C/EBPbeta AP-1 ATF-2 IRF-1 POU6F1 (c2) FOXO4 IRF-7A c-Jun MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP3K2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q14.3 Ensembl cytogenetic band: 2q14.3 HGNC cytogenetic band: 2q21.1MAP3K2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M128057: view genomic region
(about GC identifiers)
Start:
|
128,056,306 bp from pter |
End:
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128,146,041 bp from pter |
Size:
|
89,736 bases |
Orientation:
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minus strand |
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Proteins
for MAP3K2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: M3K2_HUMAN, Q9Y2U5 (See
protein sequence)Recommended Name: Mitogen-activated protein kinase kinase kinase 2 Size: 619 amino acids; 69741 Da
Cofactor: Magnesium
Subunit: Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase activity(By similarity). Self-associates. Binds both upstream activators and downstream substrates in multimolecularcomplexes. Interacts (via the kinase catalytic domain) with STK38. Interacts with XIAP/BIRC4
Subcellular location: Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus
Sequence caution: Sequence=BAC11348.1; Type=Erroneous initiation;
2 PDB 3D structures from  and Proteopedia  for MAP3K2:2CU1 (3D)
2NPT (3D)
Secondary accessions: B9EG87 Q53QL9 Q53S75 Q59GZ6 Q8NC32 Q9NYK3Explore the universe of human proteins at neXtProt for MAP3K2: NX_Q9Y2U5
Post-translational modifications:
Autophosphorylated (By similarity)1
Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2U5
MAP3K2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006600.3
ENSEMBL proteins: ENSP00000387246 ENSP00000343463 ENSP00000386313
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MAP3K2 for ontologies About GeneDecksing
MAP3K2 Antibody Products:
Assay Products for MAP3K2: |
Protein
Domains /
Families
for MAP3K2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP3K2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2U5ProtoNet protein and cluster: Q9Y2U5 1 Blocks protein family: IPB000270 Octicosapeptide/Phox/Bem1p
UniProtKB/Swiss-Prot: M3K2_HUMAN, Q9Y2U5Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinasesubfamilySimilarity: Contains 1 OPR domainSimilarity: Contains 1 protein kinase domain |
Function
for MAP3K2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: M3K2_HUMAN, Q9Y2U5Function: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways byphosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamicsCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by phosphorylation on Thr-524 (By similarity)Enzyme Number (IUBMB): EC 2.7.11.251
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MAP3K2 (NM_006609) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP3K2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K2 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
MAP3K2 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for MAP3K2:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Map3k2):
MAP3K2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAP3K2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response_Function of MEF2 in T lymphocytes | | | 2 | Signal transduction_JNK pathway | | | 3 | Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis | | | 4 | TRKA Signaling | | | 5 | Signaling in Gap Junctions | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for MAP3K2
5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K2 (see all 34)
3  GeneGo (Thomson Reuters) Pathways for MAP3K2
5/6  BioSystems Pathways for MAP3K2 (see all 6)
3 
Kegg Pathways (Kegg details for MAP3K2):
MAP3K2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/40 Interacting proteins for MAP3K2 (Q9Y2U52, 3 ENSP000003434634) via UniProtKB, MINT, STRING, and/or I2D (see all 40)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
MAP3K2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAP3K2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MAP3K2 for compounds About GeneDecksing
 Browse Tocris compounds for MAP3K2
3 HMDB Compounds for MAP3K2 About this table
4 Novoseek chemical compound relationships for MAP3K2 gene About this table
Search CenterWatch for drugs/clinical trials and news about MAP3K2 / M3K2
|
Transcripts
for MAP3K2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAP3K2 gene: NM_006609.4 Unigene Cluster for MAP3K2: Mitogen-activated protein kinase kinase kinase 2 Hs.744145 [show with all ESTs]Unigene Representative Sequence: NM_0066093 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409947(uc002toj.2) ENST00000344908 ENST00000409179
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAP3K2 (NM_006609) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP3K2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K2 |
Additional cDNA sequence: AB208963.1 AF111105.1 AF239798.1 AK027345.1 AK074577.1 AK075004.1 AK093893.1 AK315007.1 BC065755.1 BC136293.1 6 DOTS entries: DT.413941 DT.75171993 DT.209266 DT.100777384 DT.95235007 DT.91982939 24/274 AceView cDNA sequences (see all 274): CK904738 BU190027 M62037 BM069841 BE892693 AA737471 BU161848 AI355336 AI219952 BU674577 CB051644 AI493824 AW182927 AI587528 BM069595 AI125541 AI400127 AW612171 BM698966 AW241634 CD673720 AI288153 AI627481 AA828446
GeneLoc Exon Structure
|
Expression
for MAP3K2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAP3K2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCATTTTTT
About this image
See MAP3K2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP3K2
SOURCE GeneReport for Unigene cluster: Hs.744145
SABiosciences Expression via Pathway-Focused PCR Arrays including MAP3K2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP3K2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP3K2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K2 |
Orthologs
for MAP3K2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MAP3K2 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MAP3K21 |
mitogen-activated protein kinase kinase kinase 2 |
82.77(n)
91.6(a) |
|
424225 XM_422075.3 XP_422075.2 |
lizard
(Anolis carolinensis) |
Reptilia |
MAP3K26 |
-- |
86(a) |
1 ↔ 1 |
GL343344.1(859293-884173) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.153882 |
Xenopus laevis transcribed sequence with moderate similarity more |
80.39(n) |
|
BJ037579.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
map3k21 |
mitogen-activated protein kinase kinase kinase 2 |
72.84(n)
82.95(a) |
|
558321 XM_681521.1 XP_686613.1 |
ENSEMBL Gene Tree for MAP3K2 (if available)
TreeFam Gene Tree for MAP3K2 (if available) |
Paralogs
for MAP3K2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAP3K2 gene
- MAP3K12 MAP3K32 MAP3K52 MAP3K152 MAP3K192 MAP3K82 MAP3K62
18/42 SIMAP similar genes for MAP3K2 using alignment to 3 protein entries: M3K2_HUMAN (see all proteins)
(see all similar genes):MST094 MAP3K3 MAP3K1 MAP3K19 MAP3K15 MAP3K5
STK11 YSK4 PAK1 PAK2 MAP3K4 MST4
STK25 MAP3K6 STK4 STK24 MARK4 TAOK2
MAP3K2 for paralogs About GeneDecksing
|
Genomic Variants
for MAP3K2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAP3K2 (128056306 - 128146041 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAP3K2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K2 |
|
Disorders
/ Diseases
for MAP3K2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAP3K2 for disorders About GeneDecksing
OMIM gene information: 609487
OMIM disorders: --
11  diseases for MAP3K2: About MalaCardsrheumatoid arthritis protein s deficiency osteoarthritis hepatitis b
arthritis prostate cancer ovarian cancer prostatitis
glioblastoma hepatitis neuroblastoma
5 Novoseek disease relationships for MAP3K2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: MAP3K2 (1 document)
Export disorders for MAP3K2 gene to outside databases
|
Publications
for MAP3K2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAP3K2 gene, integrated from 9 sources (see all 101):
(articles sorted by number of sources associating them with MAP3K2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. (PubMed id 8621389)1, 3, 9 Blank J.L....Johnson G.L. (1996)
- Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PubMed id 17906693)1, 2, 9 Enomoto A....Miyagawa K. (2008)
- XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. (PubMed id 18761086)1, 2, 9 Winsauer G....de Martin R. (2008)
- Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. (PubMed id 10713157)1, 2, 9 Cheng J.... Su B. (2000)
- MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. (PubMed id 15075238)1, 2, 9 Raviv Z.... Seger R. (2004)
- Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta. (PubMed id 10085062)1, 3, 9 Zhao Q. and Lee F.S. (1999)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae. (PubMed id 16001074)1, 2 Pelkmans L. and Zerial M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway. (PubMed id 12912994)1, 9 Nakamura K. and Johnson G.L. (2003)
|
External Searches for MAP3K2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAP3K2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAP3K2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAP3K2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAP3K2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MAP3K2 gene:
Search GeneIP for patents involving MAP3K2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAP3K2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MAP3K2 | | OriGene shRNA RFP for MAP3K2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP3K2 | | | OriGene Protein Over-expression Lysate for MAP3K2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAP3K2 | | OriGene 3'-UTR Clone for MAP3K2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MAP3K2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAP3K2 | | OriGene Custom Protein Services for MAP3K2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP3K2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MAP3K2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MAP3K2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K2 |
|  |  |  | | | | ThermoFisher Antibody for MAP3K2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K2 |
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