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MAP3K2 Gene

protein-coding   GIFtS: 63
GCID: GC02M128057

Mitogen-Activated Protein Kinase Kinase Kinase 2


(Previous symbol: MEKK2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 21 2     MEKK 22 3
MEKK21 2 3     MEKK2B2
MAP/ERK Kinase Kinase 21 2     EC 2.7.11.253
MAPK/ERK Kinase Kinase 22 3     MAPKKK23
MEK Kinase 22 3     

External Ids:    HGNC: 68541   Entrez Gene: 107462   Ensembl: ENSG000001699677   OMIM: 6094875   UniProtKB: Q9Y2U53   

Export aliases for MAP3K2 gene to outside databases

Previous GC identifers: GC02M125364 GC02M125990 GC02M127968 GC02M128157 GC02M128156 GC02M127780 GC02M120369


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP3K2 Gene:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially
activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly
phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase
has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a
regulated signaling process. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP3K2 Gene:
MAP3K2 (mitogen-activated protein kinase kinase kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is MAP3K1.

UniProtKB/Swiss-Prot: M3K2_HUMAN, Q9Y2U5
Function: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by
phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics

Gene Wiki entry for MAP3K2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP3K2 gene promoter:
         SRF   C/EBPbeta   AP-1   ATF-2   IRF-1   POU6F1 (c2)   FOXO4   IRF-7A   c-Jun   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP3K2 promoter sequence
   Search Chromatin IP Primers for MAP3K2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP3K2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.3   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q21.1

MAP3K2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M128057:  view genomic region     (about GC identifiers)

Start:
128,056,245 bp from pter      End:
128,146,041 bp from pter
Size:
89,797 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: M3K2_HUMAN, Q9Y2U5 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 2  
Size: 619 amino acids; 69741 Da
Cofactor: Magnesium
Subunit: Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase
activity (By similarity). Self-associates. Binds both upstream activators and downstream substrates in
multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. Interacts with XIAP/BIRC4
Sequence caution: Sequence=BAC11348.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for MAP3K2:
2CU1 (3D)        2NPT (3D)    
Secondary accessions: B9EG87 Q53QL9 Q53S75 Q59GZ6 Q8NC32 Q9NYK3

Explore the universe of human proteins at neXtProt for MAP3K2: NX_Q9Y2U5

Explore proteomics data for MAP3K2 at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation1
  • Ubiquitination2 at Lys602
  • Modification sites at PhosphoSitePlus

  • See MAP3K2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006600.3  
    ENSEMBL proteins: 
     ENSP00000387246   ENSP00000343463   ENSP00000386313  

    MAP3K2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MAP3K2

     
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    antibodies-online proteins for MAP3K2 (2 products) 

     
    antibodies-online peptides for MAP3K2

    MAP3K2 Antibody Products:

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    antibodies-online antibodies for MAP3K2 (38 products) 

    MAP3K2 Assay Products:

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    Cloud-Clone Corp. ELISAs for MAP3K2
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    antibodies-online kits for MAP3K2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 2
    STE11 family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR000270 OPR_PB1

    Graphical View of Domain Structure for InterPro Entry Q9Y2U5

    ProtoNet protein and cluster: Q9Y2U5

    1 Blocks protein domain: IPB000270 Octicosapeptide/Phox/Bem1p

    UniProtKB/Swiss-Prot: M3K2_HUMAN, Q9Y2U5
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAP3K2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K2_HUMAN, Q9Y2U5
    Function: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by
    phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-524 (By similarity)

         Enzyme Number (IUBMB): EC 2.7.11.251

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA15001576
    GO:0004674protein serine/threonine kinase activity TAS8621389
    GO:0004709MAP kinase kinase kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with MAP3K2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAP3K2:
     Decreased focal adhesion (FA)   Decreased telomerase activity  Increased circadian period len  Increased viability with 4OH t 
     Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Map3k2):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  reproductive system 

    Find genes that share phenotypes with MAP3K2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Map3k2tm1Rdbr for MAP3K2

       genOway: Develop your customized and physiologically relevant rodent model for MAP3K2

    miRNA
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    miRTarBase miRNAs that target MAP3K2:
    hsa-mir-125b-5p (MIRT045942), hsa-mir-615-3p (MIRT040386), hsa-mir-21-5p (MIRT030767), hsa-mir-520b (MIRT006282), hsa-mir-92b-3p (MIRT040708), hsa-mir-26a-5p (MIRT003212)

    Block miRNA regulation of human, mouse, rat MAP3K2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP3K2 (see all 248):
    hsa-miR-640 hsa-miR-520f hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-759 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP3K2
    Predesigned siRNA for gene silencing in human, mouse, rat MAP3K2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MAP3K2 (NM_006609)
    Sino Biological Human cDNA Clone for MAP3K2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K2
    Addgene plasmids for MAP3K2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    M3K2_HUMAN, Q9Y2U5: Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with MAP3K2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP3K2 About   (see all 36)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    2NGF Pathway
    TRKA Signaling0.75
    NGF Pathway0.75
    3NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72
    4TCR Signaling (Qiagen)
    PKC-Theta Pathway0.68
    TCR Signaling0.68
    5Integrin Pathway
    Integrin Pathway0.67
    GnRH Signaling0.56


    Find genes that share SuperPaths with MAP3K2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP3K2 (see all 34)
        Antioxidant Action of Vitamin-C
    Interferon Pathway
    TRKA Signaling
    ERK5 Signaling
    PACAP Signaling

    3 GeneGo (Thomson Reuters) Pathways for MAP3K2
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction JNK pathway
    Immune response Function of MEF2 in T lymphocytes

    Selected BioSystems Pathways for MAP3K2 (see all 7)
        EGFR1 Signaling Pathway
    Insulin Signaling
    BDNF signaling pathway
    MAPK Cascade
    TNF-alpha/NF-kB Signaling Pathway

    1 Sino Biological Pathway for MAP3K2
        Death Receptor Signaling


    3 Kegg Pathways  (Kegg details for MAP3K2):
        MAPK signaling pathway
    Gap junction
    GnRH signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP3K2: 
              EGF / PDGF Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP3K2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP3K2 (Q9Y2U51, 2, 3 ENSP000003434634) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STUB1Q9UNE71, 2, 3, ENSP000002195484EBI-357393,EBI-357085 MINT-8010534 MINT-8012530 MINT-8010505 MINT-8010493 MINT-8010517 MINT-8010584 MINT-7996786 MINT-8010565 MINT-8010548 MINT-8010453 I2D: score=2 STRING: ENSP00000219548
    MAP3K3Q997592, 3MINT-48479 I2D: score=2 
    SFNP319472, 3MINT-3975452 I2D: score=2 
    MAP3K5Q996832, 3, ENSP000003519084MINT-18083 MINT-18082 I2D: score=2 STRING: ENSP00000351908
    UBCP0CG482, 3, ENSP000003448184MINT-8010627 I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000186activation of MAPKK activity ----
    GO:0000187activation of MAPK activity TAS8621389
    GO:0006468protein phosphorylation TAS8621389
    GO:0007257activation of JUN kinase activity TAS8621389

    Find genes that share ontologies with MAP3K2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP3K2 (M3K2)

    3 HMDB Compounds for MAP3K2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    4 Novoseek inferred chemical compound relationships for MAP3K2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anisomycin 70.9 2 10347227 (1), 17699104 (1)
    lysine 6.27 1 11343802 (1)
    serine 3.61 5 11343802 (2), 16362041 (1)
    tyrosine 0 2 15242770 (1), 11032806 (1)



    Find genes that share compounds with MAP3K2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAP3K2 gene: 
    NM_006609.4  

    Unigene Cluster for MAP3K2:

    Mitogen-activated protein kinase kinase kinase 2
    Hs.145605  [show with all ESTs]
    Unigene Representative Sequence: NM_006609
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409947(uc002toj.2) ENST00000344908 ENST00000409179
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAP3K2 (see all 248):
    hsa-miR-640 hsa-miR-520f hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-759 hsa-miR-3921
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      QuantiFast Probe-based Assays in human, mouse, rat MAP3K2

    Additional mRNA sequence: 

    AB208963.1 AF111105.1 AF239798.1 AK027345.1 AK074577.1 AK075004.1 AK093893.1 AK315007.1 
    BC065755.1 BC136293.1 

    6 DOTS entries:

    DT.413941  DT.75171993  DT.209266  DT.100777384  DT.95235007  DT.91982939 

    Selected AceView cDNA sequences (see all 274):

    BU161848 M62037 AW664500 AW850061 AW197617 AA737471 AW241634 CB068847 
    AI813319 AI493824 AA828446 BU190027 AI627481 CB306247 AI219952 CK904737 
    BU167694 AK075004 BM069841 AI400127 CB051644 BM698966 AA757873 CK904738 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP3K2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCATTTTTT
    MAP3K2 Expression
    About this image


    MAP3K2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Retina
    MAP3K2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP3K2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.145605
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP3K2: 
              EGF / PDGF Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MAP3K2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP3K2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k21 , 5 mitogen-activated protein kinase kinase kinase 21, 5 91.98(n)1
    96.28(a)1
      18 (17.95 cM)5
    264051  NM_011946.31  NP_036076.21 
     321630895 
    chicken
    (Gallus gallus)
    Aves MAP3K21 mitogen-activated protein kinase kinase kinase 2 82.59(n)
    91.63(a)
      424225  XM_004942888.1  XP_004942945.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K26
    mitogen-activated protein kinase kinase kinase 2
    86(a)
    1 ↔ 1
    GL343344.1(859293-884173)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153882 Xenopus laevis transcribed sequence with moderate similarity more 80.39(n)    BJ037579.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map3k21 mitogen-activated protein kinase kinase kinase 2 72.73(n)
    82.79(a)
      558321  XM_681521.2  XP_686613.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE116
    Signal transducing MEK kinase involved in pheromon...
    24(a)
    1 → many
    XII(849866-852019) YLR362W


    ENSEMBL Gene Tree for MAP3K2 (if available)
    TreeFam Gene Tree for MAP3K2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP3K2 gene
    MAP3K12  MAP3K32  MAP3K52  MAP3K152  MAP3K82  MAP3K192  MAP3K62  
    Selected SIMAP similar genes for MAP3K2 using alignment to 3 protein entries:     M3K2_HUMAN (see all proteins) (see all similar genes):
    MST094    MAP3K3    MAP3K1    MAP3K19    MAP3K15    MAP3K5
    STK11    YSK4    PAK1    PAK2    MAP3K4    MST4
    STK25    MAP3K6    STK4    STK24    MARK4    TAOK2

    Find genes that share paralogs with MAP3K2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP3K2 (see all 940)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406834
    A lung large cell carcinoma sample4--see VAR_0406832 M I mis40--------
    rs46625801,2
    C,F,H--127601977(+) acagaC/Actgca 1 -- us2k121Minor allele frequency- A:0.44NS EA NA WA CSA 2704
    rs75641891,2
    C,F,A--128055858(+) gaacgC/Tgggag 1 -- ds50012Minor allele frequency- T:0.50NA WA 4
    rs75900301,2
    C,F,A,H--128055967(+) CTCCAA/GCACCA 1 -- ds500125Minor allele frequency- G:0.20NS EA NA WA CSA 2485
    rs1844799301,2
    --128056020(+) GTTTGG/TGTTTG 1 -- ds50010--------
    rs1891835531,2
    --128056095(+) GTGGAA/GCATTA 1 -- ds50010--------
    rs1390101421,2
    C--128056111(+) TTAGAC/TACTGG 1 -- ds50010--------
    rs1818099981,2
    C--128056114(+) GATACC/TGGAAA 1 -- ds50010--------
    rs1163155241,2
    C,F--128056157(+) TCTGCG/ACTTGG 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1863640731,2
    C--128056164(+) TTGGTC/TTCCTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MAP3K2 (128056245 - 128146041 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAP3K2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP3K2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609487    OMIM disorders: --


    Find genes that share disorders with MAP3K2           About GenesLikeMe

    5 Novoseek inferred disease relationships for MAP3K2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 21.2 1 17559674 (1)
    necrosis 13 2 11097748 (1), 15242770 (1)
    prostate cancer 11.1 1 17695723 (1)
    osteoarthritis 1.9 1 14734742 (1)
    tumors 0 2 15242770 (1), 19690195 (1)

    Genetic Association Database (GAD): MAP3K2
    Human Genome Epidemiology (HuGE) Navigator: MAP3K2 (1 document)

    Export disorders for MAP3K2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP3K2 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with MAP3K2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. (PubMed id 8621389)1, 3, 9 Blank J.L....Johnson G.L. (J. Biol. Chem. 1996)
    2. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PubMed id 17906693)1, 2, 9 Enomoto A.... Miyagawa K. (Oncogene 2008)
    3. XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. (PubMed id 18761086)1, 2, 9 Winsauer G.... de Martin R. (Cell. Signal. 2008)
    4. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. (PubMed id 10713157)1, 2, 9 Cheng J.... Su B. (Mol. Cell. Biol. 2000)
    5. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. (PubMed id 15075238)1, 2, 9 Raviv Z.... Seger R. (J. Cell Sci. 2004)
    6. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta. (PubMed id 10085062)1, 3, 9 Zhao Q. and Lee F.S. (J. Biol. Chem. 1999)
    7. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae. (PubMed id 16001074)1, 2 Pelkmans L. and Zerial M. (Nature 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10746 HGNC: 6854 AceView: MAP3K2 Ensembl:ENSG00000169967 euGenes: HUgn10746
    ECgene: MAP3K2 Kegg: 10746 H-InvDB: MAP3K2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP3K2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP3K2 gene:
    Search GeneIP for patents involving MAP3K2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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