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Aliases for MAP3K2 Gene

Aliases for MAP3K2 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 2 2 3
  • MAPK/ERK Kinase Kinase 2 3 4
  • MAP/ERK Kinase Kinase 2 2 3
  • MEK Kinase 2 3 4
  • MEKK 2 3 4
  • MEKK2 3 4
  • EC 4
  • MAPKKK2 4
  • MEKK2B 3

External Ids for MAP3K2 Gene

Previous Symbols for MAP3K2 Gene

  • MEKK2

Summaries for MAP3K2 Gene

Entrez Gene Summary for MAP3K2 Gene

  • The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K2 Gene

MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Development FGFR signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is MAP3K5.

UniProtKB/Swiss-Prot for MAP3K2 Gene

  • Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.

Gene Wiki entry for MAP3K2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K2 Gene

Genomics for MAP3K2 Gene

Genomic Location for MAP3K2 Gene

127,298,669 bp from pter
127,388,465 bp from pter
89,797 bases
Minus strand

Genomic View for MAP3K2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP3K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K2 Gene

Regulatory Elements for MAP3K2 Gene

Proteins for MAP3K2 Gene

  • Protein details for MAP3K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 2
    Protein Accession:
    Secondary Accessions:
    • B9EG87
    • Q53QL9
    • Q53S75
    • Q59GZ6
    • Q8NC32
    • Q9NYK3

    Protein attributes for MAP3K2 Gene

    619 amino acids
    Molecular mass:
    69741 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase activity (By similarity). Self-associates. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. Interacts with XIAP/BIRC4.
    • Sequence=BAC11348.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP3K2 Gene

neXtProt entry for MAP3K2 Gene

Proteomics data for MAP3K2 Gene at MOPED

Post-translational modifications for MAP3K2 Gene

Other Protein References for MAP3K2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP3K2 Gene

Domains for MAP3K2 Gene

Gene Families for MAP3K2 Gene

  • MAP3K :Mitogen-activated protein kinase cascade / Kinase kinase kinases

Suggested Antigen Peptide Sequences for MAP3K2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PB1 domain.:
    • Q9Y2U5
  • Contains 1 protein kinase domain.:
    • Q9Y2U5
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.:
    • Q9Y2U5
genes like me logo Genes that share domains with MAP3K2: view

Function for MAP3K2 Gene

Molecular function for MAP3K2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on Thr-524.
UniProtKB/Swiss-Prot Function: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.

Enzyme Numbers (IUBMB) for MAP3K2 Gene

Gene Ontology (GO) - Molecular Function for MAP3K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 15001576
GO:0004674 protein serine/threonine kinase activity TAS 8621389
GO:0004708 MAP kinase kinase activity IBA --
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with MAP3K2: view
genes like me logo Genes that share phenotypes with MAP3K2: view

Animal Models for MAP3K2 Gene

MGI Knock Outs for MAP3K2:

No data available for Transcription Factor Targeting and HOMER Transcription for MAP3K2 Gene

Localization for MAP3K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K2 Gene

Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus.

Subcellular locations from

Jensen Localization Image for MAP3K2 Gene COMPARTMENTS Subcellular localization image for MAP3K2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MAP3K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with MAP3K2: view

Pathways for MAP3K2 Gene

genes like me logo Genes that share pathways with MAP3K2: view

Gene Ontology (GO) - Biological Process for MAP3K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade --
GO:0000186 activation of MAPKK activity IEA --
GO:0000187 activation of MAPK activity TAS 8621389
GO:0006468 protein phosphorylation IEA --
GO:0007257 activation of JUN kinase activity TAS 8621389
genes like me logo Genes that share ontologies with MAP3K2: view

Compounds for MAP3K2 Gene

(3) HMDB Compounds for MAP3K2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium

(4) Novoseek inferred chemical compound relationships for MAP3K2 Gene

Compound -log(P) Hits PubMed IDs
anisomycin 70.9 2
lysine 6.27 1
serine 3.61 3
tyrosine 0 2
genes like me logo Genes that share compounds with MAP3K2: view

Transcripts for MAP3K2 Gene

mRNA/cDNA for MAP3K2 Gene

Unigene Clusters for MAP3K2 Gene

Mitogen-activated protein kinase kinase kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K2 Gene

No ASD Table

Relevant External Links for MAP3K2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP3K2 Gene

mRNA expression in normal human tissues for MAP3K2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K2 Gene

This gene is overexpressed in Whole Blood (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP3K2 Gene

SOURCE GeneReport for Unigene cluster for MAP3K2 Gene Hs.145605

genes like me logo Genes that share expressions with MAP3K2: view

No data available for mRNA Expression by UniProt/SwissProt for MAP3K2 Gene

Orthologs for MAP3K2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP3K2 35
  • 99.78 (n)
  • 99.84 (a)
MAP3K2 36
  • 100 (a)
(Bos Taurus)
Mammalia MAP3K2 35
  • 93.91 (n)
  • 97.74 (a)
MAP3K2 36
  • 92 (a)
(Canis familiaris)
Mammalia MAP3K2 35
  • 95.42 (n)
  • 98.87 (a)
MAP3K2 36
  • 99 (a)
(Mus musculus)
Mammalia Map3k2 35
  • 91.98 (n)
  • 96.28 (a)
Map3k2 16
Map3k2 36
  • 96 (a)
(Monodelphis domestica)
Mammalia MAP3K2 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia MAP3K2 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Map3k2 35
  • 90.74 (n)
  • 96.12 (a)
(Gallus gallus)
Aves MAP3K2 35
  • 82.59 (n)
  • 91.63 (a)
MAP3K2 36
  • 91 (a)
(Anolis carolinensis)
Reptilia MAP3K2 36
  • 86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15388 35
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k2 35
  • 77.74 (n)
  • 87.68 (a)
Str.7239 35
(Danio rerio)
Actinopterygii map3k2 35
  • 72.73 (n)
  • 82.79 (a)
MAP3K2 36
  • 82 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for MAP3K2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K2 Gene

Gene Tree for MAP3K2 (if available)
Gene Tree for MAP3K2 (if available)

Paralogs for MAP3K2 Gene

Paralogs for MAP3K2 Gene

genes like me logo Genes that share paralogs with MAP3K2: view

Variants for MAP3K2 Gene

Sequence variations from dbSNP and Humsavar for MAP3K2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9923 -- 127,306,270(+) AGCCT(C/T)AGCAC utr-variant-3-prime
rs10850 -- 127,306,369(+) TCATG(C/T)TACTA utr-variant-3-prime
rs15521 -- 127,303,040(+) aatta(C/T)taata utr-variant-3-prime
rs867304 -- 127,320,912(+) cccaa(A/G)agttc intron-variant
rs867329 -- 127,321,537(-) CTGGA(C/T)TGCAA intron-variant

Relevant External Links for MAP3K2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAP3K2 Gene

Disorders for MAP3K2 Gene

(5) Novoseek inferred disease relationships for MAP3K2 Gene

Disease -log(P) Hits PubMed IDs
rheumatoid arthritis 21.2 1
necrosis 13 2
prostate cancer 11.1 1
osteoarthritis 1.9 1
tumors 0 2

Relevant External Links for MAP3K2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAP3K2: view

No data available for UniProtKB/Swiss-Prot for MAP3K2 Gene

Publications for MAP3K2 Gene

  1. Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. (PMID: 8621389) Blank J.L. … Johnson G.L. (J. Biol. Chem. 1996) 2 3 23
  2. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. (PMID: 10713157) Cheng J. … Su B. (Mol. Cell. Biol. 2000) 3 4 23
  3. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta. (PMID: 10085062) Zhao Q. … Lee F.S. (J. Biol. Chem. 1999) 2 3 23
  4. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. (PMID: 15075238) Raviv Z. … Seger R. (J. Cell Sci. 2004) 3 4 23
  5. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PMID: 17906693) Enomoto A. … Miyagawa K. (Oncogene 2008) 3 4 23

Products for MAP3K2 Gene

Sources for MAP3K2 Gene

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