Aliases for MAP3K2 Gene
External Ids for MAP3K2 Gene
Previous HGNC Symbols for MAP3K2 Gene
Previous GeneCards Identifiers for MAP3K2 Gene
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP3K2 Gene
MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2) is a Protein Coding gene. Among its related pathways are Trk receptor signaling mediated by the MAPK pathway and Signaling in Gap Junctions. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K3.
UniProtKB/Swiss-Prot for MAP3K2 Gene
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.