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Aliases for MAP3K2 Gene

Aliases for MAP3K2 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 2 2 3 5
  • MAPK/ERK Kinase Kinase 2 3 4
  • MAP/ERK Kinase Kinase 2 2 3
  • MEK Kinase 2 3 4
  • MEKK 2 3 4
  • MEKK2 3 4
  • EC 2.7.11.25 4
  • MAPKKK2 4
  • MEKK2B 3

External Ids for MAP3K2 Gene

Previous HGNC Symbols for MAP3K2 Gene

  • MEKK2

Previous GeneCards Identifiers for MAP3K2 Gene

  • GC02M125364
  • GC02M125990
  • GC02M127968
  • GC02M128157
  • GC02M128156
  • GC02M127780
  • GC02M120369
  • GC02M128057

Summaries for MAP3K2 Gene

Entrez Gene Summary for MAP3K2 Gene

  • The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K2 Gene

MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2) is a Protein Coding gene. Among its related pathways are Trk receptor signaling mediated by the MAPK pathway and Signaling in Gap Junctions. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K3.

UniProtKB/Swiss-Prot for MAP3K2 Gene

  • Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.

Gene Wiki entry for MAP3K2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K2 Gene

Genomics for MAP3K2 Gene

Regulatory Elements for MAP3K2 Gene

Enhancers for MAP3K2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G127413 1.9 FANTOM5 Ensembl ENCODE dbSUPER 32.5 -26.8 -26779 4.3 HDGF HNRNPUL1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS ERCC3 MAP3K2 SFT2D3 ENSG00000236682 AMMECR1L IWS1 PROC GC02P127390
GH02G127385 1.8 FANTOM5 ENCODE dbSUPER 33.1 +0.0 39 5.4 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ENSG00000236682 ERCC3 MAP3K2 GPR17 SFT2D3 WDR33 AMMECR1L GC02P127380
GH02G127400 1.3 Ensembl ENCODE dbSUPER 25.3 -13.4 -13380 2.8 INSM2 ARID4B GLIS2 EGR1 ZNF366 SCRT2 FOS SSRP1 SMARCA4 ZBTB33 ERCC3 MAP3K2 GC02P127390 PROC
GH02G127224 1.3 Ensembl ENCODE 17 +162.2 162172 2.7 PKNOX1 FOXA2 SIN3A FEZF1 GATA2 CBX5 KLF7 FOS ZNF263 ZHX2 ERCC3 MAP3K2 ENSG00000236682 CYP27C1 GC02P127197
GH02G127437 1 ENCODE 20.3 -49.9 -49906 1.3 HNRNPUL1 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 GATA2 ERCC3 ENSG00000236682 MAP3K2 RNU4-48P BIN1 LIMS2 MIR4783 ENSG00000231731
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP3K2 on UCSC Golden Path with GeneCards custom track

Promoters for MAP3K2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000122846 1165 2601 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for MAP3K2 Gene

Chromosome:
2
Start:
127,298,669 bp from pter
End:
127,388,465 bp from pter
Size:
89,797 bases
Orientation:
Minus strand

Genomic View for MAP3K2 Gene

Genes around MAP3K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K2 Gene

Proteins for MAP3K2 Gene

  • Protein details for MAP3K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2U5-M3K2_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 2
    Protein Accession:
    Q9Y2U5
    Secondary Accessions:
    • B9EG87
    • Q53QL9
    • Q53S75
    • Q59GZ6
    • Q8NC32
    • Q9NYK3

    Protein attributes for MAP3K2 Gene

    Size:
    619 amino acids
    Molecular mass:
    69741 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase activity (By similarity). Self-associates. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. Interacts with XIAP/BIRC4.
    SequenceCaution:
    • Sequence=BAC11348.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP3K2 Gene

neXtProt entry for MAP3K2 Gene

Post-translational modifications for MAP3K2 Gene

Other Protein References for MAP3K2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP3K2 Gene

Domains & Families for MAP3K2 Gene

Protein Domains for MAP3K2 Gene

Suggested Antigen Peptide Sequences for MAP3K2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2U5

UniProtKB/Swiss-Prot:

M3K2_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K2: view

Function for MAP3K2 Gene

Molecular function for MAP3K2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-524.
UniProtKB/Swiss-Prot Function:
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.

Enzyme Numbers (IUBMB) for MAP3K2 Gene

Gene Ontology (GO) - Molecular Function for MAP3K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IDA 15001576
GO:0004674 protein serine/threonine kinase activity TAS 8621389
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity IBA --
GO:0004709 MAP kinase kinase kinase activity IEA --
genes like me logo Genes that share ontologies with MAP3K2: view
genes like me logo Genes that share phenotypes with MAP3K2: view

Animal Models for MAP3K2 Gene

MGI Knock Outs for MAP3K2:

Animal Model Products

miRNA for MAP3K2 Gene

miRTarBase miRNAs that target MAP3K2

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K2 Gene

Localization for MAP3K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K2 Gene

Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K2 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for MAP3K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MAP3K2: view

Pathways & Interactions for MAP3K2 Gene

genes like me logo Genes that share pathways with MAP3K2: view

SIGNOR curated interactions for MAP3K2 Gene

Activates:

Gene Ontology (GO) - Biological Process for MAP3K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0000187 activation of MAPK activity TAS 8621389
GO:0006468 protein phosphorylation TAS 8621389
GO:0007257 activation of JUN kinase activity TAS 8621389
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP3K2: view

Drugs & Compounds for MAP3K2 Gene

(17) Drugs for MAP3K2 Gene - From: DrugBank, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
bosutinib Approved Pharma Target, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Bosulif Approved September 2012 Pharma 0
Adenosine triphosphate Approved Nutra 0
AZD6244 (Selumetinib) Pharma MEK inhibitor 0
PD0325901 Pharma MEK inhibitor, Kinase Inhibitors, Potent inhibitor of MEK1/2 0

(1) Additional Compounds for MAP3K2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(9) ApexBio Compounds for MAP3K2 Gene

Compound Action Cas Number
AZD6244 (Selumetinib) MEK inhibitor 606143-52-6
PD0325901 MEK inhibitor 391210-10-9
PD98059 MEK inhibitor,selective and reversible 167869-21-8
Pimasertib (AS-703026) MEK1/2 inhibitor 1236699-92-5
SCH772984 ERK1 and ERK2 inhibitor 942183-80-4
SL-327 Selective MEK1/2 inhibitor 305350-87-2
Trametinib (GSK1120212) MEK1 and MEK2 inhibitor, potent and selective 871700-17-3
U0126-EtOH MEK1/2 inhibitor 1173097-76-1
Vemurafenib (PLX4032, RG7204) BRAF kinase inhibitor 918504-65-1
genes like me logo Genes that share compounds with MAP3K2: view

Drug Products

Transcripts for MAP3K2 Gene

mRNA/cDNA for MAP3K2 Gene

Unigene Clusters for MAP3K2 Gene

Mitogen-activated protein kinase kinase kinase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K2 Gene

No ASD Table

Relevant External Links for MAP3K2 Gene

GeneLoc Exon Structure for
MAP3K2
ECgene alternative splicing isoforms for
MAP3K2

Expression for MAP3K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP3K2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K2 Gene

This gene is overexpressed in Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for MAP3K2 Gene

This gene is overexpressed in Plasma (29.5), Peripheral blood mononuclear cells (8.8), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP3K2 Gene



Protein tissue co-expression partners for MAP3K2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP3K2 Gene:

MAP3K2

SOURCE GeneReport for Unigene cluster for MAP3K2 Gene:

Hs.145605

Evidence on tissue expression from TISSUES for MAP3K2 Gene

  • Nervous system(4.5)
  • Blood(4.3)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with MAP3K2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K2 Gene

Orthologs for MAP3K2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP3K2 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia MAP3K2 34 35
  • 95.42 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP3K2 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP3K2 34 35
  • 93.91 (n)
mouse
(Mus musculus)
Mammalia Map3k2 34 16 35
  • 91.98 (n)
rat
(Rattus norvegicus)
Mammalia Map3k2 34
  • 90.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K2 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP3K2 34 35
  • 82.59 (n)
lizard
(Anolis carolinensis)
Reptilia MAP3K2 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k2 34
  • 77.74 (n)
Str.7239 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15388 34
zebrafish
(Danio rerio)
Actinopterygii MAP3K2 35
  • 82 (a)
OneToOne
map3k2 34
  • 72.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToMany
Species where no ortholog for MAP3K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K2 Gene

ENSEMBL:
Gene Tree for MAP3K2 (if available)
TreeFam:
Gene Tree for MAP3K2 (if available)

Paralogs for MAP3K2 Gene

Variants for MAP3K2 Gene

Sequence variations from dbSNP and Humsavar for MAP3K2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_040683 A lung large cell carcinoma sample
rs1000010255 -- 127,325,146(+) GATTT(C/G)CCTTC intron-variant
rs1000062610 -- 127,324,769(+) GCAAT(A/G)TTAGT intron-variant
rs1000124559 -- 127,342,588(+) CTCCA(C/T)TTCCT intron-variant
rs1000294881 -- 127,323,172(+) CAAGG(C/T)AAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K2 Gene

Variant ID Type Subtype PubMed ID
esv3584056 CNV loss 25503493

Variation tolerance for MAP3K2 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K2 Gene

Disorders for MAP3K2 Gene

Relevant External Links for MAP3K2

Genetic Association Database (GAD)
MAP3K2
Human Genome Epidemiology (HuGE) Navigator
MAP3K2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K2

No disorders were found for MAP3K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K2 Gene

Publications for MAP3K2 Gene

  1. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PMID: 17906693) Enomoto A. … Miyagawa K. (Oncogene 2008) 3 4 22 64
  2. XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. (PMID: 18761086) Winsauer G. … de Martin R. (Cell. Signal. 2008) 3 4 22 64
  3. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. (PMID: 15075238) Raviv Z. … Seger R. (J. Cell Sci. 2004) 3 4 22 64
  4. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. (PMID: 10713157) Cheng J. … Su B. (Mol. Cell. Biol. 2000) 3 4 22 64
  5. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta. (PMID: 10085062) Zhao Q. … Lee F.S. (J. Biol. Chem. 1999) 2 3 22 64

Products for MAP3K2 Gene

Sources for MAP3K2 Gene

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