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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K2 Gene

protein-coding   GIFtS: 64
GCID: GC02M128057

Mitogen-Activated Protein Kinase Kinase Kinase 2


(Previous symbol: MEKK2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 21 2     MEKK 22 3
MEKK21 2 3     MEKK2B2
MAP/ERK Kinase Kinase 21 2     EC 2.7.11.253
MAPK/ERK Kinase Kinase 22 3     MAPKKK23
MEK Kinase 22 3     

External Ids:    HGNC: 68541   Entrez Gene: 107462   Ensembl: ENSG000001699677   OMIM: 6094875   UniProtKB: Q9Y2U53   

Export aliases for MAP3K2 gene to outside databases

Previous GC identifers: GC02M125364 GC02M125990 GC02M127968 GC02M128157 GC02M128156 GC02M127780 GC02M120369


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP3K2 Gene:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially
activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly
phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase
has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a
regulated signaling process. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP3K2 Gene: 
MAP3K2 (mitogen-activated protein kinase kinase kinase 2) is a protein-coding gene. Diseases associated with MAP3K2 include cerebral cavernous malformations-2, and cerebral cavernous malformation, and among its related super-pathways are Gap junction and NGF Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is MAP3K1.

UniProtKB/Swiss-Prot: M3K2_HUMAN, Q9Y2U5
Function: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by
phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics

Gene Wiki entry for MAP3K2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K2 gene promoter:
         SRF   C/EBPbeta   AP-1   ATF-2   IRF-1   POU6F1 (c2)   FOXO4   IRF-7A   c-Jun   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP3K2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP3K2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.3   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q21.1

MAP3K2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M128057:  view genomic region     (about GC identifiers)

Start:
128,056,245 bp from pter      End:
128,146,041 bp from pter
Size:
89,797 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M3K2_HUMAN, Q9Y2U5 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 2  
Size: 619 amino acids; 69741 Da
Cofactor: Magnesium
Subunit: Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase
activity (By similarity). Self-associates. Binds both upstream activators and downstream substrates in
multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. Interacts with XIAP/BIRC4
Subcellular location: Cytoplasm. Nucleus. Note=Upon EGF stimulation, translocates into the nucleus
Sequence caution: Sequence=BAC11348.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for MAP3K2:
2CU1 (3D)        2NPT (3D)    
Secondary accessions: B9EG87 Q53QL9 Q53S75 Q59GZ6 Q8NC32 Q9NYK3

Explore the universe of human proteins at neXtProt for MAP3K2: NX_Q9Y2U5

Explore proteomics data for MAP3K2 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated (By similarity)
  • UniProtKB: Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2U5

  • MAP3K2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP3K2 Protein Expression
    REFSEQ proteins: NP_006600.3  
    ENSEMBL proteins: 
     ENSP00000387246   ENSP00000343463   ENSP00000386313  

    Human Recombinant Protein Products for MAP3K2: 
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    Novus Biologicals MAP3K2 Protein
    Novus Biologicals MAP3K2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP3K2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    MAP3K2 for ontologies           About GeneDecksing



    MAP3K2 Antibody Products: 
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    ThermoFisher Antibody for MAP3K2
    LSBio Antibodies in human, mouse, rat for MAP3K2 

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    Cloud-Clone Corp. ELISAs for MAP3K2 
    Cloud-Clone Corp. CLIAs for MAP3K2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 2 
    STE11 family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR000270 OPR_PB1

    Graphical View of Domain Structure for InterPro Entry Q9Y2U5

    ProtoNet protein and cluster: Q9Y2U5

    1 Blocks protein domain: IPB000270 Octicosapeptide/Phox/Bem1p

    UniProtKB/Swiss-Prot: M3K2_HUMAN, Q9Y2U5
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 protein kinase domain


    MAP3K2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K2_HUMAN, Q9Y2U5
    Function: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by
    phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-524 (By similarity)

         Enzyme Number (IUBMB): EC 2.7.11.251

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA15001576
    GO:0004674protein serine/threonine kinase activity TAS8621389
    GO:0004709MAP kinase kinase kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
         
    MAP3K2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAP3K2:
     Decreased focal adhesion (FA)   Decreased telomerase activity  Increased circadian period len  Increased viability with 4OH t 
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Map3k2):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     reproductive system 

    MAP3K2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Map3k2tm1Rdbr for MAP3K2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP3K2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP3K2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP3K2 

    miRNA
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    miRTarBase miRNAs that target MAP3K2:
    hsa-mir-26a (MIRT003212)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K2
    8/248 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K2 (see all 248):
    hsa-miR-640 hsa-miR-520f hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-759 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K2
    Sirion Biotech Customized lentivirus for stable overexpression of MAP3K2 
                         Customized lentivirus expression plasmids for stable overexpression of MAP3K2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAP3K2 About   (see all 37)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling in Gap Junctions
    Signaling in Gap Junctions0.31
    Gap junction0.31
    2TRKA Signaling
    TRKA Signaling0.75
    NGF Pathway0.75
    3NF-KappaB Family Pathway
    NF-KappaB Family Pathway0.72
    NF-KappaB (p50-p65) Pathway0.72
    4PKC-Theta Pathway
    TCR Signaling0.68
    PKC-Theta Pathway0.68
    5Integrin Pathway
    Integrin Pathway0.67
    GnRH Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for MAP3K2
        Immune response Function of MEF2 in T lymphocytes
    Signal transduction JNK pathway
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K2 (see all 34)
        Antioxidant Action of Vitamin-C
    Interferon Pathway
    TRKA Signaling
    ERK5 Signaling
    PACAP Signaling

    3 GeneGo (Thomson Reuters) Pathways for MAP3K2
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction JNK pathway
    Immune response Function of MEF2 in T lymphocytes

    5/7 BioSystems Pathways for MAP3K2 (see all 7)
        EGFR1 Signaling Pathway
    Insulin Signaling
    BDNF signaling pathway
    MAPK Cascade
    TNF-alpha/NF-kB Signaling Pathway

    1 Sino Biological Pathway for MAP3K2 
        Death Receptor Signaling


    3         Kegg Pathways  (Kegg details for MAP3K2):
        MAPK signaling pathway
    Gap junction
    GnRH signaling pathway


    MAP3K2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for MAP3K2 (Q9Y2U52, 3 ENSP000003434634) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STUB1Q9UNE72, 3, ENSP000002195484MINT-8010534 MINT-8012530 MINT-8010505 MINT-8010493 MINT-8010517 MINT-8010584 MINT-7996786 MINT-8010565 MINT-8010548 MINT-8010453 I2D: score=2 STRING: ENSP00000219548
    MAP3K5Q996832, 3, ENSP000003519084MINT-18083 MINT-18082 I2D: score=2 STRING: ENSP00000351908
    MAP3K3Q997592, 3MINT-48479 I2D: score=2 
    SFNP319472, 3MINT-3975452 I2D: score=2 
    UBCP0CG482, 3, ENSP000003448184MINT-8010627 I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS8621389
    GO:0006468protein phosphorylation TAS8621389
    GO:0007257activation of JUN kinase activity TAS8621389
    GO:0045893positive regulation of transcription, DNA-dependent IDA14515274
    GO:0071260cellular response to mechanical stimulus IEP19593445

    MAP3K2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP3K2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP3K2 (M3K2)

    3 HMDB Compounds for MAP3K2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    4 Novoseek inferred chemical compound relationships for MAP3K2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anisomycin 70.9 2 10347227 (1), 17699104 (1)
    lysine 6.27 1 11343802 (1)
    serine 3.61 5 11343802 (2), 16362041 (1)
    tyrosine 0 2 15242770 (1), 11032806 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP3K2 / M3K2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP3K2 gene: 
    NM_006609.4  

    Unigene Cluster for MAP3K2:

    Mitogen-activated protein kinase kinase kinase 2
    Hs.145605  [show with all ESTs]
    Unigene Representative Sequence: NM_006609
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409947(uc002toj.2) ENST00000344908 ENST00000409179
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/248 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K2 (see all 248):
    hsa-miR-640 hsa-miR-520f hsa-miR-199a-3p hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-759 hsa-miR-3921
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K2
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K2

    Additional mRNA sequence: 

    AB208963.1 AF111105.1 AF239798.1 AK027345.1 AK074577.1 AK075004.1 AK093893.1 AK315007.1 
    BC065755.1 BC136293.1 

    6 DOTS entries:

    DT.413941  DT.75171993  DT.209266  DT.100777384  DT.95235007  DT.91982939 

    24/274 AceView cDNA sequences (see all 274):

    AI288153 AA476361 AW664500 BE892693 AI627481 AW008728 AI474330 BM698966 
    BM069841 BM069595 CD673720 M62037 CB070122 AI587528 AA860134 CB306247 
    AA757873 AA828446 AW612171 AI493824 AK075004 AI813319 AI400127 AW850061 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K2 expression in normal human tissues (normalized intensities)      MAP3K2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCATTTTTT
    MAP3K2 Expression
    About this image


    MAP3K2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             brain/hindbrain   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Eye (Sensory Organs)
             retinal progenitor cell p0   
     
     Spinal Cord (Nervous System)

     -- (Nervous System)
             mouse/organ system/nervous system/central nervous system   

    See MAP3K2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K2

    SOURCE GeneReport for Unigene cluster: Hs.145605
        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP3K2: 
              EGF / PDGF Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP3K2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k21 , 5 mitogen-activated protein kinase kinase kinase 21, 5 91.98(n)1
    96.28(a)1
      18 (17.95 cM)5
    264051  NM_011946.31  NP_036076.21 
     321630895 
    chicken
    (Gallus gallus)
    Aves MAP3K21 mitogen-activated protein kinase kinase kinase 2 82.77(n)
    91.6(a)
      424225  XM_422075.3  XP_422075.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K26
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL343344.1(859293-884173)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153882 Xenopus laevis transcribed sequence with moderate similarity more 80.39(n)    BJ037579.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map3k21 mitogen-activated protein kinase kinase kinase 2 72.84(n)
    82.95(a)
      558321  XM_681521.1  XP_686613.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE116
    BCK16
    Signal transducing MEK kinase involved in pheromon...
    Mitogen-activated protein (MAP) kinase kinase kina...
    21(a)
    10(a)
    many ↔ many
    many ↔ many
    XII(849866-852019)
    X(247255-251691)


    ENSEMBL Gene Tree for MAP3K2 (if available)
    TreeFam Gene Tree for MAP3K2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP3K2 gene
    MAP3K12  MAP3K32  MAP3K52  MAP3K152  MAP3K82  MAP3K192  MAP3K62  
    18/41 SIMAP similar genes for MAP3K2 using alignment to 3 protein entries:     M3K2_HUMAN (see all proteins) (see all similar genes):
    MST094    MAP3K3    MAP3K1    MAP3K19    MAP3K15    MAP3K5
    STK11    YSK4    PAK1    PAK2    MAP3K4    MST4
    STK25    MAP3K6    STK4    STK24    MARK4    TAOK2

    MAP3K2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/940 SNPs in MAP3K2 are shown (see all 940)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406834
    A lung large cell carcinoma sample4--see VAR_0406832 M I mis40--------
    rs46625801,2
    C,F,H--127601977(+) acagaC/Actgca 1 -- us2k121Minor allele frequency- A:0.44NS EA NA WA CSA 2704
    rs75641891,2
    C,F,A--128055858(+) gaacgC/Tgggag 1 -- ds50012Minor allele frequency- T:0.50NA WA 4
    rs75900301,2
    C,F,A,H--128055967(+) CTCCAA/GCACCA 1 -- ds500125Minor allele frequency- G:0.20NS EA NA WA CSA 2485
    rs1844799301,2
    --128056020(+) GTTTGG/TGTTTG 1 -- ds50010--------
    rs1891835531,2
    --128056095(+) GTGGAA/GCATTA 1 -- ds50010--------
    rs1390101421,2
    C--128056111(+) TTAGAC/TACTGG 1 -- ds50010--------
    rs1818099981,2
    C--128056114(+) GATACC/TGGAAA 1 -- ds50010--------
    rs1163155241,2
    C,F--128056157(+) TCTGCG/ACTTGG 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1863640731,2
    C--128056164(+) TTGGTC/TTCCTA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MAP3K2 (128056245 - 128146041 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAP3K2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP3K2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609487    OMIM disorders: --

    15 diseases for MAP3K2:    About MalaCards
    cerebral cavernous malformations-2    cerebral cavernous malformation    protein s deficiency    cavernous malformation
    rheumatoid arthritis    arthritis    prostate cancer    neuroblastoma
    glioblastoma    hepatitis b    prostatitis    ovarian cancer
    cerebritis    hepatitis    endotheliitis


    MAP3K2 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for MAP3K2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 21.2 1 17559674 (1)
    necrosis 13 2 11097748 (1), 15242770 (1)
    prostate cancer 11.1 1 17695723 (1)
    osteoarthritis 1.9 1 14734742 (1)
    tumors 0 2 15242770 (1), 19690195 (1)

    Genetic Association Database (GAD): MAP3K2
    Human Genome Epidemiology (HuGE) Navigator: MAP3K2 (1 document)

    Export disorders for MAP3K2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K2 gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with MAP3K2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. (PubMed id 8621389)1, 3, 9 Blank J.L....Johnson G.L. (1996)
    2. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PubMed id 17906693)1, 2, 9 Enomoto A....Miyagawa K. (2008)
    3. XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2. (PubMed id 18761086)1, 2, 9 Winsauer G....de Martin R. (2008)
    4. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. (PubMed id 10713157)1, 2, 9 Cheng J.... Su B. (2000)
    5. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. (PubMed id 15075238)1, 2, 9 Raviv Z.... Seger R. (2004)
    6. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta. (PubMed id 10085062)1, 3, 9 Zhao Q. and Lee F.S. (1999)
    7. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    9. Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae. (PubMed id 16001074)1, 2 Pelkmans L. and Zerial M. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10746 HGNC: 6854 AceView: MAP3K2 Ensembl:ENSG00000169967 euGenes: HUgn10746
    ECgene: MAP3K2 Kegg: 10746 H-InvDB: MAP3K2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP3K2 gene:
    Search GeneIP for patents involving MAP3K2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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